The University of Queensland

The impact of CAGE data on understanding macrophage transcriptional biology

Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. In Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription (pp. 227-243) : Pan Stanford Publishing Pte. Ltd.. doi:10.4032/9789814241359

A general target selection method for crystallographic proteomics

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. In Kobe, B., Guss, M. and Huber, T.L. (Ed.), Structural Proteomics: High-Throughput Methods 1st ed. (pp. 27-35) Totowa, NJ, USA: Humana Press.

A medium or high throughput protein refolding assay

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. In Bostjan Kobe, Mitchell Guss and Thomas Huber (Ed.), Structural Proteomics: High throughput Methods (pp. 269-275) USA: Humana Press.

Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. In B. Kobe, M. Guss and T. L. Huber (Ed.), Structural proteomics: High-throughput methods (pp. 577-587) Totowa, N.J.: Humana Press.

Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. In Bostjan Kobe, Mitchell Guss and Thomas L. Huber (Ed.), Structural Proteomics: High Throughput Methods 1 ed. (pp. 459-474) Totowa, NJ, USA: Humana Press.

Noncoding RNA's in mammals

Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. In Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam (Ed.), Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics (pp. xx-xx) USA: John Wiley & Sons, Inc.. doi:10.1002/047001153X.g203204

The Biology of Macrophages

Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. In Kaufmann, SE.; Medzhitov, R.; Gordon and S. (Ed.), The Innate Immune Response to Infection (pp. 71-94) Washington, DC, USA: ASM Press.

Growth and differentiation of murine macrophages

Hume, D. A., Stacey, K. J., Cassady, A. ., Browne, C. M., Sweet, M. J. and Bertoncello, I. (1996). Growth and differentiation of murine macrophages. In Handbook of experimental immunology (pp. 160.1-160.10) Boston: Wiley-Blackwell.

The regulation of urokinase plasminogen activator gene expression in macrophages

Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. In van Furth, R. (Ed.), Mononuclear Phagocytes: Biology of Monocytes and Macrophages (pp. 233-240) Dordrecht , Netherlands: Kluwer Academic Publishers. doi:10.1007/978-94-015-8070-0

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A. and Mabbott, Neil A. (2018) The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nature Communications, 9 1: . doi:10.1038/s41467-018-03638-6

Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system

Hawley, Catherine A., Rojo, Rocio, Raper, Anna, Sauter, Kristin A., Lisowski, Zofia M., Grabert, Kathleen, Bain, Calum C., Davis, Gemma M., Louwe, Pieter A., Ostrowski, Michael C., Hume, David A., Pridans, Clare and Jenkins, Stephen J. (2018) Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system. Journal of Immunology, 200 6: 2209-2223. doi:10.4049/jimmunol.1701488

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats

Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018) Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 3: G388-G398. doi:10.1152/ajpgi.00343.2017

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

Baillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A., Hacohen, Nir, Freeman, Thomas C., Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair R. R. and Hume, David A. (2018) Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 3: . doi:10.1371/journal.pcbi.1005934

An update on equine postoperative ileus: Definitions, pathophysiology and management

Lisowski, Z. M., Pirie, R. S., Blikslager, A. T., Lefebvre, D., Hume, D. A. and Hudson, N. P. H. (2018) An update on equine postoperative ileus: Definitions, pathophysiology and management. Equine Veterinary Journal, . doi:10.1111/evj.12801

Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages

Regan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018) Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 4: 681-692. doi:10.1002/JLB.3A0617-261R

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder

Leday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Carvalho, Livia, Bell, Joshua, Souza-Teodoro, Luis, Perry, Hugh, Harrison, Neil, Drevets, Wayne, Wittenberg, Gayle, Jones, Declan, Bullmore, Edward, Khan, Shahid, Stylianou, Annie, Henderson, Robbie, Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M. and Bullmore, Edward T. (2018) Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder. Biological Psychiatry, 83 1: 70-80. doi:10.1016/j.biopsych.2017.01.021

Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci

Jubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017) Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 11: 3022-3031. doi:10.1016/j.celrep.2017.11.053

The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates

Hume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio and Pridans, Clare (2017) The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates. Scientific Reports, 7 1: 1-10. doi:10.1038/s41598-017-15999-x

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Farro, Giovanna, Stakenborg, Michelle, Gomez-Pinilla, Pedro J., Labeeuw, Evelien, Goverse, Gera, Giovangiulio, Martina Di, Stakenborg, Nathalie, Meroni, Elisa, D'Errico, Francesca, Elkrim, Yvon, Laoui, Damya, Lisowski, Zofia M., Sauter, Kristin A., Hume, David A., Van Ginderachter, Jo A., Boeckxstaens, Guy E. and Matteoli, Gianluca (2017) CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. Gut, 66 12: 2098-2109. doi:10.1136/gutjnl-2016-313144

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017) CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, . doi:10.1016/j.biomaterials.2017.10.033

A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

Clark, Emily L., Bush, Stephen J., McCulloch, Mary E. B., Farquhar, Iseabail L., Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C. Bruce, Freeman, Tom C., Summers, Kim M., Archibald, Alan L. and Hume, David A. (2017) A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics, 13 9: . doi:10.1371/journal.pgen.1006997

Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology

Macdonald, Sarah E., Nolan, Matthew J., Harman, Kimberley, Boulton, Kay, Hume, David A., Tomley, Fiona M., Stabler, Richard A. and Blake, Damer P. (2017) Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12 9: . doi:10.1371/journal.pone.0184890

The genomic architecture of mastitis resistance in dairy sheep

Banos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., Schulze, G., Arsenos, G., Hume, D. A. and Psifidi, A. (2017) The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18 1: 1-18. doi:10.1186/s12864-017-3982-1

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter, Axton, Richard A., Babina, Magda, Baillie, J. Kenneth, Barnett, Timothy C., Beckhouse, Anthony G., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Carlisle, Ailsa J., Clevers, Hans C., Davis, Carrie A., Detmar, Michael, Dohi, Taeko, Edge, Albert S. B., Edinger, Matthias, Ehrlund, Anna, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Farach-Carson, Mary C., Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E., Forrester, Lesley M., Fujita, Rie, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gingeras, Thomas, Goldowitz, Daniel, Guhl, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Hasegawa, Yuki, Herlyn, Meenhard, Heutink, Peter, Hitchens, Kelly J., Hume, David A., Ikawa, Tomokatsu, Ishizu, Yuri, Kai, Chieko, Kawamoto, Hiroshi, Kawamura, Yuki I., Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klein, Sarah, Klinken, S. Peter, Knox, Alan J., Kojima, Soichi, Koseki, Haruhiko, Koyasu, Shigeo, Lee, Weonju, Lennartsson, Andreas, Mackay-sim, Alan, Mejhert, Niklas, Mizuno, Yosuke, Morikawa, Hiromasa, Morimoto, Mitsuru, Moro, Kazuyo, Morris, Kelly J., Motohashi, Hozumi, Mummery, Christine L., Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Passier, Robert, Patrikakis, Margaret, Pombo, Ana, Pradhan-Bhatt, Swati, Qin, Xian-Yang, Rehli, Michael, Rizzu, Patrizia, Roy, Sugata, Sajantila, Antti, Sakaguchi, Shimon, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schmidl, Christian, Schneider, Claudio, Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sheng, Guojun, Shin, Jay W., Sugiyama, Daisuke, Sugiyama, Takaaki, Summers, Kim M., Takahashi, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tomoiu, Andru, Toyoda, Hiroo, van de Wetering, Marc, van den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Wells, Christine A., Winteringham, Louise N., Wolvetang, Ernst, Yamaguchi, Yoko, Yamamoto, Masayuki, Yanagi-Mizuochi, Chiyo, Yoneda, Misako, Yonekura, Yohei, Zhang, Peter G., Zucchelli, Silvia, Abugessaisa, Imad, Arner, Erik, Harshbarger, Jayson, Kondo, Atsushi, Lassmann, Timo, Lizio, Marina, Sahin, Serkan, Sengstag, Thierry, Severin, Jessica, Shimoji, Hisashi, Suzuki, Masanori, Suzuki, Harukazu, Kawai, Jun, Kondo, Naoto, Itoh, Masayoshi, Daub, Carsten O., Kasukawa, Takeya, Kawaji, Hideya, Carninci, Piero, Forrest, Alistair R. R. and Hayashizaki, Yoshihide (2017) FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 . doi:10.1038/sdata.2017.112

Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus

Rojo, Rocio, Pridans, Clare, Langlais, David and Hume, David A. (2017) Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science, 131 16: 2161-2182. doi:10.1042/CS20170238

Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data

Summers, Kim M. and Hume, David A. (2017) Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. Journal of Leukocyte Biology, 102 4: 1081-1092. doi:10.1189/jlb.1A0417-150RR

Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries

Bush, Stephen J., McCulloch, Mary E.B., Summers, Kim M., Hume, David A. and Clark, Emily L. (2017) Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries. BMC Bioinformatics, 18 1: . doi:10.1186/s12859-017-1714-9

Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions

Kwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017) Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 . doi:10.3389/fgene.2017.00032

Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA

Wu, Zhiguang, Hu, Tuanjun, Rothwell, Lisa, Vervelde, Lonneke, Kaiser, Pete, Boulton, Kay, Nolan, Matthew J., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2016) Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63 206-212. doi:10.1016/j.dci.2016.04.016

Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs

Sauter, Kristin A., Waddell, Lindsey A., Lisowski, Zofia M., Young, Rachel, Lefevre, Lucas, Davis, Gemma M., Clohisey, Sara M., McCulloch, Mary, Magowan, Elizabeth, Mabbott, Neil A., Summers, Kim M. and Hume, David A. (2016) Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311 3: G533-G547. doi:10.1152/ajpgi.00116.2016

Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016) Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 1: 7-16. doi:10.1038/icb.2016.74

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016) Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61 12-21. doi:10.1016/j.semcdb.2016.08.009

Comparative transcriptome analysis of equine alveolar macrophages

Karagianni, A. E., Kapetanovic, R., Summers, K. M., Mcgorum, B. C., Hume, D. A. and Pirie, R. S. (2016) Comparative transcriptome analysis of equine alveolar macrophages. Equine Veterinary Journal, 49 3: 375-382. doi:10.1111/evj.12584

Functional annotation of the T-cell immunoglobulin mucin family in birds

Hu, Tuanjun, Wu, Zhiguang, Vervelde, Lonneke, Rothwell, Lisa, Hume, David A. and Kaiser, Pete (2016) Functional annotation of the T-cell immunoglobulin mucin family in birds. Immunology, 148 3: 287-303. doi:10.1111/imm.12607

Transcriptional regulation and macrophage differentiation

Hume, David A., Summers, Kim M. and Rehli, Michael (2016) Transcriptional regulation and macrophage differentiation. Microbiology Spectrum, 4 3: 1-19. doi:10.1128/microbiolspec.MCHD-0024-2015

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016) Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59 145-152. doi:10.1016/j.dci.2016.01.023

Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages

Jubb, Alasdair W., Young, Robert S., Hume, David A. and Bickmore, Wendy A. (2016) Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages. Journal of Immunology, 196 2: 813-822. doi:10.4049/jimmunol.1502009

The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens

Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P. M., Kuo, R., Smith, J., Hocking, P. M., Salmon, N., Jones, M. A., Hume, D. A., Banos, G., Stevens, M. P. and Kaiser, P. (2016) The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17 1: . doi:10.1186/s12864-016-2612-7

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Alam, Intikhab, Albanese, Davide, Altschuler, Gabriel M., Arakawa, Takahiro, Archer, John A. C., Arner, Peter, Babina, Magda, Baker, Sarah, Balwierz, Piotr J., Beckhouse, Anthony G., Pradhan, Swati, Blake, Judith A., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Burroughs, A. Maxwell, Califano, Andrea, Cannistraci, Carlo V., Carbajo, Daniel, Chen, Yun, Chierici, Marco, Ciani, Yari, Clevers, Hans C., Dalla, Emiliano, Davis, Carrie A., Detmar, Michael, Diehl, Alexander D., Dohi, Taeko, Drablos, Finn, Edge, Albert S. B., Edinger, Matthias, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Fagiolini, Michela, Fairbairn, Lynsey, Fang, Hai, Farach-Carson, Mary C., Faulkner, Geoffrey J., Favorov, Alexander V., Fisher, Malcolm E., Frith, Martin C., Fujita, Rie, Fukuda, Shiro, Furlanello, Cesare, Furuno, Masaaki, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gibson, Andrew ., Gingeras, Thomas, Goldowitz, Daniel, Gough, Julian, Guhl, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Harbers, Matthias, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Takehiro, Herlyn, Meenhard, Hitchens, Kelly J., Ho Sui, Shannan J., Hofmann, Oliver M., Hoof, Ilka, Hori, Fumi, Huminiecki, Lukasz, Iida, Kei, Ikawa, Tomokatsu, Jankovic, Boris R., Jia, Hui, Joshi, Anagha, Jurman, Giuseppe, Kaczkowski, Bogumil, Kai, Chieko, Kaida, Kaoru, Kaiho, Ai, Kajiyama, Kazuhiro, Kanamori-Katayama, Mutsumi, Kasianov, Artem S., Kasukawa, Takeya, Katayama, Shintaro, Kato, Sachi, Kawaguchi, Shuji, Kawamoto, Hiroshi, Kawamura, Yuki I., Kawashima, Tsugumi, Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klinken, S. Peter, Knox, Alan J., Kojima, Miki, Kojima, Soichi, Kondo, Naoto, Koseki, Haruhiko, Koyasu, Shigeo, Krampitz, Sarah, Kubosaki, Atsutaka, Kwon, Andrew T., Laros, Jeroen F. J., Lee, Weonju, Lennartsson, Andreas, Li, Kang, Lilje, Berit, Lipovich, Leonard, Mackay, Alan, Manabe, Riichiroh, Mar, Jessica C., Marchand, Benoit, Mathelier, Anthony, Mejhert, Niklas, Meynert, Alison, Mizuno, Yosuke, de Lima Morais, David A., Morikawa, Hiromasa, Morimoto, Mitsuru., Moro, Kazuyo, Motakis, Efthymios, Motohashi, Hozumi, Mummery, Christine L., Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nakazato, Kenichi, van Nimwegen, Erik, Ninomiya, Noriko, Nishiyori, Hiromi, Noma, Shohei, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohmiya, Hiroko, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Pain, Arnab, Passier, Robert, Patrikakis, Margaret, Persson, Helena, Piazza, Silvano, Prendergast, James G. D., Rackham, Owen J. ., Ramilowski, Jordan A., Rashid, Mamoon, Ravasi, Timothy, Rizzu, Patrizia, Roncador, Marco, Roy, Sugata, Rye, Morten B., Saijyo, Eri, Sajantila, Antti, Saka, Akiko, Sakaguchi, Shimon, Sakai, Mizuho, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schneider, Claudio, Schultes, Erik A., Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sengstag, Thierry, Sheng, Guojun, Shimoji, Hisashi, Shimoni, Yishai, Shin, Jay W., Simon, Christophe, Sugiyama, Daisuke, Sugiyama, Takaaki, Suzuki, Masanori, Suzuki, Naoko, Swoboda, Rolf K., 't Hoen, Peter A.C., Tagami, Michihira, Takahashi, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tatum, Zuotian, Thompson, Mark, Toyoda, Hiroo, Toyoda, Tetsuro, Valen, Eivind, van de Wetering, Marc, van den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Vorontsov, Ilya E., Wasserman, Wyeth W., Watanabe, Shoko, Wells, Christine A., Winteringham, Louise N., Wolvetang, Ernst, Wood, Emily J., Yamaguchi, Yoko, Yamamoto, Masayuki, Yoneda, Misako, Yonekura, Yohei, Yoshida, Shigehiro, Zabierowski, Suzan E., Zhang, Peter G., Zhao, Xiaobei, Zucchelli, Silvia, Summers, Kim M., Suzuki, Harukazu, Daub, Carsten O., Kawai, Jun, Heutink, Peter, Hide, Winston, Freeman, Tom C., Lenhard, Boris, Bajic, Vladimir B., Taylor, Martin S., Makeev, Vsevolod J., Sandelin, Albin, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2015) The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 12: . doi:10.1371/journal.pbio.1002315

CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure

Stutchfield, Benjamin M., Antoine, Daniel J., Mackinnon, Alison C., Gow, Deborah J., Bain, Calum C., Hawley, Catherine A., Hughes, Michael J., Francis, Benjamin, Wojtacha, Davina, Man, Tak Y., Dear, James W., Devey, Luke R., Mowat, Alan M., Pollard, Jeffrey W., Park, B. Kevin, Jenkins, Stephen J., Simpson, Kenneth J., Hume, David A., Wigmore, Stephen J. and Forbes, Stuart J. (2015) CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology, 149 7: 1896-1909. doi:10.1053/j.gastro.2015.08.053

Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome

Robert, Christelle, Kapetanovic, Ronan, Beraldi, Dario, Watson, Mick, Archibald, Alan L. and Hume, David A. (2015) Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome. BMC Genomics, 16 1: 970.1-970.17. doi:10.1186/s12864-015-2111-2

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015) Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 304: 1-10. doi:10.1126/scitranslmed.aaa3863

Immune surveillance of the lung by migrating tissue monocytes

Rodero, Mathieu P., Poupel, Lucie, Loyher, Pierre-Louis, Hamon, Pauline, Licata, Fabrice, Pessel, Charlotte, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2015) Immune surveillance of the lung by migrating tissue monocytes. eLife, 4 1-23. doi:10.7554/eLife.07847

A transcriptional perspective on human macrophage biology

Schultze, Joachim L., Freeman, Tom, Hume, David A. and Latz, Eicke (2015) A transcriptional perspective on human macrophage biology. Seminars in Immunology, 27 1: 44-50. doi:10.1016/j.smim.2015.02.001

The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor

Garceau, Valerie, Balic, Adam, Garcia-Morales, Carla, Sauter, Kristin A., McGrew, Mike J., Smith, Jacqueline, Vervelde, Lonneke, Sherman, Adrian, Fuller, Troy E., Oliphant, Theodore, Shelley, John A., Tiwari, Raksha, Wilson, Thomas L., Chintoan-Uta, Cosmin, Burt, Dave W., Stevens, Mark P., Sang, Helen M. and Hume, David A. (2015) The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor. BMC Biology, 13 1: 12.1-12.17. doi:10.1186/s12915-015-0121-9

Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages

Garcia-Morales, Carla, Nandi, Sunil, Zhao, Debiao, Sauter, Kristin A., Vervelde, Lonneke, McBride, Derek, Sang, Helen M., Clinton, Mike and Hume, David A. (2015) Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages. Journal of Immunology, 194 5: 2338-2344. doi:10.4049/jimmunol.1401982

Exome sequencing: current and future perspectives

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan, Deeb, Nader and Watson, Mick (2015) Exome sequencing: current and future perspectives. G3: Genes, Genomes, Genetics, 5 8: 1543-1550. doi:10.1534/g3.115.018564

Identification of low-confidence regions in the pig reference genome (Sscrofa10.2)

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan L., Deeb, Nader and Watson, Mick (2015) Identification of low-confidence regions in the pig reference genome (Sscrofa10.2). Frontiers in Genetics, 6 NOV: . doi:10.3389/fgene.2015.00338

Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma

Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen M., Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., Van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25 5: 577-588. doi:10.1016/j.cub.2014.12.059

Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells

Joshi, Anagha, Pooley, Christopher, Freeman, Tom C., Lennartsson, Andreas, Babina, Magda, Schmidl, Christian, Geijtenbeek, Teunis, Michoel, Tom, Severin, Jessica, Itoh, Masayoshi, Lassmann, Timo, Kawaji, Hideya, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair R. R., Rehli, Michael and Hume, David A. (2015) Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells. Journal of Leukocyte Biology, 97 5: 985-995. doi:10.1189/jlb.6TA1014-477RR

Third Report on Chicken Genes and Chromosomes 2015:

Schmid, Michael, Smith, Jacqueline, Burt, David W., Aken, Bronwen L., Antin, Parker B., Archibald, Alan L., Ashwell, Chris, Blackshear, Perry J., Boschiero, Clarissa, Brown, C. Titus, Burgess, Shane C., Cheng, Hans H., Chow, William, Coble, Derrick J., Cooksey, Amanda, Crooijmans, Richard P.M.A., Damas, Joana, Davis, Richard V.N., De Koning, Dirk-Jan, Delany, Mary E., Derrien, Thomas, Desta, Takele T., Dunn, Ian C., Dunn, Matthew, Ellegren, Hans, Eöry, Lél, Erb, Ionas, Farré, Marta, Fasold, Mario, Fleming, Damarius, Flicek, Paul, Fowler, Katie E., Frésard, Laure, Froman, David P., Garceau, Valerie, Gardner, Paul P., Gheyas, Almas A., Griffin, Darren K., Groenen, Martien A.M., Haaf, Thomas, Hanotte, Olivier, Hart, Alan, Häsler, Julien, Hedges, S. Blair, Hertel, Jana, Howe, Kerstin, Hubbard, Allen, Hume, David A., Kaiser, Pete, Kedra, Darek, Kemp, Stephen J., Klopp, Christophe, Kniel, Kalmia E., Kuo, Richard, Lagarrigue, Sandrine, Lamont, Susan J., Larkin, Denis M., Lawal, Raman A., Markland, Sarah M., McCarthy, Fiona, McCormack, Heather A., McPherson, Marla C., Motegi, Akira, Muljo, Stefan A., Münsterberg, Andrea, Nag, Rishi, Nanda, Indrajit, Neuberger, Michael, Nitsche, Anne, Notredame, Cedric, Noyes, Harry, O'Connor, Rebecca, O'Hare, Elizabeth A., Oler, Andrew J., Ommeh, Sheila C., Pais, Helio, Persia, Michael, Pitel, Frédérique, Preeyanon, Likit, Prieto Barja, Pablo, Pritchett, Elizabeth M., Rhoads, Douglas D., Robinson, Charmaine M., Romanov, Michael N., Rothschild, Max, Roux, Pierre-François, Schmidt, Carl J., Schneider, Alisa-Sophia, Schwartz, Matthew G., Searle, Steve M., Skinner, Michael A., Smith, Craig A., Stadler, Peter F., Steeves, Tammy E., Steinlein, Claus, Sun, Liang, Takata, Minoru, Ulitsky, Igor, Wang, Qing, Wang, Ying, Warren, Wesley C., Wood, Jonathan M.D., Wragg, David and Zhou, Huaijun (2015) Third Report on Chicken Genes and Chromosomes 2015:. Cytogenetic and Genome Research, 145 2: 78-179. doi:10.1159/000430927

Transcriptomic analysis of mononuclear phagocyte differentiation and activation

Hume, David A. and Freeman, Tom C. (2014) Transcriptomic analysis of mononuclear phagocyte differentiation and activation. Immunological Reviews, 262 1: 74-84. doi:10.1111/imr.12211

The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Bain, Calum C., Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M., Davies, Claire L., Donaldson, David S., Renault, Kathleen, McColl, Barry W., Mowat, Alan M., Serrels, Alan, Frame, Margaret C., Mabbott, Neil A. and Hume, David A. (2014) The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration. PLoS ONE, 9 8: . doi:10.1371/journal.pone.0105429

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Raza, Sobia, Barnett, Mark W., Barnett-Itzhaki, Zohar, Amit, Ido, Hume, David A. and Freeman, Tom C. (2014) Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. Journal of Leukocyte Biology, 96 2: 167-183. doi:10.1189/jlb.6HI0313-169R

Design and development of exome capture sequencing for the domestic pig (Sus scrofa)

Robert, Christelle, Fuentes-Utrilla, Pablo, Troup, Karen, Loecherbach, Julia, Turner, Frances, Talbot, Richard, Archibald, Alan L., Mileham, Alan, Deeb, Nader, Hume, David A. and Watson, Mick (2014) Design and development of exome capture sequencing for the domestic pig (Sus scrofa). BMC Genomics, 15 1: . doi:10.1186/1471-2164-15-550

Transcriptional switching in macrophages associated with the peritoneal foreign body response

Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014) Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 6: 518-526. doi:10.1038/icb.2014.19

Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells

Garcia-Morales, Carla, Rothwell, Lisa, Moffat, Lindsey, Garceau, Valerie, Balic, Adam, Sang, Helen M., Kaiser, Pete and Hume, David A. (2014) Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells. Developmental and Comparative Immunology, 42 2: 278-285. doi:10.1016/j.dci.2013.09.011

Network analysis reveals distinct clinical syndromes underlying acute mountain sickness

Hall, David P., MacCormick, Ian J. C., Phythian-Adams, Alex T., Rzechorzek, Nina M., Hope-Jones, David, Cosens, Sorrel, Jackson, Stewart, Bates, Matthew G. D., Collier, David J., Hume, David A., Freeman, Thomas, Thompson, A. A. Roger and Baillie, John Kenneth (2014) Network analysis reveals distinct clinical syndromes underlying acute mountain sickness. PLoS ONE, 9 1: . doi:10.1371/journal.pone.0081229

A promoter-level mammalian expression atlas

Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab, Albanese, Davide, Altschule, Gabriel M., Arakawa, Takahiro, Archer, John A. C., Arner, Peter, Babina, Magda, Rennie, Sarah, Balwierz, Piotr J., Beckhouse, Anthony G., Pradhan-Bhatt, Swati, Blake, Judith A., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Burroughs, A. Maxwell, Califano, Andrea, Cannistraci, Carlo V., Carbajo, Daniel, Chen, Yun, Chierici, Marco, Ciani, Yari, Clevers, Hans C., Dalla, Emiliano, Davis, Carrie A., Detmar, Michael, Diehl, Alexander D., Dohi, Taeko, Drablos, Finn, Edge, Albert S. B., Edinger, Matthias, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Fagiolini, Michela, Fairbairn, Lynsey, Fang, Hai, Farach-Carson, Mary C., Faulkner, Geoffrey J., Favorov, Alexander V., Fisher, Malcolm E., Frith, Martin C., Fujita, Rie, Fukuda, Shiro, Furlanello, Cesare, Furuno, Masaaki, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gibson, Andrew P., Gingeras, Thomas, Goldowitz, Daniel, Gough, Julian, Guh, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Harbers, Matthias, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Takehiro, Herlyn, Meenhard, Hitchens, Kelly J., Sui, Shannan J. Ho, Hofmann, Oliver M., Hoof, Ilka, Hori, Fumi, Huminiecki, Lukasz, Iida, Kei, Ikawa, Tomokatsu, Jankovic, Boris R., Jia, Hui, Joshi, Anagha, Jurman, Giuseppe, Kaczkowski, Bogumil, Kai, Chieko, Kaida, Kaoru, Kaiho, Ai, Kajiyama, Kazuhiro, Kanamori-Katayama, Mutsumi, Kasianov, Artem S., Kasukawa, Takeya, Katayama, Shintaro, Kato, Sachi, Kawaguchi, Shuji, Kawamoto, Hiroshi, Kawamura, Yuki I., Kawashima, Tsugumi, Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klinken, S. Peter, Knox, Alan J., Kojima, Miki, Kojima, Soichi, Kondo, Naoto, Koseki, Haruhiko, Koyasu, Shigeo, Krampitz, Sarah, Kubosaki, Atsutaka, Kwon, Andrew T., Laros, Jeroen F. J., Lee, Weonju, Lennartsson, Andreas, Li, Kang, Lilje, Berit, Lipovich, Leonard, Mackay-sim, Alan, Manabe, Ri-ichiroh, Mar, Jessica C., Marchand, Benoit, Mathelier, Anthony, Mejhert, Niklas, Meynert, Alison, Mizuno, Yosuke, De Lima Morais, David A., Morikawa, Hiromasa, Morimoto, Mitsuru, Moro, Kazuyo, Motakis, Efthymios, Motohashi, Hozumi, Mummer, Christine L., Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nakazato, Kenichi, Van Nimwegen, Erik, Ninomiya, Noriko, Nishiyori, Hiromi, Noma, Shohei, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohmiya, Hiroko, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Pain, Arnab, Passier, Robert, Patrikakis, Margaret, Persson, Helena, Piazza, Silvano, Prendergast, James G. D., Rackham, Owen J. L., Ramilowski, Jordan A., Rashid, Mamoon, Ravasi, Timothy, Rizzu, Patrizia, Roncador, Marco, Roy, Sugata, Rye, Morten B., Saijyo, Eri, Sajantila, Antti, Saka, Akiko, Sakaguchi, Shimon, Sakai, Mizuho, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schneider, Claudio, Schultes, Erik A., Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sengstag, Thierry, Sheng, Guojun, Shimoji, Hisashi, Shimoni, Yishai, Shin, Jay W., Simon, Christophe, Sugiyama, Daisuke, Sugiyama, Takaaki, Suzuki, Masanori, Suzuki, Naoko, Swoboda, Rolf K., 'T Hoen, Peter A. C., Tagami, Michihira, Takahash, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tatum, Zuotian, Thompson, Mark, Toyoda, Hiroo, Toyoda, Tetsuro, Valen, Eivind, Van De Wetering ,Marc, Van Den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Vorontsov, Ilya E., Wasserman, Wyeth W., Watanabe, Shoko, Wells, Christine A., Winteringham,Louise N., Wolvetang, Ernst, Wood, Emily J., Yamaguchi, Yoko, Yamamoto, Masayuki, Yoneda, Misako, Yonekura, Yohei, Yoshida, Shigehiro, Zabierowski, Susan E., Zhang, Peter G., Zhao, Xiaobei, Zucchelli, Silvia, Summers, Kim M., Suzuki, Harukazu, Daub, Carsten O., Kawai, Jun, Heutink, Peter, Hide, Winston, Freeman, Tom C., Lenhard, Boris, Bajic, Vladimir B., Taylor, Martin S., Makeev, Vsevolod J., Sandelin, Albin, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2014) A promoter-level mammalian expression atlas. Nature, 507 7493: 462-470. doi:10.1038/nature13182

Characterisation of a novel fc conjugate of macrophage colony-stimulating factor

Gow, Deborah J, Sauter, Kristin A., Pridans, Clare, Moffat, Lindsey, Sehgal, Anuj, Stutchfield, Ben M., Raza, Sobia, Beard, Philippa M., Tsai, Yi Ting, Bainbridge, Graeme, Boner, Pamela L., Fici, Greg, Garcia-Tapia, David, Martin, Roger A., Oliphant, Theodore, Shelly, John A., Tiwari, Raksha, Wilson, Thomas L., Smith, Lee B., Mabbott, Neil A. and Hume, David A. (2014) Characterisation of a novel fc conjugate of macrophage colony-stimulating factor. Molecular Therapy, 22 9: 1580-1592. doi:10.1038/mt.2014.112

Homeostasis in the mononuclear phagocyte system

Jenkins, Stephen J. and Hume, David A. (2014) Homeostasis in the mononuclear phagocyte system. Trends in Immunology, 35 8: 358-367. doi:10.1016/j.it.2014.06.006

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B. and Hume, David A. (2014) Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 96 2: 265-274. doi:10.1189/jlb.2A0114-006R

Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage

Balic, Adam, Garcia-Morales, Carla, Vervelde, Lonneke, Gilhooley, Hazel, Sherman, Adrian, Garceau, Valerie, Gutowska, Maria W., Burt, David W., Kaiser, Pete, Hume, David A. and Sang, Helen M. (2014) Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage. Development, 141 16: 3255-3265. doi:10.1242/dev.105593

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function

Pridans, Clare, Sauter, Kristin A., Baer, Kristin, Kissel, Holger and Hume, David A. (2013) CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function. Scientific Reports, 3 . doi:10.1038/srep03013

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

Jenkins, Stephen J., Ruckerl, Dominik, Thomas, Graham D., Hewitson, James P., Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M., Hume, David A. and Allen, Judith E. (2013) IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. Journal of Experimental Medicine, 210 11: 2477-2491. doi:10.1084/jem.20121999

The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages

Karagianni, Anna E., Kapetanovic, Ronan, McGorum, Bruce C., Hume, David A. and Pirie, Scott R. (2013) The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages. Veterinary Immunology And Immunopathology, 155 4: 219-228. doi:10.1016/j.vetimm.2013.07.003

An expression atlas of human primary cells: inference of gene function from coexpression networks

Mabbott, Neil A., Baillie, J. K., Brown, Helen, Freeman, Tom C. and Hume, David A. (2013) An expression atlas of human primary cells: inference of gene function from coexpression networks. BMC Genomics, 14 1: . doi:10.1186/1471-2164-14-632

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide

Kapetanovic, Ronan, Fairbairn, Lynsey, Downing, Alison, Beraldi, Dario, Sester, David P., Freeman, Tom C., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2013) The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. Bmc Genomics, 14 1: . doi:10.1186/1471-2164-14-581

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013) Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 35: 25362-25374. doi:10.1074/jbc.M113.496281

Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli

Dave, Richa K., Dinger, Marcel E., Andrew, Megan, Askarian-Amiri, Marjan, Hume, David A. and Kellie, Stuart (2013) Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli. PLoS One, 8 6: e68306.1-e68306.13. doi:10.1371/journal.pone.0068306

Can DCs be distinguished from macrophages by molecular signatures?

Hume, David A., Mabbott, Neil, Raza, Sobia and Freeman, Tom C. (2013) Can DCs be distinguished from macrophages by molecular signatures?. Nature Immunology, 14 3: 187-189. doi:10.1038/ni.2516

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

Gow, Deborah J., Garceau, Valerie, Pridans, Clare, Gow, Adam G., Simpson, Kerry E., Gunn-Moore, Danielle and Hume, David A. (2013) Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 61 2: 630-638. doi:10.1016/j.cyto.2012.11.014

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, David A., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013) Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity, 38 1: 79-91. doi:10.1016/j.immuni.2012.12.001

The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus

Sauter, Kristin A., Bouhlel, M. Amine, O'Neal, Julie, Sester, David P., Tagoh, Hiromi, Ingram, Richard M. I, Pridans, Clare, Bonifer, Constanze and Hume, David A. (2013) The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus. PLoS One, 8 1: . doi:10.1371/journal.pone.0054935

A gene expression atlas of the domestic pig

Freeman, Tom C., Ivens, Alasdair, Baillie, J. Kenneth, Beraldi, Dario, Barnett, Mark W., Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I., Summers, Kim M., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2012) A gene expression atlas of the domestic pig. BMC Biology, 10 9: . doi:10.1186/1741-7007-10-90

Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes

Hume, David A. (2012) Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes. Journal of Leukocyte Biology, 92 3: 433-444. doi:10.1189/jlb.0312166

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012) Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 16: E944-E953. doi:10.1073/pnas.1110156109

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt, Aaron R., Clare, Simon, Pertel, Thomas, John, Sinu P., Wash, Rachael S., Smith, Sarah E., Chin, Christopher R., Feeley, Eric M., Sims, Jennifer S., Adams, David J., Wise, Helen M., Kane, Leanne, Goulding, David, Digard, Paul, Anttila, Verneri, Baillie, J. Kenneth, Walsh, Tim S., Hume, David A., Palotie, Aarno, Xue, Yali, Colonna, Vincenza, Tyler-Smith, Chris, Dunning, Jake, Gordon, Stephen B., Smyth, Rosalind L., Openshaw, Peter J., Dougan, Gordon, Brass, Abraham L. and Kellam, Paul (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature, 484 7395: 519-523. doi:10.1038/nature10921

Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide

Kapetanovic, Ronan, Fairbairn, Lynsey, Beraldi, Dario, Sester, David P., Archibald, Alan L., Tuggle, Christopher K. and Hume, David A. (2012) Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. The Journal of Immunology, 188 7: 3382-3394. doi:10.4049/jimmunol.1102649

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

Hume, David A. and MacDonald, Kelli P. A. (2012) Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood, 119 8: 1810-1820. doi:10.1182/blood-2011-09-379214

Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages

Bradford, Barry M., Sester, David P., Hume, David A. and Mabbott, Neil A. (2011) Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. Immunobiology, 216 11: 1228-1237. doi:10.1016/j.imbio.2011.08.006

Macrophages.com: an on-line community resource for innate immunity research

Robert, Christelle, Lu, Xiang, Law, Andrew, Freeman, Tom C. and Hume, David A. (2011) Macrophages.com: an on-line community resource for innate immunity research. Immunobiology, 216 11: 1203-1211. doi:10.1016/j.imbio.2011.07.025

Somatic retrotransposition alters the genetic landscape of the human brain

Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan. Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A. and Faulkner, Geoffrey J. (2011) Somatic retrotransposition alters the genetic landscape of the human brain. Nature, 479 7374: 534-537. doi:10.1038/nature10531

Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher , Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A. and Ricardo, Sharon D. (2011) Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. The American Journal of Pathology, 179 3: 1243-1256. doi:10.1016/j.ajpath.2011.05.037

Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011) Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 7: 1517-1532. doi:10.1002/jbmr.354

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, James A., Pope, Caroline, Wojtacha, Davina, Robson, Andrew J., Gordon-Walker, Timothy T., Hartland, Stephen, Ramachandran, Prakash, Van Deemter, Marielle, Hume, David A., Iredale, John P. and Forbes, Stuart J. (2011) Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology, 53 6: 2003-2015. doi:10.1002/hep.24315

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P. and Hume, David A. (2011) The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. Journal of Leukocyte Biology, 89 6: 855-871. doi:10.1189/jlb.1110607

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

Hume, David A. (2011) Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. Journal of Leukocyte Biology, 89 4: 525-538. doi:10.1189/jlb.0810472

The future of animal production: improving productivity and sustainability

Hume, D. A., Whitelaw, C. B. A. and Archibald, A. L. (2011) The future of animal production: improving productivity and sustainability. Journal of Agricultural Science, 149 S1: 9-16. doi:10.1017/S0021859610001188

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011) Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 1: e15723-1-e15723-13. doi:10.1371/journal.pone.0015723

Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: Implications for phenotypic variability in Marfan syndrome

Summers, Kim M., Raza, Sobia, van Nimwegen, Erik, Freeman, Thomas C. and Hume, David A. (2010) Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: Implications for phenotypic variability in Marfan syndrome. European Journal of Human Genetics, 18 11: 1209-1215. doi:10.1038/ejhg.2010.91

CSF-1, IGF-1, and the control of postnatal growth and development

Gow, Deborah J., Sester, David P. and Hume, David A. (2010) CSF-1, IGF-1, and the control of postnatal growth and development. Journal of Leukocyte Biology, 88 3: 475-481. doi:10.1189/jlb.0310158

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

Mabbott, Neil A., Baillie, J. Kenneth, Hume, David A. and Freeman, Tom C. (2010) Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology, 215 9-10: 724-736. doi:10.1016/j.imbio.2010.05.012

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010) The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 14: 2295-2302. doi:10.1016/j.molimm.2010.05.289

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010) Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 6: 1103-1114. doi:10.1189/jlb.0509363

Functional clustering and lineage markers: Insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations

Hume, David A., Summers, Kim M., Raza, Sobia, Baillie, J. Kenneth and Freeman, Thomas C. (2010) Functional clustering and lineage markers: Insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations. Genomics, 95 6: 328-338. doi:10.1016/j.ygeno.2010.03.002

A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice

Ovchinnikov, Dmitry A., DeBats, Claire E. E., Sester, David P., Sweet, Matthew J. and Hume, David A. (2010) A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. Journal of Leukocyte Biology, 87 5: 815-822. doi:10.1189/jlb.0809557

Unravelling mononuclear phagocyte heterogeneity

Geissmann, Frederic, Gordon, Siamon, Hume, David A., Mowat, Allan M. and Randolph, Gwendalyn J. (2010) Unravelling mononuclear phagocyte heterogeneity. Nature Reviews Immunology, 10 6: 453-460. doi:10.1038/nri2784

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae

Ripoll, Vera M., Kadioglu, Aras, Cox, Roger, Hume, David A. and Denny, Paul (2010) Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. Journal of Leukocyte Biology, 87 4: 735-741. doi:10.1189/jlb.0509359

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase

Weber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010) Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 2: 447-454. doi:10.1016/j.ejmech.2009.10.025

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

Deng, Lin, Zhou, Jin-Feng, Sellers, Rani S., Li, Jiu-Feng, Nguyen, Andrew V., Wang, Yubao, Orlofsky, Amos, Liu, Qiang, Hume, David A., Pollard, Jeffrey W., Augenlicht, Leonard and Lin, Elaine Y. (2010) A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. American Journal of Pathology, 176 2: 952-967. doi:10.2353/ajpath.2010.090622

Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response

Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010) Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 1: 369-380. doi:10.2353/ajpath.2010.090545

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

Forrest, A. R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., De Hoon, M. J.L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010) Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia, 24 2: 460-466. doi:10.1038/leu.2009.246

Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1

Summers, Kim M., Bokil, Nilesh J., Baisden, John M., West, Malcolm J., Sweet, Matthew J., Raggatt, Liza J. and Hume, David A. (2009) Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1. Genomics, 94 4: 233-240. doi:10.1016/j.ygeno.2009.06.005

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration

Ebert, Stefanie, Weigelt, Karin, Walczak, Yana, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009) Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. Journal of Neurochemistry, 110 6: 1863-1875. doi:10.1111/j.1471-4159.2009.06286.x

Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling

Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009) Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 3: 326-337. doi:10.1111/j.1365-2567.2008.02979.x

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

Dave, R. K., Hume, D. A., Elsegood, C and Kellie, S (2009) CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Experimental Cell Research, 315 10: 1734-1744. doi:10.1016/j.yexcr.2009.02.023

The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009) The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 4: . doi:10.1186/gb-2009-10-4-r40

FANTOM4 EdgeExpressDB: An integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions

Severin, Jessica, Waterhouse, Andrew M., Kawaji, Hideya, Lassmann, Timo, van Nimwegen, Erik, Balwierz, Piotr J., de Hoon, Michiel J. L., Hume, David A., Carninci, Piero, Hayashizaki, Yoshihide, Suzuki, Harukazu, Daub, Carsten O. and Forrest, Alistair R. R. (2009) FANTOM4 EdgeExpressDB: An integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions. Genome Biology, 10 4: . doi:10.1186/gb-2009-10-4-r39

CX 3CR1 + CD115 + CD135 + common macrophage/DC precursors and the role of CX 3CR1 in their response to inflammation

Auffray, Cedric, Fogg, Darin K., Narni-Mancinelli, Emilie, Senechal, Brigitte, Trouillet, Celine, Saederup, Noah, Leemput, Julia, Bigot, Karine, Campisi, Laura, Abitbol, Marc, Molina, Thierry, Charo, Israel, Hume, David A., Cumano, Ana, Lauvau, Gregoire and Geissmann, Frederic (2009) CX 3CR1 + CD115 + CD135 + common macrophage/DC precursors and the role of CX 3CR1 in their response to inflammation. Journal of Experimental Medicine, 206 3: 595-606. doi:10.1084/jem.20081385

TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium

Trieu, Angela, Bokil, Nilesh, Dunn, Jasmyn A., Roberts, Tara L., Xu, Damo, Liew, Foo Y., Hume, David A., Stacey, Katryn J. and Sweet, Matthew J. (2009) TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium. Immunology and Cell Biology, 87 3: 218-225. doi:10.1038/icb.2008.95

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 5917: 1057-1060. doi:10.1126/science.1169841

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009) Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 2: 278-288. doi:10.1189/jlb.0808497

Our evolving knowledge of the transcriptional landscape

Hume, David A. (2008) Our evolving knowledge of the transcriptional landscape. Mammalian Genome, 19 10-12: 663-666. doi:10.1007/s00335-008-9140-y

Macrophages as APC and the dendritic cell myth

Hume, David A. (2008) Macrophages as APC and the dendritic cell myth. Journal of Immunology, 181 9: 5829-5835. doi:10.4049/jimmunol.181.9.5829

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?

Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 1-8. doi:10.1186/1756-0500-1-78

Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry

King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008) Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 13: 5036-5043. doi:10.1021/ac702277q

Cortactin adopts a globular conformation and bundles actin into sheets

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008) Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 23: 16187-16193. doi:10.1074/jbc.M708917200

Increased TNF expression in CD43++ murine blood monocytes

Burke, Bernard, Ahmad, Rasheedah, Staples, Karl J., Snowden, Roger, Kadioglu, Aras, Frankenberger, Marion, Hume, David A. and Ziegler-Heitbrock, Loems (2008) Increased TNF expression in CD43++ murine blood monocytes. Immunology Letters, 118 2: 142-147. doi:10.1016/j.imlet.2008.03.012

The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

WellsChristineA, Salvage-JonesJudithA, LiXin, HitchensKelly, ButcherSuzanne, MurrayRachaelZ, Beckhouse, Anthony G., LoYu-Lan-Sandra, ManzaneroSilvia, CobboldChristian, SchroderKate, MaBo, OrrSally, StewartLauren, LebusDaniel, SobieszczukPeter, HumeDavidA, StowJennifer, BlanchardHelen, AshmanRobertB, RRich and MHogan (2008) The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology, 180 11: 7404-7413.

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene

Hume, David A., Sasmono, Tedjo, Himes, S. Roy, Sharma, Sudarshana M., Bronisz, Agnieszka, Constantin, Myrna, Ostrowski, Michael C. and Ross, Ian L. (2008) The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. The Journal of Immunology, 180 10: 6733-6742.

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo

Chang, Ming K., Raggatt, Liza-Jane, Alexander, Kylie A., Kuliwaba, Julia S., Fazzalari, Nicola L., Schroder, Kate, Maylin, Erin R., Ripoll, Vera M, Hume, David A. and Pettit, Allison R. (2008) Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo. The Journal of Immunology, 181 2: 1232-1244.

Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats

Pettit, Allison R., Hume, David A. and Raggatt, Liza-Jane (2008) Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats. Bone, 42 4: 825-825. doi:10.1016/j.bone.2007.12.217

Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity

Lang, P., Van Harmelen, V., Kaaman, M., Parini, P., Carneheim, C., Cassady, A. I., Hume, D. A., Andersson, G. and Arner, P. (2008) Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS One, 3 3: e1713-e1713. doi:10.1371/journal.pone.0001713

Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice

Ovchinnikov, Dmitry A., van Zuylen, Wendy J. M., DeBats, Claire E. E., Alexander, Kylie A., Kellie, Stuart and Hume, David A. (2008) Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. Journal of Leukocyte Biology, 83 2: 430-433. doi:10.1189/jlb.0807585

Bring out your dead

Hume, David A. (2008) Bring out your dead. Nature Immunology, 9 1: 12-14. doi:10.1038/ni0108-12

Differentiation and heterogeneity in the mononuclear phagocyte system

Hume, D. A. (2008) Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunology, 1 6: 432-441. doi:10.1038/mi.2008.36

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

Bonifer, Constanze and Hume, David A. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Frontiers in Bioscience-Landmark, 13 2: 549-560. doi:10.2741/2700

Systems biology of transcription control in macrophages

Ravasi, Timothy, Wells, Christine A. and Hume, David A. (2007) Systems biology of transcription control in macrophages. BioEssays, 29 12: 1215-1226. doi:10.1002/bies.20683

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

McMorran, Brendan J., Patat, Severine A. Ouvry, Carlin, John B., Grimwood, Keith, Jones, Alun, Armstrong, David S., Galati, John C., Cooper, Peter J., Byrnes, Catherine A., Francis, Paul W., Robertson, Colin F., Hume, David A., Borchers, Christoph H., Wainwright, Claire E. and Wainwright, Brandon J. (2007) Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53 10: 1782-1791. doi:10.1373/clinchem.2007.087650

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages

Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007) Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 6: 3495-3503.

G-protein-coupled receptor expression, function, and signaling in macrophages

Lattin, J., Zidar, D., Schroder, K., Kellie, S., Hume, D. and Sweet, M. (2007) G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology, 82 1: 16-32. doi:10.1189/jlb.0107051

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007) Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 25: 10382-10387. doi:10.1073/pnas.0700974104

The role of schlafen in macrophages and inflammation

van Zuijlen, WJM, Cook, AD, Ovchinnikov, DA, Kellie, S and Hume, DA (2007) The role of schlafen in macrophages and inflammation. Inflammation Research, 56 S389-S389.

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages

Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007) PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 6: 1577-1590. doi:10.1189/jlb.0107036

Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses

Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 10: 6557-6566.

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor

Meadows, Nicholas A., Sharma, Sudarshana M., Faulkner, Geoffrey J., Ostrowski, Michael C., Hume, David A. and Cassady, Alan I. (2007) The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. Journal of Biological Chemistry, 282 3: 1891-1904. doi:10.1074/jbc.M608572200

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

Rae, Fiona, Woods, Kyra, Sasmono, Tedjo, Campanale, Naomi, Taylor, Darrin, Ovchinnikov, Dmitry A., Grimmond, Sean M., Hume, David A., Ricardo, Sharon D. and Little, Melissa H. (2007) Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Developmental Biology, 308 1: 232-246. doi:10.1016/j.ydbio.2007.05.027

Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis

Hinshelwood, Rebecca A., Huschtscha, Lily I., Melki, John, Stirzaker, Clare, Abdipranoto, Andrea, Vissel, Bryce, Ravasi, Timothy, Wells, Christine A., Hume, David A., Reddel, Roger R. and Clark, Susan J. (2007) Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67 24: 11517-11527. doi:10.1158/0008-5472.CAN-07-1284

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

Bode, K. A., Schroder, K., Hume, D. A., Ravasi, T., Heeg, K., Sweet, M. J. and Dalpke, A. H. (2007) Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology, 122 4: 596-606. doi:10.1111/j.1365-2567.2007.02678.x

Mammalian RNA polymerase II core promoters: insights from genome-wide studies

Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y and Hume, DA (2007) Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews Genetics, 8 6: 424-436. doi:10.1038/nrg2026

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1

Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., Cook, A. D., Himes, S. R., Hamilton, J. A. and Hume, D. A. (2007) Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. Journal of Leukocyte Biology, 82 1: 111-123. doi:10.1189/jlb.1206713

CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway

Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J., Hume, D. A., Stacey, K. J. and Sweet, M. J. (2006) CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. Journal of Immunology, 177 7: 4473-4480.

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006) A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 11: 1921-1923. doi:10.1096/fj.06-5848fje

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice

Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A. and Du, Hong (2006) Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice. American Journal of Pathology, 169 3: 916-926. doi:10.2353/ajpath.2006.051327

Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes"

Hume, David A. (2006) Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes". Journal of Immunology, 177 4: 2035-2035.

Transcriptional network dynamics in macrophage activation

Nilsson, Roland, Bajic, Vladimir B., Suzuki, Harukazu, di Bernardo, Diego, Bjorkegren, Johan, Katayama, Shintaro, Reid, James F., Sweet, Matthew J., Gariboldi, Manuela, Carninci, Piero, Hayashizaki, Yosihide, Hume, David A., Tegner, Jesper and Ravasi, Timothy (2006) Transcriptional network dynamics in macrophage activation. Genomics, 88 2: 133-142. doi:10.1016/j.ygeno.2006.03.022

Mice and men: Their promoter properties

Bajic, Vladimir B., Tan, Sin Lam, Christoffels, Alan, Schonbach, Christian, Lilpovich, Leonard, Yang, Liang, Hofmann, Oliver, Kruger, Adele, Hide, Winston, Kai, Chikatoshi, Kawai, Jun, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2006) Mice and men: Their promoter properties. Plos Genetics, 2 4: 614-626. doi:10.1371/journal.pgen.0020054

Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs

Maeda, Norihiro, Kasukawa,Takeya, Frith, Martin, Aturaliya, Rajith N., Forrest, Alistair R. R., Ravasi,Timothy, Teasdale, Rohan D., Wells, Christine A., Hume,David A. and Hayashizaki,Yoshihide (2006) Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs. PLoS Genetics, 2 4: 498-503. doi:10.1371/journal.pgen.0020062

Alternate transcription of the Toll-like receptor signaling cascade

Wells, C. A., Chalk, A. M., Forrest, A., Taylor, D., Waddell, N., Schroder, K., Himes, S. R., Faulkner, G., Lo, S., Kasukawa, T., Kawaji, H., Kai, C., Kawai, J., Katayama, S., Carninci, P., Hayashizaki, Y., Hume, D. A. and Grimmond, S. M. (2006) Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology, 7 2: R10.1-R10.17. doi:10.1186/gb-2006-7-2-r10

The JNK are important for development and survival of macrophages

Himes, S. Roy, Sester, David P., Ravasi, Timothy, Cronau, Stephen L., Sasmono, Tedjo and Hume, David A. (2006) The JNK are important for development and survival of macrophages. Journal Of Immunology, 176 4: 2219-2228.

An automatable screen for the rapid identification of proteins amenable to refolding

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006) An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 6: 1750-1757. doi:10.1002/pmic.200500056

Apoptotic cell removal in development and tissue homeostasis

Henson, P. M. and Hume, D. A. (2006) Apoptotic cell removal in development and tissue homeostasis. Trends In Immunology, 27 5: 244-250. doi:10.1016/j.it.2006.03.005

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

Brahmachary, M., Schonbach, C., Yang, L., Huang, E. L., Tan, S. L., Chowdhary, R., Krishnan, S. P. T., Lin, C. Y., Hume, D. A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y. and Bajic, V. B. (2006) Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. Bmc Bioinformatics, 7 Supp. 5: Article number S8. doi:10.1186/1471-2105-7-S5-S8

Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase

Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006) Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62 133-135. doi:10.1107/S17443091060000030

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome

Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., Fukuda, S., Ru, K., Frith, M., Gongora, M., Grimmond, S., Hume, D. A., Hayashizaki, Y. and Mattick, J. S. (2006) Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Research, 16 1: 11-19. doi:10.1101/gr.4200206

Focusing in on structural genomics: The University of Queensland structural biology pipeline

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006) Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 6: 281-289. doi:10.1016/j.bioeng.2006.09.002

Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks

Sharma, S. M., Hu, R., Bronisz, A., Meadows, N., Lusby, T., Fletcher, B., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2006) Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks. Critical Reviews In Eukaryotic Gene Expression, 16 3: 253-277.

Genome-wide analysis of mammalian promoter architecture and evolution

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Frith, Martin C., Forrest, Alistair R. R., Ravasi, Timothy, Grimmond, Sean M., Wells, Christine A., Hume, David A. and Hayashizaki, Yoshihide (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics, 38 6: 626-635. doi:10.1038/ng1789

Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

Inoue, Kenji, Kobayashi, Mika, Yano, Kiichiro, Miura, Mai, Izumi, Akashi, Mataki, Chikage, Doi, Takeshi, Hamakubo, Takao, Reid, Patrick C., Hume, David A., Yoshida, Minoru, Aird, William C., Kodama, Tatsuhiko and Minami, Takashi (2006) Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression. Arteriosclerosis Thrombosis And Vascular Biology, 26 12: 2652-2659. doi:10.1161/01.ATV.0000247247.89787.e7

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006) Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 1: 12-20. doi:10.1016/j.gene.2006.02.031

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006) Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 1: 68-73. doi:10.1016/j.pep.2006.05.006

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

Aung, H. T., Schroder, K., Himes, S. R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D. A., Sweet, M. J. and Ravasi, T. (2006) LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Faseb Journal, 20 9: 1315-1327. doi:10.1096/fj.05-5360com

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006) Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 1: 9-16. doi:10.1093/protein/gzi070

Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Wu, Andy C. K., Grondahl, Lisbeth, Jack, Kevin S., Foo, Michelle X., Trau, Matt, Hume, David A. and Cassady, Alan I. (2006) Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Biomaterials, 27 27: 4715-4725. doi:10.1016/j.biomaterials.2006.05.010

Signal integration between IFN gamma and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J. and Hume, D. A. (2006) Signal integration between IFN gamma and TLR signalling pathways in macrophages. Immunobiology, 211 6-8: 511-524. doi:10.1016/j.imbio.2006.05.007

The mononuclear phagocyte system

Hume, D. A. (2006) The mononuclear phagocyte system. Current Opinion In Immunology, 18 1: 49-53. doi:10.1016/j.coi.2005.11.008

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

Cochrane, Anita L., Kett, Michelle M., Samuel, Chrishan S., Campanale, Naomi V., Anderson, Warwick P., Hume, David A., Little, Melissa H., Bertram, John F. and Ricardo, Sharon D. (2005) Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. Journal of The American Society of Nephrology, 16 12: 3623-3630. doi:10.1681/ASN.2004090771

Therapeutic targets in inflammatory disease

Hume, David A. and Fairlie, David P. (2005) Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 25: 2925-2929. doi:10.2174/092986705774462923

The transcriptional landscape of the mammalian genome

The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005) The transcriptional landscape of the mammalian genome. Science, 309 5740: 1559-1563. doi:10.1126/science.1112014

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005) The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 3: 1399-1405.

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005) An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 2: 309-317. doi:10.1016/j.str.2004.12.013

Antisense transcription in the mammalian transcriptome

RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005) Antisense transcription in the mammalian transcriptome. Science, 309 5740: 1564-1566. doi:10.1126/science.1112009

Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides

Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005) Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 2: 605-608.

Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides

Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005) Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 6: 3569-3576.

Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.

Ripoll, V. M., Hume, D. A. and Fontanilla, M.R. (2005) Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.. Biomedica, 25 2: 261-270. doi:10.7705/biomedica.v25i2.1348

Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation

Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005) Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 2: 154-164. doi:10.1016/j.abb.2005.05.013

Inflammation suppressor genes: please switch out all the lights

Wells, C. A., Ravasi, T. and Hume, D. A. (2005) Inflammation suppressor genes: please switch out all the lights. Journal of Leukocyte Biology, 78 1: 9-13. doi:10.1189/jlb.1204710

LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action

Sester, D. P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J. A., McDonald, R. C., Ripoll, V., Wells, C. A., Suzuki, H., Hayashizaki, Y., Stacey, K. J., Hume, D. A. and Sweet, M. J. (2005) LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology, 210 2-4: 97-107. doi:10.1016/j.imbio.2005.05.004

Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing

Raisanen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A. and Vaananen, H. K. (2005) Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing. Biochemical And Biophysical Research Communications, 331 1: 120-126. doi:10.1016/j.bbrc.2005.03.133

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005) Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 2: 327-329. doi:10.1016/j.ab.2005.06.016

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005) Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 1: 13-20. doi:10.1007/s10969-005-0462-7

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., Reynolds, E. C., Hume, D. A., Hamilton, J. A., Geczy, C. L. and Anderson, G. P. (2005) S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 4 1: 136-145. doi:10.1021/pr049829t

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha

Murray, Rachael Z., Wylie, Fiona G., Khromykh, Tatiana, Hume, David A. and Stow, Jennifer L. (2005) Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha. Journal of Biological Chemistry, 280 11: 10478-10483. doi:10.1074/jbc.M414420200

The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages

Himes, S. R., Cronau, S., Mulford, C. and Hume, D. A. (2005) The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene, 24 34: 5278-5286. doi:10.1038/sj.onc.1208657

Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor

Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Sollner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., Hume, D. A. and Andreesen, R. (2005) Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of Immunology, 174 11: 7111-7122.

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible

Tagoh, Hiromi, Schebesta, Alexandra, Lefevre, Pascal, Wilson, Nicola, Hume, David, Busslinger, Meinrad and Bonifer, Constanze (2004) Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. The EMBO Journal, 23 21: 4275-4285. doi:10.1038/sj.emboj.7600421

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 2: 154-162. doi:10.1016/j.abb.2004.01.008

Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis

Kasukawa, T., Katayama, S., Kawaji, H., Suzuki, H., Hume, D. A. and Hayashizaki, Y. (2004) Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis. Genomics, 84 6: 913-921. doi:10.1016/j.ygeno.2004.08.011

Interferon-gamma: an overview of signals, mechanisms and functions

Schroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004) Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 2: 163-189. doi:10.1189/jlb.0603252

Probing the S100 protein family through genomic and functional analysis

Ravasi, Timothy, Hsu, Kenneth, Goyette, Jesse, Schroder, Kate, Yang, Zheng, Rahimi, Farid, Miranda, Les P., Alewood, Paul F., Hume, David A. and Geczy, Carolyn (2004) Probing the S100 protein family through genomic and functional analysis. Genomics, 84 1: 10-22. doi:10.1016/j.ygeno.2004.02.002

Rasputin, more promiscuous than ever: a review of G3BP

Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004) Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 10: 1065-1077. doi:10.1387/ijdb.041893ki

Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection

McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D. and Wainwright, B. (2003) Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infection And Immunity, 71 10: 6035-6044. doi:10.1128/IAI.71.10.6035-6044.2003

Regulation of the murine TRACP gene promoter

Cassady, A. I., Luchin, A., Ostrowski, M. C. and Hume, David A. (2003) Regulation of the murine TRACP gene promoter. Journal of Bone And Mineral Research, 18 10: 1901-1904. doi:10.1359/jbmr.2003.18.10.1901

Genetic control of the innate immune response

Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B. J. and Hume, D. A. (2003) Genetic control of the innate immune response. BMC Immunology, 4 Article 5: 1-18. doi:10.1186/1471-2172-4-5

A guide to the mammalian genome

Okazaki, Y and Hume, DA (2003) A guide to the mammalian genome. Genome Research, 13 6 B: 1267-1272. doi:10.1101/gr.1445603

Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome

Zavolan, M., Kondo, S., Schonbach, C., Adachi, J., Hume, D. A., Hayashizaki, Y., Gaasterland, T., RIKEN GER Grp and GLS Members (2003) Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Research, 13 6B: 1290-1300. doi:10.1101/gr.1017303

Phosphoregulators: Protein kinases and protein phosphatases of mouse

Forrest, Alistair R. R., Ravasi, Timothy, Taylor, Darrin, Huber, Thomas L., Hume, David A., RIKEN GER Group, GSL Members and Grimmond, Sean (2003) Phosphoregulators: Protein kinases and protein phosphatases of mouse. Genome Research, 13 6B: 1443-1454. doi:10.1101/gr.954803

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA

Stacey, Katryn J., Young, Greg R., Clark, Francis, Sester, David P., Roberts, Tara L., Naik, Shalin, Sweet, Matthew J. and Hume, David A. (2003) The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. Journal of Immunology, 170 7: 3614-3620.

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse

Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R. and Hume, D. A. (2003) A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 101 3: 1155-1163. doi:10.1182/blood-2002-02-1569

CSF-1 as a regulator of macrophage activation and immune responses

Sweet, MJ and Hume, DA (2003) CSF-1 as a regulator of macrophage activation and immune responses. Archivum Immunologiae Et Therapiae Experimentalis, 51 3: 169-177.

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage

Wells, C. A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Faulkner, G. J., Okazaki, Y., Quackenbush, J., Hume, D. A., RIKEN GER Group,, GSL Members, and Lyons, P. A. (2003) Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Research, 13 6B: 1360-1365. doi:10.1101/gr.1056103

Development and evaluation of an automated annotation pipeline and cDNA annotation system

Kasukawa, T., Furuno, M., Nikaido, I., Bono, H., Hume, D. A., Bult, C., Hill, D. P., Baldarelli, R., Gough, J., Kanapin, A., Matsuda, H., Schriml, L. M., Hayashizaki, Y., Okazaki, Y. and Quackenbush, J. (2003) Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Research, 13 6B: 1542-1551. doi:10.1101/gr.992803

Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome

Tajul Arifin, K., Teasdale, R. D., Ravasi, T., Hume, D. A., RIKEN GER Group,, GSL Members, and Mattick, J. S. (2003) Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Reaserch, 13 6B: 1416-1429. doi:10.1101/gr.1015703

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection

Numata, K., Kanai, A., Saito, R., Kondo, S., Adachi, J., Wilming, L. G., Hume, D. A., RIKEN GER Group,, GSL Members,, Hayashizaki, Y. and Tomita, M. (2003) Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Research, 13 6B: 1301-1306. doi:10.1101/gr.1011603

Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene

Walsh, N. C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D. A. and Cassady, A. I. (2003) Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene, 307 111-123. doi:10.1016/S0378-1119(03)00449-9

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome

Ravasi, T., Huber, T. L., Zavolan, M., Forrest, A. R., Gaasterland, T., Grimmond, S. M., RIKEN GER Group,, GSL Members, and Hume, D. A. (2003) Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome. Genome Research, 13 6B: 1430-1442. doi:10.1101/gr.949803

The mouse secretome: functional classification of the proteins secreted into the extracellular environment

Grimmond, Sean M., Miranda, Kevin C., Yuan, Zheng, Davis, Melissa J., Hume, David A., Yagi, Ken, Tominaga, Naoko, Bono, Hidemasa, Hayashizaki, Yoshihide, Okazaki, Yasushi, RIKEN GER Group,, GSL Members, and Teasdale, Rohan D. (2003) The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Research, 13 6B: 1350-1359. doi:10.1101/gr.983703

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Teasdale, R. D., Hume, D. A., Yuan, Zheng and The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team (2002) Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420 6915: 563-573. doi:10.1038/nature01266

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities

Oceandy, Delvac, McMorran, Brendan J., Smith, Stephen N., Schreiber, Rainer, Kunzelmann, Karl, Alton, Eric W. F. W., Hume, David A. and Wainwright, Brandon J. (2002) Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics, 11 9: 1059-1067. doi:10.1093/hmg/11.9.1059

NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells

Xie, Y., Chen, C. M., Stevenson, M. A., Hume, D. A., Auron, P. E. and Calderwood, S. K. (2002) NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochemical And Biophysical Research Communications, 291 4: 1071-1080. doi:10.1006/bbrc.2002.6562

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages

Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., Hume, David A. and Liew, Foo Y. (2002) Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. Journal of Immunology, 168 1: 392-399.

Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S. and Hume, D. A. (2002) Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes. Journal of Immunology, 168 1: 44-50.

Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism

Wardrop, S. L., Wells, C., Ravasi, T., Hume, D. A. and Richardson, D. R. (2002) Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism. Journal of Leukocyte Biology, 71 1: 99-106.

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. and Ostrowski, M. C. (2002) The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts. Journal of Leukocyte Biology, 71 2: 295-303.

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter

Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. and Ostrowski, M. C. (2002) The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. Journal of Leukocyte Biology, 71 2: 304-310.

The mononuclear phagocyte system revisited

Hume, David A., Ross, Ian L., Himes, S. Roy, Sasmono, R. Tedjo, Wells, Christine A. and Ravasi, Timothy (2002) The mononuclear phagocyte system revisited. Journal of Leukocyte Biology, 72 4: 621-627.

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells

Tagoh, H., Himes, R., Clarke, D., Leenen, P. J. M., Riggs, A. D., Hume, D. and Bonifer, C. (2002) Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes and Development, 16 13: 1721-1737. doi:10.1101/gad.222002

A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression

Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, T., Oceandy, D., Clark, R., Bonifer, C. and Hume, D. A. (2001) A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. Journal of Leukocyte Biology, 70 5: 812-820.

G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease

Mcmorran, B., Palmer, J., Lunn, D., Oceandy, D., Costelloe, E. O., Thomas, G., Hume, D. A. and Wainwright, B. J. (2001) G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. AJP-Lung Cellular and Molecular Physiology, 281 3: 740-747.

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation

Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2001) Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. Journal of Biological Chemistry, 276 39: 36703-36710. doi:10.1074/jbc.M106418200

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state

Hume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A.O., Liew, F.Y. and Aderem, A. (2001) Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunology, 2 11: 1-12. doi:10.1186/1471-2172-2-11

Structural genomics: Protein structures for the masses?

Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001) Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 2: 13-16.

Transcriptional regulation of c-fms gene expression

Xie, Y., Chen, C. M. and Hume, D. A. (2001) Transcriptional regulation of c-fms gene expression. Cell Biochemistry And Biophysics, 34 1: 1-16. doi:10.1385/CBB:34:1:001

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000) Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 5: 575-584. doi:10.1016/S8756-3282(00)00368-9

G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages

Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000) G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 7: 3870-3877.

Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction

Dwidedi, P. P., Omdahl, J. L., Kola, I., Hume, D. A. and Kay, B. K. (2000) Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction. Journal of Biological Chemistry, 275 1: 47-55. doi:10.1074/jbc.275.1.47

Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene

Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A. and Sester, D. (2000) Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. The FASEB Journal, 15 15: 2393-2395.

How do you see CG

Aderem, A. and Hume, D. A. (2000) How do you see CG. Cell, 103 7: 993-996. doi:10.1016/S0092-8674(00)00201-4

Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.

Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000) Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 4: 427-438. doi:10.1089/107999000312379

Macrophage activation by immunostimulatory DNA

Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000) Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247 41-58.

Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1

Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000) Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 8: 4165-4173.

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000) Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 2: 419-424. doi:10.1016/S0378-1119(00)00305-X

Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor

Fowles, L. F., Stacey, K. J., Marks, D., Hamilton, J. A. and Hume, D. A. (2000) Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochemical Journal, 347 1: 313-320. doi:10.1042/0264-6021:3470313

The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts

Luchin, A., Purdom, G., Murphy, K. M., Clark, M., Angel, N., Cassady, A. I., Hume, D. A. and Ostrowski, M. (2000) The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts. Journal of Bone and Mineral Research, 15 3: 451-460. doi:10.1359/jbmr.2000.15.3.451

Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover

Angel, N., Cahill, M. M., King, A., Ostrowski, M., Cassady, A. I. and Hume, D. A. (2000) Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover. Journal of Bone and Mineral Research, 15 1: 103-110. doi:10.1359/jbmr.2000.15.1.103

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo

Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999) A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 4: 2209-2216.

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999) Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 4: 279-291. doi:10.3109/08977199909069146

Young scientists in biomedical research

Hume, DA (1999) Young scientists in biomedical research. Science, 284 5411: 49-49.

Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members

Rehli, Michael, Den Elzen, Nicole, Cassady, A. Ian, Ostrowski, Michael C. and Hume, David A. (1999) Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics, 56 1: 111-120. doi:10.1006/geno.1998.5588

Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999) Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 12: 6541-6550.

CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages

Kakuda, D. K., Sweet, M. J., MacLeod, C. L., Hume, D. A. and Markovich, D. (1999) CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochemical Journal, 340 2: 549-553. doi:10.1042/0264-6021:3400549

Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide

Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999) Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 3: 528-534.

Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin

Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999) Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 1: 172-183.

The actions of bacterial DNA on murine macrophages

Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999) The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 4: 542-548.

Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling

Fowles, Lindsay F., Martin, Michele L., Nelsen, Lori, Stacey, Katryn J., Redd, Douglas, Clark, Ying Mei, Nagamine, Yoshikune, McMahon, Martin, Hume, David A. and Ostrowski, Michael C. (1998) Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling. Molecular and Cellular Biology, 18 9: 5148-5156. doi:10.1128/MCB.18.9.5148

Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2

D'Orazio, Daniel, Besser, Daniel, Marksitzer, René, Kunz, Christina, Hume, David A., Kiefer, Birgitta and Nagamine, Yoshikuni (1997) Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene, 201 1-2: 179-187. doi:10.1016/S0378-1119(97)00445-9

Effects of CSF-1 on cholesterol accumulation and efflux by macrophages

Jessup, W, Squires, B, Kritharides, L, Hume, DA and Dean, RT (1997) Effects of CSF-1 on cholesterol accumulation and efflux by macrophages. Arteriosclerosis Thrombosis and Vascular Biology, 17 1: 18-25. doi:10.1161/01.ATV.17.1.18

Regulation of CSF-1 receptor expression

Hume, D. A., Yue, X., Ross, I. L., Favot, P., Lichanska, A. and Ostrowski, M. C. (1997) Regulation of CSF-1 receptor expression. Molecular Reproduction and Development, 46 1: 46-53. doi:10.1002/(SICI)1098-2795(199701)46:1<46::AID-MRD8>3.0.CO;2-R

Marketing for leisure and tourism - Morgan,M

Hume, DA (1996) Marketing for leisure and tourism - Morgan,M. Tourism Management, 17 8: 621-621. doi:10.1016/S0261-5177(97)84227-6

Endotoxin signal transduction in macrophages

Sweet, M. J. and Hume, D. A. (1996) Endotoxin signal transduction in macrophages. Journal of Leukocyte Biology, 60 1: 8-26.

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations

Delaney, Stephen J., Alton, Eric W.F.W., Smith, Stephen N., Lunn, Dominic P., Farley, Ray, Lovelock, Paul K., Thomson, Scott A., Hume, David A., Lamb, David, Porteous, David J., Dorin, Julia R. and Wainwright, Brandon J. (1996) Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO Journal, 15 5: 955-963.

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

Yang, Beom-Seok, Hauser, Craig A., Henkel, Gregory, Colman, Michael S., Van Beveren, Charles, Stacey, Katryn J., Hume, David A., Maki, Richard A. and Ostrowski, Michael C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Molecular and Cellular Biology, 16 2: 538-547. doi:10.1128/MCB.16.2.538

Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264

Sweet, M. J. and Hume, D. A. (1996) Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264. Journal of Leukocyte Biology, 59 2: 280-286.

Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines

Favot, P, Yue, X and Hume, DA (1995) Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines. Oncogene, 11 7: 1371-1381.

Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor

Stacey, Katryn J., Fowles, Lindsay F., Colman, Michael S., Ostrowski, Michael C. and Hume, David A. (1995) Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Molecular and Cellular Biology, 15 6: 3430-3441. doi:10.1128/MCB.15.6.3430

RNA synthesis inhibition stabilises urokinase mRNA in macrophages

Stacey, Katryn J., Nagamine, Yoshikuni and Hume, David A. (1994) RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letters, 356 2-3: 311-313. doi:10.1016/0014-5793(94)01294-6

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase

Cassady, AI, King, AG, Cross, Ncp and Hume, DA (1993) Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. Gene, 130 2: 201-207. doi:10.1016/0378-1119(93)90420-8

Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation

Yue, Xie, Favot, Paula, Dunn, Timothy L., Cassady, A. Ian and Hume, David A. (1993) Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Molecular and Cellular Biology, 13 6: 3191-3201. doi:10.1128/MCB.13.6.3191

Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria

Pavli, P, Hume, DA, Vandepol, E and Doe, WF (1993) Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria. Immunology, 78 1: 132-141.

The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin

Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993) The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 3: 392-401. doi:10.1111/j.1365-2141.1993.tb03092.x

Induction of Class-Ii Major Histocompatibility Antigens On Thyroid, Adult Pancreatic-Islet, and Fetal Proislet Allografts

Warren, HS, Hodder, MJ, Allan, W, Hume, DA and Simeonovic, CJ (1992) Induction of Class-Ii Major Histocompatibility Antigens On Thyroid, Adult Pancreatic-Islet, and Fetal Proislet Allografts. Transplantation, 53 4: 834-840. doi:10.1097/00007890-199204000-00025

Involvement of γ‐Aminobutyric Acid and N‐Methyl‐D‐Aspartate Receptors in the Inhibitory Effect of Ethanol on Pentylenetetrazole‐Induced c‐fos Expression in Rat Brain

Le, F, Wilce, PA, Hume, DA and Shanley, BC (1992) Involvement of γ‐Aminobutyric Acid and N‐Methyl‐D‐Aspartate Receptors in the Inhibitory Effect of Ethanol on Pentylenetetrazole‐Induced c‐fos Expression in Rat Brain. Journal of Neurochemistry, 59 4: 1309-1315. doi:10.1111/j.1471-4159.1992.tb08442.x

Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication

Todd, B., Pope, J. H., Ross, I. L. and Hume, D. A. (1992) Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication. Journal of Virological Diseases, 1 24-33.

The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice

Hume D.A. and Denkins Y. (1992) The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine and Cytokine Research, 11 2: 95-98.

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991) Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 24: 6839-6847. doi:10.1093/nar/19.24.6839

Interactions Among Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Ifn-Gamma Lead to Enhanced Proliferation of Murine Macrophage Progenitor Cells

Breen, FN, Hume, DA and Weidemann, MJ (1991) Interactions Among Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Ifn-Gamma Lead to Enhanced Proliferation of Murine Macrophage Progenitor Cells. Journal of Immunology, 147 5: 1542-1547.

Isolation and Characterization of Antigen-Presenting Dendritic Cells From the Mouse Intestinal Lamina Propria

Pavli, P, Woodhams, CE, Doe, WF and Hume, DA (1990) Isolation and Characterization of Antigen-Presenting Dendritic Cells From the Mouse Intestinal Lamina Propria. Immunology, 70 1: 40-47.

Immunopathological Investigations During the Course of Arthritis Induced in Rats by Streptococcus-Agalactiae

Abd, Aha, Hume, DA, Halliday, WJ and Davis, Ghg (1990) Immunopathological Investigations During the Course of Arthritis Induced in Rats by Streptococcus-Agalactiae. Medical Microbiology and Immunology, 179 1: 13-23.

The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture

Breen, FN, Hume, DA and Weidemann, MJ (1990) The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture. British Journal of Haematology, 74 2: 138-145. doi:10.1111/j.1365-2141.1990.tb02556.x

Encapsulation Is Not Involved in the Activities of Recombinant Gamma-Interferon Associated with Multilamellar Phospholipid Liposomes On Murine Bone Marrow-Derived Macrophages

Hume, DA and Nayar, R (1989) Encapsulation Is Not Involved in the Activities of Recombinant Gamma-Interferon Associated with Multilamellar Phospholipid Liposomes On Murine Bone Marrow-Derived Macrophages. Lymphokine Research, 8 4: 415-425.

The Therapeutic Effect of Human Recombinant Macrophage Colony Stimulating Factor (Csf-1) in Experimental Murine Metastatic Melanoma

Hume, DA, Donahue, RE and Fidler, IJ (1989) The Therapeutic Effect of Human Recombinant Macrophage Colony Stimulating Factor (Csf-1) in Experimental Murine Metastatic Melanoma. Lymphokine Research, 8 1: 69-77.

Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction

Hume D.A. and Denkins Y.M. (1989) Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction. Immunology and Cell Biology, 67 4: 243-249.

The Effect of Human Recombinant Macrophage Colony-Stimulating Factor (Csf-1) On the Murine Mononuclear Phagocyte System Invivo

Hume, DA, Pavli, P, Donahue, RE and Fidler, IJ (1988) The Effect of Human Recombinant Macrophage Colony-Stimulating Factor (Csf-1) On the Murine Mononuclear Phagocyte System Invivo. Journal of Immunology, 141 10: 3405-3409.

Macrophage infiltration into experimental brain metastases: Occurrence through an intact blood-brain barrier

Schackert, G, Simmons, RD, Buzbee, TM, Hume, DA and Fidler, IJ (1988) Macrophage infiltration into experimental brain metastases: Occurrence through an intact blood-brain barrier. Journal of the National Cancer Institute, 80 13: 1027-1034. doi:10.1093/jnci/80.13.1027

Antigenic Variation and Macrophage Infiltration of Human Bladder-Tumors Xenografted Into Nude-Mice

Russell, PJ, Philips, J, Allan, W and Hume, DA (1988) Antigenic Variation and Macrophage Infiltration of Human Bladder-Tumors Xenografted Into Nude-Mice. Journal of Leukocyte Biology, 43 4: 335-342.

Role of Ia-Positive Leukocytes and F4/80-Positive Macrophages in the Immunogenicity of Fetal Mouse Proislets and Fetal Pancreas

Simeonovic, CJ, Hodder, MJ and Hume, DA (1988) Role of Ia-Positive Leukocytes and F4/80-Positive Macrophages in the Immunogenicity of Fetal Mouse Proislets and Fetal Pancreas. Transplantation Proceedings, 20 1: 68-71.

Immunohistochemical Characterization of Macrophages in Human-Liver and Gastrointestinal-Tract - Expression of Cd4, Hla-Dr, Okm1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1987) Immunohistochemical Characterization of Macrophages in Human-Liver and Gastrointestinal-Tract - Expression of Cd4, Hla-Dr, Okm1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue. Journal of Leukocyte Biology, 42 5: 474-484.

Growth-Regulation in Murine Bone Marrow-Derived Macrophages - Effects of Contaminating Endotoxin in Commercial Gm-Csf and Interleukin-4

Hume, DA (1987) Growth-Regulation in Murine Bone Marrow-Derived Macrophages - Effects of Contaminating Endotoxin in Commercial Gm-Csf and Interleukin-4. Lymphokine Research, 6 4: 357-359.

Regulation of Proliferation of Bone Marrow-Derived Macrophages

Hume, DA, Allan, W, Fabrus, B, Weidemann, MJ, Hapel, AJ and Bartelmez, S (1987) Regulation of Proliferation of Bone Marrow-Derived Macrophages. Lymphokine Research, 6 2: 127-139.

Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells

Warren, HS, Simeonovic, CJ, Allan, W and Hume, DA (1987) Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells. Transplantation Proceedings, 19 1: 213-213.

Immunohistochemical Analysis of the Involvement of F4/80 and Ia-Positive Macrophages in Mouse-Liver Infected with Lymphocytic Choriomeningitis Virus

Dixon, JE, Allan, JE, Doherty, PC and Hume, DA (1986) Immunohistochemical Analysis of the Involvement of F4/80 and Ia-Positive Macrophages in Mouse-Liver Infected with Lymphocytic Choriomeningitis Virus. Journal of Leukocyte Biology, 40 5: 617-628.

Localization and Function of Tissue Macrophages

Gordon, S, Crocker, PR, Morris, L, Lee, SH, Perry, VH and Hume, DA (1986) Localization and Function of Tissue Macrophages. Ciba Foundation Symposia, 118 54-67. doi:10.1002/9780470720998.ch5

Expression of 20-Alpha-Hydroxysteroid Dehydrogenase in Mouse Macrophages, Hematopoietic-Cells, and Cell-Lines and its Induction by Colony-Stimulating Factors

Hapel, AJ, Osborne, JM, Fung, MC, Young, IG, Allan, W and Hume, DA (1985) Expression of 20-Alpha-Hydroxysteroid Dehydrogenase in Mouse Macrophages, Hematopoietic-Cells, and Cell-Lines and its Induction by Colony-Stimulating Factors. Journal of Immunology, 134 4: 2492-2497.

Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines

Summers, KM and Hume, DA (1985) Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines. Lymphokine Research, 4 3: 229-235.

Immunohistochemical Analysis of Murine Mononuclear Phagocytes that Express Class II Major Histocompatibility Antigens

Hume, DA (1985) Immunohistochemical Analysis of Murine Mononuclear Phagocytes that Express Class II Major Histocompatibility Antigens. Immunobiology, 170 5: 381-389. doi:10.1016/S0171-2985(85)80062-0

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, VH, Hume, DA and Gordon, S (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience, 15 2: 313-326. doi:10.1016/0306-4522(85)90215-5

Minactivin Expression in Human Monocyte and Macrophage Populations

Stephens, RW, Golder, JP, Fayle, Drh, Hume, DA, Hapel, AJ, Allan, W, Fordham, CJ and Doe, WF (1985) Minactivin Expression in Human Monocyte and Macrophage Populations. Blood, 66 2: 333-337.

Preparation and Characterization of Human-Bone Marrow-Derived Macrophages

Hume, DA, Allan, W, Golder, J, Stephens, RW, Doe, WF and Warren, HS (1985) Preparation and Characterization of Human-Bone Marrow-Derived Macrophages. Journal of Leukocyte Biology, 38 4: 541-552.

Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines

Hume, DA, Summers, KM, Cohen, DR and Allan, W (1985) Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines. Febs Letters, 180 2: 271-274. doi:10.1016/0014-5793(85)81084-X

Different Colon-Stimulating Factors Are Detected by the Interleukin-3 Dependent Cell-Lines Fdc-Pl and 32D Cl-23

Hapel, AJ, Warren, HS and Hume, DA (1984) Different Colon-Stimulating Factors Are Detected by the Interleukin-3 Dependent Cell-Lines Fdc-Pl and 32D Cl-23. Blood, 64 4: 786-790.

The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages. Opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E

Hume, DA and Gordon, S (1984) The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages. Opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E. Experimental Cell Research, 150 2: 347-355. doi:10.1016/0014-4827(84)90578-0

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: Macrophages associated with epithelia

Hume, DA, Perry, VH and Gordon, S (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: Macrophages associated with epithelia. Anatomical Record, 210 3: 503-512. doi:10.1002/ar.1092100311

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs

Hume, DA, Robinson, AP, Macpherson, GG and Gordon, S (1983) The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. Journal of Experimental Medicine, 158 5: 1522-1536. doi:10.1084/jem.158.5.1522

The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages. An electron paramagnetic resonance study of the response to phorbol myristate acetate

Hume, DA, Gordon, S, Thornalley, PJ and Bannister, JV (1983) The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages. An electron paramagnetic resonance study of the response to phorbol myristate acetate. Biochimica Et Biophysica Acta, 763 3: 245-250. doi:10.1016/0167-4889(83)90131-3

Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex

Hume, DA and Gordon, S (1983) Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. Journal of Experimental Medicine, 157 5: 1704-1709. doi:10.1084/jem.157.5.1704

Immunohistochemical Localization of a Macrophage-Specific Antigen in Developing Mouse Retina - Phagocytosis of Dying Neurons and Differentiation of Microglial Cells to Form a Regular Array in the Plexiform Layers

Hume, DA, Perry, VH and Gordon, S (1983) Immunohistochemical Localization of a Macrophage-Specific Antigen in Developing Mouse Retina - Phagocytosis of Dying Neurons and Differentiation of Microglial Cells to Form a Regular Array in the Plexiform Layers. Journal of Cell Biology, 97 1: 253-257. doi:10.1083/jcb.97.1.253

Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: The roles of CSF‐1, serum, Ca2+, and adherence

Hume, DA and Gordon, S (1983) Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: The roles of CSF‐1, serum, Ca2+, and adherence. Journal of Cellular Physiology, 117 2: 189-194. doi:10.1002/jcp.1041170209

Urinary hormone levels: A population study of associations between steroid and catecholamine excretion rates

Summers, KM, Harrison, GA, Hume, DA and Palmer, CD (1983) Urinary hormone levels: A population study of associations between steroid and catecholamine excretion rates. Annals of Human Biology, 10 2: 99-110. doi:10.1080/03014468300006241

Regulation of Bone-Marrow Macrophage Proliferation

Hume, DA and Gordon, S (1982) Regulation of Bone-Marrow Macrophage Proliferation. Advances in Experimental Medicine and Biology, 155 261-266.

Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis

Hume, DA, Wrogemann, K, Ferber, E, Kolbuchbraddon, ME, Taylor, RM, Fischer, H and Weidemann, MJ (1981) Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis. Biochemical Journal, 198 3: 661-667. doi:10.1042/bj1980661

Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport

Hume, DA, Weidemann, MJ and Ferber, E (1979) Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport. Journal of the National Cancer Institute, 62 5: 1243-1246.

Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

Hume, DA, Thornton, MR, Weidemann, MJ and Speth, V (1979) Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli. Journal of Cellular Physiology, 101 3: 523-528. doi:10.1002/jcp.1041010318

Role and Regulation of Glucose-Metabolism in Proliferating Cells

Hume, DA and Weidemann, MJ (1979) Role and Regulation of Glucose-Metabolism in Proliferating Cells. Journal of the National Cancer Institute, 62 1: 3-3.

Aerobic glycolysis and lymphocyte transformation

Hume, DA, Radik, JL, Ferber, E and Weidemann, MJ (1978) Aerobic glycolysis and lymphocyte transformation. Biochemical Journal, 174 3: 703-709. doi:10.1042/bj1740703

Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport

Hume, DA, Hansen, K, Weidemann, MJ and Ferber, E (1978) Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport. Nature, 272 5651: 359-359. doi:10.1038/272359a0

Effect of Nh4 and Ca2+ On Gluconeogenesis From Lactate by Isolated Rat Hepatocytes

Hume, DA and Weidemann, MJ (1978) Effect of Nh4 and Ca2+ On Gluconeogenesis From Lactate by Isolated Rat Hepatocytes. Hormone and Metabolic Research, 10 5: 449-450. doi:10.1055/s-0028-1095840

On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli

Hume, DA and Weidemann, MJ (1978) On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli. Journal of Cellular Physiology, 96 3: 303-308. doi:10.1002/jcp.1040960305

The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens

Hume, DA, Vijayakumar, EK, Schweinberger, F, Russell, LM and Weidemann, MJ (1978) The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens. Biochemical Journal, 174 3: 711-716. doi:10.1042/bj1740711

Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide

Yasmeen, D, Laird, AJ, Hume, DA and Weidemann, MJ (1977) Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide. Biochimica Et Biophysica Acta, 500 1: 89-102. doi:10.1016/0304-4165(77)90049-6

Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation

Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. In: International Congress of Immunology (ICI), Melbourne, VIC, Australia, (762-762). 21-26 August 2016. doi:10.1002/eji.201670200

Cross species reactivity of Interleukin 34 (IL-34)

Gow, D. J., Garceau, V., Sester, D. and Hume, D. A. (2012). Cross species reactivity of Interleukin 34 (IL-34). In: Immunology. European Congress of Immunology, Glasgow Scotland, (265-265). Sep 05-08, 2012.

The production of porcine anti-CSF-1R antibodies: reagents to evaluate the effects of CSF-1 on postnatal growth

Gow, D. J., Garceau, V., Moffat, L., Kapetanovic, R., Sester, D. and Hume, D. A. (2012). The production of porcine anti-CSF-1R antibodies: reagents to evaluate the effects of CSF-1 on postnatal growth. In: Immunology. European Congress of Immunology, Glasgow Scotland, (653-653). Sep 05-08, 2012.

Gene targeting of the rat Csf1r locus using homologous recombination in ES cells

Upton, Kyle R., Pridans, Clare, Meek, Stephen, Sutherland, Linda, Whitelaw, Bruce, Burdon, Tom and Hume, David (2011). Gene targeting of the rat Csf1r locus using homologous recombination in ES cells. In: 10th Transgenic Technology Meeting (TT2011), Florida, United States, (1160-1160). 24-26 October 2011. doi:10.1007/s11248-011-9540-8

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

Forrest, A. R. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., de Hoon, M. J. L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. In: Differentiation. , , (S31-S31). . doi:10.1016/j.diff.2010.09.048

Docosahexaenoic acid (22:6n-3) protects from early retinal degeneration and attenuates microglial activation

Ebert, Stefanie, Weigelt, Karin, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009). Docosahexaenoic acid (22:6n-3) protects from early retinal degeneration and attenuates microglial activation. In: Chemistry and Physics of Lipids. 50th International Conference on Bioscience of Lipids, Regenburg Germany, (S25-S26). Sep 01-05, 2009. doi:10.1016/j.chemphyslip.2009.06.022

Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing

Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. In: Journal of Bone and Mineral Research. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, (). 11-15 September, 2009.

Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth

Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, Sharon D. (2008). Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth. In: Nephrology. , , (A118-A118). .

Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation

Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. In: Abstracts of the 35th European Symposium on Calcified Tissues. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, (S98-S99). 24-28 May 2008. doi:10.1007/s00223-008-9118-5

Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization

Alexander, K. A., Chang, M. K., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoli, V. M. and Schroder, K. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization. In: Calcified Tissue International. 35th European Symposium on Calcified Tissues, Barcelona, Spain, (S98-S99). 24-28 May 2008. doi:10.1007/s00223-008-9118-5

Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice

Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, S. D. (2007). Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice. In: Nephrology. , , (A13-A13). .

Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model

Ricardo, S. D., Alikhan, M. A., Campanale, N. V., Hume, D. A. and Little, M. H. (2007). Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model. In: Nephrology. , , (A16-A16). .

Osteal Macrophages: Novel regulators of Bone Formation

Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. In: Journal of Bone and Mineral Research: 29th Annual Meeting of the American Society for Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, (s53-s53). 16th -19th September, 2007.

Osteal macrophages: Novel regulators of bone formation

Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. In: Journal of Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, United States, (S53-S53). 16-19 September 2007.

The Jun N-terminal kinases are important for the survival and development of macrophages

Sester, D. P., Hines, S. R., Ravasi, T., Cronau, S. L., Sasmono, T. and Hume, D. A. (2007). The Jun N-terminal kinases are important for the survival and development of macrophages. In: Immunology. Annual Congress of the British-Society-of-Immunology, Glasgow Scotland, (83-83). Feb 20-23, 2007.

The endosteal bone niche contains macrophages that regulate osteoblast function

Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. In: Bone. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, (S127-S127). 24-29 June 2007. doi:10.1016/j.bone.2007.04.166

Structure and function of mammalian fibrillin genes

Summers, K and Hume, D A (2006). Structure and function of mammalian fibrillin genes. In: 11th International Congress of Human Genetics. 11th International Congress of Human Genetics, Brisbane, (Abstract). 6-10 Aug, 2006.

T cells are the source of GM-CSF required for collagen-induced arthritis induction.

Cook, Andrew D., Tumer, Amanda L., Braine, Emma L., Hume, David A. and Hamilton, John A. (2006). T cells are the source of GM-CSF required for collagen-induced arthritis induction.. In: Arthritis and Rheumatism. 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Washington Dc, (S593-S593). Nov 10-15, 2006.

The use of transgenes to study macrophage differentiation and function

Hume, D. A. (2006). The use of transgenes to study macrophage differentiation and function. In: Bruce Whitelaw and Paul Christou, Program and Abstracts of the 7th Transgenic Technology Meeting (TT2007). 7th Transgenic Technology Meeting (TT2007), St Lucia, Brisbane, Australia, (778-779). 12-14 February 2007. doi:10.1007/s11248-006-9047-x

PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages

Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. In: Inflammation Research. , , (S186-S187). .

Beta-arrestin expression and function in macrophages

Lattin, Jane E., Blomberg, Lovisa M., Daly, Norelle L., Craik, David J., Robinson, Jodie A., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2005). Beta-arrestin expression and function in macrophages. In: Inflammation 2005: Book of Abstracts. 7th World Congress on Inflammation: Inflammation 2005: Inflammation, the Key to much pathology, Melbourne, Australia, (S157-S158). 20 - 24 August 2005.

Blockade of CSF-1 action enhances CpG DNA responses in vivo

Trieu, Angela, Cronau, Steve, Roberts, Tara, Lottin, Jane, Vlahos, Ross, Stacey, Katryn J., Hume, David A. and Sweet, Matthew J. (2005). Blockade of CSF-1 action enhances CpG DNA responses in vivo. In: Inflammation Research. , , (S191-S191). .

Novel macrophage-restricted gene involved in inflammation

Ripoll, Vera M., Ravasi, Timothy and Hume, David A. (2005). Novel macrophage-restricted gene involved in inflammation. In: Inflammation Research. , , (S143-S143). .

Purified splenic B-cells do not respond to E. coli DNA

Roberts, Tara L., Dann, Jasmyn A., Sweet, Matthew J., Hume, David A., Lenert, Petar and Stacey, Katryn J. (2005). Purified splenic B-cells do not respond to E. coli DNA. In: Inflammation Research. , , (S186-S186). .

Regulation and function of toll-like receptor 9 in macrophages

Sweet, Matthew J., Schroder, Kate, Sester, David P., Trieu, Angela, Rehli, Michael, Risvanathan, Kumar, Stacey, Katryn J. and Hume, David A. (2005). Regulation and function of toll-like receptor 9 in macrophages. In: Inflammation Research. , , (S186-S186). .

Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS

Hume, David A., Ravasi, Timothy and Wells, Christine (2004). Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS. In: 1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), Budapest, Hungary, (330-330). 3-7 October 2004. doi:10.1111/j.1399-0039.2004.00315.x

Clues to interaction between CSF-1 and CSF-1R from specificity and structure

Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. In: Australian Society of Immunologists Meeting. Australian Society of Immunologists Meeting, Brisbane, ((Poster)). 1-5 December, 2002.

Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.

Saleh, H, Walsh, N, Ravasi, T, Wells, C, Okazaki, Y, Carninci, P, Hayashizaki, Y, Hume, DA and Cassady, AI (2002). Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.. In: Journal of Bone and Mineral Research. 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, San Antonio Texas, (S348-S348). Sep 20-24, 2002.

Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer

Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. In: International Conference on Structural Genomics. International Conference on Structural Genomics, Berlin, ((Abstract)). 10-13 October, 2002.

Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. In: ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, (). 29 September -3 October, 2002.

Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. In: Australian Society for Immunology Meeting. Australian Society for Immunology Meeting, Brisbane, ((Abstract)). 1-5 December, 2002.

Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides

Pickering, D., Hume, D. A. and Young, P. R. (2001). Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides. In: 6th International Symposium on Positive Strand Viruses, Paris, France, ((Abstract)). 28 May - 2 June, 2001.

Multiple promoters regulate differential expression of murine tartrate resistant acid phosphatase (TRAP).

Walsh, NC, Hume, DA and Cassady, AI (2001). Multiple promoters regulate differential expression of murine tartrate resistant acid phosphatase (TRAP).. In: Journal of Bone and Mineral Research. , , (S379-S379). .

Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.

Cassady, AI, Merson, T, Suchting, S, Hong, TW and Hume, DA (2000). Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.. In: Journal of Bone and Mineral Research. , , (S280-S280). .

Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.

Luchin, AI, Cassady, AI, Hume, DA and Ostrowski, MC (2000). Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.. In: Molecular Biology of the Cell. , , (163A-163A). .

Replication protein A binds preferentially to immunostimulatory oligonucleotides.

Stacey, KJ, Sester, DP, Murphy, KM, Sweet, MJ and Hume, DA (2000). Replication protein A binds preferentially to immunostimulatory oligonucleotides.. In: Faseb Journal. , , (A1049-A1049). .

An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages

Himes, S. R., Goonetilleke, N. P. and Hume, D. A. (1999). An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-11-04). 27-30 September, 1999.

CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. In: Innate Resistant to Infection, Society for Leukocyte Biology. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, (). 22-26 September, 1999.

Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-05-01). 27-30 September, 1999.

Crystallisation of a mammalian purple acid phosphatase

Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. In: 24th Annual Lorne Conference on Protein Structure and Function. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., (C10). 7-11 February, 1999.

ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice

Ostrowski, M., Erbe, L. S., Hume, D. A. and Smith, J. L. (1999). ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice. In: Combined Conference Abstratcs: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-55-01). 27-30 September, 1999.

Immunostimulatory DNA promotes factor independent survival of macrophages

Sester, D. P., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). Immunostimulatory DNA promotes factor independent survival of macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-45-04). 27-30 September, 1999.

Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse

Walsh, N., Angel, N., Williams, E. A., Cassady, A. I. and Hume, D. A. (1999). Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-04-05). 27-30 September, 1999.

Post-Golgi trafficking of TNF-a in macrophages

Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-13-05). 27-30 September 1999.

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Suchting, S. J., Merson, T. D., Angel, N., Cassady, A. I. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Mon-74). 27th - 30th September, 1999.

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Cassady, A. I., Suchting, S. J., Angel, N., Merson, T. D. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. In: Journal of Bone and Mineral Research. 21st Annual Meeting of the ASBMR, St Louis, USA, (S244). 30 Sept - 4 Oct, 1999.

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

Cassady, A. I., Walsh, N., Angel, N., Cahill, M. M., Forwood, M. R., Ostrowski, M. and Hume, D. A. (1999). Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. In: Australian and New Zealand Bone and Mineral Society Conference. 9th Annual Scientific Meeting ANZBMS, Cairns, (). 30 June - 2 July, 1999.

Activation of macrophages by bacterial DNA

Stacey, KJ, Sweet, M and Hume, DA (1996). Activation of macrophages by bacterial DNA. In: Journal of Leukocyte Biology. , , (108-108). .

Molecular-Biology of Macrophage Differentiation

Hume, DA (1993). Molecular-Biology of Macrophage Differentiation. In: Journal of Leukocyte Biology. , , (131-131). .

Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester

Stacey, KJ, Fowles, LF, Coleman, MS, Ostrowski, M and Hume, DA (1993). Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester. In: Journal of Leukocyte Biology. , , (63-63). .

Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression

Favot, P, Fidler, IJ and Hume, DA (1993). Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression. In: Journal of Leukocyte Biology. , , (89-89). .

Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine

Pavli, P, Doe, WF and Hume, DA (1988). Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine. In: Gastroenterology. , , (A346-A346). .

Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages

Pavli, P, Doe, WF and Hume, DA (1987). Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages. In: Gastroenterology. , , (1569-1569). .

Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection

Dixon, JE, Allan, JE, Ceredig, R, Hume, DA and Doherty, PC (1986). Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection. In: Australian and New Zealand Journal of Medicine. , , (150-150). .

Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1986). Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9. In: Gastroenterology. , , (1469-1469). .

The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1985). The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract. In: Australian and New Zealand Journal of Medicine. , , (546-546). .

Assays for Interleukin-3 (Multi-Csf) Are Not Specific

Hapel, AJ, Warren, HS, Hume, DA, Allan, W and Osborne, JM (1984). Assays for Interleukin-3 (Multi-Csf) Are Not Specific. In: Lymphokine Research. , , (248-248). .

Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues

Hume, DA and Gordon, S (1983). Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues. In: Proceedings of the Australian Biochemical Society. , , (97-97). .

Effect of Sulfhydryl Blockage On Stimulation of Thymocyte Glucose-Transport by Concanavalin-A and Ionophore-A23187

Hume, DA and Weidemann, MJ (1977). Effect of Sulfhydryl Blockage On Stimulation of Thymocyte Glucose-Transport by Concanavalin-A and Ionophore-A23187. In: Proceedings of the Australian Biochemical Society. , , (43-43). .

Mitogenic Stimulation of Thymocyte Glucose-Transport Alters Sensitivity of Glucose Carrier to N-Ethylmaleimide and Phloretin

Hume, DA and Weidemann, MJ (1977). Mitogenic Stimulation of Thymocyte Glucose-Transport Alters Sensitivity of Glucose Carrier to N-Ethylmaleimide and Phloretin. In: Hoppe-Seylers Zeitschrift Fur Physiologische Chemie. , , (1223-1223). .