Professor Frederic Meunier

Professor

Queensland Brain Institute

Affiliate Professorial Res Fellow

Institute for Molecular Bioscience
f.meunier@uq.edu.au
+61 7 334 66373

Overview

Professor Frederic Meunier obtained his Masters degree in Neurophysiology at the Paris XI University, France in 1992 and completed his Ph.D in Neurobiology at the CNRS in Gif-sur-Yvette, France in 1996. He was the recipient of a European Biotechnology Fellowship and went on to postgraduate work at the Department of Biochemistry at Imperial College (1997-1999) and at Cancer Research UK (2000-2002) in London, UK. After a short sabbatical at the LMB-MRC in Cambridge (UK), he became a group leader at the School of Biomedical Sciences at the University of Queensland (Australia) in 2003. He joined the Queensland Brain Institute of the University of Queensland in 2007 and obtained an NHMRC senior research fellowship in 2009 renewed in 2014 with promotion. He became Professor in 2014 at the Queensland Brain Institute and is currently part of the Centre for Ageing Dementia Research.

Research Interests

  • Nanoscale organisation of the synapse
    Use of single molecule imaging to track botulinum neurotoxin interaction with the neuronal membrane Use of single molecule imaging to uncover the change in presynaptic nanoscale organization occurring during neurotransmitter release (endocytosis) Use of single molecule imaging to uncover the change in presynaptic nanoscale organization occurring during neurotransmitter release (exocytosis)
  • Track epigenetic modifications elicited by synaptic plasticity associated with memory
    Understanding how memory is encoded in neurons require a deeper understanding of how pre- and post-synaptic plasticity affect the mesoscale organisation of our DNA via epigenetic modifications.
  • PROJECT 3: Synaptic remodelling.
    Neurotrophins are signalling molecules capable of inducing neurite outgrowth but it is not clear how they can affect the overall physiology of the neuron when the soma is located as far away as 1 metre from the site of uptake. Our strategy will be to establish a versatile and accessible in vitro model based on compartmentalised cultures (Campenot chambers) closely matching the reality of the neuromuscular system. The principle is to monitor and analyse neurite outgrowth and establishment of functional synapses with myocytes in communicant chambers. The binding, uptake, packaging of neurotrophic factors, their retrograde transport and eventual delivery will be investigated with a series of technical approaches ranging from classical binding studies to imaging of synaptic activity, time-lapse fluorescent video microscopy imaging of fluorescently-tagged factors and immunocytochemical approaches.
  • Nanoscale initiation of neurodegenerative diseases
    Use of single molecule imaging to uncover the change in Fyn and associated signalling cascade occurring during the development of Alzheimer’s disease Use of single molecule imaging to uncover the change in a-synuclein nanoscale organization in neurons associated with various disease-causing mutations

Qualifications

  • Doctor of Philosophy, Universite de Paris XI - Sud
  • Master of Science, Universite de Paris XI - Sud
  • Bachelor of Science, Université de Nice Sophia-Antipolis

Publications

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Supervision

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Publications

Featured Publications

Book Chapter

  • Narayana, Vinod K., Kvaskoff, David and Meunier, Frederic A. (2017). New developments in free fatty acids and lysophospholipids: decoding the role of phospholipases in exocytosis. In Alice Pebay and Raymond C.B. Wong (Ed.), Lipidomics of stem cells (pp. 191-206) Cham, Switerland: Spinger Nature.

  • Harper, Callista B., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2015). Exploiting endocytic pathways to prevent bacterial toxin infection. In Daniel Ladant, Michel R. Popoff and Joseph E. Alouf (Ed.), The comprehensive sourcebook of bacterial protein toxins 4th ed. (pp. 1072-1094) Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-12-800188-2.00040-9

  • Wen, Peter J., Osborne, Shona L. and Meunier, Frederic A. (2012). Phosphoinositides in neuroexocytosis and neuronal diseases. In Marco Falasca and Peter K. Vogt (Ed.), Current topics in microbiology and immunology (pp. 87-98) Amsterdam, Netherlands: Springer. doi:10.1007/978-94-007-5025-8_4

  • Meunier, Frederic A., Mattei, Cesar F. and Molgo, Jordi (2009). Marine toxins potently affecting neurotransmitter release¹. In Fusetani, Nobuhiro and Kem, William (Ed.), Marine Toxins as Research Tools 1 ed. (pp. 159-186) Berlin & Heidelberg: Springer - Verlag. doi:10.1007/978-3-540-87895-7_6

  • Meunier, Frederic A. and Osborne, Shona L. (2008). Lipids and Secretory Vesicle Exocytosis. In Wang, Zhao-Wen (Ed.), Molecular Mechanisms of Neurotransmitter Release 1 ed. (pp. 239-261) United States: Springer. doi:10.1007/978-1-59745-481-0

Journal Article

Conference Publication

  • Harper, Callista B., Wang, Tong, Joensuu, Merja, Papadopulos, Andreas and Meunier, Frederic A. (2017). Nanoscale imaging of botulinum neurotoxin type a retrograde axonal trafficking. In: Rose Puleo, TOXINS: Basic Science and Clinical Aspects of Botulinum and other Neurotoxins, Madrid, Spain, (S37-S38). 18-21 January 2017. doi:10.1016/j.toxicon.2016.11.106

  • Wang, T., Martin, S., Papadopulos, A., Harper, C., Mavlyutov, T., Niranjan, D., Glass, N., Cooper-White, J., Sibarita, J. -B., Choquet, D., Davletov, B. and Meunier, F. (2015). Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type-A. In: 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (165-165). 23-27 August 2015.

  • Low, Pei Ching (Regine), Manzanero, Silvia, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frederic A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. In: 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, (56-56). Oct 26-29, 2014. doi:10.1016/j.cyto.2014.07.126

  • Martin, Sally, Harper, Callista B. and Meunier, Frederic A. (2012). Retrograde trafficking at the presynaptic nerve terminal using bacterial toxins. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (160-160). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.130

  • Chasserot-Golaz, S., Coorssen, J. R., Meunier, F. A. and Vitale, N. (2010). Lipid dynamics in exocytosis. In: Proceedings of the 15th International Symposium on Chromaffin Cell Biology: The Chromaffin Cell as a Stress Transducer. 15th International Symposium on Chromaffin Cell Biology, Merida, Mexico, (1335-1342). 12-16 November 2009. doi:10.1007/s10571-010-9577-x

  • Alvarez-Elizondo, Martha B., Roelofs, Susan H., Meunier, Frederic A., Heckenberg, Norman and Rubinsztein-Dunlop, Halina (2008). Noninvasive measurement of intracellular viscoelastic properties. In: Kishan Dholakia and Gabriel C. Spalding, Proceedings of SPIE: Optical Trapping and Optical Micromanipulation V. Optical Trapping and Optical Micromanipulation V, San Diego, United States, (70380D-1-70380D-12). 10-14 August 2008. doi:10.1117/12.793591

  • Meunier, FA, Ragnarsson, L, Proctor, D, Feng, ZP, Molgo, J, Zamponi, GW and Schiavo, G (2005). Glycerotoxin and the regulation of neurotransmitter release. In: Journal of Neurochemistry. 20th Biennial Meeting of the International-Society-for-Neurochemistry/European-Society-for-Neurochemistry, Innsbruck Austria, (132-132). Aug 21-26, 2005.

  • Schiavo, G, Meunier, FA, Feng, ZP, Molgo, J and Zamponi, GW (2004). Glycerotoxin stimulates neurosecretion by up-regulating N-type Ca2+ channel activity. In: 6th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry, Hong Kong Peoples R China, (36-36). Feb 04-07, 2004.

  • Meunier, F. A., Cooke, F. T., Osborne, S. L., Hammond, G., Domin, J., Parker, P. J. and Schiavo, G. (2004). Class II PI3-kinase C2 alpha is essential for ATP-dependent printing of neurosecretory granule exocytosis. In: Journal of General Physiology: Abstracts of the 58th Conference of the Society-of-Nutrition-Physiology. 58th Conference of the Society-of-Nutrition-Physiology, Gottingen, Germany, (19A-19A). 9-11 March, 2004.

  • Schiavo, G, Meunier, FA, Feng, ZP, Zamponi, GW and Molgo, J (2003). Glycerotoxin stimulates neurosecretion by up-regulating N-type calcium channel activity. In: Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, Wanchai Peoples R China, (28-28). Aug 03-08, 2003.

  • Lisk, G, Meunier, FA, Poran, PO, Mohammed, N, de Puva, A and Dolly, JO (2001). Synapse remodelling after neuroparalysis due to cleavage of SNAREs by botlulinum toxins. In: Toxicology. , , (21-21). .

  • Meunier, FA, Mattei, C, Colasante, C, Chameau, P, Ouanounou, G, Thieffry, M, Ushkaryov, YA, Dolly, JO, Kreger, AS and Molgo, J (2001). Trachynilysin, a stonefish protein that affects neurotransmitter release. In: Journal of Neurochemistry. , , (7-7). .

  • de Paiva, A, Meunier, FA, Molgo, J, Aoki, KR and Dolly, JO (1999). Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals. In: , , (3200-3205). . doi:10.1073/pnas.96.6.3200

  • Davletov, BA, Ashton, AC, Meunier, FA, Matsushita, H, Hirst, WD, Dolly, JO and Ushkarvov, YA (1998). alpha-Latrotoxin stimulates vesicle exocytosis via latrophilin- and PLC-mediated coupling of external and stored Ca-2 and induces Ca2+-independent membrane pores. In: European Journal of Neuroscience. , , (217-217). .

  • Molgo, J, Meunier, FA and Sellin, LC (1997). Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions. In: Teelken, A and Korf, J, 11th Meeting of the European-Society-for-Neurochemistry, Groningen Netherlands, (713-717). Jun 15-20, 1996.

  • Molgo, J, Meunier, FA and Sellin, LC (1996). Quantal transmitter release at botulinum-treated vertebrate neuromuscular junctions.. In: Journal of Neurochemistry. , , (S29-S29). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision