The University of Queensland

Medicinal chemistry of a-hydroxy-b-amino acids

Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2011). Medicinal chemistry of a-hydroxy-b-amino acids. In Andrew B. Hughes (Ed.), Amino Acids, Peptides and Proteins in Organic Chemistry: Volume 4 - Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis (pp. 189-234) Weinheim, Germany: Wiley-VCH.

Tyrosinase inhibitors as potential antibacterial agents

Yuan, Ye, Jin, Wanli, Nazir, Yasir, Fercher, Christian, Thomas Blaskovich, Mark A., Cooper, Matthew A., Barnard, Ross T. and Ziora, Zyta M. (2019) Tyrosinase inhibitors as potential antibacterial agents. European Journal of Medicinal Chemistry, 111892. doi:10.1016/j.ejmech.2019.111892

Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies

Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2019) Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 126722. doi:10.1016/j.bmcl.2019.126722

Quinolone antibiotics

Pham, Thu D. M., Ziora, Zyta M. and Blaskovich, Mark A. T. (2019) Quinolone antibiotics. MedChemComm, 10 10: 1719-1739. doi:10.1039/c9md00120d

Antimicrobial silver in medicinal and consumer applications: a patent review of the past decade (2007–2017)

Sim, Wilson, Barnard, Ross, Blaskovich, M.A.T. and Ziora, Zyta (2018) Antimicrobial silver in medicinal and consumer applications: a patent review of the past decade (2007–2017). Antibiotics, 7 4: . doi:10.3390/antibiotics7040093

Silver bullets: a new lustre on an old antimicrobial agent

Möhler, Jasper S., Sim, Wilson, Blaskovich, Mark A. T., Cooper, Matthew A. and Ziora, Zyta M. (2018) Silver bullets: a new lustre on an old antimicrobial agent. Biotechnology Advances, 36 5: 1391-1411. doi:10.1016/j.biotechadv.2018.05.004

Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites

Naseri-Nosar, Mahdi and Ziora, Zyta Maria (2018) Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites. Carbohydrate Polymers, 189 379-398. doi:10.1016/j.carbpol.2018.02.003

Biological applications of Ru(II) polypyridyl complexes

Mital, Mariusz and Ziora, Zyta (2018) Biological applications of Ru(II) polypyridyl complexes. Coordination Chemistry Reviews, . doi:10.1016/j.ccr.2018.02.013

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A, Paterson, David L. and Cooper, Matthew A. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 1: 22. doi:10.1038/s41467-017-02123-w

Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies

Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017) Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167 134-141. doi:10.1016/j.jinorgbio.2016.11.028

Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016) Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 10: 2235-2241. doi:10.1016/j.bmc.2016.03.053

Platinum-based anticancer drugs encapsulated liposome and polymeric micelle formulation in clinical trials

Hang, Zhou, Cooper, Matthew A. and Ziora, Zyta M. (2016) Platinum-based anticancer drugs encapsulated liposome and polymeric micelle formulation in clinical trials. Biochemical Compounds, 4 . doi:10.7243/2052-9341-4-2

Ethanol concentration influences the mechanisms of wine tannin interactions with poly(l -proline) in model wine

McRae, Jacqui M., Ziora, Zyta M., Kassara, Stella, Cooper, Matthew A. and Smith, Paul A. (2015) Ethanol concentration influences the mechanisms of wine tannin interactions with poly(l -proline) in model wine. Journal of Agricultural and Food Chemistry, 63 17: 4345-4352. doi:10.1021/acs.jafc.5b00758

Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

Cheng, Mu, Ziora, Zyta M., Hansford, Karl A., Blaskovich, Mark A., Butler, Mark S. and Cooper, Matthew A. (2014) Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin. Organic and Biomolecular Chemistry, 12 16: 2568-2575. doi:10.1039/c3ob42428f

Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses

Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014) Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 37: 4743-4750. doi:10.1016/j.vaccine.2014.06.049

Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine

Ahmad Fuaad, Abdullah A. H., Jia, Zhongfan, Hartas, Jon, Ziora, Zyta M., Lin, I-Chun, Moyle, Peter M., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2014) Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine, 9 1: 35-43. doi:10.2217/NNM.13.7

ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2013) ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery. ChemInform, 44 43: no-no. doi:10.1002/chin.201343267

Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system

Simerska, Pavla, Ziora, Zyta Maria, Fagan, Vincent, Goodwin, Daryn, Edrous, Farrah and Toth, Istvan (2013) Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system. Drug Delivery and Translational Research, Online First 3: 1-10. doi:10.1007/s13346-013-0173-8

Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer

Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013) Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 8: 2798-2806. doi:10.1021/bm400626w

pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform

Skwarczynski, Mariusz, Kowapradit, Jariya, Ziora, Zyta Maria and Toth, Istvan (2013) pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform. Biochemical Compounds, 1 . doi:10.7243/2052-9341-1-2

Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes

Zaman, Mehfuz, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Ziora, Zyta M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2012) Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes. Journal of Medicinal Chemistry, 55 19: 8515-8523. doi:10.1021/jm301074n

Lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2012) Lipoamino acids as major components of absorption promoters in drug delivery. Current Topics in Medicinal Chemistry, 12 14: 1562-1580. doi:10.2174/156802612802652448

Lipopeptides for the fragment-based pharmaceutics design

Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2012) Lipopeptides for the fragment-based pharmaceutics design. International Journal of Organic Chemistry, 2 75-81. doi:10.4236/ijoc.2012.21013

Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011) Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 12: 1439-1444. doi:10.1016/j.carres.2011.03.019

Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers

Lin, I-Chun, Liang, Mingtao, Liu, Tzu-Yu, Ziora, Zyta M., Monteiro, Michael J. and Toth, Istvan (2011) Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers. Biomacromolecules, 12 4: 1339-1348. doi:10.1021/bm200116z

Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein

Skwarczynski, Mariusz, Ahmad Fuaad, Abdullah A. H., Rustanti, Lina, Ziora, Zyta M., Aqil, Mohammed, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2011) Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein. Drug Delivery Letters, 1 1: 2-8. doi:10.2174/2210304X11101010002

Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1

Kakizawa, Taeko, Hidaka, Koushi, Hamada, Daisuke, Yamaguchi, Ryoji, Uemura, Tsuyoshi, Kitamura, Hitomi, Tagad, Harichandra D., Hamada, Takashi, Ziora, Zyta, Hamada, Yoshio, Kimura, Tooru and Kiso, Yoshiaki (2010) Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1. Journal of Peptide Science, 16 6: 257-262. doi:10.1002/psc.1238

In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs

Bergeon, Julie A., Ziora, Zyta M., Abdelrahim, Adel S., Pernevi, Niklas, Moss, Anne R. and Toth, Istvan (2010) In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs. Journal of Pharmaceutical Sciences, 99 5: 2333-2342. doi:10.1002/jps.21999

Thymine, adenine and lipoamino acid based gene delivery systems

Skwarczynski, Mariusz, Ziora, Zyta M., Coles, Daniel J., Lin, I-Chun and Toth, Istvan (2010) Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications, 46 18: 3140-3142. doi:10.1039/b924371b

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

Abdelrahim, Adel. S., Ziora, Zyta M., Bergeon, Julie A., Moss, Anne R. and Toth, Istvan (2009) Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery. Tetrahedron, 65 45: 9436-9442. doi:10.1016/j.tet.2009.08.072

Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates

Ziora, Zyta and Kafarski, Pawel (2009) Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates. Phosphorus, Sulfur, and Silicon and the Related Elements, 184 4: 1047-1053. doi:10.1080/10426500902737356

Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines

Calas, Michele, Outtara, Mahama, Piquet, Giles, Ziora, Zyta, Bordat, Y., Ancelin, Marie L., Escale, Roger and Vial, Henri (2007) Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines. Journal of Medicinal Chemistry, 50 25: 6307-6315. doi:10.1021/jm0704752

Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes

Nagahama, Masahiro, Otsuka, Akiko, Oda, Masataka, Singh, Rajesh K., Ziora, Zyta M., Imagawa, Hiroshi, Nishizawa, Mugio and Sakurai, Jun (2007) Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768 11: 2940-2945. doi:10.1016/j.bbamem.2007.08.016

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid

Ziora, Zyta, Kasai, Soko, Hidaka, Koushi, Nagamine, Ayaka, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2007) Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid. Bioorganic and Medicinal Chemistry Letters, 17 6: 1629-1633. doi:10.1016/j.bmcl.2006.12.097

beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells

Hamada, Yoshio, Igawa, Naoto, Ikari, Hayato, Ziora, Zyta, Nguyen, Jeffrey-Tri, Yamani, Abdellah, Hidaka, Koushi, Kimura, Tooru, Saito, Kazuki, Hayashi, Yoshio, Ebina, Maiko, Ishiura, Shoichi and Kiso, Yoshiaki (2006) beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells. Bioorganic and Medicinal Chemistry Letters, 16 16: 4354-4359. doi:10.1016/j.bmcl.2006.05.046

Phenylthionorstatine as a transition-state mimic in BACE1 inhibitors

Ziora Zyta, Kasai Soko, Hidaka Koushi, Nagamine Ayaka, Kimura Tooru, Saito K., Hayashi Yoshio and Kiso Yoshiaki (2006) Phenylthionorstatine as a transition-state mimic in BACE1 inhibitors. Peptide Science, 2006 237-238.

Small-sized BACE1 inhibitors

Zyta, Ziora, Tooru, KImura and Yoshiaki, Kiso (2006) Small-sized BACE1 inhibitors. Drugs of the Future, 31 1: 53-63. doi:10.1358/dof.2006.031.01.957326

Conformational polymorphism of diethyl 1-(phthalylglycyloxy)-2-phthalylaminoethenephosphonate

Holband, J, Wojcik, G, Ziora, Z and Kafarski, P (2001) Conformational polymorphism of diethyl 1-(phthalylglycyloxy)-2-phthalylaminoethenephosphonate. Journal of Molecular Structure, 595 1-3: 167-174. doi:10.1016/S0022-2860(01)00521-X

Synthesis and spectroscopic characterization of protected N-phosphonomethylglycine dipeptides

Ziora, Zyta, Kafarski, Pawel, Holband, Jolanta and Wojcik, Grazyna (2001) Synthesis and spectroscopic characterization of protected N-phosphonomethylglycine dipeptides. Journal of Peptide Science, 7 9: 466-473. doi:10.1002/psc.340

H-1 NMR studies of rotational isomerism in phosphonic analogues of aspartic acid

Jedrzejczyk, D, Ziora, Z and Kafarski, P (2000) H-1 NMR studies of rotational isomerism in phosphonic analogues of aspartic acid. Magnetic Resonance in Chemistry, 38 5: 370-374.

Reactions of N-phthalylamino acid chlorides with trialkyl phosphites

Ziora, Zyta, Maly, Alina, Lejczak, Barbara, Kafarski, Pawel, Holband, Jolanta and W�jcik, Gra?yna (2000) Reactions of N-phthalylamino acid chlorides with trialkyl phosphites. Heteroatom Chemistry, 11 3: 232-239. doi:10.1002/(sici)1098-1071(2000)11:3<232::aid-hc12>3.0.co;2-u

Synthesis of triethyl N-formyl-N-phosphonomethylglycinate and diethyl N-formyl-N- phosphonomethylglycine and studies of their rotational conformers by dynamic NMR

Ziora, Z, Cierpicki, T, Grembecka, J and Kafarski, P (1999) Synthesis of triethyl N-formyl-N-phosphonomethylglycinate and diethyl N-formyl-N- phosphonomethylglycine and studies of their rotational conformers by dynamic NMR. Journal of Chemical Research, 2: 68-69A. doi:10.1039/a806474a

Synthesis of therapeutic vaccine against cervical cancer

Skwarczynski, Mariusz, Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J. and Toth, Istvan (2014). Synthesis of therapeutic vaccine against cervical cancer. In: Yuji Nishiuchi and Tadashi Teshima, Peptide Science 2013: Proceedings of the 4th Asia-Pacific International Peptide Symposium held in conjunction with the 50th Japanese Peptide Symposium. 4th Asia-Pacific International Peptide Symposium in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan, (65-68). 6-8 November 2013.

Nanoparticles-based peptide subunit vaccines against group A Streptococcus

Skwarczynski, M., Fuaad, A. A. H. A., Zaman, M., Jia, Z., Kowapradit, J., Rustanti, L., Ziora, Z. M., Monteiro, M. L. J., Batzloff, M. R., Goodc, M. F. and Toth, I. (2012). Nanoparticles-based peptide subunit vaccines against group A Streptococcus. In: 32nd European Peptide Symposium, Athens, Greece, (S53-S53). 2-7 September 2012. doi:10.1002/psc.2448

New glycopeptidic antibiotics to combat multidrug resistant pathogens

Gong, Y., Muldoon, C. A., Premraj, R., Ziora, Z. M., Bradford, T. A., Cheng, M., Ramu, S., Huang, J. X., Kavanagh, A., Pelingon, R., Lee, J. C., Wong, K., Butler, M. S., Blaskovich, M. A. and Cooper, M. A. (2012). New glycopeptidic antibiotics to combat multidrug resistant pathogens. In: 32nd European Peptide Symposium, Athens, Greece, (S65-S66). 2-7 September 2012. doi:10.1002/psc.2449

Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine

Ziora, Zyta, Shuto, Daisuke, Kasai, Soko, Liu, Ping, Hidaka, Koushi, Igawa, Nagai, Nagamine, Ayaka, Stochaj, Monika, Hamada, Takashi, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2006). Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine. In: Tateaki Wakamiya, Peptide Science 2005: Proceedings of the 42nd Japanese Peptide Symposium. 42nd Japanese Peptide Symposium, Osaka, Japan, (321-324). 27-29 October 2005.

A novel approach for the hydrophobic peptides synthesis and purification through O-N intramolecular acyl migration reaction

Sohma, Youhei, Sasaki, Masato, Ziora, Zyta, Takahashi, N., Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2004). A novel approach for the hydrophobic peptides synthesis and purification through O-N intramolecular acyl migration reaction. In: Michael Chorev, Tomi K. Sawyer and American Peptide Society, Peptide revolution: Genomics, proteomics & therapeutics: Proceedings of the eighteenth American Peptide Symposium. 18th American Peptide Symposium, Boston, MA, U.S.A., (67-68). 19-23 July 2003.