Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages (2008–2009)
HDAC inhibitors are anti-cancer drugs that kill rapidly growing cells (like cancer cells). These drugs are also beneficial in inflammatory diseases such as Rheumatoid Arthritis and sepsis (infections of the blood). However, it is unknown how they reduce inflammation. In this project we aim to understand how HDAC inhibitors act as anti-inflammatory agents and to design new HDAC inhibitors with reduced side effects for the treatment of inflammatory diseases.