Dr Michael Landsberg

Senior Lecturer

School of Chemistry and Molecular Biosciences
Faculty of Science
m.landsberg@uq.edu.au
+61 7 336 53756

Overview

Research Interests

  • Characterisation of bacterial ABC toxins
  • Molecular mechanisms of Vps4-mediated viral infection
  • Structure and function of molecular machines
  • Method development for single particle cryo-EM

Research Impacts

The arrival of the 'genomic era' at the start of the 21st century brought with it unprecedented capabilities to identify the genes and proteins that are linked to human diseases. But in the current, post-genomic era, it has become increasingly clear that a list of genes involved in disease is not enough. Genes and the proteins they encode rarely act in isolation; rather they form networks of interactions with proteins and other molecules. It is critical to obtaining a full appreciation of how proteins come together and interact, and how this translates to specifc functional consequences..

Our group is interested in understanding the structure and function of biological assemblies. We have obtained undprecedented insights into the structural basis of protein-protein recognition in specific biological assemblies that have broadened our understanding of the ways in which proteins and other molecules come together and function as large, macromolecular machines in order to cooperatively achieve specific cellular functions. In particular, we were the first to discover how a new family of bacterial protein toxins are assembled into a multi-functional protein machinery that combines maturation, folding, transportation, targeting and injection of a potent cytotoxin into susceptible cells. These toxins were originally discovered in bateria that are naturally-occuring pathogens of insects and our discoveries have helped to guide strategies which might prove useful in the development of next generation biopesticides.

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Applied Science (Honours), C.Qld.

Publications

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

Journal Article

Conference Publication

Other Outputs

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors: