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The genetic basis of pathogen blocking: elucidating the contributions of the Wolbachia, dengue virus and mosquito genomes (2017–2022)

Abstract:
A bacterium called Wolbachia has been shown to stop dengue virus from replicating inside mosquitoes and so is being field-tested as a biocontrol agent against dengue fever. A major threat to this strategy is the emergence of resistance either in the mosquito or virus. This proposal addresses two fundamental knowledge gaps ¿ how does Wolbachia block virus growth and how might resistance evolve? This research is significant as it will inform the development of strategies to counter resistance.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Paul Young

    Professor, Research Development
    Office of the Deputy Vice-Chancellor (Research and Innovation)
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
National Health and Medical Research Council