The University of Queensland

The network collective: Rise and fall of a scientific paradigm

Eichmann, Klaus, Avery, Oswald T., Baltimore, David, Von Behring, Emil, Benacerraf, Baruj, Bloor, David, Bordet, Jules J.B.V., Bona, Constantin A., Boyse, Edward A., Burnet, F. Macfarlane, Cantor, Harvey, Cazenave, Pierre A., Claman, Henry N., Cohn, Melvin, Coutinho, Antonio, Davis, Mark M., Crick, Francis H., Dobzhansky, Theodosius G., Doherty, Peter C., Eco, Umberto, Edelman, Gerald M., Ehrlich, Paul, Feyerabend, Paul, Fleck, Ludwik, Fujimura, Joan, Gershon, Richard K., Germain, Ronald N., Gowans, James L., Greene, Mark I. ... Zinkernagel, Rolf M. (2008). The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG. doi: 10.1007/978-3-7643-8373-2

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6

Transcriptional regulation and macrophage differentiation

Hume, David A., Summers, Kim M. and Rehli, Michael (2017). Transcriptional regulation and macrophage differentiation. Myeloid cells in health and disease: a synthesis. (pp. 119-139) edited by Siamon Gordon. Washington, DC United States: ASM Press. doi: 10.1128/9781555819194.ch8

The impact of CAGE data on understanding macrophage transcriptional biology

Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription. (pp. 227-243) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814241359

The impact of CAGE data on the understanding of macrophage transcriptional biology

Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription. (pp. 227-244) edited by Piero Carninci. Singapore: Pan Stanford Publishing.

A general target selection method for crystallographic proteomics

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2

A medium or high throughput protein refolding assay

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17

Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38

Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31

Transcriptional Regulatory Networks in Macrophages

Hume, David A., Wells, Christine A. and Ravasi, Timothy (2007). Transcriptional Regulatory Networks in Macrophages. Decoding the Genomic Control of Immune Reactions. (pp. 2-24) Chichester, UK: wiley. doi: 10.1002/9780470062128.ch2

Noncoding RNA's in mammals

Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics. (pp. xx-xx) edited by Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam. USA: John Wiley & Sons, Inc.. doi: 10.1002/047001153X.g203204

The Biology of Macrophages

Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. The Innate Immune Response to Infection. (pp. 71-94) edited by Kaufmann, SE.; Medzhitov, R.; Gordon and S.. Washington, DC, USA: ASM Press.

Phosphorothioate backbone modification changes the pattern of responses to CpG

Stacey, K. J., Sester, D. P., Naik, S., Roberts, T., Sweet, M. J. and Hume, D. A. (2002). Phosphorothioate backbone modification changes the pattern of responses to CpG. Microbial DNA and host immunity. (pp. 63-77) Totowa, New Jersey: Humana Press. doi: 10.1007/978-1-59259-305-7_6

Growth and differentiation of murine macrophages

Hume, D. A., Stacey, K. J., Cassady, A. ., Browne, C. M., Sweet, M. J. and Bertoncello, I. (1996). Growth and differentiation of murine macrophages. Handbook of experimental immunology. (pp. 160.1-160.10) Boston: Wiley-Blackwell.

The regulation of urokinase plasminogen activator gene expression in macrophages

Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. Mononuclear Phagocytes: Biology of Monocytes and Macrophages. (pp. 233-240) edited by van Furth, R.. Dordrecht , Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8070-0

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Macrophage heterogeneity in the single cell era: facts and artefacts

Hume, David A, Millard, Susan M and Pettit, Allison R. (2023). Macrophage heterogeneity in the single cell era: facts and artefacts. Blood Journal, 142 (16), 1339-1347. doi: 10.1182/blood.2023020597

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312. doi: 10.1002/eji.202250312

Rare genetic variants underlie outlying levels of DNA methylation and gene-expression

Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028

Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?

Hume, David A. (2023). Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?. European Journal of Immunology, 53 (6) 2250242. doi: 10.1002/eji.202250242

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Grootveld, Abigail K., Kyaw, Wunna, Panova, Veera, Lau, Angelica W.Y., Ashwin, Emily, Seuzaret, Guillaume, Dhenni, Rama, Bhattacharyya, Nayan Deger, Khoo, Weng Hua, Biro, Maté, Mitra, Tanmay, Meyer-Hermann, Michael, Bertolino, Patrick, Tanaka, Masato, Hume, David A., Croucher, Peter I., Brink, Robert, Nguyen, Akira, Bannard, Oliver and Phan, Tri Giang (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell, 186 (6), 1144-1161. doi: 10.1016/j.cell.2023.02.004

Fibrillin-1 and asprosin, novel players in metabolic syndrome

Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784

Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y

Microglia states and nomenclature: A field at its crossroads

Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam ... Wyss-Coray, Tony (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi: 10.1016/j.neuron.2022.10.020

CSF1R as a therapeutic target in bone diseases: obvious but not so simple

Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4

Poincaré profiles of Lie groups and a coarse geometric dichotomy

Hume, David, Mackay, John M. and Tessera, Romain (2022). Poincaré profiles of Lie groups and a coarse geometric dichotomy. Geometric and Functional Analysis, 32 (5), 1063-1133. doi: 10.1007/s00039-022-00617-4

Graphia: a platform for the graph-based visualisation and analysis of high dimensional data

Freeman, Tom C., Horsewell, Sebastian, Patir, Anirudh, Harling-Lee, Josh, Regan, Tim, Shih, Barbara B., Prendergast, James, Hume, David A. and Angus, Tim (2022). Graphia: a platform for the graph-based visualisation and analysis of high dimensional data. PLOS Computational Biology, 18 (7) e1010310, 1-17. doi: 10.1371/journal.pcbi.1010310

Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells

Hume, David A., Offermanns, Stefan and Bonnavion, Remy (2022). Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55 (7), 1139-1140. doi: 10.1016/j.immuni.2022.06.010

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek and Blurton-Jones, Mathew (2022). Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Reports, 39 (11) 110961, 1-30. doi: 10.1016/j.celrep.2022.110961

Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer

Laviron, Marie, Petit, Maxime, Weber-Delacroix, Eléonore, Combes, Alexis J., Arkal, Arjun Rao, Barthélémy, Sandrine, Courau, Tristan, Hume, David A., Combadière, Christophe, Krummel, Matthew F. and Boissonnas, Alexandre (2022). Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. Cell Reports, 39 (8) 110865, 1-20. doi: 10.1016/j.celrep.2022.110865

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237

Generation and network analysis of an RNA-seq transcriptional atlas for the rat

Summers, Kim M., Bush, Stephen J., Wu, Chunlei and Hume, David A. (2022). Generation and network analysis of an RNA-seq transcriptional atlas for the rat. NAR Genomics and Bioinformatics, 4 (1) lqac017, lqac017. doi: 10.1093/nargab/lqac017

1015 – APPEARANCES CAN BE DECEIVING: MACROPHAGE FRAGMENTATION CONFOUNDS EX VIVO HAEMATOPOIETIC TISSUE ANALYSIS

Pettit, Allison R, Batoon, Lena, Heng, Ostyn, Hume, David, Irvine, Kate, Kaur, Simranpreet, Levesque, Jean-Pierre, Magor, Graham, Millard, Susan, Noll, Jacqueline, Perkins, Andrew, Raggatt, Liza, Sandrock, Cheyenne, Sehgal, Anuj, Sester, David, Opperman, Khatora Shanae, Summers, Kim, Wu, Andy and Zannettino, Andrew (2022). 1015 – APPEARANCES CAN BE DECEIVING: MACROPHAGE FRAGMENTATION CONFOUNDS EX VIVO HAEMATOPOIETIC TISSUE ANALYSIS. Experimental Hematology, 111, S23. doi: 10.1016/j.exphem.2022.07.018

Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells

Hume, David A. (2022). Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells. Hepatology, 78 (2), n/a-n/a. doi: 10.1002/hep.32809

Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain

Bradford, Barry M., McGuire, Lynne I., Hume, David A., Pridans, Clare and Mabbott, Neil A. (2022). Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain. GLIA, 70 (11), 2169-2187. doi: 10.1002/glia.24244

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection

Lisowski, Zofia M., Lefevre, Lucas, Mair, Tim S., Clark, Emily L., Hudson, Neil P. H., Hume, David A. and Pirie, R. Scott (2022). Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection. Equine Veterinary Journal, 54 (1), 52-62. doi: 10.1111/evj.13429

A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature Communications, 12 (1) 3297. doi: 10.1038/s41467-021-23143-7

Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter

Psifidi, Androniki, Kranis, Andreas, Rothwell, Lisa M., Bremner, Abi, Russell, Kay, Robledo, Diego, Bush, Stephen J., Fife, Mark, Hocking, Paul M., Banos, Georgios, Hume, David A., Kaufman, Jim, Bailey, Richard A., Avendano, Santiago, Watson, Kellie A., Kaiser, Pete and Stevens, Mark. P. (2021). Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter. Scientific Reports, 11 (1) 1623. doi: 10.1038/s41598-020-79005-7

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058

Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells

Wu, Zhiguang, Hu, Tuanjun, Chintoan-Uta, Cosmin, Macdonald, Joni, Stevens, Mark P., Sang, Helen, Hume, David A., Kaiser, Pete and Balic, Adam (2021). Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells. Immunology, 165 (2), 171-194. doi: 10.1111/imm.13426

Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair

Sehgal, Anuj, Irvine, Katharine M. and Hume, David A. (2021). Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Seminars in Immunology, 54 101509, 101509. doi: 10.1016/j.smim.2021.101509

Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones

Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605

Actions of small cancellation groups on hyperbolic spaces

Abbott, Carolyn R. and Hume, David (2021). Actions of small cancellation groups on hyperbolic spaces. Geometriae Dedicata, 212 (1), 325-363. doi: 10.1007/s10711-020-00561-3

CRISPR-Cas9 editing of human histone deubiquitinase gene USP16 in human monocytic leukemia cell line THP-1

Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Rojo, Rocio, Hume, David A., Lengeling, Andreas and Summers, Kim M. (2021). CRISPR-Cas9 editing of human histone deubiquitinase gene USP16 in human monocytic leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 9 679544. doi: 10.3389/fcell.2021.679544

The mononuclear phagocyte system of the rat

Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268

The equine mononuclear phagocyte system: the relevance of the horse as a model for understanding human innate immunity

Karagianni, Anna E., Lisowski, Zofia M., Hume, David A. and Scott Pirie, R. (2021). The equine mononuclear phagocyte system: the relevance of the horse as a model for understanding human innate immunity. Equine Veterinary Journal, 53 (2), 231-249. doi: 10.1111/evj.13341

Whole-genome sequence data suggest environmental adaptation of Ethiopian sheep populations

Wiener, Pamela, Robert, Christelle, Ahbara, Abulgasim, Salavati, Mazdak, Abebe, Ayele, Kebede, Adebabay, Wragg, David, Friedrich, Juliane, Vasoya, Deepali, Hume, David A., Djikeng, Appolinaire, Watson, Mick, Prendergast, James G D, Hanotte, Olivier, Mwacharo, Joram M. and Clark, Emily L. (2021). Whole-genome sequence data suggest environmental adaptation of Ethiopian sheep populations. Genome Biology and Evolution, 13 (3) evab014, 1-18. doi: 10.1093/gbe/evab014

Transcriptomic analysis of rat macrophages

Pridans, Clare, Irvine, Katharine M, Davis, Gemma M, Lefevre, Lucas, Bush, Stephen J and Hume, David A (2021). Transcriptomic analysis of rat macrophages. Frontiers in Immunology, 11 594594. doi: 10.3389/fimmu.2020.594594

On the utility of CSF1R inhibitors

Green, Kim N. and Hume, David A. (2021). On the utility of CSF1R inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 118 (4) e2019695118, 1-2. doi: 10.1073/pnas.2019695118

Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice

Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w

CNS macrophages differentially rely on an intronic Csf1r enhancer for their development

Munro, David A.D., Bradford, Barry M., Mariani, Samanta A., Hampton, David W., Vink, Chris S., Chandran, Siddharthan, Hume, David A., Pridans, Clare and Priller, Josef (2020). CNS macrophages differentially rely on an intronic Csf1r enhancer for their development. Development, 147 (23) dev194449, 1-9. doi: 10.1242/dev.194449

A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system

Grabert, Kathleen, Sehgal, Anuj, Irvine, Katharine M., Wollscheid-Lengeling, Evi, Ozdemir, Derya D., Stables, Jennifer, Luke, Garry A., Ryan, Martin D., Adamson, Antony, Humphreys, Neil E., Sandrock, Cheyenne J., Rojo, Rocio, Verkasalo, Veera A., Mueller, Werner, Hohenstein, Peter, Pettit, Allison R., Pridans, Clare and Hume, David A. (2020). A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system. Journal of Immunology, 205 (11), 3154-3166. doi: 10.4049/jimmunol.2000835

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Dutta, Prasun, Talenti, Andrea, Young, Rachel, Jayaraman, Siddharth, Callaby, Rebecca, Jadhav, Santosh Kumar, Dhanikachalam, Velu, Manikandan, Mayakannan, Biswa, Bhim B., Low, Wai Y., Williams, John L., Cook, Elizabeth, Toye, Phil, Wall, Eileen, Djikeng, Appolinaire, Marshall, Karen, Archibald, Alan L., Gokhale, Suresh, Kumar, Satish, Hume, David A. and Prendergast, James G. D. (2020). Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication. Nature Communications, 11 (1) 4739. doi: 10.1038/s41467-020-18550-1

Poorly connected groups

Hume, David and Mackay, John M. (2020). Poorly connected groups. Proceedings of the American Mathematical Society, 148 (11), 4653-4664. doi: 10.1090/proc/15128

Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system

Summers, Kim M., Bush, Stephen J. and Hume, David A. (2020). Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system. PLoS Biology, 18 (10) e3000859, 1-45. doi: 10.1371/journal.pbio.3000859

Measurement of serum Interleukin 34 (IL-34) and correlation with severity and pruritus scores in client-owned dogs with atopic dermatitis

Gow, Deborah J., Jackson, Hilary, Forsythe, Peter, Nuttall, Tim, Gow, Adam G., Mellanby, Richard J. and Hume, David A. (2020). Measurement of serum Interleukin 34 (IL-34) and correlation with severity and pruritus scores in client-owned dogs with atopic dermatitis. Veterinary Dermatology, 31 (5), 359-e94. doi: 10.1111/vde.12873

Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries)

Tsang, Hiu-Gwen, Clark, Emily L., Markby, Greg R., Bush, Stephen J., Hume, David A., Corcoran, Brendan M., MacRae, Vicky E. and Summers, Kim M. (2020). Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries). Frontiers in Genetics, 11 919. doi: 10.3389/fgene.2020.00919

Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract

Lisowski, Zofia M., Sauter, Kristin A., Waddell, Lindsey A., Hume, David A., Pirie, R. Scott and Hudson, Neil P.H. (2020). Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract. Veterinary Immunology and Immunopathology, 226 110073, 110073. doi: 10.1016/j.vetimm.2020.110073

Species-specificity of transcriptional regulation and the response to lipopolysaccharide in mammalian macrophages

Bush, Stephen J., McCulloch, Mary E. B., Lisowski, Zofia M., Muriuki, Charity, Clark, Emily L., Young, Rachel, Pridans, Clare, Prendergast, James G. D., Summers, Kim M. and Hume, David A. (2020). Species-specificity of transcriptional regulation and the response to lipopolysaccharide in mammalian macrophages. Frontiers in Cell and Developmental Biology, 8 661. doi: 10.3389/fcell.2020.00661

The transcriptional network that controls growth arrest and macrophage differentiation in the human myeloid leukemia cell line THP-1

Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Clohisey, Sara, Arner, Erik, de Hoon, Michiel, Severin, Jessica, van Duin, Lucas, Andersson, Robin, Lengeling, Andreas, Hume, David A. and Summers, Kim M. (2020). The transcriptional network that controls growth arrest and macrophage differentiation in the human myeloid leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 8 498. doi: 10.3389/fcell.2020.00498

An improved pig reference genome sequence to enable pig genetics and genomics research

Warr, Amanda, Affara, Nabeel, Aken, Bronwen, Beiki, Hamid, Bickhart, Derek M., Billis, Konstantinos, Chow, William, Eory, Lel, Finlayson, Heather A., Flicek, Paul, Girón, Carlos G., Griffin, Darren K., Hall, Richard, Hannum, Greg, Hourlier, Thibaut, Howe, Kerstin, Hume, David A., Izuogu, Osagie, Kim, Kristi, Koren, Sergey, Liu, Haibou, Manchanda, Nancy, Martin, Fergal J., Nonneman, Dan J., O'Connor, Rebecca E., Phillippy, Adam M., Rohrer, Gary A., Rosen, Benjamin D., Rund, Laurie A. ... Archibald, Alan L. (2020). An improved pig reference genome sequence to enable pig genetics and genomics research. GigaScience, 9 (6) GIAA051. doi: 10.1093/gigascience/giaa051

Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders

Wittenberg, Gayle M., Stylianou, Annie, Zhang, Yun, Sun, Yu, Gupta, Ashutosh, Jagannatha, P. S., Wang, Dai, Hsu, Benjamin, Curran, Mark E., Khan, Shahid, Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Carvalho, Livia, Bell, Joshua, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil ... MRC ImmunoPsychiatry Consortium (2020). Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders. Molecular Psychiatry, 25 (6), 1275-1285. doi: 10.1038/s41380-019-0471-8

Comprehensive characterization of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences

Clohisey, Sara, Parkinson, Nicholas, Wang, Bo, Bertin, Nicolas, Wise, Helen, Tomoiu, Andru, Summers, Kim M., Hendry, Ross W., Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Digard, Paul, Hume, David A. and Baillie, J. Kenneth (2020). Comprehensive characterization of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences. Journal of Virology, 94 (10) e01720-19. doi: 10.1128/JVI.01720-19

Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system

Wu, Zhiguang, Harne, Rakhi, Chintoan-Uta, Cosmin, Hu, Tuan-Jun, Wallace, Robert, MacCallum, Amanda, Stevens, Mark P., Kaiser, Pete, Balic, Adam and Hume, David A. (2020). Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system. Developmental and Comparative Immunology, 105 103586, 103586. doi: 10.1016/j.dci.2019.103586

Poincaré profiles of groups and spaces

Hume, David, Mackay, John M. and Tessera, Romain (2020). Poincaré profiles of groups and spaces. Revista Matematica Iberoamericana, 36 (6), 1835-1886. doi: 10.4171/RMI/1184

Functional annotation of the transcriptome of the pig, Sus scrofa, based upon network analysis of an RNAseq transcriptional atlas

Summers, Kim M., Bush, Stephen J., Wu, Chunlei, Su, Andrew I., Muriuki, Charity, Clark, Emily L., Finlayson, Heather A., Eory, Lel, Waddell, Lindsey A., Talbot, Richard, Archibald, Alan L. and Hume, David A. (2020). Functional annotation of the transcriptome of the pig, Sus scrofa, based upon network analysis of an RNAseq transcriptional atlas. Frontiers in Genetics, 10 1355. doi: 10.3389/fgene.2019.01355

Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation

Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C. A., Beveridge, A. J., Brown, H., Hume, D. A., Harris, S. E., Deary, I. J., Tenesa, A. and Prendergast, J. G.D. (2020). Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. Nature Communications, 11 (1) 343. doi: 10.1038/s41467-019-13762-6

The geometry of generalized loxodromic elements

Abbott, Carolyn R. and Hume, David (2020). The geometry of generalized loxodromic elements. Annales de l'Institut Fourier, 70 (4), 1689-1713. doi: 10.5802/AIF.3379

Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep

Banos, Georgios, Clark, Emily L., Bush, Stephen J., Dutta, Prasun, Georgios Bramis, D., Arsenos, Georgios, Hume, David A. and Psifidi, Androniki (2019). Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep. PLoS One, 14 (11) e0214346, e0214346. doi: 10.1371/journal.pone.0214346

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

Halachev, Mihail, Meynert, Alison, Taylor, Martin S., Vitart, Veronique, Kerr, Shona M., Klaric, Lucija, Consortium, S. G.P., Aitman, Timothy J., Haley, Chris S., Prendergast, James G., Pugh, Carys, Hume, David A., Harris, Sarah E., Liewald, David C., Deary, Ian J., Semple, Colin A. and Wilson, James F. (2019). Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. PLoS Genetics, 15 (11) e1008480, e1008480. doi: 10.1371/journal.pgen.1008480

Analysis of the progeny of sibling matings reveals regulatory variation impacting the transcriptome of immune cells in commercial chickens

Freem, Lucy, Summers, Kim M., Gheyas, Almas A., Psifidi, Androniki, Boulton, Kay, MacCallum, Amanda, Harne, Rakhi, O’Dell, Jenny, Bush, Stephen J. and Hume, David A. (2019). Analysis of the progeny of sibling matings reveals regulatory variation impacting the transcriptome of immune cells in commercial chickens. Frontiers in Genetics, 10 1032. doi: 10.3389/fgene.2019.01032

A mini-atlas of gene expression for the domestic goat (Capra hircus)

Muriuki, Charity, Bush, Stephen J., Salavati, Mazdak, McCulloch, Mary E.B., Lisowski, Zofia M., Agaba, Morris, Djikeng, Appolinaire, Hume, David A. and Clark, Emily L. (2019). A mini-atlas of gene expression for the domestic goat (Capra hircus). Frontiers in Genetics, 10 1080, 1080. doi: 10.3389/fgene.2019.01080

Developmental stage-specific distribution of macrophages in mouse mammary gland

Stewart, Teneale A., Hughes, Katherine, Hume, David A. and Davis, Felicity M. (2019). Developmental stage-specific distribution of macrophages in mouse mammary gland. Frontiers in Cell and Developmental Biology, 7 250, 250. doi: 10.3389/fcell.2019.00250

Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian m cells in the avian follicle-associated epithelium

Balic, Adam, Chintoan-Uta, Cosmin, Vohra, Prerna, Sutton, Kate M., Cassady-Cain, Robin L., Hu, Tuan, Donaldson, David S., Stevens, Mark P., Mabbott, Neil A., Hume, David A., Sang, Helen M. and Vervelde, Lonneke (2019). Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian m cells in the avian follicle-associated epithelium. Frontiers in Immunology, 10 (OCT) 2495, 2495. doi: 10.3389/fimmu.2019.02495

Elimination of reference mapping bias reveals robust immune related allele-specific expression in crossbred sheep

Salavati, Mazdak, Bush, Stephen J., Palma-Vera, Sergio, McCulloch, Mary E. B., Hume, David A. and Clark, Emily L. (2019). Elimination of reference mapping bias reveals robust immune related allele-specific expression in crossbred sheep. Frontiers in Genetics, 10 863, 863. doi: 10.3389/fgene.2019.00863

Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds

Hume, David A., Gutowska‐Ding, Maria W., Garcia‐Morales, Carla, Kebede, Adebabay, Bamidele, Oladeji, Trujillo, Adriana Vallejo, Gheyas, Almas A. and Smith, Jacqueline (2019). Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds. Journal of Leukocyte Biology, 107 (2) JLB.6MA0519-172R, 237-250. doi: 10.1002/jlb.6ma0519-172r

Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene

Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r

Assembly of a parts list of the human mitotic cell cycle machinery

Giotti, Bruno, Chen, Sz-Hau, Barnett, Mark W., Regan, Tim, Ly, Tony, Wiemann, Stefan, Hume, David A. and Freeman, Tom C. (2019). Assembly of a parts list of the human mitotic cell cycle machinery. Journal of Molecular Cell Biology, 11 (8), 703-718. doi: 10.1093/jmcb/mjy063

Phenotypic impacts of CSF1R deficiencies in humans and model organisms

Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019). Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, 107 (2) JLB.MR0519-143R, 205-219. doi: 10.1002/jlb.mr0519-143r

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

Rojo, Rocío, Raper, Anna, Ozdemir, Derya D., Lefevre, Lucas, Grabert, Kathleen, Wollscheid-Lengeling, Evi, Bradford, Barry, Caruso, Melanie, Gazova, Iveta, Sánchez, Alejandra, Lisowski, Zofia M., Alves, Joana, Molina-Gonzalez, Irene, Davtyan, Hayk, Lodge, Rebecca J., Glover, James D., Wallace, Robert, Munro, David A. D., David, Eyal, Amit, Ido, Miron, Véronique E., Priller, Josef, Jenkins, Stephen J., Hardingham, Giles E., Blurton-Jones, Mathew, Mabbott, Neil A., Summers, Kim M., Hohenstein, Peter, Hume, David A. and Pridans, Clare (2019). Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications, 10 (1) 3215, 3215. doi: 10.1038/s41467-019-11053-8

Erratum: Pleiotropic impacts of macrophage ands microglial deficiency on development in rats with targeted mutation of the Csf1r locus (Journal of Immunology (2019) 201 (2683-2699) DOI: 10.4049/jimmunol.1701783)

Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J., Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2019). Erratum: Pleiotropic impacts of macrophage ands microglial deficiency on development in rats with targeted mutation of the Csf1r locus (Journal of Immunology (2019) 201 (2683-2699) DOI: 10.4049/jimmunol.1701783). Journal of Immunology, 202 (11), 3334-3335. doi: 10.4049/jimmunol.1900420

Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait

Chundru, V. Kartik, Marioni, Riccardo E., Prendergast, James G. D., Vallerga, Costanza L., Lin, Tian, Berveridge, Allan J., SGPD Consortium, Gratten, Jacob, Hume, David A., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2019). Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait. Genetics, 212 (3), 577-586. doi: 10.1534/genetics.118.301861

Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis

Gow, Debbie J., Jackson, Hilary, Forsythe, Peter, Gow, Adam G., Mellanby, Richard J., Hume, David A. and Nuttall, Tim (2019). Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis. Veterinary Dermatology, 30 (2), 115-e32. doi: 10.1111/vde.12721

The effect of race training on the basal gene expression of alveolar macrophages derived from Standardbred racehorses

Karagianni, Anna E., Summers, Kim M., Couroucé, Anne, Depecker, Marianne, McGorum, Bruce C., Hume, David A. and Pirie, R. Scott (2019). The effect of race training on the basal gene expression of alveolar macrophages derived from Standardbred racehorses. Journal of Equine Veterinary Science, 75, 48-54. doi: 10.1016/j.jevs.2019.01.010

Correction to: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Nature Immunology, (2018), 19, 6, (625-635), 10.1038/s41590-018-0111-5)

Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2019). Correction to: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Nature Immunology, (2018), 19, 6, (625-635), 10.1038/s41590-018-0111-5). Nature Immunology, 20 (3), 373-373. doi: 10.1038/s41590-019-0328-y

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

Prendergast, James G D, Pugh, Carys, Harris, Sarah E., Hume, David A., Deary, Ian J. and Beveridge, Allan (2019). Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution. Genome Biology and Evolution, 11 (3), 759-775. doi: 10.1093/gbe/evz014

Relatively hyperbolic groups with fixed peripherals

Cordes, Matthew and Hume, David (2019). Relatively hyperbolic groups with fixed peripherals. Israel Journal of Mathematics, 230 (1), 443-470. doi: 10.1007/s11856-019-1830-5

Causes and consequences of innate immune dysfunction in cirrhosis

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 (FEB) 293, 293. doi: 10.3389/fimmu.2019.00293

Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R

Hu, Tuanjun, Wu, Zhiguang, Bush, Stephen J., Freem, Lucy, Vervelde, Lonneke, Summers, Kim M., Hume, David A., Balic, Adam and Kaiser, Pete (2019). Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R. The Journal of Immunology, 202 (4), 1186-1199. doi: 10.4049/jimmunol.1800504

Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression

Bush, Stephen J., McCulloch, Mary E. B., Muriuki, Charity, Salavati, Mazdak, Davis, Gemma M., Farquhar, Iseabail L., Lisowski, Zofia M., Archibald, Alan L., Hume, David A. and Clark, Emily L. (2019). Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression. G3: Genes, Genomes, Genetics, 9 (2), 359-373. doi: 10.1534/g3.118.200810

The mononuclear phagocyte system: the relationship between monocytes and macrophages

Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019). The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 (2), 98-112. doi: 10.1016/j.it.2018.11.007

Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity

Low, Wai Yee, Tearle, Rick, Bickhart, Derek M., Rosen, Benjamin D., Kingan, Sarah B., Swale, Thomas, Thibaud-Nissen, Françoise, Murphy, Terence D., Young, Rachel, Lefevre, Lucas, Hume, David A., Collins, Andrew, Ajmone-Marsan, Paolo, Smith, Timothy P. L. and Williams, John L. (2019). Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity. Nature Communications, 10 (1) 260. doi: 10.1038/s41467-018-08260-0

A gene expression atlas of the domestic water buffalo (Bubalus bubalis)

Young, Rachel, Lefevre, Lucas, Bush, Stephen J., Joshi, Akshay, Singh, Salam H., Jadhav, Santosh K., Lisowski, Zofia M., Iamartino, Daniela, Summers, Kim M., Williams, John L., Archibald, Alan L., Gokhale, Suresh, Kumar, Satish and Hume, David A. (2019). A gene expression atlas of the domestic water buffalo (Bubalus bubalis). Frontiers in Genetics, 10 (JUN) 668. doi: 10.3389/fgene.2019.00668

Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293)

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 (APR) 818, 818. doi: 10.3389/fimmu.2019.00818

Negative curvature in graphical small cancellation groups

Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2019). Negative curvature in graphical small cancellation groups. Groups, Geometry, and Dynamics, 13 (2), 579-632. doi: 10.4171/GGD/498

A chicken bioreactor for efficient production of functional cytokines

Herron, Lissa R., Pridans, Clare, Turnbull, Matthew L., Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A., Gill, Andrew C. and Sang, Helen M. (2018). A chicken bioreactor for efficient production of functional cytokines. BMC Biotechnology, 18 (1) 82. doi: 10.1186/s12896-018-0495-1

Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken

Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Riggio, Valentina, Matika, Oswald, Harman, Kimberley, Hocking, Paul M., Bumstead, Nat, Hesketh, Pat, Archer, Andrew, Bishop, Stephen C., Kaiser, Pete, Tomley, Fiona M., Hume, David A., Smith, Adrian L., Blake, Damer P. and Psifidi, Androniki (2018). Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken. Frontiers in Genetics, 9 528, 528. doi: 10.3389/fgene.2018.00528

Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis

Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Psifidi, Androniki, Riggio, Valentina, Harman, Kimberley, Bishop, Stephen C., Kaiser, Pete, Abrahamsen, Mitchell S., Hawken, Rachel, Watson, Kellie A., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2018). Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis. Genetics Selection Evolution, 50 (1) 63, 63. doi: 10.1186/s12711-018-0433-7

Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors

Nirmal, Ajit J., Regan, Tim, Shih, Barbara B., Hume, David A., Sims, Andrew H. and Freeman, Tom C. (2018). Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunology Research, 6 (11), 1388-1400. doi: 10.1158/2326-6066.CIR-18-0342

ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages

Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246

Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus

Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J, Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2018). Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus. Journal of Immunology, 201 (9), 2683-2699. doi: 10.4049/jimmunol.1701783

Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity

Brown, S. M., Bush, S. J., Summers, K. M., Hume, D. A. and Lawrence, A. B. (2018). Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity. Behavioural Brain Research, 350, 6-15. doi: 10.1016/j.bbr.2018.05.015

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Scott, Charlotte L., T'Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W. F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan and Guilliams, Martin (2018). The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages. Immunity, 49 (2), 312-+. doi: 10.1016/j.immuni.2018.07.004

Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken

Bush, Stephen J., Freem, Lucy, MacCallum, Amanda J., O'Dell, Jenny, Wu, Chunlei, Afrasiabi, Cyrus, Psifidi, Androniki, Stevens, Mark P., Smith, Jacqueline, Summers, Kim M. and Hume, David A. (2018). Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken. BMC Genomics, 19 (1) 594. doi: 10.1186/s12864-018-4972-7

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663

Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing

Pandit, Ramesh J., Hinsu, Ankit T., Patel, Namrata V., Koringa, Prakash G., Jakhesara, Subhash J., Thakkar, Jalpa R., Shah, Tejas M., Limon, Georgina, Psifidi, Androniki, Guitian, Javier, Hume, David A., Tomley, Fiona M., Rank, Dharamshibhai N., Raman, M., Tirumurugaan, K. G., Blake, Damer P. and Joshi, Chaitanya G. (2018). Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing. Microbiome, 6 (1) 115. doi: 10.1186/s40168-018-0501-9

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19 (6), 625-635. doi: 10.1038/s41590-018-0111-5

An update on equine postoperative ileus: definitions, pathophysiology and management

Lisowski, Z. M., Pirie, R. S., Blikslager, A. T., Lefebvre, D., Hume, D. A. and Hudson, N. P. H. (2018). An update on equine postoperative ileus: definitions, pathophysiology and management. Equine Veterinary Journal, 50 (3), 292-303. doi: 10.1111/evj.12801

Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome

Bush, Stephen J., Muriuki, Charity, McCulloch, Mary E. B., Farquhar, Iseabail L., Clark, Emily L. and Hume, David A. (2018). Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. Genetics Selection Evolution, 50 (1) 20. doi: 10.1186/s12711-018-0391-0

The preterm labor associated ADAMTS2 gene is induced by glucocorticoids

Jubb, Alasdair W., Hofer, Thomas P., Hume, David A. and Ziegler-Heitbrock, Loems (2018). The preterm labor associated ADAMTS2 gene is induced by glucocorticoids. American Journal of Obstetrics and Gynecology, 219 (1), 122-123. doi: 10.1016/j.ajog.2018.03.024

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A. and Mabbott, Neil A. (2018). The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nature Communications, 9 (1) 1272, 1272. doi: 10.1038/s41467-018-03638-6

Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system

Hawley, Catherine A., Rojo, Rocio, Raper, Anna, Sauter, Kristin A., Lisowski, Zofia M., Grabert, Kathleen, Bain, Calum C., Davis, Gemma M., Louwe, Pieter A., Ostrowski, Michael C., Hume, David A., Pridans, Clare and Jenkins, Stephen J. (2018). Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system. Journal of Immunology, 200 (6), 2209-2223. doi: 10.4049/jimmunol.1701488

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats

Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

Baillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A. ... Hume, David A. (2018). Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 (3) e1005934, e1005934. doi: 10.1371/journal.pcbi.1005934

Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages

Regan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018). Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 (4), 681-692. doi: 10.1002/JLB.3A0617-261R

Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder

Leday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T., MRC Immunopsychiatry Consortium, Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert ... Henderson, Robbie (2018). Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biological Psychiatry, 83 (1), 70-80. doi: 10.1016/j.biopsych.2017.01.021

Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages

Young, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E.B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L. and Hume, David A. (2018). Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages. ImmunoHorizons, 2 (1), 27-37. doi: 10.4049/immunohorizons.1700073

Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci

Jubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017). Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 (11), 3022-3031. doi: 10.1016/j.celrep.2017.11.053

The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates

Hume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio and Pridans, Clare (2017). The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates. Scientific Reports, 7 (1) 17115, 1-10. doi: 10.1038/s41598-017-15999-x

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Farro, Giovanna, Stakenborg, Michelle, Gomez-Pinilla, Pedro J., Labeeuw, Evelien, Goverse, Gera, Giovangiulio, Martina Di, Stakenborg, Nathalie, Meroni, Elisa, D'Errico, Francesca, Elkrim, Yvon, Laoui, Damya, Lisowski, Zofia M., Sauter, Kristin A., Hume, David A., Van Ginderachter, Jo A., Boeckxstaens, Guy E. and Matteoli, Gianluca (2017). CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. Gut, 66 (12), 2098-2109. doi: 10.1136/gutjnl-2016-313144

Groups with no coarse embeddings into hyperbolic groups

Hume, David and Sisto, Alessandro (2017). Groups with no coarse embeddings into hyperbolic groups. New York Journal of Mathematics, 23, 1657-1670. doi: 10.48550/arXiv.1702.03789

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033

Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology

Macdonald, Sarah E., Nolan, Matthew J., Harman, Kimberley, Boulton, Kay, Hume, David A., Tomley, Fiona M., Stabler, Richard A. and Blake, Damer P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12 (9) e0184890, 1-17. doi: 10.1371/journal.pone.0184890

A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

Clark, Emily L., Bush, Stephen J., McCulloch, Mary E. B., Farquhar, Iseabail L., Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C. Bruce, Freeman, Tom C., Summers, Kim M., Archibald, Alan L. and Hume, David A. (2017). A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics, 13 (9) e1006997, e1006997. doi: 10.1371/journal.pgen.1006997

The genomic architecture of mastitis resistance in dairy sheep

Banos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., Schulze, G., Arsenos, G., Hume, D. A. and Psifidi, A. (2017). The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18 (1) 624, 1-18. doi: 10.1186/s12864-017-3982-1

Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults

Bell, J. A., Kivimäki, M., Bullmore, E. T., Steptoe, A., Carvalho, L. A., Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zuszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil, Janssen, Wayne Drevets, Wittenberg, Gayle M., Sun, Yu, Jones, Declan, Bullmore, Edward, Khan, Shahid, Stylianou, Annie and Henderson, Robert B. (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry, 7 (8) e1208, e1208-e1208. doi: 10.1038/tp.2017.155

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112

Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus

Rojo, Rocio, Pridans, Clare, Langlais, David and Hume, David A. (2017). Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science, 131 (16), 2161-2182. doi: 10.1042/CS20170238

Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data

Summers, Kim M. and Hume, David A. (2017). Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. Journal of Leukocyte Biology, 102 (4), 1081-1092. doi: 10.1189/jlb.1A0417-150RR

Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries

Bush, Stephen J., McCulloch, Mary E.B., Summers, Kim M., Hume, David A. and Clark, Emily L. (2017). Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries. BMC Bioinformatics, 18 (1) 301, 1-12. doi: 10.1186/s12859-017-1714-9

Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions

Kwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017). Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 (MAR) 32. doi: 10.3389/fgene.2017.00032

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

Baillie, J. Kenneth, Arner, Erik, Daub, Carsten, De Hoon, Michiel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Faulkner, Geoffrey J., Wells, Christine A., Rehli, Michael, Pavli, Paul, Summers, Kim M., Hume, David A. and FANTOM Consortium (2017). Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease. PLoS Genetics, 13 (3) e1006641, 1-36. doi: 10.1371/journal.pgen.1006641

A continuum of expanders

Hume, David (2017). A continuum of expanders. Fundamenta Mathematicae, 238 (2), 143-152. doi: 10.4064/fm101-11-2016

Characterizations of Morse quasi-geodesics via superlinear divergence and sublinear contraction

Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2017). Characterizations of Morse quasi-geodesics via superlinear divergence and sublinear contraction. Documenta Mathematica, 22 (2017), 1193-1224. doi: 10.25537/dm.2017v22.1193-1224

Embedding mapping class groups into a finite product of trees

Hume, David (2017). Embedding mapping class groups into a finite product of trees. Groups, Geometry, and Dynamics, 11 (2), 613-647. doi: 10.4171/GGD/410

Stability and the Morse boundary:

Cordes, Matthew and Hume, David (2017). Stability and the Morse boundary:. Journal of the London Mathematical Society, 95 (3), 963-988. doi: 10.1112/jlms.12042

Professor Pete Kaiser 1964-2016

Stevens, Mark, Vervelde, Lonneke and Hume, David (2016). Professor Pete Kaiser 1964-2016. Avian Pathology, 45 (6), 683-684. doi: 10.1080/03079457.2016.1251745

Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes

Psifidi, Androniki, Banos, Georgios, Matika, Oswald, Desta, Takele T., Bettridge, Judy, Hume, David A., Dessie, Tadelle, Christley, Rob, Wigley, Paul, Hanotte, Olivier and Kaiser, Pete (2016). Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes. Genetics Selection Evolution, 48 (1) 74. doi: 10.1186/s12711-016-0252-7

A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep

Pridans, Clare, Davis, Gemma M., Sauter, Kristin A., Lisowski, Zofia M., Corripio-Miyar, Yolanda, Raper, Anna, Lefevre, Lucas, Young, Rachel, McCulloch, Mary E., Lillico, Simon, Milne, Elspeth, Whitelaw, Bruce and Hume, David A. (2016). A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep. Journal of Immunology, 197 (6), 2297-2305. doi: 10.4049/jimmunol.1502336

Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs

Sauter, Kristin A., Waddell, Lindsey A., Lisowski, Zofia M., Young, Rachel, Lefevre, Lucas, Davis, Gemma M., Clohisey, Sara M., McCulloch, Mary, Magowan, Elizabeth, Mabbott, Neil A., Summers, Kim M. and Hume, David A. (2016). Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311 (3), G533-G547. doi: 10.1152/ajpgi.00116.2016

Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016). Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 (1), 7-16. doi: 10.1038/icb.2016.74

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009

Comparative transcriptome analysis of equine alveolar macrophages

Karagianni, A. E., Kapetanovic, R., Summers, K. M., Mcgorum, B. C., Hume, D. A. and Pirie, R. S. (2016). Comparative transcriptome analysis of equine alveolar macrophages. Equine Veterinary Journal, 49 (3), 375-382. doi: 10.1111/evj.12584

Functional annotation of the T-cell immunoglobulin mucin family in birds

Hu, Tuanjun, Wu, Zhiguang, Vervelde, Lonneke, Rothwell, Lisa, Hume, David A. and Kaiser, Pete (2016). Functional annotation of the T-cell immunoglobulin mucin family in birds. Immunology, 148 (3), 287-303. doi: 10.1111/imm.12607

Transcriptional regulation and macrophage differentiation

Hume, David A., Summers, Kim M. and Rehli, Michael (2016). Transcriptional regulation and macrophage differentiation. Microbiology Spectrum, 4 (3) MCHD-0024-2015, 1-19. doi: 10.1128/microbiolspec.MCHD-0024-2015

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023

Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA

Wu, Zhiguang, Hu, Tuanjun, Rothwell, Lisa, Vervelde, Lonneke, Kaiser, Pete, Boulton, Kay, Nolan, Matthew J., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2016). Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63, 206-212. doi: 10.1016/j.dci.2016.04.016

Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages

Jubb, Alasdair W., Young, Robert S., Hume, David A. and Bickmore, Wendy A. (2016). Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages. Journal of Immunology, 196 (2), 813-822. doi: 10.4049/jimmunol.1502009

The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens

Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P. M., Kuo, R., Smith, J., Hocking, P. M., Salmon, N., Jones, M. A., Hume, D. A., Banos, G., Stevens, M. P. and Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17 (293) 293. doi: 10.1186/s12864-016-2612-7

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S. ... Hayashizaki, Yoshihide (2015). The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 (12) e1002315, e1002315. doi: 10.1371/journal.pbio.1002315

CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure

Stutchfield, Benjamin M., Antoine, Daniel J., Mackinnon, Alison C., Gow, Deborah J., Bain, Calum C., Hawley, Catherine A., Hughes, Michael J., Francis, Benjamin, Wojtacha, Davina, Man, Tak Y., Dear, James W., Devey, Luke R., Mowat, Alan M., Pollard, Jeffrey W., Park, B. Kevin, Jenkins, Stephen J., Simpson, Kenneth J., Hume, David A., Wigmore, Stephen J. and Forbes, Stuart J. (2015). CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology, 149 (7), 1896-1909. doi: 10.1053/j.gastro.2015.08.053

Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome

Robert, Christelle, Kapetanovic, Ronan, Beraldi, Dario, Watson, Mick, Archibald, Alan L. and Hume, David A. (2015). Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome. BMC Genomics, 16 (1) 970, 970.1-970.17. doi: 10.1186/s12864-015-2111-2

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 (304) 304ra142, 1-10. doi: 10.1126/scitranslmed.aaa3863

The many alternative faces of macrophage activation

Hume, David A. (2015). The many alternative faces of macrophage activation. Frontiers in Immunology, 6 (JUL) 370. doi: 10.3389/fimmu.2015.00370

Immune surveillance of the lung by migrating tissue monocytes

Rodero, Mathieu P., Poupel, Lucie, Loyher, Pierre-Louis, Hamon, Pauline, Licata, Fabrice, Pessel, Charlotte, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2015). Immune surveillance of the lung by migrating tissue monocytes. eLife, 4 (JULY 2015) e07847, 1-23. doi: 10.7554/eLife.07847

Direct embeddings of relatively hyperbolic groups with optimal ℓp compression exponent

Hume, David (2015). Direct embeddings of relatively hyperbolic groups with optimal ℓp compression exponent. Journal fur die Reine und Angewandte Mathematik, 2015 (703), 147-172. doi: 10.1515/crelle-2013-0040

Plant breeding: UK bioscientists push for crop policy

Hume, David (2015). Plant breeding: UK bioscientists push for crop policy. Nature, 521 (7553), 423-423. doi: 10.1038/521423c

Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response

Aitken, Stuart, Magi, Shigeyuki, Alhendi, Ahmad M. N., Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Arner, Erik, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Khachigian, Levon M., Okada-Hatakeyama, Mariko, Semple, Colin A., FANTOM Consortium, Forrest, Alistair R. R., Sandelin, Albin, Daub, Carsten O., Wells, Christine, Hume, David A., Arner, Erik, Kawaji, Hideya, Summers, Kim M., Vitting-Seerup, Kristoffer, Carninci, Piero, Andersson, Robin, Hayashizaki, Yoshihide and Yumoto, Noriko (2015). Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response. PLoS Computational Biology, 11 (4) e1004217, e1004217. doi: 10.1371/journal.pcbi.1004217

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Arner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E. ... Hayashizaki, Yoshihide (2015). Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 (6225), 1010-1014. doi: 10.1126/science.1259418

Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells

Joshi, Anagha, Pooley, Christopher, Freeman, Tom C., Lennartsson, Andreas, Babina, Magda, Schmidl, Christian, Geijtenbeek, Teunis, Michoel, Tom, Severin, Jessica, Itoh, Masayoshi, Lassmann, Timo, Kawaji, Hideya, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair R. R., Rehli, Michael and Hume, David A. (2015). Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells. Journal of Leukocyte Biology, 97 (5), 985-995. doi: 10.1189/jlb.6TA1014-477RR

Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma

Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen M., Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., Van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. (2015). Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25 (5), 577-588. doi: 10.1016/j.cub.2014.12.059

A transcriptional perspective on human macrophage biology

Schultze, Joachim L., Freeman, Tom, Hume, David A. and Latz, Eicke (2015). A transcriptional perspective on human macrophage biology. Seminars in Immunology, 27 (1), 44-50. doi: 10.1016/j.smim.2015.02.001

The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor

Garceau, Valerie, Balic, Adam, Garcia-Morales, Carla, Sauter, Kristin A., McGrew, Mike J., Smith, Jacqueline, Vervelde, Lonneke, Sherman, Adrian, Fuller, Troy E., Oliphant, Theodore, Shelley, John A., Tiwari, Raksha, Wilson, Thomas L., Chintoan-Uta, Cosmin, Burt, Dave W., Stevens, Mark P., Sang, Helen M. and Hume, David A. (2015). The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor. BMC Biology, 13 (1) 12, 12.1-12.17. doi: 10.1186/s12915-015-0121-9

'Recognised veterinary practice' in the context of clinical field trials

Nanjiani, Ian, Hume, David, Fitzpatrick, Julie and Murray, John (2015). 'Recognised veterinary practice' in the context of clinical field trials. Veterinary Record, 176 (21), 552-552. doi: 10.1136/vr.h2718

Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages

Garcia-Morales, Carla, Nandi, Sunil, Zhao, Debiao, Sauter, Kristin A., Vervelde, Lonneke, McBride, Derek, Sang, Helen M., Clinton, Mike and Hume, David A. (2015). Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages. Journal of Immunology, 194 (5), 2338-2344. doi: 10.4049/jimmunol.1401982

Exome sequencing: current and future perspectives

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan, Deeb, Nader and Watson, Mick (2015). Exome sequencing: current and future perspectives. G3: Genes, Genomes, Genetics, 5 (8), 1543-1550. doi: 10.1534/g3.115.018564

Identification of low-confidence regions in the pig reference genome (Sscrofa10.2)

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan L., Deeb, Nader and Watson, Mick (2015). Identification of low-confidence regions in the pig reference genome (Sscrofa10.2). Frontiers in Genetics, 6 (NOV) 338. doi: 10.3389/fgene.2015.00338

Orthogonal forms of Kac-moody groups are acylindrically hyperbolic

Caprace, Pierre-Emmanuel and Hume, David (2015). Orthogonal forms of Kac-moody groups are acylindrically hyperbolic. Annales de l'Institut Fourier, 65 (6), 2613-2640. doi: 10.5802/aif.2998

Third Report on Chicken Genes and Chromosomes 2015:

Schmid, Michael, Smith, Jacqueline, Burt, David W., Aken, Bronwen L., Antin, Parker B., Archibald, Alan L., Ashwell, Chris, Blackshear, Perry J., Boschiero, Clarissa, Brown, C. Titus, Burgess, Shane C., Cheng, Hans H., Chow, William, Coble, Derrick J., Cooksey, Amanda, Crooijmans, Richard P. M. A., Damas, Joana, Davis, Richard V.N., De Koning, Dirk-Jan, Delany, Mary E., Derrien, Thomas, Desta, Takele T., Dunn, Ian C., Dunn, Matthew, Ellegren, Hans, Eöry, Lél, Erb, Ionas, Farré, Marta, Fasold, Mario ... Zhou, Huaijun (2015). Third Report on Chicken Genes and Chromosomes 2015:. Cytogenetic and Genome Research, 145 (2), 78-179. doi: 10.1159/000430927

Characterisation of a novel fc conjugate of macrophage colony-stimulating factor

Gow, Deborah J, Sauter, Kristin A., Pridans, Clare, Moffat, Lindsey, Sehgal, Anuj, Stutchfield, Ben M., Raza, Sobia, Beard, Philippa M., Tsai, Yi Ting, Bainbridge, Graeme, Boner, Pamela L., Fici, Greg, Garcia-Tapia, David, Martin, Roger A., Oliphant, Theodore, Shelly, John A., Tiwari, Raksha, Wilson, Thomas L., Smith, Lee B., Mabbott, Neil A. and Hume, David A. (2014). Characterisation of a novel fc conjugate of macrophage colony-stimulating factor. Molecular Therapy, 22 (9), 1580-1592. doi: 10.1038/mt.2014.112

Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115)

Moffat, L., Rothwell, L., Garcia-Morales, C., Sauter, K. A., Kapetanovic, R., Gow, D. J. and Hume, D. A. (2014). Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). Developmental and Comparative Immunology, 47 (1), 123-128. doi: 10.1016/j.dci.2014.07.001

Transcriptomic analysis of mononuclear phagocyte differentiation and activation

Hume, David A. and Freeman, Tom C. (2014). Transcriptomic analysis of mononuclear phagocyte differentiation and activation. Immunological Reviews, 262 (1), 74-84. doi: 10.1111/imr.12211

Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells

Garcia-Morales, Carla, Rothwell, Lisa, Moffat, Lindsey, Garceau, Valerie, Balic, Adam, Sang, Helen M., Kaiser, Pete and Hume, David A. (2014). Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells. Developmental and Comparative Immunology, 42 (2), 278-285. doi: 10.1016/j.dci.2013.09.011

The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Bain, Calum C., Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M., Davies, Claire L., Donaldson, David S., Renault, Kathleen, McColl, Barry W., Mowat, Alan M., Serrels, Alan, Frame, Margaret C., Mabbott, Neil A. and Hume, David A. (2014). The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration. PLoS ONE, 9 (8) e105429, 1-12. doi: 10.1371/journal.pone.0105429

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Raza, Sobia, Barnett, Mark W., Barnett-Itzhaki, Zohar, Amit, Ido, Hume, David A. and Freeman, Tom C. (2014). Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. Journal of Leukocyte Biology, 96 (2), 167-183. doi: 10.1189/jlb.6HI0313-169R

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B. and Hume, David A. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 96 (2), 265-274. doi: 10.1189/jlb.2A0114-006R

Design and development of exome capture sequencing for the domestic pig (Sus scrofa)

Robert, Christelle, Fuentes-Utrilla, Pablo, Troup, Karen, Loecherbach, Julia, Turner, Frances, Talbot, Richard, Archibald, Alan L., Mileham, Alan, Deeb, Nader, Hume, David A. and Watson, Mick (2014). Design and development of exome capture sequencing for the domestic pig (Sus scrofa). BMC Genomics, 15 (1) 550. doi: 10.1186/1471-2164-15-550

Transcription and enhancer profiling in human monocyte subsets

Schmidl, Christian, Renner, Kathrin, Peter, Katrin, Eder, Ruediger, Lassmann, Timo, Balwierz, Piotr J., Itoh, Masayohshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Andreesen, Reinhard, Hume, David A., Hoffmann, Petra, Forrest, Alistair R. R., Kreutz, Marina P., Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014). Transcription and enhancer profiling in human monocyte subsets. Blood, 123 (17), e90-e99. doi: 10.1182/blood-2013-02-484188

An atlas of active enhancers across human cell types and tissues

Andersson, Robin, Gebhard, Claudia, Miguel-Escalada, Irene, Hoof, Ilka, Bornholdt, Jette, Boyd, Mette, Chen, Yun, Zhao, Xiaobei, Schmidl, Christian, Suzuki, Takahiro, Ntini, Evgenia, Arner, Erik, Valen, Eivind, Li, Kang, Schwarzfischer, Lucia, Glatz, Dagmar, Raithel, Johanna, Lilje, Berit, Rapin, Nicolas, Bagger, Frederik Otzen, Jørgensen, Mette, Andersen, Peter Refsing, Bertin, Nicolas, Rackham, Owen, Burroughs, A. Maxwell, Baillie, J. Kenneth, Ishizu, Yuri, Shimizu, Yuri, Furuhata, Erina ... Sandelin, Albin (2014). An atlas of active enhancers across human cell types and tissues. Nature, 507 (7493), 455-461. doi: 10.1038/nature12787

Transcriptional switching in macrophages associated with the peritoneal foreign body response

Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 (6), 518-526. doi: 10.1038/icb.2014.19

Network analysis reveals distinct clinical syndromes underlying acute mountain sickness

Hall, David P., MacCormick, Ian J. C., Phythian-Adams, Alex T., Rzechorzek, Nina M., Hope-Jones, David, Cosens, Sorrel, Jackson, Stewart, Bates, Matthew G. D., Collier, David J., Hume, David A., Freeman, Thomas, Thompson, A. A. Roger and Baillie, John Kenneth (2014). Network analysis reveals distinct clinical syndromes underlying acute mountain sickness. PLoS ONE, 9 (1) e81229, e81229. doi: 10.1371/journal.pone.0081229

Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals

Pridans, Clare, Lillico, Simon, Whitelaw, Bruce and Hume, David A. (2014). Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals. Molecular Therapy - Methods and Clinical Development, 1 14010, 14010. doi: 10.1038/mtm.2014.10

A promoter-level mammalian expression atlas

Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab ... Hayashizaki, Yoshihide (2014). A promoter-level mammalian expression atlas. Nature, 507 (7493), 462-470. doi: 10.1038/nature13182

Homeostasis in the mononuclear phagocyte system

Jenkins, Stephen J. and Hume, David A. (2014). Homeostasis in the mononuclear phagocyte system. Trends in Immunology, 35 (8), 358-367. doi: 10.1016/j.it.2014.06.006

Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage

Balic, Adam, Garcia-Morales, Carla, Vervelde, Lonneke, Gilhooley, Hazel, Sherman, Adrian, Garceau, Valerie, Gutowska, Maria W., Burt, David W., Kaiser, Pete, Hume, David A. and Sang, Helen M. (2014). Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage. Development, 141 (16), 3255-3265. doi: 10.1242/dev.105593

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function

Pridans, Clare, Sauter, Kristin A., Baer, Kristin, Kissel, Holger and Hume, David A. (2013). CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function. Scientific Reports, 3 (1) 3013. doi: 10.1038/srep03013

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

Jenkins, Stephen J., Ruckerl, Dominik, Thomas, Graham D., Hewitson, James P., Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M., Hume, David A. and Allen, Judith E. (2013). IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. Journal of Experimental Medicine, 210 (11), 2477-2491. doi: 10.1084/jem.20121999

The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages

Karagianni, Anna E., Kapetanovic, Ronan, McGorum, Bruce C., Hume, David A. and Pirie, Scott R. (2013). The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages. Veterinary Immunology And Immunopathology, 155 (4), 219-228. doi: 10.1016/j.vetimm.2013.07.003

An expression atlas of human primary cells: inference of gene function from coexpression networks

Mabbott, Neil A., Baillie, J. K., Brown, Helen, Freeman, Tom C. and Hume, David A. (2013). An expression atlas of human primary cells: inference of gene function from coexpression networks. BMC Genomics, 14 (1) 632. doi: 10.1186/1471-2164-14-632

CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice

Jacquelin, Sébastien, Licata, Fabrice, Dorgham, Karim, Hermand, Patricia, Poupel, Lucie, Guyon, Elodie, Deterre, Philippe, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2013). CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice. Blood, 122 (5), 674-683. doi: 10.1182/blood-2013-01-480749

Embedding universal covers of graph manifolds in products of trees

Hume, David and Sisto, Alessandro (2013). Embedding universal covers of graph manifolds in products of trees. Proceedings of the American Mathematical Society, 141 (10), 3337-3340. doi: 10.1090/S0002-9939-2013-11669-2

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide

Kapetanovic, Ronan, Fairbairn, Lynsey, Downing, Alison, Beraldi, Dario, Sester, David P., Freeman, Tom C., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2013). The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. Bmc Genomics, 14 (1) 581. doi: 10.1186/1471-2164-14-581

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment

Doig, Tamasin N., Hume, David A., Theocharidis, Thanasis, Goodlad, John R., Gregory, Christopher D. and Freeman, Tom C. (2013). Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. BMC Genomics, 14 (1) 469. doi: 10.1186/1471-2164-14-469

Comparative analysis of monocyte subsets in the pig

Fairbairn, Lynsey, Kapetanovic, Ronan, Beraldi, Dario, Sester, David P., Tuggle, Chris K., Archibald, Alan L. and Hume, David A. (2013). Comparative analysis of monocyte subsets in the pig. Journal of Immunology, 190 (12), 6389-6396. doi: 10.4049/jimmunol.1300365

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli

Dave, Richa K., Dinger, Marcel E., Andrew, Megan, Askarian-Amiri, Marjan, Hume, David A. and Kellie, Stuart (2013). Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli. PLoS One, 8 (6) e68306, e68306.1-e68306.13. doi: 10.1371/journal.pone.0068306

Erratum: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis [Immunity 38 (2013) 79-91]

Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, DavidA., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Erratum: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis [Immunity 38 (2013) 79-91]. Immunity, 38 (5), 1073-1079. doi: 10.1016/j.immuni.2013.05.008

Structural and functional annotation of the porcine immunome

Dawson, Harry D., Loveland, Jane E., Pascal, Geraldine, Gilbert, James G. R., Uenishi, Hirohide, Mann, Katherine M., Sang, Yongming, Zhang, Jie, Carvalho-Silva, Denise, Hunt, Toby, Hardy, Matthew, Hu, Zhiliang, Zhao, Shu-Hong, Anselmo, Anna, Shinkai, Hiroki, Chen, Celine, Badaoui, Bouabid, Berman, Daniel, Amid, Clara, Kay, Mike, Lloyd, David, Snow, Catherine, Morozumi, T., Cheng, Ryan Pei-Yen, Bystrom, Megan, Kapetanovic, Ronan, Schwartz, John C., Kataria, Ranjit, Astley, Matthew ... Tuggle, Christopher K. (2013). Structural and functional annotation of the porcine immunome. BMC Genomics, 14 (1) 332, 332.1-332.16. doi: 10.1186/1471-2164-14-332

Can DCs be distinguished from macrophages by molecular signatures?

Hume, David A., Mabbott, Neil, Raza, Sobia and Freeman, Tom C. (2013). Can DCs be distinguished from macrophages by molecular signatures?. Nature Immunology, 14 (3), 187-189. doi: 10.1038/ni.2516

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

Gow, Deborah J., Garceau, Valerie, Pridans, Clare, Gow, Adam G., Simpson, Kerry E., Gunn-Moore, Danielle and Hume, David A. (2013). Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 61 (2), 630-638. doi: 10.1016/j.cyto.2012.11.014

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, David A., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity, 38 (1), 79-91. doi: 10.1016/j.immuni.2012.12.001

The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus

Sauter, Kristin A., Bouhlel, M. Amine, O'Neal, Julie, Sester, David P., Tagoh, Hiromi, Ingram, Richard M. I, Pridans, Clare, Bonifer, Constanze and Hume, David A. (2013). The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus. PLoS One, 8 (1) e54935, e54935. doi: 10.1371/journal.pone.0054935

Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34

Gow, Deborah J., Garceau, Valerie, Kapetanovic, Ronan, Sester, David P., Fici, Greg J., Shelly, John A., Wilson, Thomas L. and Hume, David A. (2012). Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34. Cytokine, 60 (3), 793-805. doi: 10.1016/j.cyto.2012.08.008

A gene expression atlas of the domestic pig

Freeman, Tom C., Ivens, Alasdair, Baillie, J. Kenneth, Beraldi, Dario, Barnett, Mark W., Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I., Summers, Kim M., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2012). A gene expression atlas of the domestic pig. BMC Biology, 10 (9) 90. doi: 10.1186/1741-7007-10-90

Prediction of altered 3 '-UTR miRNA-binding sites from RNA-seq data: the swine leukocyte antigen complex (SLA) as a model region

Ahanda, Marie-Laure Endale, Fritz, Eric R., Estelle, Jordi, Hu, Zhi-Liang, Madsen, Ole, Groenen, Martien A. M., Beraldi, Dario, Kapetanovic, Ronan, Hume, David A., Rowland, Robert R. R., Lunney, Joan K., Rogel-Gaillard, Claire, Reecy, James M. and Giuffra, Elisabetta (2012). Prediction of altered 3 '-UTR miRNA-binding sites from RNA-seq data: the swine leukocyte antigen complex (SLA) as a model region. Plos One, 7 (11), e48607.1-e48607.11. doi: 10.1371/journal.pone.0048607

Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes

Hume, David A. (2012). Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes. Journal of Leukocyte Biology, 92 (3), 433-444. doi: 10.1189/jlb.0312166

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt, Aaron R., Clare, Simon, Pertel, Thomas, John, Sinu P., Wash, Rachael S., Smith, Sarah E., Chin, Christopher R., Feeley, Eric M., Sims, Jennifer S., Adams, David J., Wise, Helen M., Kane, Leanne, Goulding, David, Digard, Paul, Anttila, Verneri, Baillie, J. Kenneth, Walsh, Tim S., Hume, David A., Palotie, Aarno, Xue, Yali, Colonna, Vincenza, Tyler-Smith, Chris, Dunning, Jake, Gordon, Stephen B., Smyth, Rosalind L., Openshaw, Peter J., Dougan, Gordon, Brass, Abraham L. and Kellam, Paul (2012). IFITM3 restricts the morbidity and mortality associated with influenza. Nature, 484 (7395), 519-523. doi: 10.1038/nature10921

Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide

Kapetanovic, Ronan, Fairbairn, Lynsey, Beraldi, Dario, Sester, David P., Archibald, Alan L., Tuggle, Christopher K. and Hume, David A. (2012). Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. The Journal of Immunology, 188 (7), 3382-3394. doi: 10.4049/jimmunol.1102649

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

Hume, David A. and MacDonald, Kelli P. A. (2012). Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood, 119 (8), 1810-1820. doi: 10.1182/blood-2011-09-379214

Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages

Bradford, Barry M., Sester, David P., Hume, David A. and Mabbott, Neil A. (2011). Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. Immunobiology, 216 (11), 1228-1237. doi: 10.1016/j.imbio.2011.08.006

Editorial

Hume, David A. (2011). Editorial. Immunobiology, 216 (11), 1163-1. doi: 10.1016/j.imbio.2011.08.010

Macrophages.com: an on-line community resource for innate immunity research

Robert, Christelle, Lu, Xiang, Law, Andrew, Freeman, Tom C. and Hume, David A. (2011). Macrophages.com: an on-line community resource for innate immunity research. Immunobiology, 216 (11), 1203-1211. doi: 10.1016/j.imbio.2011.07.025

Somatic retrotransposition alters the genetic landscape of the human brain

Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan. Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A. and Faulkner, Geoffrey J. (2011). Somatic retrotransposition alters the genetic landscape of the human brain. Nature, 479 (7374), 534-537. doi: 10.1038/nature10531

Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher , Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A. and Ricardo, Sharon D. (2011). Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. The American Journal of Pathology, 179 (3), 1243-1256. doi: 10.1016/j.ajpath.2011.05.037

Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011). Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 (7), 1517-1532. doi: 10.1002/jbmr.354

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, James A., Pope, Caroline, Wojtacha, Davina, Robson, Andrew J., Gordon-Walker, Timothy T., Hartland, Stephen, Ramachandran, Prakash, Van Deemter, Marielle, Hume, David A., Iredale, John P. and Forbes, Stuart J. (2011). Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology, 53 (6), 2003-2015. doi: 10.1002/hep.24315

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P. and Hume, David A. (2011). The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. Journal of Leukocyte Biology, 89 (6), 855-871. doi: 10.1189/jlb.1110607

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

Hume, David A. (2011). Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. Journal of Leukocyte Biology, 89 (4), 525-538. doi: 10.1189/jlb.0810472

The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes

Roberts, Tara L., Dunn, Jasmyn A., Sweet, Matthew J., Hume, David A. and Stacey, Katryn J. (2011). The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. Molecular Immunology, 48 (8), 1027-1034. doi: 10.1016/j.molimm.2011.01.011

The future of animal production: improving productivity and sustainability

Hume, D. A., Whitelaw, C. B. A. and Archibald, A. L. (2011). The future of animal production: improving productivity and sustainability. Journal of Agricultural Science, 149 (S1), 9-16. doi: 10.1017/S0021859610001188

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723

An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation

MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296

Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome

Summers, Kim M., Raza, Sobia, van Nimwegen, Erik, Freeman, Thomas C. and Hume, David A. (2010). Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome. European Journal of Human Genetics, 18 (11), 1209-1215. doi: 10.1038/ejhg.2010.91

CSF-1, IGF-1, and the control of postnatal growth and development

Gow, Deborah J., Sester, David P. and Hume, David A. (2010). CSF-1, IGF-1, and the control of postnatal growth and development. Journal of Leukocyte Biology, 88 (3), 475-481. doi: 10.1189/jlb.0310158

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

Mabbott, Neil A., Baillie, J. Kenneth, Hume, David A. and Freeman, Tom C. (2010). Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology, 215 (9-10), 724-736. doi: 10.1016/j.imbio.2010.05.012

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations

Hume, David A., Summers, Kim M., Raza, Sobia, Baillie, J. Kenneth and Freeman, Thomas C. (2010). Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations. Genomics, 95 (6), 328-338. doi: 10.1016/j.ygeno.2010.03.002

A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice

Ovchinnikov, Dmitry A., DeBats, Claire E. E., Sester, David P., Sweet, Matthew J. and Hume, David A. (2010). A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. Journal of Leukocyte Biology, 87 (5), 815-822. doi: 10.1189/jlb.0809557

Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products

Garceau, Valerie, Smith, Jacqueline, Paton, Ian R., Davey, Megan, Fares, Mario A., Sester, David P., Burt, David W. and Hume, David A. (2010). Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. Journal of Leukocyte Biology, 87 (5), 753-764. doi: 10.1189/jlb.0909624

Unravelling mononuclear phagocyte heterogeneity

Geissmann, Frederic, Gordon, Siamon, Hume, David A., Mowat, Allan M. and Randolph, Gwendalyn J. (2010). Unravelling mononuclear phagocyte heterogeneity. Nature Reviews Immunology, 10 (6), 453-460. doi: 10.1038/nri2784

An atlas of combinatorial transcriptional regulation in mouse and man

Ravasi, Timothy, Suzuki, Harukazu, Cannistraci, Carlo Vittorio, Katayama, Shintaro, Bajic, Vladimir B., Tan, Kai, Akalin, Altuna, Schmeier, Sebastian, Kanamori-Katayama, Mutsumi, Bertin, Nicolas, Carninci, Piero, Daub, Carsten O., Forrest, Alistair R.R., Gough, Julian, Grimmond, Sean, Han, Jung-Hoon, Hashimoto, Takehiro, Hide, Winston, Hofmann, Oliver, Kamburov, Atanas, Kaur, Mandeep, Kawaji, Hideya, Kubosaki, Atsutaka, Lassmann, Timo, van Nimwegen, Erik, MacPherson, Cameron Ross, Ogawa, Chihiro, Radovanovic, Aleksandar, Schwartz, Ariel ... Hayashizaki, Yoshihide (2010). An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 141 (2), 369. doi: 10.1016/j.cell.2010.04.004

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae

Ripoll, Vera M., Kadioglu, Aras, Cox, Roger, Hume, David A. and Denny, Paul (2010). Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. Journal of Leukocyte Biology, 87 (4), 735-741. doi: 10.1189/jlb.0509359

An atlas of combinatorial transcriptional regulation in mouse and man

Ravasi, Timothy, Suzuki, Harukazu, Cannistraci, Carlo Vittorio, Katayama, Shintaro, Bajic, Vladimir B., Tan, Kai, Akalin, Altuna, Schmeier, Sebastian, Kanamori-Katayama, Mutsumi, Carninci, Piero, Bertin, Nicholas, Daub, Cartsten O., Forrest, Alistair R. R., Gough, Julian, Grimmond, Sean, Han, Jung-Hoon, Hashimoto, Takehiro, Hide, Winston, Hofmann, Oliver, Kamburov, Atanas, Kaur, Mandeep, Kawaji, Hideya, Kubosaki, Atsutaka, Lassmann, Timo, van Nimwegen, Erik, MacPherson, Cameron Ross, Ogawa, Chihiro, Radovanovic, Aleksandar, Schwartz, Ariel ... Hayashizaki, Yoshihide (2010). An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 140 (5), 744-752. doi: 10.1016/j.cell.2010.01.044

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

Deng, Lin, Zhou, Jin-Feng, Sellers, Rani S., Li, Jiu-Feng, Nguyen, Andrew V., Wang, Yubao, Orlofsky, Amos, Liu, Qiang, Hume, David A., Pollard, Jeffrey W., Augenlicht, Leonard and Lin, Elaine Y. (2010). A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. American Journal of Pathology, 176 (2), 952-967. doi: 10.2353/ajpath.2010.090622

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase

Weber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010). Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 (2), 447-454. doi: 10.1016/j.ejmech.2009.10.025

Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response

Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010). Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 (1), 369-380. doi: 10.2353/ajpath.2010.090545

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

Forrest, A. R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., De Hoon, M. J.L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia, 24 (2), 460-466. doi: 10.1038/leu.2009.246

Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival

Lattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012

Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1

Summers, Kim M., Bokil, Nilesh J., Baisden, John M., West, Malcolm J., Sweet, Matthew J., Raggatt, Liza J. and Hume, David A. (2009). Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1. Genomics, 94 (4), 233-240. doi: 10.1016/j.ygeno.2009.06.005

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration

Ebert, Stefanie, Weigelt, Karin, Walczak, Yana, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009). Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. Journal of Neurochemistry, 110 (6), 1863-1875. doi: 10.1111/j.1471-4159.2009.06286.x

Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)

Taft, Ryan J., Glazov, Evgeny A., Cloonan, Nicole, Simons, Cas, Stephen, Stuart, Faulkner, Geoffrey J., Lassmann, Timo, Forrest, Alistair R. R., Grimmond, Sean M., Schroder, Kate, Irvine, Katharine, Arakawa, Takahiro, Nakamura, Mari, Kubosaki, Atsutaka, Hayashida, Kengo, Kawazu, Chika, Murata, Mitsuyoshi, Nishiyori, Hiromi, Fukuda, Shiro, Kawai, Jun, Daub, Carsten O., Hume, David A., Suzuki, Harukazu, Orlando, Valerio, Carninci, Piero, Hayashizaki, Yoshihide and Mattick, John S. (2009). Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009). Nature Genetics, 41 (7), 859-859. doi: 10.1038/ng0709-859a

Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling

Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009). Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 (3), 326-337. doi: 10.1111/j.1365-2567.2008.02979.x

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

Dave, R. K., Hume, D. A., Elsegood, C and Kellie, S (2009). CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Experimental Cell Research, 315 (10), 1734-1744. doi: 10.1016/j.yexcr.2009.02.023

The regulated retrotransposon transcriptome of mammalian cells

Faulkner, Geoffrey J., Kimura, Yasumasa, Daub, Carsten O., Wani, Shivangi, Plessy, Charles, Irvine, Katharine M., Schroder, Kate, Cloonan, Nicole, Steptoe, Anita L., Lassmann, Timo, Waki, Kazunori, Hornig, Nadine, Arakawa, Takahiro, Takahashi, Hazuki, Kawai, Jun, Forrest, Alistair R. R., Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A., Orlando, Valerio, Grimmond, Sean M. and Carninci, Piero (2009). The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics, 41 (5), 563-571. doi: 10.1038/ng.368

Tiny RNAs associated with transcription start sites in animals

Taft, RJ, Glazov, EA, Cloonan, N, Simons, C, Stephen, S, Faulkner, GJ, Lassmann, T, Forrest, ARR, Grimmond, SM, Schroder, K, Irvine, K, Arakawa, T, Nakamura, M, Kubosaki, A, Hayashida, K, Kawazu, C, Murata, M, Nishiyori, H, Fukuda, S, Kawai, J, Daub, CO, Hume, DA, Suzuki, H, Orlando, V, Carninci, P, Hayashizaki, Y and Mattick, JS (2009). Tiny RNAs associated with transcription start sites in animals. Nature Genetics, 41 (5), 572-578. doi: 10.1038/ng.312

Data-driven normalization strategies for high-throughput quantitative RT-PCR

Mar, Jessica C., Kimura, Yasumasa, Schroder, Kate, Irvine, Katherine M., Hayashizaki, Yoshihide, Suzuki, Harukazu, Hume, David and Quackenbush, John (2009). Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics, 10 (1) 110, 110.1-110.10. doi: 10.1186/1471-2105-10-110

The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009). The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 (4) R40. doi: 10.1186/gb-2009-10-4-r40

FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions

Severin, Jessica, Waterhouse, Andrew M., Kawaji, Hideya, Lassmann, Timo, van Nimwegen, Erik, Balwierz, Piotr J., de Hoon, Michiel J. L., Hume, David A., Carninci, Piero, Hayashizaki, Yoshihide, Suzuki, Harukazu, Daub, Carsten O. and Forrest, Alistair R. R. (2009). FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions. Genome Biology, 10 (4) R39. doi: 10.1186/gb-2009-10-4-r39

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Auffray, Cedric, Fogg, Darin K., Narni-Mancinelli, Emilie, Senechal, Brigitte, Trouillet, Celine, Saederup, Noah, Leemput, Julia, Bigot, Karine, Campisi, Laura, Abitbol, Marc, Molina, Thierry, Charo, Israel, Hume, David A., Cumano, Ana, Lauvau, Gregoire and Geissmann, Frederic (2009). CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. Journal of Experimental Medicine, 206 (3), 595-606. doi: 10.1084/jem.20081385

TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium

Trieu, Angela, Bokil, Nilesh, Dunn, Jasmyn A., Roberts, Tara L., Xu, Damo, Liew, Foo Y., Hume, David A., Stacey, Katryn J. and Sweet, Matthew J. (2009). TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium. Immunology and Cell Biology, 87 (3), 218-225. doi: 10.1038/icb.2008.95

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009). HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 (5917), 1057-1060. doi: 10.1126/science.1169841

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009). Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 (2), 278-288. doi: 10.1189/jlb.0808497

Our evolving knowledge of the transcriptional landscape

Hume, David A. (2008). Our evolving knowledge of the transcriptional landscape. Mammalian Genome, 19 (10-12), 663-666. doi: 10.1007/s00335-008-9140-y

A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE

Faulkner, G. J., Forrest, A. R. R., Chalk, A. M., Schroder, K., Hayashizaki, Y., Carninci, P., Hume, D. A. and Grimmond, S. M. (2008). A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics, 91 (3), 281-288. doi: 10.1016/j.ygeno.2007.11.003

Macrophages as APC and the dendritic cell myth

Hume, David A. (2008). Macrophages as APC and the dendritic cell myth. Journal of Immunology, 181 (9), 5829-5835. doi: 10.4049/jimmunol.181.9.5829

Osteal macrophages: A new twist on coupling during bone dynamics

Pettit, A. R., Chang, M. K., Hume, D. A. and Raggatt, L. J. (2008). Osteal macrophages: A new twist on coupling during bone dynamics. Bone, 43 (6), 976-982. doi: 10.1016/j.bone.2008.08.128

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?

Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78

Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer

Maeda, Norihiro, Nishiyori, Hiromi , Nakamura, Mari , Kawazu, Chika, Murata, Mitsuyoshi , Sano, Hiromi, Hayashida, Kengo, Fukuda, Shiro, Tagami, Michihira, Hasegawa, Akira, Murakami, Kayoko, Schroder, Kate, Irvine, Katharine, Hume, David A., Hayashizaki, Yoshihide, Carninci, Piero and Suzuki, Harukazu (2008). Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. BioTechniques, 45 (1), 95-97. doi: 10.2144/000112814

Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry

King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008). Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 (13), 5036-5043. doi: 10.1021/ac702277q

Cortactin adopts a globular conformation and bundles actin into sheets

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200

Increased TNF expression in CD43++ murine blood monocytes

Burke, Bernard, Ahmad, Rasheedah, Staples, Karl J., Snowden, Roger, Kadioglu, Aras, Frankenberger, Marion, Hume, David A. and Ziegler-Heitbrock, Loems (2008). Increased TNF expression in CD43++ murine blood monocytes. Immunology Letters, 118 (2), 142-147. doi: 10.1016/j.imlet.2008.03.012

The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

WellsChristineA, Salvage-JonesJudithA, LiXin, HitchensKelly, ButcherSuzanne, MurrayRachaelZ, Beckhouse, Anthony G., LoYu-Lan-Sandra, ManzaneroSilvia, CobboldChristian, SchroderKate, MaBo, OrrSally, StewartLauren, LebusDaniel, SobieszczukPeter, HumeDavidA, StowJennifer, BlanchardHelen, AshmanRobertB, RRich and MHogan (2008). The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology, 180 (11), 7404-7413. doi: 10.4049/jimmunol.180.11.7404

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene

Hume, David A., Sasmono, Tedjo, Himes, S. Roy, Sharma, Sudarshana M., Bronisz, Agnieszka, Constantin, Myrna, Ostrowski, Michael C. and Ross, Ian L. (2008). The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. The Journal of Immunology, 180 (10), 6733-6742. doi: 10.4049/jimmunol.180.10.6733

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo

Chang, Ming K., Raggatt, Liza-Jane, Alexander, Kylie A., Kuliwaba, Julia S., Fazzalari, Nicola L., Schroder, Kate, Maylin, Erin R., Ripoll, Vera M, Hume, David A. and Pettit, Allison R. (2008). Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo. The Journal of Immunology, 181 (2), 1232-1244. doi: 10.4049/jimmunol.181.2.1232

Expression analysis of G Protein-coupled receptors in mouse macrophages

Lattin, Jane E., Schroder, Kate, Su, Andrew I., Walker, John R., Zhang, Jie, Wiltshire, Tim, Saijo, Kaoru, Glass, Christopher K., Hume, David A., Kellie, Stuart and Sweet, Matthew J. (2008). Expression analysis of G Protein-coupled receptors in mouse macrophages. Immunome Research, 4 (5) 5, 5. doi: 10.1186/1745-7580-4-5

Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats

Pettit, Allison R., Hume, David A. and Raggatt, Liza-Jane (2008). Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats. Bone, 42 (4), 825-825. doi: 10.1016/j.bone.2007.12.217

Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity

Lang, P., Van Harmelen, V., Kaaman, M., Parini, P., Carneheim, C., Cassady, A. I., Hume, D. A., Andersson, G. and Arner, P. (2008). Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS One, 3 (3) e1713, e1713-e1713. doi: 10.1371/journal.pone.0001713

Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice

Ovchinnikov, Dmitry A., van Zuylen, Wendy J. M., DeBats, Claire E. E., Alexander, Kylie A., Kellie, Stuart and Hume, David A. (2008). Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. Journal of Leukocyte Biology, 83 (2), 430-433. doi: 10.1189/jlb.0807585

Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB

Ripoll, V. M, Meadows, N. A., Raggatt, L. J., Chang, M. K., Pettit, A. R., Cassady, A. I. and Hume, D. A. (2008). Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Gene, 413 (1-2), 32-41. doi: 10.1016/j.gene.2008.01.014

Bring out your dead

Hume, David A. (2008). Bring out your dead. Nature Immunology, 9 (1), 12-14. doi: 10.1038/ni0108-12

Differentiation and heterogeneity in the mononuclear phagocyte system

Hume, D. A. (2008). Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunology, 1 (6), 432-441. doi: 10.1038/mi.2008.36

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

Bonifer, Constanze and Hume, David A. (2008). The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Frontiers in Bioscience-Landmark, 13 (2), 549-560. doi: 10.2741/2700

Systems biology of transcription control in macrophages

Ravasi, Timothy, Wells, Christine A. and Hume, David A. (2007). Systems biology of transcription control in macrophages. BioEssays, 29 (12), 1215-1226. doi: 10.1002/bies.20683

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

McMorran, Brendan J., Patat, Severine A. Ouvry, Carlin, John B., Grimwood, Keith, Jones, Alun, Armstrong, David S., Galati, John C., Cooper, Peter J., Byrnes, Catherine A., Francis, Paul W., Robertson, Colin F., Hume, David A., Borchers, Christoph H., Wainwright, Claire E. and Wainwright, Brandon J. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53 (10), 1782-1791. doi: 10.1373/clinchem.2007.087650

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages

Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 (6), 3495-3503. doi: 10.4049/jimmunol.179.6.3495

Erratum: Genome-wide analysis of mammalian promoter architecture and evolution (Nature Genetics (2006) 38, (626-635))

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Katayama, Shintaro, Shimokawa, Kazuro, Ponjavic, Jasmina, Semple, Colin A. M., Taylor, Martin S., Engström, Pär G., Frith, Martin C., Forrest, Alistair R. R., Alkema, Wynand B., Tan, Sin Lam, Plessy, Charles, Kodzius, Rimantas, Ravasi, Timothy, Kasukawa, Takeya, Fukuda, Shiro, Kanamori-Katayama, Mutsumi, Kitazume, Yayoi, Kawaji, Hideya, Kai, Chikatoshi, Nakamura, Mari, Konno, Hideaki, Nakano, Kenji, Mottagui-Tabar, Salim, Arner, Peter, Chesi, Alessandra, Gustincich, Stefano ... Hayashizaki, Yoshihide (2007). Erratum: Genome-wide analysis of mammalian promoter architecture and evolution (Nature Genetics (2006) 38, (626-635)). Nature Genetics, 39 (9), 1174-1174. doi: 10.1038/ng0907-1174b

G-protein-coupled receptor expression, function, and signaling in macrophages

Lattin, J., Zidar, D., Schroder, K., Kellie, S., Hume, D. and Sweet, M. (2007). G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology, 82 (1), 16-32. doi: 10.1189/jlb.0107051

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007). Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 (25), 10382-10387. doi: 10.1073/pnas.0700974104

The role of schlafen in macrophages and inflammation

van Zuijlen, WJM, Cook, AD, Ovchinnikov, DA, Kellie, S and Hume, DA (2007). The role of schlafen in macrophages and inflammation. Inflammation Research, 56, S389-S389.

Neutrophilic schizophrenia: Breaching the barrier between innate and adaptive immunity

Ferrante, Antonio, Hii, Charles and Hume, David (2007). Neutrophilic schizophrenia: Breaching the barrier between innate and adaptive immunity. Immunology and Cell Biology, 85 (4), 265-266. doi: 10.1038/sj.icb.7100036

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages

Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007). PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 (6), 1577-1590. doi: 10.1189/jlb.0107036

Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses

Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007). Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 (10), 6557-6566. doi: 10.4049/jimmunol.178.10.6557

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor

Meadows, Nicholas A., Sharma, Sudarshana M., Faulkner, Geoffrey J., Ostrowski, Michael C., Hume, David A. and Cassady, Alan I. (2007). The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. Journal of Biological Chemistry, 282 (3), 1891-1904. doi: 10.1074/jbc.M608572200

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

Rae, Fiona, Woods, Kyra, Sasmono, Tedjo, Campanale, Naomi, Taylor, Darrin, Ovchinnikov, Dmitry A., Grimmond, Sean M., Hume, David A., Ricardo, Sharon D. and Little, Melissa H. (2007). Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Developmental Biology, 308 (1), 232-246. doi: 10.1016/j.ydbio.2007.05.027

Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis

Hinshelwood, Rebecca A., Huschtscha, Lily I., Melki, John, Stirzaker, Clare, Abdipranoto, Andrea, Vissel, Bryce, Ravasi, Timothy, Wells, Christine A., Hume, David A., Reddel, Roger R. and Clark, Susan J. (2007). Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67 (24), 11517-11527. doi: 10.1158/0008-5472.CAN-07-1284

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

Bode, K. A., Schroder, K., Hume, D. A., Ravasi, T., Heeg, K., Sweet, M. J. and Dalpke, A. H. (2007). Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology, 122 (4), 596-606. doi: 10.1111/j.1365-2567.2007.02678.x

Mammalian RNA polymerase II core promoters: insights from genome-wide studies

Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y and Hume, DA (2007). Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews Genetics, 8 (6), 424-436. doi: 10.1038/nrg2026

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1

Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., Cook, A. D., Himes, S. R., Hamilton, J. A. and Hume, D. A. (2007). Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. Journal of Leukocyte Biology, 82 (1), 111-123. doi: 10.1189/jlb.1206713

S100A8/S100A9 and their association with cartilage and bone

Zreiqat, H., Howlett, C.R., Gronthos, S., Hume, D. and Geczy, C.L. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38 (5), 381-391. doi: 10.1007/s10735-007-9117-2

CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway

Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J., Hume, D. A., Stacey, K. J. and Sweet, M. J. (2006). CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. Journal of Immunology, 177 (7), 4473-4480. doi: 10.4049/jimmunol.177.7.4473

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006). A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 (11), 1921-1923. doi: 10.1096/fj.06-5848fje

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice

Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A. and Du, Hong (2006). Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice. American Journal of Pathology, 169 (3), 916-926. doi: 10.2353/ajpath.2006.051327

Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes"

Hume, David A. (2006). Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes". Journal of Immunology, 177 (4), 2035-2035. doi: 10.4049/jimmunol.177.4.2035

Transcriptional network dynamics in macrophage activation

Nilsson, Roland, Bajic, Vladimir B., Suzuki, Harukazu, di Bernardo, Diego, Bjorkegren, Johan, Katayama, Shintaro, Reid, James F., Sweet, Matthew J., Gariboldi, Manuela, Carninci, Piero, Hayashizaki, Yosihide, Hume, David A., Tegner, Jesper and Ravasi, Timothy (2006). Transcriptional network dynamics in macrophage activation. Genomics, 88 (2), 133-142. doi: 10.1016/j.ygeno.2006.03.022

Mice and men: Their promoter properties

Bajic, Vladimir B., Tan, Sin Lam, Christoffels, Alan, Schonbach, Christian, Lilpovich, Leonard, Yang, Liang, Hofmann, Oliver, Kruger, Adele, Hide, Winston, Kai, Chikatoshi, Kawai, Jun, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2006). Mice and men: Their promoter properties. Plos Genetics, 2 (4) e54, 614-626. doi: 10.1371/journal.pgen.0020054

Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs

Maeda, Norihiro, Kasukawa,Takeya, Frith, Martin, Aturaliya, Rajith N., Forrest, Alistair R. R., Ravasi,Timothy, Teasdale, Rohan D., Wells, Christine A., Hume,David A. and Hayashizaki,Yoshihide (2006). Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs. PLoS Genetics, 2 (4) e62, 498-503. doi: 10.1371/journal.pgen.0020062

Alternate transcription of the Toll-like receptor signaling cascade

Wells, C. A., Chalk, A. M., Forrest, A., Taylor, D., Waddell, N., Schroder, K., Himes, S. R., Faulkner, G., Lo, S., Kasukawa, T., Kawaji, H., Kai, C., Kawai, J., Katayama, S., Carninci, P., Hayashizaki, Y., Hume, D. A. and Grimmond, S. M. (2006). Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology, 7 (2) R10, R10.1-R10.17. doi: 10.1186/gb-2006-7-2-r10

The JNK are important for development and survival of macrophages

Himes, S. Roy, Sester, David P., Ravasi, Timothy, Cronau, Stephen L., Sasmono, Tedjo and Hume, David A. (2006). The JNK are important for development and survival of macrophages. Journal Of Immunology, 176 (4), 2219-2228. doi: 10.4049/jimmunol.176.4.2219

Innate immunity

Hume, David and Hertzog, Paul (2006). Innate immunity. Current Opinion in Immunology, 18 (1), 1-2. doi: 10.1016/j.coi.2005.11.016

An automatable screen for the rapid identification of proteins amenable to refolding

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056

Apoptotic cell removal in development and tissue homeostasis

Henson, P. M. and Hume, D. A. (2006). Apoptotic cell removal in development and tissue homeostasis. Trends In Immunology, 27 (5), 244-250. doi: 10.1016/j.it.2006.03.005

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

Brahmachary, M., Schonbach, C., Yang, L., Huang, E. L., Tan, S. L., Chowdhary, R., Krishnan, S. P. T., Lin, C. Y., Hume, D. A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y. and Bajic, V. B. (2006). Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. Bmc Bioinformatics, 7 (Supp. 5) S8, Article number S8. doi: 10.1186/1471-2105-7-S5-S8

Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase

Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006). Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62, 133-135. doi: 10.1107/S17443091060000030

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome

Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., Fukuda, S., Ru, K., Frith, M., Gongora, M., Grimmond, S., Hume, D. A., Hayashizaki, Y. and Mattick, J. S. (2006). Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Research, 16 (1), 11-19. doi: 10.1101/gr.4200206

Focusing in on structural genomics: The University of Queensland structural biology pipeline

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002

Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks

Sharma, S. M., Hu, R., Bronisz, A., Meadows, N., Lusby, T., Fletcher, B., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2006). Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks. Critical Reviews In Eukaryotic Gene Expression, 16 (3), 253-277. doi: 10.1615/critreveukargeneexpr.v16.i3.40

Genome-wide analysis of mammalian promoter architecture and evolution

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Frith, Martin C., Forrest, Alistair R. R., Ravasi, Timothy, Grimmond, Sean M., Wells, Christine A., Hume, David A. and Hayashizaki, Yoshihide (2006). Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics, 38 (6), 626-635. doi: 10.1038/ng1789

Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

Inoue, Kenji, Kobayashi, Mika, Yano, Kiichiro, Miura, Mai, Izumi, Akashi, Mataki, Chikage, Doi, Takeshi, Hamakubo, Takao, Reid, Patrick C., Hume, David A., Yoshida, Minoru, Aird, William C., Kodama, Tatsuhiko and Minami, Takashi (2006). Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression. Arteriosclerosis Thrombosis And Vascular Biology, 26 (12), 2652-2659. doi: 10.1161/01.ATV.0000247247.89787.e7

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

Aung, H. T., Schroder, K., Himes, S. R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D. A., Sweet, M. J. and Ravasi, T. (2006). LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Faseb Journal, 20 (9), 1315-1327. doi: 10.1096/fj.05-5360com

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070

Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Wu, Andy C. K., Grondahl, Lisbeth, Jack, Kevin S., Foo, Michelle X., Trau, Matt, Hume, David A. and Cassady, Alan I. (2006). Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Biomaterials, 27 (27), 4715-4725. doi: 10.1016/j.biomaterials.2006.05.010

Signal integration between IFN gamma and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J. and Hume, D. A. (2006). Signal integration between IFN gamma and TLR signalling pathways in macrophages. Immunobiology, 211 (6-8), 511-524. doi: 10.1016/j.imbio.2006.05.007

The mononuclear phagocyte system

Hume, D. A. (2006). The mononuclear phagocyte system. Current Opinion In Immunology, 18 (1), 49-53. doi: 10.1016/j.coi.2005.11.008

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

Cochrane, Anita L., Kett, Michelle M., Samuel, Chrishan S., Campanale, Naomi V., Anderson, Warwick P., Hume, David A., Little, Melissa H., Bertram, John F. and Ricardo, Sharon D. (2005). Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. Journal of The American Society of Nephrology, 16 (12), 3623-3630. doi: 10.1681/ASN.2004090771

Therapeutic targets in inflammatory disease

Hume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923

The transcriptional landscape of the mammalian genome

The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005). The transcriptional landscape of the mammalian genome. Science, 309 (5740), 1559-1563. doi: 10.1126/science.1112014

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005). The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 (3), 1399-1405. doi: 10.4049/jimmunol.175.3.1399

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013

Antisense transcription in the mammalian transcriptome

RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005). Antisense transcription in the mammalian transcriptome. Science, 309 (5740), 1564-1566. doi: 10.1126/science.1112009

Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides

Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005). Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 (2), 605-608. doi: 10.4049/jimmunol.174.2.605

Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides

Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005). Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 (6), 3569-3576. doi: 10.4049/jimmunol.175.6.3569

Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.

Ripoll, V. M., Hume, D. A. and Fontanilla, M.R. (2005). Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.. Biomedica, 25 (2), 261-270. doi: 10.7705/biomedica.v25i2.1348

Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation

Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005). Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 (2), 154-164. doi: 10.1016/j.abb.2005.05.013

Inflammation suppressor genes: please switch out all the lights

Wells, C. A., Ravasi, T. and Hume, D. A. (2005). Inflammation suppressor genes: please switch out all the lights. Journal of Leukocyte Biology, 78 (1), 9-13. doi: 10.1189/jlb.1204710

LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action

Sester, D. P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J. A., McDonald, R. C., Ripoll, V., Wells, C. A., Suzuki, H., Hayashizaki, Y., Stacey, K. J., Hume, D. A. and Sweet, M. J. (2005). LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology, 210 (2-4), 97-107. doi: 10.1016/j.imbio.2005.05.004

Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing

Raisanen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A. and Vaananen, H. K. (2005). Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing. Biochemical And Biophysical Research Communications, 331 (1), 120-126. doi: 10.1016/j.bbrc.2005.03.133

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., Reynolds, E. C., Hume, D. A., Hamilton, J. A., Geczy, C. L. and Anderson, G. P. (2005). S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 4 (1), 136-145. doi: 10.1021/pr049829t

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha

Murray, Rachael Z., Wylie, Fiona G., Khromykh, Tatiana, Hume, David A. and Stow, Jennifer L. (2005). Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha. Journal of Biological Chemistry, 280 (11), 10478-10483. doi: 10.1074/jbc.M414420200

The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages

Himes, S. R., Cronau, S., Mulford, C. and Hume, D. A. (2005). The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene, 24 (34), 5278-5286. doi: 10.1038/sj.onc.1208657

Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor

Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Sollner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., Hume, D. A. and Andreesen, R. (2005). Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of Immunology, 174 (11), 7111-7122. doi: 10.4049/jimmunol.174.11.7111

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible

Tagoh, Hiromi, Schebesta, Alexandra, Lefevre, Pascal, Wilson, Nicola, Hume, David, Busslinger, Meinrad and Bonifer, Constanze (2004). Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. The EMBO Journal, 23 (21), 4275-4285. doi: 10.1038/sj.emboj.7600421

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008

Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis

Kasukawa, T., Katayama, S., Kawaji, H., Suzuki, H., Hume, D. A. and Hayashizaki, Y. (2004). Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis. Genomics, 84 (6), 913-921. doi: 10.1016/j.ygeno.2004.08.011

Interferon-gamma: an overview of signals, mechanisms and functions

Schroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004). Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 (2), 163-189. doi: 10.1189/jlb.0603252

Probing the S100 protein family through genomic and functional analysis

Ravasi, Timothy, Hsu, Kenneth, Goyette, Jesse, Schroder, Kate, Yang, Zheng, Rahimi, Farid, Miranda, Les P., Alewood, Paul F., Hume, David A. and Geczy, Carolyn (2004). Probing the S100 protein family through genomic and functional analysis. Genomics, 84 (1), 10-22. doi: 10.1016/j.ygeno.2004.02.002

Rasputin, more promiscuous than ever: a review of G3BP

Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004). Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 (10), 1065-1077. doi: 10.1387/ijdb.041893ki

Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection

McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D. and Wainwright, B. (2003). Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infection And Immunity, 71 (10), 6035-6044. doi: 10.1128/IAI.71.10.6035-6044.2003

Genetic control of the innate immune response

Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B. J. and Hume, D. A. (2003). Genetic control of the innate immune response. BMC Immunology, 4 (Article 5) 5, 1-18. doi: 10.1186/1471-2172-4-5

A guide to the mammalian genome

Okazaki, Yasushi and Hume, David A. (2003). A guide to the mammalian genome. Genome Research, 13 (6 B), 1267-1272. doi: 10.1101/gr.1445603

Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome

Zavolan, M., Kondo, S., Schonbach, C., Adachi, J., Hume, D. A., Hayashizaki, Y., Gaasterland, T., RIKEN GER Grp and GLS Members (2003). Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Research, 13 (6B), 1290-1300. doi: 10.1101/gr.1017303

Phosphoregulators: Protein kinases and protein phosphatases of mouse

Forrest, Alistair R. R., Ravasi, Timothy, Taylor, Darrin, Huber, Thomas L., Hume, David A., RIKEN GER Group, GSL Members and Grimmond, Sean (2003). Phosphoregulators: Protein kinases and protein phosphatases of mouse. Genome Research, 13 (6B), 1443-1454. doi: 10.1101/gr.954803

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA

Stacey, Katryn J., Young, Greg R., Clark, Francis, Sester, David P., Roberts, Tara L., Naik, Shalin, Sweet, Matthew J. and Hume, David A. (2003). The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. Journal of Immunology, 170 (7), 3614-3620. doi: 10.4049/jimmunol.170.7.3614

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse

Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R. and Hume, D. A. (2003). A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 101 (3), 1155-1163. doi: 10.1182/blood-2002-02-1569

CSF-1 as a regulator of macrophage activation and immune responses

Sweet, MJ and Hume, DA (2003). CSF-1 as a regulator of macrophage activation and immune responses. Archivum Immunologiae Et Therapiae Experimentalis, 51 (3), 169-177.

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage

Wells, C. A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Faulkner, G. J., Okazaki, Y., Quackenbush, J., Hume, D. A., RIKEN GER Group,, GSL Members, and Lyons, P. A. (2003). Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Research, 13 (6B), 1360-1365. doi: 10.1101/gr.1056103

Development and evaluation of an automated annotation pipeline and cDNA annotation system

Kasukawa, T., Furuno, M., Nikaido, I., Bono, H., Hume, D. A., Bult, C., Hill, D. P., Baldarelli, R., Gough, J., Kanapin, A., Matsuda, H., Schriml, L. M., Hayashizaki, Y., Okazaki, Y. and Quackenbush, J. (2003). Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Research, 13 (6B), 1542-1551. doi: 10.1101/gr.992803

Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome

Tajul Arifin, K., Teasdale, R. D., Ravasi, T., Hume, D. A., RIKEN GER Group,, GSL Members, and Mattick, J. S. (2003). Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Reaserch, 13 (6B), 1416-1429. doi: 10.1101/gr.1015703

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection

Numata, K., Kanai, A., Saito, R., Kondo, S., Adachi, J., Wilming, L. G., Hume, D. A., RIKEN GER Group,, GSL Members,, Hayashizaki, Y. and Tomita, M. (2003). Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Research, 13 (6B), 1301-1306. doi: 10.1101/gr.1011603

Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene

Walsh, N. C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D. A. and Cassady, A. I. (2003). Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene, 307 (1-2), 111-123. doi: 10.1016/S0378-1119(03)00449-9

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome

Ravasi, T., Huber, T. L., Zavolan, M., Forrest, A. R., Gaasterland, T., Grimmond, S. M., RIKEN GER Group,, GSL Members, and Hume, D. A. (2003). Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome. Genome Research, 13 (6B), 1430-1442. doi: 10.1101/gr.949803

The mouse secretome: functional classification of the proteins secreted into the extracellular environment

Grimmond, Sean M., Miranda, Kevin C., Yuan, Zheng, Davis, Melissa J., Hume, David A., Yagi, Ken, Tominaga, Naoko, Bono, Hidemasa, Hayashizaki, Yoshihide, Okazaki, Yasushi, RIKEN GER Group,, GSL Members, and Teasdale, Rohan D. (2003). The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Research, 13 (6B), 1350-1359. doi: 10.1101/gr.983703

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Teasdale, R. D., Hume, D. A., Yuan, Zheng and The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team (2002). Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420 (6915), 563-573. doi: 10.1038/nature01266

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities

Oceandy, Delvac, McMorran, Brendan J., Smith, Stephen N., Schreiber, Rainer, Kunzelmann, Karl, Alton, Eric W. F. W., Hume, David A. and Wainwright, Brandon J. (2002). Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics, 11 (9), 1059-1067. doi: 10.1093/hmg/11.9.1059

NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells

Xie, Y., Chen, C. M., Stevenson, M. A., Hume, D. A., Auron, P. E. and Calderwood, S. K. (2002). NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochemical And Biophysical Research Communications, 291 (4), 1071-1080. doi: 10.1006/bbrc.2002.6562

Erratum: Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes (The Journal of Immunology (2002) 168 (44-50))

Ravasi, Timothy, Wells, Christine, Forrest, Alistair, Underhill., David M., Wainwright, Brandon J., Aderem, Alan, Grimmond, Sean and Hume, David A. (2002). Erratum: Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes (The Journal of Immunology (2002) 168 (44-50)). Journal of Immunology, 168 (3)

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages

Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., Hume, David A. and Liew, Foo Y. (2002). Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. Journal of Immunology, 168 (1), 392-399. doi: 10.4049/jimmunol.168.1.392

Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S. and Hume, D. A. (2002). Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes. Journal of Immunology, 168 (1), 44-50. doi: 10.4049/jimmunol.168.1.44

Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism

Wardrop, S. L., Wells, C., Ravasi, T., Hume, D. A. and Richardson, D. R. (2002). Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism. Journal of Leukocyte Biology, 71 (1), 99-106. doi: 10.1189/jlb.71.1.99

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. and Ostrowski, M. C. (2002). The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts. Journal of Leukocyte Biology, 71 (2), 295-303. doi: 10.1189/jlb.71.2.295

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter

Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. and Ostrowski, M. C. (2002). The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. Journal of Leukocyte Biology, 71 (2), 304-310. doi: 10.1189/jlb.71.2.304

The mononuclear phagocyte system revisited

Hume, David A., Ross, Ian L., Himes, S. Roy, Sasmono, R. Tedjo, Wells, Christine A. and Ravasi, Timothy (2002). The mononuclear phagocyte system revisited. Journal of Leukocyte Biology, 72 (4), 621-627. doi: 10.1189/jlb.72.4.621

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells

Tagoh, H., Himes, R., Clarke, D., Leenen, P. J. M., Riggs, A. D., Hume, D. and Bonifer, C. (2002). Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes and Development, 16 (13), 1721-1737. doi: 10.1101/gad.222002

A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression

Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, T., Oceandy, D., Clark, R., Bonifer, C. and Hume, D. A. (2001). A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. Journal of Leukocyte Biology, 70 (5), 812-820. doi: 10.1189/jlb.70.5.812

G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease

Mcmorran, B., Palmer, J., Lunn, D., Oceandy, D., Costelloe, E. O., Thomas, G., Hume, D. A. and Wainwright, B. J. (2001). G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. AJP-Lung Cellular and Molecular Physiology, 281 (3), 740-747. doi: 10.1152/ajplung.2001.281.3.L740

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation

Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2001). Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. Journal of Biological Chemistry, 276 (39), 36703-36710. doi: 10.1074/jbc.M106418200

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state

Hume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A.O., Liew, F.Y. and Aderem, A. (2001). Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunology, 2 (11) 11, 1-12. doi: 10.1186/1471-2172-2-11

Structural genomics: Protein structures for the masses?

Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001). Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 (2), 13-16.

Transcriptional regulation of c-fms gene expression

Xie, Y., Chen, C. M. and Hume, D. A. (2001). Transcriptional regulation of c-fms gene expression. Cell Biochemistry And Biophysics, 34 (1), 1-16. doi: 10.1385/CBB:34:1:001

Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene

Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A., Sester, D., Mignotte, B. and Jeannin, J. F. (2000). Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14 (15), 2393-2395. doi: 10.1096/fj.98-0509fje

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9

G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages

Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000). G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 (7), 3870-3877. doi: 10.4049/jimmunol.164.7.3870

Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction

Dwidedi, P. P., Omdahl, J. L., Kola, I., Hume, D. A. and Kay, B. K. (2000). Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction. Journal of Biological Chemistry, 275 (1), 47-55. doi: 10.1074/jbc.275.1.47

Co-operative induction of pro-inflammatory signaling by Toll-like receptors

Ozinsky, A., Smith, K. D., Hume, D. and Underhill, D. M. (2000). Co-operative induction of pro-inflammatory signaling by Toll-like receptors. Journal of Endotoxin Research, 6 (5), 393-396. doi: 10.1177/09680519000060051101

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice

Smith, James L., Schaffner, Alicia E., Hofmeister, Joseph K., Hartman, Matthew Hartman, Wei, Guo, Forsthoefel, David, Hume, David A. and Ostrowski, Michael C. (2000). Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Molecular and Cellular Biology, 20 (21), 8026-8034. doi: 10.1128/MCB.20.21.8026-8034.2000

Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene

Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A. and Sester, D. (2000). Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. The FASEB Journal, 15 (15), 2393-2395.

How do you see CG

Aderem, A. and Hume, D. A. (2000). How do you see CG. Cell, 103 (7), 993-996. doi: 10.1016/S0092-8674(00)00201-4

Identification of mammalian-like purple acid phosphatases in a wide range of plants

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.

Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000). Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 (4), 427-438. doi: 10.1089/107999000312379

Macrophage activation by immunostimulatory DNA

Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000). Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247, 41-58. doi: 10.1007/978-3-642-59672-8_3

Origins and functions of phagocytes in the embryo

Lichanska, A. M. and Hume, D. A. (2000). Origins and functions of phagocytes in the embryo. Experimental Hematology, 28 (6), 601-611. doi: 10.1016/S0301-472X(00)00157-0

Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1

Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000). Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 (8), 4165-4173. doi: 10.4049/jimmunol.165.8.4165

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

Hume, David A. (2000). Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood, 96 (7), 2323-2328. doi: 10.1182/blood.v96.7.2323.h8002323_2323_2328

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X

Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor

Fowles, L. F., Stacey, K. J., Marks, D., Hamilton, J. A. and Hume, D. A. (2000). Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochemical Journal, 347 (1), 313-320. doi: 10.1042/0264-6021:3470313

The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts

Luchin, A., Purdom, G., Murphy, K. M., Clark, M., Angel, N., Cassady, A. I., Hume, D. A. and Ostrowski, M. (2000). The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts. Journal of Bone and Mineral Research, 15 (3), 451-460. doi: 10.1359/jbmr.2000.15.3.451

Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover

Angel, N., Cahill, M. M., King, A., Ostrowski, M., Cassady, A. I. and Hume, D. A. (2000). Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover. Journal of Bone and Mineral Research, 15 (1), 103-110. doi: 10.1359/jbmr.2000.15.1.103

S100A8: Emerging functions and regulation

Passey, Robert J., Xu, Ken, Hume, David A. and Geczy, Carolyn L. (1999). S100A8: Emerging functions and regulation. Journal of Leukocyte Biology, 66 (4), 549-556. doi: 10.1002/jlb.66.4.549

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo

Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999). A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 (4), 2209-2216.

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1

Lichanska, Agnieszka M., Browne, Catherine M., Henkel, Gregory W., Murphy, Kathleen M., Ostrowski, Michael C., McKercher, Scott R., Maki, Richard A. and Hume, David A. (1999). Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1. Blood, 94 (1), 127-138.

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999). Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 (4), 279-291. doi: 10.3109/08977199909069146

Young scientists in biomedical research

Hume, DA (1999). Young scientists in biomedical research. Science, 284 (5411), 49-49. doi: 10.1126/science.284.5411.49c

Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members

Rehli, Michael, Den Elzen, Nicole, Cassady, A. Ian, Ostrowski, Michael C. and Hume, David A. (1999). Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics, 56 (1), 111-120. doi: 10.1006/geno.1998.5588

Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999). Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 (12), 6541-6550.

CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages

Kakuda, D. K., Sweet, M. J., MacLeod, C. L., Hume, D. A. and Markovich, D. (1999). CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochemical Journal, 340 (2), 549-553. doi: 10.1042/0264-6021:3400549

Crystal structure of mammalian purple acid phosphatase

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E., De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase. Structure With Folding & Design, 7 (7), 757-767. doi: 10.1016/S0969-2126(99)80100-2

Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase

Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J., Hamilton, S. E. and Martin, J. L. (1999). Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase. Acta Crystallographica Section D: Biological Crystallography, 55 (8), 1462-1464. doi: 10.1107/S0907444999006241

Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide

Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999). Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 (3), 528-534. doi: 10.1002/jlb.66.3.528

Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin

Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999). Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 (1), 172-183. doi: 10.1002/jlb.66.1.172

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors

Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. and Hume, D. A. (1999). TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Journal of Immunology, 162 (3), 1559-1565.

The actions of bacterial DNA on murine macrophages

Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999). The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 (4), 542-548. doi: 10.1002/jlb.66.4.542

Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling

Fowles, Lindsay F., Martin, Michele L., Nelsen, Lori, Stacey, Katryn J., Redd, Douglas, Clark, Ying Mei, Nagamine, Yoshikune, McMahon, Martin, Hume, David A. and Ostrowski, Michael C. (1998). Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling. Molecular and Cellular Biology, 18 (9), 5148-5156. doi: 10.1128/MCB.18.9.5148

Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific basal transcription initiation

Ross, Ian L., Yue, Xie, Ostrowski, Michael C. and Hume, David A. (1998). Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific basal transcription initiation. Journal of Biological Chemistry, 273 (12), 6662-6669. doi: 10.1074/jbc.273.12.6662

IFN-γ primes macrophage responses to bacterial DNA

Sweet, M. J., Stacey, K. J., Kakuda, D. K., Markovich, D. and Hume, D. A. (1998). IFN-γ primes macrophage responses to bacterial DNA. Journal of Interferon and Cytokine Research, 18 (4), 263-271. doi: 10.1089/jir.1998.18.263

Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophage

Sweet, M. J., Stacey, K. J., Ross, I. L., Ostrowski, M. C. and Hume, D. A. (1998). Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophage. Journal of Inflammation, 48 (2), 67-83.

Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS

Osborne, JM, den Elzen, N, Lichanska, AM, Costelloe, EO, Yamada, T, Cassady, AI and Hume, DA (1998). Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS. Journal of Leukocyte Biology, 64 (5), 692-701. doi: 10.1002/jlb.64.5.692

Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2

D'Orazio, Daniel, Besser, Daniel, Marksitzer, René, Kunz, Christina, Hume, David A., Kiefer, Birgitta and Nagamine, Yoshikuni (1997). Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene, 201 (1-2), 179-187. doi: 10.1016/S0378-1119(97)00445-9

Recombinant human and mouse purple acid phosphatases: expression and characterization

Marshall, Karen, Nash, Kevin, Haussman, George, Cassady, Ian, Hume, David, De Jersey, John and Hamilton, Susan (1997). Recombinant human and mouse purple acid phosphatases: expression and characterization. Archives of Biochemistry and Biophysics, 345 (2), 230-236. doi: 10.1006/abbi.1997.0250

Effects of CSF-1 on cholesterol accumulation and efflux by macrophages

Jessup, W, Squires, B, Kritharides, L, Hume, DA and Dean, RT (1997). Effects of CSF-1 on cholesterol accumulation and efflux by macrophages. Arteriosclerosis Thrombosis and Vascular Biology, 17 (1), 18-25. doi: 10.1161/01.ATV.17.1.18

Regulation of CSF-1 receptor expression

Hume, D. A., Yue, X., Ross, I. L., Favot, P., Lichanska, A. and Ostrowski, M. C. (1997). Regulation of CSF-1 receptor expression. Molecular Reproduction and Development, 46 (1), 46-53. doi: 10.1002/(SICI)1098-2795(199701)46:1<46::AID-MRD8>3.0.CO;2-R

Marketing for leisure and tourism - Michael Morgan

Hume, David A. (1996). Marketing for leisure and tourism - Michael Morgan. Tourism Management, 17 (8), 621-621. doi: 10.1016/S0261-5177(97)84227-6

Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1)

Yue, X., Ross, I. L., Browne, C. M., Lichanska, A., Favot, P., Ostrowski, M. C. and Hume, D. A. (1996). Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1). Immunobiology, 195 (4-5), 461-476. doi: 10.1016/S0171-2985(96)80016-7

Endotoxin signal transduction in macrophages

Sweet, M. J. and Hume, D. A. (1996). Endotoxin signal transduction in macrophages. Journal of Leukocyte Biology, 60 (1), 8-26. doi: 10.1002/jlb.60.1.8

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations

Delaney, Stephen J., Alton, Eric W.F.W., Smith, Stephen N., Lunn, Dominic P., Farley, Ray, Lovelock, Paul K., Thomson, Scott A., Hume, David A., Lamb, David, Porteous, David J., Dorin, Julia R. and Wainwright, Brandon J. (1996). Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO Journal, 15 (5), 955-963. doi: 10.1002/j.1460-2075.1996.tb00432.x

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

Yang, Beom-Seok, Hauser, Craig A., Henkel, Gregory, Colman, Michael S., Van Beveren, Charles, Stacey, Katryn J., Hume, David A., Maki, Richard A. and Ostrowski, Michael C. (1996). Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Molecular and Cellular Biology, 16 (2), 538-547. doi: 10.1128/MCB.16.2.538

Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264

Sweet, M. J. and Hume, D. A. (1996). Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264. Journal of Leukocyte Biology, 59 (2), 280-286. doi: 10.1002/jlb.59.2.280

Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1

Symons, AL, Mackay, CA, Leong, K, Hume, DA, Waters, MJ and Marks, SC (1996). Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1. Growth Factors, 13 (1-2), 1-+. doi: 10.3109/08977199609034562

Macrophages ingest and are activated by bacterial DNA

Stacey, K. J., Sweet, M. J. and Hume, D. A. (1996). Macrophages ingest and are activated by bacterial DNA. Journal of Immunology, 157 (5), 2116-2122.

Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter

Chen, C.M., Clarkson, R.W., Xie, Y., Hume, D.A. and Waters, M.J. (1995). Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter. Endocrinology, 136 (10), 4505-4516. doi: 10.1210/en.136.10.4505

Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines

Favot, P, Yue, X and Hume, DA (1995). Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines. Oncogene, 11 (7), 1371-1381.

Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor

Stacey, Katryn J., Fowles, Lindsay F., Colman, Michael S., Ostrowski, Michael C. and Hume, David A. (1995). Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Molecular and Cellular Biology, 15 (6), 3430-3441. doi: 10.1128/MCB.15.6.3430

Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling

Hume, D. A., Monkley, S. J. and Wainwright, B. J. (1995). Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling. British Journal of Haematology, 90 (4), 939-942. doi: 10.1111/j.1365-2141.1995.tb05220.x

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

Hume D.A. and Favot P. (1995). Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?. Journal of Interferon and Cytokine Research, 15 (4), 279-284. doi: 10.1089/jir.1995.15.279

RAW264 macrophages stably transfected with an HIV-1-LTR reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated with lipopolysaccharide, TNF-α or taxol

Sweet, M. J. and Hume, D. A. (1995). RAW264 macrophages stably transfected with an HIV-1-LTR reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated with lipopolysaccharide, TNF-α or taxol. Journal of Inflammation, 45 (2), 126-135.

RNA synthesis inhibition stabilises urokinase mRNA in macrophages

Stacey, Katryn J., Nagamine, Yoshikuni and Hume, David A. (1994). RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letters, 356 (2-3), 311-313. doi: 10.1016/0014-5793(94)01294-6

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes

Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A. and Ostrowski, M. C. (1994). Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. Journal of Experimental Medicine, 180 (6), 2309-2319. doi: 10.1084/jem.180.6.2309

Transcription of individual genes in eukaryotic cells occurs randomly and infrequently

Ross, Ian L., Browne, Catherine M. and Hume, David A. (1994). Transcription of individual genes in eukaryotic cells occurs randomly and infrequently. Immunology and Cell Bbiology, 72 (2), 177-185. doi: 10.1038/icb.1994.26

Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes

Ross, I. L., Dunn, T. L., Yue, X., Roy, S., Barnett, C. J. and Hume, DA (1994). Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene, 9 (1), 121-132.

The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line

Murphy, K. M., Sweet, M. J. and Hume, D. A. (1994). The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line. Journal of Leukocyte Biology, 56 (3), 294-303. doi: 10.1002/jlb.56.3.294

Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages

Murphy, Kathleen M., Sweet, Matthew J., Ross, Ian L. and Hume, David A. (1993). Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages. Journal of Virology, 67 (12), 6956-6964. doi: 10.1128/jvi.67.12.6956-6964.1993

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase

Cassady, A. Ian, King, Andrew G., Cross, Nicholas C. P. and Hume, David A. (1993). Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. Gene, 130 (2), 201-207. doi: 10.1016/0378-1119(93)90420-8

Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation

Yue, Xie, Favot, Paula, Dunn, Timothy L., Cassady, A. Ian and Hume, David A. (1993). Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Molecular and Cellular Biology, 13 (6), 3191-3201. doi: 10.1128/MCB.13.6.3191

Electroporation and DNA-dependent cell-death in murine macrophages

Stacey, Katryn J., Ross, Ian L. and Hume, David A. (1993). Electroporation and DNA-dependent cell-death in murine macrophages. Immunology and Cell Biology, 71 (2), 75-85. doi: 10.1038/icb.1993.8

Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria

Pavli, P, Hume, DA, Vandepol, E and Doe, WF (1993). Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria. Immunology, 78 (1), 132-141.

The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin

Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993). The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 (3), 392-401. doi: 10.1111/j.1365-2141.1993.tb03092.x

Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain

Le, Fei, Wilce, Peter A., Hume, David A. and Shanley, Brian C. (1992). Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain. Journal of Neurochemistry, 59 (4), 1309-1315. doi: 10.1111/j.1471-4159.1992.tb08442.x

Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice

Doyle, Anthony G., Halliday, William J., Barnett, Christopher J., Dunn, Timothy L. and Hume, David A. (1992). Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice. Infection and Immunity, 60 (4), 1465-1472. doi: 10.1128/IAI.60.4.1465-1472.1992

Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts

Warren, Hilary S., Hodder, Michelle J., Allan, William, Hume, David A. and Simeonovic, Charmaine J. (1992). Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts. Transplantation, 53 (4), 834-840. doi: 10.1097/00007890-199204000-00025

Letter to the editor

Hume, D., McGarry, M. P. and Stewart, C. (1992). Letter to the editor. Journal of Leukocyte Biology, 51 (5), 517-518. doi: 10.1002/jlb.51.5.517

Rezensionen

Lüthe, Rudolf and Hume, David (1992). Rezensionen. Deutsche Zeitschrift fur Philosophie, 40 (12), 1471-1488. doi: 10.1524/dzph.1992.40.12.1471

Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication

Todd, B., Pope, J. H., Ross, I. L. and Hume, D. A. (1992). Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication. Journal of Virological Diseases, 1, 24-33.

The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice

Hume, D. A. and Denkins, Y. (1992). The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine and Cytokine Research, 11 (2), 95-98.

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991). Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 (24), 6839-6847. doi: 10.1093/nar/19.24.6839

Interactions Among Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Ifn-Gamma Lead to Enhanced Proliferation of Murine Macrophage Progenitor Cells

Breen, FN, Hume, DA and Weidemann, MJ (1991). Interactions Among Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Ifn-Gamma Lead to Enhanced Proliferation of Murine Macrophage Progenitor Cells. Journal of Immunology, 147 (5), 1542-1547.

Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain

Le, F., Wilce, P. A., Cassady, I., Hume, D. A. and Shanley, B. C. (1991). Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. Alcohol and Alcoholism. Supplement, 1, 211-214.

The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: Actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents

Abd, A.-H.A., Savage, N.W., Halliday, W.J. and Hume, D.A. (1991). The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: Actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents. Lymphokine and Cytokine Research, 10 (1-2), 43-50.

Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain

Le, Fei, Wilce, Peter, Cassady, Ian, Hume, David and Shanley, Brain (1990). Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. Neuroscience Letters, 120 (2), 271-274. doi: 10.1016/0304-3940(90)90057-G

Isolation and Characterization of Antigen-Presenting Dendritic Cells From the Mouse Intestinal Lamina Propria

Pavli, P, Woodhams, CE, Doe, WF and Hume, DA (1990). Isolation and Characterization of Antigen-Presenting Dendritic Cells From the Mouse Intestinal Lamina Propria. Immunology, 70 (1), 40-47.

The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture

Breen, Frances N., Hume, David A. and Weidemann, Maurice J. (1990). The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture. British Journal of Haematology, 74 (2), 138-145. doi: 10.1111/j.1365-2141.1990.tb02556.x

Immunopathological Investigations During the Course of Arthritis Induced in Rats by Streptococcus-Agalactiae

Abd, Aha, Hume, DA, Halliday, WJ and Davis, Ghg (1990). Immunopathological Investigations During the Course of Arthritis Induced in Rats by Streptococcus-Agalactiae. Medical Microbiology and Immunology, 179 (1), 13-23. doi: 10.1007/BF00190146

Macrophage colony-stimulating factor

Hume D. (1990). Macrophage colony-stimulating factor. Today's Life Science, 2 (6)

Encapsulation Is Not Involved in the Activities of Recombinant Gamma-Interferon Associated with Multilamellar Phospholipid Liposomes On Murine Bone Marrow-Derived Macrophages

Hume, DA and Nayar, R (1989). Encapsulation Is Not Involved in the Activities of Recombinant Gamma-Interferon Associated with Multilamellar Phospholipid Liposomes On Murine Bone Marrow-Derived Macrophages. Lymphokine Research, 8 (4), 415-425.

The therapeutic effect of human recombinant macrophage colony stimulating factor (Csf-1) in experimental murine metastatic melanoma

Hume, D. A., Donahue, R. E. and Fidler, I. J. (1989). The therapeutic effect of human recombinant macrophage colony stimulating factor (Csf-1) in experimental murine metastatic melanoma. Lymphokine Research, 8 (1), 69-77.

Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction

Hume D.A. and Denkins Y.M. (1989). Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction. Immunology and Cell Biology, 67 (4), 243-249. doi: 10.1038/icb.1989.37

The Effect of Human Recombinant Macrophage Colony-Stimulating Factor (Csf-1) On the Murine Mononuclear Phagocyte System Invivo

Hume, DA, Pavli, P, Donahue, RE and Fidler, IJ (1988). The Effect of Human Recombinant Macrophage Colony-Stimulating Factor (Csf-1) On the Murine Mononuclear Phagocyte System Invivo. Journal of Immunology, 141 (10), 3405-3409.

Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier

Schackert, Gabriele, Simmons, Rex D., Buzbee, Thomas M., Hume, David A. and Fidler, Isaiah J. (1988). Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier. Journal of the National Cancer Institute, 80 (13), 1027-1034. doi: 10.1093/jnci/80.13.1027

Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice

Russell, Pamela J., Philips, Jeanette, Allan, William and Hume, David A. (1988). Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice. Journal of Leukocyte Biology, 43 (4), 335-342. doi: 10.1002/jlb.43.4.335

Direct demonstration of production of transforming growth factor activity by embryonic chick tissue

McLachlan, J. C., Macintyre, J., Hume, D. D. and Smith, J. (1988). Direct demonstration of production of transforming growth factor activity by embryonic chick tissue. Experientia, 44 (4), 351-352. doi: 10.1007/BF01961280

Role of Ia-Positive Leukocytes and F4/80-Positive Macrophages in the Immunogenicity of Fetal Mouse Proislets and Fetal Pancreas

Simeonovic, CJ, Hodder, MJ and Hume, DA (1988). Role of Ia-Positive Leukocytes and F4/80-Positive Macrophages in the Immunogenicity of Fetal Mouse Proislets and Fetal Pancreas. Transplantation Proceedings, 20 (1), 68-71.

A microwell assay for anchorage independent cell growth

Macintyre, John, Hume, David D., Smith, Janet and McLachlan, John C. (1988). A microwell assay for anchorage independent cell growth. Tissue and Cell, 20 (3), 331-338. doi: 10.1016/0040-8166(88)90068-7

Immunohistochemical characterization of macrophages in human-liver and gastrointestinal tract - expression of Cd4, Hla-Dr, Okm1, and the mature macrophage marker 25F9 in normal and diseased tissue

Hume, D. A., Allan, W., Hogan, P. G. and Doe, W. F. (1987). Immunohistochemical characterization of macrophages in human-liver and gastrointestinal tract - expression of Cd4, Hla-Dr, Okm1, and the mature macrophage marker 25F9 in normal and diseased tissue. Journal of Leukocyte Biology, 42 (5), 474-484. doi: 10.1002/jlb.42.5.474

Growth-regulation in murine bone marrow-derived macrophages - effects of contaminating endotoxin in commercial Gm-Csf and interleukin-4

Hume, D. A. (1987). Growth-regulation in murine bone marrow-derived macrophages - effects of contaminating endotoxin in commercial Gm-Csf and interleukin-4. Lymphokine Research, 6 (4), 357-359.

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin

Müllbacher, A., Hume, D., Braithwaite, A. W., Waring, P. and Eichner, R. D. (1987). Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin. Proceedings of the National Academy of Sciences of the United States of America, 84 (11), 3822-3825. doi: 10.1073/pnas.84.11.3822

Regulation of proliferation of bone marrow-derived macrophages

Hume, D. A, Allan, W., Fabrus, B., Weidemann, M. J., Hapel, A. J. and Bartelmez, S. (1987). Regulation of proliferation of bone marrow-derived macrophages. Lymphokine Research, 6 (2), 127-139.

Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells

Warren, HS, Simeonovic, CJ, Allan, W and Hume, DA (1987). Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells. Transplantation Proceedings, 19 (1), 213-213.

Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus

Dixon, J. E., Allan, J. E., Doherty, P. C. and Hume, D. A. (1986). Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus. Journal of Leukocyte Biology, 40 (5), 617-628.

Localization and function of tissue macrophages

Gordon, Siamon, Crocker, Paul R., Morris, Lynn, Lee, Szu Hee, Perry, V. Hugh and Hume, David A. (1986). Localization and function of tissue macrophages. Ciba Foundation Symposia, 118, 54-67. doi: 10.1002/9780470720998.ch5

Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens

Hume, D. A. (1985). Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens. Immunobiology, 170 (5), 381-389. doi: 10.1016/S0171-2985(85)80062-0

The biology of macrophages

Hume, D. A. (1985). The biology of macrophages. Science progress, 69 (276), 485-494.

Preparation and characterization of human-bone marrow-derived macrophages

Hume, D. A., Allan, W., Golder, J., Stephens, R. W., Doe, W. F. and Warren, H. S. (1985). Preparation and characterization of human-bone marrow-derived macrophages. Journal of Leukocyte Biology, 38 (4), 541-552. doi: 10.1002/jlb.38.4.541

Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines

Hume, David A., Summers, Kim M., Cohen, Donna R. and Allan, William (1985). Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines. FEBS Letters, 180 (2), 271-274. doi: 10.1016/0014-5793(85)81084-X

Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors

Hapel, A. J., Osborne, J. M., Fung, M. C., Young, I. G., Allan, W. and Hume, D. A. (1985). Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors. Journal of Immunology, 134 (4), 2492-2497.

Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines

Summers, KM and Hume, DA (1985). Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines. Lymphokine Research, 4 (3), 229-235.

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, V. H., Hume, D. A. and Gordon, S. (1985). Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience, 15 (2), 313-326. doi: 10.1016/0306-4522(85)90215-5

Minactivin Expression in Human Monocyte and Macrophage Populations

Stephens, RW, Golder, JP, Fayle, Drh, Hume, DA, Hapel, AJ, Allan, W, Fordham, CJ and Doe, WF (1985). Minactivin Expression in Human Monocyte and Macrophage Populations. Blood, 66 (2), 333-337.

Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice

Russell, P. J., Cahill, J., Cameron, F. and Hume, D. (1985). Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. Journal of Leukocyte Biology, 38 (2), 241-254. doi: 10.1002/jlb.38.2.241

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia

Hume, David A., Perry, V. Hugh and Gordon, Siamon (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anatomical Record, 210 (3), 503-512. doi: 10.1002/ar.1092100311

The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E

Hume, David A. and Gordon, Siamon (1984). The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E. Experimental Cell Research, 150 (2), 347-355. doi: 10.1016/0014-4827(84)90578-0

Different colon-stimulating factors are detected by the interleukin-3 dependent cell-lines Fdc-Pl and 32D Cl-23

Hapel, A. J., Warren, H. S. and Hume, D. A. (1984). Different colon-stimulating factors are detected by the interleukin-3 dependent cell-lines Fdc-Pl and 32D Cl-23. Blood, 64 (4), 786-790.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of bone and associated connective tissue

Hume, D. A., Loutit, J. F. and Gordon, S. (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of bone and associated connective tissue. Journal of Cell Science, VOL. 66, 189-194.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of endocrine organs

Hume, D. A., Halpin, D., Charlton, H. and Gordon, S. (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of endocrine organs. Proceedings of the National Academy of Sciences of the United States of America, 81 (13 I), 4174-4177. doi: 10.1073/pnas.81.13.4174

Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: the roles of CSF‐1, serum, Ca2+, and adherence

Hume, David A. and Gordon, Siamon (1983). Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: the roles of CSF‐1, serum, Ca2+, and adherence. Journal of Cellular Physiology, 117 (2), 189-194. doi: 10.1002/jcp.1041170209

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs

Hume, David A., Robinson, Anne P., Macpherson, Gordon G. and Gordon, Siamon (1983). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. Journal of Experimental Medicine, 158 (5), 1522-1536. doi: 10.1084/jem.158.5.1522

The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages: an electron paramagnetic resonance study of the response to phorbol myristate acetate

Hume, David A., Gordon, Siamon, Thornalley, Paul J. and Bannister, Joe V. (1983). The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages: an electron paramagnetic resonance study of the response to phorbol myristate acetate. Biochimica Et Biophysica Acta, 763 (3), 245-250. doi: 10.1016/0167-4889(83)90131-3

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers

Hume, D. A., Perry, V. H. and Gordon, S. (1983). Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. Journal of Cell Biology, 97 (1), 253-257. doi: 10.1083/jcb.97.1.253

Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex

Hume, David A. and Gordon, Siamon (1983). Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. Journal of Experimental Medicine, 157 (5), 1704-1709. doi: 10.1084/jem.157.5.1704

Urinary hormone levels: a population study of associations between steroid and catecholamine excretion rates

Summers, K. M., Harrison, G. A., Hume, D. A. and Palmer, C. D. (1983). Urinary hormone levels: a population study of associations between steroid and catecholamine excretion rates. Annals of Human Biology, 10 (2), 99-110. doi: 10.1080/03014468300006241

Regulation of Bone-Marrow Macrophage Proliferation

Hume, DA and Gordon, S (1982). Regulation of Bone-Marrow Macrophage Proliferation. Advances in Experimental Medicine and Biology, 155, 261-266.

Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis

Hume, D. A., Wrogemann, K., Ferber, E., Kolbuchbraddon, M. E., Taylor, R. M., Fischer, H. and Weidemann, M. J. (1981). Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis. Biochemical Journal, 198 (3), 661-667. doi: 10.1042/bj1980661

Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

Hume, David A., Thornton, Mary R., Weidemann, Maurice J. and Speth, Volker (1979). Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli. Journal of Cellular Physiology, 101 (3), 523-528. doi: 10.1002/jcp.1041010318

Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport

Hume, DA, Weidemann, MJ and Ferber, E (1979). Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport. Journal of the National Cancer Institute, 62 (5), 1243-1246.

Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport

Hume, D. A., Weidemann, M. J. and Ferber, E. (1979). Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport. Journal of the National Cancer Institute, 62 (5), 1243-1249. doi: 10.1093/jnci/62.5.1243

Role and Regulation of Glucose-Metabolism in Proliferating Cells

Hume, DA and Weidemann, MJ (1979). Role and Regulation of Glucose-Metabolism in Proliferating Cells. Journal of the National Cancer Institute, 62 (1), 3-3.

Role and regulation of glucose metabolism in proliferating cells

Hume, D. A. and Weidemann, M. J. (1979). Role and regulation of glucose metabolism in proliferating cells. Journal of the National Cancer Institute, 62 (1), 3-8. doi: 10.1093/jnci/62.1.3

Aerobic glycolysis and lymphocyte transformation

Hume, David A., Radik, Judith L., Ferber, Ernst and Weidemann, Maurice J. (1978). Aerobic glycolysis and lymphocyte transformation. Biochemical Journal, 174 (3), 703-709. doi: 10.1042/bj1740703

On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli

Hume, David A. and Weidemann, Maurice J. (1978). On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli. Journal of Cellular Physiology, 96 (3), 303-308. doi: 10.1002/jcp.1040960305

Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport

Hume, D. A., Hansen, K., Weidemann, M. J. and Ferber, E. (1978). Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport. Nature, 272 (5651), 359-359. doi: 10.1038/272359a0

Effect of Nh4 and Ca2+ on gluconeogenesis from lactate by isolated rat hepatocytes

Hume, D. A. and Weidemann, M. J. (1978). Effect of Nh4 and Ca2+ on gluconeogenesis from lactate by isolated rat hepatocytes. Hormone and Metabolic Research, 10 (5), 449-450. doi: 10.1055/s-0028-1095840

The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens

Hume, D. A., Vijayakumar, E. K., Schweinberger, F., Russell, L. M. and Weidemann, M. J. (1978). The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens. Biochemical Journal, 174 (3), 711-716. doi: 10.1042/bj1740711

Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A: temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide

Yasmeen, Dilruba, Laird, Alan J., Hume, David A. and Weidemann, Maurice J. (1977). Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A: temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide. Biochimica Et Biophysica Acta, 500 (1), 89-102. doi: 10.1016/0304-4165(77)90049-6

Hormonal regulation of gluconeogenesis in isolated rat hepatocytes: An undergraduate experiment

hume, David A. and weidemann, Maurice J. (1976). Hormonal regulation of gluconeogenesis in isolated rat hepatocytes: An undergraduate experiment. Biochemical Education, 4 (1), 13-14. doi: 10.1016/0307-4412(76)90013-3

Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease

Whiley, P., Summers, K., Pavli, P., Hume, D. and O'Brien, C. (2023). Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease. HOBOKEN: WILEY.

Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity

Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.

3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice

Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy, Millard, Susan, Batoon, Lena, Sandrock, Cheyenne, Levesque, Jean-Pierre, Hume, David, Raggatt, Liza and Pettit, Allison (2020). 3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, New York, NY USA, 20-23 August 2020. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.exphem.2020.09.105

Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice

Irvine, Katharine, Genz, Berit, Clouston, Andrew D. and Hume, David (2018). Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco, CA USA, 9-13 November 2018. Hoboken, NJ USA: Wiley.

Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation

Pettit, Allison, Kaur, Simranpreet, Raggatt, Liza, Millard, Susan, Wu, Andy, Batoon, Lena, Jacobsen, Rebecca, Winkler, Ingrid, MacDonald, Kelli, Perkins, Andrew, Hume, David and Levesque, Jean-Pierre (2018). Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation. 47th Annual Scientific Meeting of the International Society for Experimental Hematology, Los Angeles, CA, United States, 23-26 August 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2018.06.117

Evolution of cell death responses to cytosolic DNA

Vitak, N., Johnson, K. N., Hume, D. A., Sester, D. P. and Stacey, K. J. (2016). Evolution of cell death responses to cytosolic DNA. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation

Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049

Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation

Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages

Kaur, Simranpreet, Raggatt, Liza J., Jacobsen, Rebecca, Millard, Susan, Barbier, Valerie, Nowlan, Bianca, Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean P. and Pettit, Allison R. (2015). Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, Japan, 17-19 September 2015. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2015.06.157

Cross species reactivity of Interleukin 34 (IL-34)

Gow, D. J., Garceau, V., Sester, D. and Hume, D. A. (2012). Cross species reactivity of Interleukin 34 (IL-34). European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

The production of porcine anti-CSF-1R antibodies: reagents to evaluate the effects of CSF-1 on postnatal growth

Gow, D. J., Garceau, V., Moffat, L., Kapetanovic, R., Sester, D. and Hume, D. A. (2012). The production of porcine anti-CSF-1R antibodies: reagents to evaluate the effects of CSF-1 on postnatal growth. European Congress of Immunology, Glasgow Scotland, 5-8 September 2012. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

Gene targeting of the rat Csf1r locus using homologous recombination in ES cells

Upton, Kyle R., Pridans, Clare, Meek, Stephen, Sutherland, Linda, Whitelaw, Bruce, Burdon, Tom and Hume, David (2011). Gene targeting of the rat Csf1r locus using homologous recombination in ES cells. 10th Transgenic Technology Meeting (TT2011), Florida, United States, 24-26 October 2011. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s11248-011-9540-8

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

Forrest, A. R. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., de Hoon, M. J. L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. ELSEVIER SCI LTD. doi: 10.1016/j.diff.2010.09.048

Docosahexaenoic acid (22:6n-3) protects from early retinal degeneration and attenuates microglial activation

Ebert, Stefanie, Weigelt, Karin, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009). Docosahexaenoic acid (22:6n-3) protects from early retinal degeneration and attenuates microglial activation. 50th International Conference on Bioscience of Lipids, Regenburg Germany, Sep 01-05, 2009. ELSEVIER IRELAND LTD. doi: 10.1016/j.chemphyslip.2009.06.022

Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing

Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, 11-15 September, 2009. United States: American Society for Bone and Mineral Research.

Osteomacs are critical for optimal intramembranous bone formation in a tibial defect model of bone healing

Alexander, K. A., Raggatt, L. J., Chang, M. K., Maylin, E. R., Muller, R., Kohler, T., Wu, A. C. K., Hume, D. A. and Pettit, A. R. (2009). Osteomacs are critical for optimal intramembranous bone formation in a tibial defect model of bone healing. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, NSW, Australia, 21-25 March 2009. United States: Elsevier. doi: 10.1016/j.bone.2009.01.076

Osteomacs: osteoclast precursors during inflammatory bone disease but regulators of physiologic bone remodelling

Raggatt, L. J., Chang, M. K., Alexander, K. A., Maylin, E. R., Walsh, N. C., Gravallese, E. M., Hume, D. A. and Pettit, A. R. (2009). Osteomacs: osteoclast precursors during inflammatory bone disease but regulators of physiologic bone remodelling. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, Australia, 21-25 March, 2009. New York: Elsevier Science. doi: 10.1016/j.bone.2009.01.300

The identification of novel CSF-1 target genes in human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, Oct 12-16, 2008. LONDON: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2008.07.078

Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth

Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, Sharon D. (2008). Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth. HOBOKEN: WILEY-BLACKWELL.

Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation

Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, NY, U.S.A.: Springer New York. doi: 10.1007/s00223-008-9118-5

Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization

Alexander, K. A., Chang, M. K., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoli, V. M. and Schroder, K. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization. 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, USA: Springer. doi: 10.1007/s00223-008-9118-5

Discussion

Mackay, Charles, Cyster, Jason, Goodnow, Christopher C., Lam, Kong-Peng, Vinuesa, Carola, Malissen, Bernard, Gros, Philippe, Turner, Stephen, Kaufman, Jim and Hume, David (2007). Discussion.

Discussion

Casanova, Jean-Laurent, Britton, Warwick J., Gros, Philippe, Morahan, Grant, Hume, David, Cyster, Jason, Goodnow, Christopher C., Turner, Stephen and Cook, Matthew (2007). Discussion.

Discussion

Morahan, Grant, Maizels, Rick M., Malissen, Bernard, Cyster, Jason, Turner, Stephen, Vinuesa, Carola, Britton, Warwick J., Hume, David, Lam, Kong-Peng and Cook, Matthew (2007). Discussion.

Discussion

Goodnow, Christopher C., Casanova, Jean-Laurent, Wakeland, Edward K., Morahan, Grant, Young, Douglas, Britton, Warwick J., Hume, David, Gros, Philippe, Kaufman, Jim, Maizels, Rick M. and Karupiah, Gunasegaran (2007). Discussion.

Discussion

Casanova, Jean-Laurent, Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Gros, Philippe, Hume, David, Lam, Kong-Peng, Malissen, Bernard, Vinuesa, Carola and Wakeland, Edward K. (2007). Discussion.

Discussion

Alexander, Warren S., Gros, Philippe, Hume, David, Schönbach, Christian and Vinuesa, Carola (2007). Discussion.

Discussion

Wakeland, Edward K., Morahan, Grant, Hume, David, Foote, Simon, Goodnow, Christopher C., Fortin, Anny and Gros, Philippe (2007). Discussion.

Discussion

Casanova, Jean-Laurent, Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Hume, David, Lam, Kong-Peng, Mackay, Charles, Maizels, Rick M. and Malissen, Bernard (2007). Discussion.

Discussion

Britton, Warwick J., Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Karupiah, Gunasegaran, Mackay, Charles, Morahan, Grant, Turner, Stephen and Young, Douglas (2007). Discussion.

Discussion

Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Karupiah, Gunasegaran, Maizels, Rick M., Scalzo, Anthony, Turner, Stephen and Wakeland, Edward K. (2007). Discussion.

Discussion

Cyster, Jason, Goodnow, Christopher C., Hume, David, Karupiah, Gunasegaran, Lam, Kong-Peng, Mackay, Charles, Morahan, Grant, Scalzo, Anthony, Stacker, Steven, Vinuesa, Carola and Wakeland, Edward K. (2007). Discussion.

Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice

Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, S. D. (2007). Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice. HOBOKEN: WILEY-BLACKWELL.

Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model

Ricardo, S. D., Alikhan, M. A., Campanale, N. V., Hume, D. A. and Little, M. H. (2007). Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model. HOBOKEN: WILEY-BLACKWELL.

Discussion

Belz, Gabrielle, Britton, Warwick J., Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Maizels, Rick M. and Turner, Stephen (2007). Discussion. Symposium on Cortical development: genes and genetic abnormalities, London, United Kingdom, 6–8 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

Discussion

Alexander, Warren S., Belz, Gabrielle, Britton, Warwick J., Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Hume, David, Kaufman, Jim, Mackay, Charles, Stacker, Steven and Turner, Stephen (2007). Discussion. Symposium on Cortical development: genes and genetic abnormalities, London, United Kingdom, 6–8 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

General discussion I

Goodnow C.C., Maizels R.M., Hume D., Kaufman J., Schonbach C., Gros P. and Britton W.J. (2007). General discussion I.

Osteal Macrophages: Novel regulators of Bone Formation

Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, 16th -19th September, 2007. Washington, D.C., United States: American Society for Bone and Mineral Research.

Osteal macrophages: Novel regulators of bone formation

Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, United States, 16-19 September 2007.

The Jun N-terminal kinases are important for the survival and development of macrophages

Sester, D. P., Hines, S. R., Ravasi, T., Cronau, S. L., Sasmono, T. and Hume, D. A. (2007). The Jun N-terminal kinases are important for the survival and development of macrophages. Annual Congress of the British Society of Immunology, Glasgow, Scotland, 20-23 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

The endosteal bone niche contains macrophages that regulate osteoblast function

Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, 24-29 June 2007. New York: Elsevier Science. doi: 10.1016/j.bone.2007.04.166

Transcriptional regulatory networks in macrophages

Hume D.A., Wells C.A. and Ravasi T. (2007). Transcriptional regulatory networks in macrophages.

Structure and function of mammalian fibrillin genes

Summers, K and Hume, D A (2006). Structure and function of mammalian fibrillin genes. 11th International Congress of Human Genetics, Brisbane, 6-10 Aug, 2006.

T cells are the source of GM-CSF required for collagen-induced arthritis induction.

Cook, Andrew D., Tumer, Amanda L., Braine, Emma L., Hume, David A. and Hamilton, John A. (2006). T cells are the source of GM-CSF required for collagen-induced arthritis induction.. 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Washington Dc, Nov 10-15, 2006. WILEY-LISS.

The use of transgenes to study macrophage differentiation and function

Hume, D. A. (2006). The use of transgenes to study macrophage differentiation and function. 7th Transgenic Technology Meeting (TT2007), St Lucia, Brisbane, Australia, 12-14 February 2007. Amsterdam, The Netherlands: Springer Netherlands. doi: 10.1007/s11248-006-9047-x

A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. BASEL: BIRKHAUSER VERLAG AG.

PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages

Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. BASEL: BIRKHAUSER VERLAG AG.

Beta-arrestin expression and function in macrophages

Lattin, Jane E., Blomberg, Lovisa M., Daly, Norelle L., Craik, David J., Robinson, Jodie A., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2005). Beta-arrestin expression and function in macrophages. 7th World Congress on Inflammation: Inflammation 2005: Inflammation, the Key to much pathology, Melbourne, Australia, 20 - 24 August 2005. Basel, Switzerland: Birkhaeuser.

Blockade of CSF-1 action enhances CpG DNA responses in vivo

Trieu, Angela, Cronau, Steve, Roberts, Tara, Lottin, Jane, Vlahos, Ross, Stacey, Katryn J., Hume, David A. and Sweet, Matthew J. (2005). Blockade of CSF-1 action enhances CpG DNA responses in vivo. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.

Investigation into the role of protein tyrosine phosphatase DEP-1 in macrophage function

Dave, R., Wilson, T., Cook, A., Vlahos, R., Hume, D. and Kellie, S. (2005). Investigation into the role of protein tyrosine phosphatase DEP-1 in macrophage function. 38th Annual Meeting of the Society-for-Leukocyte-Biology, Oxford, United Kingdom, 21-24 September 2005. BETHESDA: FEDERATION AMER SOC EXP BIOL.

Novel macrophage-restricted gene involved in inflammation

Ripoll, Vera M., Ravasi, Timothy and Hume, David A. (2005). Novel macrophage-restricted gene involved in inflammation. BASEL: BIRKHAUSER VERLAG AG.

Purified splenic B-cells do not respond to E. coli DNA

Roberts, Tara L., Dann, Jasmyn A., Sweet, Matthew J., Hume, David A., Lenert, Petar and Stacey, Katryn J. (2005). Purified splenic B-cells do not respond to E. coli DNA. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.

Regulation and function of toll-like receptor 9 in macrophages

Sweet, Matthew J., Schroder, Kate, Sester, David P., Trieu, Angela, Rehli, Michael, Risvanathan, Kumar, Stacey, Katryn J. and Hume, David A. (2005). Regulation and function of toll-like receptor 9 in macrophages. 7th World Congress on Inflammation, Melbourne, VIC Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.

Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS

Hume, David A., Ravasi, Timothy and Wells, Christine (2004). Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS. 1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), Budapest, Hungary, 3-7 October 2004. Malden, MA, United States: Wiley-Blackwell. doi: 10.1111/j.1399-0039.2004.00315.x

Novel genes regulated by microphthalmia transcription factor in macrophages and osteoclasts

Meadows, N. A., Faulkner, G., Wells, C., Ravasi, T., Hume, D., Sankar, U., Hu, R., Ostrowski, M. and Cassady, A. (2004). Novel genes regulated by microphthalmia transcription factor in macrophages and osteoclasts. 26th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Seattle, WA, United States, 1-5 October 2004. Malden, MA, United States: Wiley-Blackwell. doi: 10.1002/jbmr.5650191306

Regulation of the murine TRACP gene promoter

Cassady, A. I., Luchin, A., Ostrowski, M. C. and Hume, David A. (2003). Regulation of the murine TRACP gene promoter. Washington: American Society for Bone and Mineral Research. doi: 10.1359/jbmr.2003.18.10.1901

Clues to interaction between CSF-1 and CSF-1R from specificity and structure

Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. Australian Society of Immunologists Meeting, Brisbane, 1-5 December, 2002.

Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.

Saleh, H, Walsh, N, Ravasi, T, Wells, C, Okazaki, Y, Carninci, P, Hayashizaki, Y, Hume, DA and Cassady, AI (2002). Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.. 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, San Antonio Texas, Sep 20-24, 2002. WASHINGTON: AMER SOC BONE & MINERAL RES.

Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer

Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. International Conference on Structural Genomics, Berlin, 10-13 October, 2002.

Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, 29 September -3 October, 2002.

Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. Australian Society for Immunology Meeting, Brisbane, 1-5 December, 2002.

Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides

Pickering, D., Hume, D. A. and Young, P. R. (2001). Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.

Multiple promoters regulate differential expression of murine tartrate resistant acid phosphatase (TRAP).

Walsh, NC, Hume, DA and Cassady, AI (2001). Multiple promoters regulate differential expression of murine tartrate resistant acid phosphatase (TRAP).. WASHINGTON: AMER SOC BONE & MINERAL RES.

Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.

Cassady, AI, Merson, T, Suchting, S, Hong, TW and Hume, DA (2000). Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.. AMER SOC BONE & MINERAL RES.

Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.

Luchin, AI, Cassady, AI, Hume, DA and Ostrowski, MC (2000). Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.. AMER SOC CELL BIOLOGY.

Replication protein A binds preferentially to immunostimulatory oligonucleotides.

Stacey, K. J., Sester, D. P., Murphy, K. M., Sweet, M. J. and Hume, D. A. (2000). Replication protein A binds preferentially to immunostimulatory oligonucleotides.. -, -, -. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages

Himes, S. R., Goonetilleke, N. P. and Hume, D. A. (1999). An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, 22-26 September, 1999. Bethesda, Maryland: Society for Leukocyte Biology.

Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Crystallisation of a mammalian purple acid phosphatase

Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., 7-11 February, 1999. Lorne: Lorne Aust..

ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice

Ostrowski, M., Erbe, L. S., Hume, D. A. and Smith, J. L. (1999). ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Immunostimulatory DNA promotes factor independent survival of macrophages

Sester, D. P., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). Immunostimulatory DNA promotes factor independent survival of macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Australian Society for Biochemistry & Molecular Biology.

Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse

Walsh, N., Angel, N., Williams, E. A., Cassady, A. I. and Hume, D. A. (1999). Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Post-Golgi trafficking of TNF-a in macrophages

Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology In..

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Cassady, A. I., Suchting, S. J., Angel, N., Merson, T. D. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. 21st Annual Meeting of the ASBMR, St Louis, USA, 30 Sept - 4 Oct, 1999. North Carolina, USA: American Society for Bone and Mineral Res..

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Suchting, S. J., Merson, T. D., Angel, N., Cassady, A. I. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. ComBio 99, Conrad Jupiters, Gold Coast, 27th - 30th September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

Cassady, A. I., Walsh, N., Angel, N., Cahill, M. M., Forwood, M. R., Ostrowski, M. and Hume, D. A. (1999). Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. 9th Annual Scientific Meeting ANZBMS, Cairns, 30 June - 2 July, 1999. Sydney: ANZBMS.

Activation of macrophages by bacterial DNA

Stacey, K. J., Sweet, M. and Hume, D. A. (1996). Activation of macrophages by bacterial DNA. -, -, -. Oxford, United Kingdom: John Wiley & Sons .

Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1)

Yue, Xie, Ross, Ian L., Browne, Catherine M., Lichanska, Agnieszka, Favot, Paula, Ostrowski, Michael C. and Hume, David A. (1996). Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1). Elsevier GmbH. doi: 10.1016/S0171-2985(96)80016-7

Molecular-Biology of Macrophage Differentiation

Hume, DA (1993). Molecular-Biology of Macrophage Differentiation. FEDERATION AMER SOC EXP BIOL.

Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester

Stacey, K. J., Fowles, L. F., Coleman, M. S., Ostrowski, M. and Hume, D. A. (1993). Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester. -, -, -. United Kingdom: John Wiley & Sons.

Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression

Favot, P, Fidler, IJ and Hume, DA (1993). Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression. FEDERATION AMER SOC EXP BIOL.

Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine

Pavli, P, Doe, WF and Hume, DA (1988). Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine. W B SAUNDERS CO.

Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages

Pavli, P, Doe, WF and Hume, DA (1987). Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages. W B SAUNDERS CO.

Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection

Dixon, JE, Allan, JE, Ceredig, R, Hume, DA and Doherty, PC (1986). Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection. ADIS PRESS AUSTRALASIA P/L.

Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1986). Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9. W B SAUNDERS CO.

The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1985). The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract. ADIS PRESS AUSTRALASIA P/L.

Assays for Interleukin-3 (Multi-Csf) Are Not Specific

Hapel, AJ, Warren, HS, Hume, DA, Allan, W and Osborne, JM (1984). Assays for Interleukin-3 (Multi-Csf) Are Not Specific. MARY ANN LIEBERT INC PUBL.

Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues

Hume, DA and Gordon, S (1983). Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues. PROC AUST BIOCHEMICAL SOC.

Effect of Sulfhydryl Blockage On Stimulation of Thymocyte Glucose-Transport by Concanavalin-A and Ionophore-A23187

Hume, DA and Weidemann, MJ (1977). Effect of Sulfhydryl Blockage On Stimulation of Thymocyte Glucose-Transport by Concanavalin-A and Ionophore-A23187. PROC AUST BIOCHEMICAL SOC.

Mitogenic Stimulation of Thymocyte Glucose-Transport Alters Sensitivity of Glucose Carrier to N-Ethylmaleimide and Phloretin

Hume, DA and Weidemann, MJ (1977). Mitogenic Stimulation of Thymocyte Glucose-Transport Alters Sensitivity of Glucose Carrier to N-Ethylmaleimide and Phloretin. WALTER DE GRUYTER & CO.

CSF1R_FRed_SupplementaryVideos

Irvine, Katharine, Hume, David and Sehgal, Anuj (2020). CSF1R_FRed_SupplementaryVideos. The University of Queensland. (Dataset) doi: 10.14264/8c6d4ba