Dr Avril Robertson

Senior Research Officer

Institute for Molecular Bioscience

Affiliated Senior Research Officer

School of Chemistry and Molecular Biosciences
Faculty of Science

Overview

Qualifications

  • Doctor of Philosophy, University of St Andrews
  • Master in Chemistry with First Class Honours, University of St Andrews

Publications

  • Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017) Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 10: 1-11. doi:10.1038/s41564-017-0015-4

  • O'Neill, Luke , Coll, Rebecca , Cooper, Matt , Robertson, Avril , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Sulfonylureas and related compounds and use of the same. WO2017140778.

  • Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017) Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 17: 1449-1457. doi:10.1002/cmdc.201700270

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

  • Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017) Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 10: 1-11. doi:10.1038/s41564-017-0015-4

  • Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017) Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 17: 1449-1457. doi:10.1002/cmdc.201700270

  • Kim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017) Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 3: 283-297. doi:10.1164/rccm.201609-1830OC

  • Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017) Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 28: 11829-11839. doi:10.1074/jbc.M117.787994

  • Pavillard, Luis E., Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A. B., Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A., Quiles, José L., Bullón, Pedro, Ruiz-Cabello, Jesús and Cordero, Mario D. (2017) NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, . doi:10.18632/oncotarget.20763

  • Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A. B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O'Neill, Luke A., Eltzschig, Holger K., Masters, Seth L. and McNamee, Eoin N. (2017) Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. Journal of Experimental Medicine, 214 6: 1737-1752. doi:10.1084/jem.20160462

  • Dinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, De Silva, T. Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A. B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles and Sobey, Christopher G. (2017) Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging, 9 6: 1595-1606. doi:10.18632/aging.101255

  • Mridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017) NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 5: 1037-1046. doi:10.1016/j.jhep.2017.01.022

  • Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidliar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andres, Vicente, Hirschi, Karen K., Martin, Kathleen A. and Walsh, Kenneth (2017) Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science, 355 6327: 842-847. doi:10.1126/science.aag1381

  • Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017) GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 7: 3049-3059. doi:10.1074/jbc.M116.767533

  • Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017) Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 3: 346-359. doi:10.1016/j.chembiol.2017.01.003

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 . doi:10.7554/eLife.21221

  • Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017) Inflammasomes in the lung. Molecular Immunology, 86 44-55. doi:10.1016/j.molimm.2017.01.014

  • Song, Erfei, Jahng, James W. S., Chong, Lisa P., Sung, Hye K., Han, Meng, Luo, Cuiting, Wu, Donghai, Boo, Stellar, Hinz, Boris, Cooper, Matthew A., Robertson, Avril A. B., Berger, Thorsten, Mak, Tak W., George, Isaac, Schulze, P. Christian, Wang, Yu, Xu, Aimin and Sweeney, Gary (2017) Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research, 9 6: 2723-+.

  • Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016) The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 25: 2960-2975. doi:10.1182/blood-2016-07-730556

  • Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61 306-316. doi:10.1016/j.bbi.2016.12.014

  • Pinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D. and Mansell, Ashley (2017) PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome. The Journal of Biological Chemistry, 292 3: 826-836. doi:10.1074/jbc.M116.756379

  • Groß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016) K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 4: 761-773. doi:10.1016/j.immuni.2016.08.010

  • Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong-Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A. and Robertson, Avril A. B. (2016) Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950. ACS Medicinal Chemistry Letters, 7 12: 1034-1038. doi:10.1021/acsmedchemlett.6b00198

  • Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016) Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 9: 651-663. doi:10.1021/acsinfecdis.6b00121

  • LaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M. and Nizet, Victor (2016) IL-1beta is an innate immune sensor of microbial proteolysis. Science Immunology, 1 2: . doi:10.1126/sciimmunol.aah3539

  • van Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard and Hoefer, Imo E. (2016) The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart Journal, 1-10. doi:10.1093/eurheartj/ehw247

  • Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016) T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 6292: 1424+-U95. doi:10.1126/science.aad1210

  • Tate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J. and Mansell, Ashley (2016) Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Scientific Reports, 6 . doi:10.1038/srep27912

  • Tucey, Timothy M., Verma-Guar, Jiyoti, Nguyen, Julie, Hewitt, Victoria L., Lo, Tricia L., Shingu-Vazquez, Miguel, Robertson, Avril A. B., Hill, James R., Pettolino, Filomena A., Beddoe, Travis, Cooper, Matthew A., Naderer, Thomas and Traven, Ana (2016) The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signals. mSphere, 1 3: 1-18. doi:10.1128/mSphere.00074-16

  • Gaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Rapino, Francesca, Robertson, Avril A. B., Cooper, Matthew A., Graf, Thomas and Hornung, Veit (2016) Human monocytes engage an alternative inflammasome pathway. Immunity, 44 4: 833-846. doi:10.1016/j.immuni.2016.01.012

  • Schaale, K., Peters, K. M., Murthy, A. M., Fritzsche, A. K., Phan, M.-D., Totsika, M., Robertson, A. A. B., Nichols, K. B., Cooper, M. A., Stacey, K. J., Ulett, G. C., Schroder, K., Schembri, M. A. and Sweet, M. J. (2016) Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.. Mucosal Immunology, 9 1: 124-136. doi:10.1038/mi.2015.44

  • Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015) NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 10: 2918-2926. doi:10.1002/eji.201545655

  • Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. and Drummond, G. R. (2015) The inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induce hypertension in mice. British Journal of Pharmacology, 173 4: 752-765. doi:10.1111/bph.13230

  • Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 3: 248-257. doi:10.1038/nm.3806

  • Butler, Mark S., Robertson, Avril A. B. and Cooper, Matthew A. (2014) Natural product and natural product derived drugs in clinical trials. Natural Product Reports, 31 11: 1612-1661. doi:10.1039/c4np00064a

  • Greenhill, Claire J., Jones, Gareth W., Nowell, Mari A., Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul N., Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela, Taylor, Philip R., O'Neill, Luke A., Humphreys, Ian R., Williams, Anwen S. and Jones, Simon A. (2014) Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy, 16 4: . doi:10.1186/s13075-014-0419-y

  • Mamidyala, Sreeman K., Ramu, Soumya, Huang, Johnny X., Robertson, Avril A. B. and Cooper, Matthew A. (2013) Efficient synthesis of anacardic acid analogues and their antibacterial activities. Bioorganic & Medicinal Chemistry Letters, 23 6: 1667-1670. doi:10.1016/j.bmcl.2013.01.074

  • Robertson, Avril and Botting, Nigel P. (2006) The synthesis of glucosinolates deuterium labelled in the glucose fragment. Journal of Labelled Compounds and Radiopharmaceuticals, 49 13: 1201-1211. doi:10.1002/jlcr.1141

  • Bashford, Katherine E., Burton, Matthew B., Cameron, Stuart, Cooper, Anthony L., Hogg, Rebecca D., Kane, Peter D., MacManus, David A., Matrunola, Christopher A., Moody, Christopher J., Robertson, Avril A. B. and Warne, Mark R. (2003) The Bohlmann–Rahtz route to functionalised pyridine scaffolds and their use in library synthesis. Tetrahedron Letters, 44 8: 1627-1629. doi:10.1016/S0040-4039(03)00034-0

  • Kiddle, Guy, Bennett, Richard N., Botting, Nigel P., Davidson, Nicola E., Robertson, Avril A. B. and Wallsgrove, Roger M. (2001) High-performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV, NMR and chemical ionisation-MS methods. Phytochemical Analysis, 12 4: 226-242. doi:10.1002/pca.589

  • Griffiths, D. W., Bain, H., Deighton, N., Botting, N. P. and Avril Robertson (2000) Evaluation of liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry for the identification and quantification of desulphoglucosinolates. Phytochemical Analysis, 11 4: 216-225. doi:10.1002/1099-1565(200007/08)11:4<216::AID-PCA526>3.3.CO;2-U

  • Robertson, Avril and Botting, Nigel P. (1999) Synthesis of deuterium labelled desulfoglucosinolates as internal standards for LC-MS analysis. Tetrahedron, 55 46: 13269-13284. doi:10.1016/S0040-4020(99)00817-0

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision