The University of Queensland

Assaying for radioresistant DNA synthesis, the hallmark feature of the intra-S-phase checkpoint using a DNA fiber technique

Kijas, Amanda W. and Lavin, Martin F. (2017). Assaying for radioresistant DNA synthesis, the hallmark feature of the intra-S-phase checkpoint using a DNA fiber technique. ATM kinase: methods and protocols. (pp. 13-23) edited by Sergei V. Kozlov. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-6955-5_2

ATM mediated signaling defends the integrity of the genome

Lavin, Martin F., Gatei, Magtouf, Chen, Philip, Kijas, Amanda and Kozlov, Sergei (2010). ATM mediated signaling defends the integrity of the genome. Handbook of Cell Signaling. (pp. 2171-2183) edited by Ralph A. Bradshaw and Edward A. Dennis. Amsterdam, The Netherlands: Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00263-1

Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation

Wang, Zhao, Lauko, Jan, Kijas, Amanda W., Gilbert, Elliot P., Turunen, Petri, Yegappan, Ramanathan, Zou, Dongxiu, Mata, Jitendra and Rowan, Alan E. (2023). Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation. Nature Communications, 14 (1) 1029, 1-16. doi: 10.1038/s41467-023-36437-9

Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding

Yegappan, Ramanathan, Lauko, Jan, Wang, Zhao, Lavin, Martin F., Kijas, Amanda W. and Rowan, Alan E. (2022). Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding. Advanced Healthcare Materials, 11 (15) 2200574, 2200574. doi: 10.1002/adhm.202200574

The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States

Choi, Jung Un Ally, Kijas, Amanda W., Lauko, Jan and Rowan, Alan E. (2022). The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States. Frontiers in Cell and Developmental Biology, 9 770143, 770143. doi: 10.3389/fcell.2021.770143

Heterodyne Brillouin microscopy for biomechanical imaging

Taylor, Michael A., Kijas, Amanda W., Wang, Zhao, Lauko, Jan and Rowan, Alan E. (2021). Heterodyne Brillouin microscopy for biomechanical imaging. Biomedical Optics Express, 12 (10) 6259, 6259-6268. doi: 10.1364/boe.435869

Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses

Ovchinnikov, Dmitry A., Withey, Sarah L., Leeson, Hannah C., Lei, U. Wang, Sundarrajan, Ashmitha, Junday, Keerat, Pewarchuk, Michelle, Yeo, Abrey J., Kijas, Amanda W., Lavin, Martin F. and Wolvetang, Ernst J. (2020). Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses. Human Molecular Genetics, 29 (6), 990-1001. doi: 10.1093/hmg/ddaa023

Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

Lim, Yi Chieh, Ensbey, Kathleen S., Offenhäuser, Carolin, D'souza, Rochelle C. J., Cullen, Jason K., Stringer, Brett W., Quek, Hazel, Bruce, Zara C., Kijas, Amanda, Cianfanelli, Valentina, Mahboubi, Bijan, Smith, Fiona, Jeffree, Rosalind L., Wiesmüeller, Lisa, Wiegmans, Adrian P., Bain, Amanda, Lombard, Fanny J., Roberts, Tara L., Khanna, Kum Kum, Lavin, Martin F., Kim, Baek, Hamerlik, Petra, Johns, Terrance G., Coster, Mark J., Boyd, Andrew W. and Day, Bryan W. (2020). Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore. Neuro-Oncology, 22 (2), 216-228. doi: 10.1093/neuonc/noz159

Therapeutic targets and investigated treatments for Ataxia-Telangiectasia

Lavin, Martin F., Yeo, Abrey J., Kijas, Amanda W., Wolvetang, Ernst, Sly, Peter D., Wainwright, Claire and Sinclair, Kate (2016). Therapeutic targets and investigated treatments for Ataxia-Telangiectasia. Expert Opinion on Orphan Drugs, 4 (12), 1263-1276. doi: 10.1080/21678707.2016.1254618

ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor

Lavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015). ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 (4) A31, 2877-2902. doi: 10.3390/biom5042877

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

Gatei, Magtouf, Kijas, Amanda W., Biard, Denis, Dork, Thilo and Lavin, Martin F. (2014). RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. Human Molecular Genetics, 23 (16) ddu141, 4232-4248. doi: 10.1093/hmg/ddu141

A patient-derived olfactory stem cell disease model for ataxia-telangiectasia

Stewart, Romal, Kozlov, Sergei, Matigian, Nicholas, Wali, Gautam, Gatei, Magtouf, Sutharsan, Ratneswary, Bellette, Bernadette, Kijas, Amanda Wraith, Cochrane, Julie, Coulthard, Mark, Perry, Chris, Sinclair, Kate, Mackay-Sim, Alan and Lavin, Martin F. (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22 (12), 2495-2509. doi: 10.1093/hmg/ddt101

A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells

Lim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Harding, Angus, Kozlov, Sergei, Kijas, Amanda W., Ensbey, Kathleen S., Walker, David G. and Lavin, Martin F. (2012). A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Molecular Cancer Therapeutics, 11 (9), 1863-1872. doi: 10.1158/1535-7163.MCT-11-1044

ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control

Gatei, Magtouf, Jakob, Burkhard, Chen, Philip, Kijas, Amanda W., Becherel, Olivier J., Gueven, Nuri, Birrell, Geoff, Lee, Ji-Hoon, Paull, Tanya T., Lerenthal, Yaniv, Fazry, Shazrul, Taucher-Scholtz, Gisela, Kalb, Reinhard, Schindler, Detlev, Waltes, Regina, Doerk, Thilo and Lavin, Martin F. (2011). ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. Journal of Biological Chemistry, 286 (36), 31542-31556. doi: 10.1074/jbc.M111.258152

Autophosphorylation and ATM activation: Additional sites add to the complexity

Kozlov, Sergei V., Graham, Mark E., Jakob, Burkhard, Tobias, Frank, Kijas, Amanda W., Tanuji, Marcel, Chen, Philip, Robinson, Phillip J., Taucher-Scholz, Gisela, Suzuki, Keiji, So, Sairai, Chen, David and Lavin, Martin F. (2011). Autophosphorylation and ATM activation: Additional sites add to the complexity. The Journal of Biological Chemistry, 286 (11), 9107-9119. doi: 10.1074/jbc.M110.204065

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

Becherel, Olivier J., Jakob, Burkhard, Cherry, Amy L., Gueven, Nuri, Fusser, Markus, Kijas, Amanda W., Peng, Cheng, Katyal, Sachin, McKinnon, Peter J., Chen, Junjie, Epe, Bernd, Smerdon, Stephen J., Taucher-Scholz, Gisela and Lavin, Martin F. (2010). CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Research, 38 (5) gkp1149, 1489-1503. doi: 10.1093/nar/gkp1149

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

Waltes, R, Kalb, R, Gatei, M, Kijas, AW, Stumm, M, Sobeck, A, Wieland, B, Varon, R, Lerenthal Y, Lavin, Martin F., Schindler, D and Dörk, T (2009). Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.. American Journal of Human Genetics, 84 (5), 605-616. doi: 10.1016/j.ajhg.2009.04.010

A subgroup of spinocerebellar ataxias defective in DNA damage responses

Gueven, N., Chen, P., Nakamura, J., Becherel, O.J., Kijas, A.W., Grattan-Smith, P. and Lavin, M.F. (2007). A subgroup of spinocerebellar ataxias defective in DNA damage responses. Neuroscience, 145 (4), 1418-1425. doi: 10.1016/j.neuroscience.2006.12.010

Aprataxin forms a discrete branch in the HIT (Histidine Triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities

Kijas, Amanda W., Harris, Janelle L., Harris, Jonathan M. and Lavin, Martin F. (2006). Aprataxin forms a discrete branch in the HIT (Histidine Triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. Journal of Biological Chemistry, 281 (20), 13939-13948. doi: 10.1074/jbc.M507946200

msh2 separation of function mutations confer defects in the initiation steps of mismatch repair

Kijas, Amanda Wraith, Studamire, Barbara and Alani, Eric (2003). msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. Journal of Molecular Biology, 331 (1), 123-138. doi: 10.1016/S0022-2836(03)00694-6

Crystal structure and biochemical analysis of the MutS dot ADP dot beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair

Alani, Eric, Lee, Jae Young, Schofield, Mark J., Kijas, Amanda W., Hsieh, Peggy and Yang, Wei (2003). Crystal structure and biochemical analysis of the MutS dot ADP dot beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair. Journal of Biological Chemistry, 278 (18), 16088-16094. doi: 10.1074/jbc.M213193200

Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair

Argueso, Juan Lucas, Kijas, Amanda Wraith, Sarin, Sumeet, Heck, Julie, Waase, Marc and Alani, Eric (2003). Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair. Molecular and Cellular Biology, 23 (3), 873-886. doi: 10.1128/MCB.23.3.873-886.2003

Origins of the many NPY-family receptors in mammals

Larhammar, Dan, Wraith, Amanda, Berglund, Magnus M., Holmberg, Sara K. S. and Lundell, Ingrid (2001). Origins of the many NPY-family receptors in mammals. Peptides, 22 (3), 295-307. doi: 10.1016/S0196-9781(01)00331-X

Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster

Söderberg, Charlotte, Wraith, Amanda, Ringvall, Maria, Yan, Yi-Lin, Postlethwait, John H., Brodin, Lennart and Larhammar, Dan (2000). Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. Journal of Neurochemistry, 75 (3), 908-918. doi: 10.1046/j.1471-4159.2000.0750908.x

Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig

Wraith, Amanda, Törnsten, Anna, Chardon, Patrick, Harbitz, Ingrid, Chowdhary, Bhanu P., Andersson, Leif, Lundin, Lars-Gustav and Larhammar, Dan (2000). Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome Research, 10 (3), 302-310. doi: 10.1101/gr.10.3.302

Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors

Sharma, Parul, Arvidsson, Ann-Kristin, Wraith, Amanda, Beck-Sickinger, Annette G., Jönsson-Rylander, Ann-Cathrine and Larhammar, Dan (1999). Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors. General and Comparative Endocrinology, 115 (3), 422-428. doi: 10.1006/gcen.1999.7332

Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor

Starbäck, P., Lundell, I., Fredriksson, R., Berglund, M. M., Yan, Y. L., Wraith, A., Söderberg, C., Postlethwait, J. H. and Larhammar, D. (1999). Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Molecular Brain Research, 70 (2), 242-252. doi: 10.1016/S0169-328X(99)00152-7

Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor

Arvidsson, Ann-Kristin, Wraith, Amanda, Jönsson-Rylander, Ann-Cathrine and Larhammar, Dan (1998). Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Regulatory Peptides, 75-76, 39-43. doi: 10.1016/S0167-0115(98)00051-2

Neutrophils induce damage to respiratory epithelial cells infected with respiratory syncytial virus.

Wang, S. Z., Xu, H., Wraith, A., Bowden, J. J., Alpers, J. H. and Forsyth, K. D. (1998). Neutrophils induce damage to respiratory epithelial cells infected with respiratory syncytial virus.. European Respiratory Journal, 12 (3), 612-618. doi: 10.1183/09031936.98.12030612

FISH mapping of the porcine NPY5 gene to chromosome 8p11

Törnsten, A., Wraith, A., Larhammar, D. and Chowdhary, B. P. (1998). FISH mapping of the porcine NPY5 gene to chromosome 8p11. Mammalian Genome, 9 (3), 262-263. doi: 10.1007/s003359900742

Response of glioma initiating cells to ionising radiation

Lim, Y. C., Roberts, T., Day, B., Harding, A., Ensbey, K., Kozlov, S., Kijas, A., Walker, D. and Lavin, M. (2012). Response of glioma initiating cells to ionising radiation. Targeting Cancer from Diagnosis to Cure & 5th Annual COGNO Annual Scientific Meeting, Brisbane, QLD, Australia, 8-10 August 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2012.01586_2.x