The neuronal PlKfyve complex regulates neurotransmission and neurodegeneration (2010–2013)
Neuronal communication is essential for the functioning of our bodies and mind. We have identified a novel pathway for the regulation of this process involving a little studied lipid, Pl3, 5P2. This lipid also appears to be important for neuronal survival. We will investigate the regulation and function of this lipid in neurons. The outcomes of this proposal will be an important step closer to understanding the processes underlying neuronal communication and neurodegeneration.