Professor Thomas’ research is focused on the study of the biology and clinical use of human dendritic cells in autoimmune disease. It has explored basic mechanisms of immunity and dendritic cell function in autoimmune disease.
Professor Thomas is a graduate of the University of Western Australia. She received her MBBS in 1984, and then trained in Perth as a rheumatologist. She commenced a research fellowship with Peter Lipsky at Southwestern Medical Center, University of Texas in 1990, where she first identified and characterised human circulating dendritic cell precursors. She is now Professor of Rheumatology at University of Queensland Diamantina Institute, Translational Research Institute, consultant Rheumatologist at Princess Alexandra Hospital and fellow of the Australian Academy of Health and Medical Sciences.
Her research is focussed on the study of autoimmune disease and restoration of tolerance. Through this work, she developed and tested the first rheumatoid arthritis vaccine. She has also contributed major insights into the pathogenesis of spondyloarthropathy and autoimmune diabetes, leading to the development of disease biomarkers and innovative immunotherapies. Ranjeny is a director of the spin-off company, Dendright, which is developing antigen-specific (personalised) immunotherapy and companion biomarkers to prevent and treat rheumatoid arthritis. She is funded by the Juvenile Diabetes Research Foundation to develop antigen-specific immunotherapy for children with type 1 diabetes.
1. My team and I developed and have a granted patent for a liposome immunotherapy strategy to induce antigen-specific tolerance in rheumatoid arthritis (RA). It is the first to specifically target ACPA autoantibody-positive patients carrying RA-susceptibility gene variants, each identifiable with existing tests. The product, DEN181 was developed by Dendright, the Uniquest spin-off company founded to commercialize the liposome technology, in partnership and option to licence with Janssen-Biotech, the US pharmaceutical subsidiary of Johnson and Johnson, for the indication of RA. DEN-181 commenced early-phase clinical trials in RA at PA Hospital in November 2017 (PI – Phillip Vecchio).
2. To translate antigen-specific immunotherapy to children with type 1 diabetes, we carried out pre-clinical studies with Emma Hamilton-Williams and Mark Harris. I am PI on a grant to this team from JDRF and the US Leona M. and Harry B. Helmsley Charitable Trust for a clinical trial of liposomes encapsulating NF-kB inhibitor and diabetes-specific peptide in patients with T1D. We are currently undertaking pre-clinical development.
3. Ahmed Mehdi in my team discovered a peripheral blood genomic signature predicting, in the first year of life, children at risk of future T1D (Mehdi et al, JCI Insight, 2018). Thus we have found a way to screen infant blood for risk of developing islet autoantibodies. With implementation of a screening test based on our findings, future monitoring programs could then focus on the small proportion of children at greatest risk. The gene “signature” provides a clear comparison of the overall differences between gene expression in white blood cells of children who progress to antibody development and children who don’t. This information offers insight into early, critical, developmental processes that are dysregulated in type 1 diabetes. The contribution of environmental factors to expression or suppression of the blood signature could now be tested in studies of at-risk children that are going on around the world, to inform future primary prevention studies.
4. My team developed a nanoparticle immunotherapy that targets tumor antigen to a specific dendritic cell subset that expresses CLEC9A with collaborators at Diamantina Institute (Riccardo Dolcetti, Roberta Mazzieri), AIBN (Anton Middelberg) and Monash University (Mireille Lahoud, Irine Caminschi). This technology stimulates therapeutically-effective tumor-specific immunity in several mouse models (Zeng et al, JCI 2018). We commenced a collaborative partnership in 2017 with Merck & Co to develop technologies for human cancer immunotherapy.
5. With Hani El-Ganalawy in Canada and Hugh Reid and Jamie Rossjohn at Monash University, we investigated how immune system cells become particularly cross-reactive in Indigenous North Americans, who have 3-5 times the risk of RA compared to Europeans. We found specific HLA genes were responsible for higher risk RA in Indigenous North Americans. HLA genes are used by the body to educate a person’s immune system to control infection, but in people with Rheumatoid Arthritis the process becomes confused, leading to an attack on the body’s tissues. Infection-fighting immune cells become more likely to cross-react with tissue cells as people age. Immune cells responding to HLA genes in North Indigenous Americans were particularly cross-reactive, resulting in RA being more prevalent and with earlier onset (Law et al, Ann Rheum Dis 2017). Understanding the genes and how they contribute to the cause of RA in the Indigenous North American population implies that specific immunotherapies could be designed for this population in the future.
Journal Article: Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy
Zeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 5: 1971-1984. doi:10.1172/JCI96791
Journal Article: A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes
Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018) A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 5: . doi:10.1172/jci.insight.98212
Journal Article: Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis
Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017) Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 11: 1915-1923. doi:10.1136/annrheumdis-2017-211300
Journal Article: Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients
Benham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015) Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 290: 290ra87.1-290ra87.11. doi:10.1126/scitranslmed.aaa9301
Journal Article: High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice
Baillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015) High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 6: 1535-1547. doi:10.1002/art.39041
Journal Article: ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014) ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 10: 2780-2792. doi:10.1002/art.38773
Journal Article: Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014) Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767. doi:10.1002/art.38638
Journal Article: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 12: 2569-2582. doi:10.1084/jem.20131241
Journal Article: β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012) β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 7: 2211-2222. doi:10.1002/art.34423
Journal Article: Antigen-specific suppression of inflammatory arthritis using liposomes
Capini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009) Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 6: 3556-3565. doi:10.4049/jimmunol.0802972
Australian Arthritis and Autoimmune Biobank Collaborative (A3BC)
(2019–2022) University of Sydney
New strategies for targeting immune evasion in children's brain tumours
(2019–2021) The Children's Hospital Foundation
Development of antigen-specific immunotherapy for Wegener's granulomatosis
(2018–2023) Research Donation Generic
The role of peripheral regulatory T cells in the predisposition to Spondyloarthritis
Doctor Philosophy
Development of assays for T cell response to myeloperoxidase in MPO ANCA-associated vasculitis
Master Philosophy
Immunogenic epitopes of the TSH receptor in Graves' disease
Doctor Philosophy
Zeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 5: 1971-1984. doi:10.1172/JCI96791
Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018) A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 5: . doi:10.1172/jci.insight.98212
Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017) Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 11: 1915-1923. doi:10.1136/annrheumdis-2017-211300
Benham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015) Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 290: 290ra87.1-290ra87.11. doi:10.1126/scitranslmed.aaa9301
High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice
Baillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015) High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 6: 1535-1547. doi:10.1002/art.39041
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014) ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 10: 2780-2792. doi:10.1002/art.38773
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014) Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767. doi:10.1002/art.38638
Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 12: 2569-2582. doi:10.1084/jem.20131241
β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012) β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 7: 2211-2222. doi:10.1002/art.34423
Antigen-specific suppression of inflammatory arthritis using liposomes
Capini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009) Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 6: 3556-3565. doi:10.4049/jimmunol.0802972
Pathogenesis of rheumatoid arthritis
Thomas, Ranjeny and Cope, Andrew P. (2013). Pathogenesis of rheumatoid arthritis. In Richard A. Watts, Philip G. Conaghan, Christopher Denton, Helen Foster, John Isaacs and Ulf Müller-Ladner (Ed.), Oxford Textbook of Rheumatology 4th ed. (pp. 839-848) Oxford, United Kingdom: Oxford University Press. doi:10.1093/med/9780199642489.001.0001
Pai, Saparna and Thomas, Ranjeny (2009). Dendritic Cells. In Rheumatoid Arthritis (pp. 116-123) : Elsevier Inc.. doi:10.1016/B978-032305475-1.50021-5
Lutzky, Viviana and Thomas, Ranjeny (2007). Dendritic cells. In Josef F. Smolen and Peter E. Lipsky (Ed.), Contemporary Targeted therapies in Rheumatology (pp. 63-78) UK: Informa Healthcare.
Identification and isolation of synovial dendritic cells
Pettit, Allison R., Cavanagh, Lois, Boyce, Amanda, Padmanabha, Jagadish, Peng, Judy and Thomas, Ranjeny. (2007). Identification and isolation of synovial dendritic cells. In Andrew P. Cope (Ed.), Arthritis Research Methods and Protocols (pp. 165-181) Totowa, N.J., U.S.A.: Humana Press Inc.
Thomas, Ranjeny, Thompson, Angus G., Martin, Ela and O'Sullivan, Brendan. J. (2003). Dendritic Cells. In Josef S. Smolen and Peter E. Lipsky (Ed.), Targeted Therapies in Rheumatology First ed. (pp. 61-81) London, UK: Martin Duntiz.
Dendritic Cells and Autoimmunity
Thomas, R. (2001). Dendritic Cells and Autoimmunity. In M.T. Lotze and A.W. Thomason (Ed.), Dendritic Cells 2nd ed. (pp. 459-471) United Kingdom: Academic Press.
Identification and isolation of synovial dendritic cells
Pettit, A. R., Cavanagh, L. L. and Thomas, R. (2001). Identification and isolation of synovial dendritic cells. In S. P. Robinson and A. J. Stagg (Ed.), Dendritic Cell Protocols (pp. 175-187) Totowa USA: Humana Press.
Galea, Ryan, Nel, Hendrik, Talekar, Meghna, Liu, Xiao, Ooi, Joshua D., Huynh, Megan, Hadjigol, Sara, Robson, Kate J., Ting, Yi Tian, Cole, Suzanne, Cochlin, Karyn, Hitchcock, Shannon, Zeng, Bijun, Yekollu, Suman, Boks, Martine, Goh, Natalie, Roberts, Helen, Rossjohn, Jamie, Reid, Hugh H., Boyd, Ben J., Malaviya, Ravi, Shealy, David J., Baker, Daniel G., Madakamutil, Loui, Kitching, A. Richard, O’Sullivan, Brendan J. and Thomas, Ranjeny (2019) PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease. JCI Insight, 4 18: . doi:10.1172/jci.insight.126025
Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019) MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 5: 885-898.e7. doi:10.1016/j.immuni.2019.08.011
Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC
Garcia-Gonzalez, Paulina A., Maggi, Jaxaira, Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Soto, Lilian, Neire, Oscar, Mehdi, Ahmed M., Nel, Hendrik J., Pesce, Barbara, Aravena, Octavio, Carmen Molina, Maria, Catalan, Diego, Thomas, Ranjeny, Verdugo, Ricardo A. and Carlos Aguillon, Juan (2019) Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC. Frontiers in Immunology, 10 1171. doi:10.3389/fimmu.2019.01171
NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion
Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019) NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 6: 952-962. doi:10.1158/2326-6066.cir-18-0650
A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells
Dey, Shuvashis, Vaidyanathan, Ramanathan, Reza, K. Kamil, Wang, Jing, Wang, Yuling, Nel, Hendrik J., Law, Soi-Cheng, Tyler, Jennifer, Rossjohn, Jamie, Reid, Hugh H., Ibn Sina, Abu Ali, Thomas, Ranjeny and Trau, Matt (2019) A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells. Sensors and Actuators B: Chemical, 284 281-288. doi:10.1016/j.snb.2018.12.099
Schinnerling, Katina, Rosas, Carlos, Soto, Lilian, Thomas, Ranjeny and Carlos Aguillon, Juan (2019) Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies. Frontiers in Immunology, 10 203. doi:10.3389/fimmu.2019.00203
Liff, Marthe Halsan, Hoff, Mari, Fremo, Thomas, Wisløff, Ulrik, Thomas, Ranjeny and Videm, Vibeke (2019) Cardiorespiratory fitness in patients with rheumatoid arthritis is associated with the patient global assessment but not with objective measurements of disease activity. RMD Open, 5 1: . doi:10.1136/rmdopen-2019-000912
Rehaume, Linda M., Matigian, Nicholas, Mehdi, Ahmed M., Lachner, Nancy, Bowerman, Kate L., Daly, Joshua, Lê Cao, Kim-Anh, Hugenholtz, Philip and Thomas, Ranjeny (2019) IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. Annals of the Rheumatic Diseases, 78 4: 494-503. doi:10.1136/annrheumdis-2018-214381
Koppejan, Hester, Jansen, Diahann T. S. L., Hameetman, Marjolijn, Thomas, Ranjeny, Toes, Rene E. M. and van Gaalen, Floris A. (2019) Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis. Arthritis Research and Therapy, 21 1: . doi:10.1186/s13075-018-1799-1
Buchanan, Kerry, Mehdi, Ahmed M, Hughes, Ian, Cotterill, Andrew, Le Cao, Kim-Anh, Thomas, Ranjeny and Harris, Mark (2018) An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes. Pediatric Diabetes, . doi:10.1111/pedi.12808
Wehr, P., Purvis, H., Law, S.-C. and Thomas, R. (2018) Dendritic cells, T cells and their interaction in rheumatoid arthritis : Dendritic cells, T cells and their interaction. Clinical and Experimental Immunology, . doi:10.1111/cei.13256
The SKG model of spondyloarthritis
Rahman, M. Arifur and Thomas, Ranjeny (2018) The SKG model of spondyloarthritis. Best Practice and Research: Clinical Rheumatology, 30 1-15. doi:10.1016/j.berh.2018.07.004
Ciccia, Francesco, Guggino, Giuliana, Zeng, Michael, Thomas, Ranjeny, Ranganathan, Vidya, Rahman, Arifur, Alessandro, Riccardo, Rizzo, Aroldo, Saieva, Laura, Macaluso, Federica, Peralta, Sergio, Di Liberto, Diana, Dieli, Francesco, Cipriani, Paola, Giacomelli, Roberto, Baeten, Dominique and Haroon, Nigil (2018) Pro-inflammatory CX3CR1 CD59 TL1A IL-23 monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions. Arthritis & Rheumatology, . doi:10.1002/art.40582
Ison, Matthew, Duggan, Emily, Mehdi, Ahmed, Thomas, Ranjeny and Benham, Helen (2018) Treatment delays for patients with new onset rheumatoid arthritis presenting to an Australian early arthritis clinic. Internal Medicine Journal, . doi:10.1111/imj.13972
Autoimmune-mediated thymic atrophy is accelerated but reversible in RelB-deficient mice
O'Sullivan, Brendan J., Yekollu, Suman, Ruscher, Roland, Mehdi, Ahmed M., Maradana, Muralidhara Rao, Chidgey, Ann P. and Thomas, Ranjeny (2018) Autoimmune-mediated thymic atrophy is accelerated but reversible in RelB-deficient mice. Frontiers in Immunology, 9 MAY: 1092. doi:10.3389/fimmu.2018.01092
Zeng, Bijun, Middelberg, Anton P. J., Gemiarto, Adrian, MacDonald, Kelli, Baxter, Alan G, Talekar, Meghna, Moi, Davide, Tullett, Kirsteen M, Caminschi, Irina, Lahoud, Mireille H, Mazzieri, Roberta, Dolcetti, Riccardo and Thomas, Ranjeny (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. The Journal of clinical investigation, 128 5: 1971-1984. doi:10.1172/JCI96791
Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018) A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 5: . doi:10.1172/jci.insight.98212
Jansen, Diahann T. S. L., Ramnoruth, Nishta, Loh, Khai L., Rossjohn, Jamie, Reid, Hugh H., Nel, Hendrik J. and Thomas, Ranjeny (2018) Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol Development. Frontiers in Immunology, 9 JAN: 1-10. doi:10.3389/fimmu.2018.00008
Ting, Yi Tian, Petersen, Jan, Ramarathinam, Sri H., Scally, Stephen W., Loh, Khai L., Thomas, Ranjeny, Suri, Anish, Baker, Daniel G., Purcell, Anthony W., Reid, Hugh H. and Rossjohn, Jamie (2018) The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis. The Journal of Biological Chemistry, 293 9: 3236-3251. doi:10.1074/jbc.RA117.001013
Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018) Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78 80-94. doi:10.1016/j.metabol.2017.09.002
Eley, Diann S., Jensen, Charmaine, Thomas, Ranjeny and Benham, Helen (2017) What will it take? Pathways, time and funding: Australian medical students' perspective on clinician-scientist training. BMC Medical Education, 14 242: 242. doi:10.1186/s12909-017-1081-2
Garcia-Gonzalez, Paulina A., Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Maggi, Jaxaira, Mehdi, Ahmed M., Nel, Hendrik J., Pesce, Barbara, Larrondo, Milton L., Aravena, Octavio, Molina, Mar-A C., Catalan, Diego, Thomas, Ranjeny, Verdugo, Ricardo A. and Aguillon, Juan C. (2017) Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells through transcriptional modulation of genes associated with essential processes of the immune response. Frontiers in Immunology, 8 OCT: 1350. doi:10.3389/fimmu.2017.01350
Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen Van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E., Moustakas, Antonis K, Papadopoulos, George K, Woude, Diane Van Der, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani and Thomas, Ranjeny (2017) Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Annals of the Rheumatic Diseases, 76 11: 1915-1923. doi:10.1136/annrheumdis-2017-211300
RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation
Nair, Prema M, Starkey, Malcolm R, Haw, Tatt Jhong, Ruscher, Roland, Liu, Gang, Maradana, Muralidhara R, Thomas, Ranjeny, O'Sullivan, Brendan J and Hansbro, Philip M (2017) RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation. American Journal of Respiratory Cell and Molecular Biology, 58 3: 352-365. doi:10.1165/rcmb.2017-0242OC
Gatica-Andrades, Marcela, Vagenas, Dimitrios, Kling, Jessica, Nguyen, Tam T. K., Benham, Helen, Thomas, Ranjeny, Korner, Heinrich, Venkatesh, Bala, Cohen, Jeremy and Blumenthal, Antje (2017) WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice. Blood Advances, 1 16: 1274-1286. doi:10.1182/bloodadvances.2017006163
Videm, Vibeke, Thomas, Ranjeny, Brown, Matthew A. and Hoff, Mari (2017) Self-reported diagnosis of rheumatoid arthritis or ankylosing spondylitis has low accuracy – data from the Nord-Trøndelag Health Study. Journal of Rheumatology, 44 8: 1134-1141. doi:10.3899/jrheum.161396
Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells
Zhang, Ping, Lee, Jason S., Gartlan, Kate H., Schuster, Iona S., Comerford, Iain, Varelias, Antiopi, Ullah, Md Ashik, Vuckovic, Slavica, Koyama, Motoko, Kuns, Rachel D., Locke, Kelly R., Beckett, Kirrilee J., Olver, Stuart D., Samson, Luke D., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Clouston, Andrew D., Belz, Gabrielle T., Blazar, Bruce R., MacDonald, Kelli P., McColl, Shaun R., Thomas, Ranjeny, Engwerda, Christian R., Degli-Esposti, Mariapia A., Kallies, Axel, Tey, Siok-Keen and Hill, Geoffrey R. (2017) Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells. Science Immunology, 2 10: eaah7152. doi:10.1126/sciimmunol.aah7152
Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey
Ramos-Remus, Cesar, Barajas-Ochoa, Aldo, Ramirez-Gomez, Andrea, Castillo-Ortiz, Jose D., Brambila-Barba, Victor, Adebajo, Adewale O., Espinoza, Luis R., Aceves-Avila, Francisco J., Sanchez-Gonzalez, Jorge M., Boudersa, Nadia, Slimani, Samy, Ladjouze-Rezig, Aicha, Diaz, Monica P., Kirmayr, Karin I., Asnal, Cecilia A., Catoggio, Luis J., Citera, Gustavo, Casado, Gustavo C., Alvarez, Analia P., Pisoni, Cecilia N., Benavente, Emilio, Lopez-Cabanillas, Adriana, Baez, Roberto M., Pons-Estel, Bernardo A., Sacnun, Monica P., Cavallasca, Javier A., Paniego, Raul H., Proudman, Susanna M., Thomas, Ranjeny, Major, Gabor, Mathers, David M., Schrieber, Leslie, Islam, Nazrul, Haq, Syed A., Dessein, Patrick H., von Muhlen, Carlos A., Bianchi, Washington A., Castelar-Pinheiro, Geraldo da R., Feldman-Pollak, Daniel, Cossermelli, Waldenise, Bonfiglioli, Karina R., Giorgi, Rina D., Zabsonre-Tiendrebeogo, Wendlassida J., Olaru, Lilia, Karsh, Jacob, Castro-Esparza, Irene H., Fuentealba, Carlos, Aguilera, Sergio, Burgos, Paula I., Neira, Oscar, Li, Zhan-guo, Tam, Lai-Shan, Mok, Mo Y., Medina, Yimy F., Zuniga-Vera, Andres E., Moreno-Alvarez, Mario J., Vera, Claudia, Quezada, Ivonne, Moreno, Ivan M., Calapaqui, Wendy, El-Mardenly, Ghada, Salama, M. Salah, Ragab, Gaafar, Gado, Kamel, Hadidi, Tahsin, Leirisalo-Repo, Marjatta, Tuompo, Riitta, Koivuniemi, Riitta, Berenbaum, Francis, Allanore, Yannick, Constantin, Arnaud, Buttgereit, Frank, Schulze-Koops, Hendrik, Liz, Myriam, Dey, Dzifa, Santiago-Pastelin, Carlos B., Alonzo-Borjas, Hugo D., Cuellar-Cruz, Victor, Dharmanand, Balebail G., Yathish, G. C., Akerkar, Shashank M., Malaviya, Anand N., Ahmadzadeh, Arman, Hasunuma, Tomoko, Owino, Benard O., Pacheco-Tena, Cesar, Frausto-Arenas, Aaron, De la Madrid-Cernas, Adrian A., Cardona-Cabrera, Roman, Centeno-Valadez, Juan D., Rodriguez-Torres, Isaura M., Vaidya, Binit, Gupta, Arun K., Harrison, Andrew A., Grainger, Rebecca, Nwankwo, Henry M., Diamantopoulos, Andreas P., Maeland, Elisabeth, Besada, Emilio, Gorriz, Luis, Duarte, Margarita, Cabrera-Villalba, Sonia, Albrecht, Maria T. Romero-de, Garcia-Poma, Augusto, Segami, Maria I., Ramos, Maria P., Perez-Medina, Wilkerson, Dianongco, Maria L., Lichauco, Juan J., Racaza, Geraldine Z., Navarra, Sandra V., Torralba, Tito P., Manapat-Reyes, Bernadette H., Penserga, Ester G., Hammoudeh, Mohammed, Al-Emadi, Samar, Botchkova, Anna G., AlSaeedi, Sabri H., Almoallim, Hani, Al-Arfaj, Hussein F., Koh, Wei H., Leung, Ying Y., Whitelaw, David A., Hodkinson, Bridget, Garcia-Miguel, Javier, Duro, Juan C., Martin-Mola, Emilio, Ahijon-Lana, Maria, Andreu, Jose L., Finckh, Axel, Alpizar-Rodriguez, Deshire, Osiri, Manathip, Kasitanon, Nuntana, Louthrenoo, Worawit, van Vollenhoven, Ronald F., de Vries, Niek, van Denderen, Christiaan, Gerritsen, Martjin, Jansen, Tim L., van Riel, Piet, Nunez-Sotelo, Concepcion M. and Villegas-Morales, Sol (2017) Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey. Clinical Rheumatology, 36 3: 485-497. doi:10.1007/s10067-016-3481-9
Lau, Max C., Keith, Patricia, Costello, Mary-Ellen, Bradbury, Linda A., Hollis, Kelly A., Thomas, Ranjeny, Thomas, Gethin P., Brown, Matthew A. and Kenna, Tony J. (2017) Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Annals of the Rheumatic Diseases, 76 1: 261-269. doi:10.1136/annrheumdis-2015-208677
Garcia-Gonzalez, Paulina A., Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Barbara, Carmen Molina, Maria, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Oscar, Francisco Catalan, Diego, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A. and Aguillon, Juan C. (2016) Treatment with dexamethasone and monophosphoryl lipid a removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid arthritis patients and confers tolerogenic features. Frontiers in Immunology, 7 OCT: 458. doi:10.3389/fimmu.2016.00458
Coleman, Miranda A., Jessup, Claire F., Bridge, Jennifer A., Overgaard, Nana H., Penko, Daniella, Walters, Stacey, Borg, Danielle J., Galea, Ryan, Forbes, Josephine M., Thomas, Ranjeny, Coates, Patrick T. C., Grey, Shane T., Wells, James W. and Steptoe, Raymond J. (2016) Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65 5: 1328-1340. doi:10.2337/db15-1418
Mutalik, Srinivas, Suthar, Neelam A., Managuli, Renuka S., Shetty, Pallavi K., Avadhani, Kiran, Kalthur, Guruprasad, Kulkarni, Raghavendra V. and Thomas, Ranjeny (2016) Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin. International Journal of Biological Macromolecules, 86 709-720. doi:10.1016/j.ijbiomac.2015.11.092
James, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016) Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 5: 509-519. doi:10.1038/icb.2016.7
Cummins, L., Katikireddi, V. S., Shankaranarayana, S., Su, K. Y. C., Duggan, E., Videm, V., Pahau, H. and Thomas, R. (2015) Safety and retention of combination triple disease-modifying anti-rheumatic drugs in new-onset rheumatoid arthritis. Internal Medicine Journal, 45 12: 1266-1273. doi:10.1111/imj.12896
Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes
Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015) Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 8: e41.1-e41.9. doi:10.1038/cti.2015.17
Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens
Koning, Frits, Thomas, Ranjeny, Rossjohn, Jamie and Toes, Rene E. (2015) Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens. Nature Reviews Rheumatology, 11 8: 450-461. doi:10.1038/nrrheum.2015.59
Benham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015) Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 290: 290ra87.1-290ra87.11. doi:10.1126/scitranslmed.aaa9301
High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice
Baillet, Athan C., Rehaume, Linda, Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth W. and Thomas, Ranjeny (2015) High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. Arthritis and Rheumatology, 67 6: 1535-1547. doi:10.1002/art.39041
Anderson, Amy E., Pratt, Arthur G., Sedhom, Mamdouh A. K., Doran, John Paul, Routledge, Christine, Hargreaves, Ben, Brown, Philip M., Cao, Kim-Anh Le, Isaacs, John D. and Thomas, Ranjeny (2015) IL-6 driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis.. Annals of the Rheumatic Diseases, 75 2: 466-473. doi:10.1136/annrheumdis-2014-205850
Role of genetics in infection-associated arthritis
Benham, Helen, Robinson, Philip C., Baillet, Athan C., Rehaume, Linda M. and Thomas, Ranjeny (2015) Role of genetics in infection-associated arthritis. Best Practice and Research: Clinical Rheumatology, 29 2: 213-225. doi:10.1016/j.berh.2015.02.002
Videm, Vibeke, Cortes, Adrian, Thomas, Ranjeny and Brown, Matthew A. (2014) Current smoking is a risk factor for incident ankylosing spondylitis – HUNT population-based Norwegian health study.. Journal of Rheumatology, 41 10: 2041-2048. doi:10.3899/jrheum.140353
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014) ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 10: 2780-2792. doi:10.1002/art.38773
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014) Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767. doi:10.1002/art.38638
Pahau, Helen, Brown, Matthew A., Paul, Sanjoy, Thomas, Ranjeny and Videm, Vibeke (2014) Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trøndelag health study (HUNT). Arthritis Research and Therapy, 16 2: 1-9. doi:10.1186/ar4527
McNally, Alice, McNally, Michael, Galea, Ryan, Thomas, Ranjeny and Steptoe, Raymond J. (2014) Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+T-cell effector differentiation by IL-2 modulation. PloS One, 9 1: e85455. doi:10.1371/journal.pone.0085455
Dendritic cells as targets or therapeutics in rheumatic autoimmune disease
Thomas, Ranjeny (2014) Dendritic cells as targets or therapeutics in rheumatic autoimmune disease. Current Opinion in Rheumatology, 26 2: 211-218. doi:10.1097/BOR.0000000000000032
Law, Soi-Chen, Benham, Helen, Reid, Hugh H., Rossjohn, Jamie and Thomas, Ranjeny (2014) Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis. Rheumatic Disease Clinics of North America, 40 4: 735-752. doi:10.1016/j.rdc.2014.07.015
Zeng, B. J., Chuan, Y. P., O’Sullivan, B., Caminschi, I., Lahoud, M. H., Thomas, R. and Middelberg, A. P. J. (2013) Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly. Small, 9 22: 3736-3742. doi:10.1002/smll.201300078
Thomas, Ranjeny (2013) RelB, AhR and dendritic cells RelB and the aryl hydrocarbon receptor: dendritic cell tolerance at the epithelial interface. Immunology and Cell Biology, 91 9: 543-544. doi:10.1038/icb.2013.51
Th17 and Th22 cells in psoriatic arthritis and psoriasis
Benham, Helen, Norris, Paul, Goodall, Jane, Wechalekar, Mihir D., FitzGerald, Oliver, Szentpetery, Agnes, Smith, Malcolm, Thomas, Ranjeny and Gaston, Hill (2013) Th17 and Th22 cells in psoriatic arthritis and psoriasis. Arthritis Research and Therapy, 15 5: . doi:10.1186/ar4317
Coleman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013) Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 6: 1049-1058. doi:10.1182/blood-2012-06-434100
Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny and Rossjohn, Jamie (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Journal of Experimental Medicine, 210 12: 2569-2582. doi:10.1084/jem.20131241
Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis
Thomas, Ranjeny (2013) Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis. Arthritis Research & Therapy, 15 1: 204.1-204.10. doi:10.1186/ar4130
Synovial fluid CD1c(+) myeloid dendritic cells - the inflammatory picture emerges
Thomas, Ranjeny (2013) Synovial fluid CD1c(+) myeloid dendritic cells - the inflammatory picture emerges. Arthritis Research & Therapy, 15 6: . doi:10.1186/ar4420
Targeted delivery of curcumin for treating type 2 diabetes
Maradana, Muralidhara Rao, Thomas, Ranjeny and O'Sullivan, Brendan J. (2013) Targeted delivery of curcumin for treating type 2 diabetes. Molecular Nutrition and Food Research, 57 9: 1550-1556. doi:10.1002/mnfr.201200791
White, Douglas, Pahau, Helen, Duggan, Emily, Paul, Sanjoy and Thomas, Ranjeny (2013) Trajectory of intensive treat-to-target disease modifying drug regimen in an observational study of an early rheumatoid arthritis cohort. BMJ Open, 3 7: e003083.1-e003083.10. doi:10.1136/bmjopen-2013-003083
β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012) β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 7: 2211-2222. doi:10.1002/art.34423
Kenna, Tony J., Davidson, Stuart I., Duan, Ran, Bradbury, Linda A., McFarlane, Janelle, Smith, Malcolm, Weedon, Helen, Street, Shayna, Thomas, Ranjeny, Thomas, Gethin P. and Brown, Matthew A. (2012) Enrichment of circulating IL-17-secreting IL-23 receptor-positive gamma-delta T cells in patients with active ankylosing spondylitis. Arthritis and Rheumatism, 64 5: 1420-1429. doi:10.1002/art.33507
Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew and Thomas, Ranjeny (2012) Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes. Diabetes, 61 5: 1281-1290. doi:10.2337/db11-1549
Law, Soi Cheng, Street, Shayna, Yu, Chien-Hsiung Alan, Capini, Christelle, Ramnoruth, Sakoontalla, Nel, Hendrik J., van Gorp, Eline, Hyde, Claire, Lau, Kim, Pahau, Helen, Purcell, Anthony W. and Thomas, Ranjeny (2012) T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles. Arthritis Research and Therapy, 14 3: R118.1-R118.12. doi:10.1186/ar3848
Autoimmunity: innovation in pathogenesis and therapy
Thomas, Ranjeny (2012) Autoimmunity: innovation in pathogenesis and therapy. Immunology and Cell Biology, 90 3: 255-255. doi:10.1038/icb.2012.5
T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man
Sakaguchi, Shimon, Benham, Helen, Cope, Andrew P. and Thomas, Ranjeny (2012) T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunology and Cell Biology, 90 3: 277-287. doi:10.1038/icb.2012.4
Chuan, Yap Pang, Zeng, Bi Yun, O'Sullivan, Brendan, Thomas, Ranjeny and Middelberg, Anton P. J. (2012) Co-delivery of antigen and a lipophilic anti-inflammatory drug to cells via a tailorable nanocarrier emulsion. Journal of Colloid and Interface Science, 368 1: 616-624. doi:10.1016/j.jcis.2011.11.014
Langerhans cells are precommitted to immune tolerance induction
Shklovskaya, Elena, O'Sullivan, Brendan J., Ng, Lai Guan, Roediger, Ben, Thomas, Ranjeny, Weninger, Wolfgang and de St Groth, Barbara Fazekas (2011) Langerhans cells are precommitted to immune tolerance induction. Proceedings of the National Academy of Sciences of the United States of America, 108 44: 18049-18054. doi:10.1073/pnas.1110076108
Yekollu, Suman Kumar, Thomas, Ranjeny and O'Sullivan, Brendan (2011) Targeting curcusomes to inflammatory dendritic cells inhibits NF-{kappa}b and improves insulin resistance in obese mice. Diabetes, 60 11: 2928-2938. doi:10.2337/db11-0275
Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation
O'Sullivan, Brendan J., Pai, Saparna, Street, Shayna, An, Xiayou, Macdonald, Kelli P. A., Wong, Michelle, Strutton, Geoffrey, Gerondakis, Steve, Steptoe, Raymond J., Fazekas de St Groth, Barbara, Hill, Geoffrey R. and Thomas, Ranjeny (2011) Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. Journal of Immunology, 187 7: 4018-4030. doi:10.4049/jimmunol.1101727
McNally, Alice, Hill, Geoffrey R., Sparwasser, Tim, Thomas, Ranjeny and Steptoe, Raymond J. (2011) CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 108 18: 7529-7534. doi:10.1073/pnas.1103782108
Reduced soluble receptor for advanced glycation end-products in COPD
Smith, D. J., Yerkovich, S. T., Towers, M. A., Carroll, M. L., Thomas, R. and Upham, J. W. (2011) Reduced soluble receptor for advanced glycation end-products in COPD. European Respiratory Journal, 37 3: 516-522. doi:10.1183/09031936.00029310
Bertin-Maghit, Sebastien, Pang, Dimeng, O'Sullivan, Brendan, Best, Shannon, Duggan, Emily, Paul, Sanjoy, Thomas, Helen, Kay, Thomas W. H., Harrison, Leonard C., Steptoe, Raymond and Thomas, Ranjeny (2011) Interleukin-1 beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes, 60 1: 248-257. doi:10.2337/db10-0104
Preston, J. A., Thorburn, A. N., Starkey, M. R., Beckett, E. L., Horvat, J. C., Wade, M. A., O'Sullivan, B. J., Thomas, R., Beagley, K. W., Gibson, P. G., Foster, P. S. and Hansbro, P. M. (2011) Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. European Respiratory Journal, 37 1: 53-64. doi:10.1183/09031936.00049510
Thorburn, Alison N., O'Sullivan, Brendan J., Thomas, Ranjeny, Kumar, Rakesh K., Foster, Peter S., Gibson, Peter G. and Hansbro, Philip M. (2010) Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax, 65 12: 1053-1060. doi:10.1136/thx.2009.131508
IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes
Hadis, Usriansyah, Leggatt, Graham R., Thomas, Ranjeny, Frazer, Ian H. and Kovacs, Eva M. (2010) IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Experimental Dermatology, 19 8: 723-729. doi:10.1111/j.1600-0625.2010.01092.x
Isomura, Iwao, Palmer, Stephanie, Grumont, Raelene J., Bunting, Karen, Hoyne, Gerard, Wilkinson, Nancy, Banerjee, Ashish, Proietto, Anna, Gugasyan, Raffi, Wu, Li, McNally, Alice, Steptoe, Raymond J., Thomas, Ranjeny, Shannon, M. Frances and Gerondakis, Steve (2010) c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells (vol 206, pg 3001, 2009). Journal of Experimental Medicine, 207 4: .
The balancing act of autoimmunity: Central and peripheral tolerance versus infection control
Thomas, Ranjeny (2010) The balancing act of autoimmunity: Central and peripheral tolerance versus infection control. International Reviews of Immunology, 29 2: 211-233. doi:10.3109/08830180903434219
A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity
Schroder, Wayne A., Le, Thuy T. T., Major, Lee, Street, Shayna, Gardner, Joy, Lambley, Eleanore, Markey, Kate, MacDonald, Kelli P., Fish, Richard J., Thomas, Ranjeny and Suhrbier, Andreas (2010) A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity. Journal of Immunology, 184 5: 2663-2670. doi:10.4049/jimmunol.0902187
Kenna, Tony J., Waldie, Tanya, McNally, Alice, Thomson, Meagan, Yagita, Hideo, Thomas, Ranjeny and Steptoe, Raymond J. (2010) Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. Journal of Immunology, 184 2: 598-606. doi:10.4049/jimmunol.0900032
c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G., Wilkinson, N., Banerjee, A., Proietto, A., Gugasyan, R., Li, W., McNally, Alice, Steptoe, Raymond J., Thomas, Ranjeny, Shannon, F. and Gerondakis, S. (2009) c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells. The Journal of Experimental Medicine, 206 13: 3001-3014. doi:10.1084/jem.20091411
Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selection
Doan, Tracy, McNally, Alice, Thomas, Ranjeny and Steptoe, Raymond (2009) Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selection. Immunology and Cell Biology, 87 8: 615-622. doi:10.1038/icb.2009.46
Hannawi, Suad, Marwick, Thomas and Thomas, Ranjeny (2009) Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis. Arthritis Research and Therapy, 11 2: R51.1-R51.7. doi:10.1186/ar2668
Antigen-specific suppression of inflammatory arthritis using liposomes
Capini, Christelle, Jaturanpinyo, Montree, Chang, Hsin-I, Mutalik, Srinivas, McNally, Alice, Street, Shayna, Steptoe, Raymond, O'Sullivan, Brendan, Davies, Nigel and Thomas, Ranjeny (2009) Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182 6: 3556-3565. doi:10.4049/jimmunol.0802972
Chen, Yueh-Sheng, Yan, Weixing, Geczy, Carolyn L., Brown, Matthew A. and Thomas, Ranjeny (2009) Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. Arthritis Research and Therapy, 11 2: R39 .1-R39 .11. doi:10.1186/ar2645
Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity
Pai, Saparna and Thomas, Ranjeny (2008) Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity. Journal of Autoimmunity, 31 3: 245-251. doi:10.1016/j.jaut.2008.04.012
Thomas, Ranjeny, Turner, Malcolm and Cope, Andrew P. (2008) High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?. Arthritis Research and Therapy, 10 4: 1-9. doi:10.1186/ar2446
Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes
Mollah, Zia U.A., Pai, Saparna, Craig Moore, O'Sullivan, Brendan J., Harrison, Matthew J., Peng, Judy, Phillips, Karen, Prins, Johannes B., Cardinal, John and Thomas, Ranjeny (2008) Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes. Journal of Immunology, 180 5: 3166-3175. doi:10.4049/jimmunol.180.5.3166
Steady-state dendritic cells expressing cognate antgen terminate memory CD8+ T-cell responses
Kenna, Tony J., Thomas, Ranjeny and Steptoe, Raymond J. (2008) Steady-state dendritic cells expressing cognate antgen terminate memory CD8+ T-cell responses. Blood, 111 4: 2091-2100. doi:10.1182/blood-2007-07-103200
Hannawi, Suad, Haluska, Brian, Marwick, Thomas H. and Thomas, Ranjeny (2007) Atherosclerotic disease is increased in recent onset rheumatoid arthritis: a critical role for inflammation. Arthritis Research and Therapy, 9 6: R116.1-R116.9. doi:10.1186/ar2323
Cells of the synovium in rheumatoid arthritis: dendritic cells
Lutzky, Viviana, Suad Hannawi, Suad and Thomas, Ranjeny (2007) Cells of the synovium in rheumatoid arthritis: dendritic cells. Arthritis Research and Therapy, 9 4: 219-230. doi:10.1186/ar2200
Plasmodium strain determines dendritic cell function essential for survival from malaria
Wykes, Michelle N., Liu, Xue Q., Beattie, Lynette, Stanisic, Danielle I., Stacey, Katryn J., Smyth, Mark J., Thomas, Ranjeny and Good, Michael F. (2007) Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathogens, 3 7: e96-0904-e96-0912. doi:10.1371/journal.ppat.0030096
MacDonald, Kelli P. A., Kuns, Rachel D., Rowe, Vanessa, Morris, Edward S., Banovic, Tatjana, Bofinger, Helen, O'Sullivan, Brendan, Markey, Kate A., Don, Alistair L., Thomas, Ranjeny and Hill, Geoffrey R. (2007) Effector and regulatory T cell function is differentially regulated by RelB within antigen presenting cells during GVHD. Blood, 109 11: 5049-5057. doi:10.1182/blood-2007-01-067249
Carroll, Lisa, Frazer, Ian H., Turner, Malcolm, Marwick, Thomas H. and Thomas, Ranjeny (2007) Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis. Arthritis Research and Therapy, 9 2: R39.1-R39.8. doi:10.1186/ar2175
Pai, Saparna, O'Sullivan, Brendan, Abdul-Jabbar, Ibtissam, Peng, Judy, Connoly, Geoff, Khanna, Rajiv and Thomas, Ranjeny (2007) Nasopharyngeal carcinoma-associated Epstein-Barr virus encoded oncogene latent membrane protein 1 potentiates regulatory T cell function. Immunology and Cell Biology, 85 5: 370-377. doi:10.1038/sj.icb.7100046
Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-κB
Martin, E., Capini, C., Duggan, E., Lutzky, V. P., Stumbles, P., Pettit, A. R., O'Sullivan, B. and Thomas, R. (2007) Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-κB. Arthritis And Rheumatism, 56 7: 2255-2266. doi:10.1002/art.22655
Identification and isolation of synovial dendritic cells
Pettit, Allison R., Cavanagh, Lois, Boyce, Amanda, Padmanabha, Jagadish, Peng, Judy and Thomas, Ranjeny (2007) Identification and isolation of synovial dendritic cells. Methods in Molecular Medicine, 136 165-181.
NF-kappa B as a therapeutic target in autoimmune disease
O'Sullivan, Brendan J., Thompson, Angus and Thomas, Ranjeny (2007) NF-kappa B as a therapeutic target in autoimmune disease. Expert Opinion On Therapeutic Targets, 11 2: 111-122. doi:10.1517/14728222.11.2.111
Liu, Xiao Song, Dyer, Joanne, Leggatt, Graham R., Fernando, Germain J. P., Zhong, Jie, Thomas, Ranjeny and Frazer, Ian H. (2006) Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host. Journal of Immunology, 177 5: 2873-2879. doi:10.4049/jimmunol.177.5.2873
IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells
O'Sullivan, Brendan J., Thomas, Helen E., Pai, Saparna, Santamaria, Pere, Iwakura, Yoichiro, Steptoe, Raymond J., Kay, Thomas W. H. and Thomas, Ranjeny (2006) IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells. Journal of Immunology, 176 12: 7278-7287. doi:10.4049/jimmunol.176.12.7278
Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritis
Roberts, Lynden J., Cleland, Leslie G., Thomas, Ranjeny and Proudman, Susanna M. (2006) Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritis. Medical Journal of Australia, 184 3: 122-125.
Dendritic cell immunotherapy for melanoma
Peng, J. C., Thomas, R and Dredge, K. (2006) Dendritic cell immunotherapy for melanoma. Reviews on Recent Clinical Trials, 1 2: 87-102. doi:10.2174/157488706776876517
Thomas, Ranjeny (2006) Editorial. Wiener medizinische Wochenschrift [electronic resource]., 156 1-2: 1-1. doi:10.1007/s10354-006-0269-6
IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
Peng, J. C., Abu Bakar, S., Richardson, M. M., Jonsson, J. J., Frazer, I. H., Nielsen, L. K., Morahan, G. and Thomas, R. (2006) IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS. Immunology And Cell Biology, 84 2: 227-232. doi:10.1111/j.1440-1711.2006.01419.x
Peng, Judy C., Hyde, Claire, Pai, Saparna, O'Sullivan, Brendan J., Nielsen, Lars K. and Thomas, Ranjeny (2006) Monocyte-derived DC primed with TLR agonists secrete IL-12p70 in a CD40-dependent manner under hyperthermic conditions. Journal of Immunotherapy, 29 6: 606-615. doi:10.1097/01.cji.0000211308.82997.4e
Carroll, Lisa, Hannawi, Suad, Marwick, Thomas and Thomas, Ranjeny (2006) Rheumatoid arthritis: links with cardiovascular disease and the receptor for advanced glycation end products. Wiener Medizinische Wochenschrift, 156 1-2: 42-52. doi:10.1007/s10354-005-0242-9
Hewavitharana, A. K., Hyde, C., Thomas, R. and Shaw, P. N. (2006) Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 1-2: 93-97. doi:10.1016/j.jchromb.2006.02.037
Generation and maturation of dendritic cells for clinical application under serum-free conditions
Peng, Judy C., Thomas, Ranjeny and Nielsen, Lars K. (2005) Generation and maturation of dendritic cells for clinical application under serum-free conditions. Journal of Immunotherapy, 28 6: 599-609. doi:10.1097/01.cji.0000175491.21099.04
MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005) The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 3: 1399-1405. doi:10.4049/jimmunol.175.3.1399
The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation
Thomas, Ranjeny (2005) The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation. Arthritis Research and Therapy, 7 4: 170-173. doi:10.1186/ar1784
MacDonald, Kelli P. A., Rowe, Vanessa, Clouston, Andrew D., Welply, Joseph K., Kuns, Rachel D., Ferrara, James L. M., Thomas, Ranjeny and Hill, Geoffrey R. (2005) Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. Journal of Immunology, 174 4: 1841-1850. doi:10.4049/jimmunol.174.4.1841
Rheumatoid arthritis synovium contains plasmacytoid dendritic cells
Cavanagh, Lois L., Boyce, Amanda, Smith, Louise, Padmanabha, Jagadish, Filgueira, Luis, Pietschmann, Peter and Thomas, Ranjeny (2005) Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. Arthritis Research and Therapy, 7 2: R230-R240. doi:10.1186/ar1467
Yan, Mengyong, Peng, Judy, Jabbar, Ibtissam A., Liu, Xiaosong, Filguueira, Luis, Frazer, Ian H. and Thomas, Ranjeny (2005) Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-B-mediated signalling, moderated by TGF-beta. Immunology and Cell Biology, 83 1: 83-91. doi:10.1111/j.1440-1711.2004.01291.x
Yan, Mengyong, Peng, Judy, Abdul Jabbar, Ibtissam A., Liu, Xiaosong, Filgueira, Luis, Frazer, Ian H. and Thomas, Ranjeny (2004) Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells. Virology, 324 2: 297-310. doi:10.1016/j.virol.2004.03.045
Juffs, Helen, Fowler, Nina, Saal, Russell, Grimmett, Karen, Beasley, Shannon, O'Sullivan, Brendan, Frazer, Ian H., Gill, Devinder and Thomas, Ranjeny (2004) B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma. Pathology, 36 1: 69-76. doi:10.1080/00313020310001644499
Signal 3 and its role in autoimmunity
Thomas, Ranjeny (2004) Signal 3 and its role in autoimmunity. Arthritis Research and Therapy, 6 1: 26-27. doi:10.1186/ar1033
T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation
Thompson, Angus G., O'Sullivan, Brendan J., Beamish, Heather and Thomas, Ranjeny (2004) T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation. Journal of Immunology, 173 3: 1671-1680. doi:10.4049/jimmunol.173.3.1671
MacDonald, Kelli P. A., Rowe, Vanessa, Filippich, Cheryl, Thomas, Ranjeny, Clouston, Andrew D., Welply, Joseph K., Hart, Derek N. J., Ferrara, James L. M. and Hill, Geoffrey R. (2003) Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation. Blood, 101 5: 2033-2042. doi:10.1182/blood-2002-05-1529
Martin, Ela, O'Sullivan, Brendan, Low, Pauline and Thomas, Ranjeny (2003) Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity, 18 1: 155-167. doi:10.1016/S1074-7613(02)00503-4
CD40 and dendritic cell function
O'Sullivan, Brendan and Thomas, Ranjeny (2003) CD40 and dendritic cell function. Critical Reviews In Immunology, 23 1-2: 83-107. doi:10.1615/CritRevImmunol.v23.i12.50
Smithers, Mark, O'Connell, Kathleen, MacFadyen, Susan, Chambers, Melita, Greenwood, Kathryn, Boyce, Amanda, Abdul-Jabbar, Ibtissam, Barker, Kylie, Grimmett, Karen, Walpole, Euan and Thomas, Ranjeny (2003) Clinical response after intradermal immature dendritic cell vaccination in metastatic melanoma is associated with immune response to particulate antigen. Cancer Immunology Immunotherapy, 52 1: 41-52. doi:10.1007/s00262-002-0318-y
Recent advances on the role of CD40 and dendritic cells in immunity and tolerance
O'Sullivan, Brendan and Thomas, Ranjeny (2003) Recent advances on the role of CD40 and dendritic cells in immunity and tolerance. Current Opinion In Hematology, 10 4: 272-278. doi:10.1097/00062752-200307000-00004
Mould, Arne W., Tonks, Ian D., Cahill, Marian M., Pettit, Allison R., Thomas, Ranjeny, Hayward, Nicholas K. and Kay, Graham F. (2003) Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Arthritis and Rheumatism, 48 9: 2660-2669. doi:10.1002/art.11232
Thompson, Angus G. and Thomas, Ranjeny (2002) Induction of immune tolerance by dendritic cells: implications for preventative and therapeutic immunotherapy of autoimmune disease. Immunology and Cell Biology, 80 6: 509-519. doi:10.1046/j.1440-1711.2002.01114.x
Liu, Wen Jun, Gao, Fengguang, Zhao, Kong Nan, Zhao, Weiming, Fernando, Germain J. G., Thomas, Ranjeny and Frazer, Ian H. (2002) Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity. Virology, 301 1: 43-52. doi:10.1006/viro.2002.1584
Pai, Saparna, O'Sullivan, Brendan J., Cooper, Leanne, Thomas, Ranjeny and Khanna, Rajiv (2002) RelB nuclear translocation mediated by C-terminal activator reigons of Epstein Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells. Journal of Virology, 76 4: 1914-1921. doi:10.1128/JVI.76.4.1914-1921.2002
O'Sullivan, Brendan J. and Thomas, Ranjeny (2002) CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappa B. Journal of Immunology, 168 11: 5491-5498. doi:10.4049/jimmunol.168.11.5491
Thompson, Angus G., Pettit, Allison R., Padmanabha, Jagdish, Mansfield, Helen, Frazer, Ian H ., Strutton, Geoff M. and Thomas, Ranjeny (2002) Nuclear RelB(+) cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditions. Immunology and Cell Biology, 80 2: 164-169. doi:10.1046/j.1440-1711.2002.01070.x
Thomas, R., Padmanabha, J., Chambers, M., McFadyen, S., Walpole, E., Nielssen, G. and Smithers, M. (2001) Metastatic lesions in the joint associated with acute inflammatory arthritis after dendritic cell immunotherapy for metastatic melanoma. Melanoma Research, 11 2: 167-173. doi:10.1097/00008390-200104000-00012
Pettit, AR, Weedon, H, Ahern, M, Zehntner, S, Frazer, IH, Slavotinek, J, Au, V, Smith, MD and Thomas, R (2001) Association of clinical, radiological and synovial immunopathological responses to anti-rheumatic treatment in rheumatoid arthritis. Rheumatology, 40 11: 1243-1255. doi:10.1093/rheumatology/40.11.1243
Pettit, A. R., Ahern, M. J., Zehntner, S., Smith, M. D. and Thomas, R. (2001) Comparison of differentiated dendritic cell infiltration of autoimmune and osteoarthritis synovial tissue. Arthritis And Rheumatism, 44 1: 105-110. doi:10.1002/1529-0131(200101)44:1<105::AID-ANR14>3.0.CO;2-3
Nelson, RT, Boyd, J, Gladue, RP, Paradis, T, Thomas, R, Cunningham, AC, Lira, P, Brissette, WH, Hayes, L, Hames, LM, Neote, KS and McColl, SR (2001) Genomic organization of the CC chemokine MIP-3 alpha/CCL20/LARC/EXODUS/SCYA20, showing gene structure, splice variants, and chromosome localization. Genomics, 73 1: 28-37. doi:10.1006/geno.2001.6482
Pettit, A. R., MacDonald, K. P., OSullivan, B. J. and Thomas, R. (2000) Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates. Arthritis And Rheumatism, 43 4: 791-800. doi:10.1002/1529-0131(200004)43:4<791::AID-ANR9>3.0.CO;2-E
Immunology of DNA vaccines: CpG motifs and antigen presentation
Manders, P and Thomas, R (2000) Immunology of DNA vaccines: CpG motifs and antigen presentation. Inflammation Research, 49 5: 199-205. doi:10.1007/s000110050580
O'Sullivan, Brendan J., MacDonald, Kelli P. A., Pettit, Allison R. and Thomas, Ranjeny (2000) RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function. Proceedings of the National Academy of Sciences of the United States of America, 97 21: 11421-11426. doi:10.1073/pnas.97.21.11421
Surface markers and transendothelial migration of dendritic cells from elderly subjects
Pietschmann, P, Hahn, P, Kudlacek, S, Thomas, R and Peterlik, M (2000) Surface markers and transendothelial migration of dendritic cells from elderly subjects. Experimental Gerontology, 35 2: 213-224. doi:10.1016/S0531-5565(99)00089-3
Dendritic cells and the pathogenesis of rheumatoid arthritis
Thomas, R., MacDonald, K. P. A., Pettit, A. R., Cavanagh, L. L., Padmanabha, J. and Zehntner, S. (1999) Dendritic cells and the pathogenesis of rheumatoid arthritis. Journal of Leukocyte Biology, 66 2: 286-292. doi:10.1002/jlb.66.2.286
Potential strategies utilised by papillomavirus to evade host immunity
Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian A., Leggatt, Graham R., Dunn, Linda, Mcmillan, Nigel A. J., Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula and Sharkey, Michael (1999) Potential strategies utilised by papillomavirus to evade host immunity. Immunological Reviews, 168 1: 131-142. doi:10.1111/j.1600-065X.1999.tb01288.x
Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?
Pettit, Allison R. and Thomas, Ranjeny (1999) Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?. Immunology and Cell Biology, 77 5: 420-427. doi:10.1046/j.1440-1711.1999.00855.x
Thomas, R, Chambers, M, Boytar, R, Barker, K, Cavanagh, LL, MacFadyen, S, Smithers, M, Jenkins, M and Andersen, J (1999) Immature human monocyte-derived dendritic cells migrate rapidly to draining lymph nodes after intradermal injection for melanoma immunotherapy. Melanoma Research, 9 5: 474-481. doi:10.1097/00008390-199910000-00007
Resistance of Rheumatoid Synovial Dendritic Cells to the Immunosuppressive Effects of IL-101
MacDonald, Kelli P. A., Pettit, Allison R., Quinn, Christopher, Thomas, Gregory J. and Thomas, Ranjeny (1999) Resistance of Rheumatoid Synovial Dendritic Cells to the Immunosuppressive Effects of IL-101. The Journal of Immunology, 163 10: 5599-5607.
Surfactant treatment for osteoarthritis
Vecchio, P, Thomas, R and Hills, BA (1999) Surfactant treatment for osteoarthritis. Rheumatology, 38 10: 1020-1021. doi:10.1093/rheumatology/38.10.1020
Tumor metastasis biopsy as a surrogate marker of response to melanoma immunotherapy
Zehntner, S, Townsend, W, Parkes, J, Schmidt, C, Down, M, Bell, J, Mulligan, R, ORourke, M, Ellem, K and Thomas, R (1999) Tumor metastasis biopsy as a surrogate marker of response to melanoma immunotherapy. Pathology, 31 2: 116-122. doi:10.1080/003130299105296
Antigen-presenting cells in rheumatoid arthritis
Thomas, R (1998) Antigen-presenting cells in rheumatoid arthritis. Springer Seminars In Immunopathology, 20 1-2: 53-72. doi:10.1007/BF00831999
Cavanagh, LL, Saal, RJ, Grimmett, KL and Thomas, R (1998) Proliferation in monocyte-derived dendritic cell cultures is caused by progenitor cells capable of myeloid differentiation. Blood, 92 5: 1598-1607.
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
MacDonald, K. P. A., Nishioka, Y., Lipsky, P. E. and Thomas, R. (1997) Functional CD40 ligand is expressed by T cells in rheumatoid arthritis. Journal of Clinical Investigation, 100 9: 2404-2414. doi:10.1172/JCI119781
Nuclear localization of RelB is associated with effective antigen-presenting cell function
Pettit, Allison R., Quinn, Christopher, MacDonald, Kellie P. A., Cavanagh, Lois L., Thomas, Greg, Townsend, Wendy, Handel, Malcolm and Thomas, Ranjeny (1997) Nuclear localization of RelB is associated with effective antigen-presenting cell function. Journal of Immunology, 159 8: 3681-3691.
Peripheral blood chimerism following human liver transplantation
Jonsson, JR, HoganPG, ThomasR, SteadmanC, CloustonAD, BaldersonGA, LynchSV, StrongRW and PowellEE (1997) Peripheral blood chimerism following human liver transplantation. Hepatology, 25 5: 1233-1236. doi:10.1002/hep.510250528
Functional differentiation of dendritic cells in rheumatoid arthritis - Role of CD86 in the synovium
Thomas, R and Quinn, C (1996) Functional differentiation of dendritic cells in rheumatoid arthritis - Role of CD86 in the synovium. Journal of Immunology, 156 8: 3074-3086.
Dendritic cells: Origin and differentiation
Thomas, R and Lipsky, PE (1996) Dendritic cells: Origin and differentiation. Stem Cells, 14 2: 196-206. doi:10.1002/stem.140196
Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
Thomas, R and Lipsky, PE (1996) Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?. Immunology Today, 17 12: 559-564. doi:10.1016/S0167-5699(96)20030-1
Thomas, R and Lipsky, PE (1996) Presentation of self peptides by dendritic cells: Possible implications for the pathogenesis of rheumatoid arthritis. Arthritis and Rheumatism, 39 2: 183-190. doi:10.1002/art.1780390202
CD80 expression in rheumatoid arthritis: Comment
Thomas, R and Lipsky, PE (1995) CD80 expression in rheumatoid arthritis: Comment. Arthritis and Rheumatism, 38 12: 1863-1864. doi:10.1002/art.1780381227
Tortorella, C, Schulzekoops, H, Thomas, R, Splawski, JB, Davis, LS, Picker, LJ and Lipsky, PE (1995) Expression of Cd45Rb and Cd27 Identifies Subsets of Cd4(+) Memory T-Cells with Different Capacities to Induce B-Cell Differentiation. Journal of Immunology, 155 1: 149-162.
Elevated interleukin-10 levels in patients with rheumatoid arthritis
Cush, JJ, Splawski, JB, Thomas, R, McFarlin, JE, Schulzekoops, H, Davis, LS, Fujita, K and Lipsky, PE (1995) Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis and Rheumatism, 38 1: 96-104. doi:10.1002/art.1780380115
Thomas, R and Lipsky, PE (1994) Human Peripheral-Blood Dendritic Cell Subsets - Isolation and Characterization of Precursor and Mature Antigen-Presenting Cells. Journal of Immunology, 153 9: 4016-4028.
Davis, LS, McIlraith, MJ, Paecheo, T, Becker, B, Adix, LM, Thomas, R, Wacholtz, MC and Lipsky, PE (1994) Assessment of a positive selection technique using an avidin column to isolate human peripheral blood T cell subsets. Journal of Immunological Methods, 175 2: 247-257. doi:10.1016/0022-1759(94)90367-0
Angiocentric T-Cell Lymphoma Masquerading as Cutaneous Vasculitis
Thomas, R, Vuitch, F and Lakhanpal, S (1994) Angiocentric T-Cell Lymphoma Masquerading as Cutaneous Vasculitis. Journal of Rheumatology, 21 4: 760-762.
Thomas, R, McIlraith, M, Davis, L and Lipsky, P (1994) Rheumatoid Synovial T-Cells Are Functionally Active and Can Contribute to the Pathogenesis of Rheumatoid-Arthritis - Comment On the Article by Matthews Et-Al. Arthritis and Rheumatism, 37 3: 445-446. doi:10.1002/art.1780370326
Rheumatoid Synovium Is Enriched in Mature Antigen-Presenting Dendritic Cells
Thomas, R, Davis, LS and Lipsky, PE (1994) Rheumatoid Synovium Is Enriched in Mature Antigen-Presenting Dendritic Cells. Journal of Immunology, 152 5: 2613-2623.
Carroll, GJ, Thomas, R, Phatouros, CC, Atchison, MH, Leslie, AL, Cook, NJ and Dsouza, I (1994) Incidence, Prevalence and Possible Risk-Factors for Pneumonitis in Patients with Rheumatoid-Arthritis Receiving Methotrexate. Journal of Rheumatology, 21 1: 51-54.
Comparative Accessory Cell-Function of Human Peripheral-Blood Dendritic Cells and Monocytes
Thomas, R, Davis, LS and Lipsky, PE (1993) Comparative Accessory Cell-Function of Human Peripheral-Blood Dendritic Cells and Monocytes. Journal of Immunology, 151 12: 6840-6852.
Isolation and Characterization of Human Peripheral-Blood Dendritic Cells
Thomas, R, Davis, LS and Lipsky, PE (1993) Isolation and Characterization of Human Peripheral-Blood Dendritic Cells. Journal of Immunology, 150 3: 821-834.
Thomas, R and Carroll, GJ (1993) Reduction of leukocyte and interleukin-1β concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate. Arthritis and Rheumatism, 36 9: 1244-1252. doi:10.1002/art.1780360909
Thomas, R, McIlraith, M, Davis, LS and Lipsky, PE (1992) Rheumatoid Synovium Is Enriched in Cd45Rbdim Mature Memory T-Cells That Are Potent Helpers for B-Cell Differentiation. Arthritis and Rheumatism, 35 12: 1455-1465. doi:10.1002/art.1780351209
Thomas, R and French, Mah (1991) Pyomyositis Complicating the Acquired-Immunodeficiency-Syndrome - a Report of 2 Cases with Coexistent Neutropenia. Medical Journal of Australia, 154 7: 481-483.
COMPARISON OF MORTALITY IN RHEUMATOID ARTHRITIS AND DIABETES - THE HUNT POPULATION-BASED STUDY
Houge, Ingrid Saether, Hoff, Mari, Thomas, Ranjeny and Videm, Vibeke (2019). COMPARISON OF MORTALITY IN RHEUMATOID ARTHRITIS AND DIABETES - THE HUNT POPULATION-BASED STUDY. In: Poster Presentations. Annual European Congress of Rheumatology (EULAR), Madrid Spain, (299-300). Jun 12-15, 2019. doi:10.1136/annrheumdis-2019-eular.1781
Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice
Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. In: 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, (23-24). 10-14 June 2018. doi:10.1002/eji.201871000
Cardiorespiratory fitness in patients with rheumatoid arthritis
Liff, M. H., Hoff, M., Fremo, T., Wisloff, U., Thomas, R. and Videm, V. (2018). Cardiorespiratory fitness in patients with rheumatoid arthritis. In: Congress of the European League Against Rheumatism (EULAR), Amsterdam, Netherlands, (937-937). 13-16 June 2018. doi:10.1136/annrheumdis-2018-eular.5497
Bhuyan, Zaied Ahmed, Rahman, M. Arifur, Maradana, Muralidhara, Mehdi, Ahmed, Guggino, Giuliana, Leo, Paul, Rehaume, Linda, Brown, Matthew, Ciccia, Francesco and Thomas, Ranjeny (2018). Intestinal inflammatory regulation in murine and human spondyloarthropathy requires high-affinity T cell receptor-zeta chain-associated protein (ZAP) 70-mediated runt-related transcription factor (Runx) 3 activity. In: 2018 ACR/ARHP Annual Meeting, Chicago, Illinois, (2026-2027). 19-24 October 2018.
Wehr, Pascale, Nel, Hendrik, Law, Soi Cheng, Jansen, Diahann, La Gruta, Nicole, Reid, Hugh, Rossjohn, Jamie and Thomas, Ranjeny (2018). Pre-clinical clonally-expanded aggrecan89-103-specific CD4+T cells are a target for autoimmune arthritis prevention. In: 2018 ACR/ARHP Annual Meeting, Chicago, Illinois, (34-34). 19-24 October 2018.
Towards T cell tolerance in rheumatoid arthritis
Thomas, R. (2018). Towards T cell tolerance in rheumatoid arthritis. In: Congress of the European League Against Rheumatism (EULAR), Amsterdam, Netherlands, (34-34). 13-16 June 2018. doi:10.1136/annrheumdis-2018-eular.7793
Antigen specific immunotherapy for autoimmune disease targeting dendritic cells
Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. In: 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, (66-66). 29 October - 2 November 2017.
Baillet, Athan, Bhuyan, Zaied Ahmed, Douillard, Claire, Bozon, Aurelie, Armitage, Charles, Romand, Xavier, Minh Vu Chuong Nguyen,, Favier, Bertrand, Wells, Timothy, Beagley, Kenneth and Thomas, Ranjeny (2017). Chlamydia-Infected Macrophages: "Trojan Horses" for Dissemination of IL-23 and TNF-Mediated Inflammation in SKG Mouse Reactive Arthritis. In: 2017 ACR/ARHP Pediatric Rheumatology Symposium, San Diego, California, (). 3-8 November 2017.
Rehaume, Linda, Matigian, Nicholas, Ormerod, Kate, Kang, Alicia, Linedale, Richard, Zbarskaya, Olga, Kikly, Kristine, Daly, Joshua, Lachner, Nancy, Hugenholtz, Philip, Morrison, Mark, Le Cao, Kim-Anh and Thomas, Ranjeny (2017). IL-23 promotes fecal microbiota dysbiosis associated with susceptibility to spondyloarthritis and ileitis in ZAP-70 mutant SKG mice. In: ACR/ARHP Annual Meeting, San Diego, CA United States, (). 3-8 November 2017.
Benham, H., Nash, P., Thomas, R. and Van Driel, M. (2017). Identification of clinician and patient barriers to the implementation of a patient-centered treat to target strategy for rheumatoid arthritis in Australia. In: New Zealand Rheumatology Association and Australian Rheumatology Association with the Rheumatology Health Professionals Association Joint Annual Scientific Meeting, Auckland, New Zealand, (11-12). 20–23 May 2017. doi:10.1111/imj.13426
Rahman, M. Arifur, Montizaan, Daphne, Bhuyan, Zaied Ahmed, Rehaume, Linda and Thomas, Ranjeny (2017). Impaired Control of Autoreactive T Cell Expansion Is Coupled with Type-1 Regulatory T Cell Deficiency in BALB/c ZAP70W163C Mutant Mice. In: 2017 ACR/ARHP Pediatric Rheumatology Symposium, San Diego, California, (). 3-8 November 2017.
Benham, Helen, Chiu, Hedva, Tesiram, Joanne, Landsberg, Peter, Harrison, Andrew A., Nash, Peter, Thomas, Ranjeny and van Driel, Mieke (2017). Implementation of a Treat-to-Target Remission Strategy for Rheumatoid Arthritis in Australian Public and Private Rheumatology Clinics - Identification of Clinician and Patient Barriers. In: 2017 ACR/ARHP Annual Meeting, San Diego CA, United States, (530-531). 3–8 November 2017.
Mucosal-associated invariant T cells are an important source of TNF in rheumatoid arthritis
Jansen, Diahann, Klinken, Elizabeth, Nel, Hendrik, Law, Soi Cheng, Koppejan, Hester, Hameetman, Marjolijn, Liu, Ligong, Corbett, Alexandra, Eckle, Sidonia, Fairlie, David, Toes, Rene E. M., van Gaalen, Floris, Rossjohn, Jamie, McCluskey, James and Thomas, Ranjeny (2017). Mucosal-associated invariant T cells are an important source of TNF in rheumatoid arthritis. In: 2017 ACR/ARHP Annual Meeting, San Diego, California, (3918-2919). 3-8 November 2017.
Galea, Ryan, Nel, Hendrik, Talekar, Meghna, Cole, Suzanne, Cochlin, Karyn, Hitchcock, Shannon, Zeng, Bijun, Yekollu, Suman, Rossjohn, Jamie, Reid, Hugh, Malaviya, Ravi, Shealy, Dave, O'Sullivan, Brendan and Thomas, Ranjeny (2017). Skin Migratory Dendritic Cells Targeted and Tolerized By Calcitriol-Peptide Liposomes Supress Antigen-Specific Autoreactive T Cell Expansion and Memory Differentiation to Regulate Autoimmune Arthritis. In: 2017 ACR/ARHP Pediatric Rheumatology Symposium, San Diego, California, (). 3-8 November 2017.
Moentadj, Rabia, Rehaume, Linda, Cuiv, Paraic O., Ormerod, Kate, Maradana, Muralidhara, Lakis, Vanessa Anne, Morrison, Mark, Hugenholtz, Philip, Benham, Helen, Le Cao, Kim-Anh and Thomas, Ranjeny (2017). Streptococcus Species Enriched in the Oral Cavity of RA Patients: A Persistent Source of Peptidoglycan-Polysaccharide Polymers Which Drive Disseminated Synovial Inflammation. In: 2017 ACR/ARHP Annual Meeting, San Diego CA, United States, (626-627). 3–8 November 2017. doi:10.1002/art.40321
Steptoe, R., Al-Kouba, J., Coleman, M., Jessup, C., Starkey, M., Overgaard, N., Bridge, J., Horvat, J., Werder, R., Walters, S., Coates, P. T., Grey, S., Thomas, R., Wells, J., Hansbro, P., Phipps, S. and Davies, J. (2016). Ablation of pathogenic memory T-cell responses by bone marrow-mediated gene therapy under immune-preserving conditions. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (722-722). 21-26 August 2016.
Abnormalities of antigen presenting cells in type 1 diabetes
Boks, M., Buchanan, K., Nagl, L., Harris, M. and Thomas, R. (2016). Abnormalities of antigen presenting cells in type 1 diabetes. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (334-334). 21-26 August 2016.
Benham, Helen, Wood, John, Nagl, Lisa, Maradana, Muralidhara, Daly, Joshua, Lachner, Nancy, Hugenholtz, Philip and Thomas, Ranjeny (2016). An Australian prospective cohort of rheumatoid arthritis patients and their first-degree relatives characterising environmental, genetic, microbial and immune factors. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association, 57th Annual Scientific Meeting, Darwin, NT, Australia, (7-7). 30 April–4 May 2016. doi:10.1111/imj.13052
Benham, Helen, Jensen, Charmaine, Thomas, Ranjeny and Eley, Diann (2016). Clinician Researchers: Understanding the Barriers and Facilitators for Medical Students and Junior Doctors Considering a Career in Research. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association, 57th Annual Scientific Meeting, Darwin, NT, Australia, (26-26). 30 April–4 May 2016. doi:10.1111/imj.13052
Jansen, D. T. S. L., Nel, H. J., Ramnoruth, N., Tesiram, J., Nagl, L., Benham, H., Scally, S., Reed, H. H., Rossjohn, J. and Thomas, R. (2016). Collagen specific CD4+T-cells restricted by HLA-DRB1*0101 are selected into the repertoire and expand in disease in mice and patients with inflammatory arthritis. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (903-903). 21-26 August 2016. doi:10.1002/eji.201670200
Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice
Buckle, I, Steptoe, R. J., Thomas, R. and Hamilton-Williams, E. E. (2016). Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (911-911). 21-26 August 2016.
Garcia-Gonzalez, P. A., Schinnerling, K., Sepulveda, A., Ubilla-Olguin, G., Soto, L., Neira, O., Medhi, A. M., Nel, H. J., Catalan, D., Thomas, R., Verdugo, R. A. and Aguillon, J. C. (2016). Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (721-721). 21-26 August 2016.
Scally, S., Law, S. -C, van Heemst, J., Wieles, D., Moustakis, A., Papadopoulos, G., van der Woude, D., Hitchon, C., Robinson, D., Huizinga, T., Reid, H., Toes, R., El-Gabalawy, H., Rossjohn, J. and Thomas, R. (2016). Molecular basis for the increased susceptibility of Indigenous North American tribes to seropositive rheumatoid arthritis. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (317-317). 21-26 August 2016. doi:10.1002/eji.201670200
Law, S. C., Nel, H. J., Scally, S. W., Mehdi, A., Le Cao, K. -A, Rossjohn, J., Reid, H. H., La Gruta, N. L. and Thomas, R. (2016). Oligoclonally expanded CD4+T cells recognising citrulinated vimentin in peripheral blood of rheumatoid arthritis patients. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (933-933). 21-26 August 2016. doi:10.1002/eji.201670200
Rehaume, L. M., Kang, A., Zbarskaya, O., Mullaney, J. A., Kim, M., Cuiv, O. P., Angel, N., Lachner, N., Daly, J., Morrison, M., Hugenholtz, P. and Thomas, R. (2016). Profiling immunogenic bacteria within the microbiota of SKG mice associated with spondyloarthritis and ileitis using IgA-SEQ. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (276-276). 21-26 August 2016.
Rahman, M. A., Montizaan, D., Bhuyan, Z. A., Rehaume, L. M. and Thomas, R. (2016). Restraint of autoreactive T cell expansion is defective in female BALB/c ZAP70(W163C) mutant (SKG) mice. In: International Congress of Immunology (ICI 2016), Melbourne, Australia, (919-919). 21-26 August 2016.
Rehaume, Linda, Matigian, Nicholas, Kang, Alicia, Zbarskaya, Olga, Kikly, Kristine, Lachner, Nancy, Daly, Joshua, Hugenholtz, Philip, Morrison, Mark, Le Cao, Kim-Anh and Thomas, Ranjeny (2016). Treatment of ZAP-70 Mutant SKG Mice with Anti-IL-23 Antibody Alters Fecal Microbiota Composition and Prevents Outgrowth of Bacteria Associated with Susceptibility to Spondyloarthritis and Ileitis. In: 2016 ACR/ARHP Annual Meeting Abstract Supplement. 2016 ACR/ARHP Annual Meeting, Washington, DC United States, (). 11–16 November 2016 .
Law, Soi Cheng, Nel, Hendrik, Rossjohn, Jamie, Reid, Hugh H., La Gruta, Nicole L. and Thomas, Ranjeny (2015). Profiling at the Single-Cell Level Reveals Evidence for Antigen-Driven Oligoclonal Expansion of Citrullinated Vimentin-Specific CD4+T Cells in Peripheral Blood of Rheumatoid Arthritis (RA) Patients. In: Arthritis & Rheumatology. , , (). .
van Heemst, Jurgen, Scally, Stephen, Law, Soi Cheng, van der Woude, Diane, Hitchon, Carol, Robinson, David B., Huizinga, T. W. J., Reid, Hugh H., Toes, Rene E. M., El-Gabalawy, Hani, Rossjohn, Jamie and Thomas, Ranjeny (2015). The Shared Rheumatoid Arthritis HLA-DRB1 Susceptibility Epitope Shapes the Molecular Orientation of Citrulline and the Autoreactive T Cell Receptor Repertoire. In: Arthritis & Rheumatology. , , (). .
Rehaume, L., Zbarskaya, O., Kang, A., Bhuyan, Z., Ruscher, R., Benham, H., O Cuiv, P., Morrison, M. and Thomas, R. (2015). A Gender Bias in Gut Microbiota of Skg Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered by Beta-Glucan. In: Internal Medicine Journal. Australian Rheumatology Associationin conjunction with Rheumatology Health Professionals Association, 56th Annual Scientific Meeting, Adelaide, SA, Australia, (38-38). 23–26 May 2015. doi:10.1111/imj.12752
Interleukin-23 Mediates Psoriasis-Like Inflammation in the Skg Mouse Model of Spondyloarthropathy
Benham, H., Rehaume, L., Baillet, A., Bhuyan, Z., Bowman, J., Pang, D., Kikly, K., Strutton, G. and Ranjeny, T. (2015). Interleukin-23 Mediates Psoriasis-Like Inflammation in the Skg Mouse Model of Spondyloarthropathy. In: Special Issue: Australian Rheumatology Associationin conjunction with Rheumatology Health Professionals Association, 56th Annual Scientific Meeting. 56th Annual Scientific Meeting of the Australian Rheumatology Associationin conjunction with Rheumatology Health Professionals Association, Adelaide, SA Australia, (3-3). 23-26 May 2015. doi:10.1111/imj.12752
Rehaume, Linda, Kang, Alicia, Zbarskaya, Olga, Mullaney, Jane, Kim, Matthew, Cuiv, Paraic O., Angel, Nicola, Hugenholtz, Philip, Morrison, Mark and Thomas, Ranjeny (2015). Profiling Immunogenic Bacteria within the Microbiota of ZAP-70 Mutant SKG Mice Associated with Spondyloarthritis and Ileitis Using IgA-SEQ. In: 2015 ACR/ARHP Annual Meeting, San Francisco, CA, United States, (3406-3407). 6-11 November 2015.
Law, S., Rossjohn, J., Nel, H., La Gruta, N., Reid, H. and Thomas, R. (2015). Profiling the TCR repertoire in the Rheumatoid Arthritis (RA) Autoantigen-Specific Cd4+T-Cells At the Single-Cell Level. In: Australian Rheumatology Associationin conjunction with Rheumatology Health Professionals Association, 56th Annual Scientific Meeting, Adelaide, South Australia, (25-25). 23–26 May 2015. doi:10.1111/imj.12752
Cimt in Individuals with Rheumatoid Arthritis Compared to Individuals with Type 2 Diabetes Mellitus
Pahau, H., Thomas, R., Videm, V., Haluska, B. and Short, L. (2014). Cimt in Individuals with Rheumatoid Arthritis Compared to Individuals with Type 2 Diabetes Mellitus. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association 55th Annual Scientific Meeting. 55th Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association, Hobart, TAS Australia, (30-30). 17-20 May 2014. doi:10.1111/imj.12426
Live attenuated vaccines in rheumatic diseases
Thomas, R. (2014). Live attenuated vaccines in rheumatic diseases. In: 15th Annual European Congress of Rheumatology (EULAR), Paris, France, (50-50). Jun 11-14, 2014. doi:10.1136/annrheumdis-2014-eular.6193
Law, Soi-Cheng, Nel, Hendrik, Mehdi, Ahmed, Le Cao, Kim-Anh and Thomas, Ranjeny (2014). Multiple Mechanisms of Tolerance Characterize the Immune Response to Autologous Modified Dendritic Cells Exposed to Citrullinated Peptides in Patients with Rheumatoid Arthritis.. In: Special Issue: 2014 ACR/ARHP Annual Meeting Abstract Supplemen. 2014 ACR/ARHP Annual Meeting, Boston, MA United States, (S422-S422). 14-19 November 2014. doi:10.1002/art.38914
Anderson, Amy E., Pratt, Arthur G., Sedhom, Mamdouh, Nair, Nisha, Massey, Jonathan, Routledge, Christine, Hargreaves, Ben, Brown, Philip, Barton, Anne, Isaacs, John D. and Thomas, Ranjeny (2014). Phospho-STAT1/3 and Gene Expression Measurement in Circulating CD4(+) T Cells As Diagnostic Tools in Early Autoantibody-Negative Rheumatoid Arthritis.. In: Special Issue: 2014 ACR/ARHP Annual Meeting Abstract Supplemen. 2014 ACR/ARHP Annual Meeting, Boston, MA United States, (S1072-S1073). 14-19 November 2014. doi:10.1002/art.38914
Anderson, A. E., Pratt, A. G., Sedhom, M., Nair, N., Massey, J., Routledge, C., Hargreaves, B., Brown, P., Barton, A., Isaacs, J. D. and Thomas, R. (2014). Phospho-STAT1/3 measurement in circulating CD4+T-cells as a diagnostic tool in early autoantibody-negative rheumatoid arthritis. In: Special Issue: Abstracts of the British Society for Immunology Annual Congress. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, (182-182). 1-4 December 2014. doi:10.1111/imm.12407
Katikireddi, V, Shankaranarayana, S., Cummins, L., Pahau, H., Duggan, E. and Thomas, R. (2014). Safety and Retention of Triple Conventional Disease-Modifying Anti-Rheumatic Drug Therapy in Early Rheumatoid Arthritis. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association 55th Annual Scientific Meeting. 55th Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association, Hobart, TAS Australia, (27-28). 17-20 May 2014. doi:10.1111/imj.12426
Baillet, A., Rehaume, L., Benham, H., O'Meara, C., Armitage, C., Harvie, M., Velasco, J., Beagley, K. and Thomas, R. (2013). Chlamydia Muridarum Induces Reactive Arthritis in Skg Mice: Relationship of Host Immune Control to Inflammatory Disease. In: Annual European Congress of Rheumatology EULAR abstracts. Annual European Congress of Rheumatology - EULAR 2013, Spain, (308-308). 12 - 15 June 2013.
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, D., Velasco, Jared, Benham, Helen, Hasnain, Sumaira, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip, McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2013). Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.. In: Special Issue: 2013 Annual Meeting Abstract Supplement. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego Ca, (S1152-S1152). 25-30 October 2013. doi:10.1002/art.38216
Baillet, Athan, Rehaume, Linda, Benham, Helen, O'Meara, Connor, Armitage, Charles, Harvie, Marina, Brizard, Geraldine, Velasco, Jared, Forrester, John V., Degli-Esposti, Mariapia, Beagley, Kenneth and Thomas, Ranjeny (2013). Impaired Bacterial Clearance and An Exuberant Inflammatory Response Promote Chlamydia-Induced Reactive Arthritis In SKG Mice. In: Abstract Supplement 2013 Annual Meeting. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego CA, United States, (S1152-S1152). 25-30 October 2013. doi:10.1002/art.38216
Klinken, Elizabeth, Nel, Hanno and Thomas, Ranjeny (2013). Mucosal Associated Invariant T (Mait) Cell Numbers Are Reduced in the Peripheral Blood of Rheumatoid Arthritis Patients. In: Special Issue: Australasian Society of Clinical Immunology and Allergy (ASCIA) 24th Annual Scientific Meeting. Australasian Society of Clinical Immunology and Allergy (ASCIA) 24th Annual Scientific Meeting, Perth, Western Australia, (10-10). 11-13 September 1013. doi:10.1111/imj.12252
Thomas, Helen E., Graham, Kate L., Chee, Jonathan, Thomas, Ranjeny, Kay, Thomas W. and Krishnamurthy, Balasubramanian (2013). Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes. In: Narinder K. Mehra, Translational immunology in Asia-Oceania. 5th FIMSA Congress, New Dehli, India, (81-86). 14 -17 March 2012. doi:10.1111/j.1749-6632.2012.06797.x
Coleman, Miranda, Thomas, Ranjeny and Steptoe, Ray (2012). Antigen-targeting to dendritic cells is required for engraftment of antigen-encoding bone marrow and long-term tolerance under non-myeloablative conditions. In: Immunology 2012 Meeting Abstracts. 99th Annual Meeting of the American Association of Immunologists, Boston, MA, United States, (). 4 -8 May 2012.
Pahau, Helen, Videm, Vibeke, Paul, Sanjoy and Thomas, Ranjeny (2012). Cardiovascular risk factors and events are more frequent prior to the onset of rheumatoid arthritis than in the general population. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S512-S513). 9-14 November 2012. doi:10.1002/art.37735
Early rheumatoid arthritis management and potential vaccine-based therapeutics
Thomas, R. (2012). Early rheumatoid arthritis management and potential vaccine-based therapeutics. In: Abstracts for the RACP Future Directions in Health Congress 2012. RACP Future Directions in Health Congress 2012, Brisbane, QLD, Australia, (12-12). 6-9 May 2012. doi:10.1111/j.1445-5994.2012.02779.x
Thomas, Ranjeny, Rehaume, Linda, Aguirre de Cárcer, Daniel, Mondot, Stan, Velasco, Jared, Benham, Helen, Ruutu, Merja, Morrison, Mark and McGuckin, Michael (2012). Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S1053-S1053). 9-14 November 2012. doi:10.1002/art.37735
Outcome of a phase I trial of rheumavax in patients with rheumatoid arthritis
Nel, H., Law, S., Street, S., Ramnoruth, N., Shams, R., Pahau, H., Brunck, M., Hyde, C., O'Sullivan, B., Capini, C., Tran, A., Ng, J., Godfrey, D. and Thomas, R. (2012). Outcome of a phase I trial of rheumavax in patients with rheumatoid arthritis. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (10-10). 12-15 May 2012. doi:10.1111/j.1445-5994.2012.02761.x
Benham, H., Rehaume, L., Ruutu, M., Velasco, J., Strutton, G., McGuckin, M. and Thomas, R. (2012). Protective and Pathogenic Effects of the Il-23 Family of Cytokines in Spondyloarthropathy in Skg Mice. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (5-5). 12-15 May 2012. doi:10.1111/j.1445-5994.2012.02759.x
Benham, Helen, Rehaume, Linda, Ruutu, Merja, Velasco, Jared, Kikly, Kristine, Strutton, Geoffrey, McGuckin, Michael and Thomas, Ranjeny (2012). Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S1052-S1052). 9-14 November 2012. doi:10.1002/art.37735
Street, S., Purcell, A., Law, S., Yu, A., Capini, C., O'Sullivan, B., Pahau, H. and Thomas, R. (2011). PROINFLAMMATORY AND REGULATORY T CELL RESPONSES TO CITRULLINATED AUTOANTIGENIC PEPTIDES IN PERIPHERAL BLOOD OF SHARED EPITOPE plus RHEUMATOID ARTHRITIS PATIENTS. In: Internal Medicine Journal. , , (14-14). .
Thomas, Ranjeny, Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Law, Soi, Brunck, Marion, Hyde, Claire, O'Sullivan, Brendan, Capini, C., Tran, A., Ng, J. and Paul, S. (2011). Feasibility, safety and clinical effects of a single intradermal administration of autologous tolerising dendritic cells exposed to citrullinated peptides in patients with rheumatoid arthritis. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting. 75th Annual Scientific Meeting of the American College of Rheumatology/46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Chicago, IL, United States, (S946-S946). 04-09 November 2011. doi:10.1002/art.33310
Ruutu, Merja, Velasco, Jared, Aguirre, Daniel, Benham, Helen, Morrison, Mark, McGuckin, Michael and Thomas, Ranjeny (2011). The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice. In: Abstracts of the American College of Rheumatology and Association of Rheumatology Health Professionals Annual Scientific Meeting. 75th Annual Scientific Meeting of the American College of Rheumatology/46th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Chicago, IL, United States, (S668-S668). 4-9 November 2011. doi:10.1002/art.33310
O'Sullivan, B, Pai, S, Street, S, MacDonald, K, Gerondakis, S, Hill, G and Thomas, R (2010). Autoreactive T cells Eescaping thymic deletion in REL-B deficient mice depend on dendritic cell-encoded REL-B for control of autoimmunity. In: Abstract Supplement - 10th Annual Meeting, Federation of Clinical Immunology Societies. 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, Boston, MA, U.S.A., (S-134-S-135). 24-27 June 2010. doi:10.1016/j.clim.2010.03.407
Pai, S, Best, S, Roddick, J, Pahao, H, Baskerville, T, Brown, M, Harris, M, Cotterill, A and Thomas, R (2010). F.25. Activity of the REL-B and p65 subunits of NF-kappa B demonstrates innate immune activation in children at risk of type 1 diabetes. In: FOCIS 2010 Abstract Supplement :10th Annual Meeting, Federation of Clinical Immunology Societies. FOCiS 2010: Tenth Annual Meeting of the Federation of Clinical Immunology Societies, Boston, MA, U.S.A., (S82-S82). 24-27 June 2010. doi:10.1016/j.clim.2010.03.247
Bertin-Maghit, Sebastien, O'Sullivan, Brendan, Best, Shannoiin, Duggan, Emily, Pang, Dimeng, Thomas, Helen, Kay, Thomas, Harrison, Leonard, Steptoe, Raymond and Thomas, Ranjeny (2010). F.72. IL-1 beta produced in response to islet autoantigen presentation differentiates T-helper-17 cells at the expense of regulatory T cells: Implications for the timing of tolerizing immunotherapy. In: FOCIS 2010 Abstract Supplement :10th Annual Meeting, Federation of Clinical Immunology Societies. FOCiS 2010: Tenth Annual Meeting of the Federation of Clinical Immunology Societies, Boston, MA, U.S.A., (S98-S98). 24-27 June 2010. doi:10.1016/j.clim.2010.03.294
Pai, S., Best, S. E., Mollah, Z. U., Prins, J., Brown, M. and Thomas, R. (2008). RelB response to LPS: Characterizing the molecular mechanism of abnormal DC function in Type 1 Diabetes. In: Immunology. Annual Congress of the British-Society-of-Immunology, Glasgow Scotland, (42-42). Nov 17-21, 2008.
Assessment of liposomes for delivery of selected NFkB inhibitors
Jaturanpinyo, M., Thomas, R. and Davies, N. M. (2006). Assessment of liposomes for delivery of selected NFkB inhibitors. In: Transactions of the 33rd Annual Meeting and Exposition of the Controlled Release Society. 33rd Annual Meeting of the Controlled Release Society: The art of science, technology, and living, Vienna Austria / Austria Center, (1-2). 22-26 July 2006.
Capini, C., Hyde, C., O'Sullivan, B. and Thomas, R. (2006). Peripheral blood T cell reactivity to citrullinated autoantigenic peptides in Anti-CCP plus rheumatoid arthritis patients. In: Arthritis And Rheumatism. The 70th Annual Scientific Meeting of the American College of Rheumatology and 41st Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Washington, DC, U.S.A., (S509-S510). 10-15 November, 2006.
B, NK and NKT cells contribute to suppression of immunity by dendritic cells
Lutzky, V. P. and Thomas, R. (2005). B, NK and NKT cells contribute to suppression of immunity by dendritic cells. In: Tissue Antigens: 'Genetics and The Immune Response'Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. The 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop, Melbourne, Australia, (484-485). 29th November - 2nd December, 2005. doi:10.1111/j.1399-0039.2005.00523.x
Defective NF-kappaB Activation in Response to LPS in Type 1 Diabetes Dendritic Cells
Mollah, Z. U. A., Moore, C., Sullivan, B., Peng, J., Phillips, K., Cardinal, J., Prins, J. and Thomas, R. (2005). Defective NF-kappaB Activation in Response to LPS in Type 1 Diabetes Dendritic Cells. In: Munksgaard, Tissue Antigens: 'Genetics and The Immune Response', Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. The 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop, Melbourne, Australia, (496-496). 29th November - 2nd December, 2005. doi:10.1111/j.1399-0039.2005.00523.x
Effect of drug-protein interactions on drug assay
Hewavitharana, A., Shaw, N., Hyde, C. and Thomas, R. (2005). Effect of drug-protein interactions on drug assay. In: E. A. Davis and C. G. Sobey, Program & Abstracts: Joint Meeting of ASCEPT and APSA 2005. Joint Meeting of ASCEPT and APSA, Melbourne, Australia, (2-39). 4-7 December 2005.
Feasibility of left main coronary artery imaging in the clinical laboratory
Jenkins, Carly, Hannawi, Suad, Jeffriess, Leanne, Thomas, Ranjeny and Marwick, Thomas (2005). Feasibility of left main coronary artery imaging in the clinical laboratory. In: Heart Lung and Circulation: Abstracts for the Cardiac Society of Australia and New Zealand and International Society for Heart Research Annual Scientific Meeting. Cardiac Society of Australia and New Zealand Annual Scientific Meeting, Perth, W. A ., (S29-S29). 5-8 August 2005. doi:10.1016/j.hlc.2005.04.007
IL-1 breaks tolerance through inhibition of regulatory T cell function
O'Sullivan, B. J., Thomas, H. E., Pai, S., Steptoe, R. J., Kay, T. W. and Thomas, R. (2005). IL-1 breaks tolerance through inhibition of regulatory T cell function. In: Tissue Antigens: 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop, Melbourne, Australia, (505-505). 29th November - 2nd December, 2005. doi:10.1111/j.1399-0039.2005.00523.x
Il-1 beta breaks tolerance through inhibition of regulatory T cell function
O'Sullivan, B., Thomas, H., Jamieson, E., Pai, S., Steptoe, R., Kay, T. and Thomas, R. (2005). Il-1 beta breaks tolerance through inhibition of regulatory T cell function. In: Arthritis and Rheumatism. 69th Annual Scientific Meeting of the American-College-of-Rheumatology/40th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, San Diego, CA, (S487-S487). 12th - 17th December, 2005.
Dredge, K., O'Sullivan, B., Cameron, S., Walshe, J., Saunders, N., Hultqvist, M., Holmdahl, R. and Thomas, R. (2005). Inhibition of NF kappa B leads to an intracellular reducing environment in human monocyte-derived immature dendritic cells. In: Tissue Antigens: 'Genetics and The Immune Response' 35th Annual Scientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops. The 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop, Melbourne, Australia, (400-401). 29th November - 2nd December, 2005. doi:10.1111/j.1399-0039.2005.00523.x
Liposomal encapsulation of the NF-kB inhibitor, Bay 11-7082
Jaturanpinyo, M., Davies, N. M. and Thomas, R. (2005). Liposomal encapsulation of the NF-kB inhibitor, Bay 11-7082. In: E. A. Davis and C. G. Sobey, Program & Abstracts: Joint Meeting of ASCEPT and APSA 2005. Joint Meeting of ASCEPT and APSA, Melbourne, (2-56). 4-7 December 2005.
MacDonald, Kelli, Kuns, Rachel, Rowe, Vanessa, Don, Alistair, Morris, Edward, Thomas, Ranjeny and Hill, Geoffrey (2005). Nuclear translocation of ROB within host and donor antigen presenting cells is critical for the initiation and maintenance of acute graft-versus-host disease. In: Abstracts of the 47th Annual Meeting of the American Society of Hematology. 47th Annual Meeting of the American Society of Hematology, Atlanta, GA, United States, (137A-137A). 10 -13 December 2005.
Targeting Antigen-loaded Liposomes to Myeloid Antigen Presenting Cells
Capini, C., Jaturanpinyo, M., Gautam, A., Davies, N. and Thomas, R. (2005). Targeting Antigen-loaded Liposomes to Myeloid Antigen Presenting Cells. In: Tissue Antigens: 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops. 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (372-373). 29th November - 2nd December, 2005. doi:10.1111/j.1399-0039.2005.00523.x
The mechanism of inflammation in RelB deficient mice
Pai, S., O'Sullivan, B. J., MacDonald, K. P., Duggan, E., Gerondakis, S., Hill, G. and Thomas, R. (2005). The mechanism of inflammation in RelB deficient mice. In: Tissue Antigens: 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (507-507). 29 November - 2 December 2005.
MacDonald, K. P. A., Rowe, V., Thomas, R., Ferrera, J. L. M. and Hill, G. R. (2004). Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells. In: Immunology and Cell Biology. 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Canberra, Australia, (A15-A15). 31st March - 2nd April, 2004. doi:10.1111/j.1440-1711.2004.1259_2.x
Antigen-specific suppression of inflammatory arthritis by dendritic cells
Martin, E., O'Sullivan, B. J. and Thomas, R. (2003). Antigen-specific suppression of inflammatory arthritis by dendritic cells. In: Arthritis and Rheumatism. 67th Annual Scientific Meeting of the American College of-Rheumatology/38th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Orlando, Florida, U.S.A., (S150-S151). 23 - 28 October 2003.
Antigen-specific suppression of inflammatory arthritis by dendritic cells
Thomas, R., Martin, E. and O'Sullivan, B. J. (2003). Antigen-specific suppression of inflammatory arthritis by dendritic cells. In: Arthritis Research and Therapy. 3rd World Congress of the Global-Arthritis-Research-Network (GARN), Miyakazi, Japan, (S34-S34). 14th - 17th September, 2003. doi:10.1186/ar908
MacDonald, K. P. A., Rowe, V., Thomas, R., Welply, J. K., Woulfe, S., Ferrara, J. L. M. and Hill, G. R. (2003). Progenipoietin-1 and G-CSF expand a novel CD40(neg) APC that induces transplant tolerance through IL-10 producing regulatory T cells. In: Abstracts of the 45th Annual Meeting of the American Society of Hematology. 45th Annual Meeting of the American Society of Hematology, San Diego, CA, United States, (191A-191A). 6 - 9 December 2003.
Juffs, H. G., Boyce, A., Gill, D. and Thomas, R. (2001). Transduction of B-CLL cells with recombinant lentiviral human CD40 ligand and its effects on antigen presenting cell function. In: Abstracts of the 43rd Annual Meeting of the American Society of Hematology. 43rd Annual Meeting of the American Society of Hematology, Orlando, FL, United States, (152A-152A). 7-11 December 2001.
Pettit, A. R., Weedon, H., Ahern, M., Zehntner, S., Slavotinek, J., Au, V., Smith, M. D. and Thomas, R. (2000). Rheumatoid arthritis clinical activity and radiological progression are related to synovial dendritic cell, lymphocyte and macrophage infiltration and TNF alpha expression. In: American College of Rheumatology Annual Scientific Meeting, Philadelphia, PA, USA, (S156-S156). 28 October - 2 November 2000.
Dendritic cells in rheumatoid arthritis - A model autoimmune inflammatory site
Thomas, R. (1998). Dendritic cells in rheumatoid arthritis - A model autoimmune inflammatory site. In: -, -, (15-15). -.
Cavanagh, L. L., Saal, R. J., Grimmett, K. L. and Thomas, R. (1998). Proliferation in monocyte-derived dendritic cell cultures is due to cells capable of myeloid differentiation. In: -, -, (21-21). -.
Functional CD40-ligand is expressed by T cells in rheumatoid arthritis
MacDonald, K., Nishioka, Y., Lipsky, P. and Thomas, R. (1997). Functional CD40-ligand is expressed by T cells in rheumatoid arthritis. In: The journal of allergy and clinical immunology. AAAAI/AAI/CIS Joint Meeting, -, (s182-s182). 21st - 26th February, 1997. doi:10.1016/S0091-6749(97)81064-0
Nuclear localisation of relB is associated with potent antigen presenting cell function
Thomas, R., Pettit, A., Quinn, Christopher, MacDonald, K. and Cavanagh, L. (1997). Nuclear localisation of relB is associated with potent antigen presenting cell function. In: AAAAI/AAI/CIS Joint Meeting, -, (s450-s450). 21st – 26th February, 1997. doi:10.1016/S0091-6749(97)81067-6
Pettit, A. R., Quinn, C., Cavanagh, L. L., Thomas, G., Townsend, W., Handel, M. and Thomas, R. (1997). Rheumatoid arthritis synovial tissue and not synovial fluid, DC express high levels of active nuclear RelB. In: -, -, (610-610). -.
Rheumatoid synovial fluid dendritic cells are resistant to the inhibitory effects of IL-10
Thomas, R., Macdonald, K., Moore, K., Pettit, A., Quinn, C., Thomas, G. and OSullivan, B. (1997). Rheumatoid synovial fluid dendritic cells are resistant to the inhibitory effects of IL-10. In: Arthritis and Rheumatism. 61st National Scientific Meeting of the American College of Rheumatology and the 32nd National Scientific Meeting of the Association of Rheumatology Health Professionals, Washington D.C., U.S., (536-536). 8-12 November 1997.
Transendothelial migration of human dendritic cells
Cavanagh, L. L., Pietschmann, P., Stohlawetz, P., Klosner, G. and Thomas, R. (1997). Transendothelial migration of human dendritic cells. In: Arthritis and Rheumatism. -, -, (276-276). 1997.
Immunomodulating compositions, processes for their production and uses therefore
O'Sullivan, Brendan J. and Ranjeny, Thomas (2003). Immunomodulating compositions, processes for their production and uses therefore. 2003249780; PCT/AU2003/001021; WO2004/015056.
Australian Arthritis and Autoimmune Biobank Collaborative (A3BC)
(2019–2022) University of Sydney
New strategies for targeting immune evasion in children's brain tumours
(2019–2021) The Children's Hospital Foundation
Development of antigen-specific immunotherapy for Wegener's granulomatosis
(2018–2023) Research Donation Generic
Towards prevention of Rheumatoid Arthritis: Harnessing the power of probiotic species
(2018–2023) Research Donation Generic
(2018–2020) Immune Tolerance Network - NIAID/NIH under grant number 5UM1AI109565 - administered by Benaroya Research Institute at Virginia Mason
Resetting the tumour microenvironment to improve glioblastoma immunotherapy
(2018–2020) Cure Brain Cancer Foundation
Improved antigen-specific immunotherapy for cutaneous malignant melanoma
(2018–2019) Cancer Council Queensland
Oral liposomes for antigen-specific immunotherapy of type 1 diabetes
(2018–2019) Diabetes Australia Research Trust
The Relationship of IL-23 and the microbiota in the development of spondyloarthritis in SKG mice
(2018) Arthritis Foundation of Australia
(2017–2020) Juvenile Diabetes Research Foundation in Australia
Funds for the Purchase of Research Equipment
(2017–2018) Arthritis Foundation of Australia
Patient-centred treat-to-target in rheumatoid arthritis
(2017) Arthritis Foundation of Australia
(2016–2019) Benaroya Research Institute at Virginia Mason
Establishing A gnobiotic Germ-Free Mouse Facility
(2016–2017) Ian Potter Foundation
Patient-centred treat-to-target in rheumatoid arthritis
(2016–2017) ABBVIE Pty Ltd
Establishing a gnotobiotic germ-free mouse facility
(2016) UQ Major Equipment and Infrastructure
Modification of the microbiome to protect against spondyloarthropathy in SKG mice
(2016) Arthritis Foundation of Australia
The Australian human microbiota project-microbe isolation facility
(2016) UQ Major Equipment and Infrastructure
Immunological therapies for cancer, chronic infection and autoimmunity
(2015–2019) NHMRC Program Grant
(2015–2019) NHMRC Research Fellowship
(2015–2019) NHMRC Project Grant
Antigen-specific peptide immunotherapy targeting dendritic cells in type 1 diabetes
(2015–2017) Juvenile Diabetes Research Foundation - International
Biomarker signature in children with recent-onset T1D
(2015–2016) Juvenile Diabetes Research Foundation - International
(2015) Arthritis Foundation of Australia
Biomarkers of disease susceptibility in patients at risk of rheumatoid arthritis
(2014–2018) Research Donation Generic
Chlamydia induced uveitis in the SKG mouse model of Spondyloarthropthy
(2014–2015) UWA-UQ Bilateral Research Collaboration Award
Risk of diabetes progression in at-risk subjects with metabolic and inflammatory signatures
(2014–2015) Juvenile Diabetes Research Foundation - International
Calibration of single channel and liquid handling robots
(2014) UQ Major Equipment and Infrastructure
Chlamydia induced uveitis in the SKG mouse model of Spondyloarthropathy (Project Costs)
(2014) Arthritis Foundation of Australia
Multiplex High Throughput Bio-plex Protein Assay Platform
(2014) UQ Major Equipment and Infrastructure
Professorial Chair in Rheumatology
(2013–2020) Arthritis Foundation of Queensland
(2013–2014) PA Research Foundation
The Australian Diabetes Data Network (ADDN) Biobank
(2013–2014) Juvenile Diabetes Research Foundation in Australia
(2012–2018) Research Donation Generic
Pathogenesis of a new mouse model of ankylosing spondylitis
(2012–2014) NHMRC Project Grant
(2012–2014) PA Research Foundation
Comprehensive cell imaging facility (ARC LIEF Grant administered by QUT)
(2011–2012) ARC LIEF Collaborating/Partner Organisation Contributions
Assessing airway hyperreactivity using flexiVent
(2011) RL Cooper Medical Research Foundation Limited
Targeted Immunotherapy in the SKG model of inflammatory arthritis
(2011) Arthritis Foundation of Australia
Immunological therapies for cancer, chronic infection and autoimmunity
(2010–2014) NHMRC Program Grant
Pathological changes associated with chronic RelB activiation in T1D
(2010–2012) Juvenile Diabetes Research Foundation
(2010) UQ Major Equipment and Infrastructure
PET/CT (positron emission tomography - computed tomography)
(2010) UQ Major Equipment and Infrastructure
Using genes to assess the risk of inflammatory arthritis
(2010) Arthritis Foundation of Australia
(2009–2013) ARC Future Fellowships
(2009–2011) NHMRC Project Grant
(2009–2011) NHMRC Project Grant
(2009) PA Research Foundation
RelB response as a biomarker of diabetes susceptibility
(2008–2011) Juvenile Diabetes Research Foundation - International
(2008–2010) University of Melbourne
(2008) UQ Major Equipment and Infrastructure
(2008) RL Cooper Medical Research Foundation Limited
(2008) PA Research Foundation
Genetic and Genomic Analysis Research Facility
(2007) RL Cooper Medical Research Foundation Limited
Interleukin 1 and Tolerance in Type 1 Diabetes
(2006–2009) Juvenile Diabetes Research Foundation - International
Mechanisms of dendritic cell-induced T-cell tolerance
(2006–2008) NHMRC Project Grant
The protective effect of G82S RAGE on cardiovascular events in rheumatoid arthritis
(2006–2007) Australian Rotary Health Research Fund
Research Donation - Ms Lesleigh Thomson
(2006) Arthritis Foundation of Australia
Immunological therapies for cancer and autoimmunity
(2005–2009) NHMRC Program Grant
(2005–2006) Articulum Fellowship
(2005) NHMRC Equipment Grant
(2005) Australian Rotary Health Research Fund
Phase 1 clinical trial of autologous dendritic cells to induce antigen-specific tolerance
(2004) NHMRC Project - Development Grant
Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
(2003–2004) NHMRC Project Grant
Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
(2003–2004) NHMRC Project Grant
(2003–2004) Princess Alexandra Hospital R&D Foundation
(2003–2004) Juvenile Diabetes Research Foundation - International
Induction of antigen-specific tolerance through inhibition of RelB function in dendtritic cells
(2002–2004) NHMRC Project Grant
Dentritic cell function, migration and modulation in a murine model of inflammatory arthritis.
(2002) Princess Alexandra Hospital R&D Foundation
Regulation And function Of The Transcription Factor RelB In Human Dendritic Cells
(2001) Princess Alexandra Hospital R&D Foundation
Role of TNFa In Dendritic Cell Migration In A Mouse Model Of Arthritis
(2001) Arthritis Foundation of Australia
(2000–2002) NHMRC Project Grant
Dendritic cell function, migration and modulation in a murine model of inflammatory arthritis
(2000) NHMRC Project Grant
Dendritic cell function, migration and modulation in a murine model of inflammatory arthritis
(2000) Princess Alexandra Hospital R&D Foundation
(2000) NHMRC Equipment Grant
(2000) Princess Alexandra Hospital R&D Foundation
Regulation and Function of the Transcription Factor RelB in Human Dendritic Cells
(1999–2001) NHMRC Project Grant
(1999–2000) Queensland Cancer Fund
(1999) Arthritis Foundation of Australia
The role of TAP and MHC Class I expression in the response to melanoma immunotherapy
(1999) Princess Alexandra Hospital R&D Foundation
Lymph Node Migration of Synovial Dendritic Cells in Auto Immune Arthritis
(1998–1999) Princess Alexandra Hospital R&D Foundation
Role of Inflammation on the Migration of Human Dendritic Cells
(1998–1999) Princess Alexandra Hospital R&D Foundation
(1998) Mayne Bequest Fund
Analysis of activated T cells from rheumatoid joints
(1998) Arthritis Foundation of Australia
Dr Luis Filgueira's three month placement at The University of Queensland
(1998) NHMRC - Strategic Funds
Transendothelial migration of human dendritic cells
(1997–1999) NHMRC Project Grant
Development of a melanoma vaccine comprising antologous dendritic cells
(1997–1998) Princess Alexandra Hospital Melanoma Trust Fund
Lymph node migration of synovial dendritic cells in normal joints and in autoimmune arthritis
(1997) Princess Alexandra Hospital R&D Foundation
Migration of dendritic cells through blood vessel walls
(1997) Arthritis Foundation of Australia
Transendothelial migration of human dendritic cells
(1997) Princess Alexandra Hospital R&D Foundation
Modulation of human dendritic cells function by monocytes, T cells and cytokines
(1996–1998) NHMRC Project Grant
Transendothelial migration of human blood dendritic cells
(1996–1997) Quality Funds Round 3
IL-10 and its effect on rheumatoid synovial dendritic cells
(1996) Arthritis Foundation of Australia
(1995–1997) Queensland Cancer Fund
The role of dendritic cells in Rheumatoid Arthritis
(1995–1997) Viertel Foundation (Sylvia and Charles Viertel)
Generation of large numbers of rheumatoid joint antigen-presenting cells
(1995–1996) Arthritis Foundation of Australia
(1995–1996) Queensland Cancer Fund
The role of HLA-DR as self-antigen in rheumatoid arthritis
(1995) UQ Foundation
The role of HLA-DR as self-antigen in rheumatoid arthritis
(1995) University of Queensland New Staff Research Grant
The role of HLA-DR as self-antigen in rheumatoid arthritis
(1995) Princess Alexandra Hospital R&D Foundation
The role of peripheral regulatory T cells in the predisposition to Spondyloarthritis
Doctor Philosophy — Principal Advisor
Other advisors:
Development of assays for T cell response to myeloperoxidase in MPO ANCA-associated vasculitis
Master Philosophy — Principal Advisor
Other advisors:
Immunogenic epitopes of the TSH receptor in Graves' disease
Doctor Philosophy — Principal Advisor
Other advisors:
Identification of Children with Type 1 Diabetes Suitable for Antigen-specific Tolerising Immunotherapy: T-cell response to relevant pancreatic islet peptides
Doctor Philosophy — Principal Advisor
Other advisors:
Unique T cell receptors (TCR) in autoimmune disease: biomarkers and therapeutic targets
Doctor Philosophy — Principal Advisor
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Factors influencing beta-cell destruction in type 1 diabetes
Doctor Philosophy — Principal Advisor
Nanoparticle delivery systems for antigen-specific immunotherapy in type 1 diabetes
Doctor Philosophy — Associate Advisor
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T cells specific for citrullinated-autoantigens in rheumatoid arthritis patients and at-risk individuals
() Doctor Philosophy — Principal Advisor
Mucosal associated invariant T (MAIT) cells in patients with rheumatoid arthritis
(2016) Master Philosophy — Principal Advisor
Cardiovascular Disease in Rheumatoid Arthritis
(2015) Doctor Philosophy — Principal Advisor
Cytokines and STAT3 signalling in autoimmune diseases
(2015) Doctor Philosophy — Principal Advisor
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Development of biomarkers in peripheral blood that could predict onset of type 1 diabetes
(2014) Doctor Philosophy — Principal Advisor
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Interleukin-23 signalling in spondyloarthropathy
(2014) Doctor Philosophy — Principal Advisor
Regulatory T cells, dendritic cells and RelB in autoimmunity and tolerance
(2014) Doctor Philosophy — Principal Advisor
sRAGE, S100 proteins and PTPN22 C1858T genetic polymorphism in rheumatoid arthritis
(2010) Master Philosophy — Principal Advisor
Early rheumatoid arthritis, Inflammation and Cardiovascular disease
(2008) Doctor Philosophy — Principal Advisor
THE RAGE GLYCINE 82 SERINE POLYMORPHISM AND CARDIOVASCULAR DISEASE IN RHEUMATOID ARTHRITIS
(2007) Master Philosophy — Principal Advisor
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
(2003) Doctor Philosophy — Principal Advisor
Other advisors:
CD40 Activated B-CLL Cells: an alternatie method for henerating an immune response & estalibshing autologous antigen-specific T cells for adoptive immunotherapy
(2002) Master Medical Science — Principal Advisor
Antigen-specific peptide immunotherapy for treatment and prevention of type 1 diabetes.
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
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Targeting Liver Inflammatory Myeloid Cells with Immunomodulatory Liposomes Improves Nonalcoholic Steatohepatitis in Mice
() Doctor Philosophy — Associate Advisor
Tailorable Nanocarrier Emulsion for Drug Delivery
(2015) Doctor Philosophy — Associate Advisor
Genetic variation in IL23R and its role in ankylosing spondylitis
(2013) Doctor Philosophy — Associate Advisor
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Non-myeloablative antigen-encoding bone marrow transplantation for CD8+ memory T cell tolerance
(2013) Doctor Philosophy — Associate Advisor
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The role of Mincle in the human innate immune response to Candida albicans
(2013) Doctor Philosophy — Associate Advisor
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LIPOSOMES FOR CO-DELIVERY OF SELECTED NF-kB INHIBITOR AND ANTIGEN FOR TREATMENT OF AUTOIMMUNE DISEASE
(2007) Doctor Philosophy — Associate Advisor
OPTIMIZATION OF DENDRITIC CELLS FOR CANCER IMMUNOTHERAPY
(2005) Doctor Philosophy — Associate Advisor
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