The University of Queensland

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018) Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 2: 112-122. doi:10.1089/scd.2017.0224

The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials

Whitworth, Deanne J. and Pask, Andrew J. (2016) The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials. Seminars in Cell and Developmental Biology, 56 117-121. doi:10.1016/j.semcdb.2016.01.006

Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment

Burkard, Michael, Whitworth, Deanne, Schirmer, Kristin and Nash, Susan B. (2015) Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment. Aquatic Toxicology, 167 240-247. doi:10.1016/j.aquatox.2015.08.005

Stem cell therapies for treating osteoarthritis: prescient or premature?

Whitworth, Deanne J. and Banks, Tania A. (2014) Stem cell therapies for treating osteoarthritis: prescient or premature?. The Veterinary Journal, 202 3: 416-424. doi:10.1016/j.tvjl.2014.09.024

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 2: 251-261. doi:10.1016/j.scr.2014.05.006

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print . doi:10.1089/scd.2013.0634

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014) Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles 13: 1-9. doi:10.1089/scd.2013.0461

Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012) Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 12: 2288-2297. doi:10.1089/scd.2011.0608

The transgenic mouse in studies of mammalian sexual differentiation.

Whitworth, Deanne J. and Behringer, Richard R. (2001). The transgenic mouse in studies of mammalian sexual differentiation.. In Martin M. Matzuk, Chester W. Brown, T. Rajendra Kumar and P. Michael Conn (Ed.), Transgenics in Endocrinology (pp. 19-39) Totowa, NJ, U.S.A.: Humana Press.

Sexual determination and differentiation in the marsupial Macropus eugenii

Shaw, Geoffrey, Harry, Jenny L., Whitworth, Deanne J. and Renfree, Marilyn B. (1997). Sexual determination and differentiation in the marsupial Macropus eugenii. In N. R. Saunders and L. A. Hinds (Ed.), Marsupial biology : Recent research, new perspectives (pp. 132-141) Sydney, NSW, Australia: University of NSW Press.

Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases

Fortuna, Patrick R. J., Bielefeldt-Ohmann, Helle, Ovchinnikov, Dmitry A., Wolvetang, Ernst Jurgen and Whitworth, Deanne Jeanette (2018) Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases. Stem cells and development, . doi:10.1089/scd.2017.0106

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018) Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 2: 112-122. doi:10.1089/scd.2017.0224

The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials

Whitworth, Deanne J. and Pask, Andrew J. (2016) The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials. Seminars in Cell and Developmental Biology, 56 117-121. doi:10.1016/j.semcdb.2016.01.006

Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment

Burkard, Michael, Whitworth, Deanne, Schirmer, Kristin and Nash, Susan B. (2015) Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment. Aquatic Toxicology, 167 240-247. doi:10.1016/j.aquatox.2015.08.005

Stem cell therapies for treating osteoarthritis: prescient or premature?

Whitworth, Deanne J. and Banks, Tania A. (2014) Stem cell therapies for treating osteoarthritis: prescient or premature?. The Veterinary Journal, 202 3: 416-424. doi:10.1016/j.tvjl.2014.09.024

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 2: 251-261. doi:10.1016/j.scr.2014.05.006

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014) Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print . doi:10.1089/scd.2013.0634

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014) Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles 13: 1-9. doi:10.1089/scd.2013.0461

Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012) Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 12: 2288-2297. doi:10.1089/scd.2011.0608

Overtraining syndrome in horses

McGowan, C. M. and Whitworth, D. J. (2008) Overtraining syndrome in horses. Comparative Exercise Physiology, 5 2: 57-65. doi:10.1017/S1478061508979202

Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression

Pask, Andrew J., Whitworth, Deanne, J., Mao Chai-An, Wei, Kei-Jun, Sankovic, Natasha, Graves, Jennifer A. M., Shaw, Geoffrey, Renfree, Marilyn B. and Behringer, Richard R. (2004) Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression. Biology of Reproduction, 70 1: 160-167. doi:10.1095/biolreprod.103.020016

Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial

Whitworth, D. J., Pask, A. J., Shaw, G., Marshall Graves, J. A., Behringer, R. R. and Renfree, M. B. (2001) Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial. Gene, 277 1-2: 209-219. doi:10.1016/S0378-1119(01)00677-1

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

Bi, Weimin, Huang, Wendong, Whitworth, Deanne J., Deng, Jian Min, Zhang, Zhaoping, Behringer, Richard R. and de Crombrugghe, Benoit (2001) Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proceedings of the National Academy of Sciences of the United States of America, 98 12: 6698-6703. doi:10.1073/pnas.111092198

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse

Bishop, Colin E., Whitworth, Deanne J., Qin, Yanjun, Agoulnik, Alexander I., Agoulnik, Irina A., Harrison, Wilbur R., Behringer, Richard R. and Overbeek, Paul A. (2000) A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nature Genetics, 26 4: 490-494. doi:10.1038/82652

Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta

Whitworth, Deanne J., Hunt, Leigh and Licht, Paul (2000) Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta. General and Comparative Endocrinology, 118 2: 354-358.

High specificity of Müllerian-inhibiting substance signaling in vivo

Mishina, Y., Whitworth, D. J., Racine, C. and Behringer, R. R.. (1999) High specificity of Müllerian-inhibiting substance signaling in vivo. Endocrinology, 140 5: 2084-2088. doi:10.1210/en.140.5.2084

Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea

Whitworth, Deanne J., Licht, Paul, Racey, Paul A. and Glickman, Stephen E. (1999) Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea. Biology of Reproduction, 60 2: 413-418. doi:10.1095/biolreprod60.2.413

XX germ cells: The difference between an ovary and a testis

Whitworth, Deanne J. (1998) XX germ cells: The difference between an ovary and a testis. Trends in Endocrinology and Metabolism, 9 1: 2-6. doi:10.1016/S1043-2760(98)00002-2

Müllerian duct regression in a marsupial, the tammar wallaby

Whitworth, Deanne J., Shaw, Geoffrey and Renfree Marilyn B. (1997) Müllerian duct regression in a marsupial, the tammar wallaby. Anatomy And Embryology, 196 1: 39-46. doi:10.1007/s004290050078

Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro

Whitworth, Deanne J., Shaw, Geoffrey and Renfree, Marilyn B. (1996) Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro. Development (Cambridge), 122 12: 4057-4063.

IMMUNOMODULATORY AND ANTI-INFLAMMATORY CAPABILITIES OF CANINE MESENCHYMAL STEM CELLS AND THEIR CLINICAL POTENTIAL

Shahsavari, A., Ovchinnikov, D., Wolvetang, E. and Whitworth, D. (2018). IMMUNOMODULATORY AND ANTI-INFLAMMATORY CAPABILITIES OF CANINE MESENCHYMAL STEM CELLS AND THEIR CLINICAL POTENTIAL. In: Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney Australia, (). May 24-26, 2017.

INDUCED PLURIPOTENT STEM CELLS FROM A MARSUPIAL, THE TASMANIAN DEVIL (SARCOPHILUS HARRISII): INSIGHT INTO THE EVOLUTION OF MAMMALIAN PLURIPOTENCY

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry, Wolvetang, Ernst and Whitworth, Deanne (2018). INDUCED PLURIPOTENT STEM CELLS FROM A MARSUPIAL, THE TASMANIAN DEVIL (SARCOPHILUS HARRISII): INSIGHT INTO THE EVOLUTION OF MAMMALIAN PLURIPOTENCY. In: Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney Australia, (). May 24-26, 2017.

Platypus Induced Pluripotent Stem Cells Reveal that Acquisition of SOX2 Responsiveness Facilitated Expansion of the Pluripotency Network During Mammalian Evolution

Whitworth, D. J., Gauthier, M.-E., Ovchinnikov, D. A., Grimmond, S. M., Marshall Graves, J. A. and Wolvetang, E. J. (2015). Platypus Induced Pluripotent Stem Cells Reveal that Acquisition of SOX2 Responsiveness Facilitated Expansion of the Pluripotency Network During Mammalian Evolution. In: Annual Meeting of the International Society for Stem Cell Research, Stockholm , Sweden, (). 24-27 June 2015.

Stem cell therapies for treating osteoarthritis: prescient or premature?

Whitworth, Deanne (2015). Stem cell therapies for treating osteoarthritis: prescient or premature?. In: Australian and New Zealand College of Veterinary Scientists College Science Week Conference, Gold Coast, QLD, Australia, (). 9-11 July 2015.

FGF/ERK signalling induces X chromosome inactivation in LIF-dependent equine induced pluripotent stem cells

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2013). FGF/ERK signalling induces X chromosome inactivation in LIF-dependent equine induced pluripotent stem cells. In: ASSCR 2013: 6th Annual Meeting for Australasian Society for Stem Cell Research, South Bank, QLD, Australia, (). 27-29 October, 2013.

The generation of induced pluripotent stem cells from human CD34+ cells reveals a sex bias in reprogramming efficiency

Whitworth, D. J., Sun, J and Wolvetang, E. J. (2012). The generation of induced pluripotent stem cells from human CD34+ cells reveals a sex bias in reprogramming efficiency. In: Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan, (). 13-16 June 2012.

Sox9 and Sertoli cell differentiation in the mouse

Whitworth, D. J., Bi, W., Deng, J. M., de Crombrugghe, B. and Behringer, R. R. (2000). Sox9 and Sertoli cell differentiation in the mouse. In: Proceedings of the Second International Symposium on the Biology of Vertebrate Sex Determination. Second International Symposium on the Biology of Vertebrate Sex Determination, Hawaii, U.S.A., (87). xx.

An analysis of the behaviour of Sox9 mutant cells in testicular development

Whitworth, D. J., Bi, W., Deng, J. M., de Crombrugghe, B. and Behringer, R. R. (1998). An analysis of the behaviour of Sox9 mutant cells in testicular development. In: Proceedings of the Cold Spring Harbor Meeting on Mouse Molecular Genetics. Cold Spring Harbor Meeting on Mouse Molecular Genetics, Cold Spring Harbor Laboratory, New York, (288). xx.

Testis-like steroidogenesis in the ovotestis of the European mole

Whitworth, Deanne, Licht, .P, Racey, P. A. and Glickman, S. E. (1998). Testis-like steroidogenesis in the ovotestis of the European mole. In: Society for the Study of Reproduction, Ann Arbor, MI, (213-213). xx.

Sexual differentiation in marsupial mammals

Renfree, Marilyn B., Shaw, Geoffrey, Harry, Jenny L. and Whitworth, Deanne J. (1995). Sexual differentiation in marsupial mammals. In: Keystone Symposia on Molecular & Cellullar Biology. Keystone Symposium on the Molecular Basis for the Differences Between the Sexes, Tamarron, CO, U.S.A., (41-41). 12-18 February 1995.

Gonadal sex reversal in female tammar wallabies is induced by MIS

Whitworth, D. J. and Renfree, M. B. (1994). Gonadal sex reversal in female tammar wallabies is induced by MIS. In: Proceedings of the 23th Annual Conference of the Australian Society for Reproductive Biology. Australian Society for Reproductive Biology and the Endocrine Society of Australia Annual Scientific Meeting, Sydney, NSW, Australia, (100). 30 September-2 October 1991.

Müllerian inhibiting substance gene expression in the developing gonad of the tammar wallaby (Macropus eugenii)

Whitworth, D. J., Harry, J. L., Shaw, G. and Renfree, M. B. (1994). Müllerian inhibiting substance gene expression in the developing gonad of the tammar wallaby (Macropus eugenii). In: Society for the Study of Reproduction and Fertility, Southhampton, UK, (52-52). xx.

Müllerian inhibiting substance gene expression in the developing testis of the tammar wallaby (Macropus eugenii)

Whitworth, Deanne, Harry, J. L., Shaw, G. and Renfree, M. B. (1994). Müllerian inhibiting substance gene expression in the developing testis of the tammar wallaby (Macropus eugenii). In: Proceedings of the Australian Society for Reproductive Biology. Australian Society for Reproductive Biology, Sydney , Australia, (68). xx.

Density of adrenergic nerves about guinea-pig intrapulmonary arterial smooth muscle increases with decreasing vessel diameter

Whitworth, D. J. and McLean, J. R. (1992). Density of adrenergic nerves about guinea-pig intrapulmonary arterial smooth muscle increases with decreasing vessel diameter. In: Communications of the Fifty-fifth Meeting of the Society at the University of Melbourne. The 55th Meeting of the Australian Physiological and Pharmacological Society jointly with the Australian and New Zealand Society of Neplanology, Melbourne, VIC, Australia, (78-78). 27-28 February 1992.