Professor Pamela McCombe


UQ Centre for Clinical Research
Faculty of Medicine

Affiliate Professor

Royal Brisbane Clinical Unit
Faculty of Medicine
+61 7 334 66017



Dr McCombe graduated in Medicine from UQ and completed a Science degree for medical students. She then trained as a neurologist in Sydney, at Prince Henry and Prince of Wales Hospitals. She obtained a PhD from the University of Sydney. She obtained experience in Neurophysiology in Cleveland and then returned to UQ as a post-doctoral fellow. She worked for some years as a research fellow in Neuroimmunology and was an NHMRc SRF. Later she resumed clinical practice as a neurologist, and contimued her research as an NHMRC Practitioner Fellow. She is currentlyProfessor and Head of the Royal Brisbane Clinical school in the School of Medicine and Co-head of the Brain and Mental Health Theme at the UQ Centre for Clinical Research.

Research Interests

  • Biomarkers in ALS
    This is a collaborative project wih Dr Rob Henderson, Prof Tony Pettit and Dr Gareth Ridall- looking at motor unit number estimation in ALS
  • Inflammatory neuropathy
    This is an ongoing study of the immunological basis of acute and chronic inflammatory neuropathy
  • Pregnancy and EAE
    this study will investigate the effects of pregnancy on the clinical course of EAE, an experimental disae that is a model of multiple sclerosis
  • Immunology of stroke
    This study involves documenting the immune responses after human stroke and determining the significance of these responses.


  • PhD, The University of Sydney
  • BSc, The University of Queensland
  • MBBS, The University of Queensland


  • Bukhari, Wajih, Prain, Kerri M., Waters, Patrick, Woodhall, Mark, O'Gorman, Cullen M., Clarke, Laura, Silvestrini, Roger A., Bundell, Christine S., Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brown, Matthew, Brownlee, Wallace J., Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Dear, Keith, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P. D., Heshmat, Saman, Hodgkinson, Suzanne, Jimenez-Sanchez, Sofia, Killpatrick, Trevor, King, John, Kneebone, Christopher, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming-Wei, Lynch, Christpher, Macdonell, Richard, Mason, Deborah F., McCombe, Pamela A., Pender, Michael P., Pereira, Jennifer A., Pollard, John D., Reddel, Stephen W., Shaw, Cameron, Spies, Judith, Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G., Marriott, Mark P., Parratt, John D. E., Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Wilson, Robert J., Vincent, Angela and Broadley, Simon A. (2017) Incidence and prevalence of NMOSD in Australia and New Zealand. Journal of Neurology Neurosurgery and Psychiatry, 88 8: 632-638. doi:10.1136/jnnp-2016-314839

  • Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017) Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 4: 418-428. doi:10.1002/mgg3.302

  • McCombe, P. A., Wray, N. R. and Henderson, R. D. (2017) Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity. Expert Review of Neurotherapeutics, 17 6: 561-577. doi:10.1080/14737175.2017.1273772

View all Publications


  • (2017) Master Philosophy

  • (2017) Doctor Philosophy

  • Doctor Philosophy

View all Supervision


Book Chapter

  • Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. In Ronald Ross Watson and Victor R. Preedy (Ed.), Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy (pp. 355-361) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-411462-3.00036-9

  • McCombe, Pamela A. and Greer, Judith M. (2014). Sexual dimorphism in the immune system. In Ian R. Mackay and Noel R. Rose (Ed.), The Autoimmune Diseases 5th ed. (pp. 319-328) San Diego, United States: Academic Press. doi:10.1016/B978-0-12-384929-8.00024-1

Journal Article

Conference Publication

Edited Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision