The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.
David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute
Book Chapter: Genetic and immunohistochemistry tools to visualize rat macrophages in situ
Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6
Journal Article: Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development
Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052
Conference Publication: Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease
Whiley, P., Summers, K., Pavli, P., Hume, D. and O'Brien, C. (2023). Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease. HOBOKEN: WILEY.
Macrophage Biology in Health and Disease
(2022–2026) NHMRC Investigator Grants
Macrophage control of mammalian growth and development
(2021–2024) ARC Discovery Projects
CSF1 Therapy for Chronic Liver Disease
(2019–2022) NHMRC Project Grant
Macrophage colony stimulating factor in the treatment of non-alcoholic fatty liver disease
Doctor Philosophy
(2023) Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
(2023) Doctor Philosophy
The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701
The network collective: Rise and fall of a scientific paradigm
Eichmann, Klaus, Avery, Oswald T., Baltimore, David, Von Behring, Emil, Benacerraf, Baruj, Bloor, David, Bordet, Jules J.B.V., Bona, Constantin A., Boyse, Edward A., Burnet, F. Macfarlane, Cantor, Harvey, Cazenave, Pierre A., Claman, Henry N., Cohn, Melvin, Coutinho, Antonio, Davis, Mark M., Crick, Francis H., Dobzhansky, Theodosius G., Doherty, Peter C., Eco, Umberto, Edelman, Gerald M., Ehrlich, Paul, Feyerabend, Paul, Fleck, Ludwik, Fujimura, Joan, Gershon, Richard K., Germain, Ronald N., Gowans, James L., Greene, Mark I. ... Zinkernagel, Rolf M. (2008). The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG. doi: 10.1007/978-3-7643-8373-2
Genetic and immunohistochemistry tools to visualize rat macrophages in situ
Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6
Transcriptional regulation and macrophage differentiation
Hume, David A., Summers, Kim M. and Rehli, Michael (2017). Transcriptional regulation and macrophage differentiation. Myeloid cells in health and disease: a synthesis. (pp. 119-139) edited by Siamon Gordon. Washington, DC United States: ASM Press. doi: 10.1128/9781555819194.ch8
The impact of CAGE data on understanding macrophage transcriptional biology
Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription. (pp. 227-243) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814241359
The impact of CAGE data on the understanding of macrophage transcriptional biology
Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription. (pp. 227-244) edited by Piero Carninci. Singapore: Pan Stanford Publishing.
A general target selection method for crystallographic proteomics
Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2
A medium or high throughput protein refolding assay
Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17
Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38
Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31
Transcriptional Regulatory Networks in Macrophages
Hume, David A., Wells, Christine A. and Ravasi, Timothy (2007). Transcriptional Regulatory Networks in Macrophages. Decoding the Genomic Control of Immune Reactions. (pp. 2-24) Chichester, UK: wiley. doi: 10.1002/9780470062128.ch2
Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics. (pp. xx-xx) edited by Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam. USA: John Wiley & Sons, Inc.. doi: 10.1002/047001153X.g203204
Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. The Innate Immune Response to Infection. (pp. 71-94) edited by Kaufmann, SE.; Medzhitov, R.; Gordon and S.. Washington, DC, USA: ASM Press.
Phosphorothioate backbone modification changes the pattern of responses to CpG
Stacey, K. J., Sester, D. P., Naik, S., Roberts, T., Sweet, M. J. and Hume, D. A. (2002). Phosphorothioate backbone modification changes the pattern of responses to CpG. Microbial DNA and host immunity. (pp. 63-77) Totowa, New Jersey: Humana Press. doi: 10.1007/978-1-59259-305-7_6
Growth and differentiation of murine macrophages
Hume, D. A., Stacey, K. J., Cassady, A. ., Browne, C. M., Sweet, M. J. and Bertoncello, I. (1996). Growth and differentiation of murine macrophages. Handbook of experimental immunology. (pp. 160.1-160.10) Boston: Wiley-Blackwell.
The regulation of urokinase plasminogen activator gene expression in macrophages
Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. Mononuclear Phagocytes: Biology of Monocytes and Macrophages. (pp. 233-240) edited by van Furth, R.. Dordrecht , Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8070-0
Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052
Macrophage heterogeneity in the single cell era: facts and artefacts
Hume, David A, Millard, Susan M and Pettit, Allison R. (2023). Macrophage heterogeneity in the single cell era: facts and artefacts. Blood Journal, 142 (16), 1339-1347. doi: 10.1182/blood.2023020597
Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312. doi: 10.1002/eji.202250312
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression
Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028
Hume, David A. (2023). Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?. European Journal of Immunology, 53 (6) 2250242. doi: 10.1002/eji.202250242
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Grootveld, Abigail K., Kyaw, Wunna, Panova, Veera, Lau, Angelica W.Y., Ashwin, Emily, Seuzaret, Guillaume, Dhenni, Rama, Bhattacharyya, Nayan Deger, Khoo, Weng Hua, Biro, Maté, Mitra, Tanmay, Meyer-Hermann, Michael, Bertolino, Patrick, Tanaka, Masato, Hume, David A., Croucher, Peter I., Brink, Robert, Nguyen, Akira, Bannard, Oliver and Phan, Tri Giang (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell, 186 (6), 1144-1161. doi: 10.1016/j.cell.2023.02.004
Fibrillin-1 and asprosin, novel players in metabolic syndrome
Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979
Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784
Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y
Microglia states and nomenclature: A field at its crossroads
Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam ... Wyss-Coray, Tony (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi: 10.1016/j.neuron.2022.10.020
CSF1R as a therapeutic target in bone diseases: obvious but not so simple
Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4
Poincaré profiles of Lie groups and a coarse geometric dichotomy
Hume, David, Mackay, John M. and Tessera, Romain (2022). Poincaré profiles of Lie groups and a coarse geometric dichotomy. Geometric and Functional Analysis, 32 (5), 1063-1133. doi: 10.1007/s00039-022-00617-4
Graphia: a platform for the graph-based visualisation and analysis of high dimensional data
Freeman, Tom C., Horsewell, Sebastian, Patir, Anirudh, Harling-Lee, Josh, Regan, Tim, Shih, Barbara B., Prendergast, James, Hume, David A. and Angus, Tim (2022). Graphia: a platform for the graph-based visualisation and analysis of high dimensional data. PLOS Computational Biology, 18 (7) e1010310, 1-17. doi: 10.1371/journal.pcbi.1010310
Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
Hume, David A., Offermanns, Stefan and Bonnavion, Remy (2022). Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55 (7), 1139-1140. doi: 10.1016/j.immuni.2022.06.010
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek and Blurton-Jones, Mathew (2022). Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Reports, 39 (11) 110961, 1-30. doi: 10.1016/j.celrep.2022.110961
Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer
Laviron, Marie, Petit, Maxime, Weber-Delacroix, Eléonore, Combes, Alexis J., Arkal, Arjun Rao, Barthélémy, Sandrine, Courau, Tristan, Hume, David A., Combadière, Christophe, Krummel, Matthew F. and Boissonnas, Alexandre (2022). Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. Cell Reports, 39 (8) 110865, 1-20. doi: 10.1016/j.celrep.2022.110865
Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237
Generation and network analysis of an RNA-seq transcriptional atlas for the rat
Summers, Kim M., Bush, Stephen J., Wu, Chunlei and Hume, David A. (2022). Generation and network analysis of an RNA-seq transcriptional atlas for the rat. NAR Genomics and Bioinformatics, 4 (1) lqac017, lqac017. doi: 10.1093/nargab/lqac017
Pettit, Allison R, Batoon, Lena, Heng, Ostyn, Hume, David, Irvine, Kate, Kaur, Simranpreet, Levesque, Jean-Pierre, Magor, Graham, Millard, Susan, Noll, Jacqueline, Perkins, Andrew, Raggatt, Liza, Sandrock, Cheyenne, Sehgal, Anuj, Sester, David, Opperman, Khatora Shanae, Summers, Kim, Wu, Andy and Zannettino, Andrew (2022). 1015 – APPEARANCES CAN BE DECEIVING: MACROPHAGE FRAGMENTATION CONFOUNDS EX VIVO HAEMATOPOIETIC TISSUE ANALYSIS. Experimental Hematology, 111, S23. doi: 10.1016/j.exphem.2022.07.018
Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells
Hume, David A. (2022). Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells. Hepatology, 78 (2), n/a-n/a. doi: 10.1002/hep.32809
Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain
Bradford, Barry M., McGuire, Lynne I., Hume, David A., Pridans, Clare and Mabbott, Neil A. (2022). Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain. GLIA, 70 (11), 2169-2187. doi: 10.1002/glia.24244
Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387
Lisowski, Zofia M., Lefevre, Lucas, Mair, Tim S., Clark, Emily L., Hudson, Neil P. H., Hume, David A. and Pirie, R. Scott (2022). Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection. Equine Veterinary Journal, 54 (1), 52-62. doi: 10.1111/evj.13429
Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z
Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature Communications, 12 (1) 3297. doi: 10.1038/s41467-021-23143-7
Psifidi, Androniki, Kranis, Andreas, Rothwell, Lisa M., Bremner, Abi, Russell, Kay, Robledo, Diego, Bush, Stephen J., Fife, Mark, Hocking, Paul M., Banos, Georgios, Hume, David A., Kaufman, Jim, Bailey, Richard A., Avendano, Santiago, Watson, Kellie A., Kaiser, Pete and Stevens, Mark. P. (2021). Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter. Scientific Reports, 11 (1) 1623. doi: 10.1038/s41598-020-79005-7
Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058
Wu, Zhiguang, Hu, Tuanjun, Chintoan-Uta, Cosmin, Macdonald, Joni, Stevens, Mark P., Sang, Helen, Hume, David A., Kaiser, Pete and Balic, Adam (2021). Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells. Immunology, 165 (2), 171-194. doi: 10.1111/imm.13426
Sehgal, Anuj, Irvine, Katharine M. and Hume, David A. (2021). Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Seminars in Immunology, 54 101509, 101509. doi: 10.1016/j.smim.2021.101509
Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation
Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605
Actions of small cancellation groups on hyperbolic spaces
Abbott, Carolyn R. and Hume, David (2021). Actions of small cancellation groups on hyperbolic spaces. Geometriae Dedicata, 212 (1), 325-363. doi: 10.1007/s10711-020-00561-3
Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Rojo, Rocio, Hume, David A., Lengeling, Andreas and Summers, Kim M. (2021). CRISPR-Cas9 editing of human histone deubiquitinase gene USP16 in human monocytic leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 9 679544. doi: 10.3389/fcell.2021.679544
The mononuclear phagocyte system of the rat
Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136
Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268
Karagianni, Anna E., Lisowski, Zofia M., Hume, David A. and Scott Pirie, R. (2021). The equine mononuclear phagocyte system: the relevance of the horse as a model for understanding human innate immunity. Equine Veterinary Journal, 53 (2), 231-249. doi: 10.1111/evj.13341
Whole-genome sequence data suggest environmental adaptation of Ethiopian sheep populations
Wiener, Pamela, Robert, Christelle, Ahbara, Abulgasim, Salavati, Mazdak, Abebe, Ayele, Kebede, Adebabay, Wragg, David, Friedrich, Juliane, Vasoya, Deepali, Hume, David A., Djikeng, Appolinaire, Watson, Mick, Prendergast, James G D, Hanotte, Olivier, Mwacharo, Joram M. and Clark, Emily L. (2021). Whole-genome sequence data suggest environmental adaptation of Ethiopian sheep populations. Genome Biology and Evolution, 13 (3) evab014, 1-18. doi: 10.1093/gbe/evab014
Transcriptomic analysis of rat macrophages
Pridans, Clare, Irvine, Katharine M, Davis, Gemma M, Lefevre, Lucas, Bush, Stephen J and Hume, David A (2021). Transcriptomic analysis of rat macrophages. Frontiers in Immunology, 11 594594. doi: 10.3389/fimmu.2020.594594
On the utility of CSF1R inhibitors
Green, Kim N. and Hume, David A. (2021). On the utility of CSF1R inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 118 (4) e2019695118, 1-2. doi: 10.1073/pnas.2019695118
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w
CNS macrophages differentially rely on an intronic Csf1r enhancer for their development
Munro, David A.D., Bradford, Barry M., Mariani, Samanta A., Hampton, David W., Vink, Chris S., Chandran, Siddharthan, Hume, David A., Pridans, Clare and Priller, Josef (2020). CNS macrophages differentially rely on an intronic Csf1r enhancer for their development. Development, 147 (23) dev194449, 1-9. doi: 10.1242/dev.194449
Grabert, Kathleen, Sehgal, Anuj, Irvine, Katharine M., Wollscheid-Lengeling, Evi, Ozdemir, Derya D., Stables, Jennifer, Luke, Garry A., Ryan, Martin D., Adamson, Antony, Humphreys, Neil E., Sandrock, Cheyenne J., Rojo, Rocio, Verkasalo, Veera A., Mueller, Werner, Hohenstein, Peter, Pettit, Allison R., Pridans, Clare and Hume, David A. (2020). A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system. Journal of Immunology, 205 (11), 3154-3166. doi: 10.4049/jimmunol.2000835
Dutta, Prasun, Talenti, Andrea, Young, Rachel, Jayaraman, Siddharth, Callaby, Rebecca, Jadhav, Santosh Kumar, Dhanikachalam, Velu, Manikandan, Mayakannan, Biswa, Bhim B., Low, Wai Y., Williams, John L., Cook, Elizabeth, Toye, Phil, Wall, Eileen, Djikeng, Appolinaire, Marshall, Karen, Archibald, Alan L., Gokhale, Suresh, Kumar, Satish, Hume, David A. and Prendergast, James G. D. (2020). Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication. Nature Communications, 11 (1) 4739. doi: 10.1038/s41467-020-18550-1
Hume, David and Mackay, John M. (2020). Poorly connected groups. Proceedings of the American Mathematical Society, 148 (11), 4653-4664. doi: 10.1090/proc/15128
Summers, Kim M., Bush, Stephen J. and Hume, David A. (2020). Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system. PLoS Biology, 18 (10) e3000859, 1-45. doi: 10.1371/journal.pbio.3000859
Gow, Deborah J., Jackson, Hilary, Forsythe, Peter, Nuttall, Tim, Gow, Adam G., Mellanby, Richard J. and Hume, David A. (2020). Measurement of serum Interleukin 34 (IL-34) and correlation with severity and pruritus scores in client-owned dogs with atopic dermatitis. Veterinary Dermatology, 31 (5), 359-e94. doi: 10.1111/vde.12873
Tsang, Hiu-Gwen, Clark, Emily L., Markby, Greg R., Bush, Stephen J., Hume, David A., Corcoran, Brendan M., MacRae, Vicky E. and Summers, Kim M. (2020). Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries). Frontiers in Genetics, 11 919. doi: 10.3389/fgene.2020.00919
Lisowski, Zofia M., Sauter, Kristin A., Waddell, Lindsey A., Hume, David A., Pirie, R. Scott and Hudson, Neil P.H. (2020). Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract. Veterinary Immunology and Immunopathology, 226 110073, 110073. doi: 10.1016/j.vetimm.2020.110073
Bush, Stephen J., McCulloch, Mary E. B., Lisowski, Zofia M., Muriuki, Charity, Clark, Emily L., Young, Rachel, Pridans, Clare, Prendergast, James G. D., Summers, Kim M. and Hume, David A. (2020). Species-specificity of transcriptional regulation and the response to lipopolysaccharide in mammalian macrophages. Frontiers in Cell and Developmental Biology, 8 661. doi: 10.3389/fcell.2020.00661
Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Clohisey, Sara, Arner, Erik, de Hoon, Michiel, Severin, Jessica, van Duin, Lucas, Andersson, Robin, Lengeling, Andreas, Hume, David A. and Summers, Kim M. (2020). The transcriptional network that controls growth arrest and macrophage differentiation in the human myeloid leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 8 498. doi: 10.3389/fcell.2020.00498
An improved pig reference genome sequence to enable pig genetics and genomics research
Warr, Amanda, Affara, Nabeel, Aken, Bronwen, Beiki, Hamid, Bickhart, Derek M., Billis, Konstantinos, Chow, William, Eory, Lel, Finlayson, Heather A., Flicek, Paul, Girón, Carlos G., Griffin, Darren K., Hall, Richard, Hannum, Greg, Hourlier, Thibaut, Howe, Kerstin, Hume, David A., Izuogu, Osagie, Kim, Kristi, Koren, Sergey, Liu, Haibou, Manchanda, Nancy, Martin, Fergal J., Nonneman, Dan J., O'Connor, Rebecca E., Phillippy, Adam M., Rohrer, Gary A., Rosen, Benjamin D., Rund, Laurie A. ... Archibald, Alan L. (2020). An improved pig reference genome sequence to enable pig genetics and genomics research. GigaScience, 9 (6) GIAA051. doi: 10.1093/gigascience/giaa051
Wittenberg, Gayle M., Stylianou, Annie, Zhang, Yun, Sun, Yu, Gupta, Ashutosh, Jagannatha, P. S., Wang, Dai, Hsu, Benjamin, Curran, Mark E., Khan, Shahid, Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Carvalho, Livia, Bell, Joshua, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil ... MRC ImmunoPsychiatry Consortium (2020). Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders. Molecular Psychiatry, 25 (6), 1275-1285. doi: 10.1038/s41380-019-0471-8
Clohisey, Sara, Parkinson, Nicholas, Wang, Bo, Bertin, Nicolas, Wise, Helen, Tomoiu, Andru, Summers, Kim M., Hendry, Ross W., Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Digard, Paul, Hume, David A. and Baillie, J. Kenneth (2020). Comprehensive characterization of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences. Journal of Virology, 94 (10) e01720-19. doi: 10.1128/JVI.01720-19
Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system
Wu, Zhiguang, Harne, Rakhi, Chintoan-Uta, Cosmin, Hu, Tuan-Jun, Wallace, Robert, MacCallum, Amanda, Stevens, Mark P., Kaiser, Pete, Balic, Adam and Hume, David A. (2020). Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system. Developmental and Comparative Immunology, 105 103586, 103586. doi: 10.1016/j.dci.2019.103586
Poincaré profiles of groups and spaces
Hume, David, Mackay, John M. and Tessera, Romain (2020). Poincaré profiles of groups and spaces. Revista Matematica Iberoamericana, 36 (6), 1835-1886. doi: 10.4171/RMI/1184
Summers, Kim M., Bush, Stephen J., Wu, Chunlei, Su, Andrew I., Muriuki, Charity, Clark, Emily L., Finlayson, Heather A., Eory, Lel, Waddell, Lindsey A., Talbot, Richard, Archibald, Alan L. and Hume, David A. (2020). Functional annotation of the transcriptome of the pig, Sus scrofa, based upon network analysis of an RNAseq transcriptional atlas. Frontiers in Genetics, 10 1355. doi: 10.3389/fgene.2019.01355
Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C. A., Beveridge, A. J., Brown, H., Hume, D. A., Harris, S. E., Deary, I. J., Tenesa, A. and Prendergast, J. G.D. (2020). Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. Nature Communications, 11 (1) 343. doi: 10.1038/s41467-019-13762-6
The geometry of generalized loxodromic elements
Abbott, Carolyn R. and Hume, David (2020). The geometry of generalized loxodromic elements. Annales de l'Institut Fourier, 70 (4), 1689-1713. doi: 10.5802/AIF.3379
Banos, Georgios, Clark, Emily L., Bush, Stephen J., Dutta, Prasun, Georgios Bramis, D., Arsenos, Georgios, Hume, David A. and Psifidi, Androniki (2019). Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep. PLoS One, 14 (11) e0214346, e0214346. doi: 10.1371/journal.pone.0214346
Halachev, Mihail, Meynert, Alison, Taylor, Martin S., Vitart, Veronique, Kerr, Shona M., Klaric, Lucija, Consortium, S. G.P., Aitman, Timothy J., Haley, Chris S., Prendergast, James G., Pugh, Carys, Hume, David A., Harris, Sarah E., Liewald, David C., Deary, Ian J., Semple, Colin A. and Wilson, James F. (2019). Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. PLoS Genetics, 15 (11) e1008480, e1008480. doi: 10.1371/journal.pgen.1008480
Freem, Lucy, Summers, Kim M., Gheyas, Almas A., Psifidi, Androniki, Boulton, Kay, MacCallum, Amanda, Harne, Rakhi, O’Dell, Jenny, Bush, Stephen J. and Hume, David A. (2019). Analysis of the progeny of sibling matings reveals regulatory variation impacting the transcriptome of immune cells in commercial chickens. Frontiers in Genetics, 10 1032. doi: 10.3389/fgene.2019.01032
A mini-atlas of gene expression for the domestic goat (Capra hircus)
Muriuki, Charity, Bush, Stephen J., Salavati, Mazdak, McCulloch, Mary E.B., Lisowski, Zofia M., Agaba, Morris, Djikeng, Appolinaire, Hume, David A. and Clark, Emily L. (2019). A mini-atlas of gene expression for the domestic goat (Capra hircus). Frontiers in Genetics, 10 1080, 1080. doi: 10.3389/fgene.2019.01080
Developmental stage-specific distribution of macrophages in mouse mammary gland
Stewart, Teneale A., Hughes, Katherine, Hume, David A. and Davis, Felicity M. (2019). Developmental stage-specific distribution of macrophages in mouse mammary gland. Frontiers in Cell and Developmental Biology, 7 250, 250. doi: 10.3389/fcell.2019.00250
Balic, Adam, Chintoan-Uta, Cosmin, Vohra, Prerna, Sutton, Kate M., Cassady-Cain, Robin L., Hu, Tuan, Donaldson, David S., Stevens, Mark P., Mabbott, Neil A., Hume, David A., Sang, Helen M. and Vervelde, Lonneke (2019). Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian m cells in the avian follicle-associated epithelium. Frontiers in Immunology, 10 (OCT) 2495, 2495. doi: 10.3389/fimmu.2019.02495
Salavati, Mazdak, Bush, Stephen J., Palma-Vera, Sergio, McCulloch, Mary E. B., Hume, David A. and Clark, Emily L. (2019). Elimination of reference mapping bias reveals robust immune related allele-specific expression in crossbred sheep. Frontiers in Genetics, 10 863, 863. doi: 10.3389/fgene.2019.00863
Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds
Hume, David A., Gutowska‐Ding, Maria W., Garcia‐Morales, Carla, Kebede, Adebabay, Bamidele, Oladeji, Trujillo, Adriana Vallejo, Gheyas, Almas A. and Smith, Jacqueline (2019). Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds. Journal of Leukocyte Biology, 107 (2) JLB.6MA0519-172R, 237-250. doi: 10.1002/jlb.6ma0519-172r
Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r
Assembly of a parts list of the human mitotic cell cycle machinery
Giotti, Bruno, Chen, Sz-Hau, Barnett, Mark W., Regan, Tim, Ly, Tony, Wiemann, Stefan, Hume, David A. and Freeman, Tom C. (2019). Assembly of a parts list of the human mitotic cell cycle machinery. Journal of Molecular Cell Biology, 11 (8), 703-718. doi: 10.1093/jmcb/mjy063
Phenotypic impacts of CSF1R deficiencies in humans and model organisms
Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019). Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, 107 (2) JLB.MR0519-143R, 205-219. doi: 10.1002/jlb.mr0519-143r
Rojo, Rocío, Raper, Anna, Ozdemir, Derya D., Lefevre, Lucas, Grabert, Kathleen, Wollscheid-Lengeling, Evi, Bradford, Barry, Caruso, Melanie, Gazova, Iveta, Sánchez, Alejandra, Lisowski, Zofia M., Alves, Joana, Molina-Gonzalez, Irene, Davtyan, Hayk, Lodge, Rebecca J., Glover, James D., Wallace, Robert, Munro, David A. D., David, Eyal, Amit, Ido, Miron, Véronique E., Priller, Josef, Jenkins, Stephen J., Hardingham, Giles E., Blurton-Jones, Mathew, Mabbott, Neil A., Summers, Kim M., Hohenstein, Peter, Hume, David A. and Pridans, Clare (2019). Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications, 10 (1) 3215, 3215. doi: 10.1038/s41467-019-11053-8
Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J., Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2019). Erratum: Pleiotropic impacts of macrophage ands microglial deficiency on development in rats with targeted mutation of the Csf1r locus (Journal of Immunology (2019) 201 (2683-2699) DOI: 10.4049/jimmunol.1701783). Journal of Immunology, 202 (11), 3334-3335. doi: 10.4049/jimmunol.1900420
Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait
Chundru, V. Kartik, Marioni, Riccardo E., Prendergast, James G. D., Vallerga, Costanza L., Lin, Tian, Berveridge, Allan J., SGPD Consortium, Gratten, Jacob, Hume, David A., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2019). Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait. Genetics, 212 (3), 577-586. doi: 10.1534/genetics.118.301861
Gow, Debbie J., Jackson, Hilary, Forsythe, Peter, Gow, Adam G., Mellanby, Richard J., Hume, David A. and Nuttall, Tim (2019). Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis. Veterinary Dermatology, 30 (2), 115-e32. doi: 10.1111/vde.12721
Karagianni, Anna E., Summers, Kim M., Couroucé, Anne, Depecker, Marianne, McGorum, Bruce C., Hume, David A. and Pirie, R. Scott (2019). The effect of race training on the basal gene expression of alveolar macrophages derived from Standardbred racehorses. Journal of Equine Veterinary Science, 75, 48-54. doi: 10.1016/j.jevs.2019.01.010
Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2019). Correction to: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Nature Immunology, (2018), 19, 6, (625-635), 10.1038/s41590-018-0111-5). Nature Immunology, 20 (3), 373-373. doi: 10.1038/s41590-019-0328-y
Prendergast, James G D, Pugh, Carys, Harris, Sarah E., Hume, David A., Deary, Ian J. and Beveridge, Allan (2019). Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution. Genome Biology and Evolution, 11 (3), 759-775. doi: 10.1093/gbe/evz014
Relatively hyperbolic groups with fixed peripherals
Cordes, Matthew and Hume, David (2019). Relatively hyperbolic groups with fixed peripherals. Israel Journal of Mathematics, 230 (1), 443-470. doi: 10.1007/s11856-019-1830-5
Causes and consequences of innate immune dysfunction in cirrhosis
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 (FEB) 293, 293. doi: 10.3389/fimmu.2019.00293
Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R
Hu, Tuanjun, Wu, Zhiguang, Bush, Stephen J., Freem, Lucy, Vervelde, Lonneke, Summers, Kim M., Hume, David A., Balic, Adam and Kaiser, Pete (2019). Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R. The Journal of Immunology, 202 (4), 1186-1199. doi: 10.4049/jimmunol.1800504
Bush, Stephen J., McCulloch, Mary E. B., Muriuki, Charity, Salavati, Mazdak, Davis, Gemma M., Farquhar, Iseabail L., Lisowski, Zofia M., Archibald, Alan L., Hume, David A. and Clark, Emily L. (2019). Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression. G3: Genes, Genomes, Genetics, 9 (2), 359-373. doi: 10.1534/g3.118.200810
The mononuclear phagocyte system: the relationship between monocytes and macrophages
Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019). The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 (2), 98-112. doi: 10.1016/j.it.2018.11.007
Low, Wai Yee, Tearle, Rick, Bickhart, Derek M., Rosen, Benjamin D., Kingan, Sarah B., Swale, Thomas, Thibaud-Nissen, Françoise, Murphy, Terence D., Young, Rachel, Lefevre, Lucas, Hume, David A., Collins, Andrew, Ajmone-Marsan, Paolo, Smith, Timothy P. L. and Williams, John L. (2019). Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity. Nature Communications, 10 (1) 260. doi: 10.1038/s41467-018-08260-0
A gene expression atlas of the domestic water buffalo (Bubalus bubalis)
Young, Rachel, Lefevre, Lucas, Bush, Stephen J., Joshi, Akshay, Singh, Salam H., Jadhav, Santosh K., Lisowski, Zofia M., Iamartino, Daniela, Summers, Kim M., Williams, John L., Archibald, Alan L., Gokhale, Suresh, Kumar, Satish and Hume, David A. (2019). A gene expression atlas of the domestic water buffalo (Bubalus bubalis). Frontiers in Genetics, 10 (JUN) 668. doi: 10.3389/fgene.2019.00668
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 (APR) 818, 818. doi: 10.3389/fimmu.2019.00818
Negative curvature in graphical small cancellation groups
Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2019). Negative curvature in graphical small cancellation groups. Groups, Geometry, and Dynamics, 13 (2), 579-632. doi: 10.4171/GGD/498
A chicken bioreactor for efficient production of functional cytokines
Herron, Lissa R., Pridans, Clare, Turnbull, Matthew L., Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A., Gill, Andrew C. and Sang, Helen M. (2018). A chicken bioreactor for efficient production of functional cytokines. BMC Biotechnology, 18 (1) 82. doi: 10.1186/s12896-018-0495-1
Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken
Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Riggio, Valentina, Matika, Oswald, Harman, Kimberley, Hocking, Paul M., Bumstead, Nat, Hesketh, Pat, Archer, Andrew, Bishop, Stephen C., Kaiser, Pete, Tomley, Fiona M., Hume, David A., Smith, Adrian L., Blake, Damer P. and Psifidi, Androniki (2018). Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken. Frontiers in Genetics, 9 528, 528. doi: 10.3389/fgene.2018.00528
Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis
Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Psifidi, Androniki, Riggio, Valentina, Harman, Kimberley, Bishop, Stephen C., Kaiser, Pete, Abrahamsen, Mitchell S., Hawken, Rachel, Watson, Kellie A., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2018). Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis. Genetics Selection Evolution, 50 (1) 63, 63. doi: 10.1186/s12711-018-0433-7
Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Nirmal, Ajit J., Regan, Tim, Shih, Barbara B., Hume, David A., Sims, Andrew H. and Freeman, Tom C. (2018). Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunology Research, 6 (11), 1388-1400. doi: 10.1158/2326-6066.CIR-18-0342
ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages
Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246
Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J, Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2018). Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus. Journal of Immunology, 201 (9), 2683-2699. doi: 10.4049/jimmunol.1701783
Brown, S. M., Bush, S. J., Summers, K. M., Hume, D. A. and Lawrence, A. B. (2018). Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity. Behavioural Brain Research, 350, 6-15. doi: 10.1016/j.bbr.2018.05.015
The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages
Scott, Charlotte L., T'Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W. F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan and Guilliams, Martin (2018). The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages. Immunity, 49 (2), 312-+. doi: 10.1016/j.immuni.2018.07.004
Bush, Stephen J., Freem, Lucy, MacCallum, Amanda J., O'Dell, Jenny, Wu, Chunlei, Afrasiabi, Cyrus, Psifidi, Androniki, Stevens, Mark P., Smith, Jacqueline, Summers, Kim M. and Hume, David A. (2018). Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken. BMC Genomics, 19 (1) 594. doi: 10.1186/s12864-018-4972-7
Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663
Pandit, Ramesh J., Hinsu, Ankit T., Patel, Namrata V., Koringa, Prakash G., Jakhesara, Subhash J., Thakkar, Jalpa R., Shah, Tejas M., Limon, Georgina, Psifidi, Androniki, Guitian, Javier, Hume, David A., Tomley, Fiona M., Rank, Dharamshibhai N., Raman, M., Tirumurugaan, K. G., Blake, Damer P. and Joshi, Chaitanya G. (2018). Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing. Microbiome, 6 (1) 115. doi: 10.1186/s40168-018-0501-9
Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19 (6), 625-635. doi: 10.1038/s41590-018-0111-5
An update on equine postoperative ileus: definitions, pathophysiology and management
Lisowski, Z. M., Pirie, R. S., Blikslager, A. T., Lefebvre, D., Hume, D. A. and Hudson, N. P. H. (2018). An update on equine postoperative ileus: definitions, pathophysiology and management. Equine Veterinary Journal, 50 (3), 292-303. doi: 10.1111/evj.12801
Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome
Bush, Stephen J., Muriuki, Charity, McCulloch, Mary E. B., Farquhar, Iseabail L., Clark, Emily L. and Hume, David A. (2018). Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. Genetics Selection Evolution, 50 (1) 20. doi: 10.1186/s12711-018-0391-0
The preterm labor associated ADAMTS2 gene is induced by glucocorticoids
Jubb, Alasdair W., Hofer, Thomas P., Hume, David A. and Ziegler-Heitbrock, Loems (2018). The preterm labor associated ADAMTS2 gene is induced by glucocorticoids. American Journal of Obstetrics and Gynecology, 219 (1), 122-123. doi: 10.1016/j.ajog.2018.03.024
The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A. and Mabbott, Neil A. (2018). The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nature Communications, 9 (1) 1272, 1272. doi: 10.1038/s41467-018-03638-6
Hawley, Catherine A., Rojo, Rocio, Raper, Anna, Sauter, Kristin A., Lisowski, Zofia M., Grabert, Kathleen, Bain, Calum C., Davis, Gemma M., Louwe, Pieter A., Ostrowski, Michael C., Hume, David A., Pridans, Clare and Jenkins, Stephen J. (2018). Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system. Journal of Immunology, 200 (6), 2209-2223. doi: 10.4049/jimmunol.1701488
Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017
Baillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A. ... Hume, David A. (2018). Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 (3) e1005934, e1005934. doi: 10.1371/journal.pcbi.1005934
Regan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018). Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 (4), 681-692. doi: 10.1002/JLB.3A0617-261R
Leday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T., MRC Immunopsychiatry Consortium, Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert ... Henderson, Robbie (2018). Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biological Psychiatry, 83 (1), 70-80. doi: 10.1016/j.biopsych.2017.01.021
Young, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E.B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L. and Hume, David A. (2018). Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages. ImmunoHorizons, 2 (1), 27-37. doi: 10.4049/immunohorizons.1700073
Jubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017). Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 (11), 3022-3031. doi: 10.1016/j.celrep.2017.11.053
Hume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio and Pridans, Clare (2017). The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates. Scientific Reports, 7 (1) 17115, 1-10. doi: 10.1038/s41598-017-15999-x
Farro, Giovanna, Stakenborg, Michelle, Gomez-Pinilla, Pedro J., Labeeuw, Evelien, Goverse, Gera, Giovangiulio, Martina Di, Stakenborg, Nathalie, Meroni, Elisa, D'Errico, Francesca, Elkrim, Yvon, Laoui, Damya, Lisowski, Zofia M., Sauter, Kristin A., Hume, David A., Van Ginderachter, Jo A., Boeckxstaens, Guy E. and Matteoli, Gianluca (2017). CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. Gut, 66 (12), 2098-2109. doi: 10.1136/gutjnl-2016-313144
Groups with no coarse embeddings into hyperbolic groups
Hume, David and Sisto, Alessandro (2017). Groups with no coarse embeddings into hyperbolic groups. New York Journal of Mathematics, 23, 1657-1670. doi: 10.48550/arXiv.1702.03789
Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033
Macdonald, Sarah E., Nolan, Matthew J., Harman, Kimberley, Boulton, Kay, Hume, David A., Tomley, Fiona M., Stabler, Richard A. and Blake, Damer P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12 (9) e0184890, 1-17. doi: 10.1371/journal.pone.0184890
A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
Clark, Emily L., Bush, Stephen J., McCulloch, Mary E. B., Farquhar, Iseabail L., Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C. Bruce, Freeman, Tom C., Summers, Kim M., Archibald, Alan L. and Hume, David A. (2017). A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics, 13 (9) e1006997, e1006997. doi: 10.1371/journal.pgen.1006997
The genomic architecture of mastitis resistance in dairy sheep
Banos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., Schulze, G., Arsenos, G., Hume, D. A. and Psifidi, A. (2017). The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18 (1) 624, 1-18. doi: 10.1186/s12864-017-3982-1
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Bell, J. A., Kivimäki, M., Bullmore, E. T., Steptoe, A., Carvalho, L. A., Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zuszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil, Janssen, Wayne Drevets, Wittenberg, Gayle M., Sun, Yu, Jones, Declan, Bullmore, Edward, Khan, Shahid, Stylianou, Annie and Henderson, Robert B. (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry, 7 (8) e1208, e1208-e1208. doi: 10.1038/tp.2017.155
FANTOM5 CAGE profiles of human and mouse samples
Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112
Rojo, Rocio, Pridans, Clare, Langlais, David and Hume, David A. (2017). Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science, 131 (16), 2161-2182. doi: 10.1042/CS20170238
Summers, Kim M. and Hume, David A. (2017). Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. Journal of Leukocyte Biology, 102 (4), 1081-1092. doi: 10.1189/jlb.1A0417-150RR
Bush, Stephen J., McCulloch, Mary E.B., Summers, Kim M., Hume, David A. and Clark, Emily L. (2017). Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries. BMC Bioinformatics, 18 (1) 301, 1-12. doi: 10.1186/s12859-017-1714-9
Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions
Kwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017). Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 (MAR) 32. doi: 10.3389/fgene.2017.00032
Baillie, J. Kenneth, Arner, Erik, Daub, Carsten, De Hoon, Michiel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Faulkner, Geoffrey J., Wells, Christine A., Rehli, Michael, Pavli, Paul, Summers, Kim M., Hume, David A. and FANTOM Consortium (2017). Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease. PLoS Genetics, 13 (3) e1006641, 1-36. doi: 10.1371/journal.pgen.1006641
Hume, David (2017). A continuum of expanders. Fundamenta Mathematicae, 238 (2), 143-152. doi: 10.4064/fm101-11-2016
Characterizations of Morse quasi-geodesics via superlinear divergence and sublinear contraction
Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2017). Characterizations of Morse quasi-geodesics via superlinear divergence and sublinear contraction. Documenta Mathematica, 22 (2017), 1193-1224. doi: 10.25537/dm.2017v22.1193-1224
Embedding mapping class groups into a finite product of trees
Hume, David (2017). Embedding mapping class groups into a finite product of trees. Groups, Geometry, and Dynamics, 11 (2), 613-647. doi: 10.4171/GGD/410
Stability and the Morse boundary:
Cordes, Matthew and Hume, David (2017). Stability and the Morse boundary:. Journal of the London Mathematical Society, 95 (3), 963-988. doi: 10.1112/jlms.12042
Professor Pete Kaiser 1964-2016
Stevens, Mark, Vervelde, Lonneke and Hume, David (2016). Professor Pete Kaiser 1964-2016. Avian Pathology, 45 (6), 683-684. doi: 10.1080/03079457.2016.1251745
Psifidi, Androniki, Banos, Georgios, Matika, Oswald, Desta, Takele T., Bettridge, Judy, Hume, David A., Dessie, Tadelle, Christley, Rob, Wigley, Paul, Hanotte, Olivier and Kaiser, Pete (2016). Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes. Genetics Selection Evolution, 48 (1) 74. doi: 10.1186/s12711-016-0252-7
A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep
Pridans, Clare, Davis, Gemma M., Sauter, Kristin A., Lisowski, Zofia M., Corripio-Miyar, Yolanda, Raper, Anna, Lefevre, Lucas, Young, Rachel, McCulloch, Mary E., Lillico, Simon, Milne, Elspeth, Whitelaw, Bruce and Hume, David A. (2016). A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep. Journal of Immunology, 197 (6), 2297-2305. doi: 10.4049/jimmunol.1502336
Sauter, Kristin A., Waddell, Lindsey A., Lisowski, Zofia M., Young, Rachel, Lefevre, Lucas, Davis, Gemma M., Clohisey, Sara M., McCulloch, Mary, Magowan, Elizabeth, Mabbott, Neil A., Summers, Kim M. and Hume, David A. (2016). Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311 (3), G533-G547. doi: 10.1152/ajpgi.00116.2016
Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016). Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 (1), 7-16. doi: 10.1038/icb.2016.74
Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches
Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009
Comparative transcriptome analysis of equine alveolar macrophages
Karagianni, A. E., Kapetanovic, R., Summers, K. M., Mcgorum, B. C., Hume, D. A. and Pirie, R. S. (2016). Comparative transcriptome analysis of equine alveolar macrophages. Equine Veterinary Journal, 49 (3), 375-382. doi: 10.1111/evj.12584
Functional annotation of the T-cell immunoglobulin mucin family in birds
Hu, Tuanjun, Wu, Zhiguang, Vervelde, Lonneke, Rothwell, Lisa, Hume, David A. and Kaiser, Pete (2016). Functional annotation of the T-cell immunoglobulin mucin family in birds. Immunology, 148 (3), 287-303. doi: 10.1111/imm.12607
Transcriptional regulation and macrophage differentiation
Hume, David A., Summers, Kim M. and Rehli, Michael (2016). Transcriptional regulation and macrophage differentiation. Microbiology Spectrum, 4 (3) MCHD-0024-2015, 1-19. doi: 10.1128/microbiolspec.MCHD-0024-2015
Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages
Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023
Wu, Zhiguang, Hu, Tuanjun, Rothwell, Lisa, Vervelde, Lonneke, Kaiser, Pete, Boulton, Kay, Nolan, Matthew J., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2016). Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63, 206-212. doi: 10.1016/j.dci.2016.04.016
Jubb, Alasdair W., Young, Robert S., Hume, David A. and Bickmore, Wendy A. (2016). Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages. Journal of Immunology, 196 (2), 813-822. doi: 10.4049/jimmunol.1502009
The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens
Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P. M., Kuo, R., Smith, J., Hocking, P. M., Salmon, N., Jones, M. A., Hume, D. A., Banos, G., Stevens, M. P. and Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17 (293) 293. doi: 10.1186/s12864-016-2612-7
Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S. ... Hayashizaki, Yoshihide (2015). The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 (12) e1002315, e1002315. doi: 10.1371/journal.pbio.1002315
Stutchfield, Benjamin M., Antoine, Daniel J., Mackinnon, Alison C., Gow, Deborah J., Bain, Calum C., Hawley, Catherine A., Hughes, Michael J., Francis, Benjamin, Wojtacha, Davina, Man, Tak Y., Dear, James W., Devey, Luke R., Mowat, Alan M., Pollard, Jeffrey W., Park, B. Kevin, Jenkins, Stephen J., Simpson, Kenneth J., Hume, David A., Wigmore, Stephen J. and Forbes, Stuart J. (2015). CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology, 149 (7), 1896-1909. doi: 10.1053/j.gastro.2015.08.053
Robert, Christelle, Kapetanovic, Ronan, Beraldi, Dario, Watson, Mick, Archibald, Alan L. and Hume, David A. (2015). Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome. BMC Genomics, 16 (1) 970, 970.1-970.17. doi: 10.1186/s12864-015-2111-2
Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 (304) 304ra142, 1-10. doi: 10.1126/scitranslmed.aaa3863
The many alternative faces of macrophage activation
Hume, David A. (2015). The many alternative faces of macrophage activation. Frontiers in Immunology, 6 (JUL) 370. doi: 10.3389/fimmu.2015.00370
Immune surveillance of the lung by migrating tissue monocytes
Rodero, Mathieu P., Poupel, Lucie, Loyher, Pierre-Louis, Hamon, Pauline, Licata, Fabrice, Pessel, Charlotte, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2015). Immune surveillance of the lung by migrating tissue monocytes. eLife, 4 (JULY 2015) e07847, 1-23. doi: 10.7554/eLife.07847
Direct embeddings of relatively hyperbolic groups with optimal ℓp compression exponent
Hume, David (2015). Direct embeddings of relatively hyperbolic groups with optimal ℓp compression exponent. Journal fur die Reine und Angewandte Mathematik, 2015 (703), 147-172. doi: 10.1515/crelle-2013-0040
Plant breeding: UK bioscientists push for crop policy
Hume, David (2015). Plant breeding: UK bioscientists push for crop policy. Nature, 521 (7553), 423-423. doi: 10.1038/521423c
Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response
Aitken, Stuart, Magi, Shigeyuki, Alhendi, Ahmad M. N., Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Arner, Erik, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Khachigian, Levon M., Okada-Hatakeyama, Mariko, Semple, Colin A., FANTOM Consortium, Forrest, Alistair R. R., Sandelin, Albin, Daub, Carsten O., Wells, Christine, Hume, David A., Arner, Erik, Kawaji, Hideya, Summers, Kim M., Vitting-Seerup, Kristoffer, Carninci, Piero, Andersson, Robin, Hayashizaki, Yoshihide and Yumoto, Noriko (2015). Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response. PLoS Computational Biology, 11 (4) e1004217, e1004217. doi: 10.1371/journal.pcbi.1004217
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Arner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E. ... Hayashizaki, Yoshihide (2015). Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 (6225), 1010-1014. doi: 10.1126/science.1259418
Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells
Joshi, Anagha, Pooley, Christopher, Freeman, Tom C., Lennartsson, Andreas, Babina, Magda, Schmidl, Christian, Geijtenbeek, Teunis, Michoel, Tom, Severin, Jessica, Itoh, Masayoshi, Lassmann, Timo, Kawaji, Hideya, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair R. R., Rehli, Michael and Hume, David A. (2015). Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells. Journal of Leukocyte Biology, 97 (5), 985-995. doi: 10.1189/jlb.6TA1014-477RR
Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma
Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen M., Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., Van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. (2015). Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25 (5), 577-588. doi: 10.1016/j.cub.2014.12.059
A transcriptional perspective on human macrophage biology
Schultze, Joachim L., Freeman, Tom, Hume, David A. and Latz, Eicke (2015). A transcriptional perspective on human macrophage biology. Seminars in Immunology, 27 (1), 44-50. doi: 10.1016/j.smim.2015.02.001
Garceau, Valerie, Balic, Adam, Garcia-Morales, Carla, Sauter, Kristin A., McGrew, Mike J., Smith, Jacqueline, Vervelde, Lonneke, Sherman, Adrian, Fuller, Troy E., Oliphant, Theodore, Shelley, John A., Tiwari, Raksha, Wilson, Thomas L., Chintoan-Uta, Cosmin, Burt, Dave W., Stevens, Mark P., Sang, Helen M. and Hume, David A. (2015). The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor. BMC Biology, 13 (1) 12, 12.1-12.17. doi: 10.1186/s12915-015-0121-9
'Recognised veterinary practice' in the context of clinical field trials
Nanjiani, Ian, Hume, David, Fitzpatrick, Julie and Murray, John (2015). 'Recognised veterinary practice' in the context of clinical field trials. Veterinary Record, 176 (21), 552-552. doi: 10.1136/vr.h2718
Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages
Garcia-Morales, Carla, Nandi, Sunil, Zhao, Debiao, Sauter, Kristin A., Vervelde, Lonneke, McBride, Derek, Sang, Helen M., Clinton, Mike and Hume, David A. (2015). Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages. Journal of Immunology, 194 (5), 2338-2344. doi: 10.4049/jimmunol.1401982
Exome sequencing: current and future perspectives
Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan, Deeb, Nader and Watson, Mick (2015). Exome sequencing: current and future perspectives. G3: Genes, Genomes, Genetics, 5 (8), 1543-1550. doi: 10.1534/g3.115.018564
Identification of low-confidence regions in the pig reference genome (Sscrofa10.2)
Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan L., Deeb, Nader and Watson, Mick (2015). Identification of low-confidence regions in the pig reference genome (Sscrofa10.2). Frontiers in Genetics, 6 (NOV) 338. doi: 10.3389/fgene.2015.00338
Orthogonal forms of Kac-moody groups are acylindrically hyperbolic
Caprace, Pierre-Emmanuel and Hume, David (2015). Orthogonal forms of Kac-moody groups are acylindrically hyperbolic. Annales de l'Institut Fourier, 65 (6), 2613-2640. doi: 10.5802/aif.2998
Third Report on Chicken Genes and Chromosomes 2015:
Schmid, Michael, Smith, Jacqueline, Burt, David W., Aken, Bronwen L., Antin, Parker B., Archibald, Alan L., Ashwell, Chris, Blackshear, Perry J., Boschiero, Clarissa, Brown, C. Titus, Burgess, Shane C., Cheng, Hans H., Chow, William, Coble, Derrick J., Cooksey, Amanda, Crooijmans, Richard P. M. A., Damas, Joana, Davis, Richard V.N., De Koning, Dirk-Jan, Delany, Mary E., Derrien, Thomas, Desta, Takele T., Dunn, Ian C., Dunn, Matthew, Ellegren, Hans, Eöry, Lél, Erb, Ionas, Farré, Marta, Fasold, Mario ... Zhou, Huaijun (2015). Third Report on Chicken Genes and Chromosomes 2015:. Cytogenetic and Genome Research, 145 (2), 78-179. doi: 10.1159/000430927
Characterisation of a novel fc conjugate of macrophage colony-stimulating factor
Gow, Deborah J, Sauter, Kristin A., Pridans, Clare, Moffat, Lindsey, Sehgal, Anuj, Stutchfield, Ben M., Raza, Sobia, Beard, Philippa M., Tsai, Yi Ting, Bainbridge, Graeme, Boner, Pamela L., Fici, Greg, Garcia-Tapia, David, Martin, Roger A., Oliphant, Theodore, Shelly, John A., Tiwari, Raksha, Wilson, Thomas L., Smith, Lee B., Mabbott, Neil A. and Hume, David A. (2014). Characterisation of a novel fc conjugate of macrophage colony-stimulating factor. Molecular Therapy, 22 (9), 1580-1592. doi: 10.1038/mt.2014.112
Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115)
Moffat, L., Rothwell, L., Garcia-Morales, C., Sauter, K. A., Kapetanovic, R., Gow, D. J. and Hume, D. A. (2014). Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). Developmental and Comparative Immunology, 47 (1), 123-128. doi: 10.1016/j.dci.2014.07.001
Transcriptomic analysis of mononuclear phagocyte differentiation and activation
Hume, David A. and Freeman, Tom C. (2014). Transcriptomic analysis of mononuclear phagocyte differentiation and activation. Immunological Reviews, 262 (1), 74-84. doi: 10.1111/imr.12211
Garcia-Morales, Carla, Rothwell, Lisa, Moffat, Lindsey, Garceau, Valerie, Balic, Adam, Sang, Helen M., Kaiser, Pete and Hume, David A. (2014). Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells. Developmental and Comparative Immunology, 42 (2), 278-285. doi: 10.1016/j.dci.2013.09.011
Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Bain, Calum C., Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M., Davies, Claire L., Donaldson, David S., Renault, Kathleen, McColl, Barry W., Mowat, Alan M., Serrels, Alan, Frame, Margaret C., Mabbott, Neil A. and Hume, David A. (2014). The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration. PLoS ONE, 9 (8) e105429, 1-12. doi: 10.1371/journal.pone.0105429
Raza, Sobia, Barnett, Mark W., Barnett-Itzhaki, Zohar, Amit, Ido, Hume, David A. and Freeman, Tom C. (2014). Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. Journal of Leukocyte Biology, 96 (2), 167-183. doi: 10.1189/jlb.6HI0313-169R
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice
Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B. and Hume, David A. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 96 (2), 265-274. doi: 10.1189/jlb.2A0114-006R
Design and development of exome capture sequencing for the domestic pig (Sus scrofa)
Robert, Christelle, Fuentes-Utrilla, Pablo, Troup, Karen, Loecherbach, Julia, Turner, Frances, Talbot, Richard, Archibald, Alan L., Mileham, Alan, Deeb, Nader, Hume, David A. and Watson, Mick (2014). Design and development of exome capture sequencing for the domestic pig (Sus scrofa). BMC Genomics, 15 (1) 550. doi: 10.1186/1471-2164-15-550
Transcription and enhancer profiling in human monocyte subsets
Schmidl, Christian, Renner, Kathrin, Peter, Katrin, Eder, Ruediger, Lassmann, Timo, Balwierz, Piotr J., Itoh, Masayohshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Andreesen, Reinhard, Hume, David A., Hoffmann, Petra, Forrest, Alistair R. R., Kreutz, Marina P., Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014). Transcription and enhancer profiling in human monocyte subsets. Blood, 123 (17), e90-e99. doi: 10.1182/blood-2013-02-484188
An atlas of active enhancers across human cell types and tissues
Andersson, Robin, Gebhard, Claudia, Miguel-Escalada, Irene, Hoof, Ilka, Bornholdt, Jette, Boyd, Mette, Chen, Yun, Zhao, Xiaobei, Schmidl, Christian, Suzuki, Takahiro, Ntini, Evgenia, Arner, Erik, Valen, Eivind, Li, Kang, Schwarzfischer, Lucia, Glatz, Dagmar, Raithel, Johanna, Lilje, Berit, Rapin, Nicolas, Bagger, Frederik Otzen, Jørgensen, Mette, Andersen, Peter Refsing, Bertin, Nicolas, Rackham, Owen, Burroughs, A. Maxwell, Baillie, J. Kenneth, Ishizu, Yuri, Shimizu, Yuri, Furuhata, Erina ... Sandelin, Albin (2014). An atlas of active enhancers across human cell types and tissues. Nature, 507 (7493), 455-461. doi: 10.1038/nature12787
Transcriptional switching in macrophages associated with the peritoneal foreign body response
Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 (6), 518-526. doi: 10.1038/icb.2014.19
Network analysis reveals distinct clinical syndromes underlying acute mountain sickness
Hall, David P., MacCormick, Ian J. C., Phythian-Adams, Alex T., Rzechorzek, Nina M., Hope-Jones, David, Cosens, Sorrel, Jackson, Stewart, Bates, Matthew G. D., Collier, David J., Hume, David A., Freeman, Thomas, Thompson, A. A. Roger and Baillie, John Kenneth (2014). Network analysis reveals distinct clinical syndromes underlying acute mountain sickness. PLoS ONE, 9 (1) e81229, e81229. doi: 10.1371/journal.pone.0081229
Pridans, Clare, Lillico, Simon, Whitelaw, Bruce and Hume, David A. (2014). Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals. Molecular Therapy - Methods and Clinical Development, 1 14010, 14010. doi: 10.1038/mtm.2014.10
A promoter-level mammalian expression atlas
Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab ... Hayashizaki, Yoshihide (2014). A promoter-level mammalian expression atlas. Nature, 507 (7493), 462-470. doi: 10.1038/nature13182
Homeostasis in the mononuclear phagocyte system
Jenkins, Stephen J. and Hume, David A. (2014). Homeostasis in the mononuclear phagocyte system. Trends in Immunology, 35 (8), 358-367. doi: 10.1016/j.it.2014.06.006
Balic, Adam, Garcia-Morales, Carla, Vervelde, Lonneke, Gilhooley, Hazel, Sherman, Adrian, Garceau, Valerie, Gutowska, Maria W., Burt, David W., Kaiser, Pete, Hume, David A. and Sang, Helen M. (2014). Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage. Development, 141 (16), 3255-3265. doi: 10.1242/dev.105593
CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function
Pridans, Clare, Sauter, Kristin A., Baer, Kristin, Kissel, Holger and Hume, David A. (2013). CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function. Scientific Reports, 3 (1) 3013. doi: 10.1038/srep03013
Jenkins, Stephen J., Ruckerl, Dominik, Thomas, Graham D., Hewitson, James P., Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M., Hume, David A. and Allen, Judith E. (2013). IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. Journal of Experimental Medicine, 210 (11), 2477-2491. doi: 10.1084/jem.20121999
The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages
Karagianni, Anna E., Kapetanovic, Ronan, McGorum, Bruce C., Hume, David A. and Pirie, Scott R. (2013). The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages. Veterinary Immunology And Immunopathology, 155 (4), 219-228. doi: 10.1016/j.vetimm.2013.07.003
An expression atlas of human primary cells: inference of gene function from coexpression networks
Mabbott, Neil A., Baillie, J. K., Brown, Helen, Freeman, Tom C. and Hume, David A. (2013). An expression atlas of human primary cells: inference of gene function from coexpression networks. BMC Genomics, 14 (1) 632. doi: 10.1186/1471-2164-14-632
Jacquelin, Sébastien, Licata, Fabrice, Dorgham, Karim, Hermand, Patricia, Poupel, Lucie, Guyon, Elodie, Deterre, Philippe, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2013). CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice. Blood, 122 (5), 674-683. doi: 10.1182/blood-2013-01-480749
Embedding universal covers of graph manifolds in products of trees
Hume, David and Sisto, Alessandro (2013). Embedding universal covers of graph manifolds in products of trees. Proceedings of the American Mathematical Society, 141 (10), 3337-3340. doi: 10.1090/S0002-9939-2013-11669-2
The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide
Kapetanovic, Ronan, Fairbairn, Lynsey, Downing, Alison, Beraldi, Dario, Sester, David P., Freeman, Tom C., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2013). The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. Bmc Genomics, 14 (1) 581. doi: 10.1186/1471-2164-14-581
Doig, Tamasin N., Hume, David A., Theocharidis, Thanasis, Goodlad, John R., Gregory, Christopher D. and Freeman, Tom C. (2013). Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. BMC Genomics, 14 (1) 469. doi: 10.1186/1471-2164-14-469
Comparative analysis of monocyte subsets in the pig
Fairbairn, Lynsey, Kapetanovic, Ronan, Beraldi, Dario, Sester, David P., Tuggle, Chris K., Archibald, Alan L. and Hume, David A. (2013). Comparative analysis of monocyte subsets in the pig. Journal of Immunology, 190 (12), 6389-6396. doi: 10.4049/jimmunol.1300365
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
Dave, Richa K., Dinger, Marcel E., Andrew, Megan, Askarian-Amiri, Marjan, Hume, David A. and Kellie, Stuart (2013). Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli. PLoS One, 8 (6) e68306, e68306.1-e68306.13. doi: 10.1371/journal.pone.0068306
Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, DavidA., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Erratum: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis [Immunity 38 (2013) 79-91]. Immunity, 38 (5), 1073-1079. doi: 10.1016/j.immuni.2013.05.008
Structural and functional annotation of the porcine immunome
Dawson, Harry D., Loveland, Jane E., Pascal, Geraldine, Gilbert, James G. R., Uenishi, Hirohide, Mann, Katherine M., Sang, Yongming, Zhang, Jie, Carvalho-Silva, Denise, Hunt, Toby, Hardy, Matthew, Hu, Zhiliang, Zhao, Shu-Hong, Anselmo, Anna, Shinkai, Hiroki, Chen, Celine, Badaoui, Bouabid, Berman, Daniel, Amid, Clara, Kay, Mike, Lloyd, David, Snow, Catherine, Morozumi, T., Cheng, Ryan Pei-Yen, Bystrom, Megan, Kapetanovic, Ronan, Schwartz, John C., Kataria, Ranjit, Astley, Matthew ... Tuggle, Christopher K. (2013). Structural and functional annotation of the porcine immunome. BMC Genomics, 14 (1) 332, 332.1-332.16. doi: 10.1186/1471-2164-14-332
Can DCs be distinguished from macrophages by molecular signatures?
Hume, David A., Mabbott, Neil, Raza, Sobia and Freeman, Tom C. (2013). Can DCs be distinguished from macrophages by molecular signatures?. Nature Immunology, 14 (3), 187-189. doi: 10.1038/ni.2516
Gow, Deborah J., Garceau, Valerie, Pridans, Clare, Gow, Adam G., Simpson, Kerry E., Gunn-Moore, Danielle and Hume, David A. (2013). Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 61 (2), 630-638. doi: 10.1016/j.cyto.2012.11.014
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, David A., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity, 38 (1), 79-91. doi: 10.1016/j.immuni.2012.12.001
Sauter, Kristin A., Bouhlel, M. Amine, O'Neal, Julie, Sester, David P., Tagoh, Hiromi, Ingram, Richard M. I, Pridans, Clare, Bonifer, Constanze and Hume, David A. (2013). The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus. PLoS One, 8 (1) e54935, e54935. doi: 10.1371/journal.pone.0054935
Gow, Deborah J., Garceau, Valerie, Kapetanovic, Ronan, Sester, David P., Fici, Greg J., Shelly, John A., Wilson, Thomas L. and Hume, David A. (2012). Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34. Cytokine, 60 (3), 793-805. doi: 10.1016/j.cyto.2012.08.008
A gene expression atlas of the domestic pig
Freeman, Tom C., Ivens, Alasdair, Baillie, J. Kenneth, Beraldi, Dario, Barnett, Mark W., Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I., Summers, Kim M., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2012). A gene expression atlas of the domestic pig. BMC Biology, 10 (9) 90. doi: 10.1186/1741-7007-10-90
Ahanda, Marie-Laure Endale, Fritz, Eric R., Estelle, Jordi, Hu, Zhi-Liang, Madsen, Ole, Groenen, Martien A. M., Beraldi, Dario, Kapetanovic, Ronan, Hume, David A., Rowland, Robert R. R., Lunney, Joan K., Rogel-Gaillard, Claire, Reecy, James M. and Giuffra, Elisabetta (2012). Prediction of altered 3 '-UTR miRNA-binding sites from RNA-seq data: the swine leukocyte antigen complex (SLA) as a model region. Plos One, 7 (11), e48607.1-e48607.11. doi: 10.1371/journal.pone.0048607
Hume, David A. (2012). Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes. Journal of Leukocyte Biology, 92 (3), 433-444. doi: 10.1189/jlb.0312166
Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109
IFITM3 restricts the morbidity and mortality associated with influenza
Everitt, Aaron R., Clare, Simon, Pertel, Thomas, John, Sinu P., Wash, Rachael S., Smith, Sarah E., Chin, Christopher R., Feeley, Eric M., Sims, Jennifer S., Adams, David J., Wise, Helen M., Kane, Leanne, Goulding, David, Digard, Paul, Anttila, Verneri, Baillie, J. Kenneth, Walsh, Tim S., Hume, David A., Palotie, Aarno, Xue, Yali, Colonna, Vincenza, Tyler-Smith, Chris, Dunning, Jake, Gordon, Stephen B., Smyth, Rosalind L., Openshaw, Peter J., Dougan, Gordon, Brass, Abraham L. and Kellam, Paul (2012). IFITM3 restricts the morbidity and mortality associated with influenza. Nature, 484 (7395), 519-523. doi: 10.1038/nature10921
Kapetanovic, Ronan, Fairbairn, Lynsey, Beraldi, Dario, Sester, David P., Archibald, Alan L., Tuggle, Christopher K. and Hume, David A. (2012). Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. The Journal of Immunology, 188 (7), 3382-3394. doi: 10.4049/jimmunol.1102649
Hume, David A. and MacDonald, Kelli P. A. (2012). Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood, 119 (8), 1810-1820. doi: 10.1182/blood-2011-09-379214
Bradford, Barry M., Sester, David P., Hume, David A. and Mabbott, Neil A. (2011). Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. Immunobiology, 216 (11), 1228-1237. doi: 10.1016/j.imbio.2011.08.006
Hume, David A. (2011). Editorial. Immunobiology, 216 (11), 1163-1. doi: 10.1016/j.imbio.2011.08.010
Macrophages.com: an on-line community resource for innate immunity research
Robert, Christelle, Lu, Xiang, Law, Andrew, Freeman, Tom C. and Hume, David A. (2011). Macrophages.com: an on-line community resource for innate immunity research. Immunobiology, 216 (11), 1203-1211. doi: 10.1016/j.imbio.2011.07.025
Somatic retrotransposition alters the genetic landscape of the human brain
Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan. Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A. and Faulkner, Geoffrey J. (2011). Somatic retrotransposition alters the genetic landscape of the human brain. Nature, 479 (7374), 534-537. doi: 10.1038/nature10531
Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses
Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher , Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A. and Ricardo, Sharon D. (2011). Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. The American Journal of Pathology, 179 (3), 1243-1256. doi: 10.1016/j.ajpath.2011.05.037
Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011). Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 (7), 1517-1532. doi: 10.1002/jbmr.354
Thomas, James A., Pope, Caroline, Wojtacha, Davina, Robson, Andrew J., Gordon-Walker, Timothy T., Hartland, Stephen, Ramachandran, Prakash, Van Deemter, Marielle, Hume, David A., Iredale, John P. and Forbes, Stuart J. (2011). Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology, 53 (6), 2003-2015. doi: 10.1002/hep.24315
Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P. and Hume, David A. (2011). The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. Journal of Leukocyte Biology, 89 (6), 855-871. doi: 10.1189/jlb.1110607
Hume, David A. (2011). Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. Journal of Leukocyte Biology, 89 (4), 525-538. doi: 10.1189/jlb.0810472
Roberts, Tara L., Dunn, Jasmyn A., Sweet, Matthew J., Hume, David A. and Stacey, Katryn J. (2011). The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. Molecular Immunology, 48 (8), 1027-1034. doi: 10.1016/j.molimm.2011.01.011
The future of animal production: improving productivity and sustainability
Hume, D. A., Whitelaw, C. B. A. and Archibald, A. L. (2011). The future of animal production: improving productivity and sustainability. Journal of Agricultural Science, 149 (S1), 9-16. doi: 10.1017/S0021859610001188
Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723
MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296
Summers, Kim M., Raza, Sobia, van Nimwegen, Erik, Freeman, Thomas C. and Hume, David A. (2010). Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome. European Journal of Human Genetics, 18 (11), 1209-1215. doi: 10.1038/ejhg.2010.91
CSF-1, IGF-1, and the control of postnatal growth and development
Gow, Deborah J., Sester, David P. and Hume, David A. (2010). CSF-1, IGF-1, and the control of postnatal growth and development. Journal of Leukocyte Biology, 88 (3), 475-481. doi: 10.1189/jlb.0310158
Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
Mabbott, Neil A., Baillie, J. Kenneth, Hume, David A. and Freeman, Tom C. (2010). Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology, 215 (9-10), 724-736. doi: 10.1016/j.imbio.2010.05.012
Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363
Hume, David A., Summers, Kim M., Raza, Sobia, Baillie, J. Kenneth and Freeman, Thomas C. (2010). Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations. Genomics, 95 (6), 328-338. doi: 10.1016/j.ygeno.2010.03.002
Ovchinnikov, Dmitry A., DeBats, Claire E. E., Sester, David P., Sweet, Matthew J. and Hume, David A. (2010). A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. Journal of Leukocyte Biology, 87 (5), 815-822. doi: 10.1189/jlb.0809557
Garceau, Valerie, Smith, Jacqueline, Paton, Ian R., Davey, Megan, Fares, Mario A., Sester, David P., Burt, David W. and Hume, David A. (2010). Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. Journal of Leukocyte Biology, 87 (5), 753-764. doi: 10.1189/jlb.0909624
Unravelling mononuclear phagocyte heterogeneity
Geissmann, Frederic, Gordon, Siamon, Hume, David A., Mowat, Allan M. and Randolph, Gwendalyn J. (2010). Unravelling mononuclear phagocyte heterogeneity. Nature Reviews Immunology, 10 (6), 453-460. doi: 10.1038/nri2784
An atlas of combinatorial transcriptional regulation in mouse and man
Ravasi, Timothy, Suzuki, Harukazu, Cannistraci, Carlo Vittorio, Katayama, Shintaro, Bajic, Vladimir B., Tan, Kai, Akalin, Altuna, Schmeier, Sebastian, Kanamori-Katayama, Mutsumi, Bertin, Nicolas, Carninci, Piero, Daub, Carsten O., Forrest, Alistair R.R., Gough, Julian, Grimmond, Sean, Han, Jung-Hoon, Hashimoto, Takehiro, Hide, Winston, Hofmann, Oliver, Kamburov, Atanas, Kaur, Mandeep, Kawaji, Hideya, Kubosaki, Atsutaka, Lassmann, Timo, van Nimwegen, Erik, MacPherson, Cameron Ross, Ogawa, Chihiro, Radovanovic, Aleksandar, Schwartz, Ariel ... Hayashizaki, Yoshihide (2010). An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 141 (2), 369. doi: 10.1016/j.cell.2010.04.004
Ripoll, Vera M., Kadioglu, Aras, Cox, Roger, Hume, David A. and Denny, Paul (2010). Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. Journal of Leukocyte Biology, 87 (4), 735-741. doi: 10.1189/jlb.0509359
An atlas of combinatorial transcriptional regulation in mouse and man
Ravasi, Timothy, Suzuki, Harukazu, Cannistraci, Carlo Vittorio, Katayama, Shintaro, Bajic, Vladimir B., Tan, Kai, Akalin, Altuna, Schmeier, Sebastian, Kanamori-Katayama, Mutsumi, Carninci, Piero, Bertin, Nicholas, Daub, Cartsten O., Forrest, Alistair R. R., Gough, Julian, Grimmond, Sean, Han, Jung-Hoon, Hashimoto, Takehiro, Hide, Winston, Hofmann, Oliver, Kamburov, Atanas, Kaur, Mandeep, Kawaji, Hideya, Kubosaki, Atsutaka, Lassmann, Timo, van Nimwegen, Erik, MacPherson, Cameron Ross, Ogawa, Chihiro, Radovanovic, Aleksandar, Schwartz, Ariel ... Hayashizaki, Yoshihide (2010). An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 140 (5), 744-752. doi: 10.1016/j.cell.2010.01.044
Deng, Lin, Zhou, Jin-Feng, Sellers, Rani S., Li, Jiu-Feng, Nguyen, Andrew V., Wang, Yubao, Orlofsky, Amos, Liu, Qiang, Hume, David A., Pollard, Jeffrey W., Augenlicht, Leonard and Lin, Elaine Y. (2010). A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. American Journal of Pathology, 176 (2), 952-967. doi: 10.2353/ajpath.2010.090622
Weber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010). Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 (2), 447-454. doi: 10.1016/j.ejmech.2009.10.025
Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response
Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010). Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 (1), 369-380. doi: 10.2353/ajpath.2010.090545
Forrest, A. R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., De Hoon, M. J.L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia, 24 (2), 460-466. doi: 10.1038/leu.2009.246
Lattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012
Summers, Kim M., Bokil, Nilesh J., Baisden, John M., West, Malcolm J., Sweet, Matthew J., Raggatt, Liza J. and Hume, David A. (2009). Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1. Genomics, 94 (4), 233-240. doi: 10.1016/j.ygeno.2009.06.005
Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration
Ebert, Stefanie, Weigelt, Karin, Walczak, Yana, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009). Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. Journal of Neurochemistry, 110 (6), 1863-1875. doi: 10.1111/j.1471-4159.2009.06286.x
Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)
Taft, Ryan J., Glazov, Evgeny A., Cloonan, Nicole, Simons, Cas, Stephen, Stuart, Faulkner, Geoffrey J., Lassmann, Timo, Forrest, Alistair R. R., Grimmond, Sean M., Schroder, Kate, Irvine, Katharine, Arakawa, Takahiro, Nakamura, Mari, Kubosaki, Atsutaka, Hayashida, Kengo, Kawazu, Chika, Murata, Mitsuyoshi, Nishiyori, Hiromi, Fukuda, Shiro, Kawai, Jun, Daub, Carsten O., Hume, David A., Suzuki, Harukazu, Orlando, Valerio, Carninci, Piero, Hayashizaki, Yoshihide and Mattick, John S. (2009). Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009). Nature Genetics, 41 (7), 859-859. doi: 10.1038/ng0709-859a
Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009). Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 (3), 326-337. doi: 10.1111/j.1365-2567.2008.02979.x
CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages
Dave, R. K., Hume, D. A., Elsegood, C and Kellie, S (2009). CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Experimental Cell Research, 315 (10), 1734-1744. doi: 10.1016/j.yexcr.2009.02.023
The regulated retrotransposon transcriptome of mammalian cells
Faulkner, Geoffrey J., Kimura, Yasumasa, Daub, Carsten O., Wani, Shivangi, Plessy, Charles, Irvine, Katharine M., Schroder, Kate, Cloonan, Nicole, Steptoe, Anita L., Lassmann, Timo, Waki, Kazunori, Hornig, Nadine, Arakawa, Takahiro, Takahashi, Hazuki, Kawai, Jun, Forrest, Alistair R. R., Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A., Orlando, Valerio, Grimmond, Sean M. and Carninci, Piero (2009). The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics, 41 (5), 563-571. doi: 10.1038/ng.368
Tiny RNAs associated with transcription start sites in animals
Taft, RJ, Glazov, EA, Cloonan, N, Simons, C, Stephen, S, Faulkner, GJ, Lassmann, T, Forrest, ARR, Grimmond, SM, Schroder, K, Irvine, K, Arakawa, T, Nakamura, M, Kubosaki, A, Hayashida, K, Kawazu, C, Murata, M, Nishiyori, H, Fukuda, S, Kawai, J, Daub, CO, Hume, DA, Suzuki, H, Orlando, V, Carninci, P, Hayashizaki, Y and Mattick, JS (2009). Tiny RNAs associated with transcription start sites in animals. Nature Genetics, 41 (5), 572-578. doi: 10.1038/ng.312
Data-driven normalization strategies for high-throughput quantitative RT-PCR
Mar, Jessica C., Kimura, Yasumasa, Schroder, Kate, Irvine, Katherine M., Hayashizaki, Yoshihide, Suzuki, Harukazu, Hume, David and Quackenbush, John (2009). Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics, 10 (1) 110, 110.1-110.10. doi: 10.1186/1471-2105-10-110
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009). The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 (4) R40. doi: 10.1186/gb-2009-10-4-r40
Severin, Jessica, Waterhouse, Andrew M., Kawaji, Hideya, Lassmann, Timo, van Nimwegen, Erik, Balwierz, Piotr J., de Hoon, Michiel J. L., Hume, David A., Carninci, Piero, Hayashizaki, Yoshihide, Suzuki, Harukazu, Daub, Carsten O. and Forrest, Alistair R. R. (2009). FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions. Genome Biology, 10 (4) R39. doi: 10.1186/gb-2009-10-4-r39
Auffray, Cedric, Fogg, Darin K., Narni-Mancinelli, Emilie, Senechal, Brigitte, Trouillet, Celine, Saederup, Noah, Leemput, Julia, Bigot, Karine, Campisi, Laura, Abitbol, Marc, Molina, Thierry, Charo, Israel, Hume, David A., Cumano, Ana, Lauvau, Gregoire and Geissmann, Frederic (2009). CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. Journal of Experimental Medicine, 206 (3), 595-606. doi: 10.1084/jem.20081385
TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium
Trieu, Angela, Bokil, Nilesh, Dunn, Jasmyn A., Roberts, Tara L., Xu, Damo, Liew, Foo Y., Hume, David A., Stacey, Katryn J. and Sweet, Matthew J. (2009). TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium. Immunology and Cell Biology, 87 (3), 218-225. doi: 10.1038/icb.2008.95
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009). HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 (5917), 1057-1060. doi: 10.1126/science.1169841
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009). Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 (2), 278-288. doi: 10.1189/jlb.0808497
Our evolving knowledge of the transcriptional landscape
Hume, David A. (2008). Our evolving knowledge of the transcriptional landscape. Mammalian Genome, 19 (10-12), 663-666. doi: 10.1007/s00335-008-9140-y
Faulkner, G. J., Forrest, A. R. R., Chalk, A. M., Schroder, K., Hayashizaki, Y., Carninci, P., Hume, D. A. and Grimmond, S. M. (2008). A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics, 91 (3), 281-288. doi: 10.1016/j.ygeno.2007.11.003
Macrophages as APC and the dendritic cell myth
Hume, David A. (2008). Macrophages as APC and the dendritic cell myth. Journal of Immunology, 181 (9), 5829-5835. doi: 10.4049/jimmunol.181.9.5829
Osteal macrophages: A new twist on coupling during bone dynamics
Pettit, A. R., Chang, M. K., Hume, D. A. and Raggatt, L. J. (2008). Osteal macrophages: A new twist on coupling during bone dynamics. Bone, 43 (6), 976-982. doi: 10.1016/j.bone.2008.08.128
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78
Maeda, Norihiro, Nishiyori, Hiromi , Nakamura, Mari , Kawazu, Chika, Murata, Mitsuyoshi , Sano, Hiromi, Hayashida, Kengo, Fukuda, Shiro, Tagami, Michihira, Hasegawa, Akira, Murakami, Kayoko, Schroder, Kate, Irvine, Katharine, Hume, David A., Hayashizaki, Yoshihide, Carninci, Piero and Suzuki, Harukazu (2008). Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. BioTechniques, 45 (1), 95-97. doi: 10.2144/000112814
King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008). Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 (13), 5036-5043. doi: 10.1021/ac702277q
Cortactin adopts a globular conformation and bundles actin into sheets
Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200
Increased TNF expression in CD43++ murine blood monocytes
Burke, Bernard, Ahmad, Rasheedah, Staples, Karl J., Snowden, Roger, Kadioglu, Aras, Frankenberger, Marion, Hume, David A. and Ziegler-Heitbrock, Loems (2008). Increased TNF expression in CD43++ murine blood monocytes. Immunology Letters, 118 (2), 142-147. doi: 10.1016/j.imlet.2008.03.012
WellsChristineA, Salvage-JonesJudithA, LiXin, HitchensKelly, ButcherSuzanne, MurrayRachaelZ, Beckhouse, Anthony G., LoYu-Lan-Sandra, ManzaneroSilvia, CobboldChristian, SchroderKate, MaBo, OrrSally, StewartLauren, LebusDaniel, SobieszczukPeter, HumeDavidA, StowJennifer, BlanchardHelen, AshmanRobertB, RRich and MHogan (2008). The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology, 180 (11), 7404-7413. doi: 10.4049/jimmunol.180.11.7404
Hume, David A., Sasmono, Tedjo, Himes, S. Roy, Sharma, Sudarshana M., Bronisz, Agnieszka, Constantin, Myrna, Ostrowski, Michael C. and Ross, Ian L. (2008). The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. The Journal of Immunology, 180 (10), 6733-6742. doi: 10.4049/jimmunol.180.10.6733
Chang, Ming K., Raggatt, Liza-Jane, Alexander, Kylie A., Kuliwaba, Julia S., Fazzalari, Nicola L., Schroder, Kate, Maylin, Erin R., Ripoll, Vera M, Hume, David A. and Pettit, Allison R. (2008). Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo. The Journal of Immunology, 181 (2), 1232-1244. doi: 10.4049/jimmunol.181.2.1232
Expression analysis of G Protein-coupled receptors in mouse macrophages
Lattin, Jane E., Schroder, Kate, Su, Andrew I., Walker, John R., Zhang, Jie, Wiltshire, Tim, Saijo, Kaoru, Glass, Christopher K., Hume, David A., Kellie, Stuart and Sweet, Matthew J. (2008). Expression analysis of G Protein-coupled receptors in mouse macrophages. Immunome Research, 4 (5) 5, 5. doi: 10.1186/1745-7580-4-5
Pettit, Allison R., Hume, David A. and Raggatt, Liza-Jane (2008). Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats. Bone, 42 (4), 825-825. doi: 10.1016/j.bone.2007.12.217
Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity
Lang, P., Van Harmelen, V., Kaaman, M., Parini, P., Carneheim, C., Cassady, A. I., Hume, D. A., Andersson, G. and Arner, P. (2008). Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS One, 3 (3) e1713, e1713-e1713. doi: 10.1371/journal.pone.0001713
Ovchinnikov, Dmitry A., van Zuylen, Wendy J. M., DeBats, Claire E. E., Alexander, Kylie A., Kellie, Stuart and Hume, David A. (2008). Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. Journal of Leukocyte Biology, 83 (2), 430-433. doi: 10.1189/jlb.0807585
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB
Ripoll, V. M, Meadows, N. A., Raggatt, L. J., Chang, M. K., Pettit, A. R., Cassady, A. I. and Hume, D. A. (2008). Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Gene, 413 (1-2), 32-41. doi: 10.1016/j.gene.2008.01.014
Hume, David A. (2008). Bring out your dead. Nature Immunology, 9 (1), 12-14. doi: 10.1038/ni0108-12
Differentiation and heterogeneity in the mononuclear phagocyte system
Hume, D. A. (2008). Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunology, 1 (6), 432-441. doi: 10.1038/mi.2008.36
Bonifer, Constanze and Hume, David A. (2008). The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Frontiers in Bioscience-Landmark, 13 (2), 549-560. doi: 10.2741/2700
Systems biology of transcription control in macrophages
Ravasi, Timothy, Wells, Christine A. and Hume, David A. (2007). Systems biology of transcription control in macrophages. BioEssays, 29 (12), 1215-1226. doi: 10.1002/bies.20683
McMorran, Brendan J., Patat, Severine A. Ouvry, Carlin, John B., Grimwood, Keith, Jones, Alun, Armstrong, David S., Galati, John C., Cooper, Peter J., Byrnes, Catherine A., Francis, Paul W., Robertson, Colin F., Hume, David A., Borchers, Christoph H., Wainwright, Claire E. and Wainwright, Brandon J. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53 (10), 1782-1791. doi: 10.1373/clinchem.2007.087650
Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 (6), 3495-3503. doi: 10.4049/jimmunol.179.6.3495
Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Katayama, Shintaro, Shimokawa, Kazuro, Ponjavic, Jasmina, Semple, Colin A. M., Taylor, Martin S., Engström, Pär G., Frith, Martin C., Forrest, Alistair R. R., Alkema, Wynand B., Tan, Sin Lam, Plessy, Charles, Kodzius, Rimantas, Ravasi, Timothy, Kasukawa, Takeya, Fukuda, Shiro, Kanamori-Katayama, Mutsumi, Kitazume, Yayoi, Kawaji, Hideya, Kai, Chikatoshi, Nakamura, Mari, Konno, Hideaki, Nakano, Kenji, Mottagui-Tabar, Salim, Arner, Peter, Chesi, Alessandra, Gustincich, Stefano ... Hayashizaki, Yoshihide (2007). Erratum: Genome-wide analysis of mammalian promoter architecture and evolution (Nature Genetics (2006) 38, (626-635)). Nature Genetics, 39 (9), 1174-1174. doi: 10.1038/ng0907-1174b
G-protein-coupled receptor expression, function, and signaling in macrophages
Lattin, J., Zidar, D., Schroder, K., Kellie, S., Hume, D. and Sweet, M. (2007). G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology, 82 (1), 16-32. doi: 10.1189/jlb.0107051
Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007). Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 (25), 10382-10387. doi: 10.1073/pnas.0700974104
The role of schlafen in macrophages and inflammation
van Zuijlen, WJM, Cook, AD, Ovchinnikov, DA, Kellie, S and Hume, DA (2007). The role of schlafen in macrophages and inflammation. Inflammation Research, 56, S389-S389.
Neutrophilic schizophrenia: Breaching the barrier between innate and adaptive immunity
Ferrante, Antonio, Hii, Charles and Hume, David (2007). Neutrophilic schizophrenia: Breaching the barrier between innate and adaptive immunity. Immunology and Cell Biology, 85 (4), 265-266. doi: 10.1038/sj.icb.7100036
Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007). PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 (6), 1577-1590. doi: 10.1189/jlb.0107036
Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007). Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 (10), 6557-6566. doi: 10.4049/jimmunol.178.10.6557
Meadows, Nicholas A., Sharma, Sudarshana M., Faulkner, Geoffrey J., Ostrowski, Michael C., Hume, David A. and Cassady, Alan I. (2007). The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. Journal of Biological Chemistry, 282 (3), 1891-1904. doi: 10.1074/jbc.M608572200
Rae, Fiona, Woods, Kyra, Sasmono, Tedjo, Campanale, Naomi, Taylor, Darrin, Ovchinnikov, Dmitry A., Grimmond, Sean M., Hume, David A., Ricardo, Sharon D. and Little, Melissa H. (2007). Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Developmental Biology, 308 (1), 232-246. doi: 10.1016/j.ydbio.2007.05.027
Hinshelwood, Rebecca A., Huschtscha, Lily I., Melki, John, Stirzaker, Clare, Abdipranoto, Andrea, Vissel, Bryce, Ravasi, Timothy, Wells, Christine A., Hume, David A., Reddel, Roger R. and Clark, Susan J. (2007). Concordant Epigenetic silencing of transforming growth factor -beta signalling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67 (24), 11517-11527. doi: 10.1158/0008-5472.CAN-07-1284
Bode, K. A., Schroder, K., Hume, D. A., Ravasi, T., Heeg, K., Sweet, M. J. and Dalpke, A. H. (2007). Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology, 122 (4), 596-606. doi: 10.1111/j.1365-2567.2007.02678.x
Mammalian RNA polymerase II core promoters: insights from genome-wide studies
Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y and Hume, DA (2007). Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews Genetics, 8 (6), 424-436. doi: 10.1038/nrg2026
Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., Cook, A. D., Himes, S. R., Hamilton, J. A. and Hume, D. A. (2007). Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. Journal of Leukocyte Biology, 82 (1), 111-123. doi: 10.1189/jlb.1206713
S100A8/S100A9 and their association with cartilage and bone
Zreiqat, H., Howlett, C.R., Gronthos, S., Hume, D. and Geczy, C.L. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38 (5), 381-391. doi: 10.1007/s10735-007-9117-2
Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J., Hume, D. A., Stacey, K. J. and Sweet, M. J. (2006). CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. Journal of Immunology, 177 (7), 4473-4480. doi: 10.4049/jimmunol.177.7.4473
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006). A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 (11), 1921-1923. doi: 10.1096/fj.06-5848fje
Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A. and Du, Hong (2006). Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal(-/-) mice. American Journal of Pathology, 169 (3), 916-926. doi: 10.2353/ajpath.2006.051327
Hume, David A. (2006). Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes". Journal of Immunology, 177 (4), 2035-2035. doi: 10.4049/jimmunol.177.4.2035
Transcriptional network dynamics in macrophage activation
Nilsson, Roland, Bajic, Vladimir B., Suzuki, Harukazu, di Bernardo, Diego, Bjorkegren, Johan, Katayama, Shintaro, Reid, James F., Sweet, Matthew J., Gariboldi, Manuela, Carninci, Piero, Hayashizaki, Yosihide, Hume, David A., Tegner, Jesper and Ravasi, Timothy (2006). Transcriptional network dynamics in macrophage activation. Genomics, 88 (2), 133-142. doi: 10.1016/j.ygeno.2006.03.022
Mice and men: Their promoter properties
Bajic, Vladimir B., Tan, Sin Lam, Christoffels, Alan, Schonbach, Christian, Lilpovich, Leonard, Yang, Liang, Hofmann, Oliver, Kruger, Adele, Hide, Winston, Kai, Chikatoshi, Kawai, Jun, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2006). Mice and men: Their promoter properties. Plos Genetics, 2 (4) e54, 614-626. doi: 10.1371/journal.pgen.0020054
Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs
Maeda, Norihiro, Kasukawa,Takeya, Frith, Martin, Aturaliya, Rajith N., Forrest, Alistair R. R., Ravasi,Timothy, Teasdale, Rohan D., Wells, Christine A., Hume,David A. and Hayashizaki,Yoshihide (2006). Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs. PLoS Genetics, 2 (4) e62, 498-503. doi: 10.1371/journal.pgen.0020062
Alternate transcription of the Toll-like receptor signaling cascade
Wells, C. A., Chalk, A. M., Forrest, A., Taylor, D., Waddell, N., Schroder, K., Himes, S. R., Faulkner, G., Lo, S., Kasukawa, T., Kawaji, H., Kai, C., Kawai, J., Katayama, S., Carninci, P., Hayashizaki, Y., Hume, D. A. and Grimmond, S. M. (2006). Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology, 7 (2) R10, R10.1-R10.17. doi: 10.1186/gb-2006-7-2-r10
The JNK are important for development and survival of macrophages
Himes, S. Roy, Sester, David P., Ravasi, Timothy, Cronau, Stephen L., Sasmono, Tedjo and Hume, David A. (2006). The JNK are important for development and survival of macrophages. Journal Of Immunology, 176 (4), 2219-2228. doi: 10.4049/jimmunol.176.4.2219
Hume, David and Hertzog, Paul (2006). Innate immunity. Current Opinion in Immunology, 18 (1), 1-2. doi: 10.1016/j.coi.2005.11.016
An automatable screen for the rapid identification of proteins amenable to refolding
Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056
Apoptotic cell removal in development and tissue homeostasis
Henson, P. M. and Hume, D. A. (2006). Apoptotic cell removal in development and tissue homeostasis. Trends In Immunology, 27 (5), 244-250. doi: 10.1016/j.it.2006.03.005
Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes
Brahmachary, M., Schonbach, C., Yang, L., Huang, E. L., Tan, S. L., Chowdhary, R., Krishnan, S. P. T., Lin, C. Y., Hume, D. A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y. and Bajic, V. B. (2006). Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. Bmc Bioinformatics, 7 (Supp. 5) S8, Article number S8. doi: 10.1186/1471-2105-7-S5-S8
Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006). Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62, 133-135. doi: 10.1107/S17443091060000030
Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., Fukuda, S., Ru, K., Frith, M., Gongora, M., Grimmond, S., Hume, D. A., Hayashizaki, Y. and Mattick, J. S. (2006). Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Research, 16 (1), 11-19. doi: 10.1101/gr.4200206
Focusing in on structural genomics: The University of Queensland structural biology pipeline
Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002
Sharma, S. M., Hu, R., Bronisz, A., Meadows, N., Lusby, T., Fletcher, B., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2006). Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks. Critical Reviews In Eukaryotic Gene Expression, 16 (3), 253-277. doi: 10.1615/critreveukargeneexpr.v16.i3.40
Genome-wide analysis of mammalian promoter architecture and evolution
Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Frith, Martin C., Forrest, Alistair R. R., Ravasi, Timothy, Grimmond, Sean M., Wells, Christine A., Hume, David A. and Hayashizaki, Yoshihide (2006). Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics, 38 (6), 626-635. doi: 10.1038/ng1789
Inoue, Kenji, Kobayashi, Mika, Yano, Kiichiro, Miura, Mai, Izumi, Akashi, Mataki, Chikage, Doi, Takeshi, Hamakubo, Takao, Reid, Patrick C., Hume, David A., Yoshida, Minoru, Aird, William C., Kodama, Tatsuhiko and Minami, Takashi (2006). Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression. Arteriosclerosis Thrombosis And Vascular Biology, 26 (12), 2652-2659. doi: 10.1161/01.ATV.0000247247.89787.e7
Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase
Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031
Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins
Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006
Aung, H. T., Schroder, K., Himes, S. R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D. A., Sweet, M. J. and Ravasi, T. (2006). LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Faseb Journal, 20 (9), 1315-1327. doi: 10.1096/fj.05-5360com
Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070
Wu, Andy C. K., Grondahl, Lisbeth, Jack, Kevin S., Foo, Michelle X., Trau, Matt, Hume, David A. and Cassady, Alan I. (2006). Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Biomaterials, 27 (27), 4715-4725. doi: 10.1016/j.biomaterials.2006.05.010
Signal integration between IFN gamma and TLR signalling pathways in macrophages
Schroder, K., Sweet, M. J. and Hume, D. A. (2006). Signal integration between IFN gamma and TLR signalling pathways in macrophages. Immunobiology, 211 (6-8), 511-524. doi: 10.1016/j.imbio.2006.05.007
The mononuclear phagocyte system
Hume, D. A. (2006). The mononuclear phagocyte system. Current Opinion In Immunology, 18 (1), 49-53. doi: 10.1016/j.coi.2005.11.008
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction
Cochrane, Anita L., Kett, Michelle M., Samuel, Chrishan S., Campanale, Naomi V., Anderson, Warwick P., Hume, David A., Little, Melissa H., Bertram, John F. and Ricardo, Sharon D. (2005). Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. Journal of The American Society of Nephrology, 16 (12), 3623-3630. doi: 10.1681/ASN.2004090771
Therapeutic targets in inflammatory disease
Hume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923
The transcriptional landscape of the mammalian genome
The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005). The transcriptional landscape of the mammalian genome. Science, 309 (5740), 1559-1563. doi: 10.1126/science.1112014
MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005). The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 (3), 1399-1405. doi: 10.4049/jimmunol.175.3.1399
Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013
Antisense transcription in the mammalian transcriptome
RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005). Antisense transcription in the mammalian transcriptome. Science, 309 (5740), 1564-1566. doi: 10.1126/science.1112009
Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005). Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 (2), 605-608. doi: 10.4049/jimmunol.174.2.605
Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides
Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005). Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 (6), 3569-3576. doi: 10.4049/jimmunol.175.6.3569
Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.
Ripoll, V. M., Hume, D. A. and Fontanilla, M.R. (2005). Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.. Biomedica, 25 (2), 261-270. doi: 10.7705/biomedica.v25i2.1348
Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation
Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005). Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 (2), 154-164. doi: 10.1016/j.abb.2005.05.013
Inflammation suppressor genes: please switch out all the lights
Wells, C. A., Ravasi, T. and Hume, D. A. (2005). Inflammation suppressor genes: please switch out all the lights. Journal of Leukocyte Biology, 78 (1), 9-13. doi: 10.1189/jlb.1204710
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action
Sester, D. P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J. A., McDonald, R. C., Ripoll, V., Wells, C. A., Suzuki, H., Hayashizaki, Y., Stacey, K. J., Hume, D. A. and Sweet, M. J. (2005). LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology, 210 (2-4), 97-107. doi: 10.1016/j.imbio.2005.05.004
Raisanen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A. and Vaananen, H. K. (2005). Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing. Biochemical And Biophysical Research Communications, 331 (1), 120-126. doi: 10.1016/j.bbrc.2005.03.133
Modification of recombinatorial cloning for small affinity tag fusion protein construct generation
Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016
Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system
Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7
Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., Reynolds, E. C., Hume, D. A., Hamilton, J. A., Geczy, C. L. and Anderson, G. P. (2005). S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 4 (1), 136-145. doi: 10.1021/pr049829t
Murray, Rachael Z., Wylie, Fiona G., Khromykh, Tatiana, Hume, David A. and Stow, Jennifer L. (2005). Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha. Journal of Biological Chemistry, 280 (11), 10478-10483. doi: 10.1074/jbc.M414420200
Himes, S. R., Cronau, S., Mulford, C. and Hume, D. A. (2005). The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene, 24 (34), 5278-5286. doi: 10.1038/sj.onc.1208657
Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Sollner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., Hume, D. A. and Andreesen, R. (2005). Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of Immunology, 174 (11), 7111-7122. doi: 10.4049/jimmunol.174.11.7111
Tagoh, Hiromi, Schebesta, Alexandra, Lefevre, Pascal, Wilson, Nicola, Hume, David, Busslinger, Meinrad and Bonifer, Constanze (2004). Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. The EMBO Journal, 23 (21), 4275-4285. doi: 10.1038/sj.emboj.7600421
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008
Kasukawa, T., Katayama, S., Kawaji, H., Suzuki, H., Hume, D. A. and Hayashizaki, Y. (2004). Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis. Genomics, 84 (6), 913-921. doi: 10.1016/j.ygeno.2004.08.011
Interferon-gamma: an overview of signals, mechanisms and functions
Schroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004). Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 (2), 163-189. doi: 10.1189/jlb.0603252
Probing the S100 protein family through genomic and functional analysis
Ravasi, Timothy, Hsu, Kenneth, Goyette, Jesse, Schroder, Kate, Yang, Zheng, Rahimi, Farid, Miranda, Les P., Alewood, Paul F., Hume, David A. and Geczy, Carolyn (2004). Probing the S100 protein family through genomic and functional analysis. Genomics, 84 (1), 10-22. doi: 10.1016/j.ygeno.2004.02.002
Rasputin, more promiscuous than ever: a review of G3BP
Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004). Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 (10), 1065-1077. doi: 10.1387/ijdb.041893ki
McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D. and Wainwright, B. (2003). Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infection And Immunity, 71 (10), 6035-6044. doi: 10.1128/IAI.71.10.6035-6044.2003
Genetic control of the innate immune response
Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B. J. and Hume, D. A. (2003). Genetic control of the innate immune response. BMC Immunology, 4 (Article 5) 5, 1-18. doi: 10.1186/1471-2172-4-5
A guide to the mammalian genome
Okazaki, Yasushi and Hume, David A. (2003). A guide to the mammalian genome. Genome Research, 13 (6 B), 1267-1272. doi: 10.1101/gr.1445603
Zavolan, M., Kondo, S., Schonbach, C., Adachi, J., Hume, D. A., Hayashizaki, Y., Gaasterland, T., RIKEN GER Grp and GLS Members (2003). Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Research, 13 (6B), 1290-1300. doi: 10.1101/gr.1017303
Phosphoregulators: Protein kinases and protein phosphatases of mouse
Forrest, Alistair R. R., Ravasi, Timothy, Taylor, Darrin, Huber, Thomas L., Hume, David A., RIKEN GER Group, GSL Members and Grimmond, Sean (2003). Phosphoregulators: Protein kinases and protein phosphatases of mouse. Genome Research, 13 (6B), 1443-1454. doi: 10.1101/gr.954803
The molecular basis for the lack of immunostimulatory activity of vertebrate DNA
Stacey, Katryn J., Young, Greg R., Clark, Francis, Sester, David P., Roberts, Tara L., Naik, Shalin, Sweet, Matthew J. and Hume, David A. (2003). The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. Journal of Immunology, 170 (7), 3614-3620. doi: 10.4049/jimmunol.170.7.3614
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R. and Hume, D. A. (2003). A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 101 (3), 1155-1163. doi: 10.1182/blood-2002-02-1569
CSF-1 as a regulator of macrophage activation and immune responses
Sweet, MJ and Hume, DA (2003). CSF-1 as a regulator of macrophage activation and immune responses. Archivum Immunologiae Et Therapiae Experimentalis, 51 (3), 169-177.
Wells, C. A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Faulkner, G. J., Okazaki, Y., Quackenbush, J., Hume, D. A., RIKEN GER Group,, GSL Members, and Lyons, P. A. (2003). Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Research, 13 (6B), 1360-1365. doi: 10.1101/gr.1056103
Development and evaluation of an automated annotation pipeline and cDNA annotation system
Kasukawa, T., Furuno, M., Nikaido, I., Bono, H., Hume, D. A., Bult, C., Hill, D. P., Baldarelli, R., Gough, J., Kanapin, A., Matsuda, H., Schriml, L. M., Hayashizaki, Y., Okazaki, Y. and Quackenbush, J. (2003). Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Research, 13 (6B), 1542-1551. doi: 10.1101/gr.992803
Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome
Tajul Arifin, K., Teasdale, R. D., Ravasi, T., Hume, D. A., RIKEN GER Group,, GSL Members, and Mattick, J. S. (2003). Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Reaserch, 13 (6B), 1416-1429. doi: 10.1101/gr.1015703
Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection
Numata, K., Kanai, A., Saito, R., Kondo, S., Adachi, J., Wilming, L. G., Hume, D. A., RIKEN GER Group,, GSL Members,, Hayashizaki, Y. and Tomita, M. (2003). Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Research, 13 (6B), 1301-1306. doi: 10.1101/gr.1011603
Walsh, N. C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D. A. and Cassady, A. I. (2003). Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene, 307 (1-2), 111-123. doi: 10.1016/S0378-1119(03)00449-9
Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome
Ravasi, T., Huber, T. L., Zavolan, M., Forrest, A. R., Gaasterland, T., Grimmond, S. M., RIKEN GER Group,, GSL Members, and Hume, D. A. (2003). Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome. Genome Research, 13 (6B), 1430-1442. doi: 10.1101/gr.949803
Grimmond, Sean M., Miranda, Kevin C., Yuan, Zheng, Davis, Melissa J., Hume, David A., Yagi, Ken, Tominaga, Naoko, Bono, Hidemasa, Hayashizaki, Yoshihide, Okazaki, Yasushi, RIKEN GER Group,, GSL Members, and Teasdale, Rohan D. (2003). The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Research, 13 (6B), 1350-1359. doi: 10.1101/gr.983703
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
Teasdale, R. D., Hume, D. A., Yuan, Zheng and The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team (2002). Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420 (6915), 563-573. doi: 10.1038/nature01266
Oceandy, Delvac, McMorran, Brendan J., Smith, Stephen N., Schreiber, Rainer, Kunzelmann, Karl, Alton, Eric W. F. W., Hume, David A. and Wainwright, Brandon J. (2002). Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics, 11 (9), 1059-1067. doi: 10.1093/hmg/11.9.1059
NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells
Xie, Y., Chen, C. M., Stevenson, M. A., Hume, D. A., Auron, P. E. and Calderwood, S. K. (2002). NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochemical And Biophysical Research Communications, 291 (4), 1071-1080. doi: 10.1006/bbrc.2002.6562
Ravasi, Timothy, Wells, Christine, Forrest, Alistair, Underhill., David M., Wainwright, Brandon J., Aderem, Alan, Grimmond, Sean and Hume, David A. (2002). Erratum: Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes (The Journal of Immunology (2002) 168 (44-50)). Journal of Immunology, 168 (3)
Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., Hume, David A. and Liew, Foo Y. (2002). Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. Journal of Immunology, 168 (1), 392-399. doi: 10.4049/jimmunol.168.1.392
Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S. and Hume, D. A. (2002). Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes. Journal of Immunology, 168 (1), 44-50. doi: 10.4049/jimmunol.168.1.44
Wardrop, S. L., Wells, C., Ravasi, T., Hume, D. A. and Richardson, D. R. (2002). Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism. Journal of Leukocyte Biology, 71 (1), 99-106. doi: 10.1189/jlb.71.1.99
Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. and Ostrowski, M. C. (2002). The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts. Journal of Leukocyte Biology, 71 (2), 295-303. doi: 10.1189/jlb.71.2.295
Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. and Ostrowski, M. C. (2002). The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. Journal of Leukocyte Biology, 71 (2), 304-310. doi: 10.1189/jlb.71.2.304
The mononuclear phagocyte system revisited
Hume, David A., Ross, Ian L., Himes, S. Roy, Sasmono, R. Tedjo, Wells, Christine A. and Ravasi, Timothy (2002). The mononuclear phagocyte system revisited. Journal of Leukocyte Biology, 72 (4), 621-627. doi: 10.1189/jlb.72.4.621
Tagoh, H., Himes, R., Clarke, D., Leenen, P. J. M., Riggs, A. D., Hume, D. and Bonifer, C. (2002). Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes and Development, 16 (13), 1721-1737. doi: 10.1101/gad.222002
A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression
Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, T., Oceandy, D., Clark, R., Bonifer, C. and Hume, D. A. (2001). A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. Journal of Leukocyte Biology, 70 (5), 812-820. doi: 10.1189/jlb.70.5.812
Mcmorran, B., Palmer, J., Lunn, D., Oceandy, D., Costelloe, E. O., Thomas, G., Hume, D. A. and Wainwright, B. J. (2001). G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. AJP-Lung Cellular and Molecular Physiology, 281 (3), 740-747. doi: 10.1152/ajplung.2001.281.3.L740
Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2001). Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. Journal of Biological Chemistry, 276 (39), 36703-36710. doi: 10.1074/jbc.M106418200
Hume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A.O., Liew, F.Y. and Aderem, A. (2001). Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunology, 2 (11) 11, 1-12. doi: 10.1186/1471-2172-2-11
Structural genomics: Protein structures for the masses?
Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001). Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 (2), 13-16.
Transcriptional regulation of c-fms gene expression
Xie, Y., Chen, C. M. and Hume, D. A. (2001). Transcriptional regulation of c-fms gene expression. Cell Biochemistry And Biophysics, 34 (1), 1-16. doi: 10.1385/CBB:34:1:001
Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene
Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A., Sester, D., Mignotte, B. and Jeannin, J. F. (2000). Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14 (15), 2393-2395. doi: 10.1096/fj.98-0509fje
Structure, function and regulation of tartrate-resistant acid phosphatase
Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9
G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000). G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 (7), 3870-3877. doi: 10.4049/jimmunol.164.7.3870
Dwidedi, P. P., Omdahl, J. L., Kola, I., Hume, D. A. and Kay, B. K. (2000). Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP024) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-hihyroxyvitamin D3 mediated induction. Journal of Biological Chemistry, 275 (1), 47-55. doi: 10.1074/jbc.275.1.47
Co-operative induction of pro-inflammatory signaling by Toll-like receptors
Ozinsky, A., Smith, K. D., Hume, D. and Underhill, D. M. (2000). Co-operative induction of pro-inflammatory signaling by Toll-like receptors. Journal of Endotoxin Research, 6 (5), 393-396. doi: 10.1177/09680519000060051101
Smith, James L., Schaffner, Alicia E., Hofmeister, Joseph K., Hartman, Matthew Hartman, Wei, Guo, Forsthoefel, David, Hume, David A. and Ostrowski, Michael C. (2000). Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Molecular and Cellular Biology, 20 (21), 8026-8034. doi: 10.1128/MCB.20.21.8026-8034.2000
Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene
Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A. and Sester, D. (2000). Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. The FASEB Journal, 15 (15), 2393-2395.
Aderem, A. and Hume, D. A. (2000). How do you see CG. Cell, 103 (7), 993-996. doi: 10.1016/S0092-8674(00)00201-4
Identification of mammalian-like purple acid phosphatases in a wide range of plants
Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4
Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.
Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000). Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 (4), 427-438. doi: 10.1089/107999000312379
Macrophage activation by immunostimulatory DNA
Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000). Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247, 41-58. doi: 10.1007/978-3-642-59672-8_3
Origins and functions of phagocytes in the embryo
Lichanska, A. M. and Hume, D. A. (2000). Origins and functions of phagocytes in the embryo. Experimental Hematology, 28 (6), 601-611. doi: 10.1016/S0301-472X(00)00157-0
Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1
Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000). Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 (8), 4165-4173. doi: 10.4049/jimmunol.165.8.4165
Hume, David A. (2000). Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood, 96 (7), 2323-2328. doi: 10.1182/blood.v96.7.2323.h8002323_2323_2328
Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes
Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X
Fowles, L. F., Stacey, K. J., Marks, D., Hamilton, J. A. and Hume, D. A. (2000). Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochemical Journal, 347 (1), 313-320. doi: 10.1042/0264-6021:3470313
Luchin, A., Purdom, G., Murphy, K. M., Clark, M., Angel, N., Cassady, A. I., Hume, D. A. and Ostrowski, M. (2000). The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts. Journal of Bone and Mineral Research, 15 (3), 451-460. doi: 10.1359/jbmr.2000.15.3.451
Angel, N., Cahill, M. M., King, A., Ostrowski, M., Cassady, A. I. and Hume, D. A. (2000). Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover. Journal of Bone and Mineral Research, 15 (1), 103-110. doi: 10.1359/jbmr.2000.15.1.103
S100A8: Emerging functions and regulation
Passey, Robert J., Xu, Ken, Hume, David A. and Geczy, Carolyn L. (1999). S100A8: Emerging functions and regulation. Journal of Leukocyte Biology, 66 (4), 549-556. doi: 10.1002/jlb.66.4.549
Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999). A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 (4), 2209-2216.
Lichanska, Agnieszka M., Browne, Catherine M., Henkel, Gregory W., Murphy, Kathleen M., Ostrowski, Michael C., McKercher, Scott R., Maki, Richard A. and Hume, David A. (1999). Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1. Blood, 94 (1), 127-138.
Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999). Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 (4), 279-291. doi: 10.3109/08977199909069146
Young scientists in biomedical research
Hume, DA (1999). Young scientists in biomedical research. Science, 284 (5411), 49-49. doi: 10.1126/science.284.5411.49c
Rehli, Michael, Den Elzen, Nicole, Cassady, A. Ian, Ostrowski, Michael C. and Hume, David A. (1999). Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics, 56 (1), 111-120. doi: 10.1006/geno.1998.5588
Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999). Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 (12), 6541-6550.
CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages
Kakuda, D. K., Sweet, M. J., MacLeod, C. L., Hume, D. A. and Markovich, D. (1999). CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochemical Journal, 340 (2), 549-553. doi: 10.1042/0264-6021:3400549
Crystal structure of mammalian purple acid phosphatase
Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E., De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase. Structure With Folding & Design, 7 (7), 757-767. doi: 10.1016/S0969-2126(99)80100-2
Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase
Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J., Hamilton, S. E. and Martin, J. L. (1999). Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase. Acta Crystallographica Section D: Biological Crystallography, 55 (8), 1462-1464. doi: 10.1107/S0907444999006241
Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide
Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999). Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 (3), 528-534. doi: 10.1002/jlb.66.3.528
Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999). Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 (1), 172-183. doi: 10.1002/jlb.66.1.172
Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. and Hume, D. A. (1999). TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Journal of Immunology, 162 (3), 1559-1565.
The actions of bacterial DNA on murine macrophages
Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999). The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 (4), 542-548. doi: 10.1002/jlb.66.4.542
Fowles, Lindsay F., Martin, Michele L., Nelsen, Lori, Stacey, Katryn J., Redd, Douglas, Clark, Ying Mei, Nagamine, Yoshikune, McMahon, Martin, Hume, David A. and Ostrowski, Michael C. (1998). Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling. Molecular and Cellular Biology, 18 (9), 5148-5156. doi: 10.1128/MCB.18.9.5148
Ross, Ian L., Yue, Xie, Ostrowski, Michael C. and Hume, David A. (1998). Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific basal transcription initiation. Journal of Biological Chemistry, 273 (12), 6662-6669. doi: 10.1074/jbc.273.12.6662
IFN-γ primes macrophage responses to bacterial DNA
Sweet, M. J., Stacey, K. J., Kakuda, D. K., Markovich, D. and Hume, D. A. (1998). IFN-γ primes macrophage responses to bacterial DNA. Journal of Interferon and Cytokine Research, 18 (4), 263-271. doi: 10.1089/jir.1998.18.263
Sweet, M. J., Stacey, K. J., Ross, I. L., Ostrowski, M. C. and Hume, D. A. (1998). Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophage. Journal of Inflammation, 48 (2), 67-83.
Osborne, JM, den Elzen, N, Lichanska, AM, Costelloe, EO, Yamada, T, Cassady, AI and Hume, DA (1998). Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS. Journal of Leukocyte Biology, 64 (5), 692-701. doi: 10.1002/jlb.64.5.692
Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2
D'Orazio, Daniel, Besser, Daniel, Marksitzer, René, Kunz, Christina, Hume, David A., Kiefer, Birgitta and Nagamine, Yoshikuni (1997). Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene, 201 (1-2), 179-187. doi: 10.1016/S0378-1119(97)00445-9
Recombinant human and mouse purple acid phosphatases: expression and characterization
Marshall, Karen, Nash, Kevin, Haussman, George, Cassady, Ian, Hume, David, De Jersey, John and Hamilton, Susan (1997). Recombinant human and mouse purple acid phosphatases: expression and characterization. Archives of Biochemistry and Biophysics, 345 (2), 230-236. doi: 10.1006/abbi.1997.0250
Effects of CSF-1 on cholesterol accumulation and efflux by macrophages
Jessup, W, Squires, B, Kritharides, L, Hume, DA and Dean, RT (1997). Effects of CSF-1 on cholesterol accumulation and efflux by macrophages. Arteriosclerosis Thrombosis and Vascular Biology, 17 (1), 18-25. doi: 10.1161/01.ATV.17.1.18
Regulation of CSF-1 receptor expression
Hume, D. A., Yue, X., Ross, I. L., Favot, P., Lichanska, A. and Ostrowski, M. C. (1997). Regulation of CSF-1 receptor expression. Molecular Reproduction and Development, 46 (1), 46-53. doi: 10.1002/(SICI)1098-2795(199701)46:1<46::AID-MRD8>3.0.CO;2-R
Marketing for leisure and tourism - Michael Morgan
Hume, David A. (1996). Marketing for leisure and tourism - Michael Morgan. Tourism Management, 17 (8), 621-621. doi: 10.1016/S0261-5177(97)84227-6
Yue, X., Ross, I. L., Browne, C. M., Lichanska, A., Favot, P., Ostrowski, M. C. and Hume, D. A. (1996). Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1). Immunobiology, 195 (4-5), 461-476. doi: 10.1016/S0171-2985(96)80016-7
Endotoxin signal transduction in macrophages
Sweet, M. J. and Hume, D. A. (1996). Endotoxin signal transduction in macrophages. Journal of Leukocyte Biology, 60 (1), 8-26. doi: 10.1002/jlb.60.1.8
Delaney, Stephen J., Alton, Eric W.F.W., Smith, Stephen N., Lunn, Dominic P., Farley, Ray, Lovelock, Paul K., Thomson, Scott A., Hume, David A., Lamb, David, Porteous, David J., Dorin, Julia R. and Wainwright, Brandon J. (1996). Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO Journal, 15 (5), 955-963. doi: 10.1002/j.1460-2075.1996.tb00432.x
Yang, Beom-Seok, Hauser, Craig A., Henkel, Gregory, Colman, Michael S., Van Beveren, Charles, Stacey, Katryn J., Hume, David A., Maki, Richard A. and Ostrowski, Michael C. (1996). Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Molecular and Cellular Biology, 16 (2), 538-547. doi: 10.1128/MCB.16.2.538
Sweet, M. J. and Hume, D. A. (1996). Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264. Journal of Leukocyte Biology, 59 (2), 280-286. doi: 10.1002/jlb.59.2.280
Symons, AL, Mackay, CA, Leong, K, Hume, DA, Waters, MJ and Marks, SC (1996). Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1. Growth Factors, 13 (1-2), 1-+. doi: 10.3109/08977199609034562
Macrophages ingest and are activated by bacterial DNA
Stacey, K. J., Sweet, M. J. and Hume, D. A. (1996). Macrophages ingest and are activated by bacterial DNA. Journal of Immunology, 157 (5), 2116-2122.
Chen, C.M., Clarkson, R.W., Xie, Y., Hume, D.A. and Waters, M.J. (1995). Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter. Endocrinology, 136 (10), 4505-4516. doi: 10.1210/en.136.10.4505
Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines
Favot, P, Yue, X and Hume, DA (1995). Regulation of the C-Fms Promoter in Murine Tumor-Cell Lines. Oncogene, 11 (7), 1371-1381.
Stacey, Katryn J., Fowles, Lindsay F., Colman, Michael S., Ostrowski, Michael C. and Hume, David A. (1995). Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Molecular and Cellular Biology, 15 (6), 3430-3441. doi: 10.1128/MCB.15.6.3430
Hume, D. A., Monkley, S. J. and Wainwright, B. J. (1995). Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling. British Journal of Haematology, 90 (4), 939-942. doi: 10.1111/j.1365-2141.1995.tb05220.x
Hume D.A. and Favot P. (1995). Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?. Journal of Interferon and Cytokine Research, 15 (4), 279-284. doi: 10.1089/jir.1995.15.279
Sweet, M. J. and Hume, D. A. (1995). RAW264 macrophages stably transfected with an HIV-1-LTR reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated with lipopolysaccharide, TNF-α or taxol. Journal of Inflammation, 45 (2), 126-135.
RNA synthesis inhibition stabilises urokinase mRNA in macrophages
Stacey, Katryn J., Nagamine, Yoshikuni and Hume, David A. (1994). RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letters, 356 (2-3), 311-313. doi: 10.1016/0014-5793(94)01294-6
Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A. and Ostrowski, M. C. (1994). Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. Journal of Experimental Medicine, 180 (6), 2309-2319. doi: 10.1084/jem.180.6.2309
Transcription of individual genes in eukaryotic cells occurs randomly and infrequently
Ross, Ian L., Browne, Catherine M. and Hume, David A. (1994). Transcription of individual genes in eukaryotic cells occurs randomly and infrequently. Immunology and Cell Bbiology, 72 (2), 177-185. doi: 10.1038/icb.1994.26
Ross, I. L., Dunn, T. L., Yue, X., Roy, S., Barnett, C. J. and Hume, DA (1994). Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene, 9 (1), 121-132.
The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line
Murphy, K. M., Sweet, M. J. and Hume, D. A. (1994). The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line. Journal of Leukocyte Biology, 56 (3), 294-303. doi: 10.1002/jlb.56.3.294
Murphy, Kathleen M., Sweet, Matthew J., Ross, Ian L. and Hume, David A. (1993). Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages. Journal of Virology, 67 (12), 6956-6964. doi: 10.1128/jvi.67.12.6956-6964.1993
Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase
Cassady, A. Ian, King, Andrew G., Cross, Nicholas C. P. and Hume, David A. (1993). Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. Gene, 130 (2), 201-207. doi: 10.1016/0378-1119(93)90420-8
Yue, Xie, Favot, Paula, Dunn, Timothy L., Cassady, A. Ian and Hume, David A. (1993). Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Molecular and Cellular Biology, 13 (6), 3191-3201. doi: 10.1128/MCB.13.6.3191
Electroporation and DNA-dependent cell-death in murine macrophages
Stacey, Katryn J., Ross, Ian L. and Hume, David A. (1993). Electroporation and DNA-dependent cell-death in murine macrophages. Immunology and Cell Biology, 71 (2), 75-85. doi: 10.1038/icb.1993.8
Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria
Pavli, P, Hume, DA, Vandepol, E and Doe, WF (1993). Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria. Immunology, 78 (1), 132-141.
Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993). The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 (3), 392-401. doi: 10.1111/j.1365-2141.1993.tb03092.x
Le, Fei, Wilce, Peter A., Hume, David A. and Shanley, Brian C. (1992). Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain. Journal of Neurochemistry, 59 (4), 1309-1315. doi: 10.1111/j.1471-4159.1992.tb08442.x
Doyle, Anthony G., Halliday, William J., Barnett, Christopher J., Dunn, Timothy L. and Hume, David A. (1992). Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice. Infection and Immunity, 60 (4), 1465-1472. doi: 10.1128/IAI.60.4.1465-1472.1992
Warren, Hilary S., Hodder, Michelle J., Allan, William, Hume, David A. and Simeonovic, Charmaine J. (1992). Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts. Transplantation, 53 (4), 834-840. doi: 10.1097/00007890-199204000-00025
Hume, D., McGarry, M. P. and Stewart, C. (1992). Letter to the editor. Journal of Leukocyte Biology, 51 (5), 517-518. doi: 10.1002/jlb.51.5.517
Lüthe, Rudolf and Hume, David (1992). Rezensionen. Deutsche Zeitschrift fur Philosophie, 40 (12), 1471-1488. doi: 10.1524/dzph.1992.40.12.1471
Todd, B., Pope, J. H., Ross, I. L. and Hume, D. A. (1992). Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication. Journal of Virological Diseases, 1, 24-33.
Hume, D. A. and Denkins, Y. (1992). The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine and Cytokine Research, 11 (2), 95-98.
Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991). Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 (24), 6839-6847. doi: 10.1093/nar/19.24.6839
Breen, FN, Hume, DA and Weidemann, MJ (1991). Interactions Among Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Ifn-Gamma Lead to Enhanced Proliferation of Murine Macrophage Progenitor Cells. Journal of Immunology, 147 (5), 1542-1547.
Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain
Le, F., Wilce, P. A., Cassady, I., Hume, D. A. and Shanley, B. C. (1991). Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. Alcohol and Alcoholism. Supplement, 1, 211-214.
Abd, A.-H.A., Savage, N.W., Halliday, W.J. and Hume, D.A. (1991). The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: Actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents. Lymphokine and Cytokine Research, 10 (1-2), 43-50.
Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain
Le, Fei, Wilce, Peter, Cassady, Ian, Hume, David and Shanley, Brain (1990). Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. Neuroscience Letters, 120 (2), 271-274. doi: 10.1016/0304-3940(90)90057-G
Pavli, P, Woodhams, CE, Doe, WF and Hume, DA (1990). Isolation and Characterization of Antigen-Presenting Dendritic Cells From the Mouse Intestinal Lamina Propria. Immunology, 70 (1), 40-47.
Breen, Frances N., Hume, David A. and Weidemann, Maurice J. (1990). The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture. British Journal of Haematology, 74 (2), 138-145. doi: 10.1111/j.1365-2141.1990.tb02556.x
Abd, Aha, Hume, DA, Halliday, WJ and Davis, Ghg (1990). Immunopathological Investigations During the Course of Arthritis Induced in Rats by Streptococcus-Agalactiae. Medical Microbiology and Immunology, 179 (1), 13-23. doi: 10.1007/BF00190146
Macrophage colony-stimulating factor
Hume D. (1990). Macrophage colony-stimulating factor. Today's Life Science, 2 (6)
Hume, DA and Nayar, R (1989). Encapsulation Is Not Involved in the Activities of Recombinant Gamma-Interferon Associated with Multilamellar Phospholipid Liposomes On Murine Bone Marrow-Derived Macrophages. Lymphokine Research, 8 (4), 415-425.
Hume, D. A., Donahue, R. E. and Fidler, I. J. (1989). The therapeutic effect of human recombinant macrophage colony stimulating factor (Csf-1) in experimental murine metastatic melanoma. Lymphokine Research, 8 (1), 69-77.
Hume D.A. and Denkins Y.M. (1989). Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction. Immunology and Cell Biology, 67 (4), 243-249. doi: 10.1038/icb.1989.37
Hume, DA, Pavli, P, Donahue, RE and Fidler, IJ (1988). The Effect of Human Recombinant Macrophage Colony-Stimulating Factor (Csf-1) On the Murine Mononuclear Phagocyte System Invivo. Journal of Immunology, 141 (10), 3405-3409.
Schackert, Gabriele, Simmons, Rex D., Buzbee, Thomas M., Hume, David A. and Fidler, Isaiah J. (1988). Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier. Journal of the National Cancer Institute, 80 (13), 1027-1034. doi: 10.1093/jnci/80.13.1027
Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice
Russell, Pamela J., Philips, Jeanette, Allan, William and Hume, David A. (1988). Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice. Journal of Leukocyte Biology, 43 (4), 335-342. doi: 10.1002/jlb.43.4.335
Direct demonstration of production of transforming growth factor activity by embryonic chick tissue
McLachlan, J. C., Macintyre, J., Hume, D. D. and Smith, J. (1988). Direct demonstration of production of transforming growth factor activity by embryonic chick tissue. Experientia, 44 (4), 351-352. doi: 10.1007/BF01961280
Simeonovic, CJ, Hodder, MJ and Hume, DA (1988). Role of Ia-Positive Leukocytes and F4/80-Positive Macrophages in the Immunogenicity of Fetal Mouse Proislets and Fetal Pancreas. Transplantation Proceedings, 20 (1), 68-71.
A microwell assay for anchorage independent cell growth
Macintyre, John, Hume, David D., Smith, Janet and McLachlan, John C. (1988). A microwell assay for anchorage independent cell growth. Tissue and Cell, 20 (3), 331-338. doi: 10.1016/0040-8166(88)90068-7
Hume, D. A., Allan, W., Hogan, P. G. and Doe, W. F. (1987). Immunohistochemical characterization of macrophages in human-liver and gastrointestinal tract - expression of Cd4, Hla-Dr, Okm1, and the mature macrophage marker 25F9 in normal and diseased tissue. Journal of Leukocyte Biology, 42 (5), 474-484. doi: 10.1002/jlb.42.5.474
Hume, D. A. (1987). Growth-regulation in murine bone marrow-derived macrophages - effects of contaminating endotoxin in commercial Gm-Csf and interleukin-4. Lymphokine Research, 6 (4), 357-359.
Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin
Müllbacher, A., Hume, D., Braithwaite, A. W., Waring, P. and Eichner, R. D. (1987). Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin. Proceedings of the National Academy of Sciences of the United States of America, 84 (11), 3822-3825. doi: 10.1073/pnas.84.11.3822
Regulation of proliferation of bone marrow-derived macrophages
Hume, D. A, Allan, W., Fabrus, B., Weidemann, M. J., Hapel, A. J. and Bartelmez, S. (1987). Regulation of proliferation of bone marrow-derived macrophages. Lymphokine Research, 6 (2), 127-139.
Warren, HS, Simeonovic, CJ, Allan, W and Hume, DA (1987). Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells. Transplantation Proceedings, 19 (1), 213-213.
Dixon, J. E., Allan, J. E., Doherty, P. C. and Hume, D. A. (1986). Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus. Journal of Leukocyte Biology, 40 (5), 617-628.
Localization and function of tissue macrophages
Gordon, Siamon, Crocker, Paul R., Morris, Lynn, Lee, Szu Hee, Perry, V. Hugh and Hume, David A. (1986). Localization and function of tissue macrophages. Ciba Foundation Symposia, 118, 54-67. doi: 10.1002/9780470720998.ch5
Hume, D. A. (1985). Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens. Immunobiology, 170 (5), 381-389. doi: 10.1016/S0171-2985(85)80062-0
Hume, D. A. (1985). The biology of macrophages. Science progress, 69 (276), 485-494.
Preparation and characterization of human-bone marrow-derived macrophages
Hume, D. A., Allan, W., Golder, J., Stephens, R. W., Doe, W. F. and Warren, H. S. (1985). Preparation and characterization of human-bone marrow-derived macrophages. Journal of Leukocyte Biology, 38 (4), 541-552. doi: 10.1002/jlb.38.4.541
Hume, David A., Summers, Kim M., Cohen, Donna R. and Allan, William (1985). Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines. FEBS Letters, 180 (2), 271-274. doi: 10.1016/0014-5793(85)81084-X
Hapel, A. J., Osborne, J. M., Fung, M. C., Young, I. G., Allan, W. and Hume, D. A. (1985). Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors. Journal of Immunology, 134 (4), 2492-2497.
Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines
Summers, KM and Hume, DA (1985). Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines. Lymphokine Research, 4 (3), 229-235.
Perry, V. H., Hume, D. A. and Gordon, S. (1985). Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience, 15 (2), 313-326. doi: 10.1016/0306-4522(85)90215-5
Minactivin Expression in Human Monocyte and Macrophage Populations
Stephens, RW, Golder, JP, Fayle, Drh, Hume, DA, Hapel, AJ, Allan, W, Fordham, CJ and Doe, WF (1985). Minactivin Expression in Human Monocyte and Macrophage Populations. Blood, 66 (2), 333-337.
Russell, P. J., Cahill, J., Cameron, F. and Hume, D. (1985). Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. Journal of Leukocyte Biology, 38 (2), 241-254. doi: 10.1002/jlb.38.2.241
Hume, David A., Perry, V. Hugh and Gordon, Siamon (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anatomical Record, 210 (3), 503-512. doi: 10.1002/ar.1092100311
Hume, David A. and Gordon, Siamon (1984). The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E. Experimental Cell Research, 150 (2), 347-355. doi: 10.1016/0014-4827(84)90578-0
Hapel, A. J., Warren, H. S. and Hume, D. A. (1984). Different colon-stimulating factors are detected by the interleukin-3 dependent cell-lines Fdc-Pl and 32D Cl-23. Blood, 64 (4), 786-790.
Hume, D. A., Loutit, J. F. and Gordon, S. (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of bone and associated connective tissue. Journal of Cell Science, VOL. 66, 189-194.
Hume, D. A., Halpin, D., Charlton, H. and Gordon, S. (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of endocrine organs. Proceedings of the National Academy of Sciences of the United States of America, 81 (13 I), 4174-4177. doi: 10.1073/pnas.81.13.4174
Hume, David A. and Gordon, Siamon (1983). Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: the roles of CSF‐1, serum, Ca2+, and adherence. Journal of Cellular Physiology, 117 (2), 189-194. doi: 10.1002/jcp.1041170209
Hume, David A., Robinson, Anne P., Macpherson, Gordon G. and Gordon, Siamon (1983). The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. Journal of Experimental Medicine, 158 (5), 1522-1536. doi: 10.1084/jem.158.5.1522
Hume, David A., Gordon, Siamon, Thornalley, Paul J. and Bannister, Joe V. (1983). The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages: an electron paramagnetic resonance study of the response to phorbol myristate acetate. Biochimica Et Biophysica Acta, 763 (3), 245-250. doi: 10.1016/0167-4889(83)90131-3
Hume, D. A., Perry, V. H. and Gordon, S. (1983). Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. Journal of Cell Biology, 97 (1), 253-257. doi: 10.1083/jcb.97.1.253
Hume, David A. and Gordon, Siamon (1983). Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. Journal of Experimental Medicine, 157 (5), 1704-1709. doi: 10.1084/jem.157.5.1704
Summers, K. M., Harrison, G. A., Hume, D. A. and Palmer, C. D. (1983). Urinary hormone levels: a population study of associations between steroid and catecholamine excretion rates. Annals of Human Biology, 10 (2), 99-110. doi: 10.1080/03014468300006241
Regulation of Bone-Marrow Macrophage Proliferation
Hume, DA and Gordon, S (1982). Regulation of Bone-Marrow Macrophage Proliferation. Advances in Experimental Medicine and Biology, 155, 261-266.
Hume, D. A., Wrogemann, K., Ferber, E., Kolbuchbraddon, M. E., Taylor, R. M., Fischer, H. and Weidemann, M. J. (1981). Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis. Biochemical Journal, 198 (3), 661-667. doi: 10.1042/bj1980661
Hume, David A., Thornton, Mary R., Weidemann, Maurice J. and Speth, Volker (1979). Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli. Journal of Cellular Physiology, 101 (3), 523-528. doi: 10.1002/jcp.1041010318
Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport
Hume, DA, Weidemann, MJ and Ferber, E (1979). Preferential Inhibition by Quercetin of Mitogen-Stimulated Thymocyte Glucose-Transport. Journal of the National Cancer Institute, 62 (5), 1243-1246.
Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport
Hume, D. A., Weidemann, M. J. and Ferber, E. (1979). Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport. Journal of the National Cancer Institute, 62 (5), 1243-1249. doi: 10.1093/jnci/62.5.1243
Role and Regulation of Glucose-Metabolism in Proliferating Cells
Hume, DA and Weidemann, MJ (1979). Role and Regulation of Glucose-Metabolism in Proliferating Cells. Journal of the National Cancer Institute, 62 (1), 3-3.
Role and regulation of glucose metabolism in proliferating cells
Hume, D. A. and Weidemann, M. J. (1979). Role and regulation of glucose metabolism in proliferating cells. Journal of the National Cancer Institute, 62 (1), 3-8. doi: 10.1093/jnci/62.1.3
Aerobic glycolysis and lymphocyte transformation
Hume, David A., Radik, Judith L., Ferber, Ernst and Weidemann, Maurice J. (1978). Aerobic glycolysis and lymphocyte transformation. Biochemical Journal, 174 (3), 703-709. doi: 10.1042/bj1740703
On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli
Hume, David A. and Weidemann, Maurice J. (1978). On the stimulation of rat thymocyte 3‐0‐methyl‐glucose transport by mitogenic stimuli. Journal of Cellular Physiology, 96 (3), 303-308. doi: 10.1002/jcp.1040960305
Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport
Hume, D. A., Hansen, K., Weidemann, M. J. and Ferber, E. (1978). Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport. Nature, 272 (5651), 359-359. doi: 10.1038/272359a0
Effect of Nh4 and Ca2+ on gluconeogenesis from lactate by isolated rat hepatocytes
Hume, D. A. and Weidemann, M. J. (1978). Effect of Nh4 and Ca2+ on gluconeogenesis from lactate by isolated rat hepatocytes. Hormone and Metabolic Research, 10 (5), 449-450. doi: 10.1055/s-0028-1095840
The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens
Hume, D. A., Vijayakumar, E. K., Schweinberger, F., Russell, L. M. and Weidemann, M. J. (1978). The role of calcium ions in the regulation of rat thymocyte pyruvate oxidation by mitogens. Biochemical Journal, 174 (3), 711-716. doi: 10.1042/bj1740711
Yasmeen, Dilruba, Laird, Alan J., Hume, David A. and Weidemann, Maurice J. (1977). Activation of 3-O-methyl-glucose transport in rat thymus lymphocytes by concanavalin A: temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide. Biochimica Et Biophysica Acta, 500 (1), 89-102. doi: 10.1016/0304-4165(77)90049-6
Hormonal regulation of gluconeogenesis in isolated rat hepatocytes: An undergraduate experiment
hume, David A. and weidemann, Maurice J. (1976). Hormonal regulation of gluconeogenesis in isolated rat hepatocytes: An undergraduate experiment. Biochemical Education, 4 (1), 13-14. doi: 10.1016/0307-4412(76)90013-3
Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease
Whiley, P., Summers, K., Pavli, P., Hume, D. and O'Brien, C. (2023). Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease. HOBOKEN: WILEY.
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy, Millard, Susan, Batoon, Lena, Sandrock, Cheyenne, Levesque, Jean-Pierre, Hume, David, Raggatt, Liza and Pettit, Allison (2020). 3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, New York, NY USA, 20-23 August 2020. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.exphem.2020.09.105
Irvine, Katharine, Genz, Berit, Clouston, Andrew D. and Hume, David (2018). Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco, CA USA, 9-13 November 2018. Hoboken, NJ USA: Wiley.
Pettit, Allison, Kaur, Simranpreet, Raggatt, Liza, Millard, Susan, Wu, Andy, Batoon, Lena, Jacobsen, Rebecca, Winkler, Ingrid, MacDonald, Kelli, Perkins, Andrew, Hume, David and Levesque, Jean-Pierre (2018). Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation. 47th Annual Scientific Meeting of the International Society for Experimental Hematology, Los Angeles, CA, United States, 23-26 August 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2018.06.117
Evolution of cell death responses to cytosolic DNA
Vitak, N., Johnson, K. N., Hume, D. A., Sester, D. P. and Stacey, K. J. (2016). Evolution of cell death responses to cytosolic DNA. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049
Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages
Kaur, Simranpreet, Raggatt, Liza J., Jacobsen, Rebecca, Millard, Susan, Barbier, Valerie, Nowlan, Bianca, Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean P. and Pettit, Allison R. (2015). Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, Japan, 17-19 September 2015. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2015.06.157
Cross species reactivity of Interleukin 34 (IL-34)
Gow, D. J., Garceau, V., Sester, D. and Hume, D. A. (2012). Cross species reactivity of Interleukin 34 (IL-34). European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Gow, D. J., Garceau, V., Moffat, L., Kapetanovic, R., Sester, D. and Hume, D. A. (2012). The production of porcine anti-CSF-1R antibodies: reagents to evaluate the effects of CSF-1 on postnatal growth. European Congress of Immunology, Glasgow Scotland, 5-8 September 2012. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Gene targeting of the rat Csf1r locus using homologous recombination in ES cells
Upton, Kyle R., Pridans, Clare, Meek, Stephen, Sutherland, Linda, Whitelaw, Bruce, Burdon, Tom and Hume, David (2011). Gene targeting of the rat Csf1r locus using homologous recombination in ES cells. 10th Transgenic Technology Meeting (TT2011), Florida, United States, 24-26 October 2011. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s11248-011-9540-8
Forrest, A. R. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., de Hoon, M. J. L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A. and Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. ELSEVIER SCI LTD. doi: 10.1016/j.diff.2010.09.048
Ebert, Stefanie, Weigelt, Karin, Drobnik, Wolfgang, Mauerer, Richard, Hume, David A., Weber, Bernhard H. F. and Langmann, Thomas (2009). Docosahexaenoic acid (22:6n-3) protects from early retinal degeneration and attenuates microglial activation. 50th International Conference on Bioscience of Lipids, Regenburg Germany, Sep 01-05, 2009. ELSEVIER IRELAND LTD. doi: 10.1016/j.chemphyslip.2009.06.022
Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, 11-15 September, 2009. United States: American Society for Bone and Mineral Research.
Alexander, K. A., Raggatt, L. J., Chang, M. K., Maylin, E. R., Muller, R., Kohler, T., Wu, A. C. K., Hume, D. A. and Pettit, A. R. (2009). Osteomacs are critical for optimal intramembranous bone formation in a tibial defect model of bone healing. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, NSW, Australia, 21-25 March 2009. United States: Elsevier. doi: 10.1016/j.bone.2009.01.076
Raggatt, L. J., Chang, M. K., Alexander, K. A., Maylin, E. R., Walsh, N. C., Gravallese, E. M., Hume, D. A. and Pettit, A. R. (2009). Osteomacs: osteoclast precursors during inflammatory bone disease but regulators of physiologic bone remodelling. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, Australia, 21-25 March, 2009. New York: Elsevier Science. doi: 10.1016/j.bone.2009.01.300
The identification of novel CSF-1 target genes in human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, Oct 12-16, 2008. LONDON: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2008.07.078
Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth
Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, Sharon D. (2008). Colony Stimulating Factor (Csf)-1 in Postnatal Nephrogenesis and Organ Growth. HOBOKEN: WILEY-BLACKWELL.
Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation
Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, NY, U.S.A.: Springer New York. doi: 10.1007/s00223-008-9118-5
Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization
Alexander, K. A., Chang, M. K., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoli, V. M. and Schroder, K. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization. 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, USA: Springer. doi: 10.1007/s00223-008-9118-5
Mackay, Charles, Cyster, Jason, Goodnow, Christopher C., Lam, Kong-Peng, Vinuesa, Carola, Malissen, Bernard, Gros, Philippe, Turner, Stephen, Kaufman, Jim and Hume, David (2007). Discussion.
Casanova, Jean-Laurent, Britton, Warwick J., Gros, Philippe, Morahan, Grant, Hume, David, Cyster, Jason, Goodnow, Christopher C., Turner, Stephen and Cook, Matthew (2007). Discussion.
Morahan, Grant, Maizels, Rick M., Malissen, Bernard, Cyster, Jason, Turner, Stephen, Vinuesa, Carola, Britton, Warwick J., Hume, David, Lam, Kong-Peng and Cook, Matthew (2007). Discussion.
Goodnow, Christopher C., Casanova, Jean-Laurent, Wakeland, Edward K., Morahan, Grant, Young, Douglas, Britton, Warwick J., Hume, David, Gros, Philippe, Kaufman, Jim, Maizels, Rick M. and Karupiah, Gunasegaran (2007). Discussion.
Casanova, Jean-Laurent, Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Gros, Philippe, Hume, David, Lam, Kong-Peng, Malissen, Bernard, Vinuesa, Carola and Wakeland, Edward K. (2007). Discussion.
Alexander, Warren S., Gros, Philippe, Hume, David, Schönbach, Christian and Vinuesa, Carola (2007). Discussion.
Wakeland, Edward K., Morahan, Grant, Hume, David, Foote, Simon, Goodnow, Christopher C., Fortin, Anny and Gros, Philippe (2007). Discussion.
Casanova, Jean-Laurent, Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Hume, David, Lam, Kong-Peng, Mackay, Charles, Maizels, Rick M. and Malissen, Bernard (2007). Discussion.
Britton, Warwick J., Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Karupiah, Gunasegaran, Mackay, Charles, Morahan, Grant, Turner, Stephen and Young, Douglas (2007). Discussion.
Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Karupiah, Gunasegaran, Maizels, Rick M., Scalzo, Anthony, Turner, Stephen and Wakeland, Edward K. (2007). Discussion.
Cyster, Jason, Goodnow, Christopher C., Hume, David, Karupiah, Gunasegaran, Lam, Kong-Peng, Mackay, Charles, Morahan, Grant, Scalzo, Anthony, Stacker, Steven, Vinuesa, Carola and Wakeland, Edward K. (2007). Discussion.
Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice
Jones, C. V., Little, M. H., Hume, D. A. and Ricardo, S. D. (2007). Colony Stimulating Factor (Csf)-1 Promotes Nephrogenesis and Postnatal Growth in Newborn Mice. HOBOKEN: WILEY-BLACKWELL.
Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model
Ricardo, S. D., Alikhan, M. A., Campanale, N. V., Hume, D. A. and Little, M. H. (2007). Colony Stimulating Factor Reverses Established Renal Injury in An Acute Ischemic Mouse Model. HOBOKEN: WILEY-BLACKWELL.
Belz, Gabrielle, Britton, Warwick J., Casanova, Jean-Laurent, Foote, Simon, Goodnow, Christopher C., Gros, Philippe, Hume, David, Maizels, Rick M. and Turner, Stephen (2007). Discussion. Symposium on Cortical development: genes and genetic abnormalities, London, United Kingdom, 6–8 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Alexander, Warren S., Belz, Gabrielle, Britton, Warwick J., Cook, Matthew, Cyster, Jason, Goodnow, Christopher C., Hume, David, Kaufman, Jim, Mackay, Charles, Stacker, Steven and Turner, Stephen (2007). Discussion. Symposium on Cortical development: genes and genetic abnormalities, London, United Kingdom, 6–8 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Goodnow C.C., Maizels R.M., Hume D., Kaufman J., Schonbach C., Gros P. and Britton W.J. (2007). General discussion I.
Osteal Macrophages: Novel regulators of Bone Formation
Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, 16th -19th September, 2007. Washington, D.C., United States: American Society for Bone and Mineral Research.
Osteal macrophages: Novel regulators of bone formation
Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, United States, 16-19 September 2007.
The Jun N-terminal kinases are important for the survival and development of macrophages
Sester, D. P., Hines, S. R., Ravasi, T., Cronau, S. L., Sasmono, T. and Hume, D. A. (2007). The Jun N-terminal kinases are important for the survival and development of macrophages. Annual Congress of the British Society of Immunology, Glasgow, Scotland, 20-23 February 2007. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
The endosteal bone niche contains macrophages that regulate osteoblast function
Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, 24-29 June 2007. New York: Elsevier Science. doi: 10.1016/j.bone.2007.04.166
Transcriptional regulatory networks in macrophages
Hume D.A., Wells C.A. and Ravasi T. (2007). Transcriptional regulatory networks in macrophages.
Structure and function of mammalian fibrillin genes
Summers, K and Hume, D A (2006). Structure and function of mammalian fibrillin genes. 11th International Congress of Human Genetics, Brisbane, 6-10 Aug, 2006.
T cells are the source of GM-CSF required for collagen-induced arthritis induction.
Cook, Andrew D., Tumer, Amanda L., Braine, Emma L., Hume, David A. and Hamilton, John A. (2006). T cells are the source of GM-CSF required for collagen-induced arthritis induction.. 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Washington Dc, Nov 10-15, 2006. WILEY-LISS.
The use of transgenes to study macrophage differentiation and function
Hume, D. A. (2006). The use of transgenes to study macrophage differentiation and function. 7th Transgenic Technology Meeting (TT2007), St Lucia, Brisbane, Australia, 12-14 February 2007. Amsterdam, The Netherlands: Springer Netherlands. doi: 10.1007/s11248-006-9047-x
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. BASEL: BIRKHAUSER VERLAG AG.
PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages
Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. BASEL: BIRKHAUSER VERLAG AG.
Beta-arrestin expression and function in macrophages
Lattin, Jane E., Blomberg, Lovisa M., Daly, Norelle L., Craik, David J., Robinson, Jodie A., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2005). Beta-arrestin expression and function in macrophages. 7th World Congress on Inflammation: Inflammation 2005: Inflammation, the Key to much pathology, Melbourne, Australia, 20 - 24 August 2005. Basel, Switzerland: Birkhaeuser.
Blockade of CSF-1 action enhances CpG DNA responses in vivo
Trieu, Angela, Cronau, Steve, Roberts, Tara, Lottin, Jane, Vlahos, Ross, Stacey, Katryn J., Hume, David A. and Sweet, Matthew J. (2005). Blockade of CSF-1 action enhances CpG DNA responses in vivo. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Investigation into the role of protein tyrosine phosphatase DEP-1 in macrophage function
Dave, R., Wilson, T., Cook, A., Vlahos, R., Hume, D. and Kellie, S. (2005). Investigation into the role of protein tyrosine phosphatase DEP-1 in macrophage function. 38th Annual Meeting of the Society-for-Leukocyte-Biology, Oxford, United Kingdom, 21-24 September 2005. BETHESDA: FEDERATION AMER SOC EXP BIOL.
Novel macrophage-restricted gene involved in inflammation
Ripoll, Vera M., Ravasi, Timothy and Hume, David A. (2005). Novel macrophage-restricted gene involved in inflammation. BASEL: BIRKHAUSER VERLAG AG.
Purified splenic B-cells do not respond to E. coli DNA
Roberts, Tara L., Dann, Jasmyn A., Sweet, Matthew J., Hume, David A., Lenert, Petar and Stacey, Katryn J. (2005). Purified splenic B-cells do not respond to E. coli DNA. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Regulation and function of toll-like receptor 9 in macrophages
Sweet, Matthew J., Schroder, Kate, Sester, David P., Trieu, Angela, Rehli, Michael, Risvanathan, Kumar, Stacey, Katryn J. and Hume, David A. (2005). Regulation and function of toll-like receptor 9 in macrophages. 7th World Congress on Inflammation, Melbourne, VIC Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS
Hume, David A., Ravasi, Timothy and Wells, Christine (2004). Genetic and epigenetic modification of the transcriptional response of mouse macrophages to LPS. 1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), Budapest, Hungary, 3-7 October 2004. Malden, MA, United States: Wiley-Blackwell. doi: 10.1111/j.1399-0039.2004.00315.x
Novel genes regulated by microphthalmia transcription factor in macrophages and osteoclasts
Meadows, N. A., Faulkner, G., Wells, C., Ravasi, T., Hume, D., Sankar, U., Hu, R., Ostrowski, M. and Cassady, A. (2004). Novel genes regulated by microphthalmia transcription factor in macrophages and osteoclasts. 26th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Seattle, WA, United States, 1-5 October 2004. Malden, MA, United States: Wiley-Blackwell. doi: 10.1002/jbmr.5650191306
Regulation of the murine TRACP gene promoter
Cassady, A. I., Luchin, A., Ostrowski, M. C. and Hume, David A. (2003). Regulation of the murine TRACP gene promoter. Washington: American Society for Bone and Mineral Research. doi: 10.1359/jbmr.2003.18.10.1901
Clues to interaction between CSF-1 and CSF-1R from specificity and structure
Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. Australian Society of Immunologists Meeting, Brisbane, 1-5 December, 2002.
Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.
Saleh, H, Walsh, N, Ravasi, T, Wells, C, Okazaki, Y, Carninci, P, Hayashizaki, Y, Hume, DA and Cassady, AI (2002). Microarray expression profiling of osteoclast-like cells differentiated with lipopolysaccharide.. 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, San Antonio Texas, Sep 20-24, 2002. WASHINGTON: AMER SOC BONE & MINERAL RES.
Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer
Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. International Conference on Structural Genomics, Berlin, 10-13 October, 2002.
Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide
Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, 29 September -3 October, 2002.
Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. Australian Society for Immunology Meeting, Brisbane, 1-5 December, 2002.
Pickering, D., Hume, D. A. and Young, P. R. (2001). Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.
Walsh, NC, Hume, DA and Cassady, AI (2001). Multiple promoters regulate differential expression of murine tartrate resistant acid phosphatase (TRAP).. WASHINGTON: AMER SOC BONE & MINERAL RES.
Cassady, AI, Merson, T, Suchting, S, Hong, TW and Hume, DA (2000). Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.. AMER SOC BONE & MINERAL RES.
Luchin, AI, Cassady, AI, Hume, DA and Ostrowski, MC (2000). Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.. AMER SOC CELL BIOLOGY.
Replication protein A binds preferentially to immunostimulatory oligonucleotides.
Stacey, K. J., Sester, D. P., Murphy, K. M., Sweet, M. J. and Hume, D. A. (2000). Replication protein A binds preferentially to immunostimulatory oligonucleotides.. -, -, -. Bethesda, MD United States: Federation of American Societies for Experimental Biology.
An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages
Himes, S. R., Goonetilleke, N. P. and Hume, D. A. (1999). An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival
Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, 22-26 September, 1999. Bethesda, Maryland: Society for Leukocyte Biology.
Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre
Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
Crystallisation of a mammalian purple acid phosphatase
Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., 7-11 February, 1999. Lorne: Lorne Aust..
Ostrowski, M., Erbe, L. S., Hume, D. A. and Smith, J. L. (1999). ETS-2 is a target for a CSF-1-Independent AKT signaling pathway preventing apoptosis in macrophages of motheaten-viable mice. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.
Immunostimulatory DNA promotes factor independent survival of macrophages
Sester, D. P., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). Immunostimulatory DNA promotes factor independent survival of macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Australian Society for Biochemistry & Molecular Biology.
Walsh, N., Angel, N., Williams, E. A., Cassady, A. I. and Hume, D. A. (1999). Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
Post-Golgi trafficking of TNF-a in macrophages
Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology In..
Cassady, A. I., Suchting, S. J., Angel, N., Merson, T. D. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. 21st Annual Meeting of the ASBMR, St Louis, USA, 30 Sept - 4 Oct, 1999. North Carolina, USA: American Society for Bone and Mineral Res..
Suchting, S. J., Merson, T. D., Angel, N., Cassady, A. I. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. ComBio 99, Conrad Jupiters, Gold Coast, 27th - 30th September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
Cassady, A. I., Walsh, N., Angel, N., Cahill, M. M., Forwood, M. R., Ostrowski, M. and Hume, D. A. (1999). Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. 9th Annual Scientific Meeting ANZBMS, Cairns, 30 June - 2 July, 1999. Sydney: ANZBMS.
Activation of macrophages by bacterial DNA
Stacey, K. J., Sweet, M. and Hume, D. A. (1996). Activation of macrophages by bacterial DNA. -, -, -. Oxford, United Kingdom: John Wiley & Sons .
Yue, Xie, Ross, Ian L., Browne, Catherine M., Lichanska, Agnieszka, Favot, Paula, Ostrowski, Michael C. and Hume, David A. (1996). Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1). Elsevier GmbH. doi: 10.1016/S0171-2985(96)80016-7
Molecular-Biology of Macrophage Differentiation
Hume, DA (1993). Molecular-Biology of Macrophage Differentiation. FEDERATION AMER SOC EXP BIOL.
Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester
Stacey, K. J., Fowles, L. F., Coleman, M. S., Ostrowski, M. and Hume, D. A. (1993). Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester. -, -, -. United Kingdom: John Wiley & Sons.
Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression
Favot, P, Fidler, IJ and Hume, DA (1993). Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression. FEDERATION AMER SOC EXP BIOL.
Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine
Pavli, P, Doe, WF and Hume, DA (1988). Enrichment and Characterization of Dendritic Cells From the Lamina Propria of Murine Intestine. W B SAUNDERS CO.
Pavli, P, Doe, WF and Hume, DA (1987). Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages. W B SAUNDERS CO.
Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection
Dixon, JE, Allan, JE, Ceredig, R, Hume, DA and Doherty, PC (1986). Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection. ADIS PRESS AUSTRALASIA P/L.
Hume, DA, Allan, W, Hogan, PG and Doe, WF (1986). Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9. W B SAUNDERS CO.
The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract
Hume, DA, Allan, W, Hogan, PG and Doe, WF (1985). The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract. ADIS PRESS AUSTRALASIA P/L.
Assays for Interleukin-3 (Multi-Csf) Are Not Specific
Hapel, AJ, Warren, HS, Hume, DA, Allan, W and Osborne, JM (1984). Assays for Interleukin-3 (Multi-Csf) Are Not Specific. MARY ANN LIEBERT INC PUBL.
Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues
Hume, DA and Gordon, S (1983). Immunohistochemical Localization of a Macrophage-Specific Antigen in Mouse-Tissues. PROC AUST BIOCHEMICAL SOC.
Hume, DA and Weidemann, MJ (1977). Effect of Sulfhydryl Blockage On Stimulation of Thymocyte Glucose-Transport by Concanavalin-A and Ionophore-A23187. PROC AUST BIOCHEMICAL SOC.
Hume, DA and Weidemann, MJ (1977). Mitogenic Stimulation of Thymocyte Glucose-Transport Alters Sensitivity of Glucose Carrier to N-Ethylmaleimide and Phloretin. WALTER DE GRUYTER & CO.
CSF1R_FRed_SupplementaryVideos
Irvine, Katharine, Hume, David and Sehgal, Anuj (2020). CSF1R_FRed_SupplementaryVideos. The University of Queensland. (Dataset) doi: 10.14264/8c6d4ba
Macrophage Biology in Health and Disease
(2022–2026) NHMRC Investigator Grants
Macrophage control of mammalian growth and development
(2021–2024) ARC Discovery Projects
CSF1 Therapy for Chronic Liver Disease
(2019–2022) NHMRC Project Grant
CSF1R and the control of microglial function
(2019–2021) NHMRC Project Grant
(2019–2021) Mater Foundation
Osteal macrophages as therapeutic targets for fracture repair
(2018–2020) NHMRC Project Grant
Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages
(2008–2009) Cancer Council Queensland
Cellular Activation and Apoptosis in Response to Foreign Cytoplasmic DNA
(2007–2010) NHMRC Project Grant
Role of bone-associated macrophages in bone remodelling and bone disease
(2007–2009) NHMRC Project Grant
The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
(2007–2009) NHMRC Project Grant
Regulation of human fibrillin genes in cardiovascular disease
(2007–2008) National Heart Foundation of Australia
Molecular genetics of the host response defect in cystic fibrosis
(2006–2008) NHMRC Project Grant
The role of DEP-1 as a tumour suppressor in breast cancer
(2006–2007) Queensland Cancer Fund
Human macrophage transcriptional network
(2005–2008) Riken Genomic Sciences Center
Transcription control of the c-fms gene
(2005–2007) NHMRC Project Grant
Developmental Imaging Facility
(2005) ARC Linkage Infrastructure, Equipment and Facilities
Dynamic Imaging Facility for Cancer Biology
(2004–2011) Australian Cancer Research Foundation
(2004–2007) ARC Linkage Projects
Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62
(2004–2006) NHMRC Project Grant
TLR9 And The Response To Foreign DNA
(2004–2006) NHMRC Project Grant
ARC Research Network in Microarray Technology
(2004) ARC Seed Funding for Research Networks
Gene expression profiling and de novo transcriptome sequencing using geneballs
(2003–2006) ARC Linkage Projects
Molecular Genetics Of Macrophage Activation
(2003–2005) NHMRC Project Grant
Molecular genetics of cystic fibrosis
(2003–2005) NHMRC Project Grant
Molecular genetics of macrophage activation
(2003–2005) NHMRC Project Grant - Standard
Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
(2003–2004) NHMRC Project Grant
(2003) NHMRC Equipment Grant
Alternative Splicing in the Mouse Transcriptome
(2003) ARC Discovery Projects
Molecular Regulators of Cytokine Secretion
(2003) University of Queensland Research Development Grants Scheme
Targeted Structural Genomics of Macrophage Proteins
(2003) University of Queensland Research Development Grants Scheme
Education and training program
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2008) CRC for Chronic Inflammatory Diseases
(2002–2006) United States National Institutes of Health
Osteoclast-specific gene regulation
(2002–2004) NHMRC Project Grant
Transciptional regulation of the c-fms (CFS-1R) gene in macrophages
(2002–2004) NHMRC Project Grant
Defining the human and mammalian methylomes and implications for medical research
(2002) University of Queensland Research Development Grants Scheme
Approaches to manipulating the expression of the c-fms gene
(2001–2002) Sangamo Biosciences Inc.
Transgenic animal studies of the function of artificial zinc finger transcription factors
(2001–2002) Sangamo Biosciences Inc.
MJ Research Tetrad - 4 x 96well block thermocycler
(2001) Ramaciotti Foundation
Targeted structural genomics of proteins involved in macrophage activation and differentiation.
(2001) University of Queensland Small Grants Scheme
Genes controlling the development of lung disease in cystic fibrosis mutant mice
(2000–2002) NHMRC Project Grant
Mechanisms of macrophage activation by immunostimulatory DNA
(2000–2002) NHMRC Project Grant
The role of the microphthalmia transcription factor family in macrophage differentiation
(2000–2002) NHMRC Project Grant
Control of osteociast differentiation
(2000) Mayne Bequest Fund
Regulation of the Tartrate-Resistant Acid Phosphatase Gene.
(2000) ARC Australian Research Council (Small grants)
Genetic interactions that regulate the response of macrophages to bacterial lipopolysaccharide
(1999–2001) Merck Genome Research Institute
Human tartrate-resistant purple acid phosphatase: structure and function
(1999–2001) NHMRC Project Grant
Signal transduction from the macrophage colony-stimulating factor receptor
(1999–2000) Queensland Cancer Fund
Transcriptional regulation of the macrophage colony stimulating factor receptor (c-fms) gene
(1999–2000) NHMRC Project Grant
Function and regulation of the tartrate resistant acid phosphatase gene
(1999) Mayne Bequest Fund
Mechanisms of action of CpG DNA as an activator of macrophage function
(1999) Mayne Bequest Fund
Transcriptional Regulation of the Macrophage Colony Stimulating Factor Receptor (c-fms) Gene
(1998–2000) NHMRC Project Grant
Genes controlling the development of lung disease in normal and cystic fibrosis mice
(1997–1999) NHMRC Project Grant
Crystallisation of tartrate resistant acid phosphatase
(1997–1998) Johnson & Johnson Research Pty Ltd
Development of candidate drugs for the treatment of osteoporosis
(1997) Merck Sharp & Dohme Australia
(1997) NHMRC Equipment Grant
(1997) Ramaciotti Foundation
Regulation of the HIV-1-LTR in macrophages
(1997) NHMRC Extended Epidemiology Project Grant
Function and regulation of the tartrate-resistant acid phosphatase gene
(1996–1998) NHMRC Project Grant
Protein tyrosine phosphatases in macrophages
(1996–1998) Queensland Cancer Fund
Regulation of the urokinase plasminogen activator gene by macrophaghe colony-stimulating factor
(1996–1998) NHMRC Project Grant
Macrophage DNA recepter project.
(1996) CRC for Vaccine Technology
(1996) NHMRC Equipment Grant
Regulation of HIV-1-LTR in macrophages
(1995–1997) NHMRC Project Grant - HIV/AIDS (CARG)
The role of c-fms and macrophage colony stimulating factor (CSF-1) in tumor progression
(1995–1997) Queensland Cancer Fund
(1995) Australian Cancer Foundation for Medical Research
Conduct several trial projects using CSF-1 in-vivo
(1989) Genetics Institute
Macrophage colony stimulating factor in the treatment of non-alcoholic fatty liver disease
Doctor Philosophy — Principal Advisor
Other advisors:
Erythroid iron metabolism and its effect on systemic iron homeostasis
Doctor Philosophy — Principal Advisor
Other advisors:
Regulation and function of CSF1R-dependent tissue macrophage populations.
Doctor Philosophy — Principal Advisor
Other advisors:
Transcriptional regulation of the mouse Csf1r locus
Doctor Philosophy — Principal Advisor
Other advisors:
Macrophage-driven lipid metabolism in health and disease
Doctor Philosophy — Associate Advisor
Other advisors:
Preclinical modelling of chronic GVHD in the brain to instruct novel therapies
Doctor Philosophy — Associate Advisor
Functions of CSF1R signalling in inflammation.
Doctor Philosophy — Associate Advisor
Other advisors:
Pathogen Promoters of Squamous Epithelial Cancer
Doctor Philosophy — Associate Advisor
(2023) Doctor Philosophy — Principal Advisor
Other advisors:
The role of macrophages in the regulation of systemic metabolism
(2023) Doctor Philosophy — Principal Advisor
Other advisors:
Regulation and Function of Schlafen in Macrophage Biology
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
THE STRUCTURAL BASIS FOR INTERACTION BETWEEN COLONY- STIMULATING FACTOR-1 AND ITS RECEPTOR, CSF-1R
(2007) Doctor Philosophy — Principal Advisor
Other advisors:
TRANSCRIPTIONAL REGULATION OF THE c-fms PROMOTER BY THE ETS FAMILY OF TRANSCRIPTION FACTORS
(2007) Doctor Philosophy — Principal Advisor
Other advisors:
FUNCTIONAL CHARACTERISATION OF MACROPHAGE-SPECIFIC TRANSCRIPTS
(2006) Doctor Philosophy — Principal Advisor
MECHANISMS OF INTERFERON-GAMMA PRIMING OF MACROPHAGE ACTIVATION BY CpG DNA
(2005) Doctor Philosophy — Principal Advisor
Study of gene expression profile of osteoclasts
(2004) Master Science — Principal Advisor
THE EXPRESSIONS AND FUNCTIONS OF G3BPs IN MACROPHAGES
(2004) Doctor Philosophy — Principal Advisor
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
(2004) Doctor Philosophy — Principal Advisor
Other advisors:
MECHANISMS OF ACTION OF BACTERIAL DNA ON MACROPHAGE ACTIVATION
(2003) Doctor Philosophy — Principal Advisor
Other advisors:
THE FUNCTION AND REGULATION OF TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP)
(2003) Doctor Philosophy — Principal Advisor
Transcriptional regulation of c-fms gene expression
(2003) Doctor Philosophy — Principal Advisor
(2021) Master Philosophy — Associate Advisor
Characterisation of Myeloid Cells in the Peritoneal Foreign Body Response: Evidence for Phenotypic Plasticity
(2012) Doctor Philosophy — Associate Advisor
Other advisors:
(2010) Doctor Philosophy — Associate Advisor
Other advisors:
Cellular activation and death in response to cytoplasmic DNA
(2009) Doctor Philosophy — Associate Advisor
Other advisors:
Role of macrophages, residing on the bone surface, in bone remodelling and repair
(2009) Doctor Philosophy — Associate Advisor
Other advisors:
Short Sequence Tags Reveal Global Transcription Of Repetitive Elements In Mammalian Genomes
(2009) Doctor Philosophy — Associate Advisor
FUNCTIONAL CHARACTERISATION OF THE ROLE OF PROTEIN TYROSINE PHOSPHATASE CD148 IN MACROPHAGES
(2007) Doctor Philosophy — Associate Advisor
MOLECULAR AND FUNCTIONAL CHARACTERISATION OF POTENTIAL MURINE RENAL STEM CELLS
(2006) Doctor Philosophy — Associate Advisor
THE BIOLOGY OF NOD2
(2006) Doctor Philosophy — Associate Advisor
Other advisors:
THE IMPORTANCE OF EPIGENETICS IN MAMMALS
(2006) Doctor Philosophy — Associate Advisor
Other advisors:
THE ROLE OF MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN OSTEOCLAST GENE REGULATION
(2006) Doctor Philosophy — Associate Advisor
CELLULAR RESPONSES TO IMMUNOSTIMULATORY DNA
(2005) Doctor Philosophy — Associate Advisor
Other advisors:
SHADES OF DOMAINS: BIOINFORMATIC IDENTIFICATION OF PROTEIN DOMAIN SUBTYPES AND CORRELATION WITH FUNCTIONAL SPECIFICITY
(2005) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701