Associate Professor Trent Woodruff

NHMRC Career Development Fellow

School of Biomedical Sciences
Faculty of Medicine
t.woodruff@uq.edu.au
+61 7 336 52924

Overview

Dr Woodruff is an NHMRC R.D. Wright Fellow (CDF 2) and Associate Professor of Pharmacology who leads a research team aiming to find new theraeuptic treatments for neurodegenerative disease. Current therapies for these diseases are vastly inadequate, and so new research is needed to identify novel targets to slow or halt their progression. Dr Woodruff’s specific research revolves around the innate immune system in the brain, and the role of neuroinflammation in propogating disease. A key focus of his current work is testing new drugs developed at the University of Queensland in models of Parkinson's disease, motor neuron disease (MND; amyotrophic lateral sclerosis) and Huntington’s disease, as well as maintaining an active interest in acute inflammatory disorders. Using a series of potent and orally active complement C5a and NLRP3 inflammasome inhibitors developed at UQ, Dr Woodruff's team has shown the therapeutic potential of targeting innate immune-mediated neuroinflammation to reduce neuronal cell death in animal models of these neurodegenerative diseases. In 2010, Dr Woodruff started his own group and independent laboratory in the School of Biomedical Sciences, UQ. His team has recently shown that in addition to its roles in neurodegeneration, innate immune factors also play essential roles in stem and neuronal cell development during embryogenesis, revealing the widespread physiological and pathological roles of this evolutionarily ancient immune system.

Research Interests

  • Neurodegenerative disease
    Studying new treatments to halt disease progression
  • Parkinson's disease
    Studying new treatments to halt disease progression
  • Motor neuron disease
    Studying new treatments to halt disease progression

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Honours), The University of Queensland

Publications

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Supervision

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Available Projects

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Publications

Featured Publications

Book Chapter

  • Gordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. In Veerle Baekelandt and Evy Lobbestael (Ed.), Disease-modifying targets in neurodegenerative disorders (pp. 43-64) Boston, MA, United States: Academic Press (Elsevier Press).

  • Lee, John D., Lee, Jia Y., Taylor, Stephen M., Noakes, Peter G. and Woodruff, Trent M. (2012). Innate immunity in ALS. In Martin H. Maurer (Ed.), Amyotrophic lateral sclerosis (pp. 393-412) Croatia: InTech - Open Access Publisher.

  • Proctor, Lavinia M., Woodruff, Trent M., Sharma, Prakirti, Shiels, Ian A., Taylor, Stephen M. and Lambris, John D. (2006). Transdermal Pharmacology of Small Molecule Cyclic C5a Antagonists. In John D. Lambris (Ed.), Current Topics in Complement (pp. 329-345) New York: Springer. doi:10.1007/0-387-34134-X_22

Journal Article

Conference Publication

  • Magalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). GUT MICROBIOME CHANGES INDUCED BY EXPERIMENTAL TRICHURIS MURIS INFECTION ARE ASSOCIATED WITH DECREASED COGNITIVE FUNCTION IN MICE. In: 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta Ga, (585-585). Nov 13-16, 2016.

  • Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. In: 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, (36-43). Sep 08-12, 2017. doi:10.1016/j.molimm.2017.05.015

  • Li, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1209-1209). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.186

  • Freeley, Simon, Le Friec, Gaelle, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Pete and Kemper, Claudia (2016). Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1178-1178). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.120

  • West, Erin E., Arbore, Giuseppina, Robertson, Avril A. B., Klos, Andreas, Woodruff, Trent M., O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Joerg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. In: Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, United States, (). 13-17 May 2016.

  • Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1190-1190). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.146

  • Kumar, V, Woodruff, T., Ting, M., Boyd, A., Coulthard, M., Souza-Fonseca-Guimaraes, F. and Smyth, M. (2016). EphA2KO mice survive longer in a mouse model of sepsis. In: International Congress of Immunology (ICI), Melbourne, Australia, (406-406). 21-26 August 2016. doi:10.1002/eji.201670200

  • Biggins, P. J. C., Brennan, F. H., Taylor, S. M., Woodruff, T. M. and Ruitenberg, M. J. (2016). Investigating the role of complement component C5a receptor 2 (C5aR2/C5L2) in spinal cord injury. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1149-1149). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.058

  • Li, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. In: International Congress of Immunology (ICI), Melbourne, Australia, (365-365). 21-26 August 2016. doi:10.1002/eji.201670200

  • Christiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Mathisen, Monica Dammen, Fure, Hilde, Stenvik, Jorgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2016). The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole blood. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1220-1220). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.212

  • Tan, S. M., Nguyen, T. V., Woodruff, T. M. and Coughlan, M. T. (2015). Investigating the role of C5a-CD88 signalling axis in diabetic nephropathy. In: 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, (42-42). 7-9 September, 2015. doi:10.1111/nep.12543

  • Mantovani, S., Gordon, R., Ngo, S., Pfluger, C., O'Sullivan, J., Noakes, P., Henderson, R., McCombe, P. and Woodruff, T. (2015). Peripheral immune complement activation in neurodegenerative disease. In: 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (124-124). 23-27 August 2015. doi:10.1111/jnc.13188

  • Reiner, O., Gorelik, A., Sapir, T., Bialas, A. R., Stevens, B., Woodruff, T. M. and Haffner-Krausz, R. (2015). Unexpected activities of the complement pathway in migrating neurons. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (16-17). 23-27 August 2015. doi:10.1111/jnc.13185

  • Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. In: Abstracts from The 11th Symposium of the International Neurotrauma Society. 11th Symposium of the International-Neurotrauma-Society, Budapest, Hungary, (A26-A26). 19-23 March 2014.

  • Woodruff, Trent M. (2014). C3a and C5a homeostasis in health and disease. In: Abstracts of the XXV International Complement Workshop. 25th International Complement Workshop, Rio de Janeiro Brazil, (247-248). 14-18 September 2014.

  • Croker, Daniel E., Halai, Reena, Kaeslin, Geraldine, Morikis, Dimitrios, Woodruff, Trent, Floudas, Christodoulos A., Monk, Peter N. and Cooper, Matthew A. (2014). Discovery of novel selective C5a2 ligands that can modulate IL-6 releAse from macrophages. In: 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, (35-35). Oct 26-29, 2014. doi:10.1016/j.cyto.2014.07.039

  • Mantovani, S., Li, R., Gordon, R., Kumar, V., Taylor, S. and Woodruff, T. M. (2013). Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease. In: World Congress on Huntington’s disease, Rio de Janeiro, Brazil, (345-345). 15-18 September 2013.

  • Jain, Umang, Woodruff, Trent and Stadnyk, Andrew (2012). Antagonizing C5aR reduces T Cell- IL-10-dependent colitis in pre-clinical models. In: 2012 Advances in Inflammatory Bowel Diseases Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, Fl, United States, (S110-S110). 13-15 December 2012. doi:10.1002/ibd.23058

  • Monkl, Peter N., Bellows-Peterson, Meghan L., Smadbeck, James, Floudas, Christodoulos A., Kieslich, Christopher A., Morikis, Dimitrios and Woodruff, Trent M. (2012). De novo protein design of agonists and antagonists of C5a receptors. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1162-1163). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.097

  • Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. In: Proceedings of the 11th International Congress of Neuroimmunology (ISNI). 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, (89-90). 4-8 November 2012.

  • Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1169-1169). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.116

  • Woodruff, Trent M., Wu, Mike C. L., Brennan, Faith H., Wetsel, Rick A., Ruitenberg, Marc J. and Taylor, Stephen M. (2012). The C3a receptor mediates protection from intestinal ischemia reperfusion injuries by impairing neutrophil mobilization. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1209-1209). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.229

  • Pavlovski, D., Thundyil, J., Taylor, S. M., Arumugam, T., V and Woodruff, T. M. (2012). The complement receptors CD88, C5L2 and C3AR mediate inflammatory injury following transient cerebral ischemia. In: Abstracts of Stroke 2012 Conference - A combined event of the Stroke Society of Australasia 2012 Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference. Stroke 2012 Conference - A combined event of the Stroke Society of Australasia 2012 Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference, Sydney NSW Australia, (13-13). 29-31 August 2012.

  • Costantini, K. J., Coulthard, L. G. J., Lor, Mary, Woodruff, T. M., Callaway, L. K., Finnell, R. H. and Taylor, S. M. (2010). C5aR protects against folate-deficiency induced neural tube defects in mice. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2254-2254). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.169

  • Coulthard, L. G. J., Costantini, K. J., Lor, Mary, Simmons, D., Taylor, S. M. and Woodruff, T. M. (2010). Complement expression in mice throughout neural tube closure. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2251-2251). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.163

  • Woodruff, T. M., Lee, J. D., Taylor, S. M. and Noakes, P. G. (2010). Dysregulation of the complement system in neurodegenerative disease. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2270-2270). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.215

  • Wu, M. C. L., Moore, T. A., Manthey, H. D., Taylor, S. M. and Woodruff, T. M. (2010). The role of complement anaphylatoxin receptors in mesenteric ischemia/reperfusion-induced injury. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2270-2270). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.216

  • Costantini, K. J., Coulthard, L. G., Woodruff, T. M., Taylor, S. M. and Callaway, L. K. (2010). The role of complement-mediated inflammation in miscarriage and preterm birth. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2272-2273). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.222

  • Woodruff, Trent, Denny, Kerina, Crane, James, Atkin, Julie, Taylor, Steve and Noakes, Peter (2008). Blockade of C5a receptors reduces astroglial inflammation in a rat SOD1G93A model of amyotrophic lateral sclerosis. In: Robert Rieben, Molecular Immunology.. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4163-4182). 28 September-02 October 2008. doi:10.1016/j.molimm.2008.08.202

  • Beck, K. D., Nguyen, H. X., Woodruff, T. M. and Anderson, A. J. (2008). Chronic complement-mediated inflammation promotes recovery after spinal cord injury. In: Abstracts of the 39th Annual Meeting of the American Society for Neurochemistry. American Society for Neurochemistry 39th Annual Meeting, San Antonio, United States, (105-105). 1-5 March 2008. doi:10.1111/j.1471-4159.2008.05160.x

  • Moore, Tyson, Woodruff, Trent, Manthey, Helga, Monk, Peter, Taylor, Stephen and Shiels, Ian (2008). Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. In: Robert Rieben, ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September-2 October 2008. doi:10.1016/j.molimm.2008.08.165

  • Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. In: ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4151-4151). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.167

  • Woodruff, Trent R., Costantini, Kerina J., Taylor, Steve M. and Noakes, Peter G. (2008). Role of complement in motor neuron disease: Animal models and therapeutic potential of complement inhibitors. In: John D. Lambris, Current topics in complement ll. 4th Aegean Workshop on Complement Associated Diseases, Animal Models and Therapeutics, Porto Heli, Greece, (143-158). 10-17 June 2007. doi:10.1007/978-0-387-78952-1_11

  • Denny, Kerina, Woodruff, Trent, Pavlovski, Dale, Manthey, Helga, Paul Colditz, Richard Finnell and Stephen Taylor (2008). The role of C5a in reproductive impairment in the mouse and human. In: Robert Rieben, XXII International Complement Workshop. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.164

  • Proctor, Lavinia M., Woodruff, Trent M., Sharma, Prakirti, Shiels, Ian A. and Taylor, Stephen M. (2006). Transdermal pharmacology of small molecule cyclic C5a antagonists. In: Lambris, JD, 3rd Workshop on Complement Associated Diseases, Animal Models and Therapeutics, Rhodes Greece, (329-345). Jun 05-10, 2005.

  • Woodruff, T. M., Proctor, L. M., Shiels, I. A. and Taylor, S. M. (2004). A cyclic peptide, C5a receptor antagonist analogue confers increased potency in a model of inflammatory bowel disease in rats. In: Molecular immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (326-326). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002

  • Proctor, L.M., Woodruff, T.M., Pazckowski, N.P., Monk, P.N. and Taylor, S.M. (2004). Dual C3a/C5a receptor agonism by a C5a C-terminal analogue decapeptide. In: Molecular Immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (297-297). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002

  • Woodruff, T. M., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). A new C5a receptor antagonist inhibits monoarticular arthritis in the rat. In: Proceedings of the Complement Associated Diseases, Animal Models and Therapeutics Workshop. Complement Assoc. Diseases, Animal Models & Ther. Workshop, Santorini, Greece, (37-37). 10-14 October, 2001.

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.