The University of Queensland

A general target selection method for crystallographic proteomics

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. In Kobe, B., Guss, M. and Huber, T.L. (Ed.), Structural Proteomics: High-Throughput Methods 1st ed. (pp. 27-35) Totowa, NJ, USA: Humana Press.

A medium or high throughput protein refolding assay

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. In Bostjan Kobe, Mitchell Guss and Thomas Huber (Ed.), Structural Proteomics: High throughput Methods (pp. 269-275) USA: Humana Press.

Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. In B. Kobe, M. Guss and T. L. Huber (Ed.), Structural proteomics: High-throughput methods (pp. 577-587) Totowa, N.J.: Humana Press.

Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. In Bostjan Kobe, Mitchell Guss and Thomas L. Huber (Ed.), Structural Proteomics: High Throughput Methods 1 ed. (pp. 459-474) Totowa, NJ, USA: Humana Press.

Noncoding RNA's in mammals

Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. In Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam (Ed.), Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics (pp. xx-xx) USA: John Wiley & Sons, Inc.. doi:10.1002/047001153X.g203204

The Biology of Macrophages

Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. In Kaufmann, SE.; Medzhitov, R.; Gordon and S. (Ed.), The Innate Immune Response to Infection (pp. 71-94) Washington, DC, USA: ASM Press.

The regulation of urokinase plasminogen activator gene expression in macrophages

Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. In van Furth, R. (Ed.), Mononuclear Phagocytes: Biology of Monocytes and Macrophages (pp. 233-240) Dordrecht , Netherlands: Kluwer Academic Publishers. doi:10.1007/978-94-015-8070-0

Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016) Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 1: 7-16. doi:10.1038/icb.2016.74

Comparative transcriptome analysis of equine alveolar macrophages

Karagianni, A. E., Kapetanovic, R., Summers, K. M., Mcgorum, B. C., Hume, D. A. and Pirie, R. S. (2016) Comparative transcriptome analysis of equine alveolar macrophages. Equine Veterinary Journal, 49 3: 375-382. doi:10.1111/evj.12584

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015) Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 304: 1-10. doi:10.1126/scitranslmed.aaa3863

Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli

Dave, Richa K., Dinger, Marcel E., Andrew, Megan, Askarian-Amiri, Marjan, Hume, David A. and Kellie, Stuart (2013) Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli. PLoS One, 8 6: e68306.1-e68306.13. doi:10.1371/journal.pone.0068306

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012) Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 16: E944-E953. doi:10.1073/pnas.1110156109

Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide

Kapetanovic, Ronan, Fairbairn, Lynsey, Beraldi, Dario, Sester, David P., Archibald, Alan L., Tuggle, Christopher K. and Hume, David A. (2012) Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. The Journal of Immunology, 188 7: 3382-3394. doi:10.4049/jimmunol.1102649

Somatic retrotransposition alters the genetic landscape of the human brain

Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan. Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A. and Faulkner, Geoffrey J. (2011) Somatic retrotransposition alters the genetic landscape of the human brain. Nature, 479 7374: 534-537. doi:10.1038/nature10531

Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011) Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 7: 1517-1532. doi:10.1002/jbmr.354

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011) Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 1: e15723-1-e15723-13. doi:10.1371/journal.pone.0015723

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010) The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 14: 2295-2302. doi:10.1016/j.molimm.2010.05.289

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010) Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 6: 1103-1114. doi:10.1189/jlb.0509363

A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice

Ovchinnikov, Dmitry A., DeBats, Claire E. E., Sester, David P., Sweet, Matthew J. and Hume, David A. (2010) A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. Journal of Leukocyte Biology, 87 5: 815-822. doi:10.1189/jlb.0809557

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase

Weber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010) Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 2: 447-454. doi:10.1016/j.ejmech.2009.10.025

Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response

Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010) Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 1: 369-380. doi:10.2353/ajpath.2010.090545

Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling

Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009) Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 3: 326-337. doi:10.1111/j.1365-2567.2008.02979.x

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

Dave, R. K., Hume, D. A., Elsegood, C and Kellie, S (2009) CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Experimental Cell Research, 315 10: 1734-1744. doi:10.1016/j.yexcr.2009.02.023

TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium

Trieu, Angela, Bokil, Nilesh, Dunn, Jasmyn A., Roberts, Tara L., Xu, Damo, Liew, Foo Y., Hume, David A., Stacey, Katryn J. and Sweet, Matthew J. (2009) TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium. Immunology and Cell Biology, 87 3: 218-225. doi:10.1038/icb.2008.95

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 5917: 1057-1060. doi:10.1126/science.1169841

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009) Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 2: 278-288. doi:10.1189/jlb.0808497

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?

Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 1-8. doi:10.1186/1756-0500-1-78

Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry

King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008) Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 13: 5036-5043. doi:10.1021/ac702277q

Cortactin adopts a globular conformation and bundles actin into sheets

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008) Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 23: 16187-16193. doi:10.1074/jbc.M708917200

The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

WellsChristineA, Salvage-JonesJudithA, LiXin, HitchensKelly, ButcherSuzanne, MurrayRachaelZ, Beckhouse, Anthony G., LoYu-Lan-Sandra, ManzaneroSilvia, CobboldChristian, SchroderKate, MaBo, OrrSally, StewartLauren, LebusDaniel, SobieszczukPeter, HumeDavidA, StowJennifer, BlanchardHelen, AshmanRobertB, RRich and MHogan (2008) The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology, 180 11: 7404-7413.

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene

Hume, David A., Sasmono, Tedjo, Himes, S. Roy, Sharma, Sudarshana M., Bronisz, Agnieszka, Constantin, Myrna, Ostrowski, Michael C. and Ross, Ian L. (2008) The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. The Journal of Immunology, 180 10: 6733-6742.

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo

Chang, Ming K., Raggatt, Liza-Jane, Alexander, Kylie A., Kuliwaba, Julia S., Fazzalari, Nicola L., Schroder, Kate, Maylin, Erin R., Ripoll, Vera M, Hume, David A. and Pettit, Allison R. (2008) Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo. The Journal of Immunology, 181 2: 1232-1244.

Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity

Lang, P., Van Harmelen, V., Kaaman, M., Parini, P., Carneheim, C., Cassady, A. I., Hume, D. A., Andersson, G. and Arner, P. (2008) Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS One, 3 3: e1713-e1713. doi:10.1371/journal.pone.0001713

Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice

Ovchinnikov, Dmitry A., van Zuylen, Wendy J. M., DeBats, Claire E. E., Alexander, Kylie A., Kellie, Stuart and Hume, David A. (2008) Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. Journal of Leukocyte Biology, 83 2: 430-433. doi:10.1189/jlb.0807585

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

McMorran, Brendan J., Patat, Severine A. Ouvry, Carlin, John B., Grimwood, Keith, Jones, Alun, Armstrong, David S., Galati, John C., Cooper, Peter J., Byrnes, Catherine A., Francis, Paul W., Robertson, Colin F., Hume, David A., Borchers, Christoph H., Wainwright, Claire E. and Wainwright, Brandon J. (2007) Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53 10: 1782-1791. doi:10.1373/clinchem.2007.087650

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages

Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007) Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 6: 3495-3503.

G-protein-coupled receptor expression, function, and signaling in macrophages

Lattin, J., Zidar, D., Schroder, K., Kellie, S., Hume, D. and Sweet, M. (2007) G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology, 82 1: 16-32. doi:10.1189/jlb.0107051

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007) Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 25: 10382-10387. doi:10.1073/pnas.0700974104

The role of schlafen in macrophages and inflammation

van Zuijlen, WJM, Cook, AD, Ovchinnikov, DA, Kellie, S and Hume, DA (2007) The role of schlafen in macrophages and inflammation. Inflammation Research, 56 S389-S389.

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages

Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007) PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 6: 1577-1590. doi:10.1189/jlb.0107036

Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses

Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 10: 6557-6566.

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor

Meadows, Nicholas A., Sharma, Sudarshana M., Faulkner, Geoffrey J., Ostrowski, Michael C., Hume, David A. and Cassady, Alan I. (2007) The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. Journal of Biological Chemistry, 282 3: 1891-1904. doi:10.1074/jbc.M608572200

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

Rae, Fiona, Woods, Kyra, Sasmono, Tedjo, Campanale, Naomi, Taylor, Darrin, Ovchinnikov, Dmitry A., Grimmond, Sean M., Hume, David A., Ricardo, Sharon D. and Little, Melissa H. (2007) Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Developmental Biology, 308 1: 232-246. doi:10.1016/j.ydbio.2007.05.027

Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis

Hinshelwood, Rebecca A., Huschtscha, Lily I., Melki, John, Stirzaker, Clare, Abdipranoto, Andrea, Vissel, Bryce, Ravasi, Timothy, Wells, Christine A., Hume, David A., Reddel, Roger R. and Clark, Susan J. (2007) Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67 24: 11517-11527. doi:10.1158/0008-5472.CAN-07-1284

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

Bode, K. A., Schroder, K., Hume, D. A., Ravasi, T., Heeg, K., Sweet, M. J. and Dalpke, A. H. (2007) Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology, 122 4: 596-606. doi:10.1111/j.1365-2567.2007.02678.x

Mammalian RNA polymerase II core promoters: insights from genome-wide studies

Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y and Hume, DA (2007) Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews Genetics, 8 6: 424-436. doi:10.1038/nrg2026

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1

Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., Cook, A. D., Himes, S. R., Hamilton, J. A. and Hume, D. A. (2007) Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. Journal of Leukocyte Biology, 82 1: 111-123. doi:10.1189/jlb.1206713

CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway

Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J., Hume, D. A., Stacey, K. J. and Sweet, M. J. (2006) CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. Journal of Immunology, 177 7: 4473-4480.

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006) A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 11: 1921-1923. doi:10.1096/fj.06-5848fje

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice

Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A. and Du, Hong (2006) Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice. American Journal of Pathology, 169 3: 916-926. doi:10.2353/ajpath.2006.051327

Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes"

Hume, David A. (2006) Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes". Journal of Immunology, 177 4: 2035-2035.

Transcriptional network dynamics in macrophage activation

Nilsson, Roland, Bajic, Vladimir B., Suzuki, Harukazu, di Bernardo, Diego, Bjorkegren, Johan, Katayama, Shintaro, Reid, James F., Sweet, Matthew J., Gariboldi, Manuela, Carninci, Piero, Hayashizaki, Yosihide, Hume, David A., Tegner, Jesper and Ravasi, Timothy (2006) Transcriptional network dynamics in macrophage activation. Genomics, 88 2: 133-142. doi:10.1016/j.ygeno.2006.03.022

Mice and men: Their promoter properties

Bajic, Vladimir B., Tan, Sin Lam, Christoffels, Alan, Schonbach, Christian, Lilpovich, Leonard, Yang, Liang, Hofmann, Oliver, Kruger, Adele, Hide, Winston, Kai, Chikatoshi, Kawai, Jun, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2006) Mice and men: Their promoter properties. Plos Genetics, 2 4: 614-626. doi:10.1371/journal.pgen.0020054

Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs

Maeda, Norihiro, Kasukawa,Takeya, Frith, Martin, Aturaliya, Rajith N., Forrest, Alistair R. R., Ravasi,Timothy, Teasdale, Rohan D., Wells, Christine A., Hume,David A. and Hayashizaki,Yoshihide (2006) Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs. PLoS Genetics, 2 4: 498-503. doi:10.1371/journal.pgen.0020062

Alternate transcription of the Toll-like receptor signaling cascade

Wells, C. A., Chalk, A. M., Forrest, A., Taylor, D., Waddell, N., Schroder, K., Himes, S. R., Faulkner, G., Lo, S., Kasukawa, T., Kawaji, H., Kai, C., Kawai, J., Katayama, S., Carninci, P., Hayashizaki, Y., Hume, D. A. and Grimmond, S. M. (2006) Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology, 7 2: R10.1-R10.17. doi:10.1186/gb-2006-7-2-r10

The JNK are important for development and survival of macrophages

Himes, S. Roy, Sester, David P., Ravasi, Timothy, Cronau, Stephen L., Sasmono, Tedjo and Hume, David A. (2006) The JNK are important for development and survival of macrophages. Journal Of Immunology, 176 4: 2219-2228.

An automatable screen for the rapid identification of proteins amenable to refolding

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006) An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 6: 1750-1757. doi:10.1002/pmic.200500056

Apoptotic cell removal in development and tissue homeostasis

Henson, P. M. and Hume, D. A. (2006) Apoptotic cell removal in development and tissue homeostasis. Trends In Immunology, 27 5: 244-250. doi:10.1016/j.it.2006.03.005

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

Brahmachary, M., Schonbach, C., Yang, L., Huang, E. L., Tan, S. L., Chowdhary, R., Krishnan, S. P. T., Lin, C. Y., Hume, D. A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y. and Bajic, V. B. (2006) Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. Bmc Bioinformatics, 7 Supp. 5: Article number S8. doi:10.1186/1471-2105-7-S5-S8

Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase

Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006) Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62 133-135. doi:10.1107/S17443091060000030

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome

Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., Fukuda, S., Ru, K., Frith, M., Gongora, M., Grimmond, S., Hume, D. A., Hayashizaki, Y. and Mattick, J. S. (2006) Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Research, 16 1: 11-19. doi:10.1101/gr.4200206

Focusing in on structural genomics: The University of Queensland structural biology pipeline

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006) Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 6: 281-289. doi:10.1016/j.bioeng.2006.09.002

Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks

Sharma, S. M., Hu, R., Bronisz, A., Meadows, N., Lusby, T., Fletcher, B., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2006) Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks. Critical Reviews In Eukaryotic Gene Expression, 16 3: 253-277.

Genome-wide analysis of mammalian promoter architecture and evolution

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Frith, Martin C., Forrest, Alistair R. R., Ravasi, Timothy, Grimmond, Sean M., Wells, Christine A., Hume, David A. and Hayashizaki, Yoshihide (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics, 38 6: 626-635. doi:10.1038/ng1789

Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

Inoue, Kenji, Kobayashi, Mika, Yano, Kiichiro, Miura, Mai, Izumi, Akashi, Mataki, Chikage, Doi, Takeshi, Hamakubo, Takao, Reid, Patrick C., Hume, David A., Yoshida, Minoru, Aird, William C., Kodama, Tatsuhiko and Minami, Takashi (2006) Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression. Arteriosclerosis Thrombosis And Vascular Biology, 26 12: 2652-2659. doi:10.1161/01.ATV.0000247247.89787.e7

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006) Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 1: 12-20. doi:10.1016/j.gene.2006.02.031

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006) Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 1: 68-73. doi:10.1016/j.pep.2006.05.006

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

Aung, H. T., Schroder, K., Himes, S. R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D. A., Sweet, M. J. and Ravasi, T. (2006) LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Faseb Journal, 20 9: 1315-1327. doi:10.1096/fj.05-5360com

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006) Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 1: 9-16. doi:10.1093/protein/gzi070

Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Wu, Andy C. K., Grondahl, Lisbeth, Jack, Kevin S., Foo, Michelle X., Trau, Matt, Hume, David A. and Cassady, Alan I. (2006) Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Biomaterials, 27 27: 4715-4725. doi:10.1016/j.biomaterials.2006.05.010

Signal integration between IFN gamma and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J. and Hume, D. A. (2006) Signal integration between IFN gamma and TLR signalling pathways in macrophages. Immunobiology, 211 6-8: 511-524. doi:10.1016/j.imbio.2006.05.007

The mononuclear phagocyte system

Hume, D. A. (2006) The mononuclear phagocyte system. Current Opinion In Immunology, 18 1: 49-53. doi:10.1016/j.coi.2005.11.008

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

Cochrane, Anita L., Kett, Michelle M., Samuel, Chrishan S., Campanale, Naomi V., Anderson, Warwick P., Hume, David A., Little, Melissa H., Bertram, John F. and Ricardo, Sharon D. (2005) Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. Journal of The American Society of Nephrology, 16 12: 3623-3630. doi:10.1681/ASN.2004090771

Therapeutic targets in inflammatory disease

Hume, David A. and Fairlie, David P. (2005) Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 25: 2925-2929. doi:10.2174/092986705774462923

The transcriptional landscape of the mammalian genome

The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005) The transcriptional landscape of the mammalian genome. Science, 309 5740: 1559-1563. doi:10.1126/science.1112014

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005) The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 3: 1399-1405.

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005) An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 2: 309-317. doi:10.1016/j.str.2004.12.013

Antisense transcription in the mammalian transcriptome

RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005) Antisense transcription in the mammalian transcriptome. Science, 309 5740: 1564-1566. doi:10.1126/science.1112009

Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides

Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005) Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 2: 605-608.

Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides

Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005) Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 6: 3569-3576.

Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.

Ripoll, V. M., Hume, D. A. and Fontanilla, M.R. (2005) Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.. Biomedica, 25 2: 261-270. doi:10.7705/biomedica.v25i2.1348

Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation

Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005) Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 2: 154-164. doi:10.1016/j.abb.2005.05.013

Inflammation suppressor genes: please switch out all the lights

Wells, C. A., Ravasi, T. and Hume, D. A. (2005) Inflammation suppressor genes: please switch out all the lights. Journal of Leukocyte Biology, 78 1: 9-13. doi:10.1189/jlb.1204710

LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action

Sester, D. P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J. A., McDonald, R. C., Ripoll, V., Wells, C. A., Suzuki, H., Hayashizaki, Y., Stacey, K. J., Hume, D. A. and Sweet, M. J. (2005) LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology, 210 2-4: 97-107. doi:10.1016/j.imbio.2005.05.004

Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing

Raisanen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A. and Vaananen, H. K. (2005) Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing. Biochemical And Biophysical Research Communications, 331 1: 120-126. doi:10.1016/j.bbrc.2005.03.133

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005) Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 2: 327-329. doi:10.1016/j.ab.2005.06.016

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005) Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 1: 13-20. doi:10.1007/s10969-005-0462-7

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., Reynolds, E. C., Hume, D. A., Hamilton, J. A., Geczy, C. L. and Anderson, G. P. (2005) S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 4 1: 136-145. doi:10.1021/pr049829t

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha

Murray, Rachael Z., Wylie, Fiona G., Khromykh, Tatiana, Hume, David A. and Stow, Jennifer L. (2005) Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha. Journal of Biological Chemistry, 280 11: 10478-10483. doi:10.1074/jbc.M414420200

The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages

Himes, S. R., Cronau, S., Mulford, C. and Hume, D. A. (2005) The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene, 24 34: 5278-5286. doi:10.1038/sj.onc.1208657

Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor

Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Sollner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., Hume, D. A. and Andreesen, R. (2005) Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of Immunology, 174 11: 7111-7122.

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible

Tagoh, Hiromi, Schebesta, Alexandra, Lefevre, Pascal, Wilson, Nicola, Hume, David, Busslinger, Meinrad and Bonifer, Constanze (2004) Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. The EMBO Journal, 23 21: 4275-4285. doi:10.1038/sj.emboj.7600421

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 2: 154-162. doi:10.1016/j.abb.2004.01.008

Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis

Kasukawa, T., Katayama, S., Kawaji, H., Suzuki, H., Hume, D. A. and Hayashizaki, Y. (2004) Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis. Genomics, 84 6: 913-921. doi:10.1016/j.ygeno.2004.08.011

Interferon-gamma: an overview of signals, mechanisms and functions

Schroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004) Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 2: 163-189. doi:10.1189/jlb.0603252

Probing the S100 protein family through genomic and functional analysis

Ravasi, Timothy, Hsu, Kenneth, Goyette, Jesse, Schroder, Kate, Yang, Zheng, Rahimi, Farid, Miranda, Les P., Alewood, Paul F., Hume, David A. and Geczy, Carolyn (2004) Probing the S100 protein family through genomic and functional analysis. Genomics, 84 1: 10-22. doi:10.1016/j.ygeno.2004.02.002

Rasputin, more promiscuous than ever: a review of G3BP

Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004) Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 10: 1065-1077. doi:10.1387/ijdb.041893ki

Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection

McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D. and Wainwright, B. (2003) Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infection And Immunity, 71 10: 6035-6044. doi:10.1128/IAI.71.10.6035-6044.2003

Regulation of the murine TRACP gene promoter

Cassady, A. I., Luchin, A., Ostrowski, M. C. and Hume, David A. (2003) Regulation of the murine TRACP gene promoter. Journal of Bone And Mineral Research, 18 10: 1901-1904. doi:10.1359/jbmr.2003.18.10.1901

Genetic control of the innate immune response

Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B. J. and Hume, D. A. (2003) Genetic control of the innate immune response. BMC Immunology, 4 Article 5: 1-18. doi:10.1186/1471-2172-4-5

Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome

Zavolan, M., Kondo, S., Schonbach, C., Adachi, J., Hume, D. A., Hayashizaki, Y., Gaasterland, T., RIKEN GER Grp and GLS Members (2003) Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Research, 13 6B: 1290-1300. doi:10.1101/gr.1017303

Phosphoregulators: Protein kinases and protein phosphatases of mouse

Forrest, Alistair R. R., Ravasi, Timothy, Taylor, Darrin, Huber, Thomas L., Hume, David A., RIKEN GER Group, GSL Members and Grimmond, Sean (2003) Phosphoregulators: Protein kinases and protein phosphatases of mouse. Genome Research, 13 6B: 1443-1454. doi:10.1101/gr.954803

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA

Stacey, Katryn J., Young, Greg R., Clark, Francis, Sester, David P., Roberts, Tara L., Naik, Shalin, Sweet, Matthew J. and Hume, David A. (2003) The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. Journal of Immunology, 170 7: 3614-3620.

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse

Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R. and Hume, D. A. (2003) A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 101 3: 1155-1163. doi:10.1182/blood-2002-02-1569

CSF-1 as a regulator of macrophage activation and immune responses

Sweet, MJ and Hume, DA (2003) CSF-1 as a regulator of macrophage activation and immune responses. Archivum Immunologiae Et Therapiae Experimentalis, 51 3: 169-177.

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage

Wells, C. A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Faulkner, G. J., Okazaki, Y., Quackenbush, J., Hume, D. A., RIKEN GER Group,, GSL Members, and Lyons, P. A. (2003) Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Research, 13 6B: 1360-1365. doi:10.1101/gr.1056103

Development and evaluation of an automated annotation pipeline and cDNA annotation system

Kasukawa, T., Furuno, M., Nikaido, I., Bono, H., Hume, D. A., Bult, C., Hill, D. P., Baldarelli, R., Gough, J., Kanapin, A., Matsuda, H., Schriml, L. M., Hayashizaki, Y., Okazaki, Y. and Quackenbush, J. (2003) Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Research, 13 6B: 1542-1551. doi:10.1101/gr.992803

Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome

Tajul Arifin, K., Teasdale, R. D., Ravasi, T., Hume, D. A., RIKEN GER Group,, GSL Members, and Mattick, J. S. (2003) Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Reaserch, 13 6B: 1416-1429. doi:10.1101/gr.1015703

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection

Numata, K., Kanai, A., Saito, R., Kondo, S., Adachi, J., Wilming, L. G., Hume, D. A., RIKEN GER Group,, GSL Members,, Hayashizaki, Y. and Tomita, M. (2003) Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Research, 13 6B: 1301-1306. doi:10.1101/gr.1011603

Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene

Walsh, N. C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D. A. and Cassady, A. I. (2003) Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene, 307 111-123. doi:10.1016/S0378-1119(03)00449-9

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome

Ravasi, T., Huber, T. L., Zavolan, M., Forrest, A. R., Gaasterland, T., Grimmond, S. M., RIKEN GER Group,, GSL Members, and Hume, D. A. (2003) Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome. Genome Research, 13 6B: 1430-1442. doi:10.1101/gr.949803

The mouse secretome: functional classification of the proteins secreted into the extracellular environment

Grimmond, Sean M., Miranda, Kevin C., Yuan, Zheng, Davis, Melissa J., Hume, David A., Yagi, Ken, Tominaga, Naoko, Bono, Hidemasa, Hayashizaki, Yoshihide, Okazaki, Yasushi, RIKEN GER Group,, GSL Members, and Teasdale, Rohan D. (2003) The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Research, 13 6B: 1350-1359. doi:10.1101/gr.983703

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Teasdale, R. D., Hume, D. A., Yuan, Zheng and The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team (2002) Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420 6915: 563-573. doi:10.1038/nature01266

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities

Oceandy, Delvac, McMorran, Brendan J., Smith, Stephen N., Schreiber, Rainer, Kunzelmann, Karl, Alton, Eric W. F. W., Hume, David A. and Wainwright, Brandon J. (2002) Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics, 11 9: 1059-1067. doi:10.1093/hmg/11.9.1059

NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells

Xie, Y., Chen, C. M., Stevenson, M. A., Hume, D. A., Auron, P. E. and Calderwood, S. K. (2002) NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochemical And Biophysical Research Communications, 291 4: 1071-1080. doi:10.1006/bbrc.2002.6562

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages

Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., Hume, David A. and Liew, Foo Y. (2002) Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. Journal of Immunology, 168 1: 392-399.

Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S. and Hume, D. A. (2002) Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes. Journal of Immunology, 168 1: 44-50.

Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism

Wardrop, S. L., Wells, C., Ravasi, T., Hume, D. A. and Richardson, D. R. (2002) Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism. Journal of Leukocyte Biology, 71 1: 99-106.

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. and Ostrowski, M. C. (2002) The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts. Journal of Leukocyte Biology, 71 2: 295-303.

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter

Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. and Ostrowski, M. C. (2002) The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. Journal of Leukocyte Biology, 71 2: 304-310.

The mononuclear phagocyte system revisited

Hume, David A., Ross, Ian L., Himes, S. Roy, Sasmono, R. Tedjo, Wells, Christine A. and Ravasi, Timothy (2002) The mononuclear phagocyte system revisited. Journal of Leukocyte Biology, 72 4: 621-627.

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells

Tagoh, H., Himes, R., Clarke, D., Leenen, P. J. M., Riggs, A. D., Hume, D. and Bonifer, C. (2002) Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes and Development, 16 13: 1721-1737. doi:10.1101/gad.222002

A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression

Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, T., Oceandy, D., Clark, R., Bonifer, C. and Hume, D. A. (2001) A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. Journal of Leukocyte Biology, 70 5: 812-820.

G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease

Mcmorran, B., Palmer, J., Lunn, D., Oceandy, D., Costelloe, E. O., Thomas, G., Hume, D. A. and Wainwright, B. J. (2001) G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. AJP-Lung Cellular and Molecular Physiology, 281 3: 740-747.

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation

Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2001) Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. Journal of Biological Chemistry, 276 39: 36703-36710. doi:10.1074/jbc.M106418200

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state

Hume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A.O., Liew, F.Y. and Aderem, A. (2001) Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunology, 2 11: 1-12. doi:10.1186/1471-2172-2-11

Structural genomics: Protein structures for the masses?

Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001) Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 2: 13-16.

Transcriptional regulation of c-fms gene expression

Xie, Y., Chen, C. M. and Hume, D. A. (2001) Transcriptional regulation of c-fms gene expression. Cell Biochemistry And Biophysics, 34 1: 1-16. doi:10.1385/CBB:34:1:001

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000) Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 5: 575-584. doi:10.1016/S8756-3282(00)00368-9

G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages

Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000) G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 7: 3870-3877.

Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction

Dwidedi, P. P., Omdahl, J. L., Kola, I., Hume, D. A. and Kay, B. K. (2000) Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction. Journal of Biological Chemistry, 275 1: 47-55. doi:10.1074/jbc.275.1.47

Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene

Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A. and Sester, D. (2000) Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. The FASEB Journal, 15 15: 2393-2395.

How do you see CG

Aderem, A. and Hume, D. A. (2000) How do you see CG. Cell, 103 7: 993-996. doi:10.1016/S0092-8674(00)00201-4

Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.

Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000) Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 4: 427-438. doi:10.1089/107999000312379

Macrophage activation by immunostimulatory DNA

Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000) Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247 41-58.

Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1

Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000) Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 8: 4165-4173.

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000) Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 2: 419-424. doi:10.1016/S0378-1119(00)00305-X

Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor

Fowles, L. F., Stacey, K. J., Marks, D., Hamilton, J. A. and Hume, D. A. (2000) Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochemical Journal, 347 1: 313-320. doi:10.1042/0264-6021:3470313

The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts

Luchin, A., Purdom, G., Murphy, K. M., Clark, M., Angel, N., Cassady, A. I., Hume, D. A. and Ostrowski, M. (2000) The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts. Journal of Bone and Mineral Research, 15 3: 451-460. doi:10.1359/jbmr.2000.15.3.451

Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover

Angel, N., Cahill, M. M., King, A., Ostrowski, M., Cassady, A. I. and Hume, D. A. (2000) Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover. Journal of Bone and Mineral Research, 15 1: 103-110. doi:10.1359/jbmr.2000.15.1.103

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo

Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999) A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 4: 2209-2216.

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999) Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 4: 279-291. doi:10.3109/08977199909069146

Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999) Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 12: 6541-6550.

CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages

Kakuda, D. K., Sweet, M. J., MacLeod, C. L., Hume, D. A. and Markovich, D. (1999) CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochemical Journal, 340 2: 549-553. doi:10.1042/0264-6021:3400549

Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide

Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999) Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 3: 528-534.

Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin

Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999) Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 1: 172-183.

The actions of bacterial DNA on murine macrophages

Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999) The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 4: 542-548.

Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling

Fowles, Lindsay F., Martin, Michele L., Nelsen, Lori, Stacey, Katryn J., Redd, Douglas, Clark, Ying Mei, Nagamine, Yoshikune, McMahon, Martin, Hume, David A. and Ostrowski, Michael C. (1998) Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling. Molecular and Cellular Biology, 18 9: 5148-5156. doi:10.1128/MCB.18.9.5148

Regulation of CSF-1 receptor expression

Hume, D. A., Yue, X., Ross, I. L., Favot, P., Lichanska, A. and Ostrowski, M. C. (1997) Regulation of CSF-1 receptor expression. Molecular Reproduction and Development, 46 1: 46-53. doi:10.1002/(SICI)1098-2795(199701)46:1<46::AID-MRD8>3.0.CO;2-R

Endotoxin signal transduction in macrophages

Sweet, M. J. and Hume, D. A. (1996) Endotoxin signal transduction in macrophages. Journal of Leukocyte Biology, 60 1: 8-26.

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

Yang, Beom-Seok, Hauser, Craig A., Henkel, Gregory, Colman, Michael S., Van Beveren, Charles, Stacey, Katryn J., Hume, David A., Maki, Richard A. and Ostrowski, Michael C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Molecular and Cellular Biology, 16 2: 538-547. doi:10.1128/MCB.16.2.538

Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor

Stacey, Katryn J., Fowles, Lindsay F., Colman, Michael S., Ostrowski, Michael C. and Hume, David A. (1995) Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Molecular and Cellular Biology, 15 6: 3430-3441. doi:10.1128/MCB.15.6.3430

RNA synthesis inhibition stabilises urokinase mRNA in macrophages

Stacey, Katryn J., Nagamine, Yoshikuni and Hume, David A. (1994) RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letters, 356 2-3: 311-313. doi:10.1016/0014-5793(94)01294-6

The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin

Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993) The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 3: 392-401. doi:10.1111/j.1365-2141.1993.tb03092.x

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991) Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 24: 6839-6847. doi:10.1093/nar/19.24.6839

Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing

Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. In: Journal of Bone and Mineral Research. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, (). 11-15 September, 2009.

Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation

Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. In: Abstracts of the 35th European Symposium on Calcified Tissues. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, (S98-S99). 24-28 May 2008. doi:10.1007/s00223-008-9118-5

Osteal Macrophages: Novel regulators of Bone Formation

Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. In: Journal of Bone and Mineral Research: 29th Annual Meeting of the American Society for Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, (s53-s53). 16th -19th September, 2007.

The endosteal bone niche contains macrophages that regulate osteoblast function

Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. In: Bone. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, (S127-S127). 24-29 June 2007. doi:10.1016/j.bone.2007.04.166

Structure and function of mammalian fibrillin genes

Summers, K and Hume, D A (2006). Structure and function of mammalian fibrillin genes. In: 11th International Congress of Human Genetics. 11th International Congress of Human Genetics, Brisbane, (Abstract). 6-10 Aug, 2006.

The use of transgenes to study macrophage differentiation and function

Hume, D. A. (2006). The use of transgenes to study macrophage differentiation and function. In: Bruce Whitelaw and Paul Christou, Program and Abstracts of the 7th Transgenic Technology Meeting (TT2007). 7th Transgenic Technology Meeting (TT2007), St Lucia, Brisbane, Australia, (778-779). 12-14 February 2007. doi:10.1007/s11248-006-9047-x

Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS

Hume, David A., Ravasi, Timothy and Wells, Christine (2004). Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS. In: 1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), Budapest, Hungary, (330-330). 3-7 October 2004. doi:10.1111/j.1399-0039.2004.00315.x

Clues to interaction between CSF-1 and CSF-1R from specificity and structure

Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. In: Australian Society of Immunologists Meeting. Australian Society of Immunologists Meeting, Brisbane, ((Poster)). 1-5 December, 2002.

Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer

Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. In: International Conference on Structural Genomics. International Conference on Structural Genomics, Berlin, ((Abstract)). 10-13 October, 2002.

Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. In: ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, (). 29 September -3 October, 2002.

Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. In: Australian Society for Immunology Meeting. Australian Society for Immunology Meeting, Brisbane, ((Abstract)). 1-5 December, 2002.

Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides

Pickering, D., Hume, D. A. and Young, P. R. (2001). Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides. In: 6th International Symposium on Positive Strand Viruses, Paris, France, ((Abstract)). 28 May - 2 June, 2001.

An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages

Himes, S. R., Goonetilleke, N. P. and Hume, D. A. (1999). An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-11-04). 27-30 September, 1999.

CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. In: Innate Resistant to Infection, Society for Leukocyte Biology. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, (). 22-26 September, 1999.

Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-05-01). 27-30 September, 1999.

Crystallisation of a mammalian purple acid phosphatase

Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. In: 24th Annual Lorne Conference on Protein Structure and Function. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., (C10). 7-11 February, 1999.

ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice

Ostrowski, M., Erbe, L. S., Hume, D. A. and Smith, J. L. (1999). ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice. In: Combined Conference Abstratcs: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-55-01). 27-30 September, 1999.

Immunostimulatory DNA promotes factor independent survival of macrophages

Sester, D. P., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). Immunostimulatory DNA promotes factor independent survival of macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-45-04). 27-30 September, 1999.

Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse

Walsh, N., Angel, N., Williams, E. A., Cassady, A. I. and Hume, D. A. (1999). Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-04-05). 27-30 September, 1999.

Post-Golgi trafficking of TNF-a in macrophages

Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-13-05). 27-30 September 1999.

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Cassady, A. I., Suchting, S. J., Angel, N., Merson, T. D. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. In: Journal of Bone and Mineral Research. 21st Annual Meeting of the ASBMR, St Louis, USA, (S244). 30 Sept - 4 Oct, 1999.

The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1

Suchting, S. J., Merson, T. D., Angel, N., Cassady, A. I. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Mon-74). 27th - 30th September, 1999.

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

Cassady, A. I., Walsh, N., Angel, N., Cahill, M. M., Forwood, M. R., Ostrowski, M. and Hume, D. A. (1999). Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. In: Australian and New Zealand Bone and Mineral Society Conference. 9th Annual Scientific Meeting ANZBMS, Cairns, (). 30 June - 2 July, 1999.