Professor Istvan Toth

Chair in Biological Chemistry

School of Chemistry and Molecular Biosciences
Faculty of Science

Professor (Level E)

School of Pharmacy
Faculty of Health and Behavioural Sciences

Affil Professorial Research Fellow

Institute for Molecular Bioscience
i.toth@uq.edu.au
+61 7 334 69892

Overview

Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $60 million in competitive grants, research contracts and investment funds in the past 10 years.

Professor István Tóth is an Australian Research Council Australian Professorial Fellow; Chair in Biological Chemistry & Professor of Pharmacy at The University of Queensland (UQ), Brisbane, Australia; and Affiliated Professorial Research Fellow and Group Leader at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary (1969) and was awarded his PhD (1972) for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate (1977-82), then Scientific Group Leader (1982-87) at the Central Research Institute for Chemistry, Hungarian Academy of Science where he earned his Candidate of Science (C.Sc., 1979). He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctorate of Science (D.Sc., 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group (presently 30 members). Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013).

Professor Tóth has over 300 peer-reviewed publications, 43 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia (ASX listed), Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is also a Scientific Advisory Board Member of Implicit Bioscience Pty Ltd. Brisbane, Australia, and Proxima Concept Ltd, London, UK.

Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development. Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society. He is the Editor in Chief of Current Drug Delivery and Drug Delivery Letters, Associate Editor of Medicinal Chemistry; and the Board Member of Mini Reviews in Medicinal Chemistry, Open Drug Delivery, Open Medicinal Chemistry, and Current Patents in Drug Delivery.

Qualifications

  • Bachelor of Science, Bud
  • Doctor of Science, Bud
  • Diploma of Education (Science) (1969), Bud
  • Chem. Eng. Dipl. Medicinal Chemistry (1969), Bud
  • Doctor of Philosophy, Bud

Publications

View all Publications

Supervision

View all Supervision

Publications

Featured Publications

Book Chapter

  • Marasini, N., Ghaffar, K.A., Skwarczynski, M. and Toth, I. (2017). Liposomes as a vaccine delivery system. In Mariusz Skwarczynski and Istvan Toth (Ed.), Micro and Nanotechnology in Vaccine Development (pp. 221-239) Kidlington, Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-323-39981-4.00012-9

  • Eskandari, Sharareh, Stephenson, Rachel and Toth, Istvan (2016). Current boundaries in the formulation of lipid based delivery systems. In Abdus Samad, Sarwar Beg and Iram Nazish (Ed.), Liposomal delivery systems: advances and challenges (pp. 160-174) London, United Kingdom: Future Medicine. doi:10.4155/9781910419083

  • Ahmad Fuaad, Abdullah A. H., Skwarczynski, Mariusz and Toth, Istvan (2016). The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection. In Thomas, Sunil (Ed.), Vaccine design: methods and protocols: volume 1: vaccines for human diseases (pp. 639-653) New York, NY United States: Springer New York. doi:10.1007/978-1-4939-3387-7_36

  • Skwarczynskim, Mariusz, Zaman, Mehfuz and Toth, Istvan (2013). Lipo-peptides/saccharides in peptide vaccine delivery. In Abba J. Kastin (Ed.), Handbook of biologically active peptides 2nd ed. (pp. 571-579) Amsterdam, Netherlands: Academic Press/Elsevier. doi:10.1016/B978-0-12-385095-9.00078-6

  • Skwarczynski, Mariusz and Toth, Istvan (2011). Lipid core peptide system for self-adjuvanting synthetic vaccine delivery. In Sonny S. S. Mark (Ed.), Bioconjugation protocols: Strategies and methods 2nd ed. (pp. 297-308) New York , U.S.A: Humana Press. doi:10.1007/978-1-61779-151-2_18

  • Jackson, David C., Chua, Brendon Y., Brown, Lorena E., Moyle, Peter and Toth, Istvan (2010). Lipopeptide-based vaccines. In Myron M. Levine (Ed.), New generation vaccines 4th ed. (pp. 315-326) New York, U.S.A.; London, U.K.: Informa Healthcare.

  • Zaman, Mehfuz, Skwarczynski, Marius and Toth, Istvan (2010). Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design. In Lorraine C. Welles (Ed.), Dendritic Cells: Types, Life Cycles and Biological Functions (pp. 63-80) New York, NY, U.S.A.: Nova Science Publishers.

  • Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. In Bernkop-Schnurch, Andreas (Ed.), Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends 1st ed. (pp. 195-222) New York, United States: Springer. doi:10.1007/978-1-4419-0200-9_11

  • Blanchfield, J. T. and Toth, I. (2005). Modification of peptides and other drugs using lipoamino acids and sugars. In J. Howl (Ed.), Methods in Molecular Biology: Peptide Synthesis and Applications 1st ed. (pp. 45-61) New Jersey: Humana Press.

  • Wong, A., Bender, V. and Toth, I. (2003). Drug delivery systems utilizing lipids and sugars. In G. Keri and I. Toth (Ed.), Molecular Pathomechanisms and New Trends in Drug Research 1 ed. (pp. 599-612) London & New York: Taylor & Francis.

  • Keri, G. and Toth, I. (2003). Introduction: A breakthrough in modern drug research. In G. Keri and I. Toth (Ed.), Molecular Pathomechanisms and New Trends in Drug Research 1 ed. (pp. 1-4) London & New York: Taylor & Francis.

Journal Article

Conference Publication

Edited Outputs

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision