The University of Queensland

Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues

Kremsmayr, Thomas and Muttenthaler, Markus (2022). Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues. Methods in Molecular Biology. (pp. 175-199) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1759-5_11

Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesis

Jadhav, Kirtikumar B, Woolcock, Katrina J and Muttenthaler, Markus (2020). Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesis. Peptide Synthesis. (pp. 41-57) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana. doi: 10.1007/978-1-0716-0227-0_4

Selenocystine peptides - synthesis, folding and applications

Muttenthaler, M. and Alewood, P. F. (2009). Selenocystine peptides - synthesis, folding and applications. Oxidative folding of peptides and proteins. (pp. 396-418) edited by Johannes Buchner. Cambridge , U.K.: Royal Society of Chemistry. doi: 10.1039/9781847559265-00396

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer

Liu, Huiping and Muttenthaler, Markus (2022). High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer. Biomedicines, 10 (7) 1595, 1-20. doi: 10.3390/biomedicines10071595

Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry

Hering, Anke, Jieu, Beverly, Jones, Alun and Muttenthaler, Markus (2022). Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry. Frontiers in Chemistry, 10 889154, 889154. doi: 10.3389/fchem.2022.889154

On the utility of chemical strategies to improve peptide gut stability

Kremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga and Muttenthaler, Markus (2022). On the utility of chemical strategies to improve peptide gut stability. Journal of Medicinal Chemistry, 65 (8), 6191-6206. doi: 10.1021/acs.jmedchem.2c00094

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides

Hering, Anke, Braga Emidio, Nayara and Muttenthaler, Markus (2022). Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. Chemical Communications, 58 (65), 9100-9103. doi: 10.1039/d2cc03752a

Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis

Baumgartner, Maximilian, Lang, Michaela, Holley, Hunter, Crepaz, Daniel, Hausmann, Bela, Pjevac, Petra, Moser, Doris, Haller, Felix, Hof, Fabian, Beer, Andrea, Orgler, Elisabeth, Frick, Adrian, Khare, Vineeta, Evstatiev, Rayko, Strohmaier, Susanne, Primas, Christian, Dolak, Werner, Köcher, Thomas, Klavins, Kristaps, Rath, Timo, Neurath, Markus F., Berry, David, Makristathis, Athanasios, Muttenthaler, Markus and Gasche, Christoph (2021). Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis. Gastroenterology, 161 (4), 1245-1256.e20. doi: 10.1053/j.gastro.2021.06.024

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767

Improving the gastrointestinal stability of linaclotide

Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina and Muttenthaler, Markus (2021). Improving the gastrointestinal stability of linaclotide. Journal of Medicinal Chemistry, 64 (12) acs.jmedchem.1c00380, 8384-8390. doi: 10.1021/acs.jmedchem.1c00380

Trends in peptide drug discovery

Muttenthaler, Markus, King, Glenn F., Adams, David J. and Alewood, Paul F. (2021). Trends in peptide drug discovery. Nature Reviews Drug Discovery, 20 (4), 309-325. doi: 10.1038/s41573-020-00135-8

Conformational selection of vasopressin upon V1a receptor binding

Che, Kateryna, Muttenthaler, Markus and Kurzbach, Dennis (2021). Conformational selection of vasopressin upon V1a receptor binding. Computational and Structural Biotechnology Journal, 19, 5826-5833. doi: 10.1016/j.csbj.2021.10.024

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Dekan, Zoltan, Kremsmayr, Thomas, Keov, Peter, Godin, Mathilde, Teakle, Ngari, Dürrauer, Leopold, Xiang, Huang, Gharib, Dalia, Bergmayr, Christian, Hellinger, Roland, Gay, Marina, Vilaseca, Marta, Kurzbach, Dennis, Albericio, Fernando, Alewood, Paul F., Gruber, Christian W. and Muttenthaler, Markus (2021). Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science, 12 (11), 4057-4062. doi: 10.1039/d0sc05501h

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

Peschel, Alicia, Cardoso, Fernanda C, Walker, Andrew A, Durek, Thomas, Stone, M Rhia L, Braga Emidio, Nayara, Dawson, Philip E, Muttenthaler, Markus and King, Glenn F (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21) acs.jmedchem.0c01107, 12773-12785. doi: 10.1021/acs.jmedchem.0c01107

Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms

Touchard, Axel, Mendel, Helen C., Boulogne, Isabelle, Herzig, Volker, Braga Emidio, Nayara, King, Glenn F., Triquigneaux, Mathilde, Jaquillard, Lucie, Beroud, Rémy, De Waard, Michel, Delalande, Olivier, Dejean, Alain, Muttenthaler, Markus and Duplais, Christophe (2020). Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms. ACS Pharmacology and Translational Science, 3 (6) acsptsci.0c00119, 1211-1224. doi: 10.1021/acsptsci.0c00119

The oxytocin receptor signalling system and breast cancer: a critical review

Liu, Huiping, Gruber, Christian W., Alewood, Paul F., Möller, Andreas and Muttenthaler, Markus (2020). The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene, 39 (37), 5917-5932. doi: 10.1038/s41388-020-01415-8

Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tract

Braga Emidio, Nayara, Brierley, Stuart M., Schroeder, Christina I. and Muttenthaler, Markus (2020). Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tract. ACS Pharmacology and Translational Science, 3 (4) acsptsci.0c00023, 583-597. doi: 10.1021/acsptsci.0c00023

Neuropeptide signalling systems -an underexplored target for venom drug discovery

Mendel, Helen C., Kaas, Quentin and Muttenthaler, Markus (2020). Neuropeptide signalling systems -an underexplored target for venom drug discovery. Biochemical Pharmacology, 181 114129, 114129. doi: 10.1016/j.bcp.2020.114129

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k

The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functions

Heuer, Jörn, Heuer, Franziska, Stürmer, René, Harder, Sönke, Schlüter, Hartmut, Braga Emidio, Nayara, Muttenthaler, Markus, Jechorek, Dörthe, Meyer, Frank and Hoffmann, Werner (2020). The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functions. International Journal of Molecular Sciences, 21 (7) 2508, 2508. doi: 10.3390/ijms21072508

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Duerrauer, Leopold, Muratspahić, Edin, Gattringer, Jasmin, Keov, Peter, Mendel, Helen C., Pfleger, Kevin D. G., Muttenthaler, Markus and Gruber, Christian W. (2019). I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor. Scientific Reports, 9 (1) 19295, 19295. doi: 10.1038/s41598-019-55675-w

Conotoxins: chemistry and biology

Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019). Conotoxins: chemistry and biology. Chemical Reviews, 119 (21), 11510-11549. doi: 10.1021/acs.chemrev.9b00207

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Braga Emidio, Nayara, Hoffmann, Werner, Brierley, Stuart M. and Muttenthaler, Markus (2019). Trefoil Factor Family: Unresolved Questions and Clinical Perspectives. Trends in Biochemical Sciences, 44 (5), 387-390. doi: 10.1016/j.tibs.2019.01.004

On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe

Muttenthaler, Markus, Nevin, Simon T., Inserra, Marco, Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2019). On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry, 73 (4), 327-333. doi: 10.1071/CH19456

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Liutkevičiūtė, Zita, Gil-Mansilla, Esther, Eder, Thomas, Casillas-Pérez, Barbara, Di Giglio, Maria Giulia, Muratspahić, Edin, Grebien, Florian, Rattei, Thomas, Muttenthaler, Markus, Cremer, Sylvia and Gruber, Christian W. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal, 32 (12), 6808-6821. doi: 10.1096/fj.201800443

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Herzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090

Contractility measurements of human uterine smooth muscle to aid drug development

Arrowsmith, Sarah, Keov, Peter, Muttenthaler, Markus and Gruber, Christian W. (2018). Contractility measurements of human uterine smooth muscle to aid drug development. Journal of Visualized Experiments, 2018 (131) e56639. doi: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery

Breger, Joyce C., Muttenthaler, Markus, Delehanty, James B., Thompson, Darren A., Oh, Eunkeu, Susumu, Kimihiro, Deschamps, Jeffrey R., Anderson, George P., Field, Lauren D., Walper, Scott A., Dawson, Philip E. and Medintz, Igor L. (2017). Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery. Nanoscale, 9 (29), 10447-10464. doi: 10.1039/c7nr03362a

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

Di Giglio, Maria Giulia , Muttenthaler, Markus, Harpsoe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F. , Gloriam, David E. and Gruber, Christian W. (2017). Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports, 7 (1) 41002, 41002. doi: 10.1038/srep41002

Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses

Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407

Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure

Busnelli, Marta, Kleinau, Gunnar, Muttenthaler, Markus, Stoev, Stoytcho, Manning, Maurice, Bibic, Lucka, Howell, Lesley A., McCormick, Peter J., Di Lascio, Simona, Braida, Daniela, Sala, Mariaelvina, Rovati, G. Enrico, Bellini, Tommaso and Chini, Bice (2016). Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure. Journal of Medicinal Chemistry, 59 (15), 7152-7166. doi: 10.1021/acs.jmedchem.6b00564

Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis

Muttenthaler, Markus, Albericio, Fernando and Dawson, Philip E. (2015). Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis. Nature Protocols, 10 (7), 1067-1083. doi: 10.1038/nprot.2015.061

Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles

Arranz-Gibert, Pol, Guixer, Bernat, Malakoutikhah, Morteza, Muttenthaler, Markus, Guzman, Fanny, Teixido, Meritxell and Giralt, Ernest (2015). Lipid bilayer crossing-the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles. Journal of the American Chemical Society, 137 (23), 7357-7364. doi: 10.1021/jacs.5b02050

Discovery, synthesis, and structure: activity relationships of conotoxins

Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11), 1-33. doi: 10.1021/cr400401e

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52), 21183-21188. doi: 10.1073/pnas.1311183110

Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Optical Nanosensing in Cells

Gemmill, Kelly Boeneman, Muttenthaler, Markus, Delehanty, James B., Stewart, Michael H., Susumu, Kimihiro, Dawson, Philip E. and Medintz, Igor L. (2013). Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Optical Nanosensing in Cells. Analytical and Bioanalytical Chemistry, 405 (19), 6145-6154. doi: 10.1007/s00216-013-6982-2

Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery

Gruber, Christian W., Koehbach, Johannes and Muttenthaler, Markus (2012). Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery. Future Medicinal Chemistry, 4 (14), 1791-1798. doi: 10.4155/FMC.12.108

Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea

Muttenthaler, Markus, Dutertre, Sebastien, Wingerd, Joshua S., Aini, John W., Walton, Hugh, Alewood, Paul F. and Lewis, Richard J. (2012). Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea. Nautilus, 126 (2), 47-56.

Discovery of defense- and neuropeptides in social ants by genome-mining

Gruber, Christian W. and Muttenthaler, Markus (2012). Discovery of defense- and neuropeptides in social ants by genome-mining. PloS One, 7 (3) e32559, e32559. doi: 10.1371/journal.pone.0032559

Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR

Mobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011). Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 (50), 11952-11955. doi: 10.1002/anie.201104169

Structure-activity studies on alpha-conotoxins

Muttenthaler, Markus, Akondi, Kalyana B. and Alewood, Paul F. (2011). Structure-activity studies on alpha-conotoxins. Current Pharmaceutical Design, 17 (38), 4226-4241. doi: 10.2174/138161211798999384

Modulating oxytocin activity and plasma stability by disulfide bond engineering

Muttenthaler, Markus, Andersson, Asa, Dantas de Araujo, Aline, Dekan, Zoltan, Lewis, Richard J. and Alewood, Paul F. (2010). Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry, 53 (24), 8585-8596. doi: 10.1021/jm100989w

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors

Gruber, Christian W., Muttenthaler, Markus and Freissmuth, Michael (2010). Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Current Pharmaceutical Design, 16 (28), 3071-3088. doi: 10.2174/138161210793292474

α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors

Grishin, Anton, Wang, Ching-I. A., Muttenthaler, Markus, Alewood, Paul F., Lewis, Richard J. and Adams, David J. (2010). α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 285 (29), 22254-22263. doi: 10.1074/jbc.M110.111880

Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists

Muttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010). Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 (10), 3514-3522. doi: 10.1021/ja910602h

p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group

Muttenthaler, Markus, Ramos, Yesica Garcia, Feytens, Debby, Dantas de Araujo, Aline and Alewood, Paul F. (2010). p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group. Biopolymers, 94 (4), 423-432. doi: 10.1002/bip.21502

Selenopeptide chemistry

Muttenthaler, Markus and Alewood, Paul F. (2008). Selenopeptide chemistry. Journal of Peptide Science, 14 (12), 1223-1239. doi: 10.1002/psc.1075

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide

Dutertre, Sébastien, Croker, Daniel, Daly, Norelle L., Andersson, Åsa, Muttenthaler, Markus, Lumsden, Natalie G., Craik, David J., Alewood, Paul F., Guillon, Gilles and Lewis, Richard J. (2008). Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide. Journal of Biological Chemistry, 283 (11), 7100-7108. doi: 10.1074/jbc.M706477200

Synthesis and characterisation of new ditetrazole-ligands as more rigid building blocks of envisaged iron(II) spin-crossover coordination polymers

Muttenthaler M., Bartel M., Weinberger P., Hilscher G. and Linert W. (2005). Synthesis and characterisation of new ditetrazole-ligands as more rigid building blocks of envisaged iron(II) spin-crossover coordination polymers. Journal of Molecular Structure, 741 (1-3), 159-169. doi: 10.1016/j.molstruc.2005.02.007

Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel

Conibear, Anne C. and Muttenthaler, Markus (2018). Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2018.03.001

Pharmacological Probes for Oxytocin/vasopressin Gpcr Subtypes Based On In-Vertebrate Peptide Homologs

Di Giglio, M. G., Muttenthaler, M. and Gruber, C. W. (2016). Pharmacological Probes for Oxytocin/vasopressin Gpcr Subtypes Based On In-Vertebrate Peptide Homologs. HOBOKEN: WILEY.

Expression and function of vasopressin receptor subtypes in human myometrium: implications for effective tocolysis

Arrowsmith, Sarah, Taylor, Olayisade, Muttenthaler, Markus and Wray, Susan (2016). Expression and function of vasopressin receptor subtypes in human myometrium: implications for effective tocolysis. HOBOKEN: WILEY-BLACKWELL.

Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease

Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.

New pharmacological tools to investigate oxytocin receptors in neurodevelopmental brain disorders

Busnelli, M., Leonzino, M., Silva, B., Dona, E., Manning, M., Muttenthaler, M. and Chini, B. (2015). New pharmacological tools to investigate oxytocin receptors in neurodevelopmental brain disorders. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, Aug 23-27, 2015. HOBOKEN: WILEY-BLACKWELL.

Re-Examining the Importance of Vasopressin Receptors in Myometrial Contraction.

Arrowsmith, Sarah, Wray, Susan and Muttenthaler, Markus (2015). Re-Examining the Importance of Vasopressin Receptors in Myometrial Contraction.. THOUSAND OAKS: SAGE PUBLICATIONS INC.

Insights into the molecular evolution of oxytocin receptor ligand binding

Koehbach, Johannes, Stockner, Thomas, Bergmayr, Christian, Muttenthaler, Markus and Gruber, Christian W. (2013). Insights into the molecular evolution of oxytocin receptor ligand binding. London, United Kingdom: Portland Press. doi: 10.1042/BST20120256

Peptide-mediated cellular delivery of semiconductor quantum dots

Gemmill, K.B., Muttenthaler, M., Delehanty, J., Deschamps, J., Susumu, K., Stewart, M., Dawson, P., Huston, A. and Medintz, I. (2013). Peptide-mediated cellular delivery of semiconductor quantum dots. Conference on Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, Baltimore, United States, Apr 29-May 01, 2013. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2015446

Novel sources for potent and selective GPCR modulators

Muttenthaler, M., Dawson, P. E., Gruber, C. W., Bergmayr, C., Freissmuth, M., Andersson, A., Vetter, I., Dutertre, S., Lewis, R. J. and Alewood, P. F. (2012). Novel sources for potent and selective GPCR modulators. unknown, unknown, unknown. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2447

Pharmacological applications of natural peptide libraries

Koehbach, Johannes, Muttenthaler, Markus, Gründemann, Carsten and Gruber, Christian W (2012). Pharmacological applications of natural peptide libraries. 18th Scientific Symposium of the Austrian Pharmacological Society (APHAR), Graz, Austria, 20-21 September, 2012. London, United Kingdom: Springer Nature. doi: 10.1186/2050-6511-13-s1-a31

Pharmacological characterization of circular plant peptides with oxytocin-like activity

Koehbach, J., O'Brien, M., Miazzo, M., Muttenthaler, M., Akcan, M., Smith, T. J., Craik, D. J., Freissmuth, M. and Gruber, C. W. (2012). Pharmacological characterization of circular plant peptides with oxytocin-like activity. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2449

Conotoxins - blueprints for GPCR drug discovery?

Muttenthaler, M., Gruber, C. W., Andersson, A., Vetter, I., Nevin, S. T., Grishin, A. A., Dutertre, S., Daly, N. L., Craik, D. J., Adams, D. J., Lewis, R. J. and Alewood, P. F. (2011). Conotoxins - blueprints for GPCR drug discovery?. 22nd American Peptide Symposium, San Diego, CA, United States, 25-30 June 2011. Hoboken, NJ, United States: John Wiley & Sons.

Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor

Muttenthaler, M. M., de Araujo, A. D., Andersson, A., Vetter, I., Gruber, C., Ramos, Y. Garcia, Feytens, D., Bergmayr, C., Freissmuth, M., Lewis, R. and Alewood, P. (2010). Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Selenocysteine in peptide drug design

Adams, D. J., Alewood, P. F., Choy, P. T., Craik, D. J., Daly, N. L., Grishin, A. A., Hu, S-H., Martin, J. L., Muttenthaler, M., Nevin, S. T., Ngo, S. T. and Noakes, P. G. (2008). Selenocysteine in peptide drug design. Royal Australian Chemical Institute (RACI) Annual Scientific Meeting: Drug Discovery and Development, Couran Cove Island Resort, Queensland, Australia, 13 - 17 July 2008.

Selenocysteine in peptide folding and drug design

Muttenthaler, M., Nevin, S. T., Grishin, A. A., Ngo, S. T., Choy, P. T., Daly, N. L., Hu, S-H., Martin, J. L., Noakes, P. G., Craik, D. J., Adams, D. J. and Alewood, P. F. (2008). Selenocysteine in peptide folding and drug design. XXth International Symposium on Medicinal Chemistry (EFMC-ISMC 2008), Vienna, Austria, 31 August - 4 September 2008.

Directed folding of alpha-conotoxins using selenocysteine

Muttenthaler, M. and Alewood, P. F. (2006). Directed folding of alpha-conotoxins using selenocysteine. 29th European Peptide Symposium, Gdansk, Poland, 3-8 September 2006. Chichester, U.K.: John Wiley & Sons. doi: 10.1002/psc.796

Peptide engineering - controlling the folding of disulfide-rich peptides

Muttenthaler, Markus (2009). Peptide engineering - controlling the folding of disulfide-rich peptides. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.