Professor Paul Young

Head of School

School of Chemistry and Molecular Biosciences
Faculty of Science

Affiliate Professor

Australian Institute for Bioengineering and Nanotechnology

Affiliated Professor

Institute for Molecular Bioscience
p.young@uq.edu.au
+61 7 336 54622
+61 7 336 54646

Overview

Molecular virology.

My group's research interests encompass the molecular biology and immunopathology of medically important viral infections including Ebola. Current studies are focussed on two different viruses; dengue virus, a serious mosquito-borne disease in many tropical countries, and Respiratory Syncytial Virus (RSV), a major cause of hospitalization of children with respiratory infections.

The primary goals of our research are the development of vaccine and anti-viral strategies for the control of infections as well as a clearer understanding of the pathogenesis of severe disease.

Current projects in my laboratory include:

  • Structural biology based studies on the dengue virus proteins, NS3 (the viral protease) and E (a virion surface protein involved in cell binding and entry) and the RSV protein F (the viral fusion protein) as targets for antiviral drug design
  • Sub-unit and DNA based vaccines for the dengue viruses
  • Molecular pathogenesis of severe dengue disease (in particular, the consequences of dengue virus infection of host macrophages and the induction of mediators of vascular leak)
  • Design and delivery of ribozymes (catalytic RNAs) to the respiratory tract as an antiviral strategy for RSV infections

These projects involve the application of a range of techniques covering a number of disciplines including molecular biology, immunology, biotechnology, molecular cell biology, protein biochemistry and structural biology.

Qualifications

  • PhD, University of London
  • Bachelor of Science (Honours), The University of Queensland

Publications

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Supervision

View all Supervision

Publications

Book Chapter

  • Depelsenaire, A. C. I., Kendall, M. A. F., Young, P. R. and Muller, D. A. (2017). Introduction to vaccines and vaccination. In Mariusz Skwarczynski and Istvan Toth (Ed.), Micro and nanotechnology in vaccine development (pp. 47-62) Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-323-39981-4.00003-8

  • Chappell, Keith J. and Young, Paul R. (2014). The nonstructural proteins of dengue virus. In D. J. Gubler, Eng Eong Ooi, Subhash Vasudevan and Jeremy Farrar (Ed.), Dengue and Dengue Hemorrhagic Fever: Second Edition 2nd ed. (pp. 377-405) Oxfordshire, United Kingdom: CABI International.

  • Muller, David and Young, Paul R. (2012). The many faces of the flavivirus non-structural glycoprotein NS1. In Pei-Yong Shi (Ed.), Molecular virology and control of flaviviruses (pp. 51-75) Norfolk, United Kingdom: Caister Academic Press.

  • Hans, Dhiraj, Young, Paul R. and Fairlie, David P. (2009). Tumor-associated antigenic peptides as vaccine candidates. In Olivier Gires and Barbara Seliger (Ed.), Tumor-associated antigens (pp. 303-316) Weinheim, Germany: Wiley - VCH Verlag.

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision