The University of Queensland

Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction

Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293

From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions

Chhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin

Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319

Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide

Wu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c

Anticoagulant heparin mimetics via RAFT Polymerization

Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688

Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions

He, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328

Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis

Ferro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h

An enzymatic activity assay for heparanase that is useful for evaluating clinically relevant inhibitors and studying kinetics

Hammond, Edward and Ferro, Vito (2023). An enzymatic activity assay for heparanase that is useful for evaluating clinically relevant inhibitors and studying kinetics. Methods in molecular biology. (pp. 227-238) edited by Nikos K. Karamanos. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-2946-8_16

Mucopolysaccharidosis type II (Hunter syndrome): clinical and biochemical aspects of the disease and approaches to its diagnosis and treatment

Mohamed, Shifaza, He, Qi Qi, Singh, Arti A. and Ferro, Vito (2020). Mucopolysaccharidosis type II (Hunter syndrome): clinical and biochemical aspects of the disease and approaches to its diagnosis and treatment. Advances in carbohydrate chemistry and biochemistry. (pp. 71-118) edited by David C. Baker. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.accb.2019.09.001

Synthetic approaches to l-Iduronic Acid and l-Idose: key building blocks for the preparation of glycosaminoglycan oligosaccharides

Mohamed, Shifaza and Ferro, Vito (2015). Synthetic approaches to l-Iduronic Acid and l-Idose: key building blocks for the preparation of glycosaminoglycan oligosaccharides. Advances in carbohydrate chemistry and biochemistry. (pp. 21-61) edited by David C. Baker and Derek Horton. Waltham, MA, United States: Academic Press. doi: 10.1016/bs.accb.2015.07.001

Heparanase as a Target for Anticancer Therapeutics: New Developments and Future Prospects

Hammond, E., Bytheway, I. and Ferro, V. (2006). Heparanase as a Target for Anticancer Therapeutics: New Developments and Future Prospects. New Developments in Therapeutic Glycomics. (pp. 251-282) edited by Maryse Delehedde and Hugues Lortat-Jacob. Trivandrum, India: Research Signpost.

Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py

Mutch, Alexandra L., Ferro, Vito, A, Anitha and Grøndahl, Lisbeth (2024). Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py. Carbohydrate Polymers, 324 121488, 1-9. doi: 10.1016/j.carbpol.2023.121488

Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screening

Li, Binjie, Zhang, Tianji, Cao, Hui, Ferro, Vito, Li, Jinping and Yu, Mingjia (2023). Identification of a pentasaccharide lead compound with high affinity to the SARS-CoV-2 spike protein via in silico screening. International Journal of Molecular Sciences, 24 (22) 16115, 1-16. doi: 10.3390/ijms242216115

C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivity

See, Nicholas W., Pierens, Gregory K., Krenske, Elizabeth and Ferro, Vito (2023). C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivity. Synthesis. doi: 10.1055/a-2149-4586

Siderophore conjugates to combat antibiotic-resistant bacteria

Rayner, Beth, Verderosa, Anthony D., Ferro, Vito and Blaskovich, Mark A. T. (2023). Siderophore conjugates to combat antibiotic-resistant bacteria. RSC Medicinal Chemistry, 14 (5), 800-822. doi: 10.1039/d2md00465h

Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase

Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619

A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome

Hemsley, Kim M., Beard, Helen, Doherty, Gareth G., Mubarokah, Siti, Nazri, Nazzmer and Ferro, Vito (2023). A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome. Molecular Genetics and Metabolism, 138 (2) 107145, 59-59. doi: 10.1016/j.ymgme.2022.107145

Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD

Boittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158

Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**

Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco and Elli, Stefano (2022). Evidence for multiple binding modes in the initial contact between SARS‐CoV‐2 spike S1 protein and cell surface glycans**. Chemistry – A European Journal, 29 (1) e202202599, e202202599. doi: 10.1002/chem.202202599

An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosides

See, Nicholas W, Xu, Xiaowen and Ferro, Vito (2022). An improved protocol for the stereoselective synthesis of β-D-glycosyl fluorides from 2-O-acyl thioglycosides. The Journal of Organic Chemistry, 87 (21), 14230-14240. doi: 10.1021/acs.joc.2c01748

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

Lo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413

Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction

Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293

Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin

Gockel, Lukas M., Nekipelov, Katrin, Ferro, Vito, Bendas, Gerd and Schlesinger, Martin (2022). Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin. Cancer Immunology, Immunotherapy, 71 (10), 2523-2533. doi: 10.1007/s00262-022-03186-5

Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activity

Al‐Buthabhak, Hawraa S., Falasca, Valerio, Yu, Yu, Sobolev, Alexandre N., Skelton, Brian W., Moggach, Stephen A., Ferro, Vito, Al‐Salami, Hani and Baker, Murray V. (2022). Au‐NHC complexes with thiocarboxylate ligands: synthesis, structure, stability, thiol exchange and in vitro anti‐cancer activity. Applied Organometallic Chemistry. doi: 10.1002/aoc.6645

Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections

Chhabra, Mohit, Wilson, Jennifer C., Wu, Liang, Davies, Gideon J., Gandhi, Neha S. and Ferro, Vito (2022). Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections. Chemistry – A European Journal, 28 (11) e202104222, e202104222. doi: 10.1002/chem.202104222

Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate

Chhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453

From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions

Chhabra, Mohit, Doherty, Gareth G., See, Nicholas W., Gandhi, Neha S. and Ferro, Vito (2021). From cancer to COVID‐19: a perspective on targeting heparan sulfate‐protein interactions. The Chemical Record, 21 (11) tcr.202100125, 3087-3101. doi: 10.1002/tcr.202100125

Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599)

Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2021). Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo (Front. Cell Dev. Biol., (2020), 8, 599, 10.3389/fcell.2020.00599). Frontiers in Cell and Developmental Biology, 9 678589. doi: 10.3389/fcell.2021.678589

A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose

See, Nicholas W., Wimmer, Norbert, Krenske, Elizabeth H. and Ferro, Vito (2021). A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose. European Journal of Organic Chemistry, 2021 (10), 1575-1584. doi: 10.1002/ejoc.202100042

Inhibition of tumor-host cell interactions using synthetic heparin mimetics

Gockel, Lukas M., Heyes, Martin, Li, Honglian, Al Nahain, Abdullah, Gorzelanny, Christian, Schlesinger, Martin, Holdenrieder, Stefan, Li, Jin-Ping, Ferro, Vito and Bendas, Gerd (2021). Inhibition of tumor-host cell interactions using synthetic heparin mimetics. ACS Applied Materials and Interfaces, 13 (6), 7080-7093. doi: 10.1021/acsami.0c20744

Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R. and Gandhi, Neha S. (2021). Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Computational and Structural Biotechnology Journal, 19, 2806-2818. doi: 10.1016/j.csbj.2021.05.002

GlycoTorch Vina: docking designed and tested for glycosaminoglycans

Boittier, Eric D., Burns, Jed M., Gandhi, Neha S. and Ferro, Vito (2020). GlycoTorch Vina: docking designed and tested for glycosaminoglycans. Journal of Chemical Information and Modeling, 60 (12), 6328-6343. doi: 10.1021/acs.jcim.0c00373

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin

Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thrombosis and Haemostasis, 120 (12), 1700-1715. doi: 10.1055/s-0040-1721319

Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity

Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2020). Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity. Macromolecular Bioscience, 20 (9) 2000110, e2000110. doi: 10.1002/mabi.202000110

Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo

Huang, Xuan, Reye, Gina, Momot, Konstantin I., Blick, Tony, Lloyd, Thomas, Tilley, Wayne D., Hickey, Theresa E., Snell, Cameron E., Okolicsanyi, Rachel K., Haupt, Larisa M., Ferro, Vito, Thompson, Erik W. and Hugo, Honor J. (2020). Heparanase promotes syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo. Frontiers in Cell and Developmental Biology, 8 599, 599. doi: 10.3389/fcell.2020.00599

PI-88 and related heparan sulfate mimetics

Chhabra, Mohit and Ferro, Vito (2020). PI-88 and related heparan sulfate mimetics. Advances in Experimental Medicine and Biology, 1221, 473-491. doi: 10.1007/978-3-030-34521-1_19

Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide

Wu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c

Synthesis of cholesterol glycoconjugates for targeted liposomal drug delivery

Nguyen, Huong, Pan, Yuchen, Nahain, Abdullah Al, Clarke, Daniel, McMillan, Nigel A. and Ferro, Vito (2020). Synthesis of cholesterol glycoconjugates for targeted liposomal drug delivery. Trends in Carbohydrate Research, 12 (3), 1-9.

Anticoagulant heparin mimetics via RAFT Polymerization

Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2019). Anticoagulant heparin mimetics via RAFT Polymerization. Biomacromolecules, 21 (2), 1009-1021. doi: 10.1021/acs.biomac.9b01688

Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545

Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004

Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions

He, Qi Qi, Trim, Paul James, Lau, Adeline A., King, Barbara M., Hopwood, John J., Hemsley, Kim M., Snel, Marten Francis and Ferro, Vito (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10 (8) acschemneuro.9b00328, 3847-3858. doi: 10.1021/acschemneuro.9b00328

PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice

Supramaniam, Aroon, Bielefeldt-Ohmann, Helle, Rudd, Penny A., Webster, Julie, Ferro, Vito and Herrero, Lara J. (2019). PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice. PLoS ONE, 14 (6) e0217998, e0217998. doi: 10.1371/journal.pone.0217998

In vitro enzymatic digestibility of glutaraldehyde-crosslinked chitosan nanoparticles in lysozyme solution and their applicability in pulmonary drug delivery

Islam, Nazrul, Wang, Hui, Maqbool, Faheem and Ferro, Vito (2019). In vitro enzymatic digestibility of glutaraldehyde-crosslinked chitosan nanoparticles in lysozyme solution and their applicability in pulmonary drug delivery. Molecules, 24 (7) 1271, 1271. doi: 10.3390/molecules24071271

Cross-species analysis of glycosaminoglycan binding proteins reveals some animal models are “more equal” than others

Boittier, Eric, Gandhi, Neha, Ferro, Vito and Coombe, Deirdre (2019). Cross-species analysis of glycosaminoglycan binding proteins reveals some animal models are “more equal” than others. Molecules, 24 (5) 924, 924. doi: 10.3390/molecules24050924

Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate

He, Qi Qi, Trim, Paul J., Snel, Marten F., Hopwood, John J. and Ferro, Vito (2018). Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate. Organic & Biomolecular Chemistry, 16 (45), 8791-8803. doi: 10.1039/c8ob02225a

The development of assays for heparanase enzymatic activity: towards a gold standard

Chhabra, Mohit and Ferro, Vito (2018). The development of assays for heparanase enzymatic activity: towards a gold standard. Molecules, 23 (11) 23112971, 2971. doi: 10.3390/molecules23112971

Applications of ion mobility-mass spectrometry in carbohydrate chemistry and glycobiology

Mu, Yuqing, Schulz, Benjamin L. and Ferro, Vito (2018). Applications of ion mobility-mass spectrometry in carbohydrate chemistry and glycobiology. Molecules, 23 (10) 2557, 2557. doi: 10.3390/molecules23102557

Structural and conformational studies of the heparan sulfate mimetic PI-88

Elli, Stefano, Stancanelli, Eduardo, Handley, Paul N, Carroll, Anthony, Urso, Elena, Guerrini, Marco and Ferro, Vito (2018). Structural and conformational studies of the heparan sulfate mimetic PI-88. Glycobiology, 28 (10), 731-740. doi: 10.1093/glycob/cwy068

Glycosylations of simple acceptors with 2-O-acyl L-idose or L-iduronic acid donors reveal only a minor role for neighbouring-group participation

Mohamed, Shifaza, He, Qi Qi, Lepage, Romain J., Krenske, Elizabeth H. and Ferro, Vito (2018). Glycosylations of simple acceptors with 2-O-acyl L-idose or L-iduronic acid donors reveal only a minor role for neighbouring-group participation. European Journal of Organic Chemistry, 2018 (19), 2214-2227. doi: 10.1002/ejoc.201800318

Heparin mimetics with anticoagulant activity

Nahain, Abdullah Al, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John and Ferro, Vito (2018). Heparin mimetics with anticoagulant activity. Medicinal Research Reviews, 38 (5), 1582-1613. doi: 10.1002/med.21489

Prophylactic anti-heparanase activity by PG545 is anti-viraland protects against Ross River virus disease in mice

Supramaniam, Aroon, Lui, Xiang, Ferro, Vito and Herrero, Lara (2018). Prophylactic anti-heparanase activity by PG545 is anti-viraland protects against Ross River virus disease in mice. Antimicrobial Agents and Chemotherapy, 62 (4) e01959-17, e01959-17. doi: 10.1128/AAC.01959-17

New structural insights into the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y2448 phosphomannan

Handley, Paul N., Carroll, Anthony and Ferro, Vito (2017). New structural insights into the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y2448 phosphomannan. Carbohydrate Research, 446-447, 68-75. doi: 10.1016/j.carres.2017.05.008

Carbohydrate–N-heterocyclic carbene metal complexes: synthesis, catalysis and biological studies

Zhao, Weihao, Ferro, Vito and Baker, Murray V. (2017). Carbohydrate–N-heterocyclic carbene metal complexes: synthesis, catalysis and biological studies. Coordination Chemistry Reviews, 339, 1-16. doi: 10.1016/j.ccr.2017.03.005

Glycosaminoglycans and their mimetics

Ferro, Vito (2017). Glycosaminoglycans and their mimetics. Molecules, 22 (1) 20, 20. doi: 10.3390/molecules22010020

Recent advances in chitosan-based nanoparticulate pulmonary drug delivery

Islam, Nazrul and Ferro, Vito (2016). Recent advances in chitosan-based nanoparticulate pulmonary drug delivery. Nanoscale, 8 (30), 14341-14358. doi: 10.1039/c6nr03256g

Effects of chemical conjugation of L‑leucine to chitosan on dispersibility and controlled release of drug from a nanoparticulate dry powder inhaler formulation

Muhsin, Mohammad D. A., George, Graeme, Beagley, Kenneth, Ferro, Vito, Wang, Hui and Islam, Nazrul (2016). Effects of chemical conjugation of L‑leucine to chitosan on dispersibility and controlled release of drug from a nanoparticulate dry powder inhaler formulation. Molecular Pharmaceutics, 13 (5), 1455-1466. doi: 10.1021/acs.molpharmaceut.5b00859

The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations

Mohamed, Shifaza, Krenske, Elizabeth H. and Ferro, Vito (2016). The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations. Organic and Biomolecular Chemistry, 14 (10), 2950-2960. doi: 10.1039/C6OB00283H

Meet our editorial board member

Ferro, Vito (2016). Meet our editorial board member. Current Medicinal Chemistry, 23 (1), 1. doi: 10.2174/092986732301151230160254

Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery

Nguyen, Huong, Katavic, Peter, Bashah, Nur Atikah Halim and Ferro, Vito (2016). Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery. ChemistrySelect, 1 (1), 31-35. doi: 10.1002/slct.201600007

The Tortoise and the hare: evolving regulatory landscapes for biosimilars

Konara, Chamindika S., Barnard, Ross T., Hine, Damian, Siegel, Evan and Ferro, Vito (2015). The Tortoise and the hare: evolving regulatory landscapes for biosimilars. Trends in Biotechnology, 34 (1), 70-83. doi: 10.1016/j.tibtech.2015.10.009

Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk.

Shawky, Michael S., Ricciardelli, Carmela, Lord, Megan, Whitelock, John, Ferro, Vito, Britt, Kara and Thompson, Erik W. (2015). Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk.. Journal of Mammary Gland Biology and Neoplasia, 20 (3-4), 121-131. doi: 10.1007/s10911-015-9346-z

Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library

He, Q. Q., Wimmer, N., Verquin, G., Meutermans, W. and Ferro, V. (2015). Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library. Organic and Biomolecular Chemistry, 13 (13), 4070-4079. doi: 10.1039/C5OB00122F

Meet the editorial board

Ferro, Vito (2015). Meet the editorial board. Current Medicinal Chemistry, 22 (4), 405-405. doi: 10.2174/092986732204141226144632

Synthesis and toxicological evaluation of a chitosan-l-leucine conjugate for pulmonary drug delivery applications

Muhsin, Mohammad D. A., George, Graeme, Beagley, Kenneth, Ferro, Vito, Armitage, Charles and Islam, Nazrul (2014). Synthesis and toxicological evaluation of a chitosan-l-leucine conjugate for pulmonary drug delivery applications. Biomacromolecules, 15 (10), 3596-3607. doi: 10.1021/bm5008635

Attempted synthesis of the imidazylate of an α-hydroxylactone results in unexpected chlorination: Synthesis and X-ray crystal structure of 5-Chloro-5-deoxy-1,2- O -isopropylidene-β- l -idurono-6,3-lactone

Mohamed, Shifaza, Bernhardt, Paul V. and Ferro, Vito (2014). Attempted synthesis of the imidazylate of an α-hydroxylactone results in unexpected chlorination: Synthesis and X-ray crystal structure of 5-Chloro-5-deoxy-1,2- O -isopropylidene-β- l -idurono-6,3-lactone. Journal of Carbohydrate Chemistry, 33 (4), 197-205. doi: 10.1080/07328303.2014.907908

Low-molecular-weight heparin biosimilars: potential implications for clinical practice

Nandurkar, H., Chong, B., Salem, H., Gallus, A., Ferro, V. and McKinnon, R. (2014). Low-molecular-weight heparin biosimilars: potential implications for clinical practice. Internal Medicine Journal, 44 (5), 497-500. doi: 10.1111/imj.12417

1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

Wilson, Jennifer C., Laloo, Andrew Elohim, Singh, Sanjesh and Ferro, Vito (2014). 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase. Biochemical and Biophysical Research Communications, 443 (1), 185-188. doi: 10.1016/j.bbrc.2013.11.079

Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues

Katavic, Peter L., Yong, Ken W. L., Herring, Joel N., Deseo, Myrna A., Blanchfield, Joanne T., Ferro, Vito and Garson, Mary J. (2013). Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues. Tetrahedron, 69 (37), 8074-8079. doi: 10.1016/j.tet.2013.06.079

Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

Ferro, Vito (2013). Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses. Expert Opinion on Therapeutic Targets, 17 (8), 965-975. doi: 10.1517/14728222.2013.811491

MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells

Plummer, Prue N., Freeman, Ruth, Taft, Ryan, Vider, Jelena, Sax, Michael, Umer, Brittany, Gao, Dingcheng, Johns, Christopher A., Mattick, John S., Wilton, Stephen D., Ferro, Vito, McMillan, Nigel A, Swarbrick, Alex, Mittal, Vivek and Mellick, Albert S. (2013). MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer Research, 73 (1), 341-352. doi: 10.1158/0008-5472.CAN-12-0271

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors

Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012). A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 (19), 6190-6194. doi: 10.1016/j.bmcl.2012.08.001

Synthesis of disaccharides containing 6-Deoxy-α-L-talose as potential heparan sulfate mimetics

Fairweather, Jon K., Liu, Ligong, Karoli, Tomislav and Ferro, Vito (2012). Synthesis of disaccharides containing 6-Deoxy-α-L-talose as potential heparan sulfate mimetics. Molecules, 17 (8), 9790-9802. doi: 10.3390/molecules17089790

Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template

Liu, Ligong, Li, Caiping, Cochran, Siska, Jimmink, Shane and Ferro, Vito (2012). Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template. ChemMedChem, 7 (7), 1267-1275. doi: 10.1002/cmdc.201200151

Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis

Ferro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h

Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate

Lundin, Anna, Bergstrom, Tomas, Andrighetti-Fröhner, Carla R., Bendrioua, Loubna, Ferro, Vito and Trybala, Edward (2012). Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate. Antiviral Research, 93 (1), 101-109. doi: 10.1016/j.antiviral.2011.11.002

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011). PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 (5), 635-642. doi: 10.1038/bjc.2011.11

Synthesis of simple heparanase substrates

Pearson, Andrew G., Kiefel, Milton J., Ferro, Vito and von Itzstein, Mark (2011). Synthesis of simple heparanase substrates. Organic and Biomolecular Chemistry, 9 (12), 4614-4625. doi: 10.1039/c1ob05165b

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1

Said, J, Trybala, E, Andersson, E, Johnstone, K, Liu, LG, Wimmer, N, Ferro, V and Bergstrom, T (2010). Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. Antiviral Research, 86 (3), 286-295. doi: 10.1016/j.antiviral.2010.03.011

The PG500 series: Novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V. and Bytheway, I. (2010). The PG500 series: Novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy. Investigational New Drugs, 28 (3), 276-283. doi: 10.1007/s10637-009-9245-5

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

Ekblad, M, Adamiak, B, Bergstrom, T, Johnstone, KD, Karoli, T, Liu, LG, Ferro, V and Trybala, E (2010). A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus. Antiviral Research, 86 (2), 196-203. doi: 10.1016/j.antiviral.2010.02.318

Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth

Johnstone, Ken D., Karoli, Tomislav, Liu, Ligong, Dredge, Keith, Copeman, Elizabeth, Li, Cai Ping, Davis, Kat, Hammond, Edward, Bytheway, Ian, Kostewicz, Edmund, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A., Charman, William N., Harenberg, Job, Gonda, Thomas J. and Ferro, Vito (2010). Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth. Journal of Medicinal Chemistry, 53 (4), 1686-1699. doi: 10.1021/jm901449m

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

Hammond, Edward, Li, Cai Ping and Ferro, Vito (2010). Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening. Analytical Biochemistry, 396 (396), 112-116. doi: 10.1016/j.ab.2009.09.007

Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate

Fairweather, J.K., Karoli, T., Liu, L., Bytheway, I. and Ferro, V. (2009). Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate. Carbohydrate Research, 344 (17), 2394-2398. doi: 10.1016/j.carres.2009.09.012

A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins

Cochran, S., Ping Li, C. and Ferro, V. (2009). A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins. Glycoconjugate Journal, 26 (5), 577-587. doi: 10.1007/s10719-008-9210-0

An improved synthetic route to the potent angiogenesis inhibitor benzyl manα(1→3)-Manα(1→3)-Manα(1→3) -Manα(1→2)-Man Hexadecasulfate

Liu, LG, Johnstone, KD, Fairweather, JK, Dredge, K and Ferro, V (2009). An improved synthetic route to the potent angiogenesis inhibitor benzyl manα(1→3)-Manα(1→3)-Manα(1→3) -Manα(1→2)-Man Hexadecasulfate. Australian Journal of Chemistry, 62 (6), 546-552. doi: 10.1071/CH09015

Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88

Fairweather, J.K., Hammond, E., Johnstone, K.D. and Ferro, V. (2008). Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88. Bioorganic & Medicinal Chemistry, 16 (2), 699-709. doi: 10.1016/j.bmc.2007.10.044

Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides

Liu, Ligong, Bytheway, Ian, Karoli, Tomislav, Fairweather, Jon K., Cochran, Siska, Li, Caiping and Ferro, Vito (2008). Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides. Bioorganic & Medicinal Chemistry Letters, 18 (1), 344-349. doi: 10.1016/j.bmcl.2007.10.071

Herpes simplex virus type 2 glycoprotein G is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to cells

Adamiak, Beata, Ekblad, Maria, Bergström, Tomas, Ferro, Vito and Trybala, Edward (2007). Herpes simplex virus type 2 glycoprotein G is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to cells. Journal of Virology, 81 (24), 13424-13434. doi: 10.1128/JVI.01528-07

Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88

Ekblad, Maria, Adamiak, Beata, Bergefall, Kicki, Nenonen, Hannah, Roth, Anette, Bergstrom, Tomas, Ferro, Vito and Trybala, Edward (2007). Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88. Virology, 367 (2), 244-252. doi: 10.1016/j.virol.2007.05.040

PI-88 and novel heparan sulfate mimetics inhibit angiogenesis

Ferro, Vito, Dredge, Keith, Liu, Ligong, Hammond, Edward, Bytheway, Ian, Li, Caiping, Johnstone, Ken, Karoli, Tomislav, Davis, Kat, Copeman, Elizabeth and Gautam, Anand: (2007). PI-88 and novel heparan sulfate mimetics inhibit angiogenesis. Seminars in Thrombosis and Hemostasis, 33 (5), 557-562. doi: 10.1055/s-2007-982088

Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor

Zammit, S. C., Ferro, V., Hammond, E. and Rizzacasa, M. A. (2007). Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor. Organic and Biomolecular Chemistry, 5 (17), 2826-2834. doi: 10.1039/b708594j

Molecular basis for resistance of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.

Ekblad, M., Adamiak, B., Bergefall, K., Nenonen, H., Roth, A., Bergstrom, T, Ferro, V. and Trybala, E. (2007). Molecular basis for resistance of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.. Virology (367), 244-252.

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

Adams, Y., Freeman, C., Schwartz-Albiez, R., Ferro, V., Parish, C.R. and Andrews, K.T. (2006). Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. Antimicrobial Agents and Chemotherapy, 50 (8), 2850-2852. doi: 10.1128/AAC.00313-06

Spectroscopic and structural characterization of products arising from the base-promoted benzylation of 3-sulfolene

Bonnet, Muriel, Banwell, Martin G., Willis, Anthony C. and Ferro, Vito (2006). Spectroscopic and structural characterization of products arising from the base-promoted benzylation of 3-sulfolene. Arkivoc, 2006 (x), 35-41. doi: 10.3998/ark.5550190.0007.a05

Anti-herpes simplex virus activities of two novel disulphated cyclitols

Ekblad, M., Bergström, T., Banwell, M. G., Bonnet, M., Renner, J., Ferro, V. and Trybala, E. (2006). Anti-herpes simplex virus activities of two novel disulphated cyclitols. Antiviral Chemistry and Chemotherapy, 17 (2), 97-106. doi: 10.1177/095632020601700205

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid

Pearson, A.G., Kiefel, M.J.., Ferro, V. and von Itzstein, M. (2005). Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid. Carbohydrate Research, 340 (13), 2077-2085. doi: 10.1016/j.carres.2005.06.029

Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88)

Karoli, Tomislav, Liu, Ligong, Fairweather, Jon K., Hammond, Edward, Li, Cai Ping, Cochran, Siska, Bergefall, Kicki, Trybala, Edward, Addison, Russell S. and Ferro, Vito (2005). Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88). Journal of Medicinal Chemistry, 48 (26), 8229-8236. doi: 10.1021/jm050618p

The synthesis and biological evaluation of two analogues of the C-riboside showdomycin

Renner, J., Kruszelnicki, I., Adamiak, B., Willis, A.C., Hammond, E., Su, S., Burns, C., Trybala, E., Ferro, V. and Banwell, M.G. (2005). The synthesis and biological evaluation of two analogues of the C-riboside showdomycin. Australian Journal of Chemistry, 58 (2), 86-93. doi: 10.1071/CH04273

Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins

Freeman, Craig, Liu, Ligong, Banwell, Martin G., Brown, Kathryn J., Bezos, Anna, Ferro, Vito and Parish, Christopher R. (2005). Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins. Journal of Biological Chemistry, 280 (10), 8842-8849. doi: 10.1074/jbc.M410769200

The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448

Fairweather, Jon K., Karoli, Tomislav and Ferro, Vito (2004). The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448. Bioorganic & Medicinal Chemistry, 12 (23), 6063-6075. doi: 10.1016/j.bmc.2004.09.005

A synthetic heparanase inhibitor reduces proteinuria in passive heymann nephritis

Levidiotis, V., Freeman, C., Punler, M., Martinello, P., Creese, B., Ferro, V., van der Vlag, J., Berden, Jo H.M., Parish, C.R. and Power, D.A. (2004). A synthetic heparanase inhibitor reduces proteinuria in passive heymann nephritis. Journal of the American Society of Nephrology, 15 (11), 2882-2892. doi: 10.1097/01.ASN.0000142426.55612.6D

The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation

Ferro, V., Hammond, E. and Fairweather, J. K. (2004). The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation. Mini Reviews in Medicinal Chemistry, 4 (6), 693-702. doi: 10.2174/1389557043403729

The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus

Nyberg, K., Ekblad, M., Bergström, T., Freeman, C., Parish, C.R., Ferro, V. and Trybal, E. (2004). The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus. Antiviral Research, 63 (1), 15-24. doi: 10.1016/j.antiviral.2004.01.001

Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries

Liu, L., Li, C.P., Cochran, S. and Ferro, V. (2004). Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries. Bioorganic & Medicinal Chemistry Letters, 14 (9), 2221-2226. doi: 10.1016/j.bmcl.2004.02.017

The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448.

Fairweather, J.K., Karoli, T. and Ferro, V. (2004). The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448.. Bioorganic & Medicinal Chemistry (12), 6063-6075.

Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance

Cochran, S., Li, C., Fairweather, J.K., Kett, W.C., Coombe, D.R. and Ferro, V. (2003). Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance. Journal of Medicinal Chemistry, 46 (21), 4601-4608. doi: 10.1021/jm030180y

The development of the novel angiogenesis inhibitor PI-88 as an anticancer drug

Ferro, V. and Don, R. (2003). The development of the novel angiogenesis inhibitor PI-88 as an anticancer drug. Australasian Biotechnology, 13 (1), 38-39.

Preparation and anticoagulant activity of the phosphosulfomannan PI-88

Yu, GL, Gunay, NS, Linhardt, RJ, Toida, T, Fareed, J, Hoppensteadt, DA, Shadid, H, Ferro, V, Li, CP, Fewings, K, Palermo, MC and Podger, D (2002). Preparation and anticoagulant activity of the phosphosulfomannan PI-88. European Journal of Medicinal Chemistry, 37 (10), 783-791. doi: 10.1016/S0223-5234(02)01347-8

Synthesis of [C-14]- and [S-35]-labelled PI-88 for pharmacokinetic and tissue distribution studies

Ferro, V, Li, CP, Wang, B, Fewings, K, King, AR, Hammond, E and Creese, BR (2002). Synthesis of [C-14]- and [S-35]-labelled PI-88 for pharmacokinetic and tissue distribution studies. Journal of Labelled Compounds & Radiopharmaceuticals, 45 (9), 747-754. doi: 10.1002/jlcr.591

Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC

Ferro, V, Li, CP, Fewings, K, Palermo, MC, Linhardt, RJ and Toida, T (2002). Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC. Carbohydrate Research, 337 (2), 139-146. doi: 10.1016/S0008-6215(01)00300-7

Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.

Ferro, V., Li, C.P., Fewings, K., Palermo, M.C., Linhardt, R.J. and Toida, T. (2002). Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.. Carbohydrate Research (337), 139-146.

Preparation and anticoagulant activity of the phosphosulfomannan PI-88

Yu, G., Gunay, N.S., Linhardt, R.J., Toida, T., Fareed, J., Hoppensteadt, D.A., Shadid, H., Ferro, V., Li, C., Fewings, K., Palermo, M.C. and Podger, D. (2002). Preparation and anticoagulant activity of the phosphosulfomannan PI-88. European Journal of Medicinal Chemistry (37), 783-791.

Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies

Ferro, V., Li, C., Wang, B., Fewings, K., King, A.R., Hammond, E. and Creese, B.R. (2002). Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies. Journal of Labelled Compounds and Radio-pharmaceuticals (45), 747-754.

Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88

Ferro, V, Fewings, K, Palermo, MC and Li, CP (2001). Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88. Carbohydrate Research, 332 (2), 183-189. doi: 10.1016/S0008-6215(01)00061-1

Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides

Wall, D., Douglas, S., Ferro, V., Cowden, W. and Parish, C. (2001). Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides. Thrombosis Research, 103 (103), 325-335. doi: 10.1016/S0049-3848(01)00314-0

Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88

Ferro, V., Fewings, V., Palermo, M.C. and Li, C.P. (2001). Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88. Carbohydrate Research (332), 183-189.

Targeting glycosaminoglycan-protein interactions

Ferro, V. and Devine, P. (2001). Targeting glycosaminoglycan-protein interactions. Chemistry in Australia (68), 18-21.

Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases

Ferro, V, Weiler, L and Withers, SG (1998). Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. Carbohydrate Research, 306 (4), 531-538. doi: 10.1016/S0008-6215(98)00011-1

Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases

Ferro, V., Weiler, L. and Withers, S.G. (1998). Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. Carbohydrate Research (306), 531-538.

N-Glycosyl phosphonamidates: potential transition-state analogue inhibitors of glycopeptidases

Ferro, V., Weiler, L., Withers, S.G. and Ziltener, H. (1998). N-Glycosyl phosphonamidates: potential transition-state analogue inhibitors of glycopeptidases. Canadian Journal of Chemistry, 76 (76), 313-318. doi: 10.1139/cjc-76-3-313

Internally quenched fluorogenic, alpha-helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides

Mehta, S., Meldal, M., Ferro, V., Duus, J.O. and Bock, K. (1997). Internally quenched fluorogenic, alpha-helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides. Journal of the Chemical Society: Perkin Transactions I (1), 1365-1374. doi: 10.1039/a607624f

The synthesis of some epoxyalkyl Beta-C-Glycosides as potential inhibitors of Beta-Glucan hydrolases

Best, W.M., Ferro, V., Harle, J., Stick, R.V. and Tilbrook, D.M.G. (1997). The synthesis of some epoxyalkyl Beta-C-Glycosides as potential inhibitors of Beta-Glucan hydrolases. Australian Journal of Chemistry, 50 (5), 463-472. doi: 10.1071/C97015

Substrate specificity of endoglucanase A from Cellulomonas fimi: fundamental differences between endoglucanases and exoglucanases from family 6

Damude, H.G., Ferro, V,, Withers, S.G. and Warren, R.A. (1996). Substrate specificity of endoglucanase A from Cellulomonas fimi: fundamental differences between endoglucanases and exoglucanases from family 6. Biochemistry Journal, 315 (315), 467-472. doi: 10.1042/bj3150467

Analysis of the H-1-Nmr Spectra of Some Diethyl Phosphonates

Byrne, LT, Ferro, V, Stevenson, S and Stick, RV (1994). Analysis of the H-1-Nmr Spectra of Some Diethyl Phosphonates. Magnetic Resonance in Chemistry, 32 (12), 749-752. doi: 10.1002/mrc.1260321209

Synthesis of 2'-Acylated and 2''-O-Acylated Maltotriosides as Potential Fluorescence-Quenched Substrates for Alpha-Amylase

Ferro, V, Meldal, M and Bock, K (1994). Synthesis of 2'-Acylated and 2''-O-Acylated Maltotriosides as Potential Fluorescence-Quenched Substrates for Alpha-Amylase. Journal of the Chemical Society-Perkin Transactions 1 (15), 2169-2176. doi: 10.1039/p19940002169

Analysis of the 1H NMR spectra of some diethyl phosphonates

Byrne L.T., Ferro, V., Stevenson, S. and Stick, R.V. (1994). Analysis of the 1H NMR spectra of some diethyl phosphonates. Magnetic Resonance in Chemistry (32), 749-752.

Synthesis of 2'- and 2"-O-acylated maltotriosides as potential fluorescence-quenched substrates for alpha-amylase

Ferro, V., Meldal, M. and Bock, K. (1994). Synthesis of 2'- and 2"-O-acylated maltotriosides as potential fluorescence-quenched substrates for alpha-amylase. Journal of the Chemical Society Perkin Transactions I, 2169-2176.

Approaches to the synthesis of retronecine from some pyrrolidine precursors

Clare, B.W., Ferro, V., Skelton, B.W., Stick, R.V. and White, A.H. (1993). Approaches to the synthesis of retronecine from some pyrrolidine precursors. Australian Journal of Chemistry, 46 (46), 805-824. doi: 10.1071/CH9930805

The synthesis of some pyrrolidines as potential precursors to retronecine

Ferro, V., Skelton, B.W., Stick, R.V. and White, A.H. (1993). The synthesis of some pyrrolidines as potential precursors to retronecine. Australian Journal of Chemistry, 46 (46), 787-803. doi: 10.1071/CH9930787

An improvement in the preparation of some carbohydrate benzylidene acetals

Ferro, V., Mocerino, M., Stick, R.V. and Tilbrook, D.M.G. (1988). An improvement in the preparation of some carbohydrate benzylidene acetals. Australian Journal of Chemistry, 41 (5), 813-815. doi: 10.1071/CH9880813

Micrornas as novel anti-angiogenesis therapeutic targets

Plummer, Prue N., Balsara, Spenta, Umer, Brittany, Taft, Ryan, Ferro, Vito, Mattick, John S., Swarbrick, Alex, McMillan, Nigel, Mittal, Vivek and Mellick, Albert S. (2013). Micrornas as novel anti-angiogenesis therapeutic targets. 8th Meeting of the Australasian GeneTherapy-Society, Sydney, NSW Australia, 08-10 May 2013. Hoboken, NJ United States: John Wiley and Sons Inc.. doi: 10.1002/jgm.2740

Nanoparticle Delivery of Rna-Based Therapy to Modulate Tumour Vasculature: as a Next Generation Anticancer Therapy

Plummer, Prue N., Balsara, Spenta, Ferro, Vito, Mittal, Vivek and Mellick, Albert S. (2013). Nanoparticle Delivery of Rna-Based Therapy to Modulate Tumour Vasculature: as a Next Generation Anticancer Therapy. 8th Meeting of the Australasian-Gene-Therapy-Society, Sydney Australia, 08-10 May 2013. Hoboken, NJ United States: Jossey Bass, Ed. and Pub.. doi: 10.1002/jgm.2740

Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy

Dredge, K, Davis, K, Liu, L, Johnstone, K, Handley, P, Wimmer, N, Bytheway, I, Hammond, E, Li, CP, Rowley, J, Ferro, V and Gautam, A (2007). Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, San Francisco, CA, United States, 22-26 October 2007. Philadelphia, PA, United States: American Association for Cancer Research.

PI-88, a heparanase inhibitor showing promising evidence of patient benefit in phase II clinical trials.

Gautam, AM, Ferro, V, Wilson, EA, Freeman, C and Parish, C (2005). PI-88, a heparanase inhibitor showing promising evidence of patient benefit in phase II clinical trials.. AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia Pa, Nov 14-18, 2005. PHILADELPHIA: AMER ASSOC CANCER RESEARCH.

Pharmacokinetics of [35s] PI-88 in rats

Creese, B., Ferro, V., King, A. R., Mardon, K. M., Dickinson, R. G., Punler, M.J. and Dodds, H. (2001). Pharmacokinetics of [35s] PI-88 in rats. Annual Scientific Meeting of ASCEPT, Dunedin NZ, 3-5 December 2001. Melbourne: ASCEPT.

Novel sulfated oligosaccharide derivatives

Ferro, V., Karoli, T., Liu, L., Handley, P.N., Johnstone, K.D., Wimmer, N. and Hammond, E.T. (2009). Novel sulfated oligosaccharide derivatives. WO/2009/049370.

Small molecule glycosaminoglycan mimetics

Banwell, M. G., Bonnet, M., Ferro, V., Kreipl, A., Renner, J. and Offermann, D. A. (2006). Small molecule glycosaminoglycan mimetics. WO/2006/135973.

Sulfated oligosaccharide derivatives

Ferro, Vito, Fairweather, Jon, Karoli, Tomislav and Liu, Ligong (2005). Sulfated oligosaccharide derivatives. WO/2005/085264.

Glycosaminoglycan (GAG) mimetics

Don, Robert Hugh, Ferro, Vito, Bytheway, Ian, Cochran, Siska, Fairweather, Jon Krueger, Hammond, Edward Timothy, Karoli, Tomislav, Li, Cai Ping and Liu, Ligong (2005). Glycosaminoglycan (GAG) mimetics. WO/2005/061523.