Professor Ernst Wolvetang

Professor in Stem Cell Biology

Australian Institute for Bioengineering and Nanotechnology
e.wolvetang@uq.edu.au
+61 7 334 63894

Overview

Professor Wolvetang is an international leader in the area of pluripotent stem cell biology and human functional genomics. he initiated and leads Cell Reprogramming Australia, a collaborative framework that facilitates induced pluripotent stem cell research in Australa and is co-director of the UQ Centre in Stem Cell Ageing and Regenerative Engineering (StemCARE). He has extensive expertise in reprogramming somatic cells, differentiation and tissue engineering with adult, embryonic and induced pluripotent stem cells, genome manipulation with CRISPR, molecular biology, transcriptome analysis, high content image analysis, development and use of microfluidic devices for cell analysis, nanoparticle and scaffold design and delivery, and stem cell and cell-free regenerative medicine approaches.Professor Wolvetang has been instrumental in establishing and enabling the technology for derivation of induced pluripotent stem cells across Australia. Professor Wolvetang made the strategic decision to focus on the generation of induced pluripotent stem from patients with neurological and cardiac disorders because live human cells from such patients can usually not be obtained whereas induced pluripotent stem cells have the ability to generate every cell type of the human brain in unlimited amounts and can recapitulate the disease in the dish. Induced pluripotent stem cells combined with emerging technologies such as CRISPR-based genome editing offers a unique opportunity to study the role of individual genes and combinatorial gene regulatory pathways in the eatiology of monogenic and complex brain disorders. Indeed, combined with RNA-seq and organoid generation we are now for the first time able to gain insight into gene regulatory pathways operational in individual brain cell types of healthy and diseased individuals, investigate the connectivity and function of cells, as well as pinpoint where and when during early development such deregulated pathways lead to pathological changes. Induced pluripotent stem cells further not only provide insight into the underlying pathogenesis of neurological disorders but also constitute a valuable drugscreening platform and, following CRISPR-based gene correction, can form the basis of patient specific cellular therapies for currently incurable diseases.

Professor Wolvetang received his PhD in 1992 from the Department of Biochemistry, University of Amsterdam for his original work on peroxisomal disease (6 papers). He undertook postdoctoral studies at the Department of Biochemistry and the Institute for Reproduction and Development of Monash University, investigating apoptosis, Down syndrome and Ets transcription factors, respectively, obtaining the first evidence for an intra-chromosomal regulatory loop on chromosome 21 involving Ets2 (3 papers), and revealing the role of p53 in immune-suppression in Down syndrome (Hum Mol. Genetics). He then joined Prof Martin Pera in the Australian Stem Cell Centre in 2003 to pioneer human embryonic stem cell research in Australia, resulting in a first author Nature Biotechnology paper in 2006 identifying CD30 as a marker for genetically abnormal hESC (72 cites). He was appointed group leader of the Basic human stem cell biology laboratory in the ASCC research laboratory and senior lecturer in the Department of Anatomy and Cell biology until he accepted his current position as an independent group leader at the AIBN and Professor in stem cell biology at the University of Queensland in 2008. There he started to generate integration-free induced pluripotent stem cells from human neurological diseases such as ataxia-telangiectasia (Stem cells translational medicine). In recognition of his leadership role in this area of research he was appointed leader of the “Reprogramming and Induction of pluripotency” Collaborative Stream of the Australian Stem Cell Centre until the end of that initiative in 2011, coordinating collaborative research between eight stem cell laboratories across Australia. He subsequently initiated and is now the president of Cell Reprogramming Australia, a collaborative framework aiming to facilitate and accelerate iPS cell research in Australia and the Asia pacific region and inform the general public about reprogramming technology. His research continues to combine cell reprogramming technology, genome editing/analysis tools and microfluidic/nanoparticle based detection/ delivery technologies with the aim of creating human in vitro models of disease, unravel the underlying gene regulatory networks and enable novel cell- and delivery-based therapeutics, respectively. He further co-direct the UQ-Centre for stem cell ageing and regenerative engineering (UQ-StemCARE).

Research Interests

  • Functional human genomics
    Because iPSC can generate every cell type of the body they can be used to model a variety of diseases. CRSIPR assisted technologies can be used for functional genomics approaches. We have a particular interest in neurological diseases and generation of mini-organoids from stem cells.
  • Induced pluripotent stem cells
    Any cell from a mature organism can be reprogrammed to a pluripotent stem cell with the ability to generate any cell type of the body. This allows unprecedented possibilities to investigate disease.

Research Impacts

Memberships, patents and funding

Professor Wolvetang serves on the editorial board of six stem cell and nanotechnology journals; is listed inventor on four patents in stem cell research; and is the recipient of more than $2.5 million in grant funding in the past five years. He is a senior reprogramming scientist in Stem Cells Ltd,

Awards and plenaries

2016 Scopus Eureka Prize for Excellence in International Scientific Collaboration ,

2014 Recipient of the AON regenerative medicine prize, LSQ.

Professor Wolvetang has given 25 lectures and was invited speaker at 23 platform meetings, including multiple keynote addresses;Functional genomics approaches to human neurological diseases. Australia-China symposium. (Melbourne, October 15-18 2015) andFunctional genomics of trisomy 21. Human Genetics Society of Australia, 12th symposium (Adelaide 18 Sept 2015). He spoke at the International Society for Stem Cell Research (ISSCR) conference in Toronto, Canada in 2006; and the 2nd Annual World Congress of Regenerative Medicine & Stem Cell in Dalian, China in 2009. Professor Wolvetang organised a master-class on iPS cells at The 2nd Annual World Stem Cells & Regenerative Medicine Congress in Seoul, Korea in 2010.

Qualifications

  • Doctor of Philosophy, University of Amsterdam

Publications

  • Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017) Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 22: 5395-5407. doi:10.1523/JNEUROSCI.0525-17.2017

  • Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O'Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S. and Wolvetang, Ernst J. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific Reports, 7 . doi:10.1038/srep40127

  • Nayler, Sam, Kozlov, Sergei V., Lavin, Martin F. and Wolvetang, Ernst (2017). Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells. In Sergei V. Kozlov (Ed.), ATM kinase: methods and protocols (pp. 401-418) New York, NY, United States: Humana Press; Springer Science+Business Media. doi: 10.1007/978-1-4939-6955-5_29

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

Journal Article

  • Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017) Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 22: 5395-5407. doi:10.1523/JNEUROSCI.0525-17.2017

  • Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O'Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S. and Wolvetang, Ernst J. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific Reports, 7 . doi:10.1038/srep40127

  • Lavin, Martin F., Yeo, Abrey J., Kijas, Amanda W., Wolvetang, Ernst, Sly, Peter D., Wainwright, Claire and Sinclair, Kate (2016) Therapeutic targets and investigated treatments for Ataxia-Telangiectasia. Expert Opinion on Orphan Drugs, 4 12: 1263-1276. doi:10.1080/21678707.2016.1254618

  • Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016) Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 4: 927-947. doi:10.1189/jlb.4VMA0716-316R

  • Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016) A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 1: 109-123. doi:10.1093/hmg/ddw371

  • Titmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E. and Cooper-White, Justin J. (2016) Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays. Scientific Reports, 6 . doi:10.1038/srep24637

  • Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016) AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. PLoS One, 11 2: . doi:10.1371/journal.pone.0148213

  • Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 1: 1-222. doi:10.1080/15548627.2015.1100356

  • Klawitter, Sabine, Fuchs,Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balazs, Lower, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2016) Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature Communications, 7 1-14. doi:10.1038/ncomms10286

  • Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Alam, Intikhab, Albanese, Davide, Altschuler, Gabriel M., Arakawa, Takahiro, Archer, John A. C., Arner, Peter, Babina, Magda, Baker, Sarah, Balwierz, Piotr J., Beckhouse, Anthony G., Pradhan, Swati, Blake, Judith A., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Burroughs, A. Maxwell, Califano, Andrea, Cannistraci, Carlo V., Carbajo, Daniel, Chen, Yun, Chierici, Marco, Ciani, Yari, Clevers, Hans C., Dalla, Emiliano, Davis, Carrie A., Detmar, Michael, Diehl, Alexander D., Dohi, Taeko, Drablos, Finn, Edge, Albert S. B., Edinger, Matthias, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Fagiolini, Michela, Fairbairn, Lynsey, Fang, Hai, Farach-Carson, Mary C., Faulkner, Geoffrey J., Favorov, Alexander V., Fisher, Malcolm E., Frith, Martin C., Fujita, Rie, Fukuda, Shiro, Furlanello, Cesare, Furuno, Masaaki, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gibson, Andrew ., Gingeras, Thomas, Goldowitz, Daniel, Gough, Julian, Guhl, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Harbers, Matthias, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Takehiro, Herlyn, Meenhard, Hitchens, Kelly J., Ho Sui, Shannan J., Hofmann, Oliver M., Hoof, Ilka, Hori, Fumi, Huminiecki, Lukasz, Iida, Kei, Ikawa, Tomokatsu, Jankovic, Boris R., Jia, Hui, Joshi, Anagha, Jurman, Giuseppe, Kaczkowski, Bogumil, Kai, Chieko, Kaida, Kaoru, Kaiho, Ai, Kajiyama, Kazuhiro, Kanamori-Katayama, Mutsumi, Kasianov, Artem S., Kasukawa, Takeya, Katayama, Shintaro, Kato, Sachi, Kawaguchi, Shuji, Kawamoto, Hiroshi, Kawamura, Yuki I., Kawashima, Tsugumi, Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klinken, S. Peter, Knox, Alan J., Kojima, Miki, Kojima, Soichi, Kondo, Naoto, Koseki, Haruhiko, Koyasu, Shigeo, Krampitz, Sarah, Kubosaki, Atsutaka, Kwon, Andrew T., Laros, Jeroen F. J., Lee, Weonju, Lennartsson, Andreas, Li, Kang, Lilje, Berit, Lipovich, Leonard, Mackay, Alan, Manabe, Riichiroh, Mar, Jessica C., Marchand, Benoit, Mathelier, Anthony, Mejhert, Niklas, Meynert, Alison, Mizuno, Yosuke, de Lima Morais, David A., Morikawa, Hiromasa, Morimoto, Mitsuru., Moro, Kazuyo, Motakis, Efthymios, Motohashi, Hozumi, Mummery, Christine L., Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nakazato, Kenichi, van Nimwegen, Erik, Ninomiya, Noriko, Nishiyori, Hiromi, Noma, Shohei, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohmiya, Hiroko, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Pain, Arnab, Passier, Robert, Patrikakis, Margaret, Persson, Helena, Piazza, Silvano, Prendergast, James G. D., Rackham, Owen J. ., Ramilowski, Jordan A., Rashid, Mamoon, Ravasi, Timothy, Rizzu, Patrizia, Roncador, Marco, Roy, Sugata, Rye, Morten B., Saijyo, Eri, Sajantila, Antti, Saka, Akiko, Sakaguchi, Shimon, Sakai, Mizuho, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schneider, Claudio, Schultes, Erik A., Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sengstag, Thierry, Sheng, Guojun, Shimoji, Hisashi, Shimoni, Yishai, Shin, Jay W., Simon, Christophe, Sugiyama, Daisuke, Sugiyama, Takaaki, Suzuki, Masanori, Suzuki, Naoko, Swoboda, Rolf K., 't Hoen, Peter A.C., Tagami, Michihira, Takahashi, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tatum, Zuotian, Thompson, Mark, Toyoda, Hiroo, Toyoda, Tetsuro, Valen, Eivind, van de Wetering, Marc, van den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Vorontsov, Ilya E., Wasserman, Wyeth W., Watanabe, Shoko, Wells, Christine A., Winteringham, Louise N., Wolvetang, Ernst, Wood, Emily J., Yamaguchi, Yoko, Yamamoto, Masayuki, Yoneda, Misako, Yonekura, Yohei, Yoshida, Shigehiro, Zabierowski, Suzan E., Zhang, Peter G., Zhao, Xiaobei, Zucchelli, Silvia, Summers, Kim M., Suzuki, Harukazu, Daub, Carsten O., Kawai, Jun, Heutink, Peter, Hide, Winston, Freeman, Tom C., Lenhard, Boris, Bajic, Vladimir B., Taylor, Martin S., Makeev, Vsevolod J., Sandelin, Albin, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2015) The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 12: . doi:10.1371/journal.pbio.1002315

  • Ovchinnikov, Dmitry A., Sun, Jane and Wolvetang, Ernst J. (2015) Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectors. Methods in Molecular Biology, 1330 37-45. doi:10.1007/978-1-4939-2848-4_4

  • Briggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015) Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 5: 861-877. doi:10.1016/j.neuron.2015.09.045

  • Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015) Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 7574: 564-568. doi:10.1038/nature15695

  • Mallett, Andrew, Patel, Chirag, Maier, Barbara, McGaughran, Julie, Gabbett, Michael, Takasato, Minoru, Cameron, Anne, Trnka, Peter, Alexander, Stephen I., Rangan, Gopala, Tchan, Michel C., Caruana, Georgina, John, George, Quinlan, Cathy, McCarthy, Hugh J., Hyland, Valentine, Hoy, Wedy E., Wolvetang, Ernst, Taft, Ryan, Simons, Cas, Healy H. and Little, Melissa (2015) A protocol for the identification and validation of novel genetic causes of kidney disease. BMC Nephrology, 16 152: . doi:10.1186/s12882-015-0148-8

  • Hasegawa, Yu., Taylor, Deanne., Ovchinnikov, Dmitry A., Wolvetang, Ernst J., de Torrente, Laurence. and Mar, Jessica C. (2015) Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genetics, 11 8: . doi:10.1371/journal.pgen.1005428

  • Becherel, Olivier J., Sun, Jane, Yeo, Abrey J., Nayler, Sam, Fogel, Brent L., Gao, Fuying, Coppola, Giovanni, Criscuolo, Chiara, De Michele, Giuseppe, Wolvetang, Ernst and Lavin, Martin F. (2015) A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24 20: 5759-5774. doi:10.1093/hmg/ddv296

  • Arner, Erik, Beckhouse, Anthony, Briggs, James, Ovchinnikov, Dmitry, Wolvetang, Ernst, Wells, Christine and FANTOM Consortium (2015) Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 6225: 1010-1014. doi:10.1126/science.1259418

  • Chen, Huaying, Sun, Jane, Wolvetang, Ernst and Cooper-White, Justin (2015) High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices. Lab on a Chip, 15 4: 1072-1083. doi:10.1039/C4LC01176G

  • Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015) TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 5: 993-1006. doi:10.1091/mbc.E14-08-1290

  • Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015) ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 17: 8352-8367. doi:10.1093/nar/gkv754

  • Alateeq, Suad, Fortuna, Patrick R. J. and Wolvetang, Ernst (2015) Advances in reprogramming to pluripotency. Current Stem Cell Research and Therapy, 10 3: 193-207. doi:10.2174/1574888X10666150220154820

  • Dingwell, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015) Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 12: 1000320.1-1000320.8. doi:10.4172/2157-7633.1000320

  • Thakar, Nilay Yogeshkumar, Ovchinnikov, Dmitry Alexander, Hastie, Marcus Lachlan, Gorman, Jeffrey and Wolvetang, Ernst Jurgen (2015) RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulators. Stem Cells and Development, 24 16: 1888-1900. doi:10.1089/scd.2014.0587

  • Liang, Cong, The FANTOM Consortium, Forrest, Alistair R. R., Wagner, Guenter P., Kenna, Tony, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine and Wolvetang, Ernst (2015) The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications, 6 . doi:10.1038/ncomms7066

  • Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014) Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 12: 3278-3284. doi:10.1002/stem.1801

  • Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2014) Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cells. Journal of Clinical Medicine, 3 4: 1357-1372. doi:10.3390/jcm3041357

  • Alamein, Mohammad A., Wolvetang, Ernst J., Ovchinnikov, Dmitry A., Stephens, Sebastien, Sanders, Katherine and Warnke, Patrick H. (2014) Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.. Journal of Tissue Engineering and Regenerative Medicine, 9 9: 1078-1083. doi:10.1002/term.1960

  • Turner, Jennifer, Quek,Lake-Ee, Titmarsh, Drew, Kromer, Jens O., Kao, Li-Pin, Nielsen, Lars, Wolvetang, Ernst and Cooper-White, Justin (2014) Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations. PLoS One, 9 11: e112757.1-e112757.13. doi:10.1371/journal.pone.0112757

  • Verardo, Roberto, Piazza, Silvano, Klaric, Enio, Ciani, Yari, Bussadori, Giulio, Marzinotto, Stefania, Mariuzzi, Laura, Cesselli, Daniela, Beltrami, Antonio P., Mano, Miguel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Beltrami, Carlo A., The Fantom Consortium, Schneider, Claudio, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Fearnley, Liam, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014) Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancer. Stem Cells (Durham), 32 11: 2998-3011. doi:10.1002/stem.1791

  • Ovchinnikov, Dmitry A.,, Hidalgo, Alejandro, Yang, Seung-Kwon, Zhang, Xinli, Hudson, James, Mazzone, Stuart B., Chen, Chen, Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. Stem Cells and Development, 24 1: 11-20. doi:10.1089/scd.2014.0195

  • Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 2: 251-261. doi:10.1016/j.scr.2014.05.006

  • Mason, Elizabeth, Mar, Jessica C., Laslett, Andrew, Pera, Martin F., Quackenbush, John, Wolvetang, Ernst and Wells C. (2014) Gene expression variability as a unifying element of the pluripotency network. Stem Cell Reports, 3 2: 365-377. doi:10.1016/j.stemcr.2014.06.008

  • Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print . doi:10.1089/scd.2013.0634

  • Hasegawa, Yuki, Tang, Dave, Takahashi, Naoko, Hayashizaki, Yoshihide, Forrest, Alistair R. R., the FANTOM consortium, Suzuki, Harukazu, Blumenthal, Antje, Kenna, Tony, Briggs, James, Beckhouse, Anthony G., Hitchens, Kelly J., Ovchinnikov, Dmitry A., Vijayan, Dipti, Wells, Christine A. and Wolvetang, Ernst (2014) CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Scientific Reports, 4 Art No: 5228: . doi:10.1038/srep05228

  • Fort, Alexandre, Hashimoto, Kosuke, Yamada, Daisuke, Salimullah, Md, Keya, Chaman A., Saxena, Alka, Bonetti, Alessandro, Voineagu, Irina, Bertin, Nicolas, Kratz, Anton, Noro, Yukihiko, Wong, Chee-Hong, de Hoon, Michiel, Andersson, Robin, Sandelin, Albin, Suzuki, Harukazu, Wei, Chia-Lin, Koseki, Haruhiko, Hasegawa, Yuki, Forrest, Alistair R. R., Carninci, Piero, FANTOM Consortium, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Kenna, Tony, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine and Wolvetang, Ernst (2014) Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance. Nature Genetics, 46 6: 558-566. doi:10.1038/ng.2965

  • Ohmiya, Hiroko, Vitezic, Morana, Frith, Martin C., Itoh, Masayoshi, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Lassmann, Timo, FANTOM Consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam, Kenna, Tony and Blumenthal, Antje (2014) RECLU: a pipeline to discover reproducible transcriptional start sites and their alternative regulation using capped analysis of gene expression (CAGE). BMC Genomics, 15 . doi:10.1186/1471-2164-15-269

  • Rönnerblad, Michelle, Andersson, Robin, Olofsson, Tor, Douagi, Iyadh, Karimi, Mohsen, Lehmann, Sören, Hoof, Ilka, de Hoon, Michiel, Itoh, Masayoshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Sandelin, Albin, Ekwall, Karl, Amer, Erik, Lennartsson, Andreas, for the FANTOM consortium, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje, Kenna, Tony, Hitchens, Kelly, Ovchinnikov, Dmitry, Fearnley, Liam, Le Cao, Kim-Anh, Mason, Elizabeth, Nielsen, Lars and Vijayan, Dipti (2014) Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation. Blood, 123 17: e79-e89. doi:10.1182/blood-2013-02-482893

  • Prasad, Punit, Rönnerblad, Michelle, Arner, Erik, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Forrest, Alistair R. R., Lennartsson, Andreas, Ekwall, Karl, for the FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje and Kenna, Tony (2014) High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis. Blood, 123 17: e46-e57. doi:10.1182/blood-2013-02-483537

  • Motakis, Efthymios, Guhl, Sven, Ishizu, Yuri, Itoh, Masayoshi, Kawaji, Hideya, de Hoon, Michiel, Lassman, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Zuberbier, Torsten, Forrest, Alistair R. R., Babina, Magda, for The FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Beckhouse, Anthony, Fearnley, Liam, Hitchens, Kelly, Kenna, Tony, Le Cao, Kim-Anh, Mason, Elizabeth, Nielsen, Lars, Vijayan, Dipti, Blumenthal, Antje, Ovchinnikov, Dmitry and Briggs, James (2014) Redefinition of the human mast cell transcriptome by deep-CAGE sequencing. Blood, 123 17: 58-67. doi:10.1182/blood-2013-02-483792

  • Schmidl, Christian, Hansmann, Leo, Lassmann, Timo, Balwierz, Piotr J., Kawaji, Hideya, Itoh, Masayoshi, Kawai, Jun, Nagao-Sato, Sayaka, Suzuki, Harukazu, Andreesen, Reinhard, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Carninci, Piero, Hoffmann, Petra, Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Wells, Christine and Wolvetang, Ernst (2014) The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, 123 17: e68-e78. doi:10.1182/blood-2013-02-486944

  • Schmidl, Christian, Renner, Kathrin, Peter, Katrin, Eder, Ruediger, Lassmann, Timo, Balwierz, Piotr J., Itoh, Masayohshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Andreesen, Reinhard, Hume, David A., Hoffmann, Petra, Forrest, Alistair R. R., Kreutz, Marina P., Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014) Transcription and enhancer profiling in human monocyte subsets. Blood, 123 17: e90-e99. doi:10.1182/blood-2013-02-484188

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  • Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014) Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles 13: 1-9. doi:10.1089/scd.2013.0461

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  • Hurst, Laurence D., Sachenkova, Oxana, Daub, Carsten, Forrest, Alistair R. R., the FANTOM consortium, Huminiecki, Lukasz, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Fearnley, Liam, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014) A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators. Genome Biology, 15 7: . doi:10.1186/s13059-014-0413-3

  • Tomaru, Yasuhiro, Hasegawa, Ryota, Suzuki, Takahiro, Sato, Taiji, Kubosaki, Atsutaka, Suzuki, Masanori, Kawaji, Hideya, Forrest, Alistair R. R., Hayashizaki, Yoshihide, FANTOM Consortium, Shin, Jay W., Suzuki, Harukazu, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Fearnley, Liam, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014) A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation. Nucleic Acids Research, 42 14: 8905-8913. doi:10.1093/nar/gku567

  • Grison, Alice, Zucchelli, Silvia, Urzi, Alice, Zamparo, Ilaria, Lazarevic, Dejan, Pascarella, Giovanni, Roncaglia, Paola, Giorgetti, Alejandro, Garcia-Esparcia, Paula, Vlachouli, Christina, Simone, Roberto, Persichetti, Francesca, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Carloni, Paolo, Ferrer, Isidro, Lodovichi, Claudia, Plessy, Charles, the FANTOM Consortium, Carninci, Piero, Gustincich, Stefano, Beckhouse, Anthony, Briggs, James, Hitchens, Kelly, Kenna, Tony, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014) Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC Genomics, 15 1: . doi:10.1186/1471-2164-15-729

  • Polanco, Juan Carlos, Ho, Mirabelle S. H., Wang, Bei, Zhou, Qi, Wolvetang, Ernst, Mason, Elizabeth, Wells, Christine A., Kolle, Gabriel, Grimmond, Sean M., Bertoncello, Ivan, O'Brien, Carmel and Laslett, Andrew L. (2013) Identification of Unsafe Human Induced Pluripotent Stem Cell Lines Using a Robust Surrogate Assay for Pluripotency. Stem Cells, 31 8: 1498-1510. doi:10.1002/stem.1425

  • Titmarsh, Drew M., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2013) Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays. Biotechnology Journal, 8 7: 822-834. doi:10.1002/biot.201200375

  • Guan, Jun-Lin, Simon, Anna Katharina, Prescott, Mark, Menendez, Javier A., Liu, Fei, Wang, Fen, Wang, Chenran, Wolvetang, Ernst, Vazquez-Martin, Alejandro and Zhang, Jue (2013) Autophagy in stem cells. Autophagy, 9 6: 830-849. doi:10.4161/auto.24132

  • Briggs, James A., Mason, Elizabeth A., Ovchinnikov, Dmitry A., Wells, Christine A. and Wolvetang, Ernst J. (2013) Concise review: new paradigms for down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Translational Medicine, 2 3: 175-184. doi:10.5966/sctm.2012-0117

  • Briggs, James A., Sun, Jane, Shepherd, Jill, Ovchinnikov, Dmitry A., Chung, Tung-Liang, Nayler, Sam P., Kao, Li-Pin, Morrow, Carl A., Thakar, Nilay Y., Soo, Set-Yen, Peura, Teija, Grimmond, Sean and Wolvetang, Ernst J. (2013) Integration-free induced pluripotent stem cells model genetic and neural developmental features of Down Syndrome etiology. Stem Cells, 31 3: 467-478. doi:10.1002/stem.1297

  • Titmarsh, Drew M., Chen, Huaying, Wolvetang, Ernst J. and Cooper-White, Justin J. (2013) Arrayed cellular environments for stem cells and regenerative medicine. Biotechnology Journal, 8 2: 167-179. doi:10.1002/biot.201200149

  • Menzies, Donna J., Cameron, Andrew, Munro, Trent, Wolvetang, Ernst, Grondahl, Lisbeth and Cooper-White, Justin J. (2013) Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels. Biomacromolecules, 14 2: 413-423. doi:10.1021/bm301652q

  • Barry, Guy, Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Vikram Ratnu, Nayler, S. P., Nones, K., Hu, J., Timothy Bredy, Nakagawa, S., Rigo, F., Taft, R. J., Cairns, M. J., Blackshaw, S., Wolvetang, E. J. and Mattick, J. S. (2013) The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry, 19 4: 486-494. doi:10.1038/mp.2013.45

  • Filippich, Cheryl, Wolvetang, Ernst J. and Mowry, Bryan J. (2013) Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?. Schizophrenia Bulletin, 39 5: 948-954. doi:10.1093/schbul/sbt103

  • Titmarsh, Drew M., Hudson, James E., Hidalgo, Alejandro, Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012) Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One, 7 12: e52405.1-e52405.12. doi:10.1371/journal.pone.0052405

  • Ovchinnikov, Dmitry A., Cooper, Matthew A., Pandit, Pratibala, Coman, William B., Cooper-White, Justin J., Keith, Patricia, Wolvetang, Ernst J., Slowey, Paul D. and Punyadeera, Chamindie (2012) Tumor-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients. Translational Oncology, 5 5: 321-326. doi:10.1593/tlo.12232

  • Jaramillo-Ferrada, Pamela A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012) Differential mesengenic potential and expression of stem cell-fate modulators in mesenchymal stromal cells from human-term placenta and bone marrow. Journal of Cellular Physiology, 227 9: 3234-3242. doi:10.1002/jcp.24014

  • Vitale, Alejandra M., Matigian, Nicholas A., Ravishankar, Sugandha, Bellette, Bernadette, Wood, Stephen A., Wolvetang, Ernst J. and Mackay-Sim, Alan (2012) Variability in the Generation of Induced Pluripotent Stem Cells: Importance for Disease Modeling. Stem Cells Translational Medicine, 1 9: 641-650. doi:10.5966/sctm.2012-0043

  • Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012) Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 12: 2288-2297. doi:10.1089/scd.2011.0608

  • Nayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012) Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 7: 523-535. doi:10.5966/sctm.2012-0024

  • Hudson, James, Titmarsh, Drew, Hidalgo, Alejandro, Wolvetang, Ernst and Cooper-White, Justin (2012) Primitive cardiac cells from human embryonic stem cells. Stem Cells and Development, 21 9: 1513-1523. doi:10.1089/scd.2011.0254

  • Kao, Li-Pin, Ovchinnikov, Dmitry and Wolvetang, Ernst (2012) The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicology and Applied Pharmacology, 261 1: 42-49. doi:10.1016/j.taap.2012.03.009

  • Chen, Yen Shun, Pelekanos, Rebecca A., Ellis, Rebecca L., Horne, Rachel, Wolvetang, Ernst J. and Fisk, Nicholas M. (2012) Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells. Stem Cells Translational Medicine, 1 2: 83-95. doi:10.5966/sctm.2011-0022

  • Sin, Dongchoon, Fitzpatrick, Jane, Luckman, Paul, Wolvetang, Ernst J. and Cooper-White, Justin J. (2012) Fabrication of nanopatterned, porous microspheres using a glass capillary microfluidic device. Soft Matter, 8 41: 10712-10718. doi:10.1039/c2sm25950h

  • Titmarsh, Drew, Hidalgo, Alejandro, Turner, Jennifer, Wolvetang, Ernst and Cooper-White, Justin (2011) Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors. Biotechnology and Bioengineering, 108 12: 2894-2904. doi:10.1002/bit.23260

  • Tra, Thien, Gong, Lan, Kao, Lin-Pin, Li, Xue-Lei, Grandela, Catarina, Devenish, Rodney J., Wolvetang, Eernst and Prescott, Mark (2011) Autophagy in human embryonic stem cells. PLoS One, 6 11: e27485.1-e27485.7. doi:10.1371/journal.pone.0027485

  • Hudson, James E., Brooke, Gary, Blair, Chris, Wolvetang, Ernst and Cooper-White, Justin John (2011) Development of myocardial constructs using modulus-matched acrylated polypropylene glycol triol substrate and different nonmyocyte cell populations. Tissue Engineering Part A: Tissue Engineering, 17 17-18: 2279-2289. doi:10.1089/ten.tea.2010.0743

  • Hudson, James E., Mills, Richard J., Frith, Jessica E., Brooke, Gary, Jaramillo-Ferrada, Pamela, Wolvetang, Ernst J. and Cooper-White, Justin J. (2011) A defined medium and substrate for expansion of human mesenchymal stromal cell progenitors that enriches for osteo- and chondrogenic precursors. Stem Cells and Development, 20 1: 77-87. doi:10.1089/scd.2009.0497

  • Chung, Tung-Liang, Thaker, Nilay Y. and Wolvetang, Ernst J. (2011) Genetic and epigenetic instability of human pluripotent stem cells. The Open Stem Cell Journal, 3 52-61. doi:10.2174/1876893801103010052

  • Vitale, Alejandra M., Wolvetang, Ernst and Mackay-Sim, Alan (2011) Induced pluripotent cells: a new technology to study human diseases. The International Journal of Biochemistry and Cell Biology, In press 6: 843-846. doi:10.1016/j.biocel.2011.03.013

  • Hudson, James E., Frith, Jessica E., Donose, Bogdan C., Rondeau, Elisabeth, Mills, Richard J., Wolvetang, Ernst J., Brooke, Gary P. and Cooper-White, Justin J. (2010) A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications. Biomaterials, 31 31: 7937-7947. doi:10.1016/j.biomaterials.2010.07.007

  • Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010) Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 32: 8281-8288. doi:10.1016/j.biomaterials.2010.07.037

  • Chung, Tung-Liang, Turner, Jennifer P., Thaker, Nilay Y., Kolle, Gabriel, Cooper-White, Justin J., Grimmond, Sean M., Pera, Martin F. and Wolvetang, Ernst J. (2010) Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells. Stem Cells, 28 10: 1782-1793. doi:10.1002/stem.500

  • Chung, TL, Brena, RM, Kolle, G, Grimmond, SM, Berman, BP, Laird, PW, Pera, MF and Wolvetang, EJ (2010) Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells, 28 10: 1848-1855. doi:10.1002/stem.493

  • Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010) Defined high protein content surfaces for stem cell culture. Biomaterials, 31 19: 5137-5142. doi:10.1016/j.biomaterials.2010.03.015

  • Prowse, ABJ, Wilson, J, Osborne, GW, Gray, PP and Wolvetang, EJ (2009) Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers. Stem Cells and Development, 18 8: 1135-1139. doi:10.1089/scd.2009.0080

  • Hannan, N.R.F., Jamshidi, P., Pera, M.F. and Wolvetang, E.J. (2009) BMP-11 and Myostatin Support Undifferentiated Growth of Human Embryonic Stem Cells in Feeder-Free Cultures. Cloning and Stem Cells, 11 3: 427-435. doi:10.1089/clo.2009.0024

  • Grandela, C., Pera, M. F., Grimmond, S. M., Kolle, G. and Wolvetang, E. J. (2009) Corrigendum to "p53 is required for etoposide-induced apoptosis of human embryonic stem cells" [Stem Cell Research 1 (2008) 116-128]. Stem Cell Research, 3 2-3: 179-179. doi:10.1016/j.scr.2008.12.001

  • Prowse, ABJ, Wolvetang, EJ and Gray, PP (2009) A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps. Biotechniques, 47 1: 599-606. doi:10.2144/000113151

  • Hannan, Nicholas R.F. and Wolvetang, Ernst J. (2009) Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus. Stem Cells Development, 18 4: 653-660. doi:10.1089/scd.2008.0160

  • Cullinane, Meabh, Gong, Lan, Lazar-Adler, Natalie, Tra, Thien, Wolvetang, Ernst, Prescott, Mark, Boyce, John D., Devenish, Rodney J. and Adler, Ben (2008) Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines. Autophagy, 4 6: 744-753.

  • Grandela, C., Pera, M. F. and Wolvetang, E. J. (2008) p53 is required for etoposide-induced apoptosis of human embryonic stem cells. Stem Cell Research, 1 2: 116-128. doi:10.1016/j.scr.2007.10.003

  • Wolvetang, Ernst J., Pera, Martin F. and Zuckerman, Kenneth S. (2007) Gap junction mediated transport of shRNA between human embryonic stem cells. Biochemical and biophysical research communications, 363 3: 610-615. doi:10.1016/j.bbrc.2007.09.035

  • Grandela, C. and Wolvetang, E. (2007) hESC Adaptation, Selection and Stability. Stem Cell Reviews and Reports, 3 3: 183-191. doi:10.1007/s12015-007-0008-4

  • Herszfeld, Daniella, Wolvetang, Ernst, Langton-Bunker, Emma, Chung, Tung-Liang, Filipczyk, Adam A,, Houssami, Souheir, Pegah Jamshid, Koh, Karen, Laslett, Andrew L., Anna Michalska, Nguyen, Linh, Reubinoff, Benjamin E., Tellis, Irene, Auerbach, Jonathan M., Ording, Carol J., Looijenga, Leendert H. J. and Pera, Martin F. (2006) CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nature Biotechnology, 24 3: 351-357. doi:10.1038/nbt1197

  • Pebay, Alice, Wong, Raymond C. B., Pitson, Stuart M., Wolvetang, Ernst J., Peh, Gary S.-L., Fykilipcz, Adam, Koh, Karen L. L., Tellis, Irene, Nguyen, Linh T.V. and Pera, Martin F. (2005) Essential Roles of Sphingosine-1-Phosphate and Platelet-Derived Growth Factor in the Maintenance of Human Embryonic Stem Cells. Stem Cells, 23 10: 1541-1548. doi:10.1634/stemcells.2004-0338

  • Helguera, Pablo, Pelsman, Alejandra, Pigino, Gustavo, Wolvetang, Ernst, Head, Elizabeth and Busciglio, Jorge (2005) ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. Journal of Neuroscience, 25 9: 2295-2303. doi:10.1523/JNEUROSCI.5107-04.2005

  • Thouas, George, A., Trounson, Alan O., Wolvetang, Ernst J. and Jones, Gayle M. (2004) Mitochondrial Dysfunction in Mouse Oocytes Results in Preimplantation Embryo Arrest in Vitro full access. Biology of Reproduction, 71 6: 1936-1942. doi:10.1095/biolreprod.104.033589

  • Wolvetang, E. W., Bradfield, O. M., Tymms, M., Zavarsek, S., Hatzistavrou, T., Kola, I. and Hertzog, P. J. (2003) The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: Implications for Down syndrome. Biochimica et biophysica acta (BBA). Gene structure and expression, 1628 2: 105-110. doi:10.1016/S0167-4781(03)00121-0

  • Ohtani, Naoko, Brennan, Paul, Gaubatz, Stefan, Sanij, Elaine, Hertzog, Paul, Wolvetang, Ernst, Ghysdael, Jacques, Rowe, Martin and Hara, Eiji (2003) Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5. Journal of Cell Biology, 162 2: 173-183. doi:10.1083/jcb.200302085

  • Leech, Michelle, Lacey, Derek, Santos, leilani, Hutchinson, Paul, Wolvetang, Ernst, David, John R., Bucala, Richard and Morand, Eric F. (2003) Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis & Rheumatism, 48 7: 1881-1889. doi:10.1002/art.11165

  • Sanij, Elaine, Scott, Bernadette, Wilson, Trevor, Xu, Dakang, Hertzog, Paul and Wolvetang, Ernst (2003) Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein. Immunology Letters, 86 1: 63-70. doi:10.1016/S0165-2478(02)00258-4

  • Wolvetang, E. J., Wilson, T. J., Sanij, E., Busciglio, J., Hatzistavrou, T., Hertzog, P. J. and Kola, I. (2003) ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human Molecular Genetics, 12 3: 247-255. doi:10.1093/hmg/ddg015

  • Wolvetang, E. J., Bradfield, O. M., Hatzistavrou, T., Crack, P. J., Busciglio, J., Kola, I. and Hertzog, P. J. (2003) Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of Disease, 14 3: 349-356. doi:10.1016/S0969-9961(03)00107-4

  • Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I. and Wolvetang, E. J. (2001) Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's Syndrome. Biochemical and Biophysical Research Communications, 287 4: 1003-1008. doi:10.1006/bbrc.2001.5680

  • Lazner, F., Wolvetang, E. J., Lazner, D. and Hertzog, P. (2001) Bone disease: Current knowledge and future prospects. Current Genomics, 2 91-124.

  • Hertzog, P. J., Pritchard, ., Wolvetang, E., Wilson, T., Owczarek, C. M. and Kola, I. (2001) Function of two gene families on human chromosome 21 and their potential contribution to Down syndrome. Cytogenetics and Cell Genetics, 92 1-2: 12-12.

  • Lacey, D. C., YH, Yang, Hutchinson, P,, Wolvetang, E,, Leech, M, and Morand, E. F. (2001) Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes. Arthritis and Rheumatism, 49 4: S158-S158.

  • Bladier, C, Wolvetang, EJ, Hutchinson, P, deHaan, JB and Kola, I (1997) Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis. Cell Growth & Differentiation, 8 5: 589-598.

  • Vaillant, F, Larm, JA, McMullen, GL, Wolvetang, EJ and Lawen, A (1996) Effecters of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators. Journal of Bioenergetics and Biomembranes, 28 6: 531-540. doi:10.1007/BF02110443

  • Wolvetang, EJ, Larm, JA, Moutsoulas, P and Lawen, A (1996) Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth & Differentiation, 7 10: 1315-1325.

  • Grubb, DR, Wolvetang, EJ and Lawen, A (1995) Didemnin-B Induces Cell-Death by Apoptosis - the Fastest Induction of Apoptosis Ever Described. Biochemical and Biophysical Research Communications, 215 3: 1130-1136. doi:10.1006/bbrc.1995.2580

  • Larm, JA, Wolvetang, EJ, Vaillant, F, Martinus, RD, Lawen, A and Linnane, AW (1995) Increase of Plasma-Membrane Oxidoreductase Activity Is Not Correlated with the Production of Extracellular-Superoxide Radicals in Human Namalwa Cells. Protoplasma, 184 1-4: 173-180. doi:10.1007/BF01276917

  • Wolvetang, EJ, Johnson, KL, Krauer, K, Ralph, SJ and Linnane, AW (1994) Mitochondrial Respiratory-Chain Inhibitors Induce Apoptosis. Febs Letters, 339 1-2: 40-44. doi:10.1016/0014-5793(94)80380-3

  • Lawen, A, Martinus, RD, McMullen, GL, Nagley, P, Vaillant, F, Wolvetang, EJ and Linnane, AW (1994) The Universality of Bioenergetic Disease - the Role of Mitochondrial Mutation and the Putative Interrelationship Between Mitochondria and Plasma-Membrane Nadh Oxidoreductase. Molecular Aspects of Medicine, 15 13-27.

  • Wolvetang, EJ, Tager, JM and Wanders, Rja (1991) Factors Influencing the Latency of the Peroxisomal Enzyme Dihydroxyacetone-Phosphate Acyltransferase (Dhap-At) in Permeabilized Human Skin Fibroblasts. Biochimica Et Biophysica Acta, 1095 2: 122-126. doi:10.1016/0167-4889(91)90074-8

  • Wolvetang, EJ, Tager, JM and Wanders, Rja (1990) Latency of the Peroxisomal Enzyme Acyl-Coa-Dihydroxyacetonephosphate Acyltransferase in Digitonin-Permeabilized Fibroblasts - the Effect of Atp and Atpase Inhibitors. Biochemical and Biophysical Research Communications, 170 3: 1135-1143. doi:10.1016/0006-291X(90)90511-K

  • Wolvetang, EJ, Wanders, Rja, Schutgens, Rbh, Berden, JA and Tager, JM (1990) Properties of the Atpase Activity Associated with Peroxisome-Enriched Fractions From Rat-Liver - Comparison with Mitochondrial F1F0-Atpase. Biochimica Et Biophysica Acta, 1035 1: 6-11. doi:10.1016/0304-4165(90)90166-T

  • Caro, Lhp, Plomp, Pjam, Wolvetang, EJ, Kerkhof, C and Meijer, AJ (1988) 3-Methyladenine, An Inhibitor of Autophagy, Has Multiple Effects On Metabolism. European Journal of Biochemistry, 175 2: 325-329. doi:10.1111/j.1432-1033.1988.tb14200.x

  • Plomp, Pjam, Wolvetang, EJ, Groen, AK, Meijer, AJ, Gordon, PB and Seglen, PO (1987) Energy-Dependence of Autophagic Protein-Degradation in Isolated Rat Hepatocytes. European Journal of Biochemistry, 164 1: 197-203. doi:10.1111/j.1432-1033.1987.tb11011.x

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision