Professor Pamela McCombe

Professor

UQ Centre for Clinical Research
Faculty of Medicine

Affiliate Professor

Royal Brisbane Clinical Unit
Faculty of Medicine
pamela.mccombe@uq.edu.au
+61 7 334 66017

Overview

Neurologist

Dr McCombe graduated in Medicine from UQ and completed a Science degree for medical students. She then trained as a neurologist in Sydney, at Prince Henry and Prince of Wales Hospitals. She obtained a PhD from the University of Sydney. She obtained experience in Neurophysiology in Cleveland and then returned to UQ as a post-doctoral fellow. She worked for some years as a research fellow in Neuroimmunology and was an NHMRc SRF. Later she resumed clinical practice as a neurologist, and contimued her research as an NHMRC Practitioner Fellow. She is currentlyProfessor and Head of the Royal Brisbane Clinical school in the School of Medicine and Co-head of the Brain and Mental Health Theme at the UQ Centre for Clinical Research.

Research Interests

  • Biomarkers in ALS
    This is a collaborative project wih Dr Rob Henderson, Prof Tony Pettit and Dr Gareth Ridall- looking at motor unit number estimation in ALS
  • Inflammatory neuropathy
    This is an ongoing study of the immunological basis of acute and chronic inflammatory neuropathy
  • Pregnancy and EAE
    this study will investigate the effects of pregnancy on the clinical course of EAE, an experimental disae that is a model of multiple sclerosis
  • Immunology of stroke
    This study involves documenting the immune responses after human stroke and determining the significance of these responses.

Qualifications

  • FRACP
  • PhD, The University of Sydney
  • BSc, The University of Queensland
  • MBBS, The University of Queensland

Publications

  • Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, McCann, Emily P., Mowry, Bryan J., Ngo, Shyuan T., Pamphlett, Roger, Ran, Shu, Reutens, David C., Rowe, Dominic B., Sachdev, Perminder, Shah, Sonia, Song, Sharon, Tan, Li-Jun, Tang, Lu, van den Berg, Leonard H., van Rheenen, Wouter, Veldink, Jan H., Wallace, Robyn H., Wheeler, Lawrie, Williams, Kelly L., Wu, Jinyu, Wu, Xin, Yang, Jian, Yue, Weihua, Zhang, Zong-Hong, Zhang, Dai, Noakes, Peter G., Blair, Ian P., Henderson, Robert D., McCombe, Pamela A., Visscher, Peter M., Xu, Huji, Bartlett, Perry F., Brown, Matthew A., Wray, Naomi R. and Fan, Dongsheng (2017) Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 1: 611-611. doi:10.1038/s41467-017-00471-1

  • Bukhari, Wajih, Prain, Kerri M., Waters, Patrick, Woodhall, Mark, O'Gorman, Cullen M., Clarke, Laura, Silvestrini, Roger A., Bundell, Christine S., Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brown, Matthew, Brownlee, Wallace J., Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Dear, Keith, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P. D., Heshmat, Saman, Hodgkinson, Suzanne, Jimenez-Sanchez, Sofia, Killpatrick, Trevor, King, John, Kneebone, Christopher, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming-Wei, Lynch, Christpher, Macdonell, Richard, Mason, Deborah F., McCombe, Pamela A., Pender, Michael P., Pereira, Jennifer A., Pollard, John D., Reddel, Stephen W., Shaw, Cameron, Spies, Judith, Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G., Marriott, Mark P., Parratt, John D. E., Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Wilson, Robert J., Vincent, Angela and Broadley, Simon A. (2017) Incidence and prevalence of NMOSD in Australia and New Zealand. Journal of Neurology Neurosurgery and Psychiatry, 88 8: 632-638. doi:10.1136/jnnp-2016-314839

  • Ngo, Shyuan T., Mi, Jia D., Henderson, Robert D., McCombe, Pamela A. and Steyn, Frederik J. (2017) Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease, 7 95-108. doi:10.2147/DNND.S120607

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. In Ronald Ross Watson and Victor R. Preedy (Ed.), Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy (pp. 355-361) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-411462-3.00036-9

  • McCombe, Pamela A. and Greer, Judith M. (2014). Sexual dimorphism in the immune system. In Ian R. Mackay and Noel R. Rose (Ed.), The Autoimmune Diseases 5th ed. (pp. 319-328) San Diego, United States: Academic Press. doi:10.1016/B978-0-12-384929-8.00024-1

Journal Article

Conference Publication

  • Xu, Zhouwei, Alruwaili, Ashwag, Henderson, Robert and McCombe, Pamela (2017). SCREENING FOR COGNITIVE AND BEHAVIOURAL IMPAIRMENT IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS: FREQUENCY OF ABNORMALITY AND EFFECT ON SURVIVAL. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast Australia, (). May 09-12, 2017. doi:10.1136/jnnp-2017-316074.29

  • Steyn, Frederik J., Restuadi, Restuadi, Ioannides, Zara, Ngo, Shyuan T., McRae, Allan, Wray, Naomi R., Henderson, Robert and McCombe, Pamela (2017). Comparison of Faecal Microbe Diversity Between Motor Neurone Disease (Mnd) and Control Participants. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast, Australia, (). May 09-12, 2017. doi:10.1136/jnnp-2017-316074.81

  • Xu, Zhouwei, Lee, Aven, Henderson, Robert and McCombe, Pamela (2017). Gelsolin, clusterin and Cd5L are the potential plasma biomarkers of amyotrophic lateral sclerosis with and without cognitive impairment. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast, Australia, (). 9-12 May 2017. doi:10.1136/jnnp-2017-316074.34

  • Ioannides, Zara A., Ngo, Shyuan T., Henderson, Robert D., McCombe, Pamela A. and Steyn, Frederik J. (2017). Hypermetabolism in Motor Neurone Disease Is Associated with a Greater Functional Decline But Not Weight Loss. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast, Australia, (). May 09-12, 2017. doi:10.1136/jnnp-2017-316074.18

  • Ioannides, Zara A., Steyn, Frederik J., Henderson, Robert D., McCombe, Pamela A. and Ngo, Shyuan T. (2017). The risk of overestimating fatness in motor neurone disease: longitudinal assessments of body composition. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast, Australia, (e.13-e.14). 9-12 May 2017. doi:10.1136/jnnp-2017-316074.35

  • Merkel, Bernd, Jokubaitis, Vilija, Spelman, Tim, Lechner-Scott, Jeannette, McCombe, Pamela, Slee, Mark, Vucic, Steve, Skibina, Olga, Barnett, Michael, Hodgkinson, Suzanne, Butzkueven, Helmut and Kalincik, Tomas (2017). Timing of High-Efficacy Disease Modifying Therapies for Relapsing-Remitting Multiple Sclerosis. In: Annual Scientific Meeting of the Australian-and-New-Zealand-Association-of-Neurologists (ANZAN), Gold Coast, Australia, (). May 09-12, 2017. doi:10.1136/jnnp-2017-316074.16

  • McCombe, P. A., Hartung, H-P, Havrdova, E., Selmaj, K. W., Margolin, D. H., Kasten, L. and Compston, D. A. S. (2016). Durable Effect of Alemtuzumab on Clinical Outcomes Over 5 years in Treatment-Naive Patients With Active Relapsing-Remitting Multiple Sclerosis Despite Most Patients Not Receiving Treatment for 4 Years: CARE-MS I Extension Study. In: Multiple Sclerosis Journal. 8th Congress of the Pan-Asian-Committee-for-Research-and-Treatment-of-Multiple-Sclerosis (PACTRIMS), Seoul South Korea, (406-407). Nov 19-21, 2015.

  • McCombe, P., Achiron, A., Chambers, C., Fox, E. J., Otero, S., Margolin, D. H., Kasten, L. and Compston, D. A. S. (2016). Pregnancy Outcomes in Alemtuzumab-Treated Female Patients with Active RRMS in the Clinical Development Program.. In: Multiple Sclerosis Journal. 8th Congress of the Pan-Asian-Committee-for-Research-and-Treatment-of-Multiple-Sclerosis (PACTRIMS), Seoul South Korea, (420-421). Nov 19-21, 2015.

  • Coles, A. J., Boyko, A. N., Cohen, J. A., De Seze, J., Fox, E. J., Havrdova, E., Hartung, H. -P., Inshasi, J. S., McCombe, P., Selmaj, K. W., Vermersch, P., Van Wijmeersch, B., Margolin, D. H., Thangavelu, K., Rodriguez, C. E. and Montalban, X. (2016). Alemtuzumab provides durable improvements in clinical outcomes in treatment-naive patients with active relapsing-remitting multiple sclerosis over 6 years in the absence of continuous treatment (CARE-MS I).. In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (75-76). Sep 14-17, 2016.

  • Kalincik, T., Lizak, N., Jokubaitis, V., Butler, E., Lechner-Scott, J., Slee, M., McCombe, P., Shaw, C., Skibina, O., Vucic, S., Shuey, N., Barnett, M., Parratt, J., Butzkueven, H. and Hodgkinson, S. (2016). Australian cladribine experience. In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (289-290). Sep 14-17, 2016.

  • Kalincik, T., Brown, J. W., Robertson, N., Willis, M., Scolding, N., Pearson, O., Ziemssen, T., Hutchinson, M., McGuigan, C., Jokubaitis, V., Spelman, T., Horakova, D., Havrdova, E., Trojano, M., Izquierdo, G., Lugaresi, A., Prat, A., Girard, M., Duquette, P., Grammond, P., Alroughani, R., Pucci, E., Sola, P., Hupperts, R., Lechner-Scott, J., Fernandez Bolanos, R., Terzi, M., Van Pesch, V., Rozsa, C., Grand'Maison, F., Boz, C., Granella, F., Slee, M., Spitaleri, D., Olascoaga, J., Bergamaschi, R., Iuliano, G., Verheul, F., Vucic, S., McCombe, P., Hodgkinson, S., Kovacs, K., Sanchez-Menoyo, J. L., Ampapa, R., Simo, M., Ramo, C., Cristiano, E., Barnett, M., Butzkueven, H. and Coles, A. (2016). Comparison of 5-year treatment outcomes between alemtuzumab versus natalizumab, fingolimod and interferon beta-1a. In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (829-832). Sep 14-17, 2016.

  • Oreja-Guevara, C., Alroughani, R., Brassat, D., Boyko, A. N., McCombe, P., Steingo, B., Van Wijmeersch, B., Margolin, D. H., Thangavelu, K., Rodriguez, C. E. and Vermersch, P. (2016). Durable improvement in clinical outcomes in treatmentnaive patients with relapsing-remitting multiple sclerosis who switched from SC IFNB-1a to alemtuzumab (care-MS I extension study 4-year follow-up). In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (648-649). Sep 14-17, 2016.

  • Kalincik, T., Sobisek, L., Jokubaitis, V., Spelman, T., Horakova, D., Havrdova, E., Trojano, M., Izquierdo, G., Lugaresi, A., Girard, M., Prat, A., Duquette, P., Grammond, P., Sola, P., Hupperts, R., Grand'Maison, F., Pucci, E., Boz, C., Alroughani, R., Van Pesch, V., Lechner-Scott, J., Terzi, M., Bergamaschi, R., Iuliano, G., Granella, F., Spitaleri, D., Shaygannejad, V., Oreja-Guevara, C., Slee, M., Ampapa, R., Verheul, F., McCombe, P., Olascoaga, J., Amato, M. P., Vucic, S., Hodgkinson, S., Ramo, C., Flechter, S., Cristiano, E., Rozsa, C., Moore, F., Sanchez-Menoyo, J. L., Saladino, M. L., Barnett, M. and Butzkueven, H. (2016). Individual response to disease modifying therapies: a global observational cohort study. In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (358-360). Sep 14-17, 2016.

  • Rog, David, Chambers, Christina, McCombe, Pamela, Otero, Susana, Hellwig, Kerstin, Margolin, David, Thangavelu, Karthinathan and Oh, Jiwon (2016). Pregnancy Outcomes in Alemtuzumab-Treated Patients with Rrms. In: Annual Meeting of the Association-of-British-Neurologists (ABN), Brighton, England, (). May 17-19, 2016. doi:10.1136/jnnp-2016-315106.155

  • Jokubaitis, V. G., Kalincik, T., Lorscheider, J., Spelman, T., Horakova, D., Duquette, P., Girard, M., Prat, A., Izquierdo, G., Grammond, P., Pucci, E., Grand'Maison, F., Granella, F., Sola, P., Bergamaschi, R., Iuliano, G., Spitaleri, D., Hodgkinson, S., Olascoaga, J., Verheul, F., McCombe, P., Rozsa, C., Lechner-Scott, J., Terzi, M., Hughes, S., Saladino, M. -L., Lugaresi, A., Trojano, M. and Butzkueven, H. (2016). Pregnancy protects against long-term disability accrual in relapsing-remitting MS. In: 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, England, (120-122). Sep 14-17, 2016.

  • Jokubaitis, V. G., Spelman, T., Kalincik, T., Travaglini, D., Paolicelli, D., Duquette, P., Girard, M., Prat, A., Havrdova, E., Horakova, D., Izquierdo, G., Grammond, P., Pucci, E., Grand'Maison, F., Bergamaschi, R., Granella, F., Van Pesch, V., Hupperts, R., Iuliano, G., Spitaleri, D., Sola, P., Boz, C., Fernandez-Bolanos, R., Petersen, T., Verheul, F., Olascoaga, J., McCombe, P., Rozsa, C., Lechner-Scott, J., Terzi, M., Hodgkinson, S., Ramo, C., Saladino, M. L., Butzkueven, H., Lugaresi, A. and Trojano, M. (2015). 10-year progression predictors after first treatment initiation in a relapsing-remitting MS cohort. In: 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona Spain, (100-102). Oct 07-10, 2015.

  • Lorscheider, J., Buzzard, K., Jokubaitis, V., Spelman, T., Havrdova, E., Horakova, D., Trojano, M., Izquierdo, G., Girard, M., Duquette, P., Prat, A., Lugaresi, A., Grand'Maison, F., Grammond, P., Hupperts, R., Alroughani, R., Sola, P., Boz, C., Terzi, M., Pucci, E., Lechner-Scott, J., Bergamaschi, R., Oreja-Guevara, C., Iuliano, G., Van Pesch, V., Bolanos, R. Fernandez, Granella, F., Rio, M. E., Ramo, C., Spitaleri, D. L., Petersen, T., Slee, M., Verheul, F., Ampapa, R., Amato, M. P., McCombe, P., Vucic, S., Sanchez Menoyo, J. L., Cristiano, E., Barnett, M., Hodgkinson, S., Cabrera-Gomez, J. A., Olascoaga, J., Saladino, M. L., Flechter, S., Gray, O., Deri, N., Butzkueven, H. and Kalincik, T. (2015). Defining secondary progressive multiple sclerosis. In: 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona Spain, (798-800). Oct 07-10, 2015.

  • Stewart, T., Jokubaitis, V., Spelman, T., Havrdova, E., Horakova, D., Trojano, M., Izquierdo, G., Girard, M., Duquette, P., Prat, A., Lugaresi, A., Grammond, P., Grand'Maison, F., Sola, P., Hupperts, R., Petersen, T., Pucci, E., Bergamaschi, R., Boz, C., Oreja-Guevara, C., Lechner-Scott, J., Alroughani, R., Ramo, C., Van Pesch, V., Fernandez-Bolanos, R., Iuliano, G., Rio, M. E., Granella, F., Slee, M., Verheul, F., Spitaleri, D. L. A., Amato, M. P., Hodgkinson, S., McCombe, P., Cabrera-Gomez, J. A., Barnett, M., Flechter, S., Olascoaga, J., Vucic, S., Sanchez-Menoyo, J. L., Cristiano, E., Saladino, M. L., Moore, F., Gray, O., Shuey, N., Rozsa, C., Singhal, B., Shaw, C., Butzkueven, H. and Kalincik, T. (2015). Effect of relapse phenotype on the accumulation of disability in relapsing-remitting multiple sclerosis. In: 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona Spain, (726-728). Oct 07-10, 2015.

  • Achiron, A., Chambers, C., Fox, E. J., Mc Combe, P., Otero, S., Margolin, D. H., Kasten, L. and Compston, D. A. S. (2015). Pregnancy outcomes in patients with active RRMS who received alemtuzumab in the clinical development program. In: Multiple Sclerosis Journal. 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona Spain, (581-582). Oct 07-10, 2015.

  • Kalincik, Tomas, Stewart, Tamasine, Jokubaitis, Vilija, Spelman, Tim, Lechner-Scott, Jeannette, Slee, Mark, Hodgkinson, Suzanne, McCombe, Pamela, Barnett, Michael, Vucic, Steve, Shuey, Neil, Shaw, Cameron and Butzkueven, Helmut (2015). Contribution of various relapse phenotypes to disability in multiple sclerosis. In: MS Research Australia Progress in MS Research Conference, Melbourne, Australia, (13-13). Oct 29-30, 2015. doi:10.1177/1352458515616527

  • Jokubaitis, Vilija, Spelman, Tim, Kalincik, Tomask, Lorscheider, Johannes, McCombe, Pamela, Lechner-Scott, Jeannette, Hodgkinson, Suzanne and Butzkueven, Helmut (2015). First-line injectable therapy and pregnancy protect against long-term disability accrual in patients with relapse-onset multiple sclerosis. In: MS Research Australia Progress in MS Research Conference, Melbourne, Australia, (15-15). Oct 29-30, 2015. doi:10.1177/1352458515616527

  • Mantovani, S., Gordon, R., Ngo, S., Pfluger, C., O'Sullivan, J., Noakes, P., Henderson, R., McCombe, P. and Woodruff, T. (2015). Peripheral immune complement activation in neurodegenerative disease. In: 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (124-124). 23-27 August 2015. doi:10.1111/jnc.13188

  • McCombe, P., Achiron, A., Brinar, V., Margolin, D. H., Palmer, J., Oyuela, P. and Compston, D. A. S. (2015). Pregnancy outcomes in the alemtuzumab MS clinical development program. In: Pactrims Invited Lecture, Unknown, (821-822). Unknown. doi:10.1177/1352458514563659

  • Pow, D., Lee, A., Klinkradt, S., Balcar, V. and McCombe, P. (2015). The missing brain glutamate transporters: what we missed and how this changes our understanding of the excitable brain. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia Conference, (76-76). 23-27 August 2015. doi:10.1111/jnc.13185

  • Yan, Jun, Greer, Judith, Mccombe, Pamela, Pender, Michael and Consortium, Anzgene (2014). Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis. In: 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, (53-54). Nov 09-13, 2014. doi:10.1016/j.jneuroim.2014.08.141

  • Inglis, H., Greer, J. and McCombe, P. (2012). Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy. In: Multiple Sclerosis Journal. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Lyon France, (101-102). Oct 10-13, 2012.

  • Inglis, H., Narayanan, R., Wallace, R., Greer, J. and McCombe, P. (2012). Changes in the gene expression and splicing in the CNS during pregnancy and post-partum in the rat. In: Progress in MS Research Conference, Melbourne, Australia, 2011 Conference Abstracts. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, (701-701). 26-28 October 2011. doi:10.1177/1352458512440395

  • McCombe, Pamela, Liu, Jia, Yan, Jun and Greer, Judith (2012). Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke. In: Proceedings of the 11th International Congress of Neuroimmunology (ISNI). 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, (106-106). 4-8 November 2012.

  • Yan, J., Pender, M.P., Liu, J., McCombe, P.A., Greer, J.M. and ANZgene Consortium (2012). Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis. In: Progress in MS Research Conference, Melbourne, Australia, 2011 Conference Abstracts. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, (696-696). 26-28 October 2011. doi:10.1177/1352458512440394

  • McCombe, Pamela A., Baumann, Fusun, Henderson, Robert and Anthony, Pettitt (2011). Bayesian Statistical Motor Unit Number Estimation in the Assessment of ALS. In: 63rd Annual Meeting of the American-Academy-of-Neurology, Honolulu, HI, U.S.A., (A410-A410). APR 09-16, 2011.

  • McCombe, P, Ngo, S, Bellingham, M, Pettitt, A and Henderson, R (2011). Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method. In: Neurology. 63rd AAN Annual Meeting, Honolulu Hi, (A410-A410). Apr 09-16, 2011.

  • McCombe, Pamela, Ngo, Shuyan, Bellingham, Mark, Pettitt, Anthony and Henderson, Robert (2011). Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method. In: 63rd Annual Meeting of the American-Academy-of-Neurology, Honolulu, HI, U.S.A., (A410-A410). APR 09-16, 2011.

  • Ngo, S. T., Bellingham, M. C., Pettitt, A. N., Ridall, P. G., Henderson, R. D. and McCombe, P. A. (2011). Comparison of motor unit number estimation by Bayesian statistical MUNE with histological counting of motor unit numbers. In: 22nd International ALS/MND Symposium, Sydney, Australia, (A410-A410). 30 November - 2 December 2011.

  • Ngo, S. T., Baumann, F., Pettitt, A. N., Ridall, P. G., Henderson, R. D., McCombe, P. A. and Bellingham, M. C. (2011). Estimation of Motor Unit Loss in Amyotrophic Lateral Sclerosis (ALS). In: Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand, (). 31 January -3 February 2011.

  • Steyn, F.J., Ngo, S.T., Buckley, A.J., Leong, J.W., Veldhuis, J.D., McCombe, P.A., Chen, C. and Bellingham, M.C. (2011). Pulsatile Growth Hormone Secretion in the SOD1G93A Mouse Model of ALS. In: Endocrine Society of Australia Annual Scientific Meeting, Perth Convention and Exhibition Centre, Perth, Western Australia, (). 28-31 August.

  • Ngo, S. T., Steyn, F. J., Buckley, A. J., Leong, J. W., Veldhuis, J. D., Chen, C., McCombe, P. A. and Bellingham, M. C. (2011). Pulsatile growth hormone secretion in the SOD1G93A mouse model of ALS resembles growth hormone deficiency in ALS patients. In: 22nd International ALS/MND Symposium, Sydney, Australia, (). 30 November - 2 December 2011.

  • Ngo, S.T., Bellingham, M.C., Baumann, F., Pettitt, A.N., Ridall, P.G., Henderson, R.D. and McCombe, P.A. (2010). Bayesian Motor Unit Number Estimation in the SOD1G93A mouse. In: Forum of European Neuroscience, AMSTERDAM NETHERLANDS, (). 3/7/2010-7/7/2010.

  • Ridall, P. G., Pettitt, A. N., McCombe, P. A. and Henderson, R. D. (2009). Bayesian analysis of the stimulus-response curve. In: Motor unit number estimation (MUNE) and quantitative EMG : selected presentations from the Second International Symposium on MUNE and QEMG. 2nd International Symposium on MUNE and QEMG, Utah, United States, (47-56). 18-20 August 2006. doi:10.1016/S1567-424X(08)00004-4

  • McCombe, P. A., Henderson, R. D., Ridall, P. G. and Pettitt, A. N. (2009). Biological basis for motor unit number estimation through Bayesian statistical analysis of the stimulus-response curve. In: Motor unit number estimation (MUNE) and quantitative EMG : selected presentations from the Second International Symposium on MUNE and QEMG. 2nd International Symposium on MUNE and QEMG, Utah, United States, (39-45). 18-20 August 2006. doi:10.1016/S1567-424X(08)00003-2

  • Henderson, R. D., Ridall, P. G., Pettitt, A. N. and McCombe, P. A. (2009). Results of Bayesian statistical analysis in normal and ALS subjects. In: Motor unit number estimation (MUNE) and quantitative EMG : selected presentations from the Second International Symposium on MUNE and QEMG. 2nd International Symposium on MUNE and QEMG, Utah, United States, (57-63). 18-20 August 2006. doi:10.1016/S1567-424X(08)00005-6

  • Yan, J., Greer, J. M., Cavanagh, H., Henderson, R., O'Sullivan, J., Read, S., Etherington, K. and McCombe, P. A. (2007). Increased population of activated T cells in patients after acute ischemic stroke. In: 37th Annual Scientific Meeting of the Australasian Society for Immunology, Sydney, Australia, (). 2-6 December 2007.

  • McCombe, P. A., Csurhes, P. A., Alizart, M. A. and Greer, J. M. (2005). HLA-DR2 is associated with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in females, but not males. In: Clinical Immunology. FOCIS 2005 Abstract Supplement - 5th Annual Meeting. 5th Annual Meeting of the Federation-of-Clinical-Immunology-Society, Boston, MA, U.S.A., (S90-S91). 12-16 May 2005.

  • McCombe, P. A., Sullivan, A. A. and Alizart, M. A. (2002). Antibodies to PMP-22 peptides in inflammatory neuropathy. In: 10th International Congress on Neuromuscular Diseases, Vancouver BC, Canada, (S115-S115). 7-12 July 2002.

  • Pender, M. P., Csurhes, P. A., Wolfe, N. P., Cameron, K. D., McCombe, P. A., Greer, J. M. and Good, M. F. (2002). Blood T-cell reactivity to gangliosides GM3 and GQ1b is increased in patients with primary progressive multiple sclerosis. In: 127th Annual Meeting of the American Neurological Association, New York City, NY, USA, (S71-S72). October 12-16 2002.

  • McCombe, P. A., Morton, J. and Saines, N. (2002). Multifocal motor neuropathy: Improvement after autologous bone marrow transplantation. In: 10th International Congress on Neuromuscular Diseases, Vancouver Canada, (S14-S15). 7-12 July 2002. doi:10.1016/S0022-510X(02)80013-2

  • McCombe, P. A., Sullivan, A. A., Alizart, M. A., Csurhes, P. A., Greer, J. M. and Pender, M. P. (2002). T cell responses to gangliosides in patients with inflammatory neuropathy. In: Abstracts of the Xth International Congress on Neuromuscular Diseases. Xth International Congress on Neuromuscular Diseases, Vancouver, Canada, (S115-S115). 07-12 Jul 2002. doi:10.1016/S0022-510X(02)80069-7

  • Pender, M. P., Csurhes, P. A., Greer, J. M., Mowat, P. D., Henderson, R. D., Cameron, K. D., McCombe, P. A. and Good, M. F. (1999). Fluctuations in the frequencies of circulating myelin-reactive T cells in healthy subjects and patients with multiple sclerosis. In: 15th Congress of the European Com. for Treatment & Research in Multiple Sclerosis 4th Annual Meeting of America's Com. for Treatment & Research in Multiple Sclerosis. ECTRIMS/ACTRIMS'99, Basel, Switzerland, (S60). 15 - 18 Sept, 1999.

  • Sullivan, A., Csurhes, P. A., Alizart, M., Pender, M. P. and McCombe, P. A. (1999). The role of PMP-22 as an autoantigen in GBS and CIDP. In: Royal Brisbane Hospital Health Care Symposium. Royal Brisbane Hospital Health Care Symposium, Westpac Auditorium Bancroft Cen., (79). 21 - 27 Oct, 1999.

  • Cameron, K. D., Csurhes, P. A., Good, M. F., Greer, J. M., Henderson, R. D., McCombe, P. A., Mowat, P. D. and Pender, M. P. (1998). The frequency of circulating T cells reactive to PLP184-209 increases prior to MS relapse and development of new MR1 lesions. In: Fifth International Congress of the International Society of Neuroimmunology, Montreal, Canada, (76-76). August 23-27, 1998. doi:10.1016/S0165-5728(98)91636-8

  • McCombe, P. A., Nickson, I. and Pender, M. P. (1997). Cytokine mRNA expression in lymphocytes from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. In: -, -, (1364-1364). -. doi:10.1111/j.1750-3639.1997.tb01051.x

  • McCombe, P. A., Harness, J., Cavanagh, A. C. and Morton, H. (1997). Early pregnancy factor and experimental autoimmune encephalomyelitis. In: American Neurological Association Annual Meeting, San Diego CA, United States, (423-423). 28 September - 1 October 1997.

  • Pender, M. P., White, C. A. and McCombe, P. A. (1996). Decreased expression of the apoptosis inhibitor Bcl-2 in T cells in the central nervous system in experimental autoimmune encephalomyelitis. In: American Neurological Association Annual Meeting, Miami FL, United States, (552-552). 13-16 October 1996. doi:10.1002/ana.410400326

  • Pender, M. P., Greer, J. M., Csurhes, P. A., Cameron, K. D., McCombe, P. A. and Good, M. F. (1996). T-cell reactivity to peptides of proteolipid protein and myelin basic protein in multiple sclerosis. In: 121st Annual Meeting of the American Neurological Association, Miami, FL, U.S.A., (552-552). 13-16 October 1996. doi:10.1002/ana.410400326

  • Cameron, K., Csurhes, P., Greer, J., McCombe, P. and Pender, M. (1995). Reactivity to myelin proteolipid protein in multiple sclerosis patients. In: 9th International Congress of Immunology. The 9th International Congress of Immunology, San Francisco, California, USA, (626-626). 23-29 July 1995.

  • McCombe, P. A., Dejersey, J. and Pender, M. P. (1993). Chronic relapsing experimental autoimmune encephalomyelitis: Studies of cells from the spinal cord. In: Joint Meeting of the Australasian Society for Immunology and Society for Leukocyte Biology, Sydney, NSW, Australia, (124-124). 1-5 December 1993.

  • Tabi, Z., McCombe, P. A. and Pender, M. P. (1993). Flow cytometric analysis of apoptotic T cells isolated from the central nervous system in experimental autoimmune encephalomyelitis. In: Joint Meeting of the Australasian Society for Immunology and Society for Leukocyte Biology, Sydney, NSW, Australia, (97-97). 1-5 December 1993.

  • McCombe, P. A., Csurhes, P. A., Houghten, R. A., Good, M. F. and Pender, M. P. (1993). Human T cell responses to myelin basic protein isoforms. In: International Congress on the Regulation of Leukocyte Production and Immune Function held at the Joint Meeting of the Australasian Society for Immunology and Society for Leukocyte Biology, Sydney, New South Wales, Australia, (124-124). 1-5 December 1993.

  • McCombe, P. A., Pollard, J. D. and McLeod, J. G. (1988). Absence of antimyelin antibodies and serum demyelinating factors in most CIDP patients. In: -, -, (465-465). -.

  • Feeney, D. J., Pollard, J. D., Stewart, G. J., Clark, P., McCombe, P., Kirk, R. L. and McLeod, J. G. (1985). Immunogenetics of human demyelinating diseases. In: -, -, (A39-A39). -.

  • McCombe, P. A., Clark, P., Pollard, J. D., Hammond, S. R. and McLeod, J. G. (1984). ALPHA-1 Antitrypsin Phenotypes in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multiple Sclerosis. In: You have full text access to this content 109th Annual Meeting of the American Neurological Association, Baltimore MD, (141-141). 7-10 October 1984. doi:10.1002/ana.410160128

  • McCombe, P., Lavin, M. F., Campbell, B., Mansbridge, J. N. and Kidson, C. (1975). Repair of ultraviolet irradiation damage in mouse neuroblastoma cells: a model for post mitotic cell repair. In: Australian Biochemical Society Annual General Meeting, -, (106-106). -.

Edited Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision