Professor James De Voss

Deputy Head of School

School of Chemistry and Molecular Biosciences
Faculty of Science
j.devoss@uq.edu.au
+61 7 336 53825
0412 188 182

Overview

James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.

Qualifications

  • Doctor of Philosophy, University of Cambridge
  • Bachelor of Science (Honours), The University of Queensland

Publications

View all Publications

Publications

Book Chapter

  • De Voss, J. and Cryle, M. (2007). Carbon-Carbon Bond Cleavage by P450 Systems. In A. Sigel, H. Sigel and R. Sigel (Ed.), The Ubiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences, Volume 3 (pp. 397-435) United Kingdom: Wiley & Sons.

  • Ortiz de Montellano, P.R. and De Voss, J. J. (2005). Substrate oxidation by cytochrome P450 enzymes. In P. Ortiz de Montellano (Ed.), Cytochrome P450: Structure, Mechanism and Biochemistry 3rd ed. (pp. 183-245) New York: Kluwer/Plenum.

Journal Article

Conference Publication

  • Yong, Ken W.L., De Voss, James J., Hooper, John N.A. and Garson, Mary J. (2011). Spectroscopic insights into Cyclic Polyketide Peroxides: New Plakortolides from Plakinastrella clathrata Kirkpatrick, 1900. In: 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity. 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity, Brisbane, Australia, (159-160). 10 - 15 July 2011.

  • Yong, Ken W., Lambert, Lynette K., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of bioactive cyclic peroxide metabolites. In: NZ Institute of Chemistry Conference 2011: Book of Abstracts 2011. NZ Institute of Chemistry Conference (NZIC, 2011), Hamilton, N.Z., (91-91). 27 November-1 December 2011.

  • Yong, Ken W.L., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of natural products. In: PERCH-CIC Congress VII: Chemistry, Environment and Society. Abstracts of the International Congress for Innovation in Chemistry. International Congress for Innovation in Chemistry (VII, PERCH-CIC, 2011), Pattaya, Thailand, (9-9). 4-7 May 2011.

  • Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: Plakortolide F and 6-epiplakortolide F. In: 5th Annual Symposium on Marine Natural Products and Drug Discovery, Pohan, South Korea, (). September 2010.

  • Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: plakortolide F and 6-epiplakortolide F. In: 6th Annual SCMB Research Students Symposium, Brisbane, QLD, Austalia, (). 25 November 2010.

  • Singh, Arti, Cryle, M., Hunter, D,, Stok, J. and De Voss, J. (2009). Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations. In: Hirofumi Shoun and Hideo Ohkawa, Proceedings of the 16th International conference on Cytochrome P450. ICCC2009: 16th International Conference on Cytochrome P450. Biochemistry, Biophysics, Biotechnology, Nago, Okinawa, Japan, (69-72). 21-25 June 2009.

  • Penman, K., Bone, K.M., Hayes, P.C., De Voss, J., Agarwal, A., Murali, B, Mundkinajeddu, D., Mayachari, A., Shenoy, R. and Lehmann, R. P. (2007). NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide. In: A. Nahrstedt, 55th International Congress & Annual Meeting of the Society for Medicinal Plant Research, Karl Franzens University, Graz, Austria, (902-902). 2-6 September, 2007.

  • Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J J, Stuthe, J. M., Bone, K. M. and Lehmann, R P (2006). Bilberry adulteration using the food dye amaranth. In: RACI Natural Products Group Symposium. RACI Natural Products Group Symposium, Wollongong, (Abstract). 29 Sept, 2006.

  • Stuthe, J. M., Lambert, L. K., Lehmann, R P, Kitching, W and De Voss, J J (2006). Chemical constituents of Chamaelirium luteum. In: ANZMAG. ANZMAG, Murramarang, NSW, (). 13-16 Feb, 2006.

  • De Voss, J J (2006). Insect spiroacetal biosynthesis. In: Biodiversity- IUPAC International Conference. Biodiversity- IUPAC International Conference, Kyoto, (Abstract). 23-28 July, 2006.

  • Slessor, K., Schloendorn, J. and De Voss, J. J. (2005). Alternative reactions catalysed by cytochrome P450cin. In: Connect 2005 (RACI). Connect 2005, Sydney, (Abstract). 3-7 July, 2005.

  • Slessor, K. and De Voss, J. J. (2005). C-C bond cleavaged reactions catalysed by cytochrome P450. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 25 Nov, 2005.

  • De Voss, J. J. (2005). Cyclopropyl containing fatty acids as probes of cytochrome P450. In: Prof Michael Paddon-Rowe Symposium. Prof Michael Paddon-Rowe Symposium, Sydney, (Abstract). 25 Feb, 2005.

  • Farlow, A. J. and De Voss, J. J. (2005). Cytochrome P450cin - alternative reactions with alternative substrates. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 25 Nov, 2005.

  • De Voss, J. J., Cryle, M. J. and Hayes, P. Y. N. (2005). Modified fatty acids as cytochrome P450 substrates. In: 14th International Conference on Cytochromes P450. 14th International Conference on Cytochromes P450, Dallas, (109-114). 31 May - 5 June, 2005.

  • Booth, Y. K., Schwartz, B. D., Fletcher, M. T., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly). In: 14th European Symposium in Organic Chemistry. 14th European Symposium in Organic Chemistry, Helsinki, (Abstract). 4-8 July, 2005.

  • Matovic, N. J. and De Voss, J. J. (2005). Synthesis of polyunsaturated alkyl amide constituents from Echinacea. In: 14th European Symposium in Organic Chemistry. 14th European Symposium in Organic Chemistry, Helsinki, (Abstract). 4-8 July, 2005.

  • Stuthe, J. M. U., Lambert, L. K., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2004). Chemical constituents of Chamaelirum luteum by NMR. In: ANZMAG 2004. ANZMAG 2004, Barossa Valley, (Abstract). 15-19 Feb, 2004.

  • Booth, Y. K. and De Voss, J. J. (2004). Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly). In: Brisbane Biological & Organic Chemistry Symposium. BBOCS, Brisbane, (Abstract). 26 Nov, 2004.

  • Slessor, K. E., Cavaignac, S. M., Hawkes, D. B. and De Voss, J. J. (2004). Is Asn242 important in P450cin catalysis?. In: 7th International Symposium on Cytochrome P450 Biodiversity & Biotechnology. 7th International Symposium on Cytochrome P450 Biodiversity &y, Hyogo, Japan, (Abstract). 1-5 Aug, 2004.

  • Cryle, M. J., Stuthe, J. M. U., Lambert, L. K. and De Voss, J. J. (2004). NMR elucidation of the products from cationic rearrangement of cyclopropane rings. In: ANZMAG2004, Abstracts of the 5th Conference of the Australian and New Zealand Society for Magnetic Resonance. ANZMAG 2004, Tanunda, South Australia, (). 15-19 Feb, 2004.

  • He, X., Deng, D., Cryle, M. J., De Voss, J. J., Groves, J. and Ortiz de Montellano, P.R. (2004). Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. In: 3rd International Congress of Porphyrins and Pthalocyanines. 3rd Int Congress of Porphyrins and Pthalocyanines, New Orleans, (Abstract). 11-16 July, 2004.

  • De Voss, J. J., Cryle, M. J. and Ortiz de Montellano, P.R. (2004). Small molecule probes of cytochrome P450 mechanism. In: 20th RACI Organic Chemistry Meeting. 20th RACI Organic Chemistry Meeting, Cairns, (Abstract). 4-8 July, 2004.

  • Ortiz de Montellano, P. R., He, X., Cryle, M. J. and De Voss, J. J. (2004). The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. In: Drug Metabolism Reviews. Proceedings of: 7th International Society for Study of Xenobiotics Meeting. ISSX 2004: 7th International Society for Study of Xenobiotics Meeting, Vancouver, (6-6). 29 August - 2 September, 2004. doi:10.1081/DMR-200027024

  • Slessor, K., Cavaignac, S. M., Hawkes, D. and De Voss, J. J. (2003). Dioxygen bond activation in P450cin. In: The Brisbane Biological and Organic Chemistry Symposium. The Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 28 Nov, 2003.

  • Bernhardt, Paul V., Aguey-Zinsou, Kondo-Francois, De Voss, James J. and Slessor, Kate E. (2003). Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism. In: Journal of Inorganic Biochemistry: Abstracts of the 11th International Conference on Biological Inorganic Chemistry. 11th International Conference on Biological Inorganic Chemistry, Cairns, Qld, (35-35). 19-23 July, 2003. doi:10.1016/S0162-0134(03)80462-2

  • Rosic, Nedeljka, Lonhienne, Thierry G.A., DeVoss, James J. and Gillam, Elizabeth M.J. (2003). Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism. In: Drug Metabolism Reviews: Proceedings 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX). 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Dijon, France, (46-46). 27 April - 1 May, 2003. doi:10.1081/DMR-120020120

  • Stuthe, J. M. U., Fletcher, M. T., Lambert, L. K., Penman, K. G., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2002). Chemical constitutents of chamaelirium luteum. In: 50th Annual Congress of the Society for Medicinal Plant Research. 50th Ann Congress of the Society for Medicinal Plant Research, Barcelona, ((Poster)). 8-12 September, 2002.

  • Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Kitching, W. and De Voss, J. J. (2002). Elucidation of biosynthetic pathways to the spiroacetals in Australian fruit fly species (Bactrocera sp.). In: Brisbane Biological & Organic Chemistry Symposium, Brisbane, ((Abstract)). 29 November, 2002.

  • De Voss, J. J. (2002). Mechanism of a C-C bond cleaving enzyme: P450 BioI. In: Cornforth Foundation for Chemistry Symposium. Cornforth Foundation for Chemistry Symposium, Sydney, ((Abstract)). 30 September - 1 October, 2002.

  • De Voss, J. J. (2002). P450cin: A new P450 with a novel redox partner. In: 6th International Symposium on Cytochrome P450. 6th Int Symposium on Cytochrome P450, Los Angeles, ((Abstract)). 20-25 August, 2002.

  • Schwartz, B. D. and De Voss, J. J. (2002). Synthesis and characterisation of [2,4']-bisthaizolines, [2,4]-bisoxazolines, [4,2'] and [2,4']-thiazolinyloxazolines. In: IUPAC 14th International Conference on Organic Synthesis. IUPAC 14th International Conference on Organic Synthesis, Christchurch, ((Poster)). 14-18 July, 2002.

  • Cryle, M.J., Stok, J. and De Voss, J. J. (2001). Elucidation of the mechanism of carbon carbon bond cleavage. In: IUPAC World Chemistry Congress 2001. IUPAC World Chemistry Congress 2001, Brisbane, ((Poster)). July, 2001.

  • Lang, C. S. and De Voss, J. J. (2001). Enantioselective synthesis of labelled serine and cysteine. In: IUPAC World Chemistry Congress 2001. IUPAC World Chemistry Congress 2001, Brisbane, ((Poster)). July, 2001.

  • Pearson, A. G., Hawkes, D. B., De Voss, J. J. and Martin, J. L. (2001). Expression, purification and preliminary X-ray crystallographic trials of P450cin, an oxidative hemoprotein of Citrobacter braakii. In: Crystal 22, Society of Crystallographers in Australia and New Zealand. Crystal 22, Society of Crystallographers in Aust and NZ, Couran Cove, Qld, ((Poster)). 7-10 July, 2001.

  • Stok, J., Cryle, M. J. and De Voss, J. J. (2000). A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis. In: RACI Queensland Inorganic Group Symposium (BICS III). BICS III, Brisbane, (). 30 November, 2000.

  • Cryle, M. J., Stok, J. and De Voss, J. J. (2000). Elucidation of the mechanism of action of the cytochrome P450 enzyme BioI. In: Brisbane Biological and Organic Chemistry Symposium 2000. Brisbane Biological and Organic Chemistry Symposium 2000, Griffith University, (). 27 November, 2000.

  • Kim, D., Gillam, E. M. J., Aguinaldo, A. M., Notley, L., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., De Voss, J. J. and Guengerich, F. P. (2000). Formation of indigo by recombinant mammalian cytochrome P450. In: V.T. Marchesi, Faseb Journal: ASBMB/ASPET 2000 Proceedings. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, (A1435-A1435). 4 - 8 June, 2000.

  • Guengerich, F. P., Cai, H., Notley, L., De Voss, J. J. and Gillam, E. M. J. (2000). Oxidation of indole by human cytochrome P450 enzymes. In: V.T. Marchesi, Faseb Journal: ASBMB/ASPET 2000 Proceedings. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, (A1436-A1436). 4 - 8 June, 2000.

  • Stok, J., De Voss, J. J. and Kitching, W. (1999). Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis. In: Scientific Program and Abstracts of 1st Asia-Pacific Conference in Chemical Ecology. 1st Asia-Pacific Conference on Chemical Ecology, Shanghai, China, (53-54). 1 -4 November 1999.

  • De Voss, J. J. and Stok, J. E. (1997). Purification and characterisation of P450. In: Faseb Journal: Proceedings of 1997 Faseb Summer Research Conference On Amyloid. 1997 Faseb Summer Research Conference On Amyloid, Copper Mountain, Colorado, (A812-A812). 13-18 July, 1997.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Master Philosophy — Principal Advisor

    Other advisors:

Completed Supervision