The University of Queensland

How to stimulate and facilitate early stage antibiotic discovery

Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163

Metal complexes as a promising source for new antibiotics

Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

Stone, M. Rhia L., Masi, Muriel, Phetsang, Wanida, Pagès, Jean-Marie, Cooper, Matthew A. and Blaskovich, Mark A. T. (2019). Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux. MedChemComm, 10 (6), 901-906. doi: 10.1039/c9md00124g

The diminished antimicrobial pipeline

Blaskovich, Mark A.T. (2019). The diminished antimicrobial pipeline. Microbiology Australia, 40 (2), 92-96. doi: 10.1071/MA19025

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018). Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 (6), 485-499. doi: 10.1080/14787210.2018.1483240

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

Stone, M Rhia L., Butler, Mark S., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2018). Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance. Trends in Biotechnology, 36 (5), 523-536. doi: 10.1016/j.tibtech.2018.01.004

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w

Unusual amino acids in medicinal chemistry

Blaskovich, Mark A. T. (2016). Unusual amino acids in medicinal chemistry. Journal of Medicinal Chemistry, 59 (24), 10807-10836. doi: 10.1021/acs.jmedchem.6b00319

Antibiotics in the clinical pipeline at the end of 2015

Butler, Mark S., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Antibiotics in the clinical pipeline at the end of 2015. The Journal of Antibiotics, 70 (1), 1-22. doi: 10.1038/ja.2016.72

Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli

Phetsang, Wanida, Pelingon, Ruby, Butler, Mark S., KC, Sanjaya, Pitt, Miranda, Kaeslin, Geraldine, Cooper, Matthew A. and Blaskovich, Mark A. T. (2016). Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli. ACS Infectious Diseases, 2 (10), 688-701. doi: 10.1021/acsinfecdis.6b00080

Handbook on syntheses of amino acids : General routes for the syntheses of amino acids

Blaskovich, Mark A (2010). Handbook on syntheses of amino acids : General routes for the syntheses of amino acids. First ed. New York , NY, U.S.A.: Oxford University Press; American Chemical Society.

Handbook on syntheses of amino acids : General routes for the syntheses of amino acids

Blaskovich, Mark A (2010). Handbook on syntheses of amino acids : General routes for the syntheses of amino acids. First ed. New York , NY, U.S.A.: Oxford University Press; American Chemical Society.

Biodegradation of Petrochemical Refinery Wastewater

Jain, Marut, Noor, Aisha, Sahoo, Abhisek, Pant, Kamal K., Ziora, Zyta M. and Blaskovich, Mark A. T. (2024). Biodegradation of Petrochemical Refinery Wastewater. Biodegradation of Toxic and Hazardous Chemicals. (pp. 1-13) Boca Raton: CRC Press. doi: 10.1201/9781003391487-1

Application of antibiotic-derived fluorescent probes to bacterial studies

Zhang, Bing, Stone, M. Rhia L., Kc, Sanjaya, Łapińska, Urszula, Pagliara, Stefano and Blaskovich, Mark A.T. (2022). Application of antibiotic-derived fluorescent probes to bacterial studies. Methods in enzymology. (pp. 1-28) edited by Erin E. Carlson. San Diego, CA, United States: Academic Press. doi: 10.1016/bs.mie.2021.11.010

Solid-phase synthesis of octapeptin lipopeptides

Hansford, Karl A., Ziora, Zyta M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Solid-phase synthesis of octapeptin lipopeptides. Peptide synthesis: methods and protocols. (pp. 199-213) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0227-0_13

Photocatalytic degradation of parabens: A comprehensive meta-analysis investigating the environmental remediation potential of emerging pollutant

Khan, Sadaf Aiman, Jain, Marut, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A.T. (2024). Photocatalytic degradation of parabens: A comprehensive meta-analysis investigating the environmental remediation potential of emerging pollutant. Science of The Total Environment, 920 171020, 171020. doi: 10.1016/j.scitotenv.2024.171020

Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration

Jin, Wanli, Stehbens, Samantha J, Barnard, Ross T, Blaskovich, Mark A T and Ziora, Zyta M (2023). Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration. Journal of Pharmacy and Pharmacology, 76 (1), 13-22. doi: 10.1093/jpp/rgad107

Bugs in floods

Blaskovich, Mark A. T. and Harris, Patrick N. A. (2023). Bugs in floods. Microbiology Australia, 44 (4), 176-180. doi: 10.1071/ma23051

A supramolecular self-assembly of peptide-derived compounds via 1,5-disubstituted tetrazole-based supramolecular synthons: An experimental and computational study

Bojarska, Joanna, Breza, Martin, Remko, Milan, Yuan, Ye, Ziora, Zyta M., Chai, Tsun-Thai, Madura, Izabela D., Kaczmarek, Krzysztof, Blaskovich, Mark A.T. and Wolf, Wojciech M. (2023). A supramolecular self-assembly of peptide-derived compounds via 1,5-disubstituted tetrazole-based supramolecular synthons: An experimental and computational study. Journal of Molecular Structure, 1288 135732. doi: 10.1016/j.molstruc.2023.135732

Impact of the new membrane-targeting lipoglycopeptide antibiotic MCC5145 on the treatment of bacteremic pneumococcal pneumonia in mice

Ogunniyi, Abiodun D., Nguyen, Hang Thi, Hansford, Karl A., Cooper, Matthew A., Trott, Darren J. and Blaskovich, Mark A. T. (2023). Impact of the new membrane-targeting lipoglycopeptide antibiotic MCC5145 on the treatment of bacteremic pneumococcal pneumonia in mice. Microbiology Spectrum, 11 (5) e04459-22, 1-6. doi: 10.1128/spectrum.04459-22

The antimicrobial properties of Pd(II)‐ and Ru(II)‐pyta complexes

van Niekerk, Annick, Joseph, M. Cassiem, Kavanagh, Angela, Dinh, Hue, Swarts, Andrew J., Mapolie, Selwyn F., Zuegg, Johannes, Cain, Amy K., Elliott, Alysha G., Blaskovich, Mark A. T. and Frei, Angelo (2023). The antimicrobial properties of Pd(II)‐ and Ru(II)‐pyta complexes. ChemBioChem, 24 (19) e202300247, e202300247. doi: 10.1002/cbic.202300247

Natural products as anthelmintics: safeguarding animal health

Salim, Angela A., Butler, Mark S., Blaskovich, Mark A. T., Henderson, Ian R. and Capon, Robert J. (2023). Natural products as anthelmintics: safeguarding animal health. Natural Product Reports, 40 (11), 1754-1808. doi: 10.1039/d3np00019b

Quantifying the economic and clinical value of reducing antimicrobial resistance in gram-negative pathogens causing hospital-acquired infections in Australia

Gordon, Jason P., Al Taie, Amer, Miller, Ryan L., Dennis, James W., Blaskovich, Mark A. T., Iredell, Jonathan R., Turnidge, John D., Coombs, Geoffrey W., Grolman, David Charles and Youssef, Jacqueline (2023). Quantifying the economic and clinical value of reducing antimicrobial resistance in gram-negative pathogens causing hospital-acquired infections in Australia. Infectious Diseases and Therapy, 12 (7), 1875-1889. doi: 10.1007/s40121-023-00835-9

Antibiotics in the clinical pipeline as of December 2022

Butler, Mark S., Henderson, Ian R., Capon, Robert J. and Blaskovich, Mark A. T. (2023). Antibiotics in the clinical pipeline as of December 2022. The Journal of Antibiotics, 76 (8), 431-473. doi: 10.1038/s41429-023-00629-8

Siderophore conjugates to combat antibiotic-resistant bacteria

Rayner, Beth, Verderosa, Anthony D., Ferro, Vito and Blaskovich, Mark A. T. (2023). Siderophore conjugates to combat antibiotic-resistant bacteria. RSC Medicinal Chemistry, 14 (5), 800-822. doi: 10.1039/d2md00465h

Photocatalytic degradation of methylparaben using green nanosilver supported on reduced graphene oxide

Khan, Sadaf Aiman, Jain, Marut, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A. T. (2023). Photocatalytic degradation of methylparaben using green nanosilver supported on reduced graphene oxide. Industrial and Engineering Chemistry Research, 62 (17), 6646-6659. doi: 10.1021/acs.iecr.3c00146

Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

Zhang, Bing, Phetsang, Wanida, Stone, M. Rhia L., Kc, Sanjaya, Butler, Mark S., Cooper, Matthew A., Elliott, Alysha G., Łapińska, Urszula, Voliotis, Margaritis, Tsaneva-Atanasova, Krasimira, Pagliara, Stefano and Blaskovich, Mark A. T. (2023). Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage. Communications Biology, 6 (1) 409, 1-16. doi: 10.1038/s42003-023-04745-x

Metals to combat antimicrobial resistance

Frei, Angelo, Verderosa, Anthony D., Elliott, Alysha G., Zuegg, Johannes and Blaskovich, Mark A. T. (2023). Metals to combat antimicrobial resistance. Nature Reviews Chemistry, 7 (3), 1-23. doi: 10.1038/s41570-023-00463-4

Use of antiviral agents and other therapies for COVID-19

Blaskovich, Mark A. T. and Verderosa, Anthony D. (2023). Use of antiviral agents and other therapies for COVID-19. Seminars in Respiratory and Critical Care Medicine, 44 (1), 118-129. doi: 10.1055/s-0042-1758837

Correction: Antibiotics in the clinical pipeline as of December 2022 (The Journal of Antibiotics, (2023), 76, 8, (431-473), 10.1038/s41429-023-00629-8)

Butler, Mark S., Henderson, Ian R., Capon, Robert J. and Blaskovich, Mark A. T. (2023). Correction: Antibiotics in the clinical pipeline as of December 2022 (The Journal of Antibiotics, (2023), 76, 8, (431-473), 10.1038/s41429-023-00629-8). Journal of Antibiotics, 77 (1), 71-71. doi: 10.1038/s41429-023-00671-6

A fluorescently labelled quaternary ammonium compound (NBD-DDA) to study resistance mechanisms in bacteria

Nordholt, Niclas, O'Hara, Kate, Resch-Genger, Ute, Blaskovich, Mark A. T., Rühle, Bastian and Schreiber, Frank (2022). A fluorescently labelled quaternary ammonium compound (NBD-DDA) to study resistance mechanisms in bacteria. Frontiers in Microbiology, 13 1023326, 1-13. doi: 10.3389/fmicb.2022.1023326

Leveraging the potential of silver nanoparticles-based materials towards sustainable water treatment

Khan, Sadaf Aiman, Jain, Marut, Pandey, Ashish, Pant, Kamal Kishore, Ziora, Zyta Maria, Blaskovich, Mark A. T., Shetti, Nagaraj P. and Aminabhavi, Tejraj M. (2022). Leveraging the potential of silver nanoparticles-based materials towards sustainable water treatment. Journal of Environmental Management, 319 115675, 115675. doi: 10.1016/j.jenvman.2022.115675

Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments

Frei, Angelo, Elliott, Alysha G., Kan, Alex, Dinh, Hue, Bräse, Stefan, Bruce, Alice E., Bruce, Mitchell R., Chen, Feng, Humaidy, Dhirgam, Jung, Nicole, King, A. Paden, Lye, Peter G., Maliszewska, Hanna K., Mansour, Ahmed M., Matiadis, Dimitris, Muñoz, María Paz, Pai, Tsung-Yu, Pokhrel, Shyam, Sadler, Peter J., Sagnou, Marina, Taylor, Michelle, Wilson, Justin J., Woods, Dean, Zuegg, Johannes, Meyer, Wieland, Cain, Amy K., Cooper, Matthew A. and Blaskovich, Mark A. T. (2022). Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments. JACS Au, 2 (10), 2277-2294. doi: 10.1021/jacsau.2c00308

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

Ang, Chee Wei, Lee, Brendon M., Jackson, Colin J., Wang, Yuehong, Franzblau, Scott G., Francisco, Amanda F., Kelly, John M., Bernhardt, Paul V., Tan, Lendl, West, Nicholas P., Sykes, Melissa L., Hinton, Alexandra O., Bolisetti, Raghu, Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A.T. (2022). Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection. Journal of Medicinal Chemistry, 65 (19), 13125-13142. doi: 10.1021/acs.jmedchem.2c00972

A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381. doi: 10.1126/scitranslmed.abj238

A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381, 1-16. doi: 10.1126/scitranslmed.abj2381

Investigations into the membrane activity of arenicin antimicrobial peptide AA139

Edwards, Ingrid A., Henriques, Sónia T., Blaskovich, Mark A.T., Elliott, Alysha G. and Cooper, Matthew A. (2022). Investigations into the membrane activity of arenicin antimicrobial peptide AA139. Biochimica et Biophysica Acta - General Subjects, 1866 (8) 130156, 130156. doi: 10.1016/j.bbagen.2022.130156

N-Alkyl-2-quinolonopyrones demonstrate antimicrobial activity against ESKAPE pathogens including Staphylococcus aureus

Moynihan, Eoin, Mackey, Katrina, Blaskovich, Mark A. T., Reen, F. Jerry and McGlacken, Gerard (2022). N-Alkyl-2-quinolonopyrones demonstrate antimicrobial activity against ESKAPE pathogens including Staphylococcus aureus. ACS Medicinal Chemistry Letters, 13 (8), 1358-1362. doi: 10.1021/acsmedchemlett.2c00185

Fast bacterial growth reduces antibiotic accumulation and efficacy

Łapińska, Urszula, Voliotis, Margaritis, Lee, Ka Kiu, Campey, Adrian, Stone, Rhia M. L., Tuck, Brandon, Phetsang, Wanida, Zhang, Bing, Tsaneva-Atanasova, Krasimira, Blaskovich, Mark A. T. and Pagliara, Stefano (2022). Fast bacterial growth reduces antibiotic accumulation and efficacy. eLife, 11 e74062, 1-33. doi: 10.7554/ELIFE.74062

Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant escherichia coli sensitivity to previously ineffective antibiotics

Hong, Yaoqin, Qin, Jilong, Verderosa, Anthony D., Hawas, Sophia, Zhang, Bing, Blaskovich, Mark A. T., Cronan, John E. and Totsika, Makrina (2022). Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant escherichia coli sensitivity to previously ineffective antibiotics. mSphere, 7 (3), e0011722. doi: 10.1128/msphere.00117-22

Bridging informatics and medicinal inorganic chemistry: toward a database of metallodrugs and metallodrug candidates

Medina-Franco, José L., López-López, Edgar, Andrade, Emma, Ruiz-Azuara, Lena, Frei, Angelo, Guan, Davy, Zuegg, Johannes and Blaskovich, Mark A.T. (2022). Bridging informatics and medicinal inorganic chemistry: toward a database of metallodrugs and metallodrug candidates. Drug Discovery Today, 27 (5), 1420-1430. doi: 10.1016/j.drudis.2022.02.021

Statistical evaluation of cow-dung derived activated biochar for phenol adsorption: adsorption isotherms, kinetics, and thermodynamic studies

Jain, Marut, Khan, Sadaf Aiman, Sahoo, Abhisek, Dubey, Prashant, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A.T. (2022). Statistical evaluation of cow-dung derived activated biochar for phenol adsorption: adsorption isotherms, kinetics, and thermodynamic studies. Bioresource Technology, 352 127030, 127030. doi: 10.1016/j.biortech.2022.127030

Mechanisms underlying synergistic killing of Polymyxin B in combination with cannabidiol against Acinetobacter baumannii: a metabolomic study

Hussein, Maytham, Allobawi, Rafah, Levou, Irini, Blaskovich, Mark A. T., Rao, Gauri G., Li, Jian and Velkov, Tony (2022). Mechanisms underlying synergistic killing of Polymyxin B in combination with cannabidiol against Acinetobacter baumannii: a metabolomic study. Pharmaceutics, 14 (4) 786. doi: 10.3390/pharmaceutics14040786

Amino alcohols as potential antibiotic and antifungal leads

Baker, Jennifer R., Cossar, Peter J., Blaskovich, Mark A. T., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Lewis, Peter J. and McCluskey, Adam (2022). Amino alcohols as potential antibiotic and antifungal leads. Molecules, 27 (7) 2050. doi: 10.3390/molecules27072050

Nanomaterials: the new antimicrobial magic bullet

Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Falconer, James Robert and Blaskovich, Mark A. T. (2022). Nanomaterials: the new antimicrobial magic bullet. ACS Infectious Diseases, 8 (4), 693-712. doi: 10.1021/acsinfecdis.1c00660

Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole

Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Blaskovich, Mark A.T. and Falconer, James Robert (2022). Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole. International Journal of Pharmaceutics, 616 121487, 121487. doi: 10.1016/j.ijpharm.2022.121487

Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents

Skwarczynski, Mariusz, Bashiri, Sahra, Yuan, Ye, Ziora, Zyta M., Nabil, Osama, Masuda, Keita, Khongkow, Mattaka, Rimsueb, Natchanon, Cabral, Horacio, Ruktanonchai, Uracha, Blaskovich, Mark A. T. and Toth, Istvan (2022). Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents. Antibiotics, 11 (3) 412, 412. doi: 10.3390/antibiotics11030412

Featured article editorial: discovery of a tricyclic β-lactam active against carbapenem-resistant enterobacterales

Blaskovich, Mark (2022). Featured article editorial: discovery of a tricyclic β-lactam active against carbapenem-resistant enterobacterales. ACS Infectious Diseases, 8 (3) acsinfecdis.2c00088, 398-398. doi: 10.1021/acsinfecdis.2c00088

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586

Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds

Mirzaee, Hooman, Ariens, Emily, Blaskovich, Mark A. T., Clark, Richard J. and Schenk, Peer M. (2021). Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds. Pharmaceuticals, 14 (12) 1232, 1232. doi: 10.3390/ph14121232

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

Conners, Rebecca, McLaren, Mathew, Łapińska, Urszula, Sanders, Kelly, Stone, M. Rhia L., Blaskovich, Mark A. T., Pagliara, Stefano, Daum, Bertram, Rakonjac, Jasna and Gold, Vicki A. M. (2021). CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage. Nature Communications, 12 (1) 6316, 6316. doi: 10.1038/s41467-021-26610-3

Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment

Jain, Marut, Khan, Sadaf Aiman, Pandey, Ashish, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A.T. (2021). Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment. Science of The Total Environment, 793 148583, 1-19. doi: 10.1016/j.scitotenv.2021.148583

Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold

Zhang, Chen, Lum, Kah Yean, Taki, Aya C., Gasser, Robin B., Byrne, Joseph J., Wang, Tao, Blaskovich, Mark A.T., Register, Emery T., Montaner, Luis J., Tietjen, Ian and Davis, Rohan A. (2021). Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold. Phytochemistry, 190 112887, 1-10. doi: 10.1016/j.phytochem.2021.112887

Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae

Bettoni, Serena, Maziarz, Karolina, Stone, M. Rhia L., Blaskovich, Mark A. T., Potempa, Jan, Bazzo, Maria Luiza, Unemo, Magnus, Ram, Sanjay and Blom, Anna M. (2021). Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae. Frontiers in Immunology, 12 726801, 1-15. doi: 10.3389/fimmu.2021.726801

Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles

Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807

Antibiotic alternatives special issue

Blaskovich, Mark A. T. (2021). Antibiotic alternatives special issue. ACS Infectious Diseases, 7 (8), 2025-2026. doi: 10.1021/acsinfecdis.1c00388

Targeted protein degradation: the new frontier of antimicrobial discovery?

Powell, Matthew, Blaskovich, Mark A. T. and Hansford, Karl A. (2021). Targeted protein degradation: the new frontier of antimicrobial discovery?. ACS Infectious Diseases, 7 (8) acsinfecdis.1c00203, 2050-2067. doi: 10.1021/acsinfecdis.1c00203

Antimicrobial screening of a historical collection of over 140 000 small molecules

Semenov, Victor V., Raihstat, Mikhail M., Konyushkin, Leonid D., Semenov, Roman V., Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G., Hansford, Karl A. and Cooper, Matthew A. (2021). Antimicrobial screening of a historical collection of over 140 000 small molecules. Mendeleev Communications, 31 (4), 484-487. doi: 10.1016/j.mencom.2021.07.015

The antimicrobial resistance crisis: an inadvertent, unfortunate but nevertheless informative experiment in evolutionary biology

Michael, Carolyn A., Gillings, Michael R., Blaskovich, Mark A. T. and Franks, Ashley E. (2021). The antimicrobial resistance crisis: an inadvertent, unfortunate but nevertheless informative experiment in evolutionary biology. Frontiers in Ecology and Evolution, 9 692674. doi: 10.3389/fevo.2021.692674

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767

There is no market for new antibiotics: this allows an open approach to research and development

Klug, Dana M., Idiris, Fahima I. M., Blaskovich, Mark A. T., von Delft, Frank, Dowson, Christopher G., Kirchhelle, Claas, Roberts, Adam P., Singer, Andrew C. and Todd, Matthew H. (2021). There is no market for new antibiotics: this allows an open approach to research and development. Wellcome Open Research, 6 146, 146. doi: 10.12688/wellcomeopenres.16847.1

Virtual Issue: Anti-infective Discovery Down Under

Blaskovich, Mark (2021). Virtual Issue: Anti-infective Discovery Down Under. ACS Infectious Diseases, 7 (6), 1555-1557. doi: 10.1021/acsinfecdis.1c00196

In Vitro activity of vancapticin MCC5145 against methicillin-resistant Staphylococcus aureus from periprosthetic joint infection

Cho, Hye-Kyung, Karau, Melissa J., Greenwood-Quaintance, Kerryl E., Hansford, Karl A., Cooper, Matthew A., Blaskovich, Mark A. T. and Patel, Robin (2021). In Vitro activity of vancapticin MCC5145 against methicillin-resistant Staphylococcus aureus from periprosthetic joint infection. Antimicrobial Agents and Chemotherapy, 65 (5) e02443-20. doi: 10.1128/aac.02443-20

Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus

Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716

Bio-potency and molecular docking studies of isolated compounds from Grewia optiva J.R. Drumm. ex Burret

Ul Bari, Wasim, Ur Rehman, Najeeb, Khan, Ajmal, Ahsan Halim, Sobia, Yuan, Ye, Blaskovich, Mark A.T., Ziora, Zyta M., Zahoor, Muhammad, Naz, Sumaira, Ullah, Riaz, Alotaibi, Amal and Al-Harrasi, Ahmed (2021). Bio-potency and molecular docking studies of isolated compounds from Grewia optiva J.R. Drumm. ex Burret. Molecules, 26 (7) 2019, 2019. doi: 10.3390/molecules26072019

Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

Ndayishimiye, John, Popat, Amirali, Kumeria, Tushar, Blaskovich, Mark A.T. and Falconer, James Robert (2021). Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution. International Journal of Pharmaceutics, 596 120240, 120240. doi: 10.1016/j.ijpharm.2021.120240

Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021)

Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021). Chemistry – A European Journal, 27 (6), 1861-1861. doi: 10.1002/chem.202004912

Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity

Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity. Chemistry – A European Journal, 27 (6), 2021-2029. doi: 10.1002/chem.202003545

The antimicrobial potential of cannabidiol

Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y

Formulation of quaternized aminated chitosan nanoparticles for efficient encapsulation and slow eelease of curcumin

Omer, Ahmed M., Ziora, Zyta M., Tamer, Tamer M., Khalifa, Randa E., Hassan, Mohamed A., Mohy-Eldin, Mohamed S. and Blaskovich, Mark A. T. (2021). Formulation of quaternized aminated chitosan nanoparticles for efficient encapsulation and slow eelease of curcumin. Molecules, 26 (2) 449, 1-14. doi: 10.3390/molecules26020449

Current perspective of innovative strategies for bioremediation of organic pollutants from wastewater

Jain, Marut, Khan, Sadaf Aiman, Sharma, Komal, Jadhao, Prashant Ram, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A.T. (2021). Current perspective of innovative strategies for bioremediation of organic pollutants from wastewater. Bioresource Technology, 344 (Pt B) 126305, 126305. doi: 10.1016/j.biortech.2021.126305

Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin

Ndayishimiye, John, Cao, Yuxue, Kumeria, Tushar, Blaskovich, Mark A. T., Falconer, James Robert and Popat, Amirali (2021). Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin. Journal of Materials Chemistry B, 9 (35), 7145-7166. doi: 10.1039/d1tb01430g

Platinum cyclooctadiene complexes with activity against gram-positive bacteria

Frei, Angelo, Ramu, Soumya, Lowe, Gabrielle J., Dinh, Hue, Semenec, Lucie, Elliott, Alysha G., Zuegg, Johannes, Deckers, Anke, Jung, Nicole, Bräse, Stefan, Cain, Amy K. and Blaskovich, Mark A. T. (2021). Platinum cyclooctadiene complexes with activity against gram-positive bacteria. ChemMedChem, 16 (20) cmdc.202100157, 1-8. doi: 10.1002/cmdc.202100157

Syzygium cumini(L.),Skeels fruit extracts: in vitro and in vivo anti-inflammatory properties

Qamar, Muhammad, Akhtar, Saeed, Ismail, Tariq, Yuan, Ye, Ahmad, Naveed, Tawab, Abdul, Ismail, Amir, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark.A.T. and Ziora, Zyta M. (2021). Syzygium cumini(L.),Skeels fruit extracts: in vitro and in vivo anti-inflammatory properties. Journal of Ethnopharmacology, 271 113805, 1-12. doi: 10.1016/j.jep.2021.113805

Multi-institution research and education collaboration identifies new antimicrobial compounds

Fuller, Amelia A., Dounay, Amy B., Schirch, Douglas, Rivera, Daniel G., Hansford, Karl A., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Blaskovich, Mark A. T., Hitchens, Jacob R., Burris-Hiday, Sarah, Tenorio, Kristiana, Mendez, Yanira, Samaritoni, J. Geno, O’Donnell, Martin J. and Scott, William L. (2020). Multi-institution research and education collaboration identifies new antimicrobial compounds. ACS Chemical Biology, 15 (12), 3187-3196. doi: 10.1021/acschembio.0c00732

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791

Call for Papers: Antibiotic Alternatives Special Issue

Blaskovich, Mark. A. T. (2020). Call for Papers: Antibiotic Alternatives Special Issue. ACS Infectious Diseases, 6 (11), 2812-2812. doi: 10.1021/acsinfecdis.0c00663

Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides

Ndayishimiye, John, Popat, Amirali, Blaskovich, Mark and Falconer, James Robert (2020). Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides. Journal of Controlled Release, 324, 728-749. doi: 10.1016/j.jconrel.2020.05.002

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x

Antibiotics special issue: Challenges and opportunities in antibiotic discovery and development

Blaskovich, Mark A. T. (2020). Antibiotics special issue: Challenges and opportunities in antibiotic discovery and development. ACS Infectious Diseases, 6 (6), 1286-1288. doi: 10.1021/acsinfecdis.0c00331

How to stimulate and facilitate early stage antibiotic discovery

Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163

Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020)

Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher G., Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M., Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna K., Rutledge, Peter J., Sadler, Peter J., Todd, Matthew H., Willans, Charlotte E., Wilson, Justin J., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020). Chemical Science, 11 (17), 4531-4531. doi: 10.1039/d0sc90075c

Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model

Rineh, Ardeshir, Soren, Odel, McEwan, Timothy, Ravikumar, Vikashini, Poh, Wee Han, Azamifar, Fereshteh, Naimi-Jamal, M. Reza, Cheung, Chen-Yi, Elliott, Alysha G., Zuegg, Johannes, Blaskovich, Mark A. T., Cooper, Matthew A., Dolange, Victoria, Christodoulides, Myron, Cook, Gregory M., Rice, Scott A., Faust, Saul N., Webb, Jeremy S. and Kelso, Michael J. (2020). Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model. ACS Infectious Diseases, 6 (6) acsinfecdis.0c00070, 1460-1479. doi: 10.1021/acsinfecdis.0c00070

Complete genome sequences of clinical Pandoraea fibrosis isolates

Pitt, Miranda E., Nguyen, Son H., Duarte, Tânia P. S., Roddam, Louise F., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2020). Complete genome sequences of clinical Pandoraea fibrosis isolates. Microbiology Resource Announcements, 9 (13) e00060-20. doi: 10.1128/mra.00060-20

Metal complexes as a promising source for new antibiotics

Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e

Light-activated rhenium complexes with dual mode of action against bacteria

Frei, Angelo, Amado, Maite, Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Light-activated rhenium complexes with dual mode of action against bacteria. Chemistry: A European Journal, 26 (13) chem.201904689, 2762-2762. doi: 10.1002/chem.201904689

Visualization of bacterial resistance using fluorescent antibiotic probes

Stone, M. Rhia L., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Visualization of bacterial resistance using fluorescent antibiotic probes. Journal of Visualized Experiments, 2020 (157) e60743. doi: 10.3791/60743

Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing

Pitt, Miranda E., Nguyen, Son H., Duarte, Tânia P. S., Teng, Haotian, Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2020). Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing. GigaScience, 9 (2), 1-14. doi: 10.1093/gigascience/giaa002

Flow-cytometry detection of fluorescent magnetic nanoparticle clusters increases sensitivity of dengue immunoassay

Sanjaya, K.C., Ranzoni, Andrea, Hung, Jacky, Blaskovich, Mark A.T., Watterson, Daniel, Young, Paul R. and Cooper, Matthew A. (2020). Flow-cytometry detection of fluorescent magnetic nanoparticle clusters increases sensitivity of dengue immunoassay. Analytica Chimica Acta, 1107, 85-91. doi: 10.1016/j.aca.2020.02.007

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Ang, Chee Wei, Tan, Lendl, Sykes, Melissa L., Abugharbiyeh, Neda, Debnath, Anjan, Reid, Janet C., West, Nicholas P., Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. Journal of Medicinal Chemistry, 63 (24), 15726-15751. doi: 10.1021/acs.jmedchem.0c01372

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c

Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance

Stone, M. Rhia L., Łapińska, Urszula, Pagliara, Stefano, Masi, Muriel, Blanchfield, Joanne T., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance. RSC Chemical Biology, 1 (5), 395-404. doi: 10.1039/d0cb00118j

Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies

Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722

Non-antibiotic small-molecule regulation of DHFR-based destabilizing domains in vivo

Peng, Hui, Chau, Viet Q., Phetsang, Wanida, Sebastian, Rebecca M., Stone, M. Rhia L., Datta, Shyamtanu, Renwick, Marian, Tamer, Yusuf T., Toprak, Erdal, Koh, Andrew Y., Blaskovich, Mark A.T. and Hulleman, John D. (2019). Non-antibiotic small-molecule regulation of DHFR-based destabilizing domains in vivo. Molecular Therapy - Methods and Clinical Development, 15, 27-39. doi: 10.1016/j.omtm.2019.08.002

Tyrosinase inhibitors as potential antibacterial agents

Yuan, Ye, Jin, Wanli, Nazir, Yasir, Fercher, Christian, Thomas Blaskovich, Mark A., Cooper, Matthew A., Barnard, Ross T. and Ziora, Zyta M. (2019). Tyrosinase inhibitors as potential antibacterial agents. European Journal of Medicinal Chemistry, 187 111892, 111892. doi: 10.1016/j.ejmech.2019.111892

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Brown, Peter, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M. F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W. K., Engel, Michael S., Chandrasekaran, Arun Richard, Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., van Raaij, Mark J., Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A. ... RELISH Consortium (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database-The Journal of Biological Databases and Curation, 2019, 1-67. doi: 10.1093/database/baz085

In vitro antimicrobial activity of acne drugs against skin-associated bacteria

Blaskovich, Mark A. T., Elliott, Alysha G., Kavanagh, Angela M., Ramu, Soumya and Cooper, Matthew A. (2019). In vitro antimicrobial activity of acne drugs against skin-associated bacteria. Scientific Reports, 9 (1) 14658, 14658. doi: 10.1038/s41598-019-50746-4

Call for Papers: Antibiotics Special Issue

Blaskovich, Mark A. T. (2019). Call for Papers: Antibiotics Special Issue. ACS Infectious Diseases, 5 (8) acsinfecdis.0c00663, 1264-1264. doi: 10.1021/acsinfecdis.9b00262

Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs

Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238

The eagle effect and antibiotic-induced persistence: two sides of the same coin?

Prasetyoputri, Anggia, Jarrad, Angie M., Cooper, Matthew A. and Blaskovich, Mark A.T. (2019). The eagle effect and antibiotic-induced persistence: two sides of the same coin?. Trends in Microbiology, 27 (4), 339-354. doi: 10.1016/j.tim.2018.10.007

Structure-function studies of polymyxin B lipononapeptides

Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019). Structure-function studies of polymyxin B lipononapeptides. Molecules, 24 (3) 553, 553. doi: 10.3390/molecules24030553

Effects of microplate type and broth additives on microdilution MIC susceptibility assays

Kavanagh, Angela, Ramu, Soumya, Gong, Yujing, Cooper, Matthew A. and Blaskovich, Mark A. T. (2019). Effects of microplate type and broth additives on microdilution MIC susceptibility assays. Antimicrobial Agents and Chemotherapy, 63 (1) e01760-18. doi: 10.1128/aac.01760-18

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

Stone, M. Rhia L., Masi, Muriel, Phetsang, Wanida, Pagès, Jean-Marie, Cooper, Matthew A. and Blaskovich, Mark A. T. (2019). Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux. MedChemComm, 10 (6), 901-906. doi: 10.1039/c9md00124g

Quinolone antibiotics

Pham, Thu D. M., Ziora, Zyta M. and Blaskovich, Mark A. T. (2019). Quinolone antibiotics. MedChemComm, 10 (10), 1719-1739. doi: 10.1039/c9md00120d

The diminished antimicrobial pipeline

Blaskovich, Mark A.T. (2019). The diminished antimicrobial pipeline. Microbiology Australia, 40 (2), 92-96. doi: 10.1071/MA19025

Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity

Jarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T. and Cooper, Matthew A. (2018). Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry, 61 (24) acs.jmedchem.8b01578, 11349-11371. doi: 10.1021/acs.jmedchem.8b01578

Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate

Pitt, Miranda E., Cao, Minh Duc, Butler, Mark S., Ramu, Soumya, Ganesamoorthy, Devika, Blaskovich, Mark A. T., Coin, Lachlan J. M. and Cooper, Matthew A. (2018). Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate. The Journal of Antimicrobial Chemotherapy, 74 (3), 582-593. doi: 10.1093/jac/dky458

Antimicrobial silver in medicinal and consumer applications: a patent review of the past decade (2007–2017)

Sim, Wilson, Barnard, Ross, Blaskovich, M.A.T. and Ziora, Zyta (2018). Antimicrobial silver in medicinal and consumer applications: a patent review of the past decade (2007–2017). Antibiotics, 7 (4) 93, 93. doi: 10.3390/antibiotics7040093

Silver bullets: a new lustre on an old antimicrobial agent

Möhler, Jasper S., Sim, Wilson, Blaskovich, Mark A. T., Cooper, Matthew A. and Ziora, Zyta M. (2018). Silver bullets: a new lustre on an old antimicrobial agent. Biotechnology Advances, 36 (5), 1391-1411. doi: 10.1016/j.biotechadv.2018.05.004

Detection and investigation of Eagle effect resistance to vancomycin in Clostridium difficile with an ATP-bioluminescence assay

Jarrad, Angie M., Blaskovich, Mark A. T., Prasetyoputri, Anggia, Karoli, Tomislav, Hansford, Karl A. and Cooper, Matthew A. (2018). Detection and investigation of Eagle effect resistance to vancomycin in Clostridium difficile with an ATP-bioluminescence assay. Frontiers in Microbiology, 9 (JUL) 1420, 1420. doi: 10.3389/fmicb.2018.01420

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018). Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 (6), 485-499. doi: 10.1080/14787210.2018.1483240

The fight against antimicrobial resistance is confounded by a global increase in antibiotic usage

Blaskovich, Mark A. T. (2018). The fight against antimicrobial resistance is confounded by a global increase in antibiotic usage. ACS Infectious Diseases, 4 (6), 868-870. doi: 10.1021/acsinfecdis.8b00109

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

Stone, M Rhia L., Butler, Mark S., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2018). Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance. Trends in Biotechnology, 36 (5), 523-536. doi: 10.1016/j.tibtech.2018.01.004

Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae

Pitt, Miranda E., Elliott, Alysha G., Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2018). Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microbial Genomics, 4 (3) 000158. doi: 10.1099/mgen.0.000158

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005

Developments in Glycopeptide Antibiotics

Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Jia, ZhiGuang, Mark, Alan E. and Cooper, Matthew A. (2018). Developments in Glycopeptide Antibiotics. ACS Infectious Diseases, 4 (5), 715-735. doi: 10.1021/acsinfecdis.7b00258

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w

A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase

Paparella, Ashleigh S., Feng, Jiage, Blanco-Rodriguez, Beatriz, Feng, Zikai, Phetsang, Wanida, Blaskovich, Mark A. T., Cooper, Matthew A., Booker, Grant W., Polyak, Steven W. and Abell, Andrew D. (2017). A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase. Tetrahedron, 74 (12), 1175-1183. doi: 10.1016/j.tet.2017.10.032

Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1

Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017). Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 (12), 917-926. doi: 10.1021/acsinfecdis.7b00123

Nitroimidazoles: Molecular fireworks that combat a broad spectrum of infectious diseases

Ang, Chee Wei, Jarrad, Angie M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Nitroimidazoles: Molecular fireworks that combat a broad spectrum of infectious diseases. Journal of Medicinal Chemistry, 60 (18), 7636-7657. doi: 10.1021/acs.jmedchem.7b00143

Investigating the interaction of octapeptin A3 with model bacterial membranes

Han, Mei-Ling, Shen, Hsin-Hui, Hansford, Karl A., Schneider, Elena K., Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Le Brun, Anton P., Zhu, Yan, Sani, Marc-Antoine, Separovic, Frances, Blaskovich, Mark A. T., Baker, Mark A., Moskowitz, Samuel M., Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). Investigating the interaction of octapeptin A3 with model bacterial membranes. ACS Infectious Diseases, 3 (8), 606-619. doi: 10.1021/acsinfecdis.7b00065

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators

Hussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 (5), 640-650. doi: 10.1089/mdr.2016.0196

Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017). Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2407-2409. doi: 10.1016/j.bmcl.2017.04.027

Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals

Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 (2) FSO171, FSO171. doi: 10.4155/fsoa-2016-0093

Polishing the tarnished silver bullet: the quest for new antibiotics

Blaskovich, Mark A. T., Butler, Mark S. and Cooper, Matthew A. (2017). Polishing the tarnished silver bullet: the quest for new antibiotics. Antimicrobial Resistance, 61 (1), 103-114. doi: 10.1042/EBC20160077

Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies

Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028

Unusual amino acids in medicinal chemistry

Blaskovich, Mark A. T. (2016). Unusual amino acids in medicinal chemistry. Journal of Medicinal Chemistry, 59 (24), 10807-10836. doi: 10.1021/acs.jmedchem.6b00319

Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteria

Hassan, Marwa Hussain Ali, Ranzoni, Andrea, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteria. Bioconjugate Chemistry, 28 (2), 353-361. doi: 10.1021/acs.bioconjchem.6b00494

Old dogs and new tricks in antimicrobial discovery

Butler, Mark, Blaskovich, Mark, Owen, Jeremy G. and Cooper, Matthew (2016). Old dogs and new tricks in antimicrobial discovery. Current Opinion in Microbiology, 33, 25-34. doi: 10.1016/j.mib.2016.05.011

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M., Debnath, A., Miyamoto, Y., Hansford, K. A., Pelingon, R., Butler, M. S., Bains, T., Karoli, T., Blaskovich, M. A. T., Eckmann, L. and Cooper, M. A. (2016). Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. European Journal of Medicinal Chemistry, 120, 353-362. doi: 10.1016/j.ejmech.2016.04.064

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

Croker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43

Antibiotics in the clinical pipeline at the end of 2015

Butler, Mark S., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Antibiotics in the clinical pipeline at the end of 2015. The Journal of Antibiotics, 70 (1), 1-22. doi: 10.1038/ja.2016.72

Chemical philanthropy: a path forward for antibiotic discovery?

Hansford, Karl A., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Chemical philanthropy: a path forward for antibiotic discovery?. Future Medicinal Chemistry, 8 (9), 925-929. doi: 10.4155/fmc-2016-0029

Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053

Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides

Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045

Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B

Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593

Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli

Phetsang, Wanida, Pelingon, Ruby, Butler, Mark S., KC, Sanjaya, Pitt, Miranda, Kaeslin, Geraldine, Cooper, Matthew A. and Blaskovich, Mark A. T. (2016). Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli. ACS Infectious Diseases, 2 (10), 688-701. doi: 10.1021/acsinfecdis.6b00080

Clostridium difficile infection: current and emerging therapeutics

Jarrad, Angie M., Blaskovich, Mark A. T., Lyras, Dena and Cooper, Matthew A. (2015). Clostridium difficile infection: current and emerging therapeutics. Current Treatment Options in Infectious Diseases, 7 (4), 317-334. doi: 10.1007/s40506-015-0062-4

Mucin binding reduces colistin antimicrobial activity

Huang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015). Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 (10), 5925-5931. doi: 10.1128/AAC.00808-15

Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites

Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019

Clostridium difficile drug pipeline: challenges in discover and development of new agents

Jarrad, Angie M., Karoli, Tomislav, Blaskovich, Mark A.T., Lyras, Dena and Cooper, Matthew A. (2015). Clostridium difficile drug pipeline: challenges in discover and development of new agents. Journal of Medicinal Chemistry, 58 (13), 5164-5185. doi: 10.1021/jm5016846

A new antibiotic with potent activity targets MscL

Iscla, Irene, Wray, Robin, Blount, Paul, Larkins-Ford, Johah, Conery, Annie L., Ausubel, Frederick M., Ramu, Soumya, Kavanagh, Angela, Huang, Johnny X., Blaskovich, Mark A., Cooper, Matthew A., Obregon-Henao, Andres, Orme, Ian, Tjandra, Edwin S., Stroeher, Uwe H., Brown, Melissa H., Macardle, Cindy, van Holst, Nick, Tong, Chee Ling, Slattery, Ashley D., Gibson, Christopher T., Raston, Colin L. and Boulos, Ramiz A. (2015). A new antibiotic with potent activity targets MscL. The Journal of Antibiotics, 68 (7), 453-462. doi: 10.1038/ja.2015.4

Helping chemists discover new antibiotics

Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044

Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells

Huang, Johnny Xiao, Geraldine Kaeslin, Max Ranall, Blaskovich, Mark, Bernd Becker, Butler, Mark, Little, Melissa H., Lash, Lawrence H. and Cooper, Matthew (2015). Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells. Pharmacology Research and Perspectives, 3 (3) e00148, e00148. doi: 10.1002/prp2.148

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137

Cell- and biomarker-based assays for predicting nephrotoxicity

Huang, Johnny X., Blaskovich, Mark A. and Cooper, Matthew A. (2014). Cell- and biomarker-based assays for predicting nephrotoxicity. Expert Opinion on Drug Metabolism and Toxicology, 10 (12), 1621-1635. doi: 10.1517/17425255.2014.967681

Glycopeptide antibiotics: back to the future

Butler, Mark S., Hansford, Karl A., Blaskovich, Mark A. T., Halai, Reena and Cooper, Matthew A. (2014). Glycopeptide antibiotics: back to the future. Journal of Antibiotics, 67 (9), 631-644. doi: 10.1038/ja.2014.111

An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

Phetsang, Wanida, Blaskovich, Mark A. T., Butler, Mark S., Huang, Johnny Xiao, Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M. and Cooper, Matthew A. (2014). An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants. Bioorganic and Medicinal Chemistry, 22 (16), 4490-4498. doi: 10.1016/j.bmc.2014.05.054

Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

Cheng, Mu, Ziora, Zyta M., Hansford, Karl A., Blaskovich, Mark A., Butler, Mark S. and Cooper, Matthew A. (2014). Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin. Organic and Biomolecular Chemistry, 12 (16), 2568-2575. doi: 10.1039/c3ob42428f

ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2013). ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery. ChemInform, 44 (43), no-no. doi: 10.1002/chin.201343267

Antibiotics in the clinical pipeline in 2013

Butler, Mark S., Blaskovich, Mark A. and Cooper, Matthew A. (2013). Antibiotics in the clinical pipeline in 2013. Journal of Antibiotics, 66 (10), 571-591. doi: 10.1038/ja.2013.86

Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca

Barnes, Emma C., Kavanagh, Angela M., Ramu, Soumya, Blaskovich, Mark A., Cooper, Matthew A. and Davis, Rohan A. (2013). Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca. Phytochemistry, 93, 162-169. doi: 10.1016/j.phytochem.2013.02.021

Resolving biofilm infections: current therapy and drug discovery strategies

Ranall, Max V., Butler, Mark S., Blaskovich, Mark A. and Cooper, Matthew A. (2012). Resolving biofilm infections: current therapy and drug discovery strategies. Current Drug Targets, 13 (11), 1375-1385. doi: 10.2174/138945012803530251

Lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2012). Lipoamino acids as major components of absorption promoters in drug delivery. Current Topics in Medicinal Chemistry, 12 (14), 1562-1580. doi: 10.2174/156802612802652448

Drug discovery and protein tyrosine phosphatases

Blaskovich, M. A. T. (2009). Drug discovery and protein tyrosine phosphatases. Current Medicinal Chemistry, 16 (17), 2095-2176. doi: 10.2174/092986709788612693

A convenient reduction of α-amino acids to 1,2-amino alcohols with retention of optical purity

Hwang, Sun-Hee, Blaskovich, Mark A. and Kim, Hwa-Ok (2008). A convenient reduction of α-amino acids to 1,2-amino alcohols with retention of optical purity. Open Organic Chemistry Journal, 2 (1), 107-109. doi: 10.2174/1874095200802010107

Design and synthesis of phosphotyrosine mimetics

Yan, Zheng, Kahn, Michael, Qabar, Maher, Urban, Jan, Kim, Hwa-Ok and Blaskovich, Mark (2003). Design and synthesis of phosphotyrosine mimetics. Bioorganic & Medicinal Chemistry Letters, 13 (12), 2083-2085. doi: 10.1016/S0960-894X(03)00253-1

Recent discovery and development of protein tyrosine phosphatase inhibitors

Blaskovich, Mark A. and Kim, Hwa-Ok (2002). Recent discovery and development of protein tyrosine phosphatase inhibitors. Expert Opinion on Therapeutic Patents, 12 (6), 871-905. doi: 10.1517/13543776.12.6.871

Preparation of 1-[N-Benzyloxycarbonyl-(1S)-1-amino-2-oxoethyl]-4-methyl-2,6,7-trioxabicyclo-[2.2.2]octane

Rose, Nicholas G.W., Blaskovich, Mark A., Evindar, Ghotas, Wilkinson, Scott, Luo, Yue, Reid, C. and Lajoie, Gilles A. (2002). Preparation of 1-[N-Benzyloxycarbonyl-(1S)-1-amino-2-oxoethyl]-4-methyl-2,6,7-trioxabicyclo-[2.2.2]octane. Organic syntheses, 79, 216-221. doi: 10.1002/0471264180.os079.26

Preparation of 1-[N-benzyloxycarbonyl-(1S)-1-amino-2-oxoethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2] octane: [Carbamic acid, [1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-2-oxoethyl]-, phenylmethyl ester, (S)-]

Rose, Nicholas G. W., Blaskovich, Mark A., Evindar, Ghotas, Wilkinson, Scott, Luo, Yue, Fishlock, Dan, Reid, Chris, Lajoie, Gilles A., Gordon, Richard S. and Holmes, Andrew B. (2002). Preparation of 1-[N-benzyloxycarbonyl-(1S)-1-amino-2-oxoethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2] octane: [Carbamic acid, [1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-2-oxoethyl]-, phenylmethyl ester, (S)-]. Organic Syntheses, 79 doi: 10.15227/orgsyn.079.0216

Synthesis of enantiomerically enriched beta,gamma-unsaturated-alpha-amino acids

Rose, Ngw, Blaskovich, MA, Wong, A and Lajoie, GA (2001). Synthesis of enantiomerically enriched beta,gamma-unsaturated-alpha-amino acids. Tetrahedron, 57 (8), 1497-1507. doi: 10.1016/S0040-4020(00)01146-7

Stereoselective synthesis of beta-substituted alpha,beta-diamino acids from beta-hydroxy amino acids

Luo, Y, Blaskovich, MA and Lajoie, GA (1999). Stereoselective synthesis of beta-substituted alpha,beta-diamino acids from beta-hydroxy amino acids. Journal of Organic Chemistry, 64 (16), 6106-6111. doi: 10.1021/jo9904718

Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics

Ogbu, CO, Qabar, MN, Boatman, PD, Urban, J, Meara, JP, Ferguson, MD, Tulinsky, J, Lum, C, Babu, S, Blaskovich, MA, Nakanishi, H, Ruan, FQ, Cao, BL, Minarik, R, Little, T, Nelson, S, Nguyen, M, Gall, A and Kahn, M (1998). Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics. Bioorganic & Medicinal Chemistry Letters, 8 (17), 2321-2326. doi: 10.1016/S0960-894X(98)00420-X

Polymer-supported acetylide addition to hexa-2,4-dienal

Blaskovich, MA and Kahn, M (1998). Polymer-supported acetylide addition to hexa-2,4-dienal. Synthesis-Stuttgart (7), 965-966.

Stereoselective synthesis of Threo and Erythro beta-hydroxy and beta-disubstituted-beta-hydroxy alpha-amino acids (vol 63, pg 3635, 1998)

Blaskovich, MA, Evindar, G, Rose, NGW, Wilkinson, S, Luo, Y and Lajoie, GA (1998). Stereoselective synthesis of Threo and Erythro beta-hydroxy and beta-disubstituted-beta-hydroxy alpha-amino acids (vol 63, pg 3635, 1998). Journal of Organic Chemistry, 63 (13), 4560-4560. doi: 10.1021/jo9849853

Regiocontrol in alkylations of alpha-silyl hydrazones

Blaskovich, MA and Rickards, RW (1998). Regiocontrol in alkylations of alpha-silyl hydrazones. Tetrahedron Letters, 39 (21), 3617-3620. doi: 10.1016/S0040-4039(98)00564-4

Stereoselective synthesis of threo and erythro beta-hydroxy and beta-disubstituted-beta-hydroxy alpha-amino acids

Blaskovich, MA, Evindar, G, Rose, NGW, Wilkinson, S, Luo, Y and Lajoie, GA (1998). Stereoselective synthesis of threo and erythro beta-hydroxy and beta-disubstituted-beta-hydroxy alpha-amino acids. Journal of Organic Chemistry, 63 (11), 3631-3646. doi: 10.1021/jo972294l

Mild conditions for oxazolidin-5-one formation

Blaskovich, MA and Kahn, M (1998). Mild conditions for oxazolidin-5-one formation. Synthesis-Stuttgart (4), 379-380.

Solid-phase preparation of dienes

Blaskovich, MA and Kahn, M (1998). Solid-phase preparation of dienes. Journal of Organic Chemistry, 63 (4), 1119-1125. doi: 10.1021/jo9715884

Stereoselective Synthesis of Allo-Threonine and Beta-H-2-Allo-Threonine From Threonine

Blaskovich, MA and Lajoie, GA (1993). Stereoselective Synthesis of Allo-Threonine and Beta-H-2-Allo-Threonine From Threonine. Tetrahedron Letters, 34 (24), 3837-3840. doi: 10.1016/S0040-4039(00)79241-0

Synthesis of a Chiral Serine Aldehyde Equivalent and its Conversion to Chiral Alpha-Amino-Acid Derivatives

Blaskovich, MA and Lajoie, GA (1993). Synthesis of a Chiral Serine Aldehyde Equivalent and its Conversion to Chiral Alpha-Amino-Acid Derivatives. Journal of the American Chemical Society, 115 (12), 5021-5030. doi: 10.1021/ja00065a010

Simple and Convenient Synthesis of Tert-Butyl Ethers of Fmoc-Serine, Fmoc-Threonine, and Fmoc-Tyrosine

Adamson, JG, Blaskovich, MA, Groenevelt, H and Lajoie, GA (1991). Simple and Convenient Synthesis of Tert-Butyl Ethers of Fmoc-Serine, Fmoc-Threonine, and Fmoc-Tyrosine. Journal of Organic Chemistry, 56 (10), 3447-3449. doi: 10.1021/jo00010a050

Developing the monitoring and evaluation framework for ‘Australia’s antimicrobial resistance strategy: 2020 and beyond’ using a one health approach

Hall, Lisa, Lawler, Sheleigh, Comans, Tracy, Reid, Simon, Soares Magalhães, Ricardo, Blaskovich, Mark, Henseleit, Julia and Welch, Alyssa (2023). Developing the monitoring and evaluation framework for ‘Australia’s antimicrobial resistance strategy: 2020 and beyond’ using a one health approach. 17th World Congress on Public Health, Rome, Italy, 2-6 May 2023. Heraklion, Greece: EU European Publishing. doi: 10.18332/popmed/163919

Developing the monitoring and evaluation framework for ‘Australia’s antimicrobial resistance strategy: 2020 and beyond’ using a one health approach

Hall, Lisa, Lawler, Sheleigh, Comans, Tracy, Reid, Simon, Magalhães, Ricardo Soares, Blaskovich, Mark, Henseleit, Julia and Welch, Alyssa (2023). Developing the monitoring and evaluation framework for ‘Australia’s antimicrobial resistance strategy: 2020 and beyond’ using a one health approach. 17th World Congress on Public Health, Rome, Italy, 2-6 May 2023. Heraklion, Greece: European Publishing. doi: 10.18332/popmed/164014

WS1.4: Biostimulation of bacteria for streamlined identification of new antimicrobial compounds

Mirzaee, Hooman, Ariens, Emily, Booth, James, Carvalhais, Lilia C., Blaskovich, Mark A.T., Clark, Richard J. and Schenk, Peer M. (2022). WS1.4: Biostimulation of bacteria for streamlined identification of new antimicrobial compounds. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, WA Australia, 27 – 30 November 2022. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/s2213-7165(22)00272-7

Antibiotic-derived molecular probes for bacterial imaging

Blaskovich, Mark A., Phetsang, Wanida, Stone, M. Rhia L., Lapinska, Urszula, Pagliara, Stefano, Bhalla, Rajiv and Cooper, Matthew A. (2019). Antibiotic-derived molecular probes for bacterial imaging. SPIE BiOS 2019, San Francisco, California, 2-7 February 2019. Bellingham, WA United States: SPIE - International Society for Optical Engineering. doi: 10.1117/12.2507329

Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides

Edwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950

New glycopeptidic antibiotics to combat multidrug resistant pathogens

Gong, Y., Muldoon, C. A., Premraj, R., Ziora, Z. M., Bradford, T. A., Cheng, M., Ramu, S., Huang, J. X., Kavanagh, A., Pelingon, R., Lee, J. C., Wong, K., Butler, M. S., Blaskovich, M. A. and Cooper, M. A. (2012). New glycopeptidic antibiotics to combat multidrug resistant pathogens. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2449

4-substituted urazoles from amino acids: Useful building-blocks for the synthesis of beta-strand peptidomimetics.

Paparin, JL, Hwang, SH, Nguyen, M, Zheng, Y, Ruan, FQ, Little, T and Blaskovich, MA (2001). 4-substituted urazoles from amino acids: Useful building-blocks for the synthesis of beta-strand peptidomimetics.. WASHINGTON: AMER CHEMICAL SOC.

Design and synthesis of phosphotyrosine mimetic phenylalanine derivatives.

Kim, HO, Yan, Z, Blaskovich, M and Kahn, M (2001). Design and synthesis of phosphotyrosine mimetic phenylalanine derivatives.. WASHINGTON: AMER CHEMICAL SOC.

Facile synthesis of alpha-amino alcohols from alpha-amino acids.

Hwang, SH, Blaskovich, M and Kim, HO (2001). Facile synthesis of alpha-amino alcohols from alpha-amino acids.. WASHINGTON: AMER CHEMICAL SOC.

Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development

Blaskovich, MA, Boatman, PD, Cao, BL, Eguchi, M, Kim, HO, Lee, M, Little, T, Mathew, F, McCann, I, Mehlin, C, Nakanishi, H, Nelson, S, Nguyen, M, Ogbu, C, Qabar, MN, Ruan, FQ, Shea, JP, Stasiak, M, Urban, J and Kahn, M (2000). Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development. 16th American Peptide Symposium, Minneapolis Mn, Jun 26-Jul 01, 1999. DORDRECHT: SPRINGER.

Rapid Radiolabelling of Quinuclidinyl P-Iodobenzilate with I-123

Abeysekera, BF, Swinkels, HM, Blaskovich, MA, Reba, RC and Gibson, RE (1988). Rapid Radiolabelling of Quinuclidinyl P-Iodobenzilate with I-123. OTTAWA: CANADIAN MEDICAL ASSOCIATION.

Peptide Antibiotics

Matthew Cooper, Mark Blaskovich, Alejandra Gallardo-Godoy, Karl Hansford, Alysha Elliott, Carig Muldoon and Bernd Becker (2022). Peptide Antibiotics. US11279733.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2021). Antibacterial Agents. CN107027309.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2021). Antibacterial Agents. US10947271.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2020). Antibacterial Agents. EP3105244.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2019). Antibacterial Agents. JP6602318.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2019). Antibacterial Agents. AU2015/213478.

Peptide antibiotics

Gallardo-Goday, Alejandra, Cooper, Matthew, Blaskovich, Mark, Hansford, Karl and Elliott, Alysha (2019). Peptide antibiotics. WO2019084628.

Glycopeptide Antibiotic Constructs

Mark Blaskovich, Matt Cooper, Andrea Ranzoni, Wanida Phetsang and Marwa Hassan (2018). Glycopeptide Antibiotic Constructs. WO/2018/102889.

Visualisation Constructs

Mark Blaskovich, Matt Cooper, Mark Butler, Rhia Stone and Wanida Phetsang (2018). Visualisation Constructs. WO/2018/102890.

Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor

Mark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2016). Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor. US9340517.

Antibacterial Agents

Cooper, Matthew and Blaskovich, Mark (2015). Antibacterial Agents. WO/2015/117196.

3-Substituted-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists

Mark Arnold Thomas Blaskovich and Pater Joseph Cassidy (2013). 3-Substituted-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists. US8440653 .

Methods of Modulating The Activity of the MC5 Receptor and Treatment of Conditions Related to This Receptor

Mark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2013). Methods of Modulating The Activity of the MC5 Receptor and Treatment of Conditions Related to This Receptor. US8377925.

“3-Aminoalkyl-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists

Mark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2013). “3-Aminoalkyl-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists. US8343958.

3-Aminoalkyl-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists

Mark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2011). 3-Aminoalkyl-1,4-Diazepan-2-One Melanocortin-5 Receptor Antagonists. US8008291.

Protein Tyrosine Phosphatase Inhibitors and Methods of Use Thereof

Mark Arnold Thomas Blaskovich, Ted Baughman, Thomas Little, Maher Qabar, Lauri Marie Schultz, Feng Hong, William Pratt, Gangadhar Nagula, Jennifer Lynn Gage and James Jeffry Howbert (2010). Protein Tyrosine Phosphatase Inhibitors and Methods of Use Thereof. US7829737.

Modulating activity of melanocortin-1 receptor, delivering active agent to melanocortin-1 receptor, and for treating condition e.g. hyperpigmentation, and pain involves exposing melanocortin-1 receptor to substituted (1,4)diazepane compound

Blaskovich, Mark and CASSIDY P J (2010). Modulating activity of melanocortin-1 receptor, delivering active agent to melanocortin-1 receptor, and for treating condition e.g. hyperpigmentation, and pain involves exposing melanocortin-1 receptor to substituted (1,4)diazepane compound. WO2010096853-A1.

Modulating the activity of a receptor comprising melanocortin-3 receptor or melanocortin-4 receptor, comprises exposing the receptor to 1,4-diazepan-2-one compounds

Blaskovich, Mark and CASSIDY P J (2010). Modulating the activity of a receptor comprising melanocortin-3 receptor or melanocortin-4 receptor, comprises exposing the receptor to 1,4-diazepan-2-one compounds. WO2010096854-A1.

New 1,4-diazepan-2-one derivatives useful for treating, preventing or controlling condition e.g. acne, seborrheic dermatitis, acne vulgaris, acne fulminans, inflammation, and cancers

BLASKOVICH M A T and CASSIDY P J (2009). New 1,4-diazepan-2-one derivatives useful for treating, preventing or controlling condition e.g. acne, seborrheic dermatitis, acne vulgaris, acne fulminans, inflammation, and cancers. WO2009105825-A1.

New 1,4-diazepan-2-one derivatives useful for treating, preventing or controlling condition e.g. acne, seborrheic dermatitis, acne vulgaris, acne fulminans, inflammation, and cancers

BLASKOVICH M A T and CASSIDY P J (2009). New 1,4-diazepan-2-one derivatives useful for treating, preventing or controlling condition e.g. acne, seborrheic dermatitis, acne vulgaris, acne fulminans, inflammation, and cancers. WO2009105823-A1.

Use of 1,4-diazepan-2-one derivatives for down-regulating activity of melanocortin-5 receptor and treating, preventing or controlling a condition e.g. acne, and seborrheic dermatitis

BLASKOVICH M A T and CASSIDY P J, (2009). Use of 1,4-diazepan-2-one derivatives for down-regulating activity of melanocortin-5 receptor and treating, preventing or controlling a condition e.g. acne, and seborrheic dermatitis. WO2009105824-A1.

Protein Tyrosine Phosphatase Inhibitors and Methods of Use Thereof

Mark Arnold Thomas Blaskovich, Ted Baughman, Thomas Little, William Pratt, Maher Qabar, Laurie Marie Schultz, Gangadhar Nagula, Jennifer Lynn Gage and James Jeffry Howbert (2009). Protein Tyrosine Phosphatase Inhibitors and Methods of Use Thereof. US7504389.

Protein tyrosine phosphatase inhibitors and methods of use thereof

Blaskovich, Mark Arnold Thomas, Baughman, Ted, Little, Thomas, Patt, William, Qabar, Maher, Schultz, Lauri, Nagula, Gangadhar, Gage, Jennifer Lynn and Howbert, James Jeffry (2009). Protein tyrosine phosphatase inhibitors and methods of use thereof. US 07504389.

Protein tyrosine phosphatase inhibitors and methods of use thereof

Blaskovich, Mark A., Little, Thomas, Qabar, Maher, Schultz, Lauri, Gage, Jennifer Lynn, Hong, Feng, Baughman, Ted, Patt, William, Howbert, James Jeffry and Nagula, Gangadhar (2006). Protein tyrosine phosphatase inhibitors and methods of use thereof. US2006142250(A1).

beta-sheet mimetics and composition and methods relating thereto

Blaskovich, Mark A., Ogbu, Cyprian, O. and Kim, Hwa-Ok (2006). beta-sheet mimetics and composition and methods relating thereto. US7053214(B2).

Protein tyrosine pPhosphatase inhibitors and methods of use thereof

Blaskovich, Mark A., Baughman, Ted, Little, Thomas, Patt, William, Qabar, Maher, Schultz, Lauri, Hong, Feng, Nagula, Gangadhar, Gage, Jennifer Lynn and Howbert, James Jeffry (2006). Protein tyrosine pPhosphatase inhibitors and methods of use thereof. WO/2006/055525.

Beta-sheet mimetics and composition and methods relating thereto

Ogbu, Cyprian O., Kim, Hwa-Ok and Blaskovich, Mark, A. (2003). Beta-sheet mimetics and composition and methods relating thereto. WO/2003/068237.