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Professor Juergen Goetz

Director of CJCADR

Clem Jones Centre for Ageing Dementia Research
Queensland Brain Institute
j.goetz@uq.edu.au
+61 7 334 66329

Overview

Professor Jürgen Götz is the Foundation Chair of Dementia Research and Director of the Centre for Ageing Dementia Research (CADR) at the Queensland Brain Institute (QBI), The University of Queensland. Götz studied biochemistry at the University of Basel, and earned his PhD in immunology in the laboratory of Nobel Laureate Georges Köhler at the Max-Planck-Institute in Freiburg, Germany (1989). After postdoctoral work at UCSF and the Preclinical Research Division at Novartis Ltd in Basel, he established his reputation in the Alzheimer’s field as a research group leader at the University of Zürich (1994–2005). From 2005 - 2012, before accepting his new position at the University of Queensland, he has been Chair of Molecular Biology and Director of the Alzheimer’s and Parkinson’s Laboratory at the Brain and Mind Research Institute of the University of Sydney. Götz uses transgenic animal models to contribute to a better understanding of the role of tau and amyloid-beta in Alzheimer’s disease and related dementias.

Qualifications

  • Doctor of Natural Science, Albert Ludwig University of Freiburg

Publications

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Grants

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Supervision

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Publications

Book Chapter

Journal Article

Conference Publication

  • SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56

    Lesne, Sylvain, Amar, Fatou, Sherman, Mathew, Rush, Travis, Larson, Megan, Chang, Liu, Gotz, Jurgen, Schneider, Julie, Bennett, David, Ashe, Karen and Buisson, Alain (2016). SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56. In: 14th International Athens/Springfield Symposium on Advances In Alzheimer Therapy, Athens, Greece, (S27-S27). Mar 09-12, 2016.

  • Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy

    Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

  • Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease

    Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

  • The many facets of dementia - basic science and translational strategies

    Gotz, Jurgen (2016). The many facets of dementia - basic science and translational strategies. In: Unknown, Unknown, (11-11). Unknown.

  • Deficient corticostriatal activity in ageing shortens patterns of goal-directed action

    Bertran-Gonzalez, J., Goetz, J., Balleine, B. W. and Matamales, M. (2015). Deficient corticostriatal activity in ageing shortens patterns of goal-directed action. In: Journal of Neurochemistry. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (369-369). Aug 23-27, 2015.

  • Propagation of tau phosphorylation following localised PP2A inhibition in wild-type mice

    Baker, S. L. and Goetz, J. (2015). Propagation of tau phosphorylation following localised PP2A inhibition in wild-type mice. In: Journal of Neurochemistry. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (270-270). Aug 23-27, 2015.

  • Reduced CA1 action potential firing in the rTg4510 mouse model of tauopathy due to abnormal activity at the axon initial segment

    Hatch, R. and Goetz, J. (2015). Reduced CA1 action potential firing in the rTg4510 mouse model of tauopathy due to abnormal activity at the axon initial segment. In: Journal of Neurochemistry. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (273-273). Aug 23-27, 2015.

  • Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's

    Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: Journal of Neurochemistry. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (277-278). Aug 23-27, 2015.

  • Neurotrophin regulation of Alzheimer's disease pathology

    Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (208-208). 23-27 August 2015. doi:10.1111/jnc.13188

  • Novel strategies to target tau and Ab toxicity

    Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186

  • Striatal deficits underlie conflicted patterns of action selection in ageing

    Matamales, M., Skrbis, Z., Balleine, B., Goetz, J. and Bertran-Gonzalez, J. (2015). Striatal deficits underlie conflicted patterns of action selection in ageing. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (144-144). 23-27 August 2015. doi:10.1111/jnc.13188

  • Novel treatment strategies for Alzheimer's disease

    Goetz, J., Ittner, L. M. and Matamales, M. (2011). Novel treatment strategies for Alzheimer's disease. In: European Neuropsychopharmacology. 24th Congress Meeting of European-College-of-Neuropsychopharmacology, Paris France, (S187-S188). Sep 03-07, 2011.

  • Novel functions of the protein tau in disease

    Gotz, Jurgen (2011). Novel functions of the protein tau in disease. In: Neuroscience Research. , , (E26-E26). . doi:10.1016/j.neures.2011.07.111

  • Axonal transport in tau transgenic mouse models

    Goetz, J. and Ittner, L. M. (2009). Axonal transport in tau transgenic mouse models. In: Journal of Neurochemistry. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig Germany, (59-59). Jul 11-14, 2009.

  • Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse

    Schroeder, H., Goetz, J., Pilz, K., Kuhlage, S., de Vos, R. A. I., Bauer, T., Selzer, A. and Koehler, C. (2009). Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse. In: New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009. 9th International Conference on Alzheimers and Parkinson's Diseases (AD/PD), Prague Czech Republic, (233-237). Mar 11-15, 2009.

  • Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice

    Rhein, Virginie, Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Droese, Stefan, Brandt, Ulrich, Mueller-Spahn, Franz, Czech, Christian, Goetz, Jurgen and Eckert, Anne (2008). Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice. In: Biochimica Et Biophysica Acta-Bioenergetics. 15th European Bioenergetic Conference, Dublin Ireland, (S85-S86). Jul 19-24, 2008. doi:10.1016/j.bbabio.2008.05.335

  • Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles

    Rhein, V, Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Savaskan, E., Mueller-Spahn, F., Czech, C., Goetz, J. and Eckert, A. (2007). Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles. In: Pharmacopsychiatry. 25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie, Munich Germany, (234-234). Oct 03-06, 2007.

  • A decade of tau transgenic animal models and beyond

    Gotz J., Deters N., Doldissen A., Bokhari L., Ke Y., Wiesner A., Schonrock N. and Ittner L.M. (2007). A decade of tau transgenic animal models and beyond. In: , , (91-103). . doi:10.1111/j.1750-3639.2007.00051.x

  • Transgenic animal models of Alzheimer's disease

    Gotz, J. (2006). Transgenic animal models of Alzheimer's disease. In: European Neuropsychopharmacology. 19th Congress of the European-College-of-Neuropsychopharmacology, Paris France, (S197-S197). Sep 16-20, 2006. doi:10.1016/S0924-977X(06)70110-9

  • Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro

    Pennanen, L, David, D, Hoerndli, F, Kurosinski, P, Chen, F, Schild, A, Ferrari, A, Nitsch, RM and Gotz, J (2004). Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro. In: Neurobiology of Aging. 9th International Conference on Alzheimers Disease and Related Disorders, Philadelphia Pa, (S255-S255). Jul 17-22, 2004. doi:10.1016/S0197-4580(04)80857-1

  • In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation

    Chen, E, Schild, A, Kurosinski, P, Pennanen, L, Hoerndli, E, David, D, Ferrari, A, Nitsch, RM and Gotz, J (2003). In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. In: European Neuropsychopharmacology. 16th Congress of the European-College-of-Neuropsychopharmacology, Prague Czech Republic, (S99-S100). Sep 20-24, 2003.

  • Amyloid-induced neurofibrillary tangle formation

    Gotz, J, Chen, F, Ferrari, A, Kurosinski, P, Schild, A, Nitsch, RM and van Dorpe, J (2002). Amyloid-induced neurofibrillary tangle formation. In: Neurobiology of Aging. , , (S567-S567). .

  • Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice

    Gotz, J, Chen, F and Nitsch, RM (2002). Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice. In: Mapping the Progress of Alzheimer'S and Parkinson'S Disease. 5th International Conference on the Progress in Alzheimers and Parkinsons Disease/9th International Catecholamine Symposium, Kyoto Japan, (139-144). Mar 31-Apr 05, 2001.

  • The role of beta-amyloid addressed in tau filament-forming mice

    Chen, F, Ferrari, A, Nitsch, RM and Gotz, J (2001). The role of beta-amyloid addressed in tau filament-forming mice. In: Journal of Neurochemistry. , , (8-8). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Dendritic role of tau and the Src kinase Fyn

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • The role of de novo protein synthesis in neurodegenerative disease

    Doctor Philosophy — Principal Advisor

  • Understanding ultrasound mediated blood brain barrier opening as a potential non invasive therapeutic approach in Alzheimer disease

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Synaptic Apoptosis in Alzheimer's Disease

    Doctor Philosophy — Principal Advisor

  • Investigating the role of tau in mitochondrial dynamics and quality control

    Doctor Philosophy — Principal Advisor

  • The Role of Microglia in Traumatic Brain Injury

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • New pet imaging agents for the early detection of alzheimers disease

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Investigating the therapeutic potential of tau-specific scFv intrabodies for the treatment of tauopathies

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Dynamic Reorganization of Presynaptic Proteins During Neurotransmission and Neuronal Degeneration.

    Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

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ResearcherID: C-2448-2014

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