The University of Queensland

Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors

Chew, Hui Yi, Dolcetti, Riccardo and Simpson, Fiona (2020). Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors. British Journal of Clinical Pharmacology, 86 (9) bcp.14338, 1711-1725. doi: 10.1111/bcp.14338

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies

de Lima, Priscila Oliveira, Joseph, Shannon, Panizza, Benedict and Simpson, Fiona (2020). Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies. Current Treatment Options in Oncology, 21 (1) 9, 9. doi: 10.1007/s11864-019-0697-3

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190

Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis

Daniel, James A., Chau, Ngoc, Abdel-Hamid, Mohammed K., Hu, Lingbo, von Kleist, Lisa, Whiting, Ainslie, Krishnan, Sai, Maamary, Peter, Joseph, Shannon R., Simpson, Fiona, Haucke, Volker, McCluskey, Adam and Robinson, Philip J. (2015). Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis. Traffic, 16 (6), 635-654. doi: 10.1111/tra.12272

Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma

Foote, M. C., McGrath, M., Guminski, A., Hughes, B. G. M., Meakin, J., Thomson, D., Zarate, D., Simpson, F. and Porceddu, S. V. (2014). Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma. Annals of Oncology, 25 (10), 2047-2052. doi: 10.1093/annonc/mdu368

Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma

Joseph, Shannon R., Endo-Munoz, Liliana, Gaffney, Daniel C., Saunders, Nicholas A. and Simpson, Fiona (2015). Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma. Actinic keratosis. (pp. 20-27) edited by H. Peter Soyer, Tarl W. Prow and Gregor B.E. Jemec. Basel, Switzerland: S Karger AG. doi: 10.1159/000367959

Characterization of Rab23, a negative regulator of sonic hedgehog signaling

Evans, Timothy M., Simpson, Fiona, Parton, Robert G. and Wicking, Carol (2005). Characterization of Rab23, a negative regulator of sonic hedgehog signaling. GTPases regulating membrane targeting and fusion. (pp. 759-777) edited by William E. Balch, Channing J. Der and Alan Hall. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/S0076-6879(05)03066-1

Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck

de Lima, Priscila O., Broit, Natasa, Huang, Johnson D., Lim, Jae H., Gardiner, Damien J., Brown, Ian S., Panizza, Benedict J., Boyle, Glen M. and Simpson, Fiona (2023). Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck. Frontiers in Oncology, 13 ARTN 1231104, 1-16. doi: 10.3389/fonc.2023.1231104

Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats

Subasic, Christopher N., Butcher, Neville J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (9), 4468-4477. doi: 10.1021/acs.molpharmaceut.3c00102

Endocytosis in cancer and cancer therapy

Banushi, Blerida, Joseph, Shannon R., Lum, Benedict, Lee, Jason J. and Simpson, Fiona (2023). Endocytosis in cancer and cancer therapy. Nature Reviews Cancer, 23 (7), 1-24. doi: 10.1038/s41568-023-00574-6

Weaponizing natural killer cells for solid cancer immunotherapy

Wong, Joshua K.M., Dolcetti, Riccardo, Rhee, Handoo, Simpson, Fiona and Souza-Fonseca-Guimaraes, Fernando (2023). Weaponizing natural killer cells for solid cancer immunotherapy. Trends in Cancer, 9 (2), 111-121. doi: 10.1016/j.trecan.2022.10.009

Overlapping machinery in lysosome-related organelle trafficking: a lesson from rare multisystem disorders

Banushi, Blerida and Simpson, Fiona (2022). Overlapping machinery in lysosome-related organelle trafficking: a lesson from rare multisystem disorders. Cells, 11 (22) 3702, 1-26. doi: 10.3390/cells11223702

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis

McInerney-Leo, Aideen M., Chew, Hui Yi, Inglis, Po-Ling, Leo, Paul J., Joseph, Shannon R., Cooper, Caroline L., Okano, Satomi, Hassall, Tim, Anderson, Lisa, Bowman, Rayleen V., Gattas, Michael, Harris, Jessica E., Marshall, Mhairi S., Shaw, Janet G., Wheeler, Lawrie, Yang, Ian A., Brown, Matthew A., Fong, Kwun M., Simpson, Fiona and Duncan, Emma L. (2021). Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis. Human Molecular Genetics, 30 (24), 2393-2401. doi: 10.1093/hmg/ddab172

Evolution of cancer vaccines—challenges, achievements and future directions

Tay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535

Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: a review

Karlsen, Emma-Anne, Kahler, Sam, Tefay, Joan, Joseph, Shannon R. and Simpson, Fiona (2021). Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: a review. Cells, 10 (5) 1206, 1206. doi: 10.3390/cells10051206

Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy

Nightingale, James, Lum, Benedict, Ladwa, Rahul, Simpson, Fiona and Panizza, Benedict (2021). Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy. Biochimica et Biophysica Acta, 1875 (2) 188523, 1-9. doi: 10.1016/j.bbcan.2021.188523

Adenoid cystic carcinoma: a review of clinical features, treatment targets and advancement in improving the immune response to monoclonal antibody therapy

Nightingale, James, Lum, Benedict, Ladwa, Rahul, Simpson, Fiona and Panizza, Benedict (2021). Adenoid cystic carcinoma: a review of clinical features, treatment targets and advancement in improving the immune response to monoclonal antibody therapy. Biochimica et Biophysica Acta. Reviews on Cancer, 1875 (2) 188523, 1-9. doi: 10.1016/j.bbcan.2021.188523

Therapeutic implications of immune-profiling and EGFR expression in salivary gland carcinoma

Guazzo, Emily, Cooper, Caroline, Wilkinson, Lisa, Feng, Sophie, King, Brigid, Simpson, Fiona, Porceddu, Sandro, Panizza, Benedict and Coward, Jermaine I G (2020). Therapeutic implications of immune-profiling and EGFR expression in salivary gland carcinoma. Head and neck, 43 (3) hed.26529, 768-777. doi: 10.1002/hed.26529

Will next-generation immunotherapy overcome the intrinsic diversity and low immunogenicity of sarcomas to improve clinical benefit?

Chew, Hui Yi, Chan, Victor, Simpson, Fiona and Dolcetti, Riccardo (2020). Will next-generation immunotherapy overcome the intrinsic diversity and low immunogenicity of sarcomas to improve clinical benefit?. Cancers, 12 (11) 3392, 1-29. doi: 10.3390/cancers12113392

Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposure

Kuilamu, Esther, Subasic, Christopher, Cowin, Gary J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2020). Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposure. Pharmaceutical Research, 37 (11) 224, 1-12. doi: 10.1007/s11095-020-02945-2

Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples

Joseph, Shannon R., Lum, Benedict, Banushi, Blerida, Barry, Rachael, Panizza, Benedict, Walpole, Euan and Simpson, Fiona (2020). Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples. STAR Protocols, 1 (2) 100087, 100087. doi: 10.1016/j.xpro.2020.100087

Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors

Chew, Hui Yi, Dolcetti, Riccardo and Simpson, Fiona (2020). Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors. British Journal of Clinical Pharmacology, 86 (9) bcp.14338, 1711-1725. doi: 10.1111/bcp.14338

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?

Masterson, Liam, Howard, James, Gonzalez-Cruz, Jazmina, Jackson, Christopher, Barnett, Catherine, Overton, Lewis, Liu, Howard, Ladwa, Rahul, Simpson, Fiona, McGrath, Margie, Wallwork, Ben, Jones, Terry, Ottensmeier, Christian, Chua, Melvin L. K., Perry, Chris, Khanna, Rajiv, Panizza, Benedict, Porceddu, Sandro and Lechner, Matt (2020). Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?. International Journal of Cancer, 146 (8) ijc.32869, 2305-2314. doi: 10.1002/ijc.32869

Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies

de Lima, Priscila Oliveira, Joseph, Shannon, Panizza, Benedict and Simpson, Fiona (2020). Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies. Current Treatment Options in Oncology, 21 (1) 9, 9. doi: 10.1007/s11864-019-0697-3

Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190

Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma

Jung, Ji-Won, Veitch, Margaret, Bridge, Jennifer A., Overgaard, Nana H., Cruz, Jazmina L., Linedale, Richard, Franklin, Michael E., Saunders, Nicholas A., Simpson, Fiona, Frazer, Ian H., Steptoe, Raymond J. and Wells, James W. (2018). Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma. OncoImmunology, 7 (9) e1479627, 1-16. doi: 10.1080/2162402X.2018.1479627

Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab

He, Xuzhi, Cruz, Jazmina L., Joseph, Shannon, Pett, Nicola, Chew, Hui Yi, Tuong, Zewen K., Okano, Satomi, Kelly, Gabrielle, Veitch, Margaret, Simpson, Fiona and Wells, James W. (2018). Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Oncotarget, 9 (15), 12250-12260. doi: 10.18632/oncotarget.24242

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients

Linedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017). Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 (4) e0175755, e0175755.1-e0175755.13. doi: 10.1371/journal.pone.0175755

The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer

Pera, Elena, Kaemmerer, Elke, Milevskiy, Michael J. G., Yapa, Kunsala T. D. S., O'Donnell, Jake S., Brown, Melissa A., Simpson, Fiona, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell International, 16 (24) 24, 24. doi: 10.1186/s12935-016-0299-0

RacGAP1 is a novel downstream effector of E2F7-dependent resistance to doxorubicin and is prognostic for overall survival in squamous cell carcinoma

Hazar-Rethinam, Mehlika, de Long, Lilia Merida, Gannon, Orla M., Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Saenz-Ponce, Natalia, Dantzic, Daniel D. E., Simpson, Fiona and Saunders, Nicholas A. (2015). RacGAP1 is a novel downstream effector of E2F7-dependent resistance to doxorubicin and is prognostic for overall survival in squamous cell carcinoma. Molecular Cancer Therapeutics, 14 (8), 1939-1950. doi: 10.1158/1535-7163.MCT-15-0076

Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis

Daniel, James A., Chau, Ngoc, Abdel-Hamid, Mohammed K., Hu, Lingbo, von Kleist, Lisa, Whiting, Ainslie, Krishnan, Sai, Maamary, Peter, Joseph, Shannon R., Simpson, Fiona, Haucke, Volker, McCluskey, Adam and Robinson, Philip J. (2015). Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis. Traffic, 16 (6), 635-654. doi: 10.1111/tra.12272

Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?

Jung, Ji-Won, Overgaard, Nana H., Burke, Michael T., Isbel, Nicole, Frazer, Ian H., Simpson, Fiona and Wells, James W. (2015). Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?. International Journal of Cancer, 138 (2), 281-292. doi: 10.1002/ijc.29450

A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma

Hazar-Rethinam, Mehlika, Merida De Long, Lilia, Gannon, Orla M., Topkas, Eleni, Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Simpson, Fiona, Endo-Munoz, Liliana and Saunders, Nicholas A. (2015). A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma. Clinical Cancer Research, 21 (2), 417-427. doi: 10.1158/1078-0432.CCR-14-1962

Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage

Freeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928

Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma

Foote, M. C., McGrath, M., Guminski, A., Hughes, B. G. M., Meakin, J., Thomson, D., Zarate, D., Simpson, F. and Porceddu, S. V. (2014). Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma. Annals of Oncology, 25 (10), 2047-2052. doi: 10.1093/annonc/mdu368

The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target

Gaffney, Daniel C., Soyer, H. Peter and Simpson, Fiona (2014). The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target. Australasian Journal of Dermatology, 55 (1), 24-34. doi: 10.1111/ajd.12025

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041

Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives

Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131

KIAA0101 (KIAA0101)

Joseph, Shannon, Hu, Lingbo and Simpson, Fiona (2011). KIAA0101 (KIAA0101). Atlas of Genetics and Cytogenetics in Oncology and Haematology

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

Howes, Mark T., Kirkham, Matthew, Riches, James, Cortese, Katia, Walser, Piers J., Simpson, Fiona, Hill, Michelle M., Jones, Alun, Lundmark, Richard, Lindsay, Margaret R., Hernandez-Deviez, Delia J., Hadzic, Gordana, McCluskey, Adam, Bashir, Rumasia, Liu, Libin, Pilch, Paul, McMahon, Harvey, Robinson, Phillip J., Hancock, John F., Mayor, Satyajit and Parton, Robert G. (2010). Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. Journal of Cell Biology, 190 (4), 675-691. doi: 10.1083/jcb.201002119

Adiponectin-It's all about the modifications

Simpson, Fiona and Whitehead, Jonathan P. (2010). Adiponectin-It's all about the modifications. International Journal of Biochemistry & Cell Biology, 42 (6), 785-788. doi: 10.1016/j.biocel.2009.12.021

ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling

Charlton, HK, Webster, J, Kruger, S, Simpson, F, Richards, AA and Whitehead, JP (2010). ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. Biochemical and Biophysical Research Communications, 392 (2), 234-239. doi: 10.1016/j.bbrc.2010.01.029

Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation

Richards, AA, Colgrave, ML, Zhang, JL, Webster, J, Simpson, F, Preston, E, Wilks, D, Hoehn, KL, Stephenson, M, Macdonald, GA, Prins, JB, Cooney, GJ, Xu, AM and Whitehead, JP (2009). Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation. MOLECULAR ENDOCRINOLOGY, 24 (1), 229-239. doi: 10.1210/me.2009-0133

ATF3 and p15(PAF) are novel gatekeepers of genomic integrity upon UV stress

Turchi, L., Fareh, M., Aberdam, E., Kitajima, S., Simpson, F, Wicking, C., Aberdam, D. and Virolle, T. (2009). ATF3 and p15(PAF) are novel gatekeepers of genomic integrity upon UV stress. Cell Death and Differentiation, 16 (5), 728-737. doi: 10.1038/cdd.2009.2

Trafficking, development and hedgehog

Simpson, Fiona, Kerr, Markus C. and Wicking, Carol (2009). Trafficking, development and hedgehog. Mechanisms of Development, 126 (5 - 6), 279-288. doi: 10.1016/j.mod.2009.01.007

The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13

Bennetts, Jennifer S., Rendtorff, Nanna D., Simpson, Fiona, Tranebjaerg, Lisbeth and Wicking, Carol (2007). The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13. Developmental Dynamics, 236 (3), 843-852. doi: 10.1002/dvdy.21064

Murine embryonic expression of the gene for the UV-responsive protein p15(PAF)

Lammerts van Bueren, Kelly, Bennetts, Jennifer S., Fowles, Lindsay F., Berkman, Jennifer L., Simpson, Fiona and Wicking, Carol (2007). Murine embryonic expression of the gene for the UV-responsive protein p15(PAF). Gene Expression Patterns, 7 (1-2), 47-50. doi: 10.1016/j.modgep.2006.05.006

Visualisation of macropinosome maturation by the recruitment of sorting nexins

Kerr, Markus C., Lindsay, Margaret R., Luetterforst, Robert, Hamilton, Nicholas, Simpson, Fiona, Parton, Robert G., Gleeson, Paul A. and Teasdale, Rohan D. (2006). Visualisation of macropinosome maturation by the recruitment of sorting nexins. Journal Of Cell Science, 119 (19), 3967-3980. doi: 10.1242/jcs.03167

Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)

Bennetts, Jennifer S., Fowles, Lindsay F., Berkman, Jennifer L., Lammerts van Bueren, Kelly, Richman, Joy M., Simpson, Fiona and Wicking, Carol (2006). Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Gene, 374 (1-2), 153-165. doi: 10.1016/j.gene.2006.01.027

A rapidly evolving secretome builds and patterns a sea shell

Jackson, Daniel J., McDougall, Carmel, Green, Kathryn, Simpson, Fiona, Worheide, Gert and Degnan, Bernard M. (2006). A rapidly evolving secretome builds and patterns a sea shell. BMC Biology, 4 (40) 40, 40-49. doi: 10.1186/1741-7007-4-40

Identification and analysis of novel genes expressed in the mouse embryonic facial primordia

Bennetts, Jennifer S., Fowles, Lindsay F., Butterfield, Natalie C., Berkman, Jennifer L., Teasdale, Rohan D., Simpson, Fiona and Wicking, Carol (2006). Identification and analysis of novel genes expressed in the mouse embryonic facial primordia. Frontiers In Bioscience, 11 (SUPPL. 2), 2631-2646. doi: 10.2741/1997

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b

Simpson, Fiona, Lammerts van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, Simms, Lisa A., Young, Joanne, Walsh, Michael D., Leggett, Barbara, Fowles, Lindsay F. and Wicking, Carol (2006). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Experimental Cell Research, 312 (1), 73-85. doi: 10.1016/j.yexcr.2005.09.020

A Novel Mammalian Retromer Component, Vps26B

Kerr, Markus C., Bennetts, Jennifer S., Simpson, Fiona, Thomas, Elaine C., Flegg, Cameron, Gleeson, Paul A., Wicking, Carol and Teasdale, Rohan D. (2005). A Novel Mammalian Retromer Component, Vps26B. Traffic, 6 (11), 991-1001. doi: 10.1111/j.1600-0854.2005.00328.x

A novel hook-related protein family and the characterization of Hook-related protein 1

Simpson, Fiona, Martin, Sally, Evans, Timothy M., Kerr, Markus, James, David E., Parton, Robert G., Teasdale, Rohan D. and Wicking, Carol (2005). A novel hook-related protein family and the characterization of Hook-related protein 1. Traffic, 6 (6), 442-458. doi: 10.1111/j.1600-0854.2005.00289.x

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Larance, Mark, Ramm, Georg, Stockli, Jacqueline, van Dam, Ellen M., Winata, Stephanie, Wasinger, Valerie, Simpson, Fiona, Graham, Michael, Junutula, Jagath R., Guilhaus, Michael and James, David E. (2005). Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. Journal Of Biological Chemistry, 280 (45), 37803-37813. doi: 10.1074/jbc.M503897200

Insulin and Oleate Promote Translocation of Inosine-5' Monophosphate Dehydrogenase to Lipid Bodies

Whitehead, Jonathan P., Simpson, Fiona, Hill, Michelle M., Thomas, Elaine C., Connolly, Lisa M., Collart, Frank, Simpson, Richard J. and James, David E. (2004). Insulin and Oleate Promote Translocation of Inosine-5' Monophosphate Dehydrogenase to Lipid Bodies. Traffic, 5 (10), 739-749. doi: 10.1111/j.1600-0854.2004.00217.x

GLUT4 - At the cross roads between membrane trafficking and signal transduction

Simpson, Fiona, Whitehead, Jonathan P. and James, David E. (2001). GLUT4 - At the cross roads between membrane trafficking and signal transduction. Traffic, 2 (1), 2-11. doi: 10.1034/j.1600-0854.2001.020102.x

Casein kinase II activity is required for transferrin receptor endocytosis

Cotlin, LF, Siddiqui, MA, Simpson, F and Collawn, JF (1999). Casein kinase II activity is required for transferrin receptor endocytosis. Journal of Biological Chemistry, 274 (43), 30550-30556. doi: 10.1074/jbc.274.43.30550

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

Simpson, F., Hussain, N. K., Qualmann, B., Kelly, R. B., Kay, B. K., McPherson, P. S. and Schmid, S. L. (1999). SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nature Cell Biology, 1 (2), 119-124.

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

Simpson, F., Hussain, N. K., Qualmann, B., Kelly, R. B., Kay, B. K., McPherson, P. S. and Schmid, S. L. (1999). SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nature Cell Biology, 1 (2), 119-24. doi: 10.1038/10091

Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation

Jost, M, Simpson, F, Kavran, JM, Lemmon, MA and Schmid, SL (1998). Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Current Biology, 8 (25), 1399-1402. doi: 10.1016/S0960-9822(98)00022-0

Characterization of the adaptor-related protein complex, AP-3

Simpson, F., Peden, A. A., Christopoulou, L. and Robinson, M. S. (1997). Characterization of the adaptor-related protein complex, AP-3. Journal of Cell Biology, 137 (4), 835-845. doi: 10.1083/jcb.137.4.835

A novel adaptor-related protein complex

Simpson, F., Bright, N. A., West, M. A., Newman, L. S., Darnell, R. B. and Robinson, M. S. (1996). A novel adaptor-related protein complex. Journal of Cell Biology, 133 (4), 749-760. doi: 10.1083/jcb.133.4.749

HER2Pro: A Phase 1b dose de-escalation study of high dose prochlorperazine added to paclitaxel, trastuzumab and pertuzumab in patients with previously untreated HER2-positive metastatic breast cancer

Downton, Teesha, Karlsen, Emma, Cuff, Katharine, Walpole, Euan, Simpson, Fiona and Lim, Elgene (2023). HER2Pro: A Phase 1b dose de-escalation study of high dose prochlorperazine added to paclitaxel, trastuzumab and pertuzumab in patients with previously untreated HER2-positive metastatic breast cancer. 2022 San Antonio Breast Cancer Symposium, San Antonio, TX United States, 6-10 December 2022. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs22-ot2-10-05

Preclinical modeling of EGFR-specific mAb and immune pathways that impact immunotherapics for squamous cell carcinoma

He, Xuzhi, Gonzalez Cruz, Jazmina , Simpson, Finoa and Wells, James (2016). Preclinical modeling of EGFR-specific mAb and immune pathways that impact immunotherapics for squamous cell carcinoma. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne, Australia, 7-9 November 2016. Hoboken, NJ, United States: Wiley-Blackwell.

Preclinical modeling of EGFR-specific mAb and immune pathways that impact immunotherapics for squamous cell carcinoma

He, X., Cruz, Gonzalez J., Simpson, F. and Wells, J. (2016). Preclinical modeling of EGFR-specific mAb and immune pathways that impact immunotherapics for squamous cell carcinoma. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

Rapamycin, but not tacrolimus, promotes Cd8 memory T-cell differentiation and function in the skin

Jung, Ji-Won, Simpson, Fiona, Frazer, Ian H. and Wells, James W. (2016). Rapamycin, but not tacrolimus, promotes Cd8 memory T-cell differentiation and function in the skin. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne Exhibition and Convention Centre, Melbourne, Australia, 7-9 November 2016. Hoboken, NJ United States: Wiley-Blackwell Publishing.

The impact of rapamycin and tacrolimus treatment on resident CD8+T-cell populations in cutaneous squamous cell carcinoma

Jung, Ji-Won, Taylor, Paul J., Simpson, Fiona, Frazer, Ian H. and Wells, James W. (2016). The impact of rapamycin and tacrolimus treatment on resident CD8+T-cell populations in cutaneous squamous cell carcinoma. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-B055

Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells

Kaemmerer, Elke, Pere, Elena, Peters, Amelia A., Yapa, Kunsala T. D. S., Simpson, Fiona, O'Donnell, Jake, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells. APSA ASCEPT Joint Scientific Meeting 2015, Hobart, TAS Australia, 29 November - 2 December 2015.

Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study

Porceddu, S., Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Thomson, D. and Simpson, F. (2014). Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study. ELSEVIER SCIENCE INC. doi: 10.1016/j.ijrobp.2013.11.179

E2F7 regulates sensitivity to the cytotoxic actions of anthracyclins in squamous cell carcinoma

Rethinam, Mehlika Hazar, Saunders, Nicholas and Simpson, Fiona (2013). E2F7 regulates sensitivity to the cytotoxic actions of anthracyclins in squamous cell carcinoma. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, 6 - 10 April 2013. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1156/1538-7445.Alv2013-4359

Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study

Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Simpson, F. and Porceddu, S. (2013). Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam Netherlands, Sep 27-Oct 01, 2013. Oxford United Kingdom: Pergamon Press. doi: 10.1016/S0959-8049(13)70065-0

Estimation of EGF receptor expression and trafficking dysregulation in live tissue samples of cutaneous SCC and precursor lesions

Gaffney, D. C., Barry, R., Lambie, D., Porceddu, S. V., Foote, M., Strutton, G., Saunders, N. A., Soyer, H. P. and Simpson, F. (2011). Estimation of EGF receptor expression and trafficking dysregulation in live tissue samples of cutaneous SCC and precursor lesions. Australasian College of Dermatologists Biennial Spring Conference 2011, Hobart, Australia, 13-16 October 2011. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2011.00810.x

ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

Turchi, L., Fareh, M., Aberdam, E., Kitajima, S., Simpson, F., Wicking, C., Aberdam, D. and Virolle, T. (2008). ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. 20th Meeting of the European Association for Cancer Research, Lyon, France, 5-8 July 2008. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(08)71531-3

A novel RhoA inhibitor implicated in lip and palate formation

Town, L. J., Simpson, F., McGlinn, E. C., Butterfield, N., Richman, J. M. and Wicking, C. (2007). A novel RhoA inhibitor implicated in lip and palate formation. Society for Developmental Biology 66th Annual Meeting, Gran Meliá Hotel, Cancún, México, 16th – 20th June, 2007. Oxford: Elsevier Inc.. doi: 10.1016/j.ydbio.2007.03.512

A novel Gli3-regulated gene implicated in lip and palate formation

Town, L., McGlinn, E., Simpson, F., Richman, J. and Wicking, C. (2005). A novel Gli3-regulated gene implicated in lip and palate formation. AMSTERDAM: ELSEVIER SCIENCE BV.

Analysis of the subcellular role of a gene isolated from the craniofacial region of the mouse

Butterfield, N. C., Simpson, F., Bennetts, J. S., Fowles, L. F. and Wicking, C. A. (2005). Analysis of the subcellular role of a gene isolated from the craniofacial region of the mouse. Unknown, Unknown, Unknown. Amsterdam, Netherlands: Elsevier Science.

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1

Simpson, F., van Bueren, Lammerts K., Fowles, L., Berkman, J., Butterfield, N., Bowles, J., Adolphe, C., Simms, L., Young, J., Walsh, M. and Wicking, C. (2005). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1. Unknown, Unknown, Unknown. Amsterdam, Netherlands: Elsevier Science.

Identification and characterisation of novel genes with developmental significance

Bennetts, J., Fowles, L., Butterfield, N., van Bueren, Lammerts K., Berkman, J., Simpson, F. and Wicking, C. (2005). Identification and characterisation of novel genes with developmental significance. Unknown, Unknown, Unknown. Shannon, Co. Clare, Ireland: Elsevier Ireland.

Tissue distribution and synthesis of TRAMP (tyrosine rich acidic matrix protein) on fibroblast culture

Forbes, E. G., Cronshaw, A. D., Macbeath, J. R.E., Kerr, I. E., Coutts, S. R.J., Genschel, U. H., Simpson, F. and Hulmes, D. J.S. (1993). Tissue distribution and synthesis of TRAMP (tyrosine rich acidic matrix protein) on fibroblast culture.