Professor Istvan Toth

Professor

School of Chemistry and Molecular Biosciences
Faculty of Science
i.toth@uq.edu.au
+61 7 334 69892

Overview

Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $60 million in competitive grants, research contracts and investment funds in the past 10 years.

Professor István Tóth is an Australian Research Council Australian Professorial Fellow; Chair in Biological Chemistry & Professor of Pharmacy at The University of Queensland (UQ), Brisbane, Australia; and Affiliated Professorial Research Fellow and Group Leader at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary (1969) and was awarded his PhD (1972) for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate (1977-82), then Scientific Group Leader (1982-87) at the Central Research Institute for Chemistry, Hungarian Academy of Science where he earned his Candidate of Science (C.Sc., 1979). He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctorate of Science (D.Sc., 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group (presently 30 members). Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013).

Professor Tóth has over 300 peer-reviewed publications, 43 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia (ASX listed), Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is also a Scientific Advisory Board Member of Implicit Bioscience Pty Ltd. Brisbane, Australia, and Proxima Concept Ltd, London, UK.

Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development. Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society. He is the Editor in Chief of Current Drug Delivery and Drug Delivery Letters, Associate Editor of Medicinal Chemistry; and the Board Member of Mini Reviews in Medicinal Chemistry, Open Drug Delivery, Open Medicinal Chemistry, and Current Patents in Drug Delivery.

Qualifications

  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Publications

View all Publications

Publications

Featured Publications

Book

  • Hussein, Waleed M., Stephenson, Rachel J. and Toth, Istvan eds. (2021). Peptide Conjugation : Methods and Protocols. Methods in Molecular Biology, New York, NY United States: Springer. doi: 10.1007/978-1-0716-1617-8

  • Waleed Hussein, Mariusz Skwarczynski and Istvan Toth eds. (2019). Peptide synthesis: methods and protocols. New York, NY USA: Humana New York. doi: 10.1007/978-1-0716-0227-0

  • Mariusz Skwarczynski and Istvan Toth eds. (2016). Micro- and nanotechnology in vaccine development. Amsterdam, Netherlands: Elsevier.

Book Chapter

  • Fan, Jingyi, Toth, Istvan and Stephenson, Rachel J. (2023). Bioconjugated materials in the development of subunit vaccines. Comprehensive analytical chemistry. (pp. *-*) Amsterdam, Netherlands: Elsevier. doi: 10.1016/bs.coac.2023.02.005

  • Koirala, Prashamsa, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Current Prospects in Peptide-Based Subunit Nanovaccines. Methods in Molecular Biology. (pp. 309-338) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_16

  • Firdaus, Farrhana Ziana, Skwarczynski, Mariusz and Toth, Istvan (2022). Developments in vaccine adjuvants. Vaccine Design: Methods and Protocols, Volume 3: Resources for Vaccine Development. (pp. 145-178) edited by Sunil Thomas. New York, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_8

  • Tóth, István György (2022). Kompország lakói 2022-ben : Az USA, az EU, Oroszország és Kína megítélése a magyar közvéleményben. Társadalmi Riport 2022. (pp. 431-453) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2022.22

  • Yang, Jieru, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2022). Liposomes for the delivery of lipopeptide vaccines. Methods in Molecular Biology. (pp. 295-307) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_15

  • Faruck, Mohammad Omer, Skwarczynski, Mariusz and Toth, Istvan (2022). Polymer–Peptide Conjugate Vaccine for Oral Immunization. Methods in Molecular Biology. (pp. 35-44) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_3

  • Zhao, Lili, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery. Methods in Molecular Biology. (pp. 141-149) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1900-1_9

  • Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates. Peptide conjugation: methods and protocols. (pp. 141-150) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_13

  • Madge, Harrison Y.R., Stephenson, Rachel J. and Toth, Istvan (2021). Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines. Handbook of nanotechnology applications: environment, energy, agriculture and medicine. (pp. 509-535) edited by Woei Jye Lau, Kajornsak Faungnawakij, Kuakoon Piyachomkwan and Uracha Rungsardthong Ruktanonchai. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821506-7.00020-x

  • Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition. Methods in Molecular Biology. (pp. 1-7) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_1

  • Hussein, Waleed M. and Toth, Istvan (2021). Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition. Peptide conjugation: methods and protocols. (pp. 57-64) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_6

  • Hussein, Waleed H., Stephenson, Rachel J. and Toth, Istvan (2021). Preface. Peptide conjugation: methods and protocols. (pp. v-v) New York, NY USA: Humana Press.

  • Tóth, István György and Hudácskó, Szilvia (2020). A koronavírus-járvány társadalmi hatásai a közvélemény-kutatások tükrében. Társadalmi Riport 2020. (pp. 553-572) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2020.25

  • Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides. Peptide synthesis: methods and protocols. (pp. 139-150) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer. doi: 10.1007/978-1-0716-0227-0_9

  • Medgyesi, Márton and Tóth, István György (2020). Kelet-Közép-Európa legújabb felzárkózási kísérlete: harminc évvel a rendszerváltások után. Társadalmi Riport 2020. (pp. 15-38) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2020.1

  • Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Preface. Peptide synthesis: methods and protocols. (pp. v-v) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer.

  • Tóth, István György and Szelényi, Iván (2019). The upper middle class: a new aristocracy? Posing the question for post-communist Hungary. Social Report. (pp. 101-119) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2019.6

  • Tóth, István György and Szelényi, Iván (2018). Bezáródás és fluiditás a magyar társadalom szerkezetében : Adatolt esszé a felső középosztály bezáródásáról. Társadalmi Riport. (pp. 25-46) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2018.2

  • Nevagi, Reshma J., Toth, Istvan and Skwarczynski, Mariusz (2018). Peptide-based vaccines. Peptide applications in biomedicine, biotechnology and bioengineering. (pp. 327-358) edited by Sotirios Koutsopoulos. Duxford, United Kingdom: Woodhead Publishing (Elsevier). doi: 10.1016/B978-0-08-100736-5.00012-0

  • Marasini, N., Ghaffar, K.A., Skwarczynski, M. and Toth, I. (2017). Liposomes as a vaccine delivery system. Micro and Nanotechnology in Vaccine Development. (pp. 221-239) edited by Mariusz Skwarczynski and Istvan Toth. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00012-9

  • Skwarczynski, Mariusz and Toth, Istvan (2017). Micro- and Nanotechnology in Vaccine Development - Introduction. Micro- and Nanotechnology in Vaccine Development . (pp. XVII-XVIII) edited by Skwarczynski, M. and Toth, I.. Kidlington, Oxford, United Kingdom: Elsevier Science.

  • Eskandari, Sharareh, Stephenson, Rachel and Toth, Istvan (2016). Current boundaries in the formulation of lipid based delivery systems. Liposomal delivery systems: advances and challenges. (pp. 160-174) edited by Abdus Samad, Sarwar Beg and Iram Nazish. London, United Kingdom: Future Medicine. doi: 10.4155/9781910419083

  • Skwarczynski, Mariusz and Toth, Istvan (2016). Introduction. Micro and nanotechnology in vaccine development: micro and nano technologies. (pp. xvii-xviii) edited by Mariusz Skwarczynski and Istvan Toth. Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00027-0

  • Tóth, István György (2016). Középosztály(ok) Magyarországon és Európában. Társadalmi Riport. (pp. 75-97) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2016.4

  • Ahmad Fuaad, Abdullah A. H., Skwarczynski, Mariusz and Toth, Istvan (2016). The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection. Vaccine design: methods and protocols: volume 1: vaccines for human diseases. (pp. 639-653) edited by Thomas, Sunil. New York, NY United States: Springer New York. doi: 10.1007/978-1-4939-3387-7_36

  • Skwarczynskim, Mariusz, Zaman, Mehfuz and Toth, Istvan (2013). Lipo-peptides/saccharides in peptide vaccine delivery. Handbook of biologically active peptides. (pp. 571-579) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00078-6

  • Skwarczynski, Mariusz and Toth, Istvan (2011). Lipid core peptide system for self-adjuvanting synthetic vaccine delivery. Bioconjugation protocols: Strategies and methods. (pp. 297-308) edited by Sonny S. S. Mark. New York , U.S.A: Humana Press. doi: 10.1007/978-1-61779-151-2_18

  • Jackson, David C., Chua, Brendon Y., Brown, Lorena E., Moyle, Peter and Toth, Istvan (2010). Lipopeptide-based vaccines. New generation vaccines. (pp. 315-326) edited by Myron M. Levine. New York, U.S.A.; London, U.K.: Informa Healthcare. doi: 10.3109/9781420060744-32

  • Zaman, Mehfuz, Skwarczynski, Marius and Toth, Istvan (2010). Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design. Dendritic Cells: Types, Life Cycles and Biological Functions. (pp. 63-80) edited by Lorraine C. Welles. New York, NY, U.S.A.: Nova Science Publishers.

  • Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. (pp. 195-222) edited by Bernkop-Schnurch, Andreas. New York, United States: Springer. doi: 10.1007/978-1-4419-0200-9_11

  • Blanchfield, J. T. and Toth, I. (2005). Modification of peptides and other drugs using lipoamino acids and sugars. Methods in Molecular Biology: Peptide Synthesis and Applications. (pp. 45-61) edited by John Howl. New Jersey: Humana Press. doi: 10.1385/1-59259-877-3:045

  • Wong, A., Bender, V. and Toth, I. (2003). Drug delivery systems utilizing lipids and sugars. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 599-612) edited by G. Keri and I. Toth. London & New York: Taylor & Francis. doi: 10.1201/9780203219973.ch45

  • Keri, G. and Toth, I. (2003). Introduction: A breakthrough in modern drug research. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 1-4) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.

  • Falconer, Robert A. and Toth, Istvan (2002). Lipoamino acid based glycoconjugates for peptide and drug delivery. Peptides for the New Millennium. (pp. 77-78) Dordrecht, The Netherlands: Kluwer Academic Publishers. doi: 10.1007/0-306-46881-6_310

  • Chan, Yiu-Ngok, Wong, Allan K. and Toth, Istvan (2001). Lipoamino Acid and Liposaccharide Conjugated Peptides: Enhancement of Bioavailability. Peptides: The Wave of the Future. (pp. 955-956) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-010-0464-0_445

  • Toth, Istvan, McGeary, Ross, Blanchfield, Joanne, Rhee, Handoo, Alewood, Paul, Adams, David and Good, Michael (2001). Liposaccharides: Utilisation for peptide delivery and for enhancing synthetic peptide immunogenicity. Peptides: The Wave of the Future. (pp. 937-939) edited by Michal Lebl and Richard A. Houghten. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-010-0464-0_437

  • Toth, Istvan, Danton, Malcolm, Reid, Ronald E., Zhong, Guangming, Brunham, Robert, Tóth, Gábor K. and Gibbons, William A. (1993). Lipidic amino acid based synthetic peptide vaccine adjuvant. Peptides 1992. (pp. 823-824) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-1470-7_377

  • del Olmo, Esther, Toth, Istvan, Fonteh, Alfred N. and Gibbons, William A. (1992). Synthesis and biological activity of heteroalkyl lipidic amino acids. Peptides. (pp. 452-453) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_171

  • Hussain, Rohanah, Toth, Istvan and Gibbons, William A. (1992). Synthesis of lipidic peptide conjugates of nucleoside antiviral and cytostatic agents. Peptides. (pp. 450-451) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_170

Journal Article

Conference Publication

Edited Outputs

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision