Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M, Ho, Eileen, Caruso, Melanie, Patkar, Omkar L, Sehgal, Anuj, Millard, Susan M, Hume, David A and Pettit, Allison R (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology. doi: 10.1093/jleuko/qiae077
Journal Article: A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria
Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
A macrophage-centric holistic view of postnatal development
(2024–2026) ARC Discovery Projects
Macrophage-driven lipid metabolism in health and disease - mechanisms and therapeutic opportunities
(2022–2024) NHMRC IDEAS Grants
Macrophage control of mammalian growth and development
(2021–2024) ARC Discovery Projects
Functions of CSF1R signalling in inflammation.
Doctor Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
(2022) Master Philosophy
Investigation of Matrix Regulation of Wound Repair
Doctor Philosophy
Genetic and immunohistochemistry tools to visualize rat macrophages in situ
Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6
The impact of CAGE data on understanding macrophage transcriptional biology
Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription. (pp. 227-243) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814241359
The impact of CAGE data on the understanding of macrophage transcriptional biology
Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription. (pp. 227-244) edited by Piero Carninci. Singapore: Pan Stanford Publishing.
Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M, Ho, Eileen, Caruso, Melanie, Patkar, Omkar L, Sehgal, Anuj, Millard, Susan M, Hume, David A and Pettit, Allison R (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology. doi: 10.1093/jleuko/qiae077
Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
Gracen, Lucy, Muthukumara, Withma, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine M., Williams, Suzanne, Puri, Gaurav, Valery, Patricia C., Hayward, Kelly L. and Powell, Elizabeth E. (2023). Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists. Annals of Hepatology, 28 (6) 101142, 101142. doi: 10.1016/j.aohep.2023.101142
Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052
Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312
Thai, Le May, O'Reilly, Liam, Reibe-Pal, Saskia, Sue, Nancy, Holliday, Holly, Small, Lewin, Schmitz-Peiffer, Carsten, Dhenni, Rama, Wang-Wei Tsai, Vicky, Norris, Nicholas, Yau, Belinda, Zhang, Xuan, Lee, Kailun, Yan, Chenxu, Shi, Yan-Chuan, Kebede, Melkam A., Brink, Robert, Cooney, Gregory J., Irvine, Katharine M., Breit, Samuel N., Phan, Tri G., Swarbrick, Alexander and Biden, Trevor J. (2023). β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling. iScience, 26 (4) 106477, 1-23. doi: 10.1016/j.isci.2023.106477
Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784
Gracen, Lucy, Hayward, Kelly L., Aikebuse, Melanie, Russell, Anthony, O’Beirne, James, McPhail, Steven, Irvine, Katharine M., Williams, Suzanne, Valery, Patricia C. and Powell, Elizabeth E. (2022). Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes. BMC Health Services Research, 22 (1) 487, 1-11. doi: 10.1186/s12913-022-07808-7
CSF1R as a therapeutic target in bone diseases: obvious but not so simple
Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4
Canivet, Clémence M., Costentin, Charlotte, Irvine, Katharina M., Delamarre, Adèle, Lannes, Adrien, Sturm, Nathalie, Oberti, Frederic, Patel, Preya J., Decaens, Thomas, Irles-Depé, Marie, Fouchard, Isabelle, Hermabessière, Paul, Roux, Marine, Barthelon, Justine, Calès, Paul, Powell, Elizabeth E., de Ledinghen, Victor and Boursier, Jérôme (2022). Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD. Hepatology, 77 (3), n/a-n/a. doi: 10.1002/hep.32665
Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis
Gracen, Lucy, Hayward, Kelly L., Irvine, Katharine M., Valery, Patricia C. and Powell, Elizabeth E. (2022). Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis. Journal of Hepatology, 77 (4), 1219-1221. doi: 10.1016/j.jhep.2022.06.016
Ratnasekera, Isanka U., Johnson, Amy, Powell, Elizabeth E., Henderson, Andrew, Irvine, Katharine M. and Valery, Patricia C. (2022). Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study. Medicine, 101 (20) 00010, e29217. doi: 10.1097/MD.0000000000029217
Hayward, Kelly L., Bansal, Vikas, Valery, Patricia C., Irvine, Katharine M., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2022). Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis. Hepatology Communications, 6 (11), 3281-3282. doi: 10.1002/hep4.1999
Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555
Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 100386. doi: 10.1016/j.jhepr.2021.100386
Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387
Johnson, Amy L., Ratnasekera, Isanka U., Irvine, Katharine M., Henderson, Andrew, Powell, Elizabeth E. and Valery, Patricia C. (2021). Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study. BMJ Open Gastroenterology, 8 (1) e000695. doi: 10.1136/bmjgast-2021-000695
Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z
Irvine, Katharine M., Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Williams, Suzanne, Russell, Anthony and Powell, Elizabeth E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific Reports, 11 (1) 2858, 1-8. doi: 10.1038/s41598-021-82315-z
Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058
Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Li, Catherine, Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2021). Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety. Pharmaceuticals, 14 (12) 1207. doi: 10.3390/ph14121207
Johnson, Amy L., Hayward, Kelly L., Patel, Preya, Horsfall, Leigh U., Cheah, Alvin Ee Zhiun, Irvine, Katharine M., Russell, Anthony W., Stuart, Katherine A., Williams, Sue, Hartel, Gunter, Valery, Patricia C. and Powell, Elizabeth E. (2021). Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests. Hepatology Communications, 6 (4), 728-739. doi: 10.1002/hep4.1852
Sehgal, Anuj, Irvine, Katharine M. and Hume, David A. (2021). Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Seminars in Immunology, 54 101509, 101509. doi: 10.1016/j.smim.2021.101509
Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Wu, Andy C., Kaur, Simranpreet, Sun, Lucas W.H., Williams, Kyle, Sandrock, Cheyenne, Ng, Pei Ying, Irvine, Katharine M., Bartnikowski, Michal, Glatt, Vaida, Pavlos, Nathan J. and Pettit, Allison R. (2021). Osteal macrophages support osteoclast‐mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model. Journal of Bone and Mineral Research, 36 (11), 2214-2228. doi: 10.1002/jbmr.4413
Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936
Hayward, Kelly L., McKillen, Benjamin J., Horsfall, Leigh U., McIvor, Carolyn, Liew, Katerina, Sexton, Jo, Johnson, Amy L., Irvine, Katharine M., Valery, Patricia C., McPhail, Steven M., Britton, Laurence J., Rosenberg, William, Weate, Ingrid, Williams, Sue and Powell, Elizabeth E. (2021). Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care. Internal Medicine Journal, 52 (10) imj.15422, 1749-1758. doi: 10.1111/imj.15422
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation
Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605
The mononuclear phagocyte system of the rat
Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136
Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268
Transcriptomic analysis of rat macrophages
Pridans, Clare, Irvine, Katharine M, Davis, Gemma M, Lefevre, Lucas, Bush, Stephen J and Hume, David A (2021). Transcriptomic analysis of rat macrophages. Frontiers in Immunology, 11 594594. doi: 10.3389/fimmu.2020.594594
Grabert, Kathleen, Sehgal, Anuj, Irvine, Katharine M., Wollscheid-Lengeling, Evi, Ozdemir, Derya D., Stables, Jennifer, Luke, Garry A., Ryan, Martin D., Adamson, Antony, Humphreys, Neil E., Sandrock, Cheyenne J., Rojo, Rocio, Verkasalo, Veera A., Mueller, Werner, Hohenstein, Peter, Pettit, Allison R., Pridans, Clare and Hume, David A. (2020). A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system. Journal of Immunology, 205 (11), 3154-3166. doi: 10.4049/jimmunol.2000835
Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2020). Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis. Internal Medicine Journal, 50 (9), 1142-1146. doi: 10.1111/imj.14986
McKillen, Benjamin J., Powell, Elizabeth E., Horsfall, Leigh U., Clouston, Andrew D., Brown, Nigel N., Elangovan, Harendran, Patel, Preya J., Valery, Patricia C., Irvine, Katharine M., Bernard, Anne and Hayward, Kelly L. (2020). Longitudinal change in simple scores identifies fibrosis status in people with nonalcoholic fatty liver disease. Journal of Clinical Gastroenterology, 54 (7), 661-662. doi: 10.1097/MCG.0000000000001372
Ahn, Sang Bong, Powell, Elizabeth E., Russell, Anthony, Hartel, Gunter, Irvine, Katharine M., Moser, Chris and Valery, Patricia C. (2020). Type 2 diabetes: a risk factor for hospital readmissions and mortality in Australian patients with cirrhosis. Hepatology Communications, 4 (9) hep4.1536, 1279-1292. doi: 10.1002/hep4.1536
Valery, Patricia C., Clark, Paul J., Pratt, Gregory, Bernardes, Christina M., Hartel, Gunter, Toombs, Maree, Irvine, Katharine M. and Powell, Elizabeth E. (2020). Hospitalisation for cirrhosis in Australia: disparities in presentation and outcomes for Indigenous Australians. International Journal for Equity in Health, 19 (1) 27, 27. doi: 10.1186/s12939-020-1144-6
Irvine, Katharine M., Bligh, Larissa N. and Kumar, Sailesh (2019). Association between the fetal cerebroplacental ratio and biomarkers of hypoxia and angiogenesis in the maternal circulation at term. European Journal of Obstetrics and Gynecology and Reproductive Biology, 245, 198-204. doi: 10.1016/j.ejogrb.2019.11.018
Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r
Janubhai Patel, Preya, Chieh-Yu Cheng, Johnson, Banh, Xuan, Gracen, Lucy, Radford-Smith, Daniel, Hossain, Fabrina, Horsfall, Leigh Ula, Lee Hayward, Kelly, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine Anne, Russell, Anthony William, Valery, Patricia Casarolli, Clouston, Andrew Donald, Irvine, Katharine Margaret, Bernard, Anne and Powell, Elizabeth Ellen (2019). Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores. Clinical Gastroenterology and Hepatology, 18 (3), 710-718.e4. doi: 10.1016/j.cgh.2019.07.036
Phenotypic impacts of CSF1R deficiencies in humans and model organisms
Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019). Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, 107 (2) JLB.MR0519-143R, 205-219. doi: 10.1002/jlb.mr0519-143r
Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Martin, Jennifer H. and Powell, Elizabeth E. (2019). Reply. Hepatology Communications, 3 (9), 1283-1284. doi: 10.1002/hep4.1398
Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768
Genz, Berit, Coleman, Miranda A., Irvine, Katharine M., Kutasovic, Jamie R., Miranda, Mariska, Gratte, Francis D., Tirnitz-Parker, Janina E. E., Olynyk, John. K., Calvopina, Diego A., Weis, Anna, Cloonan, Nicole, Robinson, Harley, Hill, Michelle M., Al-Ejeh, Fares and Ramm, Grant A. (2019). Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells. Scientific Reports, 9 (1) 8541, 8541. doi: 10.1038/s41598-019-44865-1
Hayward, Kelly L., Patel, Preya J., Valery, Patricia C., Horsfall, Leigh U., Li, Catherine Y., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2019). Medication‐related problems in outpatients with decompensated cirrhosis: Opportunities for harm prevention. Hepatology Communications, 3 (5) hep4.1334, 620-631. doi: 10.1002/hep4.1334
Causes and consequences of innate immune dysfunction in cirrhosis
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 (FEB) 293, 293. doi: 10.3389/fimmu.2019.00293
The mononuclear phagocyte system: the relationship between monocytes and macrophages
Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019). The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 (2), 98-112. doi: 10.1016/j.it.2018.11.007
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 (APR) 818, 818. doi: 10.3389/fimmu.2019.00818
ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages
Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246
Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018). A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 (8), 893-905. doi: 10.1002/hep4.1208
Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274
Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Russell, Anthony William and Powell, Elizabeth Ellen (2018). Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control. Journal of Diabetes and its Complications, 32 (8), 799-804. doi: 10.1016/j.jdiacomp.2018.05.008
Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017
Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2018). Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 (2), 144-151. doi: 10.1111/imj.13667
Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018). Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78, 80-94. doi: 10.1016/j.metabol.2017.09.002
Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease
Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017). Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685, 7927685-8. doi: 10.1155/2017/7927685
Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis
Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017). Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 (40), 7321-7331. doi: 10.3748/wjg.v23.i40.7321
Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017). Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 (8), 952-955. doi: 10.1111/imj.13505
Hayward, Kelly L., Martin, Jennifer H., Cottrell, W. Neil, Karmakar, Antara, Horsfall, Leigh U., Patel, Preya J., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Valery, Patricia C. (2017). Patient-oriented education and medication management intervention for people with decompensated cirrhosis: study protocol for a randomized controlled trial. Trials, 18 (1) 339, 339. doi: 10.1186/s13063-017-2075-4
Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017). Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 (26) e6761, e6761. doi: 10.1097/MD.0000000000006761
O'Leary, Caroline A., Sedhom, Mamdouh, Reeve-Johnson, Mia, Mallyon, John and Irvine, Katharine M. (2017). Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus. Veterinary Immunology and Immunopathology, 186, 1-8. doi: 10.1016/j.vetimm.2016.12.011
El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017). Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 (4), 407-418. doi: 10.1071/AH15225
Irvine, Katharine M., Wockner, Leesa F., Hoffmann, Isabel, Horsfall, Leigh U., Fagan, Kevin J., Bijin, Veonice, Lee, Bernett, Clouston, Andrew D., Lampe, Guy, Connolly, John E. and Powell, Elizabeth E. (2016). Multiplex serum protein analysis identifies novel biomarkers of advanced fibrosis in patients with chronic liver disease with the potential to improve diagnostic accuracy of established biomarkers. PLoS ONE, 11 (11) 167001, e0167001. doi: 10.1371/journal.pone.0167001
Prevalence of medication discrepancies in patients with cirrhosis: A pilot study
Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Horsfall, Leigh U., Tallis, Caroline J., Chachay, Veronique S., Ruffin, Brittany J., Martin, Jennifer H. and Powell, Elizabeth E. (2016). Prevalence of medication discrepancies in patients with cirrhosis: A pilot study. BMC Gastroenterology, 16 (1) 114, 114. doi: 10.1186/s12876-016-0530-4
Gadd, Victoria L., Patel, Preya J., Jose, Sara, Horsfall, Leigh, Powell, Elizabeth E. and Irvine, Katharine M. (2016). Altered peripheral blood monocyte phenotype and function in chronic liver disease: implications for hepatic recruitment and systemic inflammation. PLoS One, 11 (6) e0157771, e0157771. doi: 10.1371/journal.pone.0157771
Irvine, Katharine M., Xuan Banh, Gadd, Victoria L., Wojcik, Kyle K., Ariffin, Juliana K., Jose, Sara, Lukowski, Samuel, Baillie, Gregory J., Sweet, Matthew J. and Powell, Elizabeth E. (2016). CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites. JCI Insight, 1 (8) e86914, e86914. doi: 10.1172/jci.insight.86914
El-Atem, N. A., Wojcik, K., Horsfall, L., Irvine, K. M., Johnson, T., McPhail, S. M. and Powell, E. E. (2016). Patterns of service utilisation within Australian hepatology clinics: high prevalence of advanced liver disease. Internal Medicine Journal, 46 (4), 420-426. doi: 10.1111/imj.13008
Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016). Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 (3), 524-538. doi: 10.1016/j.ajpath.2015.10.029
Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061
Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Hayward, Kelly L., Powell, Elizabeth E., Irvine, Katharine M. and Martin, Jennifer H. (2015). Can paracetamol (acetaminophen) be administered to patients with liver impairment?. British Journal of Clinical Pharmacology, 81 (2), 210-222. doi: 10.1111/bcp.12802
Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7
Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes
Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17
Irvine, Katharine M., Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin J., Horsfall, Leigh U., Fletcher, Linda M., Ungerer, Jacobus P. J., Pretorius, Carel J., Miller, Gregory C., Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease. Liver International, 36 (3), 370-377. doi: 10.1111/liv.12896
Response to ELF cut-off points: aetiology is also a relevant factor
Powell, Elizabeth E., Irvine, Katharine M., Fagan, Kevin J., Ballard, Emma and O'Rourke, Peter (2015). Response to ELF cut-off points: aetiology is also a relevant factor. Liver International, 35 (7), 1921-1921. doi: 10.1111/liv.12822
Fagan, Kevin J., Pretorius, Carel J., Horsfall, Leigh U., Irvine, Katharine M., Wilgen, Urs, Choi, Kihoon, Fletcher, Linda M., Tate, Jill, Melino, Michelle, Nusrat, Sharmin, Miller, Gregory C., Clouston, Andrew D., Ballard, Emma, O'Rourke, Peter, Lampe, Guy, Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2015). ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. Liver International, 35 (6), 1673-1681. doi: 10.1111/liv.12760
Fagan, Kevin J., Rogers, Geraint B., Melino, Michelle, Arthur, Dionne M., Costello, Mary-Ellen, Morrison, Mark, Powell, Elizabeth E. and Irvine, Katharine M. (2015). Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection. PLoS One, 10 (3) e0120642, e0120642. doi: 10.1371/journal.pone.0120642
Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration
Irvine, Katharine M., Skoien, Richard, Bokil, Nilesh J., Melino, Michelle, Thomas, Gethin P., Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M., Sweet, Matthew J., Clouston, Andrew D. and Powell, Elizabeth E. (2014). Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration. World Journal of Gastroenterology, 20 (47), 17851-17862. doi: 10.3748/wjg.v20.i47.17851
Fagan, K. J., Zhao, Eileen Y., Horsfall, L. U., Ruffin, Brittany J., Kruger, Mark S., McPhail, S. M., O'Rourke, Peter, Ballard, Emma, Irvine, K. M. and Powell, E. E. (2014). Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?. Internal Medicine Journal, 44 (9), 865-872. doi: 10.1111/imj.12491
Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers
Fagan K.J., Irvine K.M., McWhinney B.C., Fletcher L.M., Horsfall L.U., Johnson L., O'Rourke P., Martin J., Scott I., Pretorius C.J., Ungerer J.P.J. and Powell E.E. (2014). Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterology, 14 (1) 97, 1-6. doi: 10.1186/1471-230X-14-97
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
Gadd, Victoria L., Skoien, Richard, Powell, Elizabeth E., Fagan, Kevin J., Winterford, Clay, Horsfall, Leigh, Irvine, Katharine and Clouston, Andrew D. (2014). The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology, 59 (4), 1393-1405. doi: 10.1002/hep.26937
New paradigms in the histopathology of NAFLD
Clouston, Andrew D., Gadd, Victoria L., Irvine, Katharine M. and Powell, Elizabeth E. (2014). New paradigms in the histopathology of NAFLD. Current Hepatitis Reports, 13 (2), 81-87. doi: 10.1007/s11901-014-0214-x
Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959
Fagan, K. J., Irvine, K. M., Kumar, S., Bates, A., Horsfall, L. U., Feeney, G. F. and Powell, E. E. (2013). Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention. Internal Medicine Journal, 43 (10), 1096-1102. doi: 10.1111/imj.12229
Fagan, Kevin J., Irvine, Katharine M., McWhinney, Brett C., Fletcher, Linda M., Horsfall, Leigh U., Johnson, Lambro A., Clouston, Andrew D., Jonsson, Julie R., O'Rourke, Peter, Martin, Jennifer, Pretorius, Carel J., Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2013). BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin. Alcoholism Clinical and Experimental Research, 37 (10), 1771-1778. doi: 10.1111/acer.12143
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
Gadd, Victoria L., Melino, Michelle, Roy, Sandrine, Horsfall, Leigh, O'Rourke, Peter, Williams, Millicent R., Irvine, Katharine M., Sweet, Matthew J., Jonsson, Julie R., Clouston, Andrew D. and Powell, Elizabeth E. (2013). Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver International, 33 (4), 569-579. doi: 10.1111/liv.12050
Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020
Liver repercussions of defective gut surveillance
Irvine, Katharine M., Schroder, Elizabeth E. and Powell, Elizabeth E. (2012). Liver repercussions of defective gut surveillance. Hepatology, 56 (3), 1174-1177. doi: 10.1002/hep.25944
Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew and Thomas, Ranjeny (2012). Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes. Diabetes, 61 (5), 1281-1290. doi: 10.2337/db11-1549
Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109
Histone deacetylases as regulators of inflammation and immunity
Shakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011). Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 (7), 335-343. doi: 10.1016/j.it.2011.04.001
Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723
Kawaji, H, Severin, J, Lizio, M, Forrest, ARR, van Nimwegen, E, Rehli, M, Schroder, K, Irvine, K, Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, CO (2011). Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research, 39 (Supp. 1), D856-D860. doi: 10.1093/nar/gkq1112
Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363
Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)
Taft, Ryan J., Glazov, Evgeny A., Cloonan, Nicole, Simons, Cas, Stephen, Stuart, Faulkner, Geoffrey J., Lassmann, Timo, Forrest, Alistair R. R., Grimmond, Sean M., Schroder, Kate, Irvine, Katharine, Arakawa, Takahiro, Nakamura, Mari, Kubosaki, Atsutaka, Hayashida, Kengo, Kawazu, Chika, Murata, Mitsuyoshi, Nishiyori, Hiromi, Fukuda, Shiro, Kawai, Jun, Daub, Carsten O., Hume, David A., Suzuki, Harukazu, Orlando, Valerio, Carninci, Piero, Hayashizaki, Yoshihide and Mattick, John S. (2009). Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009). Nature Genetics, 41 (7), 859-859. doi: 10.1038/ng0709-859a
Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009). Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 (3), 326-337. doi: 10.1111/j.1365-2567.2008.02979.x
The regulated retrotransposon transcriptome of mammalian cells
Faulkner, Geoffrey J., Kimura, Yasumasa, Daub, Carsten O., Wani, Shivangi, Plessy, Charles, Irvine, Katharine M., Schroder, Kate, Cloonan, Nicole, Steptoe, Anita L., Lassmann, Timo, Waki, Kazunori, Hornig, Nadine, Arakawa, Takahiro, Takahashi, Hazuki, Kawai, Jun, Forrest, Alistair R. R., Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A., Orlando, Valerio, Grimmond, Sean M. and Carninci, Piero (2009). The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics, 41 (5), 563-571. doi: 10.1038/ng.368
Suzuki, H, Forrest, ARR, van Nimwegen, E, Daub, CO, Balwierz, PJ, Irvine, KM, Lassmann, T, Ravasi, T, Hasegawa, Y, de Hoon, MJL, Katayama, S, Schroder, K, Carninci, P, Tomaru, Y, Kanamori-Katayama, M, Kubosaki, A, Akalin, A, Ando, Y, Arner, E, Asada, M, Asahara, H, Bailey, T, Bajic, VB, Bauer, D, Beckhouse, AG, Bertin, N, Bjorkegren, J, Brombacher, F, Bulger, E ... Riken Omics Science Center (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics, 41 (5), 553-562. doi: 10.1038/ng.375
Tiny RNAs associated with transcription start sites in animals
Taft, RJ, Glazov, EA, Cloonan, N, Simons, C, Stephen, S, Faulkner, GJ, Lassmann, T, Forrest, ARR, Grimmond, SM, Schroder, K, Irvine, K, Arakawa, T, Nakamura, M, Kubosaki, A, Hayashida, K, Kawazu, C, Murata, M, Nishiyori, H, Fukuda, S, Kawai, J, Daub, CO, Hume, DA, Suzuki, H, Orlando, V, Carninci, P, Hayashizaki, Y and Mattick, JS (2009). Tiny RNAs associated with transcription start sites in animals. Nature Genetics, 41 (5), 572-578. doi: 10.1038/ng.312
Data-driven normalization strategies for high-throughput quantitative RT-PCR
Mar, Jessica C., Kimura, Yasumasa, Schroder, Kate, Irvine, Katherine M., Hayashizaki, Yoshihide, Suzuki, Harukazu, Hume, David and Quackenbush, John (2009). Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics, 10 (1) 110, 110.1-110.10. doi: 10.1186/1471-2105-10-110
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009). The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 (4) R40. doi: 10.1186/gb-2009-10-4-r40
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009). Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 (2), 278-288. doi: 10.1189/jlb.0808497
Maeda, Norihiro, Nishiyori, Hiromi , Nakamura, Mari , Kawazu, Chika, Murata, Mitsuyoshi , Sano, Hiromi, Hayashida, Kengo, Fukuda, Shiro, Tagami, Michihira, Hasegawa, Akira, Murakami, Kayoko, Schroder, Kate, Irvine, Katharine, Hume, David A., Hayashizaki, Yoshihide, Carninci, Piero and Suzuki, Harukazu (2008). Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. BioTechniques, 45 (1), 95-97. doi: 10.2144/000112814
Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 (6), 3495-3503. doi: 10.4049/jimmunol.179.6.3495
Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007). PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 (6), 1577-1590. doi: 10.1189/jlb.0107036
Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007). Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 (10), 6557-6566. doi: 10.4049/jimmunol.178.10.6557
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006). A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 (11), 1921-1923. doi: 10.1096/fj.06-5848fje
Rasputin, more promiscuous than ever: a review of G3BP
Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004). Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 (10), 1065-1077. doi: 10.1387/ijdb.041893ki
Batoon, Lena, Keshvari, Sahar, Irvine, Katharine, Caruso, Melanie, Patkar, Omkar, Sehgal, Anuj, Millard, Susan, Hume, David and Pettit, Allison (2023). Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer. 2022 Annual Meeting of the American Society for Bone and Mineral Research, Austin, TX, United States, 9-12 September 2022. Hoboken, NJ, United States: Wiley-Blackwell.
Iyer, Abishek, Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J. and Fairlie, David P. (2019). Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation. Experimental Biology Meeting (EB), Orlando Fl, Apr 06-09, 2019. HOBOKEN: WILEY.
Irvine, Katharine, Genz, Berit, Clouston, Andrew D. and Hume, David (2018). Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco, CA USA, 9-13 November 2018. Hoboken, NJ USA: Wiley.
Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores
Patel, Preya, Cheng, Johnson Chieh-Yu, Banh, Xuan, Hossain, Fabrina, Horsfall, Leigh Ula, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine A., Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine, Clouston, Andrew D., Bernard, Anne and Powell, Elizabeth E. (2018). Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores. Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, San Francisco, CA United States, 9-13 November 2018. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/hep.30257
Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7
Patel, P. J., Smith, D. D., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N. N., Saad, N., Clouston, A. D., Irvine, K. M., Russell, A. W., Valery, P. C. and Powell, E. E. (2017). Can modest alcohol intake be dismissed as a co-factor in diabetic patients with non-alcoholic fatty liver disease?. International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Amsterdam, Netherlands, 19-23 April 2017. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(17)31602-1
Patel, P. J., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Saad, N., Clouston, A., Irvine, K. M., Russell, A., Valery, P. C. and Powell, E. E. (2017). Enhanced Liver Fibrosis test and liver stiffness measurements identify high prevalence of advanced fibrosis in people with type 2 diabetes. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20 - 22 August 2017. Richmond, VIC Australia: Wiley-Blackwell.
High-risk medication-related problems are prevalent in people with decompensated cirrhosis
Hayward, K. L., Patel, P. J., Valery, P. C., Horsfall, L. U., Li, C. Y., Wright, P. L., Tallis, C. J., Stuart, K. A., Irvine, K. M., Cottrell, W. N., Powell, E. E. and Martin, J. H. (2017). High-risk medication-related problems are prevalent in people with decompensated cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD, Australia, 20 - 22 August 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.
Medication beliefs predict low medication adherence in people with decompensated cirrhosis
Hayward, K. L., Valery, P. C., Martin, J. H., Karmakar, A., Patel, P. J., Horsfall, L. U., Irvine, K. M., Stuart, K. A., Tallis, C. J., Wright, P. L., Smith, D. D., Powell, E. E. and Cottrell, W. N. (2017). Medication beliefs predict low medication adherence in people with decompensated cirrhosis. International Liver Congress / 52nd Annual Meeting of the European Association for the Study of the Liver, Amsterdam, The Netherlands, 19 - 23 April 2017. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(17)31113-3
Medication adherence in outpatients with decompensated cirrhosis
Hayward, K. L., Cottrell, W. N., Karmakar, A., Patel, P. J., Horsfall, L. U., Martin, J. H., Irvine, K. M., Tallis, C. J., Wright, P. L., Stuart, K. A., Valery, P. C. and Powell, E. E. (2016). Medication adherence in outpatients with decompensated cirrhosis. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, SA Australia, 10–12 October 2016. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/jgh.13520
Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes
Patel, P. J., Stuart, K. A., Horsfall, L. U., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Clouston, A., Irvine, K. M., Russell, A. and Powell, E. E. (2016). Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October, 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13520
Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087
Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.
Discrepancies in the use of medications in patients with cirrhosis
Hayward, K., Valery, P. C., Cottrell, N., Irvine, K., Horsfall, L., Ruffin, B., Tallis, C., Chachay, V., Martin, J. and Powell, E. (2015). Discrepancies in the use of medications in patients with cirrhosis. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD Australia, 28 September - 2 October 2015. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/jgh.13093
Mcphail, S. M., Horsfall, L., Irvine, K., Fagan, K. J. and Powell, E. E. (2015). Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093
Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease
El-Atem, N., Wojcik, K., Horsfall, L., Irvine, K., Johnson, T., Mcphail, S. M. and Powell, E. E. (2015). Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093
Irvine, Katharine, Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin, Horsfall, Leigh, Fletcher, Linda, Ungerer, Jacobus, Pretorius, Carel J., Miller, Gregory, Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, United States, 13-17 November 2015. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/hep.28218
Irvine, K. M., Wockner, L. F., Shanker, M., Fagan, K. J., Horsfall, L. U., Fletcher, L. M., Ungerer, J., Pretorius, C. J., Miller, G. C., Clouston, A. D., Lampe, G. and Powell, E. E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093
Fagan, K., Horsfall, L., Irvine, K., Fletcher, L., Tate, J., Choi, K., Nusrat, S., Melino, M., Clouston, A., Ballard, E., O'Rourke, P., Lampe, G., Ungerer, J. and Powell, E. (2014). An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease. Australian Gastroenterology Week 2014, UnknownGold Coast Convention & Exhibition Centre, Broadbeach, Queensland, 22-24 October. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
Fagan, K. J., Melino, M., Powell, E. E. and Irvine, K. M. (2014). Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_5
Melino, M., Gadd, V., Martinez, M., Lineburg, K., Irvine, K., Clouston, A. D., Powell, E. E. and Macdonald, K. P. (2014). Spaciotemporal characterization of the cellular and molecular contributors to chronic hepatic fibrosis in a hepatotoxin-induced mouse model. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736
The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease
Gadd, Victoria L., Skoien, Richard, Fagan, Kevin, Irvine, Katharine, Powell, Elizabeth E. and Clouston, Andrew D. (2013). The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases, Washington Dc, Nov 01-05, 2013. HOBOKEN: WILEY-BLACKWELL.
Fagan, K., Irvine, K., Kumar, S., Bates, A., Horsfall, L., Feeney, G. and Powell, E. (2013). Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5
Fagan, K., Irvine, K., McWhinney, B., Fletcher, L., Horsfall, L., Johnson, L., Clouston, A., Jonsson, J., O'Rourke, P., Martin, J., Pretorius, C., Ungerer, J. and Powell, E. (2013). BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin. International Liver Congress / 48th Annual Meeting of the European Association for the Study of the Liver (EASL), Amsterdam, Netherlands, 24-28 April 2013. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(13)60527-9
Factors associated with mortality and unplanned hospital readmissions in patients with ascites
Zhao, E., Horsfall, L., Ruffin, B. J., Fagan, K. J., Irvine, K. M. and Powell, E. E. (2013). Factors associated with mortality and unplanned hospital readmissions in patients with ascites. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5
The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease
Gadd, V., Skoien, R., Fagan, K., Irvine, K., Powell, E. and Clouston, A. (2013). The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease. Australian Gastroenterology Week 2013, Melbourne Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Sweet, M. J., Schroder, K., Irvine, K. M., Taylor, M., Bokil, N. J., Broomfield, S., Schembri, M. A., Stacey, K. J. and Hume, D. A. (2012). Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse. European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Oxford, United Kingdom: Wiley-Blackwell. doi: 10.1111/imm.12002
The identification of novel CSF-1 target genes in human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, Oct 12-16, 2008. LONDON: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2008.07.078
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. BASEL: BIRKHAUSER VERLAG AG.
PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages
Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. BASEL: BIRKHAUSER VERLAG AG.
Katharine Irvine (2024). Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.. The University of Queensland. (Dataset) doi: 10.48610/ef2c29e
CSF1R_FRed_SupplementaryVideos
Irvine, Katharine, Hume, David and Sehgal, Anuj (2020). CSF1R_FRed_SupplementaryVideos. The University of Queensland. (Dataset) doi: 10.14264/8c6d4ba
The expression and function of G3BPs in macrophages
Irvine, Katharine Margaret. (2004). The expression and function of G3BPs in macrophages. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/272818
A macrophage-centric holistic view of postnatal development
(2024–2026) ARC Discovery Projects
Macrophage-driven lipid metabolism in health and disease - mechanisms and therapeutic opportunities
(2022–2024) NHMRC IDEAS Grants
Macrophage control of mammalian growth and development
(2021–2024) ARC Discovery Projects
CD14 inhibition in a Liver Inflammation mouse model
(2020–2021) Innovation Connections
CSF1 Therapy for Chronic Liver Disease
(2019–2022) NHMRC Project Grant
(2019–2021) Mater Foundation
Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
(2015–2017) Siemens Ltd
(2015–2016) PA Research Foundation
Human liver progenitor cell characterisation, isolation and manipulation
(2014) UWA-UQ Bilateral Research Collaboration Award
Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
(2013–2015) NHMRC Project Grant
ALF Pauline Hall Research Fellowship: The role of macrophage in chronic liver disease progression
(2012–2015) Australian Liver Foundation
Pathological changes associated with chronic RelB activiation in T1D
(2010–2012) Juvenile Diabetes Research Foundation
Human macrophage transcriptional network
(2005–2008) Riken Genomic Sciences Center
Functions of CSF1R signalling in inflammation.
Doctor Philosophy — Principal Advisor
Other advisors:
Investigation of Matrix Regulation of Wound Repair
Doctor Philosophy — Associate Advisor
Other advisors:
Deconvoluting Tissue Resident Macrophage Biology
Doctor Philosophy — Associate Advisor
Other advisors:
Macrophage colony stimulating factor in the treatment of non-alcoholic fatty liver disease
Doctor Philosophy — Associate Advisor
Other advisors:
Erythroid iron metabolism and its effect on systemic iron homeostasis
Doctor Philosophy — Associate Advisor
Other advisors:
The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions
Doctor Philosophy — Associate Advisor
Regulation and function of CSF1R-dependent tissue macrophage populations.
Doctor Philosophy — Associate Advisor
Other advisors:
Transcriptional regulation of the mouse Csf1r locus
Doctor Philosophy — Associate Advisor
Other advisors:
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
(2022) Master Philosophy — Principal Advisor
Other advisors:
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
The role of macrophages in the regulation of systemic metabolism
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
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(2015) Doctor Philosophy — Associate Advisor
Other advisors:
Cytokines and STAT3 signalling in autoimmune diseases
(2015) Doctor Philosophy — Associate Advisor
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Regulation of TLR4 signalling in macrophages by histone deacetylases
(2013) Doctor Philosophy — Associate Advisor
Other advisors: