Dr Susannah Tye

Senior Research Fellow

Queensland Brain Institute
s.tye@uq.edu.au
+61 7 344 32493

Overview

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Research Interests

  • Deep Brain Stimulation
  • Neuromodulation
  • Depression
  • Bipolar Disorder
  • Stress Disorders
  • Parkinson's Disease
  • Biomarkers
  • Refractory Psychiatric Illness

Research Impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Qualifications

  • Doctor of Philosophy, Macquarie University

Publications

  • Ahmed, T. Ahmed, Frye, Mark A., Rush, A. John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima and Dunlop, Boadie W. (2018) Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders, 238 1-7. doi:10.1016/j.jad.2018.05.005

  • Nguyen, Thanh Thanh L., Chan, Lily C., Borreginne, Kristin, Kale, Rajas P., Hu, Chunling and Tye, Susannah J. (2018) A review of brain insulin signaling in mood disorders: from biomarker to clinical target. Neuroscience & Biobehavioral Reviews, 92 7-15. doi:10.1016/j.neubiorev.2018.05.014

  • Cullen, Kathryn R., Amatya, Palistha, Roback, Mark G., Albott, Christina Sophia, Westlund Schreiner, Melinda, Ren, Yanan, Eberly, Lynn E., Carstedt, Patricia, Samikoglu, Ali, Gunlicks-Stoessel, Meredith, Reigstad, Kristina, Horek, Nathan, Tye, Susannah, Lim, Kelvin O. and Klimes-Dougan, Bonnie (2018) Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study. Journal of Child and Adolescent Psychopharmacology, 28 7: 437-444. doi:10.1089/cap.2018.0030

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Kim, Yesul, Wininger, Katheryn M. and Tye, Susannah J. (2016). Deep brain stimulation for treatment-resistant depression. In Deep Brain Stimulation: Indications and Applications (pp. 197-214) : Pan Stanford Publishing Pte. Ltd.. doi:10.1201/9781315364759

Journal Article

Conference Publication

  • Adams, Scott, Kouzani, Abbas Z., Bennet, Kevin and Tye, Susannah J. (2017). Towards in-vivo ATP sensing. In: 2016 IEEE Region 10 Conference (TENCON). , , (2457-2460). . doi:10.1109/TENCON.2016.7848474

  • Kale, Rajas P., Kouzani, Abbas Z., Berk, Julian, Walder, Ken, Berk, Michael and Tye, Susannah J. (2016). Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation. In: , , (1814-1817). . doi:10.1109/EMBC.2016.7591071

  • Parastarfeizabadi, Mahboubeh, Kouzani, Abbas Z., Gibson, Ian and Tye, Susannah J. (2016). A miniature closed-loop deep brain stimulation device. In: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, (1786-1789). August 16, 2016-August 20, 2016. doi:10.1109/embc.2016.7591064

  • Edward, Epsy S., Kouzani, Abbas Z., Kale, Rajas P. and Tye, Susannah J. (2016). Portable closed-loop optogenetic stimulation device. In: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, (5250-5253). August 16, 2016-August 20, 2016. doi:10.1109/embc.2016.7591911

  • Edward, Epsy S., Kouzani, Abbas Z., Berk, Julian and Tye, Susannah J. (2016). A miniature neural recording device. In: 2016 IEEE International Conference on Industrial Technology (ICIT). IEEE International Conference on Industrial Technology, ICIT 2016, Taipei, , (1012-1015). March 14, 2016-March 17, 2016. doi:10.1109/icit.2016.7474892

  • Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. In: Neural Information Processing - 22nd International Conference, ICONIP 2015, Proceedings. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, , (261-272). November 9, 2015-November 12, 2015. doi:10.1007/978-3-319-26555-1_30

  • Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A. and Berk, Michael (2013). Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device. In: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, , , (3078-3081). July 3, 2013-July 7, 2013. doi:10.1109/EMBC.2013.6610191

  • Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. In: 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, , , (851-854). August 28, 2012-September 1, 2012. doi:10.1109/EMBC.2012.6346065

  • Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2012). Multi-layer implantable antenna for closed loop deep brain stimulation system. In: 2012 International Symposium on Communications and Information Technologies, ISCIT 2012. 2012 International Symposium on Communications and Information Technologies, ISCIT 2012, , , (643-648). October 2, 2012-October 5, 2012. doi:10.1109/ISCIT.2012.6380979

  • Hosain, Md. Kamal, Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2012). Design of a miniature UHF PIFA for DBS implants. In: 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings. 6th International Conference on Complex Medical Engineering, CME 2012, , , (485-489). July 1, 2012-July 4, 2012. doi:10.1109/ICCME.2012.6275746

  • Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2011). A head mountable deep brain stimulation device for laboratory animals. In: Advances in Computer, Communication, Control and Automation. 2011 International Conference on Computer, Communication, Control and Automation, 3CA 2011, , , (275-280). November 19, 2011-November 20, 2011. doi:10.1007/978-3-642-25541-0_36

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors: