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Professor Ranjeny Thomas

Arthritis Qld Chair of Rheumatology

The University of Queensland Diamantina Institute
Faculty of Medicine
ranjeny.thomas@uq.edu.au
+61 7 344 36960

Overview

Professor Thomas’ research is focused on the study of the biology and clinical use of human dendritic cells in autoimmune disease. It has explored basic mechanisms of immunity and dendritic cell function in autoimmune disease.

Professor Thomas is a graduate of the University of Western Australia. She received her MBBS in 1984, and then trained in Perth as a rheumatologist. She commenced a research fellowship with Peter Lipsky at Southwestern Medical Center, University of Texas in 1990, where she first identified and characterised human circulating dendritic cell precursors. She is now Professor of Rheumatology at University of Queensland Diamantina Institute, Translational Research Institute, consultant Rheumatologist at Princess Alexandra Hospital and fellow of the Australian Academy of Health and Medical Sciences.

Her research is focussed on the study of autoimmune disease and restoration of tolerance. Through this work, she developed and tested the first rheumatoid arthritis vaccine. She has also contributed major insights into the pathogenesis of spondyloarthropathy and autoimmune diabetes, leading to the development of disease biomarkers and innovative immunotherapies. Ranjeny is a director of the spin-off company, Dendright, which is developing antigen-specific (personalised) immunotherapy and companion biomarkers to prevent and treat rheumatoid arthritis. She is funded by the Juvenile Diabetes Research Foundation to develop antigen-specific immunotherapy for children with type 1 diabetes.

Research Impacts

1. My team and I developed and have a granted patent for a liposome immunotherapy strategy to induce antigen-specific tolerance in rheumatoid arthritis (RA). It is the first to specifically target ACPA autoantibody-positive patients carrying RA-susceptibility gene variants, each identifiable with existing tests. The product, DEN181 was developed by Dendright, the Uniquest spin-off company founded to commercialize the liposome technology, in partnership and option to licence with Janssen-Biotech, the US pharmaceutical subsidiary of Johnson and Johnson, for the indication of RA. DEN-181 commenced early-phase clinical trials in RA at PA Hospital in November 2017 (PI – Phillip Vecchio).

2. To translate antigen-specific immunotherapy to children with type 1 diabetes, we carried out pre-clinical studies with Emma Hamilton-Williams and Mark Harris. I am PI on a grant to this team from JDRF and the US Leona M. and Harry B. Helmsley Charitable Trust for a clinical trial of liposomes encapsulating NF-kB inhibitor and diabetes-specific peptide in patients with T1D. We are currently undertaking pre-clinical development.

3. Ahmed Mehdi in my team discovered a peripheral blood genomic signature predicting, in the first year of life, children at risk of future T1D (Mehdi et al, JCI Insight, 2018). Thus we have found a way to screen infant blood for risk of developing islet autoantibodies. With implementation of a screening test based on our findings, future monitoring programs could then focus on the small proportion of children at greatest risk. The gene “signature” provides a clear comparison of the overall differences between gene expression in white blood cells of children who progress to antibody development and children who don’t. This information offers insight into early, critical, developmental processes that are dysregulated in type 1 diabetes. The contribution of environmental factors to expression or suppression of the blood signature could now be tested in studies of at-risk children that are going on around the world, to inform future primary prevention studies.

4. My team developed a nanoparticle immunotherapy that targets tumor antigen to a specific dendritic cell subset that expresses CLEC9A with collaborators at Diamantina Institute (Riccardo Dolcetti, Roberta Mazzieri), AIBN (Anton Middelberg) and Monash University (Mireille Lahoud, Irine Caminschi). This technology stimulates therapeutically-effective tumor-specific immunity in several mouse models (Zeng et al, JCI 2018). We commenced a collaborative partnership in 2017 with Merck & Co to develop technologies for human cancer immunotherapy.

5. With Hani El-Ganalawy in Canada and Hugh Reid and Jamie Rossjohn at Monash University, we investigated how immune system cells become particularly cross-reactive in Indigenous North Americans, who have 3-5 times the risk of RA compared to Europeans. We found specific HLA genes were responsible for higher risk RA in Indigenous North Americans. HLA genes are used by the body to educate a person’s immune system to control infection, but in people with Rheumatoid Arthritis the process becomes confused, leading to an attack on the body’s tissues. Infection-fighting immune cells become more likely to cross-react with tissue cells as people age. Immune cells responding to HLA genes in North Indigenous Americans were particularly cross-reactive, resulting in RA being more prevalent and with earlier onset (Law et al, Ann Rheum Dis 2017). Understanding the genes and how they contribute to the cause of RA in the Indigenous North American population implies that specific immunotherapies could be designed for this population in the future.

Qualifications

  • MD, The University of Western Australia
  • FRACP
  • MBBS, The University of Western Australia

Publications

  • Journal Article: Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

    Zeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 5: 1971-1984. doi:10.1172/JCI96791

  • Journal Article: A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes

    Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018) A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 5: . doi:10.1172/jci.insight.98212

  • Journal Article: Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis

    Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017) Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 11: 1915-1923. doi:10.1136/annrheumdis-2017-211300

  • Journal Article: Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

    Benham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015) Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 290: 290ra87.1-290ra87.11. doi:10.1126/scitranslmed.aaa9301

  • Journal Article: High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice

    Baillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015) High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 6: 1535-1547. doi:10.1002/art.39041

  • Journal Article: ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice

    Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014) ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 10: 2780-2792. doi:10.1002/art.38773

  • Journal Article: Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice

    Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014) Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767. doi:10.1002/art.38638

  • Journal Article: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

    Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 12: 2569-2582. doi:10.1084/jem.20131241

  • Journal Article: β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

    Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012) β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 7: 2211-2222. doi:10.1002/art.34423

  • Journal Article: Antigen-specific suppression of inflammatory arthritis using liposomes

    Capini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009) Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 6: 3556-3565. doi:10.4049/jimmunol.0802972

View all Publications

Grants

View all Grants

Supervision

  • The role of peripheral regulatory T cells in the predisposition to Spondyloarthritis

    Doctor Philosophy

  • Development of assays for T cell response to myeloperoxidase in MPO ANCA-associated vasculitis

    Master Philosophy

  • Immunogenic epitopes of the TSH receptor in Graves' disease

    Doctor Philosophy

View all Supervision

Publications

Featured Publications

  • Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

    Zeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 5: 1971-1984. doi:10.1172/JCI96791

  • A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes

    Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018) A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 5: . doi:10.1172/jci.insight.98212

  • Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis

    Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017) Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 11: 1915-1923. doi:10.1136/annrheumdis-2017-211300

  • Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

    Benham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015) Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 290: 290ra87.1-290ra87.11. doi:10.1126/scitranslmed.aaa9301

  • High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice

    Baillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015) High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 6: 1535-1547. doi:10.1002/art.39041

  • ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice

    Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014) ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 10: 2780-2792. doi:10.1002/art.38773

  • Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice

    Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014) Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767. doi:10.1002/art.38638

  • A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

    Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 12: 2569-2582. doi:10.1084/jem.20131241

  • β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

    Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012) β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 7: 2211-2222. doi:10.1002/art.34423

  • Antigen-specific suppression of inflammatory arthritis using liposomes

    Capini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009) Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 6: 3556-3565. doi:10.4049/jimmunol.0802972

Book Chapter

  • Pathogenesis of rheumatoid arthritis

    Thomas, Ranjeny and Cope, Andrew P. (2013). Pathogenesis of rheumatoid arthritis. In Richard A. Watts, Philip G. Conaghan, Christopher Denton, Helen Foster, John Isaacs and Ulf Müller-Ladner (Ed.), Oxford Textbook of Rheumatology 4th ed. (pp. 839-848) Oxford, United Kingdom: Oxford University Press. doi:10.1093/med/9780199642489.001.0001

  • Dendritic Cells

    Pai, Saparna and Thomas, Ranjeny (2009). Dendritic Cells. In Rheumatoid Arthritis (pp. 116-123) : Elsevier Inc.. doi:10.1016/B978-032305475-1.50021-5

  • Dendritic cells

    Lutzky, Viviana and Thomas, Ranjeny (2007). Dendritic cells. In Josef F. Smolen and Peter E. Lipsky (Ed.), Contemporary Targeted therapies in Rheumatology (pp. 63-78) UK: Informa Healthcare.

  • Identification and isolation of synovial dendritic cells

    Pettit, Allison R., Cavanagh, Lois, Boyce, Amanda, Padmanabha, Jagadish, Peng, Judy and Thomas, Ranjeny. (2007). Identification and isolation of synovial dendritic cells. In Andrew P. Cope (Ed.), Arthritis Research Methods and Protocols (pp. 165-181) Totowa, N.J., U.S.A.: Humana Press Inc.

  • Dendritic Cells

    Thomas, Ranjeny, Thompson, Angus G., Martin, Ela and O'Sullivan, Brendan. J. (2003). Dendritic Cells. In Josef S. Smolen and Peter E. Lipsky (Ed.), Targeted Therapies in Rheumatology First ed. (pp. 61-81) London, UK: Martin Duntiz.

  • Dendritic Cells and Autoimmunity

    Thomas, R. (2001). Dendritic Cells and Autoimmunity. In M.T. Lotze and A.W. Thomason (Ed.), Dendritic Cells 2nd ed. (pp. 459-471) United Kingdom: Academic Press.

  • Identification and isolation of synovial dendritic cells

    Pettit, A. R., Cavanagh, L. L. and Thomas, R. (2001). Identification and isolation of synovial dendritic cells. In S. P. Robinson and A. J. Stagg (Ed.), Dendritic Cell Protocols (pp. 175-187) Totowa USA: Humana Press.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • The role of peripheral regulatory T cells in the predisposition to Spondyloarthritis

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Development of assays for T cell response to myeloperoxidase in MPO ANCA-associated vasculitis

    Master Philosophy — Principal Advisor

    Other advisors:

  • Immunogenic epitopes of the TSH receptor in Graves' disease

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Identification of Children with Type 1 Diabetes Suitable for Antigen-specific Tolerising Immunotherapy: T-cell response to relevant pancreatic islet peptides

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Unique T cell receptors (TCR) in autoimmune disease: biomarkers and therapeutic targets

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Factors influencing beta-cell destruction in type 1 diabetes

    Doctor Philosophy — Principal Advisor

  • Harnessing the immunomodulatory effects of NKT cells for cancer immunotherapy using a Clec9a-targeted nanoemulsion delivery system

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Nanoparticle delivery systems for antigen-specific immunotherapy in type 1 diabetes

    Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

This staff member is a UQ Expert for media in the following fields:

Autoimmune disease, Dendritic cells, Immunology, Immunotherapy, Rheumatoid arthritis, Disease - autoimmune, Immunity, Cells - dentric, Arthritis - rheumatoid

They are happy to lend their expertise to your articles or broadcasts and share their research discoveries and insights with the community via media channels.

For additional assistance with story ideas, general advice and information or help with seeking further experts, please email the UQ Media Team or telephone (07) 3365 1120.

Links

ResearcherID: B-4504-2013

ORCID: 0000-0002-0518-8386

Scopus ID: 35430984400

Google Scholar ID:

Personal Profile: Link

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