Dr Shyuan Ngo

Scott Sullivan Research Fellow in M

Australian Institute for Bioengineering and Nanotechnology

Affiliate Research Fellow

UQ Centre for Clinical Research
Faculty of Medicine
s.ngo@uq.edu.au
+61 7 344 31133

Overview

I completed my undergraduate and PhD training at UQ. After completing my PhD in 2009, I took up a postdoctoral position at UQCCR to introduce a translational edge to my research program. In 2012, I was awarded a Bill Gole Postdoctoral Research Fellowship from the Motor Neurone Disease Research Institute of Australia (MNDRIA). I returned to the School of Biomedical Sciences with this fellowship to continue my research program in motor neuron disease (MND). In 2015, I was awarded the Scott Sullivan MND Research Fellowship. In this position, I conduct research between the Queensland Brain Institute and the School of Biomedical Sciences at UQ and the Royal Brisbane and Women's Hospital to address how changes in energy metabolism affects the course of MND, whilst working to develop therapies for MND.

My primary research focus is to understand the causes and consequences of metabolic dysfunction in MND. I am particularly interested in identifying which metabolic pathways are disrupted in MND/ALS and how targeting these pathways might correct for defective energy balance, and prolong survival. I collaborate with international researchers and neurologists in Paris, Strasbourg, and Utrecht, and with a strong clinical team at the Royal Brisbane & Women’s hospital with the broader goal of translating basic research to the clinic. In collaboration with researchers in China, I am also interested in investigating how induced pluripotent stem cells may be used as a therapeutic avenue in MND.

Research Interests

  • Metabolic Dysfunction in Motor Neuron Disease/Amyotrophic Lateral Sclerosis
  • Biomarkers in Motor Neuron Disease/Amyotrophic Lateral Sclerosis
  • Neuromuscular Junction Formation, Maintenance and Stability

Qualifications

  • Doctor of Philosophy, The University of Queensland

Publications

  • Steyn, Frederik J. and Ngo, Shyuan T. (2017) Endocrine rhythms of growth hormone release: insights from animal studies. Best Practice and Research: Clinical Endocrinology and Metabolism, 31 6: 521-533. doi:10.1016/j.beem.2017.10.009

  • Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, McCann, Emily P., Mowry, Bryan J., Ngo, Shyuan T., Pamphlett, Roger, Ran, Shu, Reutens, David C., Rowe, Dominic B., Sachdev, Perminder, Shah, Sonia, Song, Sharon, Tan, Li-Jun, Tang, Lu, van den Berg, Leonard H., van Rheenen, Wouter, Veldink, Jan H., Wallace, Robyn H., Wheeler, Lawrie, Williams, Kelly L., Wu, Jinyu, Wu, Xin, Yang, Jian, Yue, Weihua, Zhang, Zong-Hong, Zhang, Dai, Noakes, Peter G., Blair, Ian P., Henderson, Robert D., McCombe, Pamela A., Visscher, Peter M., Xu, Huji, Bartlett, Perry F., Brown, Matthew A., Wray, Naomi R. and Fan, Dongsheng (2017) Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 1: . doi:10.1038/s41467-017-00471-1

  • Ngo, Shyuan T., Mi, Jia D., Henderson, Robert D., McCombe, Pamela A. and Steyn, Frederik J. (2017) Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease, 7 95-108. doi:10.2147/DNND.S120607

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) is a neurodegenerative disease that is characterised by the degeneration of both upper and lower alpha motor neurons. The irreversible loss of neurons in the brain and spinal cord results in progressive skeletal muscle paralysis and death within 2-5 years of diagnosis. There is no known cure for the disease, and treatments are of limited benefit. In the absence of a cure for MND/ALS, there is a pressing need to lessen the severity of symptoms associated with, and to slow the progression of disease, whilst enhancing quality of life.

    While the fundamental mechanisms that underlie the development of MND/ALS remains unknown, recent studies suggest that defective regulation of energy homeostasis may exacerbate the degenerative process throughout the course of disease. This project investigates how altered glucose and fatty acid metabolism contributes to the progression of MND/ALS.

View all Available Projects

Publications

Book Chapter

  • Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. In Ronald Ross Watson and Victor R. Preedy (Ed.), Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy (pp. 355-361) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-411462-3.00036-9

  • Ngo, Shyuan T. and Bellingham, Mark C. (2013). Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice. In Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y. (Ed.), Stimulation and inhibition of neurons (pp. 225-235) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-233-9_13

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) is a neurodegenerative disease that is characterised by the degeneration of both upper and lower alpha motor neurons. The irreversible loss of neurons in the brain and spinal cord results in progressive skeletal muscle paralysis and death within 2-5 years of diagnosis. There is no known cure for the disease, and treatments are of limited benefit. In the absence of a cure for MND/ALS, there is a pressing need to lessen the severity of symptoms associated with, and to slow the progression of disease, whilst enhancing quality of life.

    While the fundamental mechanisms that underlie the development of MND/ALS remains unknown, recent studies suggest that defective regulation of energy homeostasis may exacerbate the degenerative process throughout the course of disease. This project investigates how altered glucose and fatty acid metabolism contributes to the progression of MND/ALS.