Heparan sulfate mimetics: versatile tools for chemical biology (2017–2019)
This project aims to develop novel chemical tools to study heparan sulfate-binding proteins. Heparan sulfate is a complex polysaccharide that is ubiquitously expressed on mammalian cells and interacts with a wide variety of proteins to mediate numerous biological and pathological functions. The precise details of these interactions remain poorly understood. The homogeneous, structurally defined compounds expected to be developed in this project will be used to unravel the critical roles played by heparan sulfate and its binding partners in biology, leading to a better, molecular-level understanding of these fundamental processes. The outcomes may have many future applications in biotechnology and drug development.