Unravelling the mechanism of vesicular docking in neurosecretory cells (2015–2018)
The fusion of secretory vesicles (SVs) by exocytosis underpins neuronal and hormonal communication. The
goal of this project is to unravel all the steps bringing these vesicles to the plasma membrane where they
dock. Specifically, we will unravel the role for the cytoskeleton in creating an interface where SV confinement
leads to the appropriate pairing of molecules mediating the fusion between the vesicles and the plasma
membrane. Unravelling these novel molecular mechanisms is essential for our understanding of neuronal
function in the healthy nervous and hormonal systems.