Professor Bostjan Kobe

Professor

School of Chemistry and Molecular Biosciences
Faculty of Science

Affil Professorial Research Fellow

Institute for Molecular Bioscience
b.kobe@uq.edu.au
+61 7 336 52132

Overview

Dr Kobe's research interests are in protein structure and function, with the emphasis on understanding the structural basis of intra- and intermolecular interactions formed by these macromolecules.

The primary technique used in the laboratory is X-ray crystallography, combined with a plethora of other molecular biology, biophysical and computational techniques.

Current projects include:

  • Structural genomics of macrophage proteins
  • Understanding the mechanism and specificity of nuclear import
  • Structural basis of signal transduction
  • Structural basis of plant disease resistance and development
  • Molecular and structural basis of retroviral and dengue virus membrane fusion

Qualifications

  • Doctor of Philosophy, University of Texas
  • Diploma Engineer of Chemistry, UL

Publications

  • Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017) Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 32: E6480-E6489. doi:10.1073/pnas.1701868114

  • Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017) Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 743-751. doi:10.1038/nsmb.3444

  • Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017) Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, . doi:10.1016/j.tplants.2017.06.013

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Ellis, Jonathan J. and Kobe, Boštjan (2013). Protein phosphorylation. In Gordon C. K. Roberts (Ed.), Encyclopedia of biophysics (pp. 2037-2040) Berlin, Germany: Springer-Verlag. doi:10.1007/978-3-642-16712-6_184

  • Mouradov, Dmitri, Kobe, Bostjan, Dixon, Nicholas E. and Huber, Thomas (2010). Hybrid methods for protein structure prediction. In Huzefa Rangwala and George Karypis (Ed.), Introduction to protein structure prediction: Methods and algorithms (pp. 265-277) Hoboken, New Jersey, USA: John Wiley and Sons, Inc..

  • Li, Sheng, Mouradov, Dmitri, King, Gordon, Liu, Tong, Ross, Ian, Kobe, Bostjan, Woods, Virgil L. and Huber, Thomas (2009). Study of protein three-dimensional structure and dynamics determination using peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling. In Gu, Jenny and Bourne, Phillip E. (Ed.), Structural Bioinformatics 2nd ed. (pp. 171-206) Hoboken, N.J.: Wiley-Blackwell.

  • Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. In Kobe, B., Guss, M. and Huber, T.L. (Ed.), Structural Proteomics: High-Throughput Methods 1st ed. (pp. 27-35) Totowa, NJ, USA: Humana Press.

  • Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. In Bostjan Kobe, Mitchell Guss and Thomas Huber (Ed.), Structural Proteomics: High throughput Methods (pp. 269-275) USA: Humana Press.

  • Thakur, A. S., Newman, J., Martin, J. L. and Kobe, B. (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. In B. Kobe, M. Guss and T. Huber (Ed.), Structural Proteomics: High-throughput Methods (pp. 403-409) USA: Humana Press.

  • Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. In B. Kobe, M. Guss and T. L. Huber (Ed.), Structural proteomics: High-throughput methods (pp. 577-587) Totowa, N.J.: Humana Press.

  • Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. In Bostjan Kobe, Mitchell Guss and Thomas L. Huber (Ed.), Structural Proteomics: High Throughput Methods 1 ed. (pp. 459-474) Totowa, NJ, USA: Humana Press.

  • Brinkworth, R. I., Kobe, B. and Kemp, B.L.E. (2004). Peptide substrates of cyclic nucleotide-dependent protein kinases. In R. A. Bradshaw and E. A. Dennis (Ed.), Handbook of Cell Signaling 1st ed. (pp. 495-499) USA: Academic Press.

  • Kobe, B. and Kemp, B. E. (2004). Principles of kinase regulation. In R. A. Bradshaw and E. A. Dennis (Ed.), Handbook of Cell Signaling Vol 1 1st ed. (pp. 539-542) USA: Academic Press.

  • Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2002). Conserved sequence motifs in protein kinase families. In M Michael Gromiha and S Selvaraj (Ed.), Recent Research Developments in Protein Folding Stability and Design 1st ed. (pp. 67-77) Trivandrum, India: Research Signpost.

  • Heierhorst, Jorg, Pearson, Richard, Horne, James, Bozinovski, Steven, Kobe, Bostjan and Kemp, Bruce E. (2000). Protein serine/threonine kinases. In Michael Conn P. and Anthony R. Means (Ed.), Principles of Molecular Regulation 1st ed. (pp. 297-310) Totowa, N.J., USA: Humana Press.

  • Kobe, Bostjan, Gleichmann, Thomas, Teh, Trazel, Heierhorst, Jorg and Kemp, Bruce E. (1999). Crystallization of protein kinases and phosphatases. In D. Grahame Hardie (Ed.), Protein phosphorylation: A practical approach 2nd ed. (pp. 387-422) Oxford, UK: Oxford University Press.

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision