Dr Ben Ross

Senior Lecturer

School of Pharmacy
Faculty of Health and Behavioural Sciences
b.ross1@uq.edu.au
+61 7 334 61888

Overview

Dr Ben Ross is a chemist with interests in medicinal chemistry, computer-aided drug design, virtual screening, synthetic chemistry, enzyme inhibitors, ion channel modulators, antivirals, amyloid diseases, neurodegenerative diseases, and cancer.

Follow Dr Ben Ross and his team on Twitter: @RossChemLab ||| Google Scholar: Benjamin P. Ross ||| ResearcherID: A-9573-2012 ||| ORCID: 0000-0002-1899-8484 ||| Scopus Author ID:7401608823 ||| Group Web Page: www.drbenross.com

Research Interests

The main focus of Dr Ben Ross's research is the application of computer-aided drug design and synthetic chemistry to create new drug candidates for cancer, viral infections, and neurodegenerative diseases such as Alzheimer’s disease. His team's novel molecules are evaluated using a variety of biochemical, biophysical, and cell-based screening assays, as well as animal models of disease, both within their lab and in partnership with local and international collaborators. Consideration of drug-likeness is an integral part of the design process, since good ADMET properties are crucial for their molecules to reach the clinic.

Biography

Ben Ross graduated with a First-Class Honours Degree in Chemistry (1999) and then moved to the UQ School of Pharmacy where he gained a Doctorate in the field of Medicinal Chemistry (2004). He worked in the School of Molecular and Microbial Sciences as a Postdoctoral Research Fellow with Dr Ross McGeary for two years (2004-2006) during which he completed the synthesis of a variety of biologically useful molecules. In June 2006 Ben was appointed to a Lectureship within the UQ School of Pharmacy. In the first half of 2012 he was a Guest Researcher in the Department of Biochemistry and Structural Biology, Lund University, Sweden. In 2013 Ben was promoted to Senior Lecturer at UQ. A general theme of his research is medicinal chemistry, specifically the application of synthetic chemistry and molecular modeling to discover novel molecules with application as drugs or tools for research. Ben's team has published extensively in journals having a moderate-to-high impact factor in their specialised area of research (e.g. Journal of Medicinal Chemistry, Nanoscale, Food Chemistry).

Selected Primary Research Articles

Bifunctional Succinylated ε-Polylysine Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon. C.T.H. Nguyen, R.I. Webb, L.K. Lambert, E. Strounina, E.C. Lee, M.-O. Parat, M.A. McGuckin, A. Popat, P.J. Cabot, B.P. Ross*. ACS Applied Materials & Interfaces 2017, 9, 9470-9483. doi:10.1021/acsami.7b00411 (2016 JIF 7.5, Quartile 1)

Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening. S.N. Dighe, G.S. Deora, E. De la Mora, F. Nachon, S. Chan, M.-O. Parat, X. Brazzolotto*, B.P. Ross*. Journal of Medicinal Chemistry 2016, 59, 7683-7689. doi:10.1021/acs.jmedchem.6b00356 (Featured on the front cover of the journal: http://pubs.acs.org/toc/jmcmar/59/16) (2016 JIF 6.3, Quartile 1)

GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses. E.C. Lee, N. Davis-Poynter*, C.T.H. Nguyen, A.A. Peters, G.R. Monteith, E. Strouina, A. Popat*, B.P. Ross*. Nanoscale 2016, 8, 16192-16196. doi:10.1039/C6NR03878F (2016 JIF 7.4, Quartile 1)

Metal chelation, radical scavenging and inhibition of Aβ42 fibrillation by food constituents in relation to Alzheimer’s disease. S. Chan, S. Kantham, V.M. Rao, M.K. Palanivelu, H.L. Pham, P.N. Shaw, R.P. McGeary, B.P. Ross*. Food Chemistry 2016, 199, 185-194. doi:10.1016/j.foodchem.2015.11.118 (2016 JIF 4.5, Quartile 1)

"Click" Assembly of Glycoclusters and Discovery of a Trehalose Analogue that Retards Aβ40 Aggregation and Inhibits Aβ40-induced Neurotoxicity. H. Rajaram, M.K. Palanivelu, T.V. Arumugam, V.M. Rao, P.N. Shaw, R.P. McGeary, B.P. Ross*. Bioorganic & Medicinal Chemistry Letters 2014, 24, 4523-4528. doi:10.1016/j.bmcl.2014.07.077 (2014 JIF 2.4, Quartile 3)

Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres. A. Popat, B.P. Ross, J.Liu, S. Jambhrunkar, F. Kleitz*, S.Z. Qiao*. Angewandte Chemie International Edition 2012, 51, 12486-12489. doi:10.1002/anie.201206416 (2010 JIF 13.7, Quartile 1)

PhD vacancies - PhD opportunities

Australian and international students with backgrounds in chemistry, biochemistry, and pharmacy are encouraged to contact Dr Ben Ross to discuss possible Honours or PhD projects and scholarships.

Sources of funding include: UQ Scholarships; NHMRC Postgraduate Scholarships; Endeavour Scholarships and Fellowships; Malaysia Ministry of Higher Education (MOHE) Scholarships; Ministry of Education Saudi Arabia; and the China Scholarship Council (CSC), as well as many other funding schemes. Contact Dr Ben Ross via email to discuss the best strategy to obtain a scholarship.

Teaching and Service Activities

Dr Ben Ross is the Research Higher Degrees Coordinator for the School of Pharmacy, and an Academic Advisor for Year 2 of the BPharm(Hons) program. He also coordinates and teaches within the following undergraduate BPharm(Hons) courses:

PHRM2021 Dosage Form Design A1;

PHRM2022 Dosage Form Design A2;

PHRM2040 Drug Discovery A1;

PHRM2041 Drug Discovery A2 - Course Coordinator;

PHRM3021 Dosage Form Design B1.

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Honours), The University of Queensland

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • (2017) Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Australian and international students with backgrounds in chemistry, biochemistry, and pharmacy are encouraged to contact Dr Ben Ross to discuss possible Honours or PhD projects and scholarships.

    Sources of funding include: UQ Scholarships; NHMRC Postgraduate Scholarships; Endeavour Scholarships and Fellowships; Malaysia Ministry of Higher Education (MOHE) Scholarships; Ministry of Education Saudi Arabia; and the China Scholarship Council (CSC), as well as many other funding schemes. Contact Dr Ben Ross via email to discuss the best strategy to obtain a scholarship.

View all Available Projects

Publications

Journal Article

Conference Publication

  • Ross, Benjamin P., Palanivelu, Manoj, Arumugam, Thiruma V, McGeary, Ross P. and Shaw, Paul N. (2012). Synthesis and effect of dendrimers on the aggregation and neurotoxicity of Alzheimer's amyloid-beta peptide. In: Atta-ur-Rahman, David Fairlie, William J. Hoekstra and Bernard Pirotte, Abstracts: 4th International Conference on Drug Discovery and Therapy. 4th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, (186-186). 12-15 February 2012.

  • Rao, VM, Pham, HL, Shaw, PN, McGeary, RP and Ross, BP (2011). Effect of pH, salts and glycosaminoglycans on the fibrillization of amyloid beta protein A beta 1-28. In: Abstracts of Papers of the American Chemical Society. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim Ca, (). Mar 27-31, 2011.

  • Rao, Venkatesan Moorthy, Pham, Hoang, Shaw, Paul N. and Ross, Benjamin P. (2010). Effect of extrinsic elements on the fibrillisation of amyloid beta protein ab(1-28). In: 62nd Indian Pharmaceutical Congress 2010, Manipal, India, (). 17-19 December 2010.

  • Palanivelu, Manoj Kumar, McGeary, Ross P., Shaw, Paul N. and Ross, Benjamin P. (2010). Facile synthesis of surface modified poly-(L-lysine)dendrimers by solid phase peptide synthesis. In: L. Emmerton, A. Peters, D. Ross and B. Ross, Proceedings of the Australasian Pharmaceutical Science Association Annual Conference. Australasian Pharmaceutical Science Association Annual Conference, Brisbane, Qld, Australia, (). 6-9 December 2010.

  • Skoczylas, Malgorzata, Lambert, Lynette Kay, Davies, Nigel M. and Ross, Benjamin P. (2010). Measurement of the association of diflunisal with cyclodextrin-crosslinked poly(acrylic acid) via 19F NMR. In: L. Emmerton, A. Peters, D. Ross and B. Ross, Proceedings of the Australasian Pharmaceutical Science Association Annual Conference. Australasian Pharmaceutical Science Association Annual Conference, Brisbane, Qld, Australia, (120-120). 6-9 December, 2010.

  • Rao, Venkatesan Moorthy, Shaw, Paul N., McGeary, Ross P. and Ross, Benjamin P. (2010). Optimisation of Alzheimer's amyloid beta (1-28) fibrillisation for Thioflavin T assay. In: L. Emmerton, A. Peters, D. Ross and B. Ross, Proceedings of the Australasian Pharmaceutical Science Association Annual Conference. Australasian Pharmaceutical Science Association Annual Conference, Brisbane, Qld, Australia, (). 6-9 December 2010.

  • Rajaram, Hemalatha, Marcano, Kara L, McGeary, Ross P., Shaw, Paul N. and Ross, Benjamin P. (2010). Optimisation of glycopeptide dendrimer synthesis on solid phase. In: L. Emmerton, A. Peters, D. Ross and B. Ross, Proceedings of the Australasian Pharmaceutical Science Association Annual Conference. Australasian Pharmaceutical Science Association Annual Conference, Brisbane, Qld, Australia, (). 6-9 December, 2010.

  • Ramli, S, Ross, BP and Gentle, IR (2009). Formulation and physical characterization of microemulsions containing isotretinoin. In: ICBPE 2009 : 2nd International Conference on Biomedical and Pharmaceutical Engineering: Conference proceedings. International Conference on Biomedical and Pharmaceutical Engineering, Singapore, Republic of Singapore, (129-135). 2-4 December 2009. doi:10.1109/ICBPE.2009.5384088

  • Rudiyansyah, Suciati, Lambert, L.K., Ross, B.P. and Garson, M.J. (2009). New chemistry from South East Asian medicinal plants. In: Abstracts of the 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Geneva, Switzerland, (878-878). 16-20 August 2009. doi:10.1055/s-0029-1234236

  • Suciati, Garson, M.J. and Ross, B.P. (2009). Secondary metabolites and anti-acetylcholinesterase activity of Pandanus amaryllifolius and Pandanus conoideus. In: 2nd Collaborative Conference Universitas Airlangga-Universiti Sains Malaysia, Surabaya, Indonesia, (). 10-11 February 2009.

  • Thompson, Justin, Giuseppin, Marco, Palanivelu, Manoj, Harris, Sean and Ross, Benjamin P. (2009). Synthesis and IAM chromatography of prodrug analogues of TRH. In: Australasian Pharmaceutical Science Association Annual Conference, Hobart, Tasmania, Australia, (). 9-11 December 2009.

  • Rudiyansyah, Suciati, Garson, Mary J. and Ross, B. P. (2008). Chemical diversity from indigenous Indonesian plants: New metabolites from Durio spp. and from Fagraea spp.. In: Kurt Hostettmann, W. Dyatmiko, B. Prajogo, A. Marston and J-L. Wolffender, Biology, Chemistry, Pharmacology and Clinical Studies of Asian Plants: Proceedings of the IOCD International Symposium. IOCD International Symposium: Biology, Chemistry, Pharmacology and Clinical Studies of Asian Plants, Surabaya, Indonesia, (1-11). 9-11 April, 2007.

  • Garson, M.J., Salim, A.A., . Rudiyansyah, Suciati and Ross, B.P. (2008). Chemical studies on Indonesian medicinal plants. In: International Organization for Chemical Sciences in Development Meeting, Botswana, (). February, 2008.

  • Garson, M. J., Rudiyansyah, Suciati, Lambert, L. K. and Ross, B. P. (2008). Stereochemistry and medicinal natural products: Pitfalls and progress. In: Pure and Applied Chemistry. International Conference on Biodiversity and Natural Products (ICOB-6 & ISCNP-26), Charlottetown, Prince Edward Island, Canada, 13–18 July 2008. (IUPAC) International Conference on Biodiversity and Natural Products (ICOB-6 and ISCNP-26): 26th International Symposium on the Chemistry of Natural Products & 6th International Conference on Biodiversity, Charlottetown, Canada, (). 13-18 July 2008.

  • Garson, M.J., Rudiyansyah, Rands-Trevor, K., Suciati, Suciati, Yong, K.W.L., Lambert, L.K., Ross, B.P. and Blanchfield, J.T. (2008). Stereochemistry and medicinal natural products: Pitfalls and progress. In: Advances in Heterocyclic Chemistry and Medicinal Chemistry. The Halpern Symposium, Wollongong, Australia, (). July, 2008.

  • Garson, M.J., Rudiyansyah, Suciati, Lambert, L.K. and Ross, B.P. (2008). Stereochemistry and medicinal natural products: pitfalls and progress. In: RACI National Organic Chemistry Conference, Hobart, Australia, (). Dec, 2008.

  • Garson, M.J., Rudiyansyah, Suciati, Suciati, Lambert, L.K. and Ross, B.P. (2008). Stereochemistry and medicinal natural products: pitfalls and progress. In: Natural Product Group NSW Branch RACI Annual One-Day Meeting, Lismore, Australia, (). Oct, 2008.

  • Wessling, S., Ross, B P, Blanchfield, J T and Toth, I (2006). Caco-2 cell permeability and stability assays of two d-glycopyranuronanamide conjugates of thyrotropic releasing hormone. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 24 Nov 2006.

  • Toth, I., Blanchfield, J. T., McGeary, R. P., Ross, B. P. and Chan, Y. (2002). Liposaccharides in drug delivery. In: XX1st International Carbohydrate Symposium Program. XX1st International Carbohydrate Symposium, Cairns, (442-442). 7-12 July 2002.

  • Wong, A. K., Ross, B. P., Artusson, P., Lazorova, L. and Toth, I. (2001). Determination of the transport across Caco-2 cell monolayers of compounds varying in lipophilicity using LC-MS. In: J. Martinez and J-A. Fehrentz, Proceedings of the 26th European Peptide Conference. 26th European Peptide Conference, Montpellier, France, (321-322). 10th - 15th September, 2000.

  • Wong, A. K., Ross, B. P., Jones, A., Artursson, P., Lazorova, L. and Toth, I. (2000). Determination of the transport across CACO-2 cell monolayers of compounds varying in lipophilicity using LC-MS. In: M. Smith, R. Prankerd and S. Duffull, Proceedings of the Australasian Pharmaceutical Science Association. APSA 2000 Annual Conference, Newcastle, (). 6-8 December, 2000.

  • Wong, A. K., Ross, B. P., Jones, A., Artursson, P., Lazorova, L. and Toth, I. (2000). Measurement of the transport across CaCo -2 cell monolayers of compounds varying in lipophilicity using LC-MS. In: Proceedings of The First Brisbane Biological & Organic Chemistry Symposium. The First Brisbane Biological & Organic Chemistry Symposium, Griffith University, (16). 27 Nov. 2000.

Edited Outputs

Other Outputs

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Australian and international students with backgrounds in chemistry, biochemistry, and pharmacy are encouraged to contact Dr Ben Ross to discuss possible Honours or PhD projects and scholarships.

    Sources of funding include: UQ Scholarships; NHMRC Postgraduate Scholarships; Endeavour Scholarships and Fellowships; Malaysia Ministry of Higher Education (MOHE) Scholarships; Ministry of Education Saudi Arabia; and the China Scholarship Council (CSC), as well as many other funding schemes. Contact Dr Ben Ross via email to discuss the best strategy to obtain a scholarship.