The University of Queensland

Codon modifications redirect expression of HPV16 E7 oncogene and human oncosuppressor genes (p53 & Rb) in keratinocytes (2008–2009)

Abstract:

Human papillomavirus (HPV) infection causes formation of different epithelial cancers including cervical cancer, which is a major cause of cancer death in women worldwide. The cancers are due to the interaction of the viral oncogene with oncosuppressor genes in HPV-infected cells. Here, we will study a novel mechanism that regulates expression of viral oncogene and oncosuppressor genes in host cells to develope an effective gene therapy for HPV-induced cancers.

Grant type:

Cancer Council Queensland

Researchers:

• 

  Dr Kong-Nan Zhao

  Research Fellow
  

  Australian Institute for Bioengineering and Nanotechnology

• 

  Professor Ian Frazer

  Emeritus Professor
  

  Faculty of Medicine

Funded by:

Cancer Council Queensland