Journal Article: Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies
Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2019) Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 126722. doi:10.1016/j.bmcl.2019.126722
Journal Article: R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma
Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019) R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 . doi:10.7554/elife.43026
Journal Article: Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes
Rao, Madhuri P., Gunaga, Shubha S., Zuegg, Johannes, Pamarthi, Rambabu and Ganesh, Madhu (2019) Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes. Organic and Biomolecular Chemistry, 17 42: 9390-9402. doi:10.1039/c9ob01429b
Antibacterial Potentiation Screening 1. Master Research Services Agreement - Statement of Work no.2
(2019) Global Antibiotic Research & Development Partnership Foundation
Antibacterial Screening 1. Master Research Services Agreement - Statement of Work no.1
(2019) Global Antibiotic Research & Development Partnership Foundation
Potent antibiotics against drug-resistant Tuberculosis
(2013–2015) NHMRC Development Grant
Development of novel anti-infective drugs targeting microbial proteins
(2015) Doctor Philosophy
Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2019) Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 126722. doi:10.1016/j.bmcl.2019.126722
Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019) R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 . doi:10.7554/elife.43026
Rao, Madhuri P., Gunaga, Shubha S., Zuegg, Johannes, Pamarthi, Rambabu and Ganesh, Madhu (2019) Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes. Organic and Biomolecular Chemistry, 17 42: 9390-9402. doi:10.1039/c9ob01429b
Fontaine, Frank R., Goodall, Stephen, Prokop, Jeremy W., Howard, Christopher B., Moustaqil, Mehdi, Kumble, Sumukh, Rasicci, Daniel T., Osborne, Geoffrey W., Gambin, Yann, Sierecki, Emma, Jones, Martina L., Zuegg, Johannes, Mahler, Stephen and Francois, Mathias (2018) Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10 4: 1-11. doi:10.1080/19420862.2018.1451288
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A, Paterson, David L. and Cooper, Matthew A. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 1: 22. doi:10.1038/s41467-017-02123-w
An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics
Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136 561-572. doi:10.1016/j.ejmech.2017.05.039
Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 2: FSO171. doi:10.4155/fsoa-2016-0093
Small-molecule inhibitors of the SOX18 transcription factor
Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017) Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 3: 346-359. doi:10.1016/j.chembiol.2017.01.003
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 . doi:10.7554/eLife.21221
Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016) Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 6: 442-450. doi:10.1021/acsinfecdis.6b00045
Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity
Mesleh, Michael F., Rajaratnam, Premraj, Conrad, Mary, Chandrasekaran, Vasu, Liu, Christopher M., Pandya, Bhaumik A., Hwang, You Seok, Rye, Peter T., Muldoon, Craig, Becker, Bernd, Zuegg, Johannes, Meutermans, Wim and Moy, Terence I. (2016) Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity. Chemical Biology and Drug Design, 87 2: 190-199. doi:10.1111/cbdd.12662
Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites
Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015) Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 96-102. doi:10.1016/j.ejmech.2015.06.019
Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity
Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 1: 1-11. doi:10.1038/ncomms8719
Helping chemists discover new antibiotics
Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015) Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 7: 285-287. doi:10.1021/acsinfecdis.5b00044
Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015) Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 6: 1511-1520. doi:10.1021/cb501032x
Phetsang, Wanida, Blaskovich, Mark A. T., Butler, Mark S., Huang, Johnny Xiao, Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M. and Cooper, Matthew A. (2014) An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants. Bioorganic and Medicinal Chemistry, 22 16: 4490-4498. doi:10.1016/j.bmc.2014.05.054
Imperfect coordination chemistry facilitates metal ion release in the Psa permease
Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 1: 35-41. doi:10.1038/nCHeMBIO.1382
Vancomycin: ligand recognition, dimerization and super-complex formation
Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2013) Vancomycin: ligand recognition, dimerization and super-complex formation. FEBS Journal, 280 5: 1294-1307. doi:10.1111/febs.12121
Jia, Z. G., O'Mara, M. L., Zuegg, J., Matthew Cooper and Mark, Alan (2013) Erratum: The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II (Biophysical Journal (2011) 101 (2684-2692)). Biophysical Journal, 104 2: 516-516. doi:10.1016/j.bpj.2012.12.031
Novoa, Alexandre, Van Dorpe, Sylvia, Wynendaele, Evelien, Spetea, Mariana, Bracke, Nathalie, Stalmans, Sofie, Betti, Cecilia, Chung, Nga N., Lemieux, Carole, Zuegg, Johannes, Cooper, Matthew A., Tourwe, Dirk, De Spiegeleer, Bart, Schiller, Peter W. and Ballet, Steven (2012) Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution. Journal of Medicinal Chemistry, 55 22: 9549-9561. doi:10.1021/jm3008079
Identification of antitubercular benzothiazinone compounds by ligand-based design
Karoli, Tomislav, Becker, Bernd, Zuegg, Johannes, Moellmann, Ute, Ramu, Soumya, Huang, Johnny X. and Cooper, Matthew A. (2012) Identification of antitubercular benzothiazinone compounds by ligand-based design. Journal of Medicinal Chemistry, 55 17: 7940-7944. doi:10.1021/jm3008882
Zuegg, Johannes and Cooper, Matthew A. (2012) Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening. Current Topics in Medicinal Chemistry, 12 14: 1500-1513. doi:10.2174/156802612802652466
Structure aided design of chimeric antibiotics
Karoli, Tomislav, Mamidyala, Sreeman K., Zuegg, Johannes, Fry, Scott R., Tee, Ernest H. L., Bradford, Tanya A., Madala, Praveen K., Huang, Johnny X., Ramu, Soumya, Butler, Mark S. and Cooper, Matthew A. (2012) Structure aided design of chimeric antibiotics. Bioorganic & Medicinal Chemistry Letters, 22 7: 2428-2433. doi:10.1016/j.bmcl.2012.02.019
Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2011) The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II. Biophysical Journal, 101 11: 2684-2692. doi:10.1016/j.bpj.2011.10.047
Abbenante, Giovanni, Becker, Bernd, Blanc, Sebastien, Clark, Chris, Condie, Glenn, Fraser, Graeme, Grathwohl, Matthias, Halliday, Judy, Henderson, Senka, Lam, Ann, Liu, Ligong, Mann, Maretta, Muldoon, Craig, Pearson, Andrew, Premraj, Rajaratnam, Ramsdale, Tracie, Rossetti, Tony, Schafer, Karl, Le Thanh, Giang, Tometzki, Gerald, Vari, Frank, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010) Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold. Journal of Medicinal Chemistry, 53 15: 5576-5586. doi:10.1021/jm1002777
A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds
Thanh, Giang Le, Abbenante, Giovanni, Adamson, George, Becker, Bernd, Clark, Chris, Condie, Glenn, Falzun, Tania, Grathwohl, Matthias, Gupta, Praveer, Hanson, Michael, Huynh, Ngoc, Katavic, Peter, Kuipers, Krystle, Lam, Ann, Liu, Ligong, Mann, Maretta, Mason, Jeff, McKeveney, Declan, Muldoon, Craig, Pearson, Andrew, Rajaratnam, Premraj, Ryan, Sarah, Tometzki, Gerry, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wilcox, Neil, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010) A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds. Journal of Organic Chemistry, 75 1: 197-203. doi:10.1021/jo9021919
Zuegg, Johannes and Meutermans, Wim (2007) Crystal structures of the PBP2 glycosyltransferase domain: For antibacterial drug design new opportunities. Chemmedchem, 2 10: 1403-1404. doi:10.1002/cmdc.200700114
A probabilistic measure for alignment-free sequence comparison
Pham T.D. and Zuegg J. (2004) A probabilistic measure for alignment-free sequence comparison. Bioinformatics, 20 18: 3455-3461. doi:10.1093/bioinformatics/bth426
Zuegg, J, Bliznyuk, AA and Gready, JE (2003) Comparison of electrostatic potential around proteins calculated from Amber and AM1 charges: application to mutants of prion protein. Molecular Physics, 101 15: 2437-2450. doi:10.1080/00268970310001592737
Molecular diversity through sugar scaffolds
Le, GT, Abbenante, G, Becker, B, Grathwohl, M, Halliday, J, Tometzki, G, Zuegg, J and Meutermans, W (2003) Molecular diversity through sugar scaffolds. Drug Discovery Today, 8 15: 701-709. doi:10.1016/S1359-6446(03)02751-X
Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor
Zuegg, J., Webb, D. C., Foster, P. S. and Casarotto, M. G. (2001) Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor. Immunology and Cell Biology, 79 4: 332-339. doi:10.1046/j.1440-1711.2001.01035.x
Identification of active-site residues of the pro-metastatic endoglycosidase heparanase
Hulett M.D., Hornby J.R., Ohms S.J., Zuegg J., Freeman C., Gready J.E. and Parish C.R. (2000) Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. Biochemistry, 39 51: 15659-15667. doi:10.1021/bi002080p
Zuegg, J and Gready, JE (2000) Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor. Glycobiology, 10 10: 959-974. doi:10.1093/glycob/10.10.959
Zuegg J. and Gready J.E. (1999) Molecular dynamics simulations of human prion protein: Importance of correct treatment of electrostatic interactions. Biochemistry, 38 42: 13862-13876. doi:10.1021/bi991469d
Zuegg, J, Gruber, K, Gugganig, M, Wagner, UG and Kratky, C (1999) Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Protein Science, 8 10: 1990-2000. doi:10.1110/ps.8.10.1990
Molecular reasons for lipase-sensitivity against acetaldehyde
Weber H.K., Zuegg J., Faber K. and Pleiss J. (1997) Molecular reasons for lipase-sensitivity against acetaldehyde. Journal of Molecular Catalysis - B Enzymatic, 3 1-4: 131-138. doi:10.1016/S1381-1177(96)00045-8
Zuegg J., Honig H., Schrag J.D. and Cygler M. (1997) Selectivity of lipases: Conformational analysis of suggested intermediates in ester hydrolysis of chiral primary and secondary alcohols. Journal of Molecular Catalysis - B Enzymatic, 3 1-4: 83-98. doi:10.1016/S1381-1177(96)00060-4
Petersen, EI, Zuegg, J, Ribbons, DW and Schwab, H (1996) Molecular cloning and homology modeling of protocatechuate 3,4-dioxygenase from Pseudomonas marginata. Microbiological Research, 151 4: 359-370.
Faber, K, Griengl, H, Honig, H and Zuegg, J (1994) On the Prediction of the Enantioselectivity of Candida-Rugosa Lipase by Comparative Molecular-Field Analysis. Biocatalysis, 9 1-4: 227-239. doi:10.3109/10242429408992122
Improved Computer-Simulation of Metathesis Reactions
Martl, MG, Zuegg, J and Hummel, K (1991) Improved Computer-Simulation of Metathesis Reactions. Journal of Molecular Catalysis, 65 1-2: 127-138. doi:10.1016/0304-5102(91)85089-K
Chia, C. S. Brian, Gong, Yujing, Bowie, John H., Zuegg, Johannes and Cooper, Matthew A. (2011) Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin and maculatin. Peptide Science, 96 2: 147-157. doi:10.1002/bip.21438
Carbohydrate-based combinatorial libraries for the discovery of new antibacterial agents
Adamson, G, Schafer, K, Louis, L, Tometzki, G, Le Thanh, G, Schliebs, D, West, M, Zuegg, J, Halliday, J and Meutermans, W (2001). Carbohydrate-based combinatorial libraries for the discovery of new antibacterial agents. In: Glycobiology. , , (902-902). .
Tometzki, Gerald B., Meutermans, Wim, Becker, Bernd, Zuegg, Johannes, Premraj, Rajaratnam, Muldoon, Craig, Mckeveney, Declan and Condie, Glenn (2008). Selective Inhibitors. US 20080009418.
Meutermans, Wim, Mckeveney, Declan, Zuegg, Johannes, Premraj, Rajaratnam, Muldoon, Craig and Le Thanh, Giang (2007). Monosaccharide compounds as antibacterial agents and their preparation and use in the treatment of diseases. .
Becker, Bernd, Condie, Glenn, Christopher, McKeveney, Declan, Meutermans, Wim, Muldoon, Craig, Premraj, Rajaratnam and Zuegg, Johannes (2006). Selective inhibitors. WO/2006/037159; PCT/AU2005/001510.
Biologically active compounds with with anti-angiogenic properties
Becker, Bernd, Condie, Glenn, Halliday, Judy, McKeveney, Declan, Meutermans, Wim, Muldoon, Craig, Premraj, Rajaratnam, Ramsdale, Tracie Elizabeth, Tometzki, Gerald and Zuegg, Johannes (2005). Biologically active compounds with with anti-angiogenic properties. WO/2005/097142; PCT/AU2005/000506.
Antibacterial Potentiation Screening 1. Master Research Services Agreement - Statement of Work no.2
(2019) Global Antibiotic Research & Development Partnership Foundation
Antibacterial Screening 1. Master Research Services Agreement - Statement of Work no.1
(2019) Global Antibiotic Research & Development Partnership Foundation
Potent antibiotics against drug-resistant Tuberculosis
(2013–2015) NHMRC Development Grant
Development of novel anti-infective drugs targeting microbial proteins
(2015) Doctor Philosophy — Associate Advisor
Other advisors: