Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Journal Article: Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity
Wright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960
Journal Article: Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure
Causer, Andrew, Tan, Xiao, Lu, Xuehan, Moseley, Philip, Teoh, Siok M., Molotkov, Natalie, McGrath, Margaret, Kim, Taehyun, Simpson, Peter T, Perry, Christopher, Frazer, Ian H., Panizza, Benedict, Ladwa, Rahul, Nguyen, Quan and Gonzalez-Cruz, Jazmina L. (2023). Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure. n p j Precision Oncology, 7 (1) 89, 89. doi: 10.1038/s41698-023-00444-2
Journal Article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts
Veitch, Margaret, Beaumont, Kimberly, Pouwer, Rebecca, Chew, Hui Yi, Frazer, Ian H, Soyer, H Peter, Campbell, Scott, Dymock, Brian W, Harvey, Andrew, Cock, Terrie-Anne and Wells, James W (2023). Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts. Journal for ImmunoTherapy of Cancer, 11 (9) e006783, e006783. doi: 10.1136/jitc-2023-006783
(2022–2025) Metro South Hospital and Health Service
(2022–2025) Griffith University
(2022–2024) The Hebrew University of Jerusalem
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Doctor Philosophy
Pathogen Promoters of Squamous Epithelial Cancer
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
(2021) Doctor Philosophy
The current status of development of prophylactic vaccines against Human Papillomavirus infection
Frazer, Ian and Vaccine Development Team (1999). The current status of development of prophylactic vaccines against Human Papillomavirus infection. Geneva, Switzerland: World Health Organization.
Frazer, Ian H. (2010). Human papillomaviruses. Vaccines: a biography. (pp. 361-373) edited by Andrew W. Artenstein. New York, United States: Springer. doi: 10.1007/978-1-4419-1108-7_21
Vaccines against human papillomaviruses
Jansen, Kathrin U. and Frazer, Ian H. (2010). Vaccines against human papillomaviruses. New generation vaccines. (pp. 954-961) edited by Myron M. Levine. New York, U.S.A.: Informa Healthcare.
Antigen recognition and self–non-self discrimination
Frazer, Ian H. (2009). Antigen recognition and self–non-self discrimination. Autoimmune neurological disease. (pp. 1-13) edited by Michael P. Pender and Pamela A. McCombe. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/cbo9780511526916.002
Vaccines against human papillomavirus infection
Frazer, Ian H. (2009). Vaccines against human papillomavirus infection. Vaccines against human papillomavirus infection. (pp. 977-986) edited by Levine, M. M. United States: Informa Healthcare.
Vaccines to prevent and treat human papillomavirus associated anogenital disease
Frazer, I.H. and Appleton. S. (2007). Vaccines to prevent and treat human papillomavirus associated anogenital disease. The Cervix. (pp. 609-621) edited by Jordan, J., Singer, A. and et al.. United States: Blackwell publishing. doi: 10.1002/9781444312744.ch44
Development of a Vaccine Against Human Papillomavirus (HPV
Edwards, S. J., Basser, R. L. and Frazer, I. H. (2005). Development of a Vaccine Against Human Papillomavirus (HPV. Vaccines: Frontiers in Design and Development. (pp. 210-230) edited by Philippe Moingeon Stallergenes. United Kingdom: Horizon Bioscience.
Frazer, I. H. (2004). Human Papillomavirus. Vaccines: Preventing Disease & Protecting Health. (pp. 140-143) edited by Ciro A. de Quadros. Washington, D.C.: Pan American Health Organisation.
Vaccines Against Human Papillomavirus Infection
Boslego, J., Liu, X. and Frazer, I. H. (2004). Vaccines Against Human Papillomavirus Infection. New Generation Vaccines. (pp. 977-986) edited by Myron M. Levine, James B. Kaper, Rino Rappuoli, Margaret A. Liu and Michael F. Good. New York: Marcel Dekker, Inc..
Frazer, I. H. (2001). Wart and hepatitis vaccines. Reproductive medicine in the twenty first century. (pp. 173-181) edited by D. L. Healy, R. McLachlan, G. T. Kovacs and O. Rodriguex-Armas. UK: The Parthenon Publishing Group Ltd.
Cell mediated immunity to papillomaviruses
Frazer, I. H. and Tindle, R. (1999). Cell mediated immunity to papillomaviruses. Current research on papillomaviruses. (pp. 151-164) edited by Charles Lacey. Leeds, England: Leeds University Press.
Leggatt, G. R. and Frazer, I. H. (1999). Immunology of HPV infection. Vaccines for Human Papillomavirus Infection and Anogenital Disease. (pp. 13-31) edited by Robert W. Tindle. Austin, USA: R. G. Landes Company.
Frazer, I. H. and Dunn, L. A. (1999). Papillomavirus. Persistent Viral Infections. (pp. 131-146) edited by Rafi Ahmed and Irvin S.Y. Chen. Chichester, USA: John Wiley & Sons.
Safety and Immunogenicity of HPV16 E7/Algammulin
Frazer, I. H., Tindle, R. W., Fernando, G. J., Malcolm, K. M., Herd, K. A., McFadyen, S. M., Cooper, P. D. and Ward, B. G. (1999). Safety and Immunogenicity of HPV16 E7/Algammulin. Vaccines for Human Papillomavirus Infection and Anogenital Disease. (pp. 91-104) edited by R. W. Tindle. Austin, USA: R.G. Landes Company.
Papovaviridiae: capsid structure and capsid protein function
Zhou, J. and Frazer, I. H. (1996). Papovaviridiae: capsid structure and capsid protein function. Papillomavirus reviews: current research on papillomaviruses. (pp. 93-100) edited by Charles Lacey. Leeds, Yorkshire, United Kingdom: Leeds University Press.
Wright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960
Causer, Andrew, Tan, Xiao, Lu, Xuehan, Moseley, Philip, Teoh, Siok M., Molotkov, Natalie, McGrath, Margaret, Kim, Taehyun, Simpson, Peter T, Perry, Christopher, Frazer, Ian H., Panizza, Benedict, Ladwa, Rahul, Nguyen, Quan and Gonzalez-Cruz, Jazmina L. (2023). Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure. n p j Precision Oncology, 7 (1) 89, 89. doi: 10.1038/s41698-023-00444-2
Veitch, Margaret, Beaumont, Kimberly, Pouwer, Rebecca, Chew, Hui Yi, Frazer, Ian H, Soyer, H Peter, Campbell, Scott, Dymock, Brian W, Harvey, Andrew, Cock, Terrie-Anne and Wells, James W (2023). Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts. Journal for ImmunoTherapy of Cancer, 11 (9) e006783, e006783. doi: 10.1136/jitc-2023-006783
Zeng, Bijun, Moi, Davide, Molotkov, Natalie, Tolley, Lynn, Frazer, Ian Hector, Perry, Christopher, Dolcetti, Riccardo, Mazzieri, Roberta and Cruz, Jazmina L. G. (2023). Skin-grafting and dendritic cell “boosted” humanized mouse models allow the pre-clinical evaluation of therapeutic cancer vaccines. Cells, 12 (16) 2094, 1-21. doi: 10.3390/cells12162094
Salivary micro RNAs as biomarkers for oropharyngeal cancer
Ekanayake Weeramange, Chameera, Tang, Kai Dun, Barrero, Roberto A., Hartel, Gunter, Liu, Zhen, Ladwa, Rahul, Langton-Lockton, Julian, Frazer, Ian, Kenny, Lizbeth, Vasani, Sarju and Punyadeera, Chamindie (2023). Salivary micro RNAs as biomarkers for oropharyngeal cancer. Cancer Medicine, 12 (14), 15128-15140. doi: 10.1002/cam4.6185
Bromfield, Jacoba Isobella, Hugenholtz, Philip, Frazer, Ian Hector, Khosrotehrani, Kiarash and Chandra, Janin (2023). Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?. Frontiers in Oncology, 13 1091379, 1091379. doi: 10.3389/fonc.2023.1091379
Mehdi, Ahmed M., Zhou, Chenhao, Turrell, Gavin, Walpole, Euan, Porceddu, Sandro, Frazer, Ian H. and Chandra, Janin (2022). HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer. Cancer Gene Therapy, 30 (4), 1-12. doi: 10.1038/s41417-022-00577-9
Sinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150
Muralidharan, Sachin, Ali, Sarah, Yang, Lilin, Badshah, Joshua, Zahir, Syeda Farah, Ali, Rubbiya A., Chandra, Janin, Frazer, Ian H., Thomas, Ranjeny and Mehdi, Ahmed M. (2022). Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associations. Scientific Reports, 12 (1) 18710, 1-19. doi: 10.1038/s41598-022-21988-6
Yang, Xiaodan, Liu, Xiaosong, Li, Junjie, Zhang, Pingping, Li, Hejie, Chen, Guoqiang, Zhang, Wei, Wang, Tianfang, Frazer, Ian and Ni, Guoying (2022). Caerin 1.1/1.9 enhances antitumour immunity by activating the IFN-α response signalling pathway of tumour macrophages. Cancers, 14 (23) 5785, 1-22. doi: 10.3390/cancers14235785
Tran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873
Schiller, John T., Lowy, Douglas R., Frazer, Ian H., Finn, Olivera J., Vilar, Eduardo, Lyerly, H. Kim, Gnjatic, Sacha, Zaidi, Neeha, Ott, Patrick A., Balachandran, Vinod P., Dietrich, Pierre-Yves, Migliorini, Denis, Vonderheide, Robert H. and Domchek, Susan M. (2022). Cancer vaccines. Cancer Cell, 40 (6), 559-564. doi: 10.1016/j.ccell.2022.05.015
Krueger, Annika, Mohamed, Ahmed, Kolka, Cathryn M., Stoll, Thomas, Zaugg, Julian, Linedale, Richard, Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip, Frazer, Ian H. and Hill, Michelle M. (2022). Skin cancer-associated S. aureus strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stress. Cancers, 14 (9) 2143. doi: 10.3390/cancers14092143
Ekanayake Weeramange, Chameera, Shu, Danhua, Tang, Kai Dun, Batra, Jyotsna, Ladwa, Rahul, Kenny, Lizbeth, Vasani, Sarju, Frazer, Ian H., Dolcetti, Riccardo, Ellis, Jonathan J., Sturm, Richard A., Leo, Paul and Punyadeera, Chamindie (2022). Analysis of human leukocyte antigen associations in human papillomavirus–positive and –negative head and neck cancer: Comparison with cervical cancer. Cancer, 128 (10), 1937-1947. doi: 10.1002/cncr.34148
Changes in the skin microbiome associated with squamous cell carcinoma in transplant recipients
Krueger, Annika, Zaugg, Julian, Lachner, Nancy, Bialasiewicz, Seweryn, Lin, Lynlee L., Gabizon, Sharon, Sobarun, Priyamvada, Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip and Frazer, Ian H. (2022). Changes in the skin microbiome associated with squamous cell carcinoma in transplant recipients. ISME Communications, 2 (1) 13, 13. doi: 10.1038/s43705-022-00095-7
Krueger, Annika, Zaugg, Julian, Chisholm, Sarah, Linedale, Richard, Lachner, Nancy, Teoh, Siok Min, Tuong, Zewen K., Lukowski, Samuel W., Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip, Hill, Michelle M. and Frazer, Ian H. (2022). Secreted toxins from Staphylococcus aureus strains isolated from keratinocyte skin cancers mediate pro-tumorigenic inflammatory responses in the skin. Frontiers in Microbiology, 12 789042, 789042. doi: 10.3389/fmicb.2021.789042
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?
Quang, Chau, Chung, Amy W., Frazer, Ian H., Toh, Zheng Quan and Licciardi, Paul V. (2022). Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?. Trends in Immunology, 43 (10), 815-825. doi: 10.1016/j.it.2022.07.011
Rødahl, Inga, Gotley, James, Andersen, Stacey B., Yu, Meihua, Mehdi, Ahmed M., Christ, Angelika N., Hamilton-Williams, Emma E., Frazer, Ian H., Lukowski, Samuel W. and Chandra, Janin (2021). Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq. STAR Protocols, 2 (4) 100842, 1-27. doi: 10.1016/j.xpro.2021.100842
A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia
Tuong, Zewen K., Lukowski, Samuel W., Nguyen, Quan H., Chandra, Janin, Zhou, Chenhao, Gillinder, Kevin, Bashaw, Abate A., Ferdinand, John R., Stewart, Benjamin J., Teoh, Siok Min, Hanson, Sarah J., Devitt, Katharina, Clatworthy, Menna R., Powell, Joseph E. and Frazer, Ian H. (2021). A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia. iScience, 24 (11) 103326, 103326. doi: 10.1016/j.isci.2021.103326
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers
Begley, C. Glenn, Ashton, Mark, Baell, Jonathan, Bettess, Michael, Brown, Michael P., Carter, Brett, Charman, William N., Davis, Christopher, Fisher, Simon, Frazer, Ian, Gautam, Anand, Jennings, Michael P., Kearney, Philip, Keeffe, Eloise, Kelly, Darren, Lopez, Angel F., McGuckin, Michael, Parker, Michael W., Rayner, Craig, Roberts, Brett, Rush, James S. and Sullivan, Mark (2021). Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers. Science Translational Medicine, 13 (612) eabd5524, eabd5524. doi: 10.1126/scitranslmed.abd5524
Ni, Guoying, Yang, Xiaodan, Li, Junjie, Wu, Xiaolian, Liu, Ying, Li, Hejie, Chen, Shu, Fogarty, Conor E., Frazer, Ian H., Chen, Guoqiang, Liu, Xiaosong and Wang, Tianfang (2021). Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC‐1 tumor‐bearing mice with PD‐1 blockade by modulating macrophage heterogeneity and the activation of CD8+ T cells in the tumor microenvironment. Clinical and Translational Immunology, 10 (8) e1335, 1-25. doi: 10.1002/cti2.1335
Ekanayake Weeramange, Chameera, Liu, Zhen, Hartel, Gunter, Li, Yinan, Vasani, Sarju, Langton-Lockton, Julian, Kenny, Lizbeth, Morris, Luc, Frazer, Ian, Tang, Kai Dun and Punyadeera, Chamindie (2021). Salivary high-risk human papillomavirus DNA as a biomarker for human papillomavirus–driven head and neck cancers. The Journal of Molecular Diagnostics, 23 (10), 1334-1342. doi: 10.1016/j.jmoldx.2021.07.005
Scheffer, Ingrid E. and Frazer, Ian H. (2021). The Australian Academy of Health and Medical Sciences: an authoritative, independent voice in the Australian landscape. Medical Journal of Australia, 214 (11), 502-504.e1. doi: 10.5694/mja2.51089
Evolution of cancer vaccines—challenges, achievements and future directions
Tay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535
Zeng, Zhen, Veitch, Margaret, Kelly, Gabrielle A., Tuong, Zewen K., Cruz, Jazmina G., Frazer, Ian H. and Wells, James W. (2021). IFN-γ critically enables the intratumoural infiltration of CXCR3+ CD8+ T cells to drive squamous cell carcinoma regression. Cancers, 13 (9) 2131, 2131. doi: 10.3390/cancers13092131
Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration
Bastow, Cameron R., Bunting, Mark D., Kara, Ervin E., McKenzie, Duncan R., Caon, Adriana, Devi, Sapna, Tolley, Lynn, Mueller, Scott N., Frazer, Ian H., Harvey, Natasha, Condina, Mark R., Young, Clifford, Hoffmann, Peter, McColl, Shaun R. and Comerford, Iain (2021). Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Proceedings of the National Academy of Sciences, 118 (17) e2025763118, 1-9. doi: 10.1073/pnas.2025763118
Lukowski, Samuel W., Rodahl, Inga, Kelly, Samuel, Yu, Meihua, Gotley, James, Zhou, Chenhao, Millard, Susan, Andersen, Stacey B., Christ, Angelika N., Belz, Gabrielle, Frazer, Ian H. and Chandra, Janin (2021). Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells. iScience, 24 (5) 102402, 1-21. doi: 10.1016/j.isci.2021.102402
An update on cervical cancer screening in Vanuatu
Allanson, Emma R., Velanova, Vera, Frazer, Ian H. and McAdam, Margaret (2021). An update on cervical cancer screening in Vanuatu. International Journal of Gynecological Cancer, 31 (4), 631-632. doi: 10.1136/ijgc-2020-002129
Budhwani, Megha, Turrell, Gavin, Yu, Meihua, Frazer, Ian H., Mehdi, Ahmed M. and Chandra, Janin (2021). Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients. Frontiers in Molecular Biosciences, 8 622643, 622643. doi: 10.3389/fmolb.2021.622643
Editorial: Immunology of HPV infection and vaccination: progress and challenges
Licciardi, Paul V., Frazer, Ian H., Garland, Suzanne M. and Mulholland, Kim (2021). Editorial: Immunology of HPV infection and vaccination: progress and challenges. Frontiers in Immunology, 12 665463, 665463. doi: 10.3389/fimmu.2021.665463
Zhou, Chenhao, Tuong, Zewen Kelvin, Lukowski, Samuel Wieslaw, Chandra, Janin and Frazer, Ian H. (2021). Antigen nonspecific induction of distinct regulatory T cell states in oncogene-driven hyperproliferative skin. ImmunoHorizons, 5 (2), 102-116. doi: 10.4049/immunohorizons.2100006
Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy
Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355
Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium
Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011
Measurement of human papillomavirus-specific antibodies using a pseudovirion-based ELISA method
Toh, Zheng Quan, He, Laura, Chen, Catherine, Huang, Angela, Russell, Fiona M., Garland, Suzanne M., Reyburn, Rita, Ratu, Tupou, Tuivaga, Evelyn, Frazer, Ian H., Mulholland, E. Kim and Licciardi, Paul V. (2020). Measurement of human papillomavirus-specific antibodies using a pseudovirion-based ELISA method. Frontiers in Immunology, 11 585768, 1-9. doi: 10.3389/fimmu.2020.585768
Chandra, J., Woo, W. P., Finlayson, N., Liu, H. Y., McGrath, M., Ladwa, R., Brauer, M., Xu, Y., Hanson, S., Panizza, B., Frazer, I. H. and Porceddu, Sandro V. (2020). A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC). Cancer Immunology, Immunotherapy, 70 (3), 743-753. doi: 10.1007/s00262-020-02720-7
Oral HPV16 DNA as a screening tool to detect early oropharyngeal squamous cell carcinoma
Tang, Kai D., Vasani, Sarju, Menezes, Lilian, Taheri, Touraj, Walsh, Laurence J., Hughes, Brett G.M., Frazer, Ian H., Kenny, Liz, Scheper, Gert C. and Punyadeera, Chamindie (2020). Oral HPV16 DNA as a screening tool to detect early oropharyngeal squamous cell carcinoma. Cancer Science, 111 (10) cas.14585, 3854-3861. doi: 10.1111/cas.14585
Budhwani, Megha, Lukowski, Samuel W., Porceddu, Sandro V., Frazer, Ian H. and Chandra, Janin (2020). Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets. Frontiers in Cellular and Infection Microbiology, 10 307, 307. doi: 10.3389/fcimb.2020.00307
Collaboration in the war against viruses: a multidisciplinary international effort
Frazer, Ian H. (2020). Collaboration in the war against viruses: a multidisciplinary international effort. The Innovation, 1 (1) 100011, 100011. doi: 10.1016/j.xinn.2020.04.011
The Innovation: A Journal to See the Unseen and Change the Unchanged
Chen, Ke, Huang, Tao, Liu, Enke, Lu, Yuyuan, Huo, Zhigang, Mi, Lei, Zhang, Wei and Frazer, Ian (2020). The Innovation: A Journal to See the Unseen and Change the Unchanged. Innovation(China), 1 (1) 100014, 1-2. doi: 10.1016/j.xinn.2020.04.014
Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019
Krueger, Annika, Stoll, Thomas, Shah, Alok K., Sinha, Rohit, Frazer, Ian H. and Hill, Michelle M. (2020). Antibody-free multiplex measurement of 23 human cytokines in primary cell culture secretome using targeted mass spectrometry. Analytical Chemistry, 92 (5), 3742-3750. doi: 10.1021/acs.analchem.9b05028
Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers
Tang, Kai Dun, Menezes, Lilian, Baeten, Kurt, Walsh, Laurence J., Whitfield, Bernard C. S., Batstone, Martin D., Kenny, Liz, Frazer, Ian H., Scheper, Gert C. and Punyadeera, Chamindie (2020). Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers. Biomolecules, 10 (2) 223, 223. doi: 10.3390/biom10020223
Huang, Kunsong, Ni, Guoying, Ma, Bowei, Chen, Shu, Luan, Yi, Wang, Tianfang, Walton, Shelley, Frazer, Ian, Liu, Xiaosong and Pan, Xuan (2020). Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China. The Journal of International Medical Research, 48 (1), 1-13. doi: 10.1177/0300060519897187
Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M. and Frazer, Ian H. (2019). Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial. PLoS One, 14 (12) e0226320, 1-20. doi: 10.1371/journal.pone.0226320
Acute exercise does not improve immune response to HPV vaccination series in adolescents
Bohn-Goldbaum, E., Lee, Vivian Y., Skinner, S. Rachel, Frazer, I. H., Khan, Burhan A., Booy, Robert and Edwards, Kate M. (2019). Acute exercise does not improve immune response to HPV vaccination series in adolescents. Papillomavirus Research, 8 100178, 100178. doi: 10.1016/j.pvr.2019.100178
Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0
Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162
Immunotherapy for HPV associated cancer
Frazer, Ian H. and Chandra, Janin (2019). Immunotherapy for HPV associated cancer. Papillomavirus Research, 8 100176, 100176. doi: 10.1016/j.pvr.2019.100176
Toh, Zheng Quan, Kosasih, Jennie, Russell, Fiona M., Reyburn, Rita, Fong, James, Tuivaga, Evelyn, Ratu, Felisita T., Nguyen, Cattram D., Matanitobua, Silivia, Do, Lien Anh Ha, Menheniott, Trevelyan, Frazer, Ian H., Garland, Suzanne M., Mulholland, Edward Kim and Licciardi, Paul V. (2019). Selective persistence of HPV cross-neutralising antibodies following reduced-dose HPV vaccine schedules. Vaccines, 7 (4) 200, 200. doi: 10.3390/vaccines7040200
Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions
Devitt, Katharina, Hanson, Sarah J., Tuong, Zewen K., McMeniman, Erin, Soyer, H. Peter, Frazer, Ian H. and Lukowski, Samuel W. (2019). Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions. Virology, 537, 14-19. doi: 10.1016/j.virol.2019.08.007
Ng, Hwee-Ing, Tuong, Zewen K., Fernando, Germain J. P., Depelsenaire, Alexandra C. I., Meliga, Stefano C., Frazer, Ian H. and Kendall, Mark A. F. (2019). Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses. npj Vaccines, 4 (1) 41, 41. doi: 10.1038/s41541-019-0134-4
Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
Ni, Guoying, Huang, Kunsong, Luan, Yi, Cao, Zaizai, Chen, Shu, Ma, Bowei, Yuan, Jianwei, Wu, Xiaolian, Chen, Guoqiang, Wang, Tianfang, Li, Hejie, Walton, Shelley, Liu, Fang, Chen, Bobei, Wang, Yuejian, Pan, Xuan, Liu, Xiaosong and Frazer, Ian H. (2019). Human papillomavirus infection among head and neck squamous cell carcinomas in southern China. PLoS ONE, 14 (9) e0221045, e0221045. doi: 10.1371/journal.pone.0221045
Papillomavirus immune evasion strategies target the infected cell and the local immune system
Zhou, Chenhao, Tuong, Zewen Kelvin and Frazer, Ian Hector (2019). Papillomavirus immune evasion strategies target the infected cell and the local immune system. Frontiers in Oncology, 9 682, 682. doi: 10.3389/fonc.2019.00682
Frazer, Ian H. (2019). The HPV vaccine story. ACS Pharmacology and Translational Science, 2 (3) acsptsci.9b00032, 210-212. doi: 10.1021/acsptsci.9b00032
Tang, Kai Dun, Kenny, Liz, Frazer, Ian H. and Punyadeera, Chamindie (2019). High-risk human papillomavirus detection in oropharyngeal cancers: comparison of saliva sampling methods. Head and Neck, 41 (5), 1484-1489. doi: 10.1002/hed.25578
Unlocking the potential of saliva-based test to detect HPV-16-driven oropharyngeal cancer
Tang, Kai Dun, Baeten, Kurt, Kenny, Liz, Frazer, Ian H., Scheper, Gert and Punyadeera, Chamindie (2019). Unlocking the potential of saliva-based test to detect HPV-16-driven oropharyngeal cancer. Cancers, 11 (4) 473, 473. doi: 10.3390/cancers11040473
Velentzis, Louiza S., Smith, Megan A., Simms, Kate T., Lew, Jie-Bin, Hall, Michaela, Hughes, Suzanne, Yuill, Susan, Killen, James, Keane, Adam, Butler, Katherine, Darlington-Brown, Jessica, Hui, Harriet, Brotherton, Julia M.L., Skinner, Rachel, Brand, Alison, Roeske, Lara, Heley, Stella, Carter, Jonathan, Bateson, Deborah, Frazer, Ian, Garland, Suzanne M., Guy, Rebecca, Hammond, Ian, Grogan, Paul, Arbyn, Marc, Castle, Philip E., Saville, Marion, Armstrong, Bruce K. and Canfell, Karen (2019). Pathways to a cancer-free future: a protocol for modelled evaluations to maximize the future impact of interventions on cervical cancer in Australia. Gynecologic Oncology, 152 (3), 465-471. doi: 10.1016/j.ygyno.2018.12.019
Kuo, Paula, Teoh, Siok Min, Tuong, Zewen K., Leggatt, Graham R., Mattarollo, Stephen R. and Frazer, Ian H. (2018). Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction. Frontiers in Immunology, 9 2896, 2896. doi: 10.3389/fimmu.2018.02896
HLA and KIR associations of cervical neoplasia
Bao, Xiao, Hanson, Aimee L., Madeleine, Margaret M., Wang, Sophia S., Schwartz, Stephen M., Newell, Felicity, Pettersson-Kymmer, Ulrika, Hemminki, Kari, Tiews, Sven, Steinberg, Winfried, Rader, Janet S., Castro, Felipe, Safaeian, Mahboobeh, Franco, Eduardo L., Coutlée, François, Ohlsson, Claes, Cortes, Adrian, Marshall, Mhairi, Mukhopadhyay, Pamela, Cremin, Katie, Johnson, Lisa G., Garland, Suzanne M., Tabrizi, Sepehr N., Wentzensen, Nicolas, Sitas, Freddy, Trimble, Cornelia, Little, Julian, Cruickshank, Maggie, Frazer, Ian H. ... Leo, Paul J. (2018). HLA and KIR associations of cervical neoplasia. The Journal of Infectious Diseases, 218 (12), 2006-2015. doi: 10.1093/infdis/jiy483
Zammit, Andrew P., Sinha, Rohit, Cooper, Caroline L., Perry, Christopher F. L., Frazer, Ian H. and Tuong, Zewen K. (2018). Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: a prospective observational study. PLoS One, 13 (10) e0205406, e0205406. doi: 10.1371/journal.pone.0205406
A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes
Wood, David L. A., Lachner, Nancy, Tan, Jean-Marie, Tang, Stephanie, Angel, Nicola, Laino, Antonia, Linedale, Richard, Lê Cao, Kim-Anh, Morrison, Mark, Frazer, Ian H., Soyer, H. Peter and Hugenholtz, Philip (2018). A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes. MBio, 9 (5) e01432-18. doi: 10.1128/mBio.01432-18
The projected timeframe until cervical cancer elimination in Australia: a modelling study
Hall, Michaela T., Simms, Kate T., Lew, Jie-Bin, Smith, Megan A., Brotherton, Julia M. l., Saville, Marion, Frazer, Ian H. and Canfell, Karen (2018). The projected timeframe until cervical cancer elimination in Australia: a modelling study. The Lancet. Public health, 4 (1), e19-e27. doi: 10.1016/S2468-2667(18)30183-X
Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190
Jung, Ji-Won, Veitch, Margaret, Bridge, Jennifer A., Overgaard, Nana H., Cruz, Jazmina L., Linedale, Richard, Franklin, Michael E., Saunders, Nicholas A., Simpson, Fiona, Frazer, Ian H., Steptoe, Raymond J. and Wells, James W. (2018). Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma. OncoImmunology, 7 (9) e1479627, 1-16. doi: 10.1080/2162402X.2018.1479627
Detection of HPV E7 transcription at single-cell resolution in epidermis
Lukowski, S. W., Tuong, Z. K., Noske, K., Senabouth, A., Nguyen, Q. H., Andersen, S. B., Soyer, H. P., Frazer, I. H. and Powell, J. E. (2018). Detection of HPV E7 transcription at single-cell resolution in epidermis. The Journal of Investigative Dermatology, 138 (12), 2558-2567. doi: 10.1016/j.jid.2018.06.169
Fernando, Germain J. P., Hickling, Julian, Jayashi Flores, Cesar M., Griffin, Paul, Anderson, Christopher D., Skinner, S. Rachel, Davies, Cristyn, Witham, Katey, Pryor, Melinda, Bodle, Jesse, Rockman, Steve, Frazer, Ian H. and Forster, Angus H. (2018). Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™). Vaccine, 36 (26), 3779-3788. doi: 10.1016/j.vaccine.2018.05.053
HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin
Kuo, Paula, Tuong, Zewen K, Teoh, Siok Min, Frazer, Ian H, Mattarollo, Stephen and Leggatt, Graham R (2018). HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin. The Journal of investigative dermatology, 138 (6), 1348-1359. doi: 10.1016/j.jid.2017.12.021
No vacillation on HPV vaccination
Sipp, Douglas, Frazer, Ian H. and Rasko, John E. J. (2018). No vacillation on HPV vaccination. Cell, 172 (6), 1163-1167. doi: 10.1016/j.cell.2018.02.045
Leo, Paul J., Madeleine, Margaret M., Wang, Sophia, Schwartz, Stephen M., Newell, Felicity, Pettersson-Kymmer, Ulrika, Hemminki, Kari, Hallmans, Goran, Tiews, Sven, Steinberg, Winfried, Rader, Janet S., Castro, Felipe, Safaeian, Mahboobeh, Franco, Eduardo L., Coutlée, François, Ohlsson, Claes, Cortes, Adrian, Marshall, Mhairi, Mukhopadhyay, Pamela, Cremin, Katie, Johnson, Lisa G., Trimble, Cornelia L., Garland, Suzanne, Tabrizi, Sepehr N., Wentzensen, Nicolas, Sitas, Freddy, Little, Julian, Cruickshank, Maggie, Frazer, Ian H. ... Brown, Matthew A. (2018). Correction: Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study. PLoS Genetics, 14 (3) e1007257. doi: 10.1371/JOURNAL.PGEN.1007257
Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full…
Frazer, Ian H. (2018). Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full…. Viral Immunology, 31 (2), 1-6. doi: 10.1089/vim.2017.0119
Foreword medicine, health and being human
Frazer, Ian (2018). Foreword medicine, health and being human. Medicine, Health and Being Human, XVI-XVI.
Bhat, Purnima, Bergot, Anne-Sophie, Waterhouse, Nigel and Frazer, Ian Hector (2017). Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells. Oncotarget, 9 (5), 6015-6027. doi: 10.18632/oncotarget.23210
Chakraborty, Rituparna, Chandra, Janin, Cui, Shuai, Tolley, Lynn, Cooper, Matthew A., Kendall, Mark and Frazer, Ian H. (2017). CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. Experimental Dermatology, 27 (1), 71-79. doi: 10.1111/exd.13436
Modulation of antigen presenting cell functions during chronic HPV infection
Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002
Tuong, Z. K., Noske, K., Kuo, P., Bashaw, A. A., Teoh, S. M. and Frazer, I. H. (2017). Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions. Papillomavirus Research, 5, 6-20. doi: 10.1016/j.pvr.2017.10.001
Tang, Kai Dun, Kenny, Liz, Perry, Chris, Frazer, Ian and Punyadeera, Chamindie (2017). The overexpression of salivary cytokeratins as potential diagnostic biomarkers in head and neck squamous cell carcinomas. Oncotarget, 8 (42), 72272-72280. doi: 10.18632/oncotarget.19731
Hoang, Van L. T., Tom, Lisa N., Quek, Xiu-Cheng, Tan, Jean-Marie, Payne, Elizabeth J., Lin, Lynlee L., Sinnya, Sudipta, Raphael, Anthony P., Lambie, Duncan, Frazer, Ian H., Dinger, Marcel E., Soyer, H. Peter and Prow, Tarl W. (2017). RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers. Peerj, 2017 (8) 3631, e3631. doi: 10.7717/peerj.3631
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study
Leo, Paul J., Madeleine, Margaret M., Wang, Sophia, Schwartz, Stephen M., Newell, Felicity, Pettersson-Kymmer, Ulrika, Hemminki, Kari, Hallmans, Goran, Tiews, Sven, Steinberg, Winfried, Rader, Janet S., Castro, Felipe, Safaeian, Mahboobeh, Franco, Eduardo L., Coutlee, Francois, Ohlsson, Claes, Cortes, Adrian, Marshall, Mhairi, Mukhopadhyay, Pamela, Cremin, Katie, Johnson, Lisa G., Garland, Suzanne, Tabrizi, Sepehr N., Wentzensen, Nicolas, Sitas, Freddy, Little, Julian, Cruickshank, Maggie, Frazer, Ian H., Hildesheim, Allan and Brown, Matthew A. (2017). Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study. Plos Genetics, 13 (8) e1006866, e1006866. doi: 10.1371/journal.pgen.1006866
Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R
Bhat, Purnima, Leggatt, Graham, Waterhouse, Nigel and Frazer, Ian H. (2017). Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death and Disease, 8 (6) e2836, e2836.1-e2836.11. doi: 10.1038/cddis.2017.67
HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts
Jazayeri, Seyed D., Kuo, Paula, Leggatt, Graham R. and Frazer, Ian (2017). HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts. Frontiers in Immunology, 8 (MAY) 524, 524. doi: 10.3389/fimmu.2017.00524
Clinical development strategy for a candidate group A streptococcal vaccine
Schödel, Florian, Moreland, Nicole J., Wittes, Janet T., Mulholland, Kim, Frazer, Ian, Steer, Andrew C., Fraser, John D. and Carapetis, Jonathan (2017). Clinical development strategy for a candidate group A streptococcal vaccine. Vaccine, 35 (16), 2007-2014. doi: 10.1016/j.vaccine.2017.02.060
Toh, Zheng Quan, Russell, Fiona M., Reyburn, Rita, Fong, James, Tuivaga, Evelyn, Ratu, Tupou, Nguyen, Cattram D., Devi, Rachel, Kama, Mike, Matanitobua, Silivia, Tabrizi, Sepehr N., Garland, Suzanne M., Sinha, Rohit, Frazer, Ian, Tikoduadua, Lisi, Kado, Joseph, Rafai, Eric, Mulholland, Edward K. and Licciardi, Paul V. (2017). Sustained antibody responses 6 years following 1, 2, or 3 doses of quadrivalent Human Papillomavirus (HPV) vaccine in adolescent Fijian girls, and subsequent responses to a single dose of bivalent HPV vaccine: a prospective cohort study. Clinical Infectious Diseases, 64 (7), 852-859. doi: 10.1093/cid/ciw865
A pilot study into the association between oral health status and human papillomavirus-16 infection
Sun, Charles Xiaohang, Bennett, Nigel, Tran, Peter, Tang, Kai Dun, Lim, Yenkai, Frazer, Ian, Samaranayake, Lakshman and Punyadeera, Chamindie (2017). A pilot study into the association between oral health status and human papillomavirus-16 infection. Diagnostics, 7 (1) 11, 11. doi: 10.3390/diagnostics7010011
Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156
Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function
Chandra, Janin, Kuo, Paula T. Y., Hahn, Anne M., Belz, Gabrielle T. and Frazer, Ian H. (2016). Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunology and Cell Biology, 95 (2), 215-223. doi: 10.1038/icb.2016.83
Dutton, Julie L., Woo, Wai-Ping, Chandra, Janin, Xu, Yan, Li, Bo, Finlayson, Neil, Griffin, Paul and Frazer, Ian H. (2016). An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines and Immunotherapeutics, 12 (12), 3079-3088. doi: 10.1080/21645515.2016.1221872
Zhussupbekova, Samal, Sinha, Rohit, Kuo, Paula, Lambert, Paul F., Frazer, Ian H. and Tuong, Zewen K. (2016). A mouse model of hyperproliferative human epithelium validated by keratin profiling ahows an aberrant cytoskeletal response to injury. Ebiomedicine, 9, 314-323. doi: 10.1016/j.ebiom.2016.06.011
Role of ultraviolet radiation in papillomavirus-induced disease
Uberoi, Aayushi, Yoshida, Satoshi, Frazer, Ian H., Pitot, Henry C. and Lambert, Paul F. (2016). Role of ultraviolet radiation in papillomavirus-induced disease. PLoS Pathogens, 12 (5) e1005664, e1005664. doi: 10.1371/journal.ppat.1005664
Chandra, Janin, Miao, Yan, Romoff, Natasha and Frazer, Ian H. (2016). Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity. Plos One, 11 (3) e0152886, e0152886. doi: 10.1371/journal.pone.0152886
Chai, Ryan C., Lim, Yenkai, Frazer, Ian H., Wan, Yunxia, Perry, Christopher, Jones, Lee, Lambie, Duncan and Punyadeera, Chamindie (2016). A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16(INK4a) expression in head and neck squamous cell carcinoma patients. Bmc Cancer, 16 (1) 178, 178. doi: 10.1186/s12885-016-2217-1
Tran, Le Son, Mittal, Deepak, Mattarollo, Stephen R. and Frazer, Ian H. (2015). Interleukin-17A promotes arginase-1 production and 2,4-dinitrochlorobenzene-induced acute hyperinflammation in human papillomavirus E7 oncoprotein-expressing skin. Journal of Innate Immunity, 7 (4), 392-404. doi: 10.1159/000374115
Abd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R., Mattarollo, Stephen R., Frazer, Ian H. and Hibma, Merilyn H. (2015). Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS One, 10 (5) e0127155, e0127155-e0127155. doi: 10.1371/journal.pone.0127155
Jung, Ji-Won, Overgaard, Nana H., Burke, Michael T., Isbel, Nicole, Frazer, Ian H., Simpson, Fiona and Wells, James W. (2015). Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?. International Journal of Cancer, 138 (2), 281-292. doi: 10.1002/ijc.29450
Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015). HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 (6), 540-547. doi: 10.1038/icb.2014.123
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
Apetoh, Lionel, Smyth, Mark J., Drake, Charles G., Abastado, Jean-Pierre, Apte, Ron N., Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H., Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P., Comin-Anduix, Begona, Coukos, Georges, Dhodapkar, Madhav V., Dranoff, Glenn, Frazer, Ian H., Fridman, Wolf-Herve, Gabrilovich, Dmitry I., Gilboa, Eli, Gnjatic, Sacha, Jaeger, Dirk, Kalinski, Pawel, Kaufman, Howard L., Kiessling, Rolf, Kirkwood, John ... Anderson, Ana C. (2015). Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology, 4 (4), e998538-1-e998538-10. doi: 10.1080/2162402X.2014.998538
Human papillomavirus 18 genetic variation and cervical cancer risk worldwide
Chen, Alyce A., Gheit, Tarik, Franceschi, Silvia, Tommasino, Massimo, Clifford, Gary M., the IARC HPV Variant Study Group, Herrero, R., Bosch, X., Hammouda, D., Loria, D., Matos, E., Tshomo, U., Rios-Dalenz, J. L., Eluf-Neto, J., Ghadirian, P., Ferreccio, C., Ojeda, J. M., Dai, M., Li, L. K., Wu, R. F., Torroella, M., Pearce, N., Alibegashvili, T., Kordzaia, D., Keita, N., Koulibaly, M., Rajkumar, T., Rajkumar, R., Sarjadi, ... Frazer, I. H. (2015). Human papillomavirus 18 genetic variation and cervical cancer risk worldwide. Journal of Virology, 89 (20), 10680-10687. doi: 10.1128/JVI.01747-15
The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?
Frazer, I. H. (2015). The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?. Current Problems in Dermatology (Switzerland), 46, 28-35. doi: 10.1159/000366532
Microprojection arrays to immunise at mucosal surfaces
McNeilly, Celia L., Crichton, Michael L., Primiero, Clare A., Frazer, Ian H., Roberts, Michael S. and Kendall, Mark A. F. (2014). Microprojection arrays to immunise at mucosal surfaces. Journal of Controlled Release, 196, 252-260. doi: 10.1016/j.jconrel.2014.09.028
Velentzis, Louiza S., Sitas, Freddy, O'Connell, Dianne L., Darlington-Brown, Jessica, Egger, Sam, Sinha, Rohit, Banks, Emily, Frazer, Ian H. and Canfell, Karen (2014). Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study. BMC Infectious Diseases, 14 (3861) 3861, 1-10. doi: 10.1186/s12879-014-0676-z
Freeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10), 1-11. doi: 10.1371/journal.ppat.1004466
CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array
Haigh, Oscar, Depelsenaire, Alexandra C. I., Meliga, Stefano C., Yukiko, Sally R., McMillan, Nigel A. J., Frazer, Ian H. and Kendall, Mark A. F. (2014). CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array. Journal of Controlled Release, 194, 148-156. doi: 10.1016/j.jconrel.2014.08.021
Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity
Depelsenaire, Alexandra C. I., Meliga, Stefano C., McNeilly, Celia, Pearson, Frances E., Coffey, Jacob, Haigh, Oscar L., Flaim, Christopher J., Frazer, Ian H. and Kendall, Mark A. F. (2014). Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity. The Journal of Investigative Dermatology, 134 (9), 2361-2370. doi: 10.1038/jid.2014.174
IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia
Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216
Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381
Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014). IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 (10), 2562-2569. doi: 10.1038/jid.2014.201
Development and implementation of papillomavirus prophylactic vaccines
Frazer, Ian H. (2014). Development and implementation of papillomavirus prophylactic vaccines. Journal of Immunology, 192 (9), 4007-4011. doi: 10.4049/jimmunol.1490012
The kinematics of cytotoxic lymphocytes influence their ability to kill target cells
Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248
Tran, Le Son, Bergot, Anne-Sophie, Mattarollo, Stephen R., Mittal, Deepak and Frazer, Ian H. (2014). Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism. Journal of Investigative Dermatology, 134 (9), 2438-2446. doi: 10.1038/jid.2014.186
Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959
Wikstrom, Matthew E., Khong, Andrea, Fleming, Peter, Kuns, Rachel, Hertzog, Paul J., Frazer, Ian H., Andoniou, Christopher E., Hill, Geoffrey R. and Degli-Esposti, Mariapia A. (2014). The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals. European Journal of Immunology, 44 (2), 409-419. doi: 10.1002/eji.201243109
Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Marshak, Joshua O., Xu, Yan, Huang, Meei-Li, Dong, Lichun, Frazer, Ian H. and Koelle, David M. (2013). A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice. PloS One, 8 (10) e76407, e76407.1-e76407.9. doi: 10.1371/journal.pone.0076407
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes
Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R., Liem, Amy, Lambert, Paul F., Frazer, Ian H. and Leggatt, Graham R. (2013). Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One, 8 (2) e57798, e57798.1-e57798.8. doi: 10.1371/journal.pone.0057798
A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin
Fiorenza, Salvatore, Kenna, Tony J., Comerford, Iain, McColl, Shaun, Steptoe, Raymond J., Leggatt, Graham R. and Frazer, Ian H. (2012). A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin. Journal of Immunology, 189 (12), 5622-5631. doi: 10.4049/jimmunol.1200709
Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice
Heng, Tracy S. P., Reiseger, Jessica J., Fletcher, Anne L., Leggatt, Graham R., White, Olivia J., Vlahos, Katerina, Frazer, Ian H., Turner, Stephen J. and Boyd, Richard L. (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS One, 7 (8) e42677, e42677.1-e42677.11. doi: 10.1371/journal.pone.0042677
Rahimpour, Azad, Mattarollo, Stephen R., Yong, Michelle, Leggatt, Graham R., Steptoe, Raymond J. and Frazer, Ian H. (2012). gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. Journal of Investigative Dermatology, 132 (6), 1656-1664. doi: 10.1038/jid.2012.16
A randomized trial of immunotherapy for persistent genital warts
Jardine, David, Lu, Jieqiang, Pang, James, Palmer, Cheryn, Tu, Quanmei, Chuah, John and Frazer, Ian H. (2012). A randomized trial of immunotherapy for persistent genital warts. Human Vaccines and Immunotherapeutics, 8 (5), 623-629. doi: 10.4161/hv.19319
Prevalence of cervical Human Papillomavirus (HPV) infection in Vanuatu
Aruhuri, Bernadette, Tarivonda, Len, Tenet, Vanessa, Sinha, Rohit, Snijders, Peter J. F., Clifford, Gary, Pang, James, McAdam, Margaret, Meijer, Chris J. L. M., Frazer, Ian H. and Franceschi, Silvia (2012). Prevalence of cervical Human Papillomavirus (HPV) infection in Vanuatu. Cancer Prevention Research, 5 (5), 746-753. doi: 10.1158/1940-6207.CAPR-11-0515
Fernando, Germain J. P., Chen, Xianfeng, Primero, Clare A., Yukiko, Sally R., Fairmaid, Emily J., Corbett, Holly J., Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2012). Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses. Journal of Controlled Release, 159 (2), 215-221. doi: 10.1016/j.jconrel.2012.01.030
Martin, Jennifer H., Thelle, David E., Ho, Ken K. Y. and Frazer, Ian H. (2012). Diamantina Health Partners: Integrating leadership in research, research translation, education and clinical care. Medical Journal of Australia, 196 (4), 237-239. doi: 10.5694/mja11.11251
Chen, Xianfeng, Fernando, Germain J. P., Raphael, Anthony P., Yukiko, Sally R., Fairmaid, Emily J., Primiero, Clare A., Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2012). Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin. Journal of Controlled Release, 158 (1), 78-84. doi: 10.1016/j.jconrel.2011.10.026
Mattarollo, Stephen R. and Frazer, Ian H. (2012). Response to Comment on "Invariant NKT Cells in Hyperplastic Skin Induced a Local Immune Suppressive Environment by IFN-gamma Production". Journal of Immunology, 188 (3), 931-932. doi: 10.4049/jimmunol.1190089
New gene functions in megakaryopoiesis and platelet formation
Gieger, Christian, Radhakrishnan, Aparna, Cvejic, Ana, Tang, Weihong, Porcu, Eleonora, Pistis, Giorgio, Serbanovic-Canic, Jovana, Elling, Ulrich, Goodall, Alison H., Labrune, Yann, Lopez, Lorna M., Magi, Reedik, Meacham, Stuart, Okada, Yukinori, Pirastu, Nicola, Sorice, Rossella, Teumer, Alexander, Voss, Katrin, Zhang, Weihua, Ramirez-Solis, Ramiro, Bis, Joshua C., Ellinghaus, David, Gogele, Martin, Hottenga, Jouke-Jan, Langenberg, Claudia, Kovacs, Peter, O'Reilly, Paul F., Shin, So-Youn, Esko, Tonu ... Soranzo, Nicole (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201-208. doi: 10.1038/nature10659
Frazer, Ian H. and Levin, Myron J. (2011). Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer. Current Opinion in Virology, 1 (4), 268-279. doi: 10.1016/j.coviro.2011.07.007
New approaches to immunotherapy for HPV associated cancer
Bergot, Anne-Sophie, Kassianos, Andrew, Frazer, Ian H. and Mittal, Deepak (2011). New approaches to immunotherapy for HPV associated cancer. Cancers, 3 (3), 3461-3495. doi: 10.3390/cancers3033461
LPAR1 and ITGA4 Regulate Peripheral Blood Monocyte Counts
Maugeri, Narelle, Powell, Joseph E., 't Hoen, Peter A. C., de Geus, Eco J. C., Willemsen, Gonneke, Kattenberg, Mathijs, Henders, Anjali K., Wallace, Leanne, Penninx, Brenda, Hottenga, Jouke-Jan, Medland, Sarah E., Saviouk, Viatcheslav, Martin, Nicholas G., Visscher, Peter M., van Ommen, Gert-Jan B., Frazer, Ian H., Boomsma, Dorret I., Montgomery, Grant W. and Ferreira, Manuel A. R (2011). LPAR1 and ITGA4 Regulate Peripheral Blood Monocyte Counts. Human Mutation, 32 (8), 873-876. doi: 10.1002/humu.21536
NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins
Mattarollo, Stephen R., Yong, Michelle, Gosmann, Christina, Choyce, Allison, Chan, Dora, Leggatt, Graham R. and Frazer, Ian H. (2011). NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins. Journal of Immunology, 187 (4), 1601-1608. doi: 10.4049/jimmunol.1100756
Chen, Xianfeng, Fernando, Germain J. P., Crichton, Michael L., Flaim, Christopher, Yukiko, Sally R., Fairmaid, Emily J., Corbett, Holly J., Primiero, Clare A., Ansaldo, Alexander B., Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2011). Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization. Journal of Controlled Release, 152 (3), 349-355. doi: 10.1016/j.jconrel.2011.02.026
Ruutu, Merja P., Chen, Xianfeng, Joshi, Ojas, Kendall, Mark A. and Frazer, Ian H. (2011). Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen. Experimental Dermatology, 20 (6), 534-536. doi: 10.1111/j.1600-0625.2010.01234.x
Zhou, Fang, Leggatt, Graham R. and Frazer, Ian H. (2011). Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis. The Federation of European Biochemical Societies (FEBS) Journal, 278 (6), 955-963. doi: 10.1111/j.1742-4658.2011.08011.x
Prevention and treatment of papillomavirus-related cancers through immunization
Frazer, Ian H., Leggatt, Graham R. and Mattarollo, Stephen R. (2011). Prevention and treatment of papillomavirus-related cancers through immunization. Annual Review of Immunology, 29, 111-138. doi: 10.1146/annurev-immunol-031210-101308
Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy
Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H. and Leggatt, Graham R. (2011). Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy. Immunological Reviews, 239 (1), 85-98. doi: 10.1111/j.1600-065X.2010.00966.x
Corbett, Holly J., Fernando, Germain J. P., Chen, Xianfeng, Frazer, Ian H. and Kendall, Mark A. F. (2010). Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model. PLoS One, 5 (10) e13460, e13460.1-e13460.9. doi: 10.1371/journal.pone.0013460
Development of therapeutic HPV vaccines
Trimble, C. L. and Frazer, Ian H. (2010). Development of therapeutic HPV vaccines. Lancet Oncology, 10 (10), 975-980. doi: 10.1016/S1470-2045(09)70227-X
McAdam, Margaret, Sakita, Jerol, Tarivonda, Len, Pang, James and Frazer, Ian H. (2010). Evaluation of a cervical cancer screening program based on HPV testing and LLETZ excision in a low resource setting. PLoS One, 5 (10) e13266, e13266.1-e13266.6. doi: 10.1371/journal.pone.0013266
IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes
Hadis, Usriansyah, Leggatt, Graham R., Thomas, Ranjeny, Frazer, Ian H. and Kovacs, Eva M. (2010). IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Experimental Dermatology, 19 (8), 723-729. doi: 10.1111/j.1600-0625.2010.01092.x
Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice
Prow, Tarl W., Chen, Xianfeng, Prow, Natalie A., Fernando, Germain J. P., Tan, Cindy S. E., Raphael, Anthony P., Chang, David, Ruutu, Merja P., Jenkins, Derek W. K., Pyke, Alyssa, Crichton, Michael L., Raphaelli, Kristin, Goh, Lucas Y. H., Frazer, Ian H., Roberts, Michael S., Gardner, Joy, Khromykh, Alexander A., Suhrbier, Andreas, Hall, Roy A. and Kendall, Mark A. F. (2010). Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice. Small, 6 (16), 1776-1784. doi: 10.1002/smll.201000331
De Kluyver, Rachel L., Moritz, Linnea, Harris, Craig A., Azukizawa, Hiroaki and Frazer, Ian H. (2010). Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-γ-dependent mechanism. Journal of Investigative Dermatology, 130 (7), 1841-1848. doi: 10.1038/jid.2010.49
Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes
Broom, Jennifer K., Lew, Andrew M., Azukizawa, Hiroaki, Kenna, Tony J., Leggatt, Graham R. and Frazer, Ian H. (2010). Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes. Journal of Investigative Dermatology, 130 (6), 1581-1589. doi: 10.1038/jid.2010.17
Measuring serum antibody to human papillomavirus following infection or vaccination
Frazer, Ian H. (2010). Measuring serum antibody to human papillomavirus following infection or vaccination. Gynecologic Oncology, 118 (1 Supplement 1), S8-S11. doi: 10.1016/j.ygyno.2010.04.003
Mattarollo, Stephen R., Yong, Michelle, Tan, Lieven, Frazer, Ian H. and Leggatt, Graham R. (2010). Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. Journal of Immunology, 184 (10), 5663-5669. doi: 10.4049/jimmunol.0903730
The two faces of human papillomavirus
Frazer, Ian H. (2010). The two faces of human papillomavirus. Gynecologic Oncology, 117 (2), S4-S4. doi: 10.1016/j.ygyno.2010.01.023
Ding, Jianmin, Doorbar, John, Li, Bo, Zhou, Fang, Gu, Wenyi, Zhao, Liang, Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2010). Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes. Virology, 399 (1), 46-58. doi: 10.1016/j.virol.2009.12.021
Mattarollo, Stephen R., Rahimpour, Azad, Choyce, Allison, Godfrey, Dale I., Leggatt, Graham R. and Frazer, Ian H. (2010). Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production. Journal of Immunology, 184 (3), 1242-1250. doi: 10.4049/jimmunol.0902191
Ferreira, Mar, Mangino, M, Brumme, CJ, Zhao, ZZ, Medland, SE, Wright, MJ, Nyholt, DR, Gordon, S, Campbell, M, McEvoy, BP, Henders, A, Evans, DM, Lanchbury, JS, Pereyra, F, Walker, BD, Haas, DW, Soranzo, N, Spector, TD, de Bakker, PIW, Frazer, IH, Montgomery, GW, Martin, NG and Int HIV Controllers Study (2010). Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. American Journal of Human Genetics, 86 (1), 88-92. doi: 10.1016/j.ajhg.2009.12.008
Cervical cancer vaccine development
Frazer, Ian H. (2010). Cervical cancer vaccine development. Sexual Health, 7 (3), 230-234. doi: 10.1071/SH09132
Fernando, Germain J. P., Chen, Xianfeng, Prow, Tarl W., Crichton, Michael L., Fairmaid, Emily J., Roberts, Michael S., Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2010). Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS One, 5 (4) e10266, e10266.1-e10266.11. doi: 10.1371/journal.pone.0010266
Shelley, Michael, Pakenham, Kenneth Ian and Frazer, Ian (2009). Cortisol changes interact with the effects of a cognitive behavioural psychological preparation for surgery on 12-month outcomes for surgical heart patients. Psychology & Health, 24 (10), 1139-1152. doi: 10.1080/08870440802126704
Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis
Zhou, F, Frazer, IH and Leggatt, GR (2009). Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis. EXPERIMENTAL DERMATOLOGY, 18 (12), 1053-1059. doi: 10.1111/j.1600-0625.2009.00907.x
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
Benyamin, B, Ferreira, MAR, Willemsen, G, Gordon, S, Middelberg, RPS, McEvoy, BP, Hottenga, JJ, Henders, AK, Campbell, MJ, Wallace, L, Frazer, IH, Heath, AC, de Geus, EJC, Nyholt, DR, Visscher, PM, Penninx, BW, Boomsma, DI, Martin, NG, Montgomery, GW and Whitfield, JB (2009). Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nature Genetics, 41 (11), 1173-1175. doi: 10.1038/ng.456
Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin
Chen, Xianfeng, Prow, Tarl W., Crichton, Michael L., Jenkins, Derek W.K., Roberts, Michael S., Frazer, Ian H., Fernando, Germain J.P. and Kendall, Mark A.F. (2009). Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin. Journal of Controlled Release, 139 (3), 212-220. doi: 10.1016/j.jconrel.2009.06.029
Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume
Ferreira, MAR, Hottenga, JJ, Warrington, NM, Medland, SE, Willemsen, G, Lawrence, RW, Gordon, S, de Geus, EJC, Henders, AK, Smit, JH, Campbell, MJ, Wallace, L, Evans, DM, Wright, MJ, Nyholt, DR, James, AL, Beilby, JP, Penninx, BW, Palmer, LJ, Frazer, IH, Montgomery, GW, Martin, NG and Boomsma, DI (2009). Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume. AMERICAN JOURNAL OF HUMAN GENETICS, 85 (5), 745-749. doi: 10.1016/j.ajhg.2009.10.005
Liu, Xiao Song, Leerberg, Joanne, MacDonald, Kelli, Leggatt, Graham and Frazer, Ian (2009). IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. The Jounral of Immunology, 183 (1), 51-58. doi: 10.4049/jimmunol.0802047
Interaction of human papillomaviruses with the host immune system: A well evolved relationship
Frazer, Ian (2009). Interaction of human papillomaviruses with the host immune system: A well evolved relationship. Virology, 384 (2), 410-414. doi: 10.1016/j.virol.2008.10.004
Narayan, S., Choyce, A., Linedale, R., Saunders, N. A., Dahler, A., Chan, E., Fernando, G. J., Frazer, I. H. and Leggatt, G. R. (2009). Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4(+)CD25(+) T cells. European Journal of Immunology, 39 (2), 481-490. doi: 10.1002/eji.200838527
Li, Bo, Wang, Xiao, Zhou, Fang, Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2008). Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker. Differentiation, 76 (10), 1068-1080. doi: 10.1111/j.1432-0436.2008.00300.x
Autoimmunity and persistent viral infection: Two sides of the same coin?
Frazer, Ian (2008). Autoimmunity and persistent viral infection: Two sides of the same coin?. Journal of Autoimmunity, 31 (3), 216-218. doi: 10.1016/j.jaut.2008.04.014
Garland, S., Park, S. N., Ngan, H. Y. S., Frazer, I., Tay, E. H., Chen, C. J., Bhatla, N., Pitts, M., Shin, H. R., Konno, R., Smith, J., Pagliusi, S. and Park, J. S. (2008). The need for public education on HPV and cervical cancer prevention in Asia: Opinions of experts at the AOGIN Conference. Vaccine, 26 (43), 5435-5440. doi: 10.1016/j.vaccine.2008.07.077
Therapeutic vaccination against cervical cancer – are we near?
Merja Ruutu, Frazer, Ian H. and Liu, Xiaosong (2008). Therapeutic vaccination against cervical cancer – are we near?. Cancer Forum, 32 (2), 98-105.
HPV vaccines and the prevention of cervical cancer
Frazer, Ian H. (2008). HPV vaccines and the prevention of cervical cancer. UPDATE ON CANCER THERAPEUTICS, 3 (1), 43-48. doi: 10.1016/j.uct.2008.02.002
Zhong, Jie, Usriansyah Usriansyah, Rachel De Kluyver, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2008). TLR7 stimulation augments T effector-mediated rejection, of skin expressing neo-self antigen in keratinocytes. European Journal of Immunology, 38 (1), 73-81. doi: 10.1002/eji.200737599
Correlating immunity with protection for HPV infection
Frazer, I. H. (2007). Correlating immunity with protection for HPV infection. International journal of infectious diseases, 11 (S2), S10-S16. doi: 10.1016/S1201-9712(07)60016-2
HPV immunisation: A significant advance in cancer control
Frazer, I. H. (2007). HPV immunisation: A significant advance in cancer control. Gynecologic Oncology, 107 (2 Supp. 1), S1-S1. doi: 10.1016/j.ygyno.2007.07.071
Gu, Wenyi, Ding, Jianmin M., Wang, Xiao, de Kluyver, Rachel L., Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2007). Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Research, 35 (14), 4820-4832. doi: 10.1093/nar/gkm496
Fang, N. X., Gu, W., Ding, J., Saunders, N. A., Frazer, I. H. and Zhao, K. N. (2007). Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes. Virology, 365 (1), 187-197. doi: 10.1016/j.virol.2007.03.038
Carroll, Lisa, Frazer, Ian H., Turner, Malcolm, Marwick, Thomas H. and Thomas, Ranjeny (2007). Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis. Arthritis Research and Therapy, 9 (2) R39, R39.1-R39.8. doi: 10.1186/ar2175
Frazer, I. H. (2007). Medical Oncology Group of Australia, Pierre Fabre Cancer Achievement Award: Papillomavirus specific immunity as a means to prevent deaths from cervical cancer. Cancer Forum, 31 (1), 26-28.
HPV vaccines: the beginning of the end for cervical cancer
Leggatt, G. R. and Frazer, I. H. (2007). HPV vaccines: the beginning of the end for cervical cancer. Current Opinion In Immunology, 19 (2), 232-238. doi: 10.1016/j.coi.2007.01.004
Genomewide scans of red cell indices suggest linkage on chromosome 6q23
Iliadou, A., Evans, D. M., Zhu, G., Duffy, D. L., Frazer, I. H., Montgomery, G. W. and Martin, N. G. (2007). Genomewide scans of red cell indices suggest linkage on chromosome 6q23. Journal of Medical Genetics, 44 (1), 24-30. doi: 10.1136/jmg.2006.043521
HPV vaccination: what do Queensland parents think?
Hausdorf. K., Newman, B., Whiteman, D., Aitken, J. and Frazer, I. (2007). HPV vaccination: what do Queensland parents think?. Australia nad New Zealand Journal of Public Health, 31 (3), 288-289. doi: 10.1111/j.1467-842X.2007.00066.x
Prevention of cancer through immunization: Prospects and challenges for the 21st century
Frazer, I.H., Lowry, D.R. and Schiller, J.T. (2007). Prevention of cancer through immunization: Prospects and challenges for the 21st century. European Journal of Immunology, 37 (S1), S148-S155. doi: 10.1002/eji.200737820
Frazer, I. H. (2007). The Greg Johnson memorial oration. Translational research in new areas: Lessons from papillomavirus immunotherapy. Journal of Gene Medicine, 9 (6), 526-526.
Vaccination to prevent cervical cancer: a dream turned reality, with a twist in the tail
Frazer, I. H. (2007). Vaccination to prevent cervical cancer: a dream turned reality, with a twist in the tail. The Journal of BIOLaw & Business, Special supplement: Australia, 44-47.
Frazer, Ian H. (2006). Chapter 8 HPV vaccines. International Journal of Gynecology and Obstetrics, 94 (Supp. 1), S81-S88. doi: 10.1016/S0020-7292(07)60014-9
Delivering papillomavirus vaccines when and where they are most needed
Frazer, I. H. (2006). Delivering papillomavirus vaccines when and where they are most needed. Human Vaccines, 2 (5), 227-229. doi: 10.4161/hv.2.5.3345
Liu, Xiao Song, Dyer, Joanne, Leggatt, Graham R., Fernando, Germain J. P., Zhong, Jie, Thomas, Ranjeny and Frazer, Ian H. (2006). Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host. Journal of Immunology, 177 (5), 2873-2879. doi: 10.4049/jimmunol.177.5.2873
Prophylactic HPV vaccines: Underlying mechanisms
Stanley, Margaret, Lowy, Douglas R. and Frazer, Ian (2006). Prophylactic HPV vaccines: Underlying mechanisms. Vaccine, 24 (Supplement 3: HPV Vaccines and Screening in the Prevention of Cervical Cancer), S106-S113. doi: 10.1016/j.vaccine.2006.05.110
Finding a vaccine for human papillomavirus
Frazer, Ian H. and Cox, John (2006). Finding a vaccine for human papillomavirus. The Lancet, 367 (9528), 2058-2059. doi: 10.1016/S0140-6736(06)68921-6
Advances in prevention of cervical cancer and other human papillomavirus-related diseases
Frazer, Ian H., Cox, J. Thomas, Mayeaux, Edward John, Franco, Eduardo L., Moscicki, Anna-Barbara, Palefsky, Joel M., Ferris, Daron G., Ferenczy, Alex S. and Villa, Luisa L. (2006). Advances in prevention of cervical cancer and other human papillomavirus-related diseases. Pediatric Infectious Disease Journal, 25 (Supp. 2), S65-S81. doi: 10.1097/01.inf.0000196485.86376.46
God's gift to women: The human papillomavirus vaccine
Frazer, I. (2006). God's gift to women: The human papillomavirus vaccine. Immunity, 25 (2), 179-184. doi: 10.1016/j.immuni.2006.08.002
Harnessing the immune system to prevent cervical cancer
Frazer, I. H. (2006). Harnessing the immune system to prevent cervical cancer. Cancer Forum, 30 (2), 115-117.
IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
Peng, J. C., Abu Bakar, S., Richardson, M. M., Jonsson, J. J., Frazer, I. H., Nielsen, L. K., Morahan, G. and Thomas, R. (2006). IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS. Immunology And Cell Biology, 84 (2), 227-232. doi: 10.1111/j.1440-1711.2006.01419.x
Progress in cancer control: the Alan Coates effect
Frazer, I. H. and Kefford, R. F. (2006). Progress in cancer control: the Alan Coates effect. Cancer Forum, 30 (2), 96-97.
Tabrizi, SN, Frazer, IH and Garland, SM (2006). Serologic response to human papillomavirus 16 among Australian women with high-grade cervical intraepithelial neoplasia. International Journal of Gynecological Cancer, 16 (3), 1032-1035. doi: 10.1111/j.1525-1438.2006.00587.x
A model of peripheral CD8(+) T cell tolerance against skin antigen
Narayan, S., Fernando, G., Frazer, I. H. and Leggatt, G. (2005). A model of peripheral CD8(+) T cell tolerance against skin antigen. Tissue Antigens, 66 (5), 501-501. doi: 10.1111/j.1399-0039.2005.00523.x
Apoptosis mediated by CD8+T cells targeted to endogenous antigens in transgenic keratinocytes
Zhou, F., Leggatt, G., Zhong, J., Zhao, K., De Kluyver, R. and Frazer, I. H. (2005). Apoptosis mediated by CD8+T cells targeted to endogenous antigens in transgenic keratinocytes. Tissue Antigens, 66 (5), 600-600. doi: 10.1111/j.1399-0039.2005.00523.x
Interferon-gamma is required for killing keratinocytes in vitro and in vivo
De Kluyver, R. L., Morritz, L., Leggatt, G. R., Harris, C., Lambert, P. F. and Frazer, I. H. (2005). Interferon-gamma is required for killing keratinocytes in vitro and in vivo. Tissue Antigens, 66 (5), 394-394.
Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen
Zhong, J., De Kluyver, R., Leggatt, G. R., Fernando, G. J. and Frazer, I. H. (2005). Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen. Tissue Antigens, 66 (5), 600-600.
The role of CD4 T help in multiple vaccinations when using minimal CD8 T cell epitope peptides
Khammanivong, V., Peters, T., Andrews, M., Leggatt, G. R., Frazer, I. H. and Fernando, G. J. (2005). The role of CD4 T help in multiple vaccinations when using minimal CD8 T cell epitope peptides. Tissue Antigens, 66 (5), 415-415.
Leggatt, G. R., Saunders, N., Dahler, A., Fernando, G. J., Matsumoto, K., Narayan, S., Linedale, R., Choyce, A. and Frazer, I. H. (2005). Transgenic expression of a viral oncoprotein exclusively in K14(+) epithelial cells results in peripheral but not central CD8 T cell tolerance. Tissue Antigens, 66 (5), 475-476.
Zhao, Kong-Nan, Gu, WenYi, Fang, Ning Xia, Saunders, Nicholas A. and Frazer, Ian H. (2005). Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo. Molecular And Cellular Biology, 25 (19), 8643-8655. doi: 10.1128/MCB.25.19.8643-8655.2005
HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood
Pinto, Ligia A., Castle, Philip E., Roden, Richard B., Harro, Clayton D., Lowy, Douglas R., Schiller, John T., Wallace, Dora, Williams, Marcus, Kopp, William, Frazer, Ian H., Berzofsky, Jay A. and Hildesheim, Allan (2005). HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood. Vaccine, 23 (27), 3555-3564. doi: 10.1016/j.vaccine.2005.01.146
Yan, Mengyong, Peng, Judy, Jabbar, Ibtissam A., Liu, Xiaosong, Filguueira, Luis, Frazer, Ian H. and Thomas, Ranjeny (2005). Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-B-mediated signalling, moderated by TGF-beta. Immunology and Cell Biology, 83 (1), 83-91. doi: 10.1111/j.1440-1711.2004.01291.x
deKluyver, R. L., Moritz, L. and Frazer, I. H. (2005). Interferon-gamma, but not perforin or FasL, is required for killing keratinocytes in vitro and in vivo. Faseb Journal, 19 (5), A1438-A1438.
Overcoming original antigenic sin to generate effective immune responses in antigen primed host
Liu, X., Leggatt, G., Fernando, G. J. and Frazer, I. H. (2005). Overcoming original antigenic sin to generate effective immune responses in antigen primed host. Tissue Antigens, 66 (5), 481-481.
Functional memory CD8+ T cells can be generated in vivo without evident T help
Andrews, Melanie R., Peters, Tania, Khammanivong, Vithagna, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2004). Functional memory CD8+ T cells can be generated in vivo without evident T help. Vaccine, 23 (6), 739-742. doi: 10.1016/j.vaccine.2004.07.027
Zhong, J., Matsumoto, K., De Kluyver, R., Fernando, G. J. P., Leggatt, G. R. and Frazer, I. H. (2004). Human growth hormone (hGH) presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection. Journal of Investigative Dermatology, 123 (6), A113-A113.
Frazer, Ian H., Quinn, Michael, Nicklin, Jim L., Tan, Jeffrey, Perrin, Lew C., Ng, Peng, O'Connor, Vivienne M., White, Olivia, Wendt, Ngaire, Martin, Juliet, Crowley, Jayne M., Edwards, Stirling J., McKenzie, Andrew W., Mitchell, Susan V., Maher, Darryl W., Pearse, Martin J. and Basser, Russell L. (2004). Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX (TM) adjuvant in women with cervical intraepithelial neoplasia. Vaccine, 23 (2), 172-181. doi: 10.1016/j.vaccine.2004.05.013
Leggatt, Graham R., Narayan, Sharmal, Fernando, Germain J. P. and Frazer, Ian H. (2004). Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes. Journal of Leukocyte Biology, 76 (4), 787-795. doi: 10.1189/jlb.0104026
Major quantitative trait locus for eosinophil count is located on chromosome 2q
Evans, DM, Zhu, G, Duffy, DL, Montgomery, GW, Frazer, IH and Martin, NG (2004). Major quantitative trait locus for eosinophil count is located on chromosome 2q. Journal of Allergy And Clinical Immunology, 114 (4), 826-830. doi: 10.1016/j.jaci.2004.05.060
Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation
Stewart, Trina J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2004). Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation. Immunology and Cell Biology, 82 (5), 455-461. doi: 10.1111/j.0818-9641.2004.01273.x
ISCOMATRIX (TM) adjuvant: An adjuvant suitable for use in anticancer vaccines
Stewart, Trina J., Drane, Debbie, Malliaros, Jim, Elmer, Heidi, Malcolm, Karen M., Cox, John C., Edwards, Stirling J., Frazer, Ian H. and Fernando, Germain J. P. (2004). ISCOMATRIX (TM) adjuvant: An adjuvant suitable for use in anticancer vaccines. Vaccine, 22 (27-28), 3738-3743. doi: 10.1016/j.vaccine.2004.03.026
Yan, Mengyong, Peng, Judy, Abdul Jabbar, Ibtissam A., Liu, Xiaosong, Filgueira, Luis, Frazer, Ian H. and Thomas, Ranjeny (2004). Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells. Virology, 324 (2), 297-310. doi: 10.1016/j.virol.2004.03.045
Monsonego, J., Bosch, F. X., Coursaget, P., Cox, J. T., Franco, E., Frazer, I., Sankaranarayanan, R., Schiller, J., Singer, A., Wright Jr., Thomas C., Kinney, W., Meijer, Chris J.L.M., Linder, J. and McGoogan, Euphemia (2004). Erratum: Cervical cancer control, priorities and new directions (International Journal of Cancer (2003) 108 (329-333)). International Journal of Cancer, 108 (6)
Juffs, Helen, Fowler, Nina, Saal, Russell, Grimmett, Karen, Beasley, Shannon, O'Sullivan, Brendan, Frazer, Ian H., Gill, Devinder and Thomas, Ranjeny (2004). B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma. Pathology, 36 (1), 69-76. doi: 10.1080/00313020310001644499
A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11
Evans, D. M., Zhu, G., Duffy, D. L., Frazer, I. H., Montgomery, G. W. and Martin, N. G. (2004). A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11. Genes and Immunity, 5 (7), 548-552. doi: 10.1038/sj.gene.6364126
Cervical Cancer Control, Priorities and New Directions
Monsonego, J, Bosch, FX, Coursaget, P, Cox, JT, Franco, E, Frazer, I, Sankaranarayanan, R, Schiller, J, Singer, A, Wright, T, Kinney, W, Meijer, C and Linder, J (2004). Cervical Cancer Control, Priorities and New Directions. International Journal of Cancer, 108 (3), 329-333. doi: 10.1002/ijc.11530
Liu, X. S., Xu, Y., Zhao, W. M., Fernando, G. J. P., Leggatt, G. R. and Frazer, I. H. (2004). Erratum: IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host (Journal of Immunology (2003) 171 (4765-4772)). Journal of Immunology, 172 (2), 1311-1311. doi: 10.4049/jimmunol.172.2.1311-a
Zhong, Jie, Matsumoto, Koji, De Kluyver, Rachel, Fernando, Germain J. P., Leggatt, Graham R. and Frazer, Ian H. (2004). Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection. Immunology and Cell Biology, 82 (6), 577-586. doi: 10.1111/j.1440-1711.2004.01292.x
Matsumoto, K., Leggatt, G. R., Zhong, J., Liu, X. S., De Kluyver, R. L., Peters, T., Fernando, G. J. P., Liem, A., Lambert, P. F. and Frazer, I. H. (2004). Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors. Journal of the National Cancer Institute, 96 (21), 1611-1619. doi: 10.1093/jnci/dhj301
Is vaccine therapy the future in cancer prevention?
Frazer, I. H. (2004). Is vaccine therapy the future in cancer prevention?. Expert Opinion on Pharmacotherapy, 5 (12), 2427-2434. doi: 10.1517/14656566.5.12.2427
Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q
Evans, D. M., Zhu, G., Duffy, D. L., Montgomery, G. W., Frazer, IH and Martin, NG (2004). Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q. European Journal of Human Genetics, 12 (10), 835-842. doi: 10.1038/sj.ejhg.5201248
Mutations in TAP genes are common in cervical cancinomas
Fowler, NL and Frazer, IH (2004). Mutations in TAP genes are common in cervical cancinomas. Gynecologic Oncology, 92 (3), 914-921. doi: 10.1016/j.ygyno.2003.11.037
Prevention of Cervical Cancer Through Papillomavirus Vaccination
Frazer, Ian H. (2004). Prevention of Cervical Cancer Through Papillomavirus Vaccination. Nature Reviews Immunology, 4 (1), 46-55. doi: 10.1038/nri1260
Gu, Wenyi, Li, Mengrong, Zhao, Wei Ming, Fang, Ning Xia, Bu, Shurui, Frazer, Ian H. and Zhao, Kong-Nan (2004). tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes. Nucleic Acids Research, 32 (15), 4448-4461. doi: 10.1093/nar/gkh748
Effects of additional sequences directly downstream from the AUG on the expression of GFP gene
Zhao, Kong-Nan, Tomlinson, Liz, Liu, Wen Jun, Gu, Wenyi and Frazer, Ian H. (2003). Effects of additional sequences directly downstream from the AUG on the expression of GFP gene. BBA - Biochimeca et Biophysica Acta: international journal of biochemistry and biophysics, 1630 (2-3), 84-95. doi: 10.1016/j.bbaexp.2003.09.010
Liu, Xiao Song, Xu, Yan, Hardy, Lani, Khammanivong, Vithagna, Zhao, Weiming M., Fernando, Germain J. P., Leggatt, Graham R. and Frazer, Ian H. (2003). IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host. Journal of Immunology, 171 (9), 4765-4772. doi: 10.4049/jimmunol.171.9.4765
HPV 6b L1 virus-like particles elicit humoral immunity in mice
Liu, Yuehua, Liu, Wenjun, Liu, Xiaosong and Frazer, Ian H. (2003). HPV 6b L1 virus-like particles elicit humoral immunity in mice. Chinese Medical Sciences Journal, 18 (3), 185-188.
Chapter 16: Prophylactic Human Papillomavirus Vaccines
Lowy, Douglas R. and Frazer, Ian H. (2003). Chapter 16: Prophylactic Human Papillomavirus Vaccines. Journal of the National Cancer Institute Monographs, 31 (31), 111-116.
Malcolm, K. M., Gill, J., Leggatt, G. R., Boyd, R., Lambert, P. and Frazer, I. H. (2003). Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age. Clinical and Developmental Immunology, 10 (2-4), 91-103. doi: 10.1080/10446670310001626562
Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells
Stewart, Trina J., Smyth, Mark J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2003). Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells. Cancer Research, 63 (12), 3058-3060.
Codon usage bias and A+T content variation in human papillomavirus genomes
Zhao, K. N., Liu, W. J. and Frazer, I. H. (2003). Codon usage bias and A+T content variation in human papillomavirus genomes. Virus Research, 98 (2), 95-104. doi: 10.1016/j.viruses.2003.08.019
Khammanivong, Vithagna, Liu, Xiao Song, Liu, Wen Jun, Rodda, Stuart J., Leggatt, Graham R., Tindle, Robert W., Frazer, Ian H. and Fernando, Germain J. P. (2003). Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16. Immunology and Cell Biology, 81 (1), 1-7. doi: 10.1046/j.1440-1711.2003.01130.x
Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1
Zhao, Kong-Nan and Frazer, Ian H. (2002). Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1. Journal of Virology, 76 (23), 12265-12273. doi: 10.1128/JVI.76.23.12265-12273.2002
Gao, Feng Guang, Khammanivong, Vithagna, Liu, Wen Jun, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2002). Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell. Cancer Research, 62 (22), 6438-6441.
Vaccines for papillomavirus infection
Frazer, Ian H. (2002). Vaccines for papillomavirus infection. Virus Research, 89 (2), 271-274. doi: 10.1016/S0168-1702(02)00195-8
Leggatt, Graham R., Dunn, Linda A., De Kluyver, Rachel L., Stewart, Trina and Frazer, Ian H. (2002). Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide. Immunology and Cell Biology, 80 (5), 415-424. doi: 10.1046/j.1440-1711.2002.01105.x
Dale, C. Jane, Liu, Xiao Song Song, De Rose, Robert, Purcell, Damian F. J., Anderson, Jenny, Xu, Yan, Leggatt, Graham R., Frazer, Ian H. and Kent, Stephen J. (2002). Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques. Virology, 301 (1), 176-187. doi: 10.1006/viro.2002.1589
Liu, Wen Jun, Gao, Fengguang, Zhao, Kong Nan, Zhao, Weiming, Fernando, Germain J. G., Thomas, Ranjeny and Frazer, Ian H. (2002). Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity. Virology, 301 (1), 43-52. doi: 10.1006/viro.2002.1584
Immunogenicity study of HPV 6b virus-like particles
Liu , Y., Liu. X. and Frazer, I. H. (2002). Immunogenicity study of HPV 6b virus-like particles. Chung-Hua i Hsueh Tsa Chih [Chinese Medical Journal], 82 (9), 587-589.
Hospital and outpatient health services utilization among HIV-infected patients in care in 1999
Crane, L, Crowe, R, Fine, S, Gold, M, Gorosh, K, Gourevitch, M, Hellinger, J, Jovanovich, J, Kalkut, G, Keiser, P, Matthews, C, Nadler, J, Nemechek, P, Post, J, Goldberg, B, Rutstein, R, Sharp, V, Hollinger, F, Fleishman, J, Frazer, I, Conviser, R, Dilonardo, J, Gaist, P, Moore, R, Keruly, J, Gebo, K, Reilly, E and Zhao, M (2002). Hospital and outpatient health services utilization among HIV-infected patients in care in 1999. Journal of Acquired Immune Deficiency Syndromes, 30 (1), 21-26.
Zhao, Kong-Nan and Frazer, Ian H. (2002). Replication of bovine papillomavirus type 1 (BPV-1) DNA in Saccharomyces cerevisiae following infection with BPV-1 virions. Journal of Virology, 76 (7), 3359-3364. doi: 10.1128/JVI.76.7.3359-3364.2002
Thompson, Angus G., Pettit, Allison R., Padmanabha, Jagdish, Mansfield, Helen, Frazer, Ian H ., Strutton, Geoff M. and Thomas, Ranjeny (2002). Nuclear RelB(+) cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditions. Immunology and Cell Biology, 80 (2), 164-169. doi: 10.1046/j.1440-1711.2002.01070.x
Route of administration of chimeric BPV1VLP determines the character of the induced immune responses
Liu, Xiao Song, Liu, Wen Jun, Zhao, Kong Nan, Liu, Yue Hua, Leggatt, Graham and Frazer, Ian H. (2002). Route of administration of chimeric BPV1VLP determines the character of the induced immune responses. Immunology and Cell Biology, 80 (1), 21-29. doi: 10.1046/j.1440-1711.2002.01051.x
Fernando, G. J. P., Khammanivong, V., Leggatt, G. R., Liu, W. J. and Frazer, I. H. (2002). The number of long-lasting functional memory CD8(+) T cells generated depends on the nature of the initial nonspecific stimulation. European Journal of Immunology, 32 (6), 1541-1549. doi: 10.1002/1521-4141(200206)32:6<1541::AID-IMMU1541>3.0.CO;2-S
Vaccines to prevent and treat cervical cancer
Frazer, I. (2002). Vaccines to prevent and treat cervical cancer. Cancer Forum, 26 (2), 113-114.
Liu, Wen jun, Zhao, Kong-Nan, Gao, Feng Guang, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2001). Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy. Vaccine, 20 (5-6), 862-869. doi: 10.1016/S0264-410X(01)00406-6
Frazer, Ian H., De Kluyver, Rachel L., Leggatt, Graham R., Guo, Hua, Dunn, Linda A., White, Olivia J., Harris, Craig, Liem, Amy and Lambert, Paul F. (2001). Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure. The Journal of Immunology, 167 (11), 6180-6187.
Frazer, Ian H., De Kluyver, Rachel, Leggatt, Graham R., Guo, Hua Yang, Dunn, Linda, White, Olivia, Harris, Craig, Liem, Amy and Lambert, Paul (2001). Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure. Journal of Immunology, 167 (11), 6180-6187. doi: 10.4049/jimmunol.167.11.6180
Tindle, Robert W., Herd, Karen A., Doan, Tracy, Bryson, Greg, Leggatt, Graham R., Lambert, Paul, Ian H. Frazer, and Street, Michael D. (2001). Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter. Journal of Virology, 75 (13), 5985-5997. doi: 10.1128/JVI.75.13.5985-5997.2001
Association of bovine papillomavirus type 1 with microtubules
Liu, Wen-Jun, Qi, Ying-Mei, Zhao, Kong-Nan, Liu, Yue-Hua, Liu, Xiao-Song and Frazer, Ian H. (2001). Association of bovine papillomavirus type 1 with microtubules. Virology, 282 (2), 237-244. doi: 10.1006/viro.2000.0728
Pettit, AR, Weedon, H, Ahern, M, Zehntner, S, Frazer, IH, Slavotinek, J, Au, V, Smith, MD and Thomas, R (2001). Association of clinical, radiological and synovial immunopathological responses to anti-rheumatic treatment in rheumatoid arthritis. Rheumatology, 40 (11), 1243-1255. doi: 10.1093/rheumatology/40.11.1243
Cervical carcinoma and human papillomavirus: on the road to preventing a major human cancer
Bosch, X. F., Munoz, N., de Sanjose, S., Franco, E. L. F., Lowy, D. R., Schiffman, M., Franceschi, S., Kruger Kjaer, S., Meijer, C. J. M. L., Frazer, I. H. and Cuzick, J. (2001). Cervical carcinoma and human papillomavirus: on the road to preventing a major human cancer. Journal of the National Cancer Institute, 93 (17), 1349-1350. doi: 10.1093/jnci/93.17.1349
Developmental genetics of red cell indices during puberty: A longitudinal twin study
Evans, D. M., Frazer, I. H., Boomsma, D. I. and Martin, N. G. (2001). Developmental genetics of red cell indices during puberty: A longitudinal twin study. International Journal of Human Genetics, 1 (1), 41-53. doi: 10.1080/09723757.2001.11885735
Efficiency of delivery of DNA to cells by bovine papillomavirus type-1 L1/L2 pseudovirions
Liu, Y., Frazer, I. H., Liu, W. J., Liu, X. S., McMillan, N. and Zhao, K. N. (2001). Efficiency of delivery of DNA to cells by bovine papillomavirus type-1 L1/L2 pseudovirions. Applied Microbiology And Biotechnology, 56 (1-2), 150-156. doi: 10.1007/s002530100655
Azoury-Ziadeh, R, Herd, K, Fernando, GJP, Lambert, P, Frazer, IH and Tindle, RW (2001). Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 protein. Virus Research, 73 (2), 189-199. doi: 10.1016/S0168-1702(00)00241-0
Bosch, F. X., Rohan, T., Schneider, A., Frazer, I., Pfister, H., Castellsague, X., de Sanjose, S., Moreno, V., Puig-Tintore, L. M., Smith, P. G., Munoz, N. and zur Hausen, H. (2001). Papillomavirus research update: highlights of the Barcelona HPV 2000 international papillomavirus conference. Journal of Clinical Pathology, 54 (3), 163-175. doi: 10.1136/jcp.54.3.163
Fang, N., Frazer, I. H. and Fernando, G. J. (2000). Differences in the post-translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus system. Biotechnology And Applied Biochemistry, 32 (1), 27-33. doi: 10.1042/BA20000001
Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes
Liu, WJ, Liu, XS, Zhao, KN, Leggatt, GR and Frazer, IH (2000). Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes. Virology, 273 (2), 374-382. doi: 10.1006/viro.2000.0435
BPV1 E2 protein enhances packaging of full-length plasmid DNA in BPV1 pseudovirions
Zhao, Kong-Nan, Hengst, Kylie, Liu, Wen-Jun, Liu, Yue Hua, Liu, Xiao Song, Mcmillan, Nigel A. J. and Frazer, Ian H. (2000). BPV1 E2 protein enhances packaging of full-length plasmid DNA in BPV1 pseudovirions. Virology, 272 (2), 382-393. doi: 10.1006/viro.2000.0348
Dicker, Anthony J., Popa, Claudia, Dahler, Alison L., Serewko, Magdelena M., Hilditch-Maguire, Paige A., Frazer, Ian H. and Saunders, Nicholas A. (2000). E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes. Oncogene, 19 (25), 2887-2894. doi: 10.1038/sj.onc.1203610
Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins
Abdul Jabbar, I., Fernando, G. J., Saunders, N. A., Aldovini, A., Young, R., Malcolm, K. M. and Frazer, I. H. (2000). Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. Vaccine, 18 (22), 2444-2453. doi: 10.1016/S0264-410X(99)00550-2
Malcolm, Karen M., Meschede, Wolfgang, Pawlita, Michael, Koutsky, Laura A. and Frazer, Ian H. (2000). Multiple conformational epitopes are recognized by natural and induced immunity to the E7 protein of human papilloma virus type 16 in man. Intervirology, 43 (3), 165-173. doi: 10.1159/000025042
HPV6b virus like particles are potent immunogens without adjuvant in man
Zhang, Li Fang, Zhou, Jian, Chen, Shao, Cai, Lian Lian, Bao, Qi Yu, Zheng, Fei Yun, Lu, Jie Qiang, Padmanabha, Jagadish, Hengst, Kylie, Malcolm, Karen and Frazer, Ian H. (2000). HPV6b virus like particles are potent immunogens without adjuvant in man. Vaccine, 18 (11-12), 1051-1058. doi: 10.1016/S0264-410X(99)00351-5
Predictors of genital warts among women attending two family planning clinics
Frazer, I. H., Howard, J., Cox, C. and McFadyn, S. (2000). Predictors of genital warts among women attending two family planning clinics. Venereology, 13 (4), 157-162.
Construction and production of fluorescent papillomavirus-like particles
Peng, S., Zhou, J. and Frazer, I. H. (1999). Construction and production of fluorescent papillomavirus-like particles. Journal of Tongji Medical University = Tung chi i ko ta hsueh hsueh pao, 19 (3), 170-174, 180.
Peng, Shiwen, Qi, Yingmei, Christensen, Neil, Hengst, Kylie, Kennedy, Lynn, Frazer, Ian H. and Tindle, Robert W. (1999). Capture ELISA and in vitro cell binding assay for the detection of antibodies to human papillomavirus type 6b virus-like particles in patients with anogenital warts. Pathology, 31 (4), 418-422. doi: 10.1080/003130299104846
Expression of the alpha 6 integrin confers papillomavirus binding upon receptor-negative B-cells
McMillan, Nigel A. J., Payne, Elizabeth, Frazer, Ian H. and Evander, Magnus (1999). Expression of the alpha 6 integrin confers papillomavirus binding upon receptor-negative B-cells. Virology, 261 (2), 271-279. doi: 10.1006/viro.1999.9825
Genetic and environmental causes of variation in basal levels of blood cells
Evans, David M., Frazer, Ian H. and Martin, Nicholas G. (1999). Genetic and environmental causes of variation in basal levels of blood cells. Twin Research, 2 (4), 250-257. doi: 10.1375/twin.2.4.250
Zhao, Kong-Nan, Frazer, Ian H., Liu, Wen Jun, Williams, Mark and Zhou, Jian (1999). Nucleotides 1506-1625 of Bovine Papillomavirus Type 1 Genome can enhance DNA packaging by L1/L2 capsids. Virology, 259 (1), 211-218. doi: 10.1006/viro.1999.9714
Zhou, Jian, Liu, Wen Jun, Peng, Shi Wen, Sun, Xiao Yi and Frazer, Ian H. (1999). Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability. Journal of Virology, 73 (6), 4972-4982. doi: 10.1128/JVI.73.6.4972-4982.1999
Post translational modifications of recombinant human Papillomavirus type 6b major capsid protein
Fang, Ning-Xia, Frazer, Ian H., Zhou, Jian and Fernando, Germain J. P. (1999). Post translational modifications of recombinant human Papillomavirus type 6b major capsid protein. Virus Research, 60 (2), 113-121. doi: 10.1016/S0168-1702(98)00117-8
Potential strategies utilised by papillomavirus to evade host immunity
Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian A., Leggatt, Graham R., Dunn, Linda, Mcmillan, Nigel A. J., Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula and Sharkey, Michael (1999). Potential strategies utilised by papillomavirus to evade host immunity. Immunological Reviews, 168 (1), 131-142. doi: 10.1111/j.1600-065X.1999.tb01288.x
Fernando, G. J. P., Murray, B., Zhou, J. and Frazer, I. H. (1999). Expression, purification and immunological characterization of the transforming protein E7, from cervical cancer-associated human papillomavirus type 16. Clinical & Experimental Immunology, 115 (3), 397-403. doi: 10.1046/j.1365-2249.1999.00813.x
Hilditch-Maguire, Paige A., Lieppe, Donna M., West, Donna M., Lambert, Paul F. and Frazer, Ian H. (1999). T cell-mediated and non-specific inflammatory mechanisms contribute to the skin pathology of HPV 16 E6E7 transgenic mice. Intervirology, 42 (1), 43-50. doi: 10.1159/000024959
Azoury-Ziadeh, Rania, Herd, Karen, Fernando, Germain J. P., Frazer, Ian H. and Tindle, Robert W. (1999). T-Helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16. Viral Immunology, 12 (4), 297-312. doi: 10.1089/vim.1999.12.297
Liu, Xiao Song, Abdul-Jabbar, Ibtissam, Qi, Ying Mei, Frazer, Ian H. and Zhou, Jian (1998). Mucosal immunisation with papillomavirus virus-like particles elicits systemic and mucosal immunity in mice. Virology, 252 (1), 39-45. doi: 10.1006/viro.1998.9442
Simplifying the molecular mechanisms of human papillomavirus
Saunders, Nicholas A. and Frazer, Ian H. (1998). Simplifying the molecular mechanisms of human papillomavirus. Dermatologic Clinics, 16 (4), 823-827. doi: 10.1016/S0733-8635(05)70054-1
Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes
Frazer, Ian H., Fernando, Germain J. P., Fowler, Nina, Leggatt, Graham R., Lambert, Paul F., Liem, Amy, Malcolm, Karen and Tindle, Robert W. (1998). Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. European Journal of Immunology, 28 (9), 2791-2800. doi: 10.1002/(SICI)1521-4141(199809)28:09<2791::AID-IMMU2791>3.0.CO;2-B
Th2-type CD4(+) cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model
Fernando, Germain J. P., Stewart, Trina J., Tindle, Robert W. and Frazer, Ian H. (1998). Th2-type CD4(+) cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model. Journal of Immunology, 161 (5), 2421-2427.
The role of the immune system in human papillomavirus infection
Frazer, I. (1998). The role of the immune system in human papillomavirus infection. Journal of Obstetrics and Gynaecology, 18 (5 Suppl 2), S72-S75. doi: 10.1080/01443619866598
Fernando, G. J. P., Stewart, T. J., Tindle, R. W. and Frazer, I. H. (1998). Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term. Scandinavian Journal of Immunology, 47 (5), 459-465. doi: 10.1046/j.1365-3083.1998.00327.x
DNA packaging by L1 and L2 capsid proteins of bovine papillomavirus type 1
Zhao, Kong-Nan, Sun, Xiao-Yi, Frazer, Ian H. and Zhou, Jian (1998). DNA packaging by L1 and L2 capsid proteins of bovine papillomavirus type 1. Virology, 243 (2), 482-491. doi: 10.1006/viro.1998.9091
Kulski, Jerzy K., Sadleir, John W., Kelsall, Stephen R., Cicchini, Maria S., Shellam, Geoffrey, Peng, Shi Wen, Qi, Ying Mei, Galloway, Denise A., Zhou, Jian and Frazer, Ian H. (1998). Type specific and genotype cross reactive B epitopes of the L1 protein of HPV16 defined by a panel of monoclonal antibodies. Virology, 243 (2), 275-282. doi: 10.1006/viro.1997.9011
Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathway
Peng, Shiwen W., Frazer, Ian H., Fernando, Germain J. P. and Zhou, Jian (1998). Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathway. Virology, 240 (1), 147-157. doi: 10.1006/viro.1997.8912
Histologic and immunohistochemical responses after aortic valve allografts in the rat
Green, Marjorie K., Walsh, Michael D., Dare, Anthony, Hogan, Patrick G., Zhao, Xiao-Ming, Frazer, Ian H., Bansal, Amolak S. and OBrien, Mark F. (1998). Histologic and immunohistochemical responses after aortic valve allografts in the rat. Annals of Thoracic Surgery, 66 (6), S216-S220. doi: 10.1016/S0003-4975(98)01123-0
Dunn, Linda A., Evander, Magnus, Tindle, Robert W., Bulloch, Anne Louise, de Kluyver, Rachel L., Fernando, Germain J. P., Lambert, Paul F. and Frazer, Ian H. (1997). Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animal. Virology, 235 (1), 94-103. doi: 10.1006/viro.1997.8650
Herd, K., Fernando, G. J. P., Dunn, L. A., Frazer, I. H., Lambert, P. and Tindle, R. W. (1997). E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology, 231 (1), 155-165. doi: 10.1006/viro.1997.8491
Identification of the alpha(6) integrin as a candidate receptor for papillomaviruses
Evander, Magnus, Frazer, Ian H., Payne, Elizabeth, Qi, Ying Mei, Hengst, Kylie and McMillan, Nigel A.J. (1997). Identification of the alpha(6) integrin as a candidate receptor for papillomaviruses. Journal of Virology, 71 (3), 2449-2456. doi: 10.1128/jvi.71.3.2449-2456.1997
Strategies for immunoprophylaxis and immunotherapy of papillomaviruses
Frazer, I. (1997). Strategies for immunoprophylaxis and immunotherapy of papillomaviruses. Clinics In Dermatology, 15 (2), 285-297. doi: 10.1016/S0738-081X(96)00151-4
Human aortic valve allografts elicit a donor-specific immune response
Hogan, P, Duplock, L, Green, M, Smith, S, Gall, KL, Frazer, IH and OBrien, MF (1996). Human aortic valve allografts elicit a donor-specific immune response. Journal of Thoracic and Cardiovascular Surgery, 112 (5), 1260-1266. doi: 10.1016/S0022-5223(96)70139-3
Immunology of papillomavirus infection
Frazer, IH (1996). Immunology of papillomavirus infection. Current Opinion in Immunology, 8 (4), 484-491. doi: 10.1016/S0952-7915(96)80035-5
Armstrong, DKB, Maw, RD, Dinsmore, WW, Blaakaer, J, Correa, MAG, Falk, L, Ferenczy, AS, Fortier, M, Frazer, I, Law, C, Moller, BM and Oyakawa, N (1996). Combined therapy trial with interferon alpha-2a and ablative therapy in the treatment of anogential warts. Genitourinary Medicine, 72 (2), 103-107. doi: 10.1136/sti.72.2.103
Familial primary antiphospholipid antibody syndrome
Bansal, AS, Hogan, PG, Gibbs, H and Frazer, IH (1996). Familial primary antiphospholipid antibody syndrome. Arthritis and Rheumatism, 39 (4), 705-706. doi: 10.1002/art.1780390427
Londono, L. Patricia, Chatfield, Steven, Tindle, Robert W., Herd, Karen, Gao, Xiao-Ming, Frazer, Ian and Dougan, Gordon (1996). Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen. Vaccine, 14 (6), 545-552. doi: 10.1016/0264-410X(95)00216-N
Qi, YM, Peng, SW, Hengst, K, Evander, M, Park, DS, Zhou, J and Frazer, IH (1996). Epithelial cells display separate receptors for papillomavirus VLPs and for soluble L1 capsid protein. Virology, 216 (1), 35-45. doi: 10.1006/viro.1996.0032
Boyle, M.J., Goldstein, D.A., Frazer, I.H. and Sculley, T.B. (1996). How HIV promotes malignancies. Medical Journal of Australia, 164 (4), 230-232.
The role of vaccines in the control of STDs: HPV vaccines
Frazer, I. H. (1996). The role of vaccines in the control of STDs: HPV vaccines. Genitourinary Medicine, 72 (6), 398-403. doi: 10.1136/sti.72.6.398
Sun, XY, Frazer, I, Muller, M, Gissmann, L and Zhou, J (1995). Sequences Required for the Nuclear Targeting and Accumulation of Human Papillomavirus Type 6B L2 Protein. Virology, 213 (2) 70005, 321-327. doi: 10.1006/viro.1995.0005
Tindle, Robert W. and Frazer, Ian H. (1995). Section review: Biologicals & immunologicals: Human papillomavirus infection, genital warts and cervical cancer: Prospects for prophylactic and therapeutic vaccines. Expert Opinion on Investigational Drugs, 4 (9), 783-797. doi: 10.1517/13543784.4.9.783
Frazer, I. H., Leippe, D. M., Dunn, L. A., Liem, A., Tindle, R. W., Fernando, G. J. P., Phelps, W. C. and Lambert, P. F. (1995). Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease. Cancer Research, 55 (12), 2635-2639.
Fong, K.M., Schonrock, J., Frazer, I.H., Zimmerman, P.V. and Smith, P.J. (1995). Human papillomavirus not found in squamous and large-cell lung carcinomas by polymerase chain-reaction. Cancer, 75 (9), 2400-2401. doi: 10.1002/1097-0142(19950501)75:9<2400::AID-CNCR2820750933>3.0.CO;2-6
Fernando, G.J.P., Tindle, R.W and Frazer, I.H. (1995). T-helper epitopes of the E7 transforming protein of cervical-cancer associated human papillomavirus type-18 (hpv18). Virus Research, 36 (1), 1-13. doi: 10.1016/0168-1702(94)00101-H
Papillomavirus Capsid Binding and Uptake by Cells From Different Tissues and Species
Muller, Martin, Gissmann, Lutz, Cristiano, Richard J., Sun, Xiao-Yi, Frazer, Ian H., Jenson, A. Bennet, Alonso, Angel, Zentgraf, Hanswalter and Zhou, Jian (1995). Papillomavirus Capsid Binding and Uptake by Cells From Different Tissues and Species. Journal of Virology, 69 (2), 948-954. doi: 10.1128/jvi.69.2.948-954.1995
Routine HIV testing before surgery
Selvey, L., Hogan, P., Frazer, I. H., Smithers, M. and Robinson, D. (1995). Routine HIV testing before surgery. Australian Journal of Public Health, 19 (1), 107-108.
Fernando, Germain J. P., Stenzel, Deborah J., Tindle, Robert W., Merza, Malik S., Morein, Bror and Frazer, Ian H. (1995) Peptide polymerisation facilitates incorporation into ISCOMs and increases antigen-specific IgG2a production. Vaccine, 13 15: 1460-1467. doi:10.1016/0264-410X(95)00029-Z
Selvey, L. A., Dunn, L. A., Tindle, R. W., Park, D. S. and Frazer, I. H. (1994). Human Papillomavirus (Hpv) Type-18 E7 Protein Is a Short-Lived Steroid-Inducible Phosphoprotein in Hpv-Transformed Cell-Lines. Journal of General Virology, 75 (7), 1647-1653. doi: 10.1099/0022-1317-75-7-1647
Thomas, S, Brennan, J, Martel, G, Frazer, I, Montesano, R, Sidransky, D and Hollstein, M (1994). Mutations in the Conserved Regions of P53 Are Infrequent in Betel-Associated Oral Cancers From Papua-New-Guinea. Cancer Research, 54 (13), 3588-3593.
Zhou, Jian, Sun, Xiao-Yi, Louis, Kylie and Frazer, Ian H. (1994). Interaction of Human Papillomavirus (Hpv) Type-16 Capsid Proteins with Hpv Dna Requires An Intact L2 N-Terminal Sequence. Journal of Virology, 68 (2), 619-625.
Donor-specific immune response after aortic valve allografting in the rat
Zhao, Xiao-ming, Green, Marjorie, Frazer, Ian H., Hogan, Patrick and O'Brien, Mark F. (1994). Donor-specific immune response after aortic valve allografting in the rat. The Annals of Thoracic Surgery, 57 (5), 1158-1163. doi: 10.1016/0003-4975(94)91347-1
Tindle, R. W. and Frazer, I. H. (1994). Immune response to human papillomaviruses and the prospects for human papillomavirus-specific immunisation. Current Topics in Microbiology and Immunology, 186, 217-253. doi: 10.1007/978-3-642-78487-3_12
Martel, G., Montesano, R. and Hollstein, M. (1994). Mutations in the Conserved Regions of p53 Are Infrequent in Betel-associated Oral Cancers from Papua New Guinea. Cancer Research, 54 (13), 3588-3593.
Sterile Immunity - General Discussion-I
Liew, FY, Frazer, I, Moss, DJ, Doherty, PC, Wettstein, FO, Beverley, Pcl, Milich, DR, Rickinson, AB and Arrand, JR (1994). Sterile Immunity - General Discussion-I. Vaccines Against Virally Induced Cancers, 187, 45-46.
Frazer, I (1994). Symposium On Vaccines Against Virally Induced Cancers, Held At the Ciba-Foundation, London, 15-17-March-1994 - Introduction. Vaccines Against Virally Induced Cancers, 187, 1-3.
Vaccines Against Virally Induced Cancers - Final Discussion
Frazer, IH, Stanley, M, Campo, MS, Galloway, DA, Melief, Cjm, Doherty, PC, Eisenberg, L, Greenberg, P, Wettstein, FO, Levitsky, H, Moss, DJ, Arrand, JP, Rickinson, AB, Chen, L, Cresswell, P and Parham, P (1994). Vaccines Against Virally Induced Cancers - Final Discussion. Vaccines Against Virally Induced Cancers, 187, 261-270.
Park, DS, Selvey, LA, Kelsall, SR and Frazer, IH (1993). Human Papillomavirus Type-16 E6, E7 and L1 and Type-18 E7 Proteins Produced by Recombinant Baculoviruses. Journal of Virological Methods, 45 (3), 303-318. doi: 10.1016/0166-0934(93)90115-8
Frazer, I (1993). Untitled - Reply. Australian & New Zealand Journal of Obstetrics & Gynaecology, 33 (4), 451-451.
Glycosylation of Human Papillomavirus Type-16 L1 Protein
Zhou, J, Sun, XY and Frazer, IH (1993). Glycosylation of Human Papillomavirus Type-16 L1 Protein. Virology, 194 (1), 210-218. doi: 10.1006/viro.1993.1251
Mendelson, J, Ferenczy, A, Arseneau, J, Dascal, A, Eiley, S, Frazer, I, Kennedy, L, Oconnor, D, Bouchard, C, Fortier, M, Champoux, F, Tio, TT, Huisman, WM, Vandeberg, GM, Stolz, E, Syrjanen, K, Syrjanen, S, Paavonen, J, Aho, M, Nieminen, P, Vesterinen, E, Leminen, A, Rinne, E, Boland, K, Fauchere, S, Holmstrom, S, Hammerjensen, R, Walker, M, Ryff, JC ... Schlenker, R (1993). Randomized Placebo-Controlled Double-Blind Combined Therapy with Laser-Surgery and Systemic Interferon-Alpha-2A in the Treatment of Anogenital Condylomata Acuminatum. Journal of Infectious Diseases, 167 (4), 824-829.
Synthesis and Assembly of Infectious Bovine Papillomavirus Particles Invitro
Zhou, J, Stenzel, DJ, Sun, XY and Frazer, IH (1993). Synthesis and Assembly of Infectious Bovine Papillomavirus Particles Invitro. Journal of General Virology, 74 (4), 763-768. doi: 10.1099/0022-1317-74-4-763
Transmission of Human Papillomaviruses From Mother to Child
Fredericks, BD, Balkin, A, Daniel, HW, Schonrock, J, Ward, B and Frazer, IH (1993). Transmission of Human Papillomaviruses From Mother to Child. Australian & New Zealand Journal of Obstetrics & Gynaecology, 33 (1), 30-32. doi: 10.1111/j.1479-828X.1993.tb02047.x
Frazer, I. H., Leonard, J. H., Schonrock, J., Wright, R. G. and Kearsley, J. H. (1993). HPV DNA in oropharyngeal squamous cell cancers: Comparison of results from four DNA detection methods. Pathology, 25 (2), 138-143. doi: 10.3109/00313029309084788
Localized granulomatous epiglottitis
Hetterich, F., Suthers, M., Wells, J., Coman, W., Frazer, I. and Hogan, P. (1993). Localized granulomatous epiglottitis. Australian Journal of Otolaryngology, 1 (4), 369-371.
Hare, A. and Frazer, I. (1993). To the editor [3]. Australian and New Zealand Journal of Obstetrics and Gynaecology, 33 (4)
Tindle, Robert W., Murray, Barbara, Herd, Karen, Kennedy, Lynn, O'Connor, Dan T., Fernando, Germain J. P. and Frazer, Ian H. (1992). Humoral immune response to the E7 open reading frame protein of human papillomavirus genotype 16 in subjects with anogenital papillomavirus infection and controls. Immunology and Infections Diseases, 2, 223-228.
Zhou, J, Sun, XY, Davies, H, Crawford, L, Park, D and Frazer, IH (1992). Definition of Linear Antigenic Regions of the Hpv16 L1-Capsid Protein Using Synthetic Virion-Like Particles. Virology, 189 (2), 592-599. doi: 10.1016/0042-6822(92)90582-A
The vaccinia virus K2L gene encodes a serine protease inhibitor which inhibits cell-cell fusion
Zhou, J., Sun, X. Y., Fernando, G. J. P. and Frazer, I. H. (1992). The vaccinia virus K2L gene encodes a serine protease inhibitor which inhibits cell-cell fusion. Virology, 189 (2), 678-686. doi: 10.1016/0042-6822(92)90591-C
Human Papillomaviruses in Normal Oral-Mucosa - a Comparison of Methods for Sample Collection
Lawton, G, Thomas, S, Schonrock, J, Monsour, F and Frazer, I (1992). Human Papillomaviruses in Normal Oral-Mucosa - a Comparison of Methods for Sample Collection. Journal of Oral Pathology & Medicine, 21 (6), 265-269. doi: 10.1111/j.1600-0714.1992.tb01008.x
An Elisa Capture Assay for the E7 Transforming Proteins of Hpv16 and Hpv18
Selvey, L. A., Dunn, L. A., Murray, B., Tindle, R. W. and Frazer, I. H. (1992). An Elisa Capture Assay for the E7 Transforming Proteins of Hpv16 and Hpv18. Journal of Virological Methods, 37 (2), 119-128. doi: 10.1016/0166-0934(92)90039-G
Identification of the Nuclear-Localization Signal of Human Papillomavirus Type-16 L1-Protein
Zhou, J, Doorbar, J, Sun, XY, Crawford, LV, McLean, CS and Frazer, IH (1991). Identification of the Nuclear-Localization Signal of Human Papillomavirus Type-16 L1-Protein. Virology, 185 (2), 625-632. doi: 10.1016/0042-6822(91)90533-H
Zhou, J, Sun, XY, Stenzel, DJ and Frazer, IH (1991). Expression of Vaccinia Recombinant Hpv 16 L1 and L2 Orf Proteins in Epithelial-Cells Is Sufficient for Assembly of Hpv Virion-Like Particles. Virology, 185 (1), 251-257. doi: 10.1016/0042-6822(91)90772-4
The Hygromycin-Resistance-Encoding Gene as a Selection Marker for Vaccinia Virus Recombinants
Zhou, J, Crawford, L, Sun, XY and Frazer, IH (1991). The Hygromycin-Resistance-Encoding Gene as a Selection Marker for Vaccinia Virus Recombinants. Gene, 107 (2), 307-312. doi: 10.1016/0378-1119(91)90331-5
Zinc deficiency and the short bowel syndrome
Terry, S. I., Ford, M. J., Sircus, W., Suttle, N. F., Frazer, I. and Munro, J. F. (1991). Zinc deficiency and the short bowel syndrome. Journal of Trace Elements in Experimental Medicine, 4 (2), 85-88.
Tindle, Robert W., Fernando, Germain J. P., Sterling, Jane C. and Frazer, Ian H. (1991). A 'public' T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes. Proceedings of the National Academy of Sciences of the United States of America, 88 (13), 5887-5891. doi: 10.1073/pnas.88.13.5887
Identification of B-Epitopes in the Human Papillomavirus-18 E7 Open Reading Frame Protein
Selvey, L. A., Tindle, R. W., Geysen, H. M., Haller, C. J., Smith, J. A. and Frazer, I. H. (1990). Identification of B-Epitopes in the Human Papillomavirus-18 E7 Open Reading Frame Protein. Journal of Immunology, 145 (9), 3105-3110.
Immunology of Anogenital Human Papillomavirus (Hpv) Infection
Tindle, R. W. and Frazer, I. H. (1990). Immunology of Anogenital Human Papillomavirus (Hpv) Infection. Australian & New Zealand Journal of Obstetrics & Gynaecology, 30 (4), 370-375. doi: 10.1111/j.1479-828X.1990.tb02033.x
Major Population Differences in T-Cell Response to a Malaria Sporozoite Vaccine Candidate
Zevering, Y, Houghten, RA, Frazer, IH and Good, MF (1990). Major Population Differences in T-Cell Response to a Malaria Sporozoite Vaccine Candidate. International Immunology, 2 (10), 945-955. doi: 10.1093/intimm/2.10.945
Smillie, Anne E., Tindle, Robert W., O'Connor, Dan T., Kennedy, Lynn and Frazer, Ian H. (1990). Humoral response to human papillomavirus genotype 16 and 18 open reading frame antigens in subjects with anogenital papillomavirus infection and controls. Immunology & Infections Diseases, 1, 13-17.
Tindle, R. W., Zhou, W. D., Saul, A. and Frazer, I. H. (1990) The molecular specificity of linear B-epitopes in the E7 open reading frame protein of human papillomavirus 16 defined by monoclonal antibodies. Peptide Research, 3 4: 162-166.
Identification of B Epitopes in Human Papillomavirus Type-16 E7 Open Reading Frame Protein
Tindle, R. W., Smith, J. A., Geysen, H. M., Selvey, L. A. and Frazer, I. H. (1990). Identification of B Epitopes in Human Papillomavirus Type-16 E7 Open Reading Frame Protein. Journal of General Virology, 71 (6), 1347-1354. doi: 10.1099/0022-1317-71-6-1347
Chalmers, AH, Hare, C, Woolley, G and Frazer, IH (1990). Lymphocyte Ectoenzyme Activity Compared in Healthy-Persons and Patients Seropositive to or At High-Risk of Hiv-Infection. Immunology and Cell Biology, 68 (2), 81-85. doi: 10.1038/icb.1990.12
A NEONATALLY TOLERANT MOUSE MODEL TO ASSESS PATHOGENICITY OF HUMAN AUTOANTIBODIES
MUNDLOS, S, MACKAY, IR, FRAZER, IH and ROWLEY, M (1990). A NEONATALLY TOLERANT MOUSE MODEL TO ASSESS PATHOGENICITY OF HUMAN AUTOANTIBODIES. Journal of Immunological Methods, 127 (2), 279-284. doi: 10.1016/0022-1759(90)90079-B
Immunology of Papillomavirus Infection of the Human Anogenital Epithelium
Tindle, R. W., Park, D. and Frazer, I. H. (1990) Immunology of Papillomavirus Infection of the Human Anogenital Epithelium. Journal of Gynecologic Surgery, 6 1: 11-21. doi:10.1089/gyn.1990.6.11
Field, M, Tate, J, Kunze, H and Frazer, IH (1989). Cerebral-Dysfunction with Evidence of Cerebral Hiv Infection Amongst Asymptomatic Hiv Seropositive Subjects. Australian and New Zealand Journal of Medicine, 19 (6), 694-699. doi: 10.1111/j.1445-5994.1989.tb00337.x
RENOUF, JA, WOOD, A, FRAZER, IH, THONG, YH and CHALMERS, AH (1989). DEPRESSED ACTIVITIES OF PURINE ENZYMES IN LYMPHOCYTES OF PATIENTS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS. Clinical Chemistry, 35 (7), 1478-1481.
Selvey, L., Buntine, D.W., Kennedy, L. and Frazer, I.H. (1989). Male partners of women with genital human papillomavirus infection - an assessment of colposcopic abnormalities by histological examination and human papillomavirus hybridization. Medical Journal of Australia, 150 (9), 479-&. doi: 10.5694/j.1326-5377.1989.tb136590.x
Wood, G, Whitby, M, Hogan, P and Frazer, I (1989). Foscarnet Infusion At Home. Lancet, 1 (8630), 156-156.
A Biometrical View On Normal Values of Cd4 and Cd8 Lymphocyte Counts in Peripheral-Blood
Zachar, V, Mikulecky, M, Mayer, V, Mackay, I and Frazer, I (1988). A Biometrical View On Normal Values of Cd4 and Cd8 Lymphocyte Counts in Peripheral-Blood. Pathology, 20 (4), 358-360. doi: 10.3109/00313028809085219
Frazer, I.H., McCamish, M., Hay, I. and North, P. (1988). Influence of human immunodeficiency virus-antibody testing on sexual-behavior in a high-risk population from a low-risk city. Medical Journal of Australia, 149 (7), 365-368. doi: 10.5694/j.1326-5377.1988.tb120670.x
Human papillomavirus - a study of male sexual partners
Kennedy, L., Buntine, D.W., Oconnor, D. and Frazer, I.H. (1988). Human papillomavirus - a study of male sexual partners. Medical Journal of Australia, 149 (6), 309-311.
Some Adverse Reactions to Allopurinol May Be Mediated by Lymphocyte-Reactivity to Oxypurinol
Emmerson, BT, Hazelton, RA and Frazer, IH (1988). Some Adverse Reactions to Allopurinol May Be Mediated by Lymphocyte-Reactivity to Oxypurinol. Arthritis and Rheumatism, 31 (3), 436-440. doi: 10.1002/art.1780310318
AIDS-associated psoriasis responds to azidothymidine
Feeney, G.F. and Frazer, I. (1988). AIDS-associated psoriasis responds to azidothymidine. Medical Journal of Australia, 148 (3), 155-155.
Frazer, I.H., Jones, B., Dimitrakakis, M. and Mackay, I.R. (1987). Intramuscular versus low-dose intradermal hepatitis B vaccine. Assessment by humoral and cellular immune response to hepatitis B surface antigen. Medical Journal of Australia, 146 (5), 242-245.
Frazer, IH, Jordan, TW, Collins, EC, Andrews, P and Mackay, IR (1987). Antibody to Liver Membrane-Antigens in Chronic Active Hepatitis .4. Exclusion of Specific Reactivity to Polypeptides and Glycolipids by Immunoblotting. Hepatology, 7 (1), 4-10. doi: 10.1002/hep.1840070103
Immunoregulatory defects associated with infection with the AIDS virus, HTLV-III
Crapper, R. M., Frazer, I. H., Mackay, I. R., Iscaro, A. and Bradford, D. L. (1987). Immunoregulatory defects associated with infection with the AIDS virus, HTLV-III. Concepts in immunopathology, 4, 243-260.
2nd International Conference on the Acquired Immune Deficiency Syndrome
Frazer, I.H. and Mulhall, B.P. (1986). 2nd International Conference on the Acquired Immune Deficiency Syndrome. Medical Journal of Australia, 145 (10), 524-529. doi: 10.5694/j.1326-5377.1986.tb139458.x
Frazer, IH, Mackay, IR, Crapper, RM, Jones, B, Gust, ID, Sarngadharan, MG, Campbell, DC and Ungar, B (1986). Immunological Abnormalities in Asymptomatic Homosexual Men - Correlation with Antibody to Htlv-Iii and Sequential-Changes Over 2 Years. Quarterly Journal of Medicine, 61 (234), 921-933. doi: 10.1093/oxfordjournals.qjmed.a068051
Frazer, I.H, Crapper, R.M, Medley, G, Brown, T.C and Mackay, I.R (1986). ASSOCIATION BETWEEN ANORECTAL DYSPLASIA, HUMAN PAPILLOMAVIRUS, AND HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HOMOSEXUAL MEN. The Lancet, 328 (8508), 657-660. doi: 10.1016/S0140-6736(86)90168-6
Auto-Epitopes and Autoimmune-Diseases
Mackay, IR, Frazer, IH, McNeilage, LJ and Whittingham, S (1986). Auto-Epitopes and Autoimmune-Diseases. Annals of the New York Academy of Sciences, 475 (1 Autoimmunity), 59-65. doi: 10.1111/j.1749-6632.1986.tb20856.x
Demoerloose, PA, Frazer, IH, Sewell, WA, Collins, EJ and Mackay, IR (1986). Cell-Mediated-Immunity to Hepatitis-B Virus-Antigens in Mice - Correlation of Invivo and Invitro Assays. Clinical and Experimental Immunology, 64 (2), 285-294.
Prevalence of antibody to HTLV-III in homosexual men in Melbourne
Frazer, I.H., Mackay, I.R., Crapper, R.M., Gust, I.D. and Sarngadharan, M.G. (1986). Prevalence of antibody to HTLV-III in homosexual men in Melbourne. Medical Journal of Australia, 144 (5), 276-276.
A Rapid Micromethod for the Enumeration of T-Cell Subsets in Blood by Epifluorescence Microscopy
Frazer, IH, Mackay, IR and Battye, F (1986). A Rapid Micromethod for the Enumeration of T-Cell Subsets in Blood by Epifluorescence Microscopy. Methods in Enzymology, 121 (C), 748-758. doi: 10.1016/0076-6879(86)21073-3
Crapper, RM, Bhathal, PS, Mackay, IR and Frazer, IH (1986). Acute Autoimmune Hepatitis. Digestion, 34 (3), 216-225. doi: 10.1159/000199332
IDIOPATHIC NEUTROPENIA IN HOMOSEXUAL MEN
Minchinton, R. M., Frazer, I., Van Der Lelie, J., Lange, J. M.A., Goudsmit, J., Danner, S. A., Van der Plas-Van Dalen, C. M., Vos, J. J.E. and Von Dem Borne, A.E.G.Kr (1985). IDIOPATHIC NEUTROPENIA IN HOMOSEXUAL MEN. The Lancet, 325 (8434), 936-937. doi: 10.1016/S0140-6736(85)91716-7
1st International Conference on the Acquired Immunodeficiency Syndrome
Frazer, I.H. and Donald, K.J. (1985). 1st International Conference on the Acquired Immunodeficiency Syndrome. Medical Journal of Australia, 143 (1), 31-34. doi: 10.5694/j.1326-5377.1985.tb122765.x
A Graphical Presentation of Counts of Lymphocyte-T Subpopulations and Th-Ts Ratios
Frazer, IH and Mackay, IR (1985). A Graphical Presentation of Counts of Lymphocyte-T Subpopulations and Th-Ts Ratios. Pathology, 17 (1), 62-63. doi: 10.3109/00313028509063726
Absence of Autoimmune Serological Reactions in Chronic Non-A, Non-B Viral-Hepatitis
Mackay, IR, Frazer, IH, Toh, BH, Pedersen, JS and Alter, HJ (1985). Absence of Autoimmune Serological Reactions in Chronic Non-A, Non-B Viral-Hepatitis. Clinical and Experimental Immunology, 61 (1), 39-43.
Cunningham, AL, Mackay, IR, Frazer, IH, Brown, C, Pedersen, JS, Toh, BH, Tait, BD and Clarke, FM (1985). Antibody to G-Actin in Different Categories of Alcoholic Liver-Disease - Quantification by An Elisa and Significance for Alcoholic Cirrhosis. Clinical Immunology and Immunopathology, 34 (2), 158-164. doi: 10.1016/0090-1229(85)90020-0
Frazer, IH, Collins, EJ, Fox, JS, Jones, B, Oliphant, RC and Mackay, IR (1985). Assessment of Delayed-Type Hypersensitivity in Man - a Comparison of the Multitest and Conventional Intradermal Injection of 6 Antigens. Clinical Immunology and Immunopathology, 35 (2), 182-190. doi: 10.1016/0090-1229(85)90064-9
Idiopathic Neutropenia in Homosexual Men
Minchinton, RM and Frazer, I (1985). Idiopathic Neutropenia in Homosexual Men. Lancet, 1 (8434), 936-936.
Frazer, IH, Mackay, IR, Jordan, TW, Whittingham, S and Marzuki, S (1985). Reactivity of Anti-Mitochondrial Autoantibodies in Primary Biliary-Cirrhosis - Definition of 2 Novel Mitochondrial Polypeptide Auto-Antigens. Journal of Immunology, 135 (3), 1739-1745.
Frazer, IH, Mackay, IR, Bell, J and Becker, G (1985). The Cellular Infiltrate in the Liver in Autoimmune Chronic Active Hepatitis - Analysis with Monoclonal-Antibodies. Liver, 5 (3), 162-172. doi: 10.1111/j.1600-0676.1985.tb00232.x
Frazer, IH and Mackay, IR (1984). Antibodies to Liver-Cell Membrane-Antigens in Chronic Active Hepatitis (Cah) .3. Partial Characterization of the Liver-Cell Membrane-Antigens and Comparison of Reactivities in Sera From Patients with Various Liver-Diseases. Clinical and Experimental Immunology, 57 (2), 429-437.
Antibody to human T cell leukaemia virus type III in Australian homosexual men with lymphadenopathy
Frazer, I.H., Sarngadharan, M.G., Mackay, I.R. and Gallo, R.C. (1984). Antibody to human T cell leukaemia virus type III in Australian homosexual men with lymphadenopathy. Medical Journal of Australia, 141 (5), 274-276.
Autoantibodies, Sheep Cell Agglutinins and Anti-Albumin Antibodies in Alcoholic Liver-Disease
Macgeorge, J, Frazer, IH and Cunningham, A (1984). Autoantibodies, Sheep Cell Agglutinins and Anti-Albumin Antibodies in Alcoholic Liver-Disease. Journal of Clinical & Laboratory Immunology, 13 (1), 21-24.
Frazer, IH and Mackay, IR (1984). Immune-Responses to Liver-Specific Lipoprotein and Liver Membrane Antigen - a Tabular Interpretative Review. Journal of Clinical & Laboratory Immunology, 14 (4), 165-167.
The 1984 International Symposium on Viral Hepatitis
Frazer, I.H., Gust, I.D. and Mackay, I.R. (1984). The 1984 International Symposium on Viral Hepatitis. Medical Journal of Australia, 140 (12), 712-714. doi: 10.5694/j.1326-5377.1984.tb108359.x
LONG-TERM EFFICACY OF FENFLURAMINE IN TREATMENT OF OBESITY
Douglas, J. G., Preston, P. G., Haslett, C., Gough, J., Frazer, I., Chalmers, S. R. and Munro, J. F. (1983). LONG-TERM EFFICACY OF FENFLURAMINE IN TREATMENT OF OBESITY. The Lancet, 321 (8321), 384-386. doi: 10.1016/S0140-6736(83)91501-5
A Rapid Micromethod for Evaluating T-Cell Subsets in Blood Using Monoclonal Antisera
Frazer, IH and Mackay, IR (1983). A Rapid Micromethod for Evaluating T-Cell Subsets in Blood Using Monoclonal Antisera. Journal of Immunological Methods, 57 (1-3), 137-144. doi: 10.1016/0022-1759(83)90071-6
Frazer, IH, Kronborg, IJ and Mackay, IR (1983). Antibodies to Liver Membrane-Antigens in Chronic Active Hepatitis (Cah) .2. Specificity for Autoimmune Cah. Clinical and Experimental Immunology, 54 (1), 213-218.
Fundamental and applied aspects of rheumatoid arthritis
Frazer, I.H. and Mackay, I.R. (1983). Fundamental and applied aspects of rheumatoid arthritis. Medical Journal of Australia, 1 (11), 516-518.
Long-Term Efficacy of Fenfluramine in Treatment of Obesity
Douglas, JG, Preston, PG, Haslett, C, Gough, J, Frazer, I, Chalmers, SR and Munro, JF (1983). Long-Term Efficacy of Fenfluramine in Treatment of Obesity. Lancet, 1 (8321), 384-386.
Pleuroperitoneal effusion without ascites
Frazer, I.H., Lichtenstein, M. and Andrews, J.T. (1983). Pleuroperitoneal effusion without ascites. Medical Journal of Australia, 2 (10), 520-522.
Kronborg, IJ, Frazer, IH and Mackay, IR (1982). Autoantibodies to Liver Antigens in Chronic Liver-Disease .1. a Radioimmunoassay for Antibody to Liver Membrane-Antigens. Journal of Clinical & Laboratory Immunology, 9 (3), 207-211.
Frazer, IH and Mackay, IR (1982). Lymphocyte-T Sub-Populations Defined by 2 Sets of Monoclonal-Antibodies in Chronic Active Hepatitis and Systemic Lupus-Erythematosus. Clinical and Experimental Immunology, 50 (1), 107-114.
Burns, GF, Librach, CL, Frazer, IH, Kronborg, IJ and Mackay, IR (1982). Spontaneous Reverse Hemolytic Plaque-Formation .3. Monocyte-Mediated Suppression of Elevated Plaque-Formation in Autoimmune-Disease. Clinical Immunology and Immunopathology, 24 (3), 386-395. doi: 10.1016/0090-1229(82)90009-5
Acute haemolysis and renal failure after nomifensine overdosage
Prescott, L. F., Illingworth, R. N., Critchley, J. A. J. H., Frazer, I. and Stirling, M. L. (1980). Acute haemolysis and renal failure after nomifensine overdosage. BMJ, 281 (6252), 1392-1393. doi: 10.1136/bmj.281.6252.1392-a
Is infusion phlebitis preventable?
Frazer, I. H., Eke, N. and Laing, M. S. (1977). Is infusion phlebitis preventable?. BMJ, 2 (6081), 232-232. doi: 10.1136/bmj.2.6081.232
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
Wright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289
Tsutsumi, Tamao, Shah, Alok, Lam, Lisa M T, Schlebusch, Sanmarie, Krueger, Annika, Frazer, Ian, Hugenholtz, Phil, Soyer, H Peter, Morrison, Mark, Hill, Michelle, Sedman, Jacqueline and Ismail, Ashraf (2019). 2125. Staphylococcus Species Identification by Fourier Transform Infrared (FTIR) Spectroscopic Techniques: A Cross-Lab Study. IDWeek 2019, Washington, DC, United States, 2-6 October 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ofid/ofz360.1805
Zeng, Z., Cruz, J. G., Pett, N., Veitch, M., Frazer, I. H. and Wells, J. W. (2019). The involvement of IFN-gamma and CXCR3 in the CD8(+) T-cell-mediated regression of squamous cell carcinoma. 17th International Congress of Immunology (IUIS), Beijing, Peoples R China, 19-23 October 2019. Weinheim, Germany: Wiley.
Bridge, Jennifer A., Overgaard, Nana H., Steptoe, Raymond J., Frazer, Ian H. and Wells, James W. (2016). Altering the balance between immune activation versus regulation in the skin to promote CD8 T-cell activity within epithelial cancers. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, La, United States, Apr 16-20, 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3999
CD4(+)CD8(+) double-positive T-cells regulate CD8(+) single-positive T cell function in the skin
Cruz, Gonzalez J. L., Overgaard, N. H., Bridge, J. A., Jung, J. -W, He, J., Nel, H. J., Watson, K., Frazer, I. H., La Gruta, N. L., Steptoe, R. J. and Wells, J. W. (2016). CD4(+)CD8(+) double-positive T-cells regulate CD8(+) single-positive T cell function in the skin. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Tuong, Z. K. , Kuo, P. , Sinha, R. , Tolley, L. and Frazer, I. H. (2016). Exhausted T cell signature enriched in HPV16 E7 mouse model and cervical intraepithelial neoplasia grade III. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley-VCH. doi: 10.1002/eji.201670200
Immunotherapy for persisting viral infection and associated cancer
Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Mattarollo, Stephen, Leggatt, Graham, Wells, James, Lambert, Paul and Frazer, Ian H. (2016). Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-A064
Novel regulators of CD8 T-cell functions in the skin
Bridge, Jennifer A., Overgaard, Nana H., Cruz, Jazmina L. G., Veitch, Margaret, Frazer, Ian H., Steptoe, Raymond J. and Wells, James W. (2016). Novel regulators of CD8 T-cell functions in the skin. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular and Experimental Pathology Society of Australasia (MEPSA), Melbourne, Australia , November 7–9, 2016. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/wrr.12489
Novel regulators of CD8(+) T-cell functions in the skin
Bridge, J. A., Overgaard, N. H., Cruz, J. L. G., Veitch, M., Frazer, I. H., Steptoe, R. J. and Wells, J. W. (2016). Novel regulators of CD8(+) T-cell functions in the skin. International Congress of Immunology (ICI), Melbourne, Australia, 21-16 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Kuo, P., Tuong, K., Mattarollo, S. and Frazer, I. (2016). Pre-malignant immune suppressive environment is dependent on HPV16E7-Rb interaction induced epithelium hyperplasia. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Rapamycin, but not tacrolimus, promotes Cd8 memory T-cell differentiation and function in the skin
Jung, Ji-Won, Simpson, Fiona, Frazer, Ian H. and Wells, James W. (2016). Rapamycin, but not tacrolimus, promotes Cd8 memory T-cell differentiation and function in the skin. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA), Melbourne Exhibition and Convention Centre, Melbourne, Australia, 7-9 November 2016. Hoboken, NJ United States: Wiley-Blackwell Publishing.
Jung, Ji-Won, Taylor, Paul J., Simpson, Fiona, Frazer, Ian H. and Wells, James W. (2016). The impact of rapamycin and tacrolimus treatment on resident CD8+T-cell populations in cutaneous squamous cell carcinoma. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-B055
Trafficking of E7 specific CD8 T cells from the host to hyperproliferative graft
Jazayeri, S. D. and Frazer, I. H. (2016). Trafficking of E7 specific CD8 T cells from the host to hyperproliferative graft. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Uncovering novel regulators of CD8(+) T-cell functions in the skin
Bridge, J. A., Overgaard, N. H., Cruz, J. L., Veitch, M., Frazer, I. H., Steptoe, R. J. and Wells, J. W. (2016). Uncovering novel regulators of CD8(+) T-cell functions in the skin. Asia-Pacific Combined Dermatology Research Conference, Noosa, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/ajd.12584
Frazer, I. H. (2015). The future of HPV vaccination. RCOG World Congress 2015, Brisbane, Queensland, Australia, 12-15 April. HOBOKEN: WILEY-BLACKWELL.
Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo
Gatica-Andrades, M. D., Nguyen, T. T. K., Schultz, T. E., Wyer, O. J. K., Melo-Bolivar, J., Walker, M. J., Frazer, I. H., Barnett, T. C. and Blumenthal, A. (2014). Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, 1-4 December 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12406
Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin
Leggatt, Graham, Mattarollo, Stephen, Yong, Michelle, Nissen, Michael and Frazer, Ian (2013). Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin. 100th Annual Meeting of the American Association of Immunologists, Honolulu, Hawaii, 03-07 May 2013. Bethesda, MD United States: American Association of Immunologists.
Cancer Immunotherapy in the 21St Century
Frazer, I (2012). Cancer Immunotherapy in the 21St Century. RACP Future Directions in Health Congress 2012, Brisbane, Queensland, Australia, 6-9 May 2012. Richmond, VIC 3121 Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1445-5994.2012.02779.x
Expression of HPV16-E7 oncoprotein in skin exacerbates the contact hypersensitivity response to DNCB
Bergot, A. S., Le Tran, S., Mittal, D., Grimbaldeston, M. A. and Frazer, I. H. (2012). Expression of HPV16-E7 oncoprotein in skin exacerbates the contact hypersensitivity response to DNCB. European Congress of Immunology, Glasgow Scotland, 5-8 September 2012. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12002
Fernando, Germain J. P., Chen, XianFeng, Prow, Tarl, Crichton, Michael, Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2009). A novel Nanopatch that directly delivers influenza vaccine painlessly to antigen presenting cells in the skin and affords high dose reduction. Third International Conference on Modern Vaccines Adjuvants & Delivery Systems, Vienna, Austria, 28-30 October 2009.
Jardine, D., Lu, J., Palmer, C., Pang, J., Chuah, J. and Frazer, I. (2009). A phase 1b multicentre study of HPV6 L1 virus-like particles as adjunct immunotherapy for anogenital warts. Australasian Sexual Health Conference 2009, Gold Coast, Queensland, Australia, 7 - 9 September 2009. COLLINGWOOD: CSIRO Publishing.
Controlling Hpv Associated Disease: a Glass Half Full?
Frazer, I. (2009). Controlling Hpv Associated Disease: a Glass Half Full?. COLLINGWOOD: CSIRO PUBLISHING.
Frazer, Ian H. (2009). Fossilised knowledge? Libraries as repositories of knowledge in biomedical research in the cyberspace era. Positioning the Profession: the Tenth International Congress on Medical Librarianship, Brisbane, Australia, August 31-September 4, 2009.
Leggatt, G. R., Zhong, J., Mattarollo, S., Liu, X., De Kluyver, R., Fiorenza, S., Zhou, J., Hadis, U., Warif, N. A., Rahimpour, A., Broom, J. and Frazer, I. H. (2009). Immunotherapy for skin cancer. 6th Annual Scientific Meeting, Australasian Society for Dermatology Research, Surfers Paradise, QLD, Australia, 20-21 May 2009. Baltimore, MD, U.S.A.: Nature Publishing Group. doi: 10.1038/jid.2009.333
Garland, S., Park, S. N., Ngan, H. Y S, Frazer, I., Tay, E. H., Chen, C. J., Bhatla, N., Pitts, M., Shin, H. R., Konno, R., Smith, J., Pagliusi, S. and Park, J. S. (2008). The need for public education on HPV and cervical cancer prevention in Asia. Opinions of experts at the AOGIN Conference. doi: 10.1016/j.vaccine.2008.07.077
Limitations of conventional bending rigs to simulate pipelay processes involving plastic deformation
Vennemann, Olav, Jackson, Adam and Frazer, Ian (2007). Limitations of conventional bending rigs to simulate pipelay processes involving plastic deformation. 17th International Offshore and Polar Engineering Conference (ISOPE 2007), Lisbon Portugal, 01-06 July 2007. Mountain View, CA United States: International Society of Offshore and Polar Engineers.
Advances in prevention of cervical cancer and other human papillomavirus-related diseases
Frazer, Ian H., Cox, J. Thomas, Mayeaux Jr., Edward John, Franco, Eduardo L., Moscicki, Anna-Barbara, Palefsky, Joel M., Ferris, Daron G., Ferenczy, Alex S. and Villa, Luisa L. (2006). Advances in prevention of cervical cancer and other human papillomavirus-related diseases. doi: 10.1097/01.inf.0000196485.86376.46
Not Perforin or Fas-L, is Required for Killing Keratinocytes In Vitro and In Vivo
deKluyver, R. L., Morritz, L., Frazer, I. H. and Lambert, P. F. (2005). Not Perforin or Fas-L, is Required for Killing Keratinocytes In Vitro and In Vivo. 2nd Annual Scientific Meeting of the Australasian Society for Dermatology Research, Perth, Australia, May 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.0022-202X.2005.23947.x
Frazer, IH (2004). Human papillomavirus. Conference on Vaccines, Prevention and Public Health, Washington Dc, Nov 25-27, 2002. WASHINGTON: PAN AMERICAN HEALTH ORGANIZATION.
Immunotherapy for HPV associated pre-cancer
Frazer, Ian H., Leggatt, G. J., Matsumoto, K., De Kluyver, R., Quinn, M., Nicklin, J., Tan, J., Perrin, L., Ng, P., O'Connor, V., White, O., Wendt, N., Martin, J., Mitchelll, S.V., McKenzie, A., Crowley, J., Edwards, S. and Maher, D. (2003). Immunotherapy for HPV associated pre-cancer. Cancer Vaccine Collaborative 2002, Multiple locations, September 30 - October 1 2002. The Academy of Cancer Immunology.
Frazer, IH (2002). Wart and hepatitis vaccines. 17th World Congress on Fertility and Sterility, Melbourne Australia, Nov 25-30, 2001. LANCASTER: PARTHENON PUBLISHING GROUP LTD.
Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity
Saito, J., Kanzaki, H., Leggatt, G. and Frazer, I. (2001). Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity. 53rd Annual Congress of the Japan Society of Obstetrics and Gynecology, Sapporo, Japan, 12-15 May 2001. 40128 BOLOGNA: Medimond S R L.
Quantitative trait loci underlying variation in blood cell concentrations
Evans, D. M., Zhu, G., Frazer, I. H. and Martin, N. G. (2001). Quantitative trait loci underlying variation in blood cell concentrations. It Runs in the Family: Twins and Families in Biome, Melbourne, Australia, 6-7 April, 2001. Cambridge, MA: Cell Press.
Towards the development of edible vaccines for human papillomavirus in bananas
Miller, J, Becker, D, Dugdale, B, Harding, R, Aaskov, J, Frazer, I and Dale, J (2001). Towards the development of edible vaccines for human papillomavirus in bananas. OECD Workshop on Molecular Farming, Grande Motte France, Sep 03-06, 2000. PARIS: INST NATL RECHERCHE AGRONOMIQUE.
The role of the immune system in anogenital human papillomavirus
Frazer, I. H. (1998). The role of the immune system in anogenital human papillomavirus.
Hpv16 E7 Transgenic Skin Is Not Rejected in E7 Immunized Mice
Frazer, I. H., Dunn, L. A., Fernando, G. J., Tindle, R. W., Leippe, D. M. and Lambert, P. F. (1995). Hpv16 E7 Transgenic Skin Is Not Rejected in E7 Immunized Mice. Keystone Symposia on Molecular & Cellular Biology, Keystone, CO United States, 16-23 January 1995 . NEW YORK: Wiley-Blackwell.
A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer
Frazer, I. H., Lieppe, D., Lambert, P., Griep, A., Dunn, L., Tindle, R. W. and Fernando, G. (1994). A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer. Keystone Symposia on Molecular & Cellular Biology, Taos, New Mexico , 13 - 20 February 1994. NEW YORK: Wiley-Blackwell.
Observation of human papilloma type 6 VLPs in insect cells
Hamilton, R, Goodwin, F, Hayden, M, Kalnins, H, Park, D, Frazer, I and Edwards, S (1994). Observation of human papilloma type 6 VLPs in insect cells. 13th International Congress on Electron Microscopy, Paris France, Jul 17-22, 1994.
Fernando, G. J. P., Tindle, R. W., Frazer, I. H., Stenzel, D. J., Merza, M. S. and Morein, B. (1994). Small Synthetic Peptides as Vaccines - a Model Peptide Iscom Construct From Cancer-Associated Human Papillomavirus. 11th Annual Meeting on Modern Approaches to New Vaccines, Cold Spring Harbor, NY United States, September 1993. PLAINVIEW: COLD SPRING HARBOR LABORATORY PRESS.
Londono, P., Chatfield, S., Tindle, R., Frazer, I. and Dougan, G. (1994). Use of a Double Aro Salmonella Mutant to Stably Express Hbv16 E7 Protein Epitopes Carried by the Hbv Core Antigen. In: Journal of Cellular Biochemistry. Keystone Symposia on Molecular & Cellular Biology, Taos, New Mexico , (232-232). 13 - 20 February 1994.
A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer
Frazer, I. H., Lieppe, D., Lambert, P., Griep, A., Tindle, R. W. and Fernando, G. (1993). A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer. -, -, 1993. BETHESDA: FEDERATION AMER SOC EXP BIOL.
Adjuvants Can Bias to Th1 or Th2 the Immune-Response to Hpv E7 Protein in Mice
Fernando, G. J., Zhou, J., Tindle, R. W. and Frazer, I. H. (1993). Adjuvants Can Bias to Th1 or Th2 the Immune-Response to Hpv E7 Protein in Mice. -, -, 1993. BETHESDA: Wiley-Blackwell.
An Improved Immunoassay for the E7 Protein of Hpv16
Dunn, L. A., Tindle, R. W., Fernando, G. J. and Frazer, I. H. (1993). An Improved Immunoassay for the E7 Protein of Hpv16. -, -, 1993. BETHESDA: Wiley-Blackwell.
Antigen Presentation as a Determinant of the Outcome of Papillomavirus Infection
Frazer, IH (1993). Antigen Presentation as a Determinant of the Outcome of Papillomavirus Infection.
Precursors of Cervical-Cancer - the Male Factor
Oconnor, DT, Frazer, I and Kennedy, L (1993). Precursors of Cervical-Cancer - the Male Factor. 7Th World Congress of Cervical Pathology and Colposcopy, Rome Italy, May , 1990.
Use of Recombinant Hepatitis-B Core Antigen Particles to Deliver Hpv16-E7 Immunogenic Signals
Tindle, R., Londono, P., Herd, K., Frazer, I. and Dougan, G. (1993). Use of Recombinant Hepatitis-B Core Antigen Particles to Deliver Hpv16-E7 Immunogenic Signals. -, -, -. Oxford, United Kingdom: John Wiley & Sons.
A Study of the Longer Term Efficacy of Fenfluramine
Douglas, JG, Gough, J, Preston, PG, Frazer, I, Haslett, C, Chalmers, SR and Munro, JF (1983). A Study of the Longer Term Efficacy of Fenfluramine.
Antibodies to Liver Membrane-Antigens in Chronic Liver-Disease
Frazer, IH, Kronborg, IJ and Mackay, IR (1983). Antibodies to Liver Membrane-Antigens in Chronic Liver-Disease.
Copper, Zinc and Jejuno-Ileal Bypass-Surgery
Ford, MJ, Sircus, W, Frazer, I, Terry, SI, Munro, JF and Suttle, NF (1983). Copper, Zinc and Jejuno-Ileal Bypass-Surgery. International Conf On Blood Use in Cardiac Surgery, Berlin Fed Rep Ger, Dec 08-10, 1989. DR DIETRICH STEINKOPFF VERLAG.
Frazer, IH, Bell, J, Becker, G and Mackay, IR (1983). Identification of Immune Effector-Cells in the Liver of Patients with Chronic Active Hepatitis Using Monoclonal Antisera.
Radioimmunoassay for Antibody to Liver Membrane Antigen Using Isolated Monkey Hepatocytes
Kronborg, IJ, Mackay, IR and Frazer, IH (1982). Radioimmunoassay for Antibody to Liver Membrane Antigen Using Isolated Monkey Hepatocytes.
Zhonghua Yixuezazhi (National Medical Journal of China)
Zhonghua Yixuezazhi (National Medical Journal of China). (2002). 82 (9)
NHMRC Guidelines Review Group, Connelly, Luke B. and Frazer, Ian (2005). Screening to prevent cervical cancer: Guidelines for the management of asymptomatic women with screen detected abnormalities. Canberra, Australia: Commonwealth of Australia.
Subunit papilloma virus vaccine and peptides for use therein
Tindle, Robert, Fernando, Germain and Frazer, Ian (2001). Subunit papilloma virus vaccine and peptides for use therein. US6183745B1.
(2022–2025) Metro South Hospital and Health Service
(2022–2025) Griffith University
(2022–2024) The Hebrew University of Jerusalem
Assessment of predictors of response to checkpoint blockade
(2021–2023) PA Research Foundation
(2021–2023) NHMRC Development Grant
(2021–2023) Metro South Hospital and Health Service
Pathogen promoters of squamous epithelial cancer
(2020–2024) NHMRC Investigator Grants
Saving your skin: physiology of immune regulation in mammalian lymph nodes
(2020–2022) ARC Discovery Projects
(2018–2020) Australian Society for Colposcopy & Cervical Pathology Incorporated
Human HPV Assay Development and Testing
(2018–2019) Admedus Vaccines Pty Ltd
ARC Training Centre for Innovation in Biomedical Imaging Technology
(2017–2024) ARC Industrial Transformation Training Centres
Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
(2017–2019) Cancer Council Queensland
Is there really a viral cause for skin cancer?
(2017–2018) Australasian College of Dermatologists Scientific Research Fund
Memory CD8+ T-cell function in squamous cell carcinoma
(2017–2018) Cancer Council Queensland
Reducing adverse reactions and boosting immune response to HPV vaccination with exercise
(2017) University of Sydney
Rapid functional and taxonomic skin microbe characterisation
(2016–2019) ARC Linkage Projects
Establishing a gnotobiotic germ-free mouse facility
(2016) UQ Major Equipment and Infrastructure
The Australian human microbiota project-microbe isolation facility
(2016) UQ Major Equipment and Infrastructure
Immunological therapies for cancer, chronic infection and autoimmunity
(2015–2019) NHMRC Program Grant
Deciphering novel control mechanisms in the skin
(2015–2017) ARC Discovery Projects
Evaluate ODS MOA in inhibiting DNCB-induced ear swelling in K14-E7.
(2015–2016) UniQuest Pty Ltd
(2015–2016) Queensland University of Technology
(2015–2016) Data Management Med-High-Tech GmbH
Determinants of progression of actinic keratoses to squamous cancer
(2014–2018) NHMRC Project Grant
(2014–2017) Garnett Passe/Rodney Williams Memorial Foundation
(2014–2015) Cancer Council Queensland
The Diamantina Individualised Oncology Care Centre (DIOCC)
(2013–2020) Australian Cancer Research Foundation
Investigating a novel, physical adjuvant for improving immune responses of vaccines
(2013–2016) ARC Linkage Projects
Sterile inflammation as a determinant of adaptive immunity
(2013–2016) ARC Discovery Projects
Optimising immunotherapy for squamous cancer
(2013–2015) Cancer Research Institute (USA)
Optimizing a vaccine for HPV immunotherapy
(2013–2015) NHMRC Development Grant
Infection and immunity in squamous skin cancer
(2013–2014) Bupa Foundation (Australia) Ltd
Queensland Centre of Excellence for Head and Neck Cancer
(2012–2018) Metro South Hospital and Health Service
(2012–2015) University of New South Wales
Hunting for viruses that cause skin cancer
(2012–2013) PA Research Foundation Private Practice Trust Fund Research Support Grants
RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
(2012–2013) Griffith University
Automated electrophoretic bioanalysis
(2012) NHMRC Equipment Grant
Comprehensive cell imaging facility (ARC LIEF Grant administered by QUT)
(2011–2012) ARC LIEF Collaborating/Partner Organisation Contributions
(2011–2012) Cancer Council Queensland
Laser Scanner for Biomolecular Imaging
(2011) NHMRC Equipment Grant
Immunological therapies for cancer, chronic infection and autoimmunity
(2010–2014) NHMRC Program Grant
(2010–2012) ARC Discovery Projects
RNA interference and the Immune System
(2010–2012) NHMRC Project Grant
PET/CT (positron emission tomography - computed tomography)
(2010–2011) Research Donation Generic
PET/CT (positron emission tomography - computed tomography)
(2010–2011) Research Donation Generic
A sustainable program for prevention of Cervical Cancer in Vanuatu
(2010) International Agency for Research on Cancer
(2010) UQ Major Equipment and Infrastructure
PET/CT (positron emission tomography - computed tomography)
(2010) UQ Major Equipment and Infrastructure
Novel Interventions Against HPV-associated Neoplasia
(2009–2014) University of Wisconsin-Madison
International Needle-free Vaccination Alliance (INVax)
(2009–2012) Queensland Government Smart State National and International Research Alliances Program
(2009–2011) NHMRC Urgent Research - H1N1 Influenza 09
Nanopatch immunisation against pandemic influenza: improved immune responses at a reduced dose.
(2009–2011) NHMRC Project Grant
(2009–2011) Ramaciotti Foundation
(2009–2011) NHMRC Project Grant
Multiphoton microscopy of living animals as a tool for immunology and cell biology studies
(2009–2010) ARC Linkage Infrastructure, Equipment and Facilities
(2009–2010) Cancer Council Queensland
(2008–2015) Australian Cancer Research Foundation
(2008–2009) Cancer Council Queensland
RNA interference to boost immune responses against cancer
(2008–2009) Cancer Council Queensland
Studying the function of antigen experienced CD4+GITR+T cells
(2008) PA Research Foundation
Effective Immunotherapy for Chronic Infection and Cancer
(2007–2011) Queensland Government Smart State Premier's Fellowships
(2007–2009) NHMRC Project Grant
Non-viral vectors for targeted delivery of RNAi nucleotides to cervical cancers
(2007–2009) NHMRC Project Grant
Genetic and Genomic Analysis Research Facility
(2007) RL Cooper Medical Research Foundation Limited
Mechanisms of dendritic cell-induced T-cell tolerance
(2006–2008) NHMRC Project Grant
Improving Immunotherapy by Inhibiting IL 10 Mediated Immune Deviation
(2006–2007) NHMRC Development Grant
Molecular mechanisms of regulatory expression of human papillomavirus L1 genes in keratinocytes
(2006–2007) Queensland Cancer Fund
Immunological therapies for cancer and autoimmunity
(2005–2009) NHMRC Program Grant
A phase IB trial of virus like particle immunotherapy for HPV associated infection
(2005–2007) Cancer Research Institute (USA)
(2005–2007) James Cook University
Optimising Immunotherapy in Tumour Antigen Experienced Host
(2005–2006) Queensland Cancer Fund
The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
(2005–2006) Queensland Cancer Fund
Cationic Complexes for Targeted Delivery of Polynucleotide Vaccines to Skin Cells
(2005) University of Queensland Research Development Grants Scheme
(2005) NHMRC Equipment Grant
(2005) NHMRC Equipment Grant
NHMRC_Equipment Grant _HLTH_CICR_Med SCD
(2004–2005) NHMRC Equipment Grant
(2003–2010) Wellcome Trust
Evaluating Therapeutic Interventions to Overcome Tolerance to Tumour Antigen
(2003–2004) Queensland Cancer Fund
Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
(2003–2004) NHMRC Project Grant
(2003–2004) Princess Alexandra Hospital R&D Foundation
Array WoRx-e Microarray-Scanner System
(2003) NHMRC Equipment Grant
Effective immunotherapy for HPV associated cervical cancer precusor lesions
(2002–2004) NHMRC Project Grant
How does tRNA correlate with codon usage to regulate the expression of papillomavirus late genes?
(2002–2003) Queensland Cancer Fund
A skin graft model of immunotherapy for cervical cancer.
(2002) Princess Alexandra Hospital R&D Foundation
Codon usage/tRNA matching: a novel method of gene regulation in plants
(2001–2004) Grains Research & Development Corporation
Evaluation of codon usage/tRNA matching as a novel method of regulation of genes in plants
(2001–2004) Grains Research & Development Corporation
CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
(2001–2003) NHMRC Project Grant
A Phase 1B Trial of Specific Immunotherapy for Recurrent Respiratory Papillomatosis
(2001–2002) NHMRC Project Grant
(2001) Princess Alexandra Hospital R&D Foundation
Endogenous Antigen Presentation By Epithelial Tumours
(2001) Princess Alexandra Hospital R&D Foundation
(2001) University of Queensland Small Grants Scheme
A model for epithelial tumour immunotherapy
(2000) Princess Alexandra Hospital R&D Foundation
(2000) NHMRC Equipment Grant
(2000) Cancer Bequest Fund
(1999–2002) Cancer Research Institute (USA)
Cell mediated immunity in the early control of papillomavirus infection
(1999–2001) NHMRC Project Grant
Determinants of Effective Immunotherapy for Epithelial Tumours
(1999–2001) NHMRC Project Grant
Development and evaluation of hybrid novel mucosal vaccines
(1999–2001) United States National Institutes of Health
How does papillomavirus regulate its late gene expression
(1999–2001) NHMRC Project Grant
The Role of the Human Papillomavirus in Alpha-6-Integrin Activation and Cell Growth
(1999–2001) NHMRC Project Grant
(1999–2000) Queensland Cancer Fund
(1999–2000) Queensland Cancer Fund
CTL avidity and cell number as determinants of E7 tumour regression in vivo
(1999) Cancer Bequest Fund
Cell mediated immunity in the early control of papillomavirus infection
(1999) Mayne Bequest Fund
(1999) Princess Alexandra Hospital R&D Foundation
CTL Acquisition of Avidity and Function is Determined by Cytokine Environment and Antigen
(1998–1999) Princess Alexandra Hospital R&D Foundation
Investigation of the interaction between the alpha 6-integrin and human papillomaviruses
(1998–1999) Queensland Cancer Fund
The Role of B7 Co-stimulatory Molecules in Antigen Presentation by Keratinocytes of the Skin
(1998–1999) Princess Alexandra Hospital R&D Foundation
(1998) Mayne Bequest Fund
(1998) Mayne Bequest Fund
The role of E2F in skin cancer development
(1998) Queensland Cancer Fund
Polyprotein immunogens as a novel approach to viral vaccines
(1997–1999) ARC Collaborative Grant (SPIRT)
T help as a determinant of effector CTL function in immunotherapy
(1997–1999) NHMRC Project Grant
Immune evasion in cervical cancer through block detection of MHC locus genes
(1997) Princess Alexandra Hospital R&D Foundation
Microplate scintillation and luminescence counter (Packard Top Count) and cell harvester
(1997) Ramaciotti Foundation
Polyprotein immunogens as a novel approach to viral vaccines
(1997) Commonwealth Serum Laboratories
Presentation of antigen by kearatinocytes to naive and memory T helper cells
(1997) Mayne Bequest Fund
The role of E2F1 in human skin cancer development
(1997) Princess Alexandra Hospital R&D Foundation
Binding and uptake of papillomavirus particles and epithelial cells
(1996–1998) NHMRC Project Grant
Immune requirements for killing epithelial tumour cells
(1996–1998) Queensland Cancer Fund
(1996–1997) 3M Australia Pty Limited
(1996–1997) Quality Funds Round 3
International papillomavirus workshop
(1996–1997) United States National Institutes of Health
(1996–1997) Viertel Foundation (Sylvia and Charles Viertel)
How do viruses evade the interferon system
(1996) UQ Foundation
Immune evasion in cervical cancer through block deletions of MHC locus genes
(1996) Princess Alexandra Hospital R&D Foundation
The immunobiology of HPV-associated cancers
(1995–1998) United States National Institutes of Health
(1995–1996) ARC Collaborative Grant (SPIRT)
Optimising immunity towards tumours by vaccination
(1995) Cancer Bequest Fund
Promoter elements mediating transcriptional repression during keratinocyte growth arrest
(1995) Mayne Bequest Fund
Testing immunotherapy for cancer using an automated counting system
(1995) Ramaciotti Foundation
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Doctor Philosophy — Principal Advisor
Pathogen Promoters of Squamous Epithelial Cancer
Doctor Philosophy — Principal Advisor
Assessment of predictors of response to checkpoint blockades in cancer patients.
Doctor Philosophy — Associate Advisor
Other advisors:
Effect of hexarelin, a synthetic small peptide, on metabolic balance of obese and diabetic mice
Doctor Philosophy — Associate Advisor
Other advisors:
The role of the skin microbiota in cutaneous squamous cell carcinoma
(2021) Doctor Philosophy — Principal Advisor
Other advisors:
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
(2020) Doctor Philosophy — Principal Advisor
Other advisors:
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
(2018) Doctor Philosophy — Principal Advisor
Other advisors:
(2017) Master Philosophy — Principal Advisor
(2015) Doctor Philosophy — Principal Advisor
(2014) Doctor Philosophy — Principal Advisor
Other advisors:
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
(2013) Doctor Philosophy — Principal Advisor
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
(2010) Doctor Philosophy — Principal Advisor
Other advisors:
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
(2010) Doctor Philosophy — Principal Advisor
Role of dendritic epidermal T cells in skin graft rejection
(2010) Doctor Philosophy — Principal Advisor
Other advisors:
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
Interleukin-1 as a determinant of effector T cell function
(2008) Master Philosophy — Principal Advisor
Studies on mechanisms of skin graft rejection
(2008) Doctor Philosophy — Principal Advisor
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
(2003) Doctor Philosophy — Principal Advisor
Other advisors:
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
(2002) Doctor Philosophy — Principal Advisor
Other advisors:
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
(2022) Doctor Philosophy — Associate Advisor
Other advisors:
The role of CD8+ T cells in the regression of squamous cell carcinoma
(2021) Doctor Philosophy — Associate Advisor
Other advisors:
Uncovering novel regulators of CD8+ T-cell function in the skin
(2017) Doctor Philosophy — Associate Advisor
Other advisors:
(2016) Doctor Philosophy — Associate Advisor
Other advisors:
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
Contributions of Wnt signalling to immune responses during acute bacterial infection
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
(2011) Doctor Philosophy — Associate Advisor
Other advisors:
(2008) Doctor Philosophy — Associate Advisor
Other advisors:
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
() Doctor Philosophy — Associate Advisor
Other advisors:
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
(2007) Doctor Philosophy — Associate Advisor
Regulation of squamous differentiation by the E2F family transcription factors
(2005) Doctor Philosophy — Associate Advisor
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
(2003) Doctor Philosophy — Associate Advisor
Other advisors:
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
(2003) Doctor Philosophy — Associate Advisor
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
(2003) Doctor Philosophy — Associate Advisor