Professor Jürgen Götz is the Foundation Chair of Dementia Research and Director of the Centre for Ageing Dementia Research (CADR) at the Queensland Brain Institute (QBI), The University of Queensland. Götz studied biochemistry at the University of Basel, and earned his PhD in immunology in the laboratory of Nobel Laureate Georges Köhler at the Max-Planck-Institute in Freiburg, Germany (1989). After postdoctoral work at UCSF and the Preclinical Research Division at Novartis Ltd in Basel, he established his reputation in the Alzheimer’s field as a research group leader at the University of Zürich (1994–2005). From 2005 - 2012, before accepting his new position at the University of Queensland, he has been Chair of Molecular Biology and Director of the Alzheimer’s and Parkinson’s Laboratory at the Brain and Mind Research Institute of the University of Sydney. Götz uses transgenic animal models to contribute to a better understanding of the role of tau and amyloid-beta in Alzheimer’s disease and related dementias.
Journal Article: Molecular Pathogenesis of the Tauopathies
Götz, Jürgen, Halliday, Glenda and Nisbet, Rebecca M. (2019) Molecular Pathogenesis of the Tauopathies. Annual Review of Pathology: Mechanisms of Disease, 14 239-261. doi:10.1146/annurev-pathmechdis-012418-012936
Journal Article: Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury
Mohamed, Abdalla Z., Cumming, Paul, Götz, Jürgen and Nasrallah, Fatima (2019) Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury. European Journal of Nuclear Medicine and Molecular Imaging, . doi:10.1007/s00259-018-4241-7
Journal Article: Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
Cummins, Nadia, Tweedie, Andrea, Zuryn, Steven, Bertran‐Gonzalez, Jesus and Götz, Jürgen (2018) Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO Journal, e99360. doi:10.15252/embj.201899360
Regulation of mRNA translation by the microtubule-associated protein Tau
(2019–2021) ARC Discovery Projects
Unravelling how exosomes induce and propagate tau pathology
(2019–2021) NHMRC Project Grant
MM Electrical Merchandising Mid-Career Fellowship (Alzheimer's Disease)
(2018–2024) Metal Manufacturers Limited
The Role of Tau in Mitochondrial Dynamics and Quality Control
(2018) Doctor Philosophy
Analysis of how tau spreads and forms aggregated lesions in Alzheimer¿s disease models
Doctor Philosophy
The role of tyrosine kinases Pyk2, Fyn and the tyrosine phosphatase STEP in neurodegeneration and neurophysiology
Doctor Philosophy
Stem cell therapy in Alzheimer's disease models: neurogenesis versus trophic support
Goetz, Juergen and Buettner, Sven (2012). Stem cell therapy in Alzheimer's disease models: neurogenesis versus trophic support. In Kuldip S. Sidhu (Ed.), Frontiers in pluripotent stem cells research and therapeutic potentials bench-to-bedside (pp. 220-226) London, United Kingdom: Bentham Science. doi:10.2174/97816080528991120101
Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models
Götz, Jürgen, David, Della C. and Ittner, Lars M. (2007). Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research (pp. 198-215) : Springer London. doi:10.1007/978-1-84628-440-3_12
Molecular Pathogenesis of the Tauopathies
Götz, Jürgen, Halliday, Glenda and Nisbet, Rebecca M. (2019) Molecular Pathogenesis of the Tauopathies. Annual Review of Pathology: Mechanisms of Disease, 14 239-261. doi:10.1146/annurev-pathmechdis-012418-012936
Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury
Mohamed, Abdalla Z., Cumming, Paul, Götz, Jürgen and Nasrallah, Fatima (2019) Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury. European Journal of Nuclear Medicine and Molecular Imaging, . doi:10.1007/s00259-018-4241-7
Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
Cummins, Nadia, Tweedie, Andrea, Zuryn, Steven, Bertran‐Gonzalez, Jesus and Götz, Jürgen (2018) Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO Journal, e99360. doi:10.15252/embj.201899360
Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondria
Polanco, Juan Carlos and Götz, Jürgen (2018) Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondria. The EMBO Journal, 37 22: . doi:10.15252/embj.2018100839
Rodent models for Alzheimer disease
Götz, Jürgen, Bodea, Liviu-Gabriel and Goedert, Michel (2018) Rodent models for Alzheimer disease. Nature Reviews Neuroscience, 19 10: 583-598. doi:10.1038/s41583-018-0054-8
Grimm, Amandine, Cummins, Nadia and Götz, Jürgen (2018) Local oxidative damage in the soma and dendrites quarantines neuronal mitochondria at the site of insult. iScience, 6 114-127. doi:10.1016/j.isci.2018.07.015
Pyk2 is a novel tau tyrosine kinase that is regulated by the tyrosine kinase fyn
Li, Chuanzhou and Götz, Jürgen (2018) Pyk2 is a novel tau tyrosine kinase that is regulated by the tyrosine kinase fyn. Journal of Alzheimer's Disease, 64 1: 205-221. doi:10.3233/JAD-180054
Modeling ultrasound propagation through material of increasing geometrical complexity
Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018) Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90 52-62. doi:10.1016/j.ultras.2018.05.014
Nisbet, Rebecca M. and Götz, Jürgen (2018) Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies. Journal of Alzheimer's Disease, 64 s1: S517-S527. doi:10.3233/JAD-179907
Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons
Polanco, Juan Carlos, Li, Chuanzhou, Durisic, Nela, Sullivan, Robert and Götz, Jürgen (2018) Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons. Acta Neuropathologica Communications, 6 1: 1-14. doi:10.1186/s40478-018-0514-4
Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice
Leinenga, Gerhard and Gotz, Jurgen (2018) Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 FEB: 1-10. doi:10.3389/fnins.2018.00055
A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles
Brici, David, Götz, Jürgen and Nisbet, Rebecca M. (2018) A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. Journal of Alzheimer's Disease : JAD, 61 3: 899-905. doi:10.3233/JAD-170610
Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018) Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 9: 2583-2602. doi:10.7150/thno.22852
Blackmore, Daniel G., Turpin, Fabrice, Mohamed, Abdalla Z., Zong, Fangrong, Pandit, Rucha, Pelekanos, Matthew, Nasrallah, Fatima, Sah, Pankaj, Bartlett, Perry F. and Gotz, Juergen (2018) Multimodal analysis of aged wild-type mice exposed to repeated scanning ultrasound treatments demonstrates long-term safety. Theranostics, 8 22: 6233-6247. doi:10.7150/thno.27941
Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies
Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017) Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 1: 22-40. doi:10.1038/nrneurol.2017.162
Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies
Forrest, Shelley L., Kril, Jillian J., Stevens, Claire H., Kwok, John B., Hallupp, Marianne, Kim, Woojin S., Huang, Yue, McGinley, Ciara V., Werka, Hellen, Kiernan, Matthew C., Götz, Jürgen, Spillantini, Maria Grazia, Hodges, John R., Ittner, Lars M. and Halliday, Glenda M. (2017) Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies. Brain : A Journal of Neurology, 141 2: 521-534. doi:10.1093/brain/awx328
Anders, S., Götz, J., Grifka, J. and Baier, C. (2017) Knorpelreparative Eingriffe am oberen Sprunggelenk: Therapieoptionen, Ergebnisse und technische Aspekte. Orthopade, 46 11: 938-946. doi:10.1007/s00132-017-3470-y
Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?
Cummins, Nadia and Götz, Jürgen (2017) Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?. Cellular and Molecular Life Sciences, 75 7: 1-12. doi:10.1007/s00018-017-2692-9
A corticostriatal deficit promotes temporal distortion of automatic action in ageing
Matamales, Miriam, Skrbis, Zala, Bailey, Matthew R, Balsam, Peter D, Balleine, Bernard W, Götz, Jürgen and Bertran-Gonzalez, Jesus (2017) A corticostriatal deficit promotes temporal distortion of automatic action in ageing. eLife, 6 . doi:10.7554/eLife.29908
Tau-based therapies in neurodegeneration: opportunities and challenges
Li, Chuanzhou and Götz, Jürgen (2017) Tau-based therapies in neurodegeneration: opportunities and challenges. Nature Reviews Drug Discovery, 16 12: 863-883. doi:10.1038/nrd.2017.155
Akute Lungenembolie: immer noch eine diagnostische und therapeutische Herausforderung?
Felgendreher, R., Härtel, D., Brockmeier, J., Bramlage, K., Aschenbrenner, T., Götz, J., Bramlage, P. and Tebbe, U. (2017) Akute Lungenembolie: immer noch eine diagnostische und therapeutische Herausforderung?. Medizinische Klinik - Intensivmedizin und Notfallmedizin, 112 6: 499-509. doi:10.1007/s00063-016-0221-5
Li, Chuanzhou and Götz, Jürgen (2017) Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.. EMBO Journal, 36 17: 3120-3138. doi:10.15252/embj.201797724
Ultrasound as a treatment modality for neurological diseases
Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017) Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 11: 470-471. doi:10.5694/mja16.01013
Amar, Fatou, Sherman, Mathew A., Rush, Travis, Larson, Megan, Boyle, Gabriel, Chang, Liu, Gotz, Jurgen, Buisson, Alain and Lesne, Sylvain E. (2017) The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Science Signaling, 10 478: eaal2021. doi:10.1126/scisignal.aal2021
Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017) Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 5: 1220-1230. doi:10.1093/brain/awx052
Hatch, Robert John, Wei, Yan, Xia, Di and Gotz, Jürgen (2017) Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta Neuropathologica, 133 5: 717-730. doi:10.1007/s00401-017-1674-1
Hilfsmittel in der Rheumatologie: Einschränkungen vorbeugen, Restfunktionen unterstützen
Fikentscher, T., Springorum, H. R., Grifka, J. and Götz, J. (2017) Hilfsmittel in der Rheumatologie: Einschränkungen vorbeugen, Restfunktionen unterstützen. Zeitschrift fur Rheumatologie, 76 3: 245-258. doi:10.1007/s00393-017-0288-2
Klinische Untersuchung des Handgelenkes und der Hand
Springorum, H. R., Baier, C., Götz, J., Schwarz, T., Benditz, A., Grifka, J. and Heers, G. (2017) Klinische Untersuchung des Handgelenkes und der Hand. Schmerz, 31 2: 179-193. doi:10.1007/s00482-017-0196-z
Hallux valgus: Ätiologie, diagnostische und therapeutische Prinzipien
Zirngibl, B., Grifka, J., Baier, C. and Götz, J. (2017) Hallux valgus: Ätiologie, diagnostische und therapeutische Prinzipien. Orthopade, 46 3: 283-296. doi:10.1007/s00132-017-3397-3
Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology
Ahmed, Rebekah M., Irish, Muireann, van Eersel, Janet, Ittner, Arne, Ke, Yazi D., Volkerling, Alexander, van der Hoven, Julia, Tanaka, Kimi, Karl, Tim, Kassiou, Michael, Kril, Jillian J., Piguet, Olivier, Goetz, Juergen, Kiernan, Matthew C., Halliday, Glenda M., Hodges, John R. and Ittner, Lars M. (2017) Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology. Neuroscience and Biobehavioral Reviews, 74 A: 126-138. doi:10.1016/j.neubiorev.2017.01.004
Psychological factors as risk factors for poor hip function after total hip arthroplasty
Benditz, Achim, Jansen, Petra, Schaible, Jan, Roll, Christina, Grifka, Joachim and Götz, Jürgen (2017) Psychological factors as risk factors for poor hip function after total hip arthroplasty. Therapeutics and Clinical Risk Management, 13 237-244. doi:10.2147/TCRM.S127868
Off-loading strategies in diabetic foot syndrome–evaluation of different devices
Götz, Jürgen, Lange, Mario, Dullien, Silvia, Grifka, Joachim, Hertel, Gernot, Baier, Clemens and Koeck, Franz (2017) Off-loading strategies in diabetic foot syndrome–evaluation of different devices. International Orthopaedics, 41 2: 239-246. doi:10.1007/s00264-016-3358-1
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model
Bodea, Liviu-Gabriel, Evans, Harrison Tudor, Van der Jeugd, Ann, Ittner, Lars M., Delerue, Fabien, Kril, Jillian, Halliday, Glenda, Hodges, John, Kiernan, Mathew C. and Goetz, Juergen (2017) Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell, 16 2: 377-386. doi:10.1111/acel.12565
Klinische Untersuchung des Handgelenkes und der Hand
Springorum, H. R., Baier, C., Götz, J., Schwarz, T., Benditz, A., Grifka, J. and Heers, G. (2016) Klinische Untersuchung des Handgelenkes und der Hand. Orthopade, 45 12: 1083-1098. doi:10.1007/s00132-016-3350-x
Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016) Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 10: e0164278. doi:10.1371/journal.pone.0164278
Jiao, S. -S., Shen, L. -L., Zhu, C., Bu, X. -L., Liu, Y. -H., Liu, C. -H., Yao, X. -Q., Zhang, L. -L., Zhou, H. -D., Walker, D. G., Tan, J., Goetz, J., Zhou, X. -F. and Wang, Y. -J. (2016) Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Translational Psychiatry, 6 10: e907-e907. doi:10.1038/tp.2016.186
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016) Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 6: 705-718. doi:10.1083/jcb.201512016
Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'
Brandt, Roland and Goetz, Juergen (2016) Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'. Brain Research Bulletin, 126 3: 213-216. doi:10.1016/j.brainresbull.2016.08.003
Motor cortical function determines prognosis in sporadic ALS
Shibuya, Kazumoto, Park, Susanna B., Geevasinga, Nimeshan, Menon, Parvathi, Howells, James, Simon, Neil G., Huynh, William, Noto, Yu-ichi, Gotz, Jurgen, Kril, Jillian J., Ittner, Lars M., Hodges, John, Halliday, Glenda, Vucic, Steve and Kiernan, Matthew C. (2016) Motor cortical function determines prognosis in sporadic ALS. Neurology, 87 5: 513-520. doi:10.1212/WNL.0000000000002912
Achillessehnenruptur: Aktuelle Standards in Diagnostik und Therapie
Hertel, G., Götz, J., Grifka, J. and Willers, J. (2016) Achillessehnenruptur: Aktuelle Standards in Diagnostik und Therapie. Orthopade, 45 8: 709-720. doi:10.1007/s00132-016-3287-0
Tau physiology and pathomechanisms in frontotemporal lobar degeneration
Bodea, Liviu-Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier and Götz, Juergen (2016) Tau physiology and pathomechanisms in frontotemporal lobar degeneration. Journal of Neurochemistry, 138 S1: 71-94. doi:10.1111/jnc.13600
Xia, Di, Gutmann, Julia M. and Gotz, Jurgen (2016) Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific Reports, 6 29074. doi:10.1038/srep29074
Götz, Juergen, Beckmann, Johannes, Sperrer, Ingo, Baier, Clemens, Dullien, Silvia, Grifka, Joachim and Koeck, Franz (2016) Retrospective comparative study shows no significant difference in postural stability between cruciate-retaining (CR) and cruciate-substituting (PS) total knee implant systems. International Orthopaedics, 40 7: 1441-1446. doi:10.1007/s00264-015-3067-1
Matamales, Miriam, Gotz, Jurgen and Bertran-Gonzalez, Jesus (2016) Quantitative imaging of cholinergic interneurons reveals a distinctive spatial organization and a functional gradient across the mouse striatum. PLoS One, 11 6: 1-13. doi:10.1371/journal.pone.0157682
Polanco, Juan Carlos, Scicluna, Benjamin James, Hill, Andrew Francis and Gotz, Jurgen (2016) Extracellular vesicles isolated from the brains of rTg4510 mice seed tau protein aggregation in a threshold-dependent manner. Journal of Biological Chemistry, 291 24: 12445-12466. doi:10.1074/jbc.M115.709485
Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection
Matamales, Miriam, Skrbis, Zala, Hatch, Robert J., Balleine, Bernard W., Gotz, Jurgen and Bertran-Gonzalez, Jesus (2016) Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection. Neuron, 90 2: 362-373. doi:10.1016/j.neuron.2016.03.006
Liu, Chang, Song, Xiaomin, Nisbet, Rebecca and Goetz, Juergen (2016) Co-immunoprecipitation with Tau isoform-specific antibodies reveals distinct protein interactions and highlights a putative role for 2N Tau in disease. Journal of Biological Chemistry, 291 15: 8173-8188. doi:10.1074/jbc.M115.641902
Baker, Sian and Götz, Jürgen (2016) A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathologica Communications, 4 32.1-32.13. doi:10.1186/s40478-016-0300-0
Van der Jeugd, Ann, Vermaercke, Ben, Halliday, Glenda M., Staufenbiel, Matthias and Gotz, Jürgen (2016) Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiology of Learning and Memory, 130 34-43. doi:10.1016/j.nlm.2016.01.007
Benditz, A., Völlner, F., Baier, C., Götz, J., Grifka, J. and Keshmiri, A. (2016) Schmerzverlauf nach operativer orthopädischer Intervention: Charakterisierung am Beispiel der Knieendoprothetik. Schmerz, 30 2: 181-186. doi:10.1007/s00482-015-0072-7
The frontotemporal dementia-motor neuron disease continuum
Burrell, James R., Halliday, Glenda M., Kril, Jillian J., Ittner, Lars M., Gotz, Jurgen, Kiernan, Matthew C. and Hodges, John R. (2016) The frontotemporal dementia-motor neuron disease continuum. The Lancet, 388 10047: 919-931. doi:10.1016/S0140-6736(16)00737-6
Ultrasound treatment of neurological diseases — current and emerging applications
Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016) Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 3: 161-174. doi:10.1038/nrneurol.2016.13
Operative Therapie bei rheumatoider Arthritis der Hand
Springorum, H. R., Winkler, S., Maderbacher, G., Götz, J., Baier, C., Grifka, J. and Heers, G. (2016) Operative Therapie bei rheumatoider Arthritis der Hand. Zeitschrift fur Rheumatologie, 75 1: 69-85. doi:10.1007/s00393-016-0046-x
Adulte Rückfußdeformitäten: Konservative und operative Therapie
Götz, J., Grifka, J. and Baier, C. (2016) Adulte Rückfußdeformitäten: Konservative und operative Therapie. Orthopade, 45 1: 97-110. doi:10.1007/s00132-015-3203-z
Baker, Sian, Polanco, Juan Carlos and Gotz, Juergen (2016) Extracellular vesicles containing P301L mutant tau accelerate pathological tau phosphorylation and oligomer formation but do not seed mature neurofibrillary tangles in ALZ17 mice. Journal of Alzheimer's Disease, 54 3: 1207-1217. doi:10.3233/JAD-160371
Glutamate receptors in alzheimer's disease: mechanisms and therapies
Anggono, Victor, Tsai, Li-Huei and Goetz, Juergen (2016) Glutamate receptors in alzheimer's disease: mechanisms and therapies. Neural Plasticity, 2016 8256196. doi:10.1155/2016/8256196
No full admission for tau to the exclusive prion club yet
Polanco, Juan Carlos and Götz, Jürgen (2015) No full admission for tau to the exclusive prion club yet. EMBO Journal, 34 24: 2990-2992. doi:10.15252/embj.201593311
Grimm, Amandine, Biliouris, Emily E., Lang, Undine E., Gotz, Jurgen, Mensah-Nyagan, Ayikoe Guy and Eckert, Anne (2015) Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein. Cellular and Molecular Life Sciences, 73 1: 201-215. doi:10.1007/s00018-015-1988-x
FTD and ALS—translating mouse studies into clinical trials
Ittner, Lars M., Halliday, Glenda M., Kril, Jillian J., Götz, Jürgen, Hodges, John R. and Kiernan, Matthew C. (2015) FTD and ALS—translating mouse studies into clinical trials. Nature Reviews Neurology, 11 6: 360-366. doi:10.1038/nrneurol.2015.65
Xia, Di, Li, Chuanzhou and Gotz, Jurgen (2015) Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1852 5: 913-924. doi:10.1016/j.bbadis.2014.12.017
Dementia and neurodegeneration - role of mitochondria and oxidative stress in Alzheimer's disease
Cummins, Nadia and Götz, Jurgen (2015) Dementia and neurodegeneration - role of mitochondria and oxidative stress in Alzheimer's disease. Australian Biochemist, 46 1: 4-7.
Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model
Leinenga, Gerhard and Götz, Jürgen (2015) Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 278: 278ra33.1-278ra33.12. doi:10.1126/scitranslmed.aaa2512
Chew, Yee Lian, Gotz, Jurgen and Nicholas, Hannah R. (2015) Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress. Aging Cell, 14 1: 148-151. doi:10.1111/acel.12285
What we can learn from animal models about cerebral multi-morbidity
Baker, Sian and Gotz, Jurgen (2015) What we can learn from animal models about cerebral multi-morbidity. Alzheimer's Research and Therapy, 7 11: 11. doi:10.1186/s13195-015-0097-2
Connecting the dots between tau dysfunction and neurodegeneration
Frost, Bess, Gotz, Jurgen and Feany, Mel B. (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology, 25 1: 46-53. doi:10.1016/j.tcb.2014.07.005
Handgelenksarthroskopie: Herausforderndes Verfahren der modernen Handchirurgie
Springorum, H.-Robert, Winkler, S., Maderbacher, G., Götz, J., Heers, G., Grifka, J. and Preissler, P. (2015) Handgelenksarthroskopie: Herausforderndes Verfahren der modernen Handchirurgie. Orthopade, 44 1: 89-102. doi:10.1007/s00132-014-3059-7
Tau aggregation and its interplay with amyloid-β
Nisbet, Rebecca M., Polanco, Juan-Carlos, Ittner, Lars M. and Gotz, Jurgen (2014) Tau aggregation and its interplay with amyloid-β. Acta Neuropathologica, 129 2: 207-220. doi:10.1007/s00401-014-1371-2
Kohler, Christoph, Dinekov, Maja and Gotz, Jürgen (2014) Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis. Neurobiology of Disease, 71 169-179. doi:10.1016/j.nbd.2014.07.006
Liang, Vanessa, Ullrich, Milena, Lam, Hong, Chew, Yee Lian, Banister, Samuel, Song, Xiaomin, Zaw, Thiri, Kassiou, Michael, Gotz, Jürgen and Nicholas, Hannah R. (2014) Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71 17: 3339-3361. doi:10.1007/s00018-014-1558-7
Ullrich, Milena, Liang, Vanessa, Chew, Yee Lian, Banister, Samuel, Song, Xiaomin, Zaw, Thiri, Lam, Hong, Berber, Slavica, Kassiou, Michael, Nicholas, Hannah R. and Goetz, Juergen (2014) Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9 9: 2237-2255. doi:10.1038/nprot.2014.150
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice
Ittner, Arne, Bertz, Josefine, Suh, Lisa S., Stevens, Claire H., Gotz, Jurgen and Ittner, Lars M. (2014) Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. Journal of Neurochemistry, 132 1: 1-11. doi:10.1111/jnc.12821
Chew, Yee Lian, Fan, Xiaochen, Gotz, Jurgen and Nicholas, Hannah R. (2014) Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific Reports, 4 . doi:10.1038/srep05185
Xia, Di and Gotz, Jurgen (2014) Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Frontiers in Molecular Neuroscience, 7 MAY: 1-11. doi:10.3389/fnmol.2014.00040
The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells
Chen, JinYan, Sun, MengRu, Wang, XingHua, Lu, Jing, Wei, Yan, Tan, Yan, Liu, Ying, Gotz J., He, RongQiao and Hua, Qian (2014) The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Science China Life Sciences, 57 4: 412-421. doi:10.1007/s11427-014-4643-0
Visualizing the microtubule-associated protein tau in the nucleus
Lu, Jing, Li, Ting, He, RongQiao, Bartlett, Perry F. and Gotz, Jürgen (2014) Visualizing the microtubule-associated protein tau in the nucleus. Science China Life Sciences, 57 4: 422-431. doi:10.1007/s11427-014-4635-0
Baier, C., Springorum, H. R., Maderbacher, G., Pickl, C., Grifka, J. and Götz, J. (2014) Arthrodesen bei Patienten mit rheumatisch bedingten Sprunggelenks- und Rückfußarthrosen: Eine sinnvolle Option?. Zeitschrift fur Rheumatologie, 73 9: 796-805. doi:10.1007/s00393-014-1405-0
Endoprothetische Versorgung des oberen Sprunggelenks
Götz, J., Grifka, J., Springorum, H. R., May, S. and Baier, C. (2014) Endoprothetische Versorgung des oberen Sprunggelenks. Zeitschrift fur Rheumatologie, 73 9: 788-795. doi:10.1007/s00393-014-1404-1
Weil Osteotomy - a critical Review Weil-Osteotomie - "Critical Review"
Götz, Jürgen, Grifka, Joachim and Baier, Clemens (2014) Weil Osteotomy - a critical Review Weil-Osteotomie - "Critical Review". Fuss und Sprunggelenk, 12 4: 200-207. doi:10.1016/j.fuspru.2014.10.005
Liu, Chang and Goetz, Juergen (2013) Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PloS One, 8 12: e84849. doi:10.1371/journal.pone.0084849
Eckert, Anne, Nisbet, Rebecca, Grimm, Amandine and Götz, Jürgen (2013) March separate, strike together: role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1842 8: 1258-1266. doi:10.1016/j.bbadis.2013.08.013
Aging in the nervous system of Caenorhabditis elegans
Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) Aging in the nervous system of Caenorhabditis elegans. Communicative and Integrative Biology, 6 5: e25288.1-e25288.6. doi:10.4161/cib.25288
Lessons from two prevalent amyloidoses-what amylin and A beta have in common
Goetz, Juergen, Lim, Yun-An and Eckert, Anne (2013) Lessons from two prevalent amyloidoses-what amylin and A beta have in common. Frontiers in Aging Neuroscience, 5 AUG: 38.1-38.9. doi:10.3389/fnagi.2013.00038
Heers, G., Springorum, H. R., Baier, C., Götz, J., Grifka, J. and Renkawitz, T. (2013) Proximal interphalangeal joint replacement with an unconstrained pyrocarbon prosthesis (Ascension®): a long-term follow-up. Journal of Hand Surgery: European Volume, 38 6: 680-685. doi:10.1177/1753193412469898
Goetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013) What renders TAU toxic. Frontiers in Neurology, 4 72.1-72.10. doi:10.3389/fneur.2013.00072
Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot
Baier, Clemens, Schaumburger, Jens, Götz, Jürgen, Heers, Guido, Schmidt, Thorsten, Grifka, Joachim and Beckmann, Johannes (2013) Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot. Rheumatology International, 33 6: 1397-1402. doi:10.1007/s00296-012-2584-0
Why size matters - balancing mitochondrial dynamics in Alzheimer's disease
DuBoff, Brian, Feany, Mel and Goetz, Juergen (2013) Why size matters - balancing mitochondrial dynamics in Alzheimer's disease. Trends in Neurosciences, 36 6: 325-335. doi:10.1016/j.tins.2013.03.002
Koehler, Christoph, Dinekov, Maja and Goetz, Juergen (2013) Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiology of Aging, 34 5: 1369-1379. doi:10.1016/j.neurobiolaging.2012.11.010
Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation
Nilsen, Linn Hege, Rae, Caroline, Ittner, Lars M., Goetz, Juergen and Sonnewald, Ursula (2013) Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism, 33 5: 684-691. doi:10.1038/jcbfm.2012.212
PTL-1 regulates neuronal integrity and lifespan in C-elegans
Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) PTL-1 regulates neuronal integrity and lifespan in C-elegans. Journal of Cell Science, 126 9: 2079-2091. doi:10.1242/jcs.jcs124404
Baier, Clemens, Springorum, Hans-Robert, Götz, Jürgen, Schaumburger, Jens, Lüring, Christian, Grifka, Joachim and Beckmann, Johannes (2013) Comparing navigation-based in vivo knee kinematics pre- and postoperatively between a cruciate-retaining and a cruciate-substituting implant. International Orthopaedics, 37 3: 407-414. doi:10.1007/s00264-013-1798-4
Das Knochenmarködemsyndrom (KMÖS)
Craiovan, B. S., Baier, C., Grifka, J., Götz, J., Schaumburger, J. and Beckmann, J. (2013) Das Knochenmarködemsyndrom (KMÖS). Orthopade, 42 3: 191-204. doi:10.1007/s00132-012-2053-1
Morcinek, Kerstin, Köhler, Christoph, Goetz, Juergen and Schröder, Hannsjorg (2013) Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Research, 1497 73-84. doi:10.1016/j.brainres.2012.12.016
Götz, J., Grifka, J. and Baier, C. (2013) Die Behandlung des kindlichen Knick-Senk-Fußes durch Schuheinlagen: Eine wissenschaftlich fundierte Therapie?. Orthopade, 42 1: 6-11. doi:10.1007/s00132-012-1985-9
How it all started: Tau and protein phosphatase 2A
Liu, Chang and Goetz, Juergen (2013) How it all started: Tau and protein phosphatase 2A. Journal of Alzheimer's Disease, 37 3: 483-494. doi:10.3233/jad-130503
Delerue, Fabien, Sjollema, Geoff, Whittle, Belinda, Krueger, Sarah, Andrews, Dan and Goetz, Juergen (2013) Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition. Journal of Alzheimers Disease, 36 2: 349-363. doi:10.3233/JAD-130089
Decoding the non-coding RNAs in Alzheimer's disease
Schonrock, Nicole and Goetz, Juergen (2012) Decoding the non-coding RNAs in Alzheimer's disease. Cellular and Molecular Life Sciences, 69 21: 3543-3559. doi:10.1007/s00018-012-1125-z
Nachbehandlungsstrategien nach rheumaorthopädischen Operationen an der Schulter: Ein Vorschlag
Heers, G., Grifka, J. and Götz, J. (2012) Nachbehandlungsstrategien nach rheumaorthopädischen Operationen an der Schulter: Ein Vorschlag. Zeitschrift fur Rheumatologie, 71 8: 650-657. doi:10.1007/s00393-012-1028-2
Orthopädische Operationen und Nachbehandlungsregimes am rheumatischen Ellenbogen
Götz, J., Baier, C., Springorum, H. R., Anders, S., Grifka, J. and Heers, G. (2012) Orthopädische Operationen und Nachbehandlungsregimes am rheumatischen Ellenbogen. Zeitschrift fur Rheumatologie, 71 8: 658-669. doi:10.1007/s00393-012-1019-3
Tau promotes neurodegeneration via DRP1 mislocalization in vivo
DuBoff, Brian, Goetz, Juergen and Feany, Mel B. (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron, 75 4: 618-632. doi:10.1016/j.neuron.2012.06.026
Alzheimer's disease models and functional genomics-how many needles are there in the haystack?
Goetz, Juergen, Matamales, Miriam, Goetz, Naeman N., Ittner, Lars M. and Eckert, Anne (2012) Alzheimer's disease models and functional genomics-how many needles are there in the haystack?. Frontiers in Physiology, 3 320: 320.1-320.14. doi:10.3389/fphys.2012.00320
Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship
Grimm, Amandine, Lim, Yun-An, Mensah-Nyagan, Ayikoe Guy, Goetz, Jurgen and Eckert, Anne (2012) Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship. Molecular Neurobiology, 46 1: 151-160. doi:10.1007/s12035-012-8281-x
MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease
Schonrock, Nicole, Matamales, Miriam, Ittner, Lars M. and Gotz, Juergen (2012) MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease. Experimental Neurology, 235 2: 447-454. doi:10.1016/j.expneurol.2011.11.013
Akutes leberversagen nach pilzingestion
Oeckinghaus, R., Cuneo, A., Brockmeier, J., Oeckinghaus, G. S., Drewek-Platena, S., Hochreuther, St, Götz, J. and Tebbe, U. (2012) Akutes leberversagen nach pilzingestion. Internist, 53 5: 619-624. doi:10.1007/s00108-011-3008-z
Ke, Yazi, Dramiga, Joe, Schütz, Ulrich, Kril, Jillian J., Ittner, Lars M., Schröder, Hannsjörg and Götz, Jürgen (2012) Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PloS One, 7 4: 1-8. doi:10.1371/journal.pone.0035678
Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio
Schmitt, Karen, Grimm, Amandine, Kazmierczak, Anna, Strosznajder, Joanna B., Gotz, Jurgen and Eckert, Anne (2012) Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio. Antioxidants and Redox Signaling, 16 12: 1456-1466. doi:10.1089/ars.2011.4400
A neuroprotective role for the DNA damage checkpoint in tauopathy
Khurana, Vikram, Merlo, Paola, DuBoff, Brian, Fulga, Tudor A., Sharp, Katherine A., Campbell, Shelagh D., Goetz, Juergen and Feany, Mel B. (2012) A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell, 11 2: 360-362. doi:10.1111/j.1474-9726.2011.00778.x
Tau-targeted treatment strategies in Alzheimer's disease
Gotz, Jurgen, Ittner, Arne and Ittner, Lars M. (2012) Tau-targeted treatment strategies in Alzheimer's disease. British Journal of Pharmacology, 165 5: 1246-1259. doi:10.1111/j.1476-5381.2011.01713.x
Role of hippocalcin in mediating Aβ toxicity
Lim, Yun-An, Giese, Maria, Shepherd, Claire, Halliday, Glenda, Kobayashi, Masaaki, Takamatsu, Ken, Staufenbiel, Matthias, Eckert, Anne and Gotz, Jürgen (2012) Role of hippocalcin in mediating Aβ toxicity. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1822 8: 1247-1257. doi:10.1016/j.bbadis.2012.04.007
Schonrock, Nicole, Humphreys, David T., Preiss, Thomas and Gotz, Jürgen (2012) Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.. Journal of Molecular Neuroscience, 46 2: 324-335. doi:10.1007/s12031-011-9587-2
Alzheimer's disease selective vulnerability and modelling in transgenic mice
Götz, Jürgen, Schonrock, Nicole, Vissel, Bryce and Ittner, Lars M. (2011) Alzheimer's disease selective vulnerability and modelling in transgenic mice. Advances in Alzheimer's Disease, 1 49-58. doi:10.3233/978-1-60750-733-8-49
Lim, Yun-An, Grimm, Amandine, Giese, Maria, Mensah-Nyagan, Ayikoe Guy, Villafranca, J. Ernest, Ittner, Lars M., Eckert, Anne and Gotz, Jurgen (2011) Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS ONE, 6 12: e28887.1-e28887.12. doi:10.1371/journal.pone.0028887
Bi, Mian, Ittner, Arne, Ke, Yazi D., Gotz, Jurgen and Ittner, Lars M. (2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS ONE, 6 12: e26860.1-e26860.7. doi:10.1371/journal.pone.0026860
Köck, F. X., Beckmann, J., Lechler, P., Götz, J., Schaumburger, J. and Grifka, J. (2011) The 2-year follow-up results of a patient-specific interpositional knee implant Zwei-Jahres-Resultate mit einem patientenspezifischen metallischen Knieinterpositionsimplantat. Orthopade, 40 12: 1103-1110. doi:10.1007/s00132-011-1790-x
Götz, J., Grifka, J. and Handel, M. (2011) Hallux rigidus. Der Orthopäde, 40 9: 819-834. doi:10.1007/s00132-011-1815-5
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
van Eersel, Janet, Ke, Yazi D., Gladbach, Amadeus, Bi, Mian, Gotz, Jurgen, Kril, Jillian J. and Ittner, Lars M. (2011) Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS ONE, 6 7: e22850.1-e22850.13. doi:10.1371/journal.pone.0022850
Eckert, Anne, Schmitt, Karen and Gotz, Jurgen (2011) Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity. Alzheimer's Research and Therapy, 3 3: 15.1-15.11. doi:10.1186/alzrt74
Louis, Justin V., Martens, Ellen, Borghgraef, Peter, Lambrecht, Caroline, Sents, Ward, Longin, Sari, Zwaenepoel, Karen, Pijnenborg, Robert, Landrieu, Isabelle, Lippens, Guy, Ledermann, Birgit, Gotz, Jürgen, Van Leuven, Fred, Goris, Jozef and Janssens, Veerle (2011) Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β. Proceedings of the National Academy of Sciences of the United States of America, 108 17: 6957-6962. doi:10.1073/pnas.1018777108
Soutodeh, Roja, Götz, Jürgen, Tebbe, Ulrich and Cuneo, Alessandro (2011) Acquired long QT interval in a recurrent septic female patient with polymorphic ventricular tachycardia due to primary acute adrenal insufficiency. Clinical Research in Cardiology, 100 4: 373-377. doi:10.1007/s00392-010-0257-0
Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation
Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. and Brandt, R. (2011) Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging, 32 6: 991-1006. doi:10.1016/j.neurobiolaging.2009.06.007
Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease
Ittner, Lars M. and Gotz, Jürgen (2011) Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease. Nature Reviews Neuroscience, 12 2: 67-72. doi:10.1038/nrn2967
Brief update on different roles of tau in neurodegeneration
Ittner, Arne, Ke, Yazi D., van Eersel, Janet, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2011) Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63 7: 495-502. doi:10.1002/iub.467
Liu, Xin, Dobbie, Michael, Tunningley, Rob, Whittle, Belinda, Zhang, Yafei, Ittner, Lars M. and Gotz, Jurgen (2011) ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. Journal of Biomedicine and Biotechnology, 2011 130947.1-130947.11. doi:10.1155/2011/130947
Invertebrate and Vertebrate Models of Tauopathies
Goetz, Juergen, Ittner, Lars M., Goetz, Naeman N., Lam, Hong and Nicholas, Hannah R. (2011) Invertebrate and Vertebrate Models of Tauopathies. Animal Models for Neurodegenerative Disease, 6: 69-85. doi:10.1039/9781849732758
Modes of Aβ toxicity in Alzheimer's disease
Gotz, Jurgen, Eckert, Anne, Matamales, Miriam, Ittner, Lars M. and Liu, Xin (2011) Modes of Aβ toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68 20: 3359-3375. doi:10.1007/s00018-011-0750-2
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice
Attems, Johannes, Ittner, Arne, Jellinger, Kurt, Nitsch, Roger M., Maj, Magdalena, Wagner, Ludwig, Gotz, Jurgen and Heikenwalder, Mathias (2011) Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of Neural Transmission, 118 5: 737-745. doi:10.1007/s00702-011-0626-5
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy
Kohler, C., Bista, P., Gotz, J. and Schroder, H. (2010) Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Research, 1347 111-124. doi:10.1016/j.brainres.2010.05.076
van Eersel, Janet, Ke, Yazi D., Liu, Xin, Delerue, Fabien, Kril, Jillian J., Gotz, Jürgen and Ittner, Lars M. (2010) Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America, 107 31: 13888-13893. doi:10.1073/pnas.1009038107
Convergence of amyloid-β and tau pathologies on mitochondria in vivo
Eckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Gotz, Jürgen (2010) Convergence of amyloid-β and tau pathologies on mitochondria in vivo. Molecular Neurobiology, 41 2-3: 107-114. doi:10.1007/s12035-010-8109-5
Neuronal microrna deregulation in response to Alzheimer's disease amyloid-β
Schonrock, Nicole, Ke, Yazi D., Humphreys, David, Staufenbiel, Matthias, Ittner, Lars M., Preiss, Thomas and Gotz, Jurgen (2010) Neuronal microrna deregulation in response to Alzheimer's disease amyloid-β. PLoS ONE, 5 6: e11070.1-e11070.11. doi:10.1371/journal.pone.0011070
Götz, J., Beckmann, J., Rath, B., Lüring, C., Dullien, S. and Grifka, J. (2010) Gait kinematics of patients after total hip replacement -influence of two different gait velocities on determining pathological findings Gangkinematik von Patienten nach hüftendoprothetischer Versorgung -Einfluss von zwei unterschiedlichen Ganggeschwindigkeiten auf das Erkennen von Gangpathologien. Physikalische Medizin Rehabilitationsmedizin Kurortmedizin, 20 2: 71-75. doi:10.1055/s-0029-1241887
Dissecting Toxicity of Tau and β-Amyloid
Gotz, Jurgen, Lim, Yun-An, Ke, Yazi D., Eckert, Anne and Ittner, Lars M. (2010) Dissecting Toxicity of Tau and β-Amyloid. Neurodegenerative Diseases, 7 1-3: 10-12. doi:10.1159/000283475
Animal models reveal role for tau phosphorylation in human disease
Gotz, Jurgen, Gladbach, Amadeus, Pennanen, Luis, van Eersel, Janet, Schild, Andreas, David, Della and Ittner, Lars M. (2010) Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 10: 860-871. doi:10.1016/j.bbadis.2009.09.008
Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction
Lim, Yun-An, Rhein, Virginie, Baysang, Ginette, Meier, Fides, Poljak, Anne, Raftery, Mark J., Guilhaus, Michael, Ittner, Lars M., Eckert, Anne and Gotz, Jürgen (2010) Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics, 10 8: 1621-1633. doi:10.1002/pmic.200900651
Hochreuther, S., Cuneo, A., Härtel, D., Brockmeier, J., Götz, J. and Tebbe, U. (2010) Central anticholinergic syndrome: Accidental poisoning from angel's trumpet - a case report Zentral anticholinerges Syndrom: Akzidentelle Vergiftung mit Engelstrompete - ein Fallbericht. Intensivmedizin und Notfallmedizin, 47 3: 211-214. doi:10.1007/s00390-009-0068-6
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
Ittner, Lars M., Ke, Yazi D., Delerue, Fabien, Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Wolfing, Heidrun, Chieng, Billy C., Christie, MacDonald J., Napier, Ian A., Eckert, Anne, Staufenbiel, Matthias, Hardeman, Edna and Gotz, Jurgen (2010) Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell, 142 3: 387-397. doi:10.1016/j.cell.2010.06.036
Krupka, Niklas, Strappe, Padraig, Gotz, Jürgen and Ittner, Lars M. (2010) Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid, 63 3: 155-160. doi:10.1016/j.plasmid.2010.01.002
Parkinson's disease: insights from non-traditional model organisms
Pienaar, Ilse S., Gotz, Jürgen and Feany, Mel B. (2010) Parkinson's disease: insights from non-traditional model organisms. Progress in Neurobiology, 92 4: 558-571. doi:10.1016/j.pneurobio.2010.09.001
Animal models for Alzheimer's disease and frontotemporal dementia: A perspective
Götz, Jürgen and Götz, Naeman N. (2009) Animal models for Alzheimer's disease and frontotemporal dementia: A perspective. ASN Neuro, 1 4: 251-264. doi:10.1042/AN20090042
Rhein, Virginie, Song, Xiaomin, Wiesner, Andreas, Ittner, Lars M., Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Drose, Stefan, Brandt, Ulrich, Savaskan, Egemen, Czech, Christian, Gotz, Jurgen and Eckert, Anne (2009) Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America, 106 47: 20057-20062. doi:10.1073/pnas.0905529106
Ke, Yazi D., Delerue, Fabien, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2009) Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS ONE, 4 11: e7917.1-e7917.7. doi:10.1371/journal.pone.0007917
Götz, Jürgen, Ittner, Lars M. and Lim, Yun-An (2009) Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences, 66 17: . doi:10.1007/s00018-009-0073-8
Ittner, Lars M., Ke, Yazi D. and Gotz, Jurgen (2009) Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. Journal of Biological Chemistry, 284 31: 20909-20916. doi:10.1074/jbc.M109.014472
Baier, C., Götz, J., Rümmele, P., Grifka, J. and Lüring, C. (2009) Ochronosis--a rare cause of secondary gonarthrosis Ochronose--eine seltene Ursache der sekundären Gonarthrose. Zeitschrift für Orthopädie und Unfallchirurgie, 147 3: 366-368.
Common features between diabetes mellitus and Alzheimer's disease
Götz, J., Ittner, L. M. and Lim, Y. A. (2009) Common features between diabetes mellitus and Alzheimer's disease. Cellular and Molecular Life Sciences, 66 8: 1321-1325. doi:10.1007/s00018-009-9070-1
Substrate-specific reduction of PP2A activity exaggerates tau pathology
Deters, Natasha, Ittner, Lars M. and Gotz, Jurgen (2009) Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and Biophysical Research Communications, 379 2: 400-405. doi:10.1016/j.bbrc.2008.12.140
Alzheimer's disease selective vulnerability and modeling in transgenic Mice
Gotz, Jurgen, Schonrock, Nicole, Vissel, Bryce and Ittner, Lars M. (2009) Alzheimer's disease selective vulnerability and modeling in transgenic Mice. Journal of Alzheimer's Disease, 18 2: 243-251. doi:10.3233/JAD-2009-1143
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
van Eersel, Janet, Bi, Mian, Ke, Yazi D., Hodges, John R., Xuereb, John H., Gregory, Gillian C., Halliday, Glenda M., Gotz, Jurgen, Kril, Jillian J. and Ittner, Lars M. (2009) Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission, 116 10: 1243-1251. doi:10.1007/s00702-009-0293-y
Primary support cultures of hippocampal and substantia nigra neurons
Fath, Thomas, Ke, Yazi D., Gunning, Peter, Gotz, Jürgen and Ittner, Lars M. (2009) Primary support cultures of hippocampal and substantia nigra neurons. Nature Protocols, 4 1: 78-85. doi:10.1038/nprot.2008.199
An update on the toxicity of A-beta in Alzheimer's disease
Götz, Jurgen, Ittner, Lars M, Schonrock, Nicole and Cappai, Roberto (2008) An update on the toxicity of A-beta in Alzheimer's disease. Neuropsychiatric Disease and Treatment, 4 6: 1033-1042. doi:10.2147/NDT.S3016
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
Ittner, Lars M., Fath, Thomas, Ke, Yazi D., Bi, Mian, van Eersel, Janet, Li, Kong M., Gunning, Peter and Gotz, Jurgen (2008) Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America, 105 41: 15997-16002. doi:10.1073/pnas.0808084105
Lim, Yun-An, Ittner, Lars M., Lim, Yun Li and Gotz, Jürgen (2008) Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures. FEBS Letters, 582 15: 2188-2194. doi:10.1016/j.febslet.2008.05.006
Baur, Karen, Rauer, Mathias, Richter, Kirsten, Pagenstecher, Axel, Gotz, Jurgen, Hausmann, Jurgen and Staeheli, Peter (2008) Antiviral CD8 T cells recognize Borna disease virus antigen transgenically expressed in either neurons or astrocytes. Journal of Virology, 82 6: 3099-3108. doi:10.1128/JVI.02479-07
Gotz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y.-A., Deters, N. and Ittner, L. M. (2008) Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegenerative Diseases, 5 3-4: 179-181. doi:10.1159/000113696
Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Rhein, Virginie, Muller-Spahn, Franz, Gotz, Jürgen and Muller, Walter E. (2008) Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegenerative Diseases, 5 3-4: 157-159. doi:10.1159/000113689
Animal models of Alzheimer's disease and frontotemporal dementia
Gotz, Jurgen and Ittner, Lars M. (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews Neuroscience, 9 7: 532-544. doi:10.1038/nrn2420
Divergent phosphorylation pattern of tau in P301L tau transgenic mice
Deters, Natasha, Ittner, Lars M. and Gotz, Jurgen (2008) Divergent phosphorylation pattern of tau in P301L tau transgenic mice. European Journal of Neuroscience, 28 1: 137-147. doi:10.1111/j.1460-9568.2008.06318.x
Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?
Goetz, Juergen, Ittner, Lars M., Faendrich, Marcus and Schonrock, Nicole (2008) Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?. Journal of Alzheimers Disease, 14 4: 423-429. doi:10.3233/JAD-2008-14410
Neuroproteomics as a promising tool in Parkinson's disease research
Pienaar, Ilse S., Daniels, William M. U. and Gotz, Jurgen (2008) Neuroproteomics as a promising tool in Parkinson's disease research. Journal of Neural Transmission, 115 10: 1413-1430. doi:10.1007/s00702-008-0070-3
Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Meinhardt, Jessica, Rhein, Virginie, Drose, Stefan, Brandt, Ulrich, Fandrich, Marcus, Muller, Walter E. and Gotz, Jürgen (2008) Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice. Journal of Molecular Medicine, 86 11: 1255-1267. doi:10.1007/s00109-008-0391-6
Ittner, Lars M., Schwerdtfeger, Kerstin, Kunz, Thomas H., Muff, Roman, Husmann, Knut, Grimm, Christian, Hafezi, Farhad, Langh, Karl S., Kurrer, Michael O., Gotz, Jurgen, Born, Walter and Fischer, Jan A. (2008) Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical Science, 114 1-2: 49-58. doi:10.1042/CS20070163
Habicht G., Haupt C., Friedrich R.P., Hortschansky P., Sachse C., Meinhardt J., Wieligmann K., Gellermann G.P., Brodhun M., Gotz J., Halbhuber K.-J., Rocken C., Horn U. and Fandrich M. (2007) Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils. Proceedings of the National Academy of Sciences of the United States of America, 104 49: 19232-19237. doi:10.1073/pnas.0703793104
Hoerndli, Frederic J., Pelech, Steven, Papassotiropoulos, Andreas and Gotz, Juergen (2007) Aβ treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. European Journal of Neuroscience, 26 1: 60-72. doi:10.1111/j.1460-9568.2007.05618.x
Possibilities for the prevention and treatment of cognitive impairment and dementia
Burke, David, Hickie, Ian, Breakspear, Michael and Gotz, Juergen (2007) Possibilities for the prevention and treatment of cognitive impairment and dementia. British Journal of Psychiatry, 190 5: 371-372. doi:10.1192/bjp.bp.106.033407
Götz, Jürgen, Beckmann, J., Perlick, L., Handel, M. and Grifka, J. (2007) Loosening of a total hip arthroplasty due to metastasis Metastatisch bedingte lockerung einer hüfttotalendoprothese. Zeitschrift fur Orthopadie und Unfallchirurgie, 145 6: 760-762. doi:10.1055/s-2007-989300
Heers, Guido, Götz, Jürgen, Schubert, Thomas, Schachner, Henrik, Neumaier, Ulrich, Grifka, Joachim and Hedtmann, Achim (2007) MR imaging of the intraarticular disk of the acromioclavicular joint: A comparison with anatomical, histological and in-vivo findings. Skeletal Radiology, 36 1: 23-28. doi:10.1007/s00256-006-0181-6
Pronuclear injection for the production of transgenic mice
Ittner, Lars M. and Gotz, Juergen (2007) Pronuclear injection for the production of transgenic mice. Nature Protocols, 2 5: 1206-1215. doi:10.1038/nprot.2007.145
Heers, Guido, Götz, J., Anders, S., Grifka, J. and Hedtmann, A. (2006) Ultrasound evaluation of the acromioclavicular joint - A correlation of anatomical and sonographical findings Sonometrie des akromioklavikulargelenkes - Korrelation anatomischer und sonographischer befunde. Ultraschall in der Medizin, 27 6: 549-552. doi:10.1055/s-2005-858946
David, Della C., Ittner, Lars M., Gehrig, Peter, Nergenau, Denise, Shepherd, Claire, Halliday, Glenda and Gotz, Juergen (2006) β-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics, 6 24: 6566-6577. doi:10.1002/pmic.200600634
Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation
Schild, Andreas, Schmidt, Karsten, Lim, Yun-An, Ke, Yazi, Ittner, Lars M., Hemmings, Brian A. and Gotz, Juergen (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International Journal of Developmental Neuroscience, 24 7: 437-443. doi:10.1016/j.ijdevneu.2006.08.005
Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?
Goetz, Juergen, Ittner, Lars M. and Schonrock, Nicole (2006) Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?. Medical Journal of Australia, 185 7: 381-384.
Härtel, D., Christel, E., Brockmeier, J., Cuneo, A., Zellerhoff, C., Götz, J., Hundhausen, T., Dammann, T. and Tebbe, U. (2006) Improvement of patient's therapy with acute coronary syndrome in rural areas: Importance of a medical network Verbesserung der Behandlung von Patienten mit akutem Koronarsyndrom durch Aufbau einer Netzwerkstruktur im ländlichen Raum. Notfall und Rettungsmedizin, 10 6: 423-431. doi:10.1007/s10049-007-0938-z
Götz, Jürgen, Ittner, Lars M. and Kins, Stefan (2006) Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?. Journal of Neurochemistry, 98 4: 993-1006. doi:10.1111/j.1471-4159.2006.03955.x
Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice
Pennanen, L., Wolfer, D. P., Nitsch, R. M. and Gotz, J. (2006) Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, Brain and Behavior, 5 5: 369-379. doi:10.1111/j.1601-183X.2005.00165.x
Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice
Schild, Andreas, Ittner, Lars M. and Gotz, Juergen (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and Biophysical Research Communications, 343 4: 1171-1178. doi:10.1016/j.bbrc.2006.03.066
Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice
Schild, Andreas, Isenmann, Stefan, Tanimoto, Naoyuki, Tonagel, Felix, Seeliger, Mathias W., Ittner, Lars M., Kretz, Alexandra, Ogris, Egon and Gotz, Juergen (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of Development, 123 5: 362-371. doi:10.1016/j.mod.2006.03.003
Active immunization trial in Aβ42-injected P301L tau transgenic mice
Kulic, Luka, Kurosinski, Pascal, Chen, Feng, Tracy, Jay, Mohajeri, M. Hasan, Li, Hong, Nitsch, Roger M. and Gotz, Juergen (2006) Active immunization trial in Aβ42-injected P301L tau transgenic mice. Neurobiology of Disease, 22 1: 50-56. doi:10.1016/j.nbd.2005.10.002
Tam, CW, Husmann, K, Clark, NC, Clark, JE, Lazar, Z, Ittner, LM, Gotz, J, Douglas, G, Grant, AD, Sugden, D, Poston, L, Poston, R, McFadzean, I, Marber, MS, Fischer, JA, Born, W and Brain, SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2. Circulation Research, 98 2: 262-270. doi:10.1161/01.RES.0000200737.638.65.58
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei, Jin-Jing, An, Wen-Lin, Zhou, Xin-Wen, Nishimura, Takeshi, Norberg, Jan, Benedikz, Eirikur, Gotz, Juergen and Winblad, Bengt (2006) P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Letters, 580 1: 107-114. doi:10.1016/j.febslet.2005.11.059
Different tau epitopes define Aβ42-mediated tau insolubility
Pennanen, Luis and Gotz, Juergen (2005) Different tau epitopes define Aβ42-mediated tau insolubility. Biochemical and Biophysical Research Communications, 337 4: 1097-1101. doi:10.1016/j.bbrc.2005.09.168
Heers, G., Götz, J., Schachner, H., Neumaier, U., Grifka, J. and Hedtmann, A. (2005) Ultrasound evaluation of the acromioclavicular joint. A comparison with magnetic resonance imaging Wertigkeit der ultraschalldiagnostik des acromioclaviculargelenks. Ein vergleich mit kernspintomografischen messungen. Sportverletzung-Sportschaden, 19 4: 177-181. doi:10.1055/s-2005-858871
Beckmann, J., Götz, J., Grifka, J. and Borisch, N. (2005) Necrosis of the carpal scaphoid after chemotherapy. Case report Skaphoidnekrose nach chemotherapie: Fallbericht. Orthopade, 34 9: 938-940. doi:10.1007/s00132-005-0819-4
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
David, Della C., Hauptmann, Susanne, Scherping, Isabel, Schuessel, Katrin, Keil, Uta, Rizzu, Patrizia, Ravid, Rivka, Drose, Stefan, Brandt, Ulrich, Muller, Walter E., Eckert, Anne and Gotz, Juergen (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. Journal of Biological Chemistry, 280 25: 23802-23814. doi:10.1074/jbc.M500356200
David, Della C., Hoerndli, Frederic and Gotz, Juergen (2005) Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology. Progress in Neurobiology, 76 3: 153-168. doi:10.1016/j.pneurobio.2005.07.001
Functional genomics meets neurodegenerative disorders: part II: application and data integration
Hoerndli, Frederic, David, Della C. and Gotz, Juergen (2005) Functional genomics meets neurodegenerative disorders: part II: application and data integration. Progress in Neurobiology, 76 3: 169-188. doi:10.1016/j.pneurobio.2005.07.002
Role of the protein tau in Alzheimer's disease
Götz, Jürgen, Ittner, Lars M. and David, Della C. (2005) Role of the protein tau in Alzheimer's disease. Drug Discovery Today: Disease Mechanisms, 2 4: 395-400. doi:10.1016/j.ddmec.2005.11.008
Hoerndli, Frédéric J., Toigo, Marco, Schild, Andreas, Gotz, Jürgen and Day, Philip J. (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Analytical Biochemistry, 335 1: 30-41. doi:10.1016/j.ab.2004.08.028
Gotz, Juergen, Schild, Andreas, Hoerndli, Fred and Pennanen, Luis (2004) Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. International Journal of Developmental Neuroscience, 22 7: 453-465. doi:10.1016/j.ijdevneu.2004.07.013
Gotz, J, Streffer, JR, David, D, Schild, A, Hoerndli, F, Pennanen, L, Kurosinski, P and Chen, F (2004) Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy. Molecular Psychiatry, 9 7: 664-683. doi:10.1038/sj.mp.4001508
Role for glyoxalase I in Alzheimer's disease
Chen, Feng, Wollmer, M. Axel, Hoerndli, Frederic, Munch, Gerald, Kuhla, Bjorn, Rogaev, Evgeny I., Tsolaki, Magdalini, Papassotiropoulos, Andreas and Gotz, Juergen (2004) Role for glyoxalase I in Alzheimer's disease. National Academy of Sciences. Proceedings, 101 20: 7687-7692. doi:10.1073/pnas.0402338101
Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
Pennanen, Luis, Welzl, Hans, D'Adamo, Patrizia, Nitsch, Roger M. and Gotz, Juergen (2004) Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of Disease, 15 3: 500-509. doi:10.1016/j.nbd.2003.11.020
Martens, Ellen, Stevens, Ilse, Janssens, Veerle, Vermeesch, Joris, Gotz, Juergen, Goris, Jozef and Van Hoof , Christine Van (2004) Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice. Journal of Molecular Biology, 336 4: 971-986. doi:10.1016/j.jmb.2003.12.047
Chen F., David D., Ferrari A. and Gotz J. (2004) Posttranslational modifications of tau - Role in human tauopathies and modeling in transgenic animals. Current Drug Targets, 5 6: 503-515. doi:10.2174/1389450043345236
Rauer, Mathias, Gotz, Jurgen, Schuppli, Daniel, Staeheli, Peter and Hausmann, Jurgen (2004) Transgenic Mice Expressing the Nucleoprotein of Borna Disease Virus in either Neurons or Astrocytes: Decreased Susceptibility to Homotypic Infection and Disease. Journal of Virology, 78 7: 3621-3632. doi:10.1128/JVI.78.7.3621-3632.2004
β-amyloid induces paired helical filament-like tau filaments in tissue culture
Ferrari, Alessandra, Hoerndli, Frederic, Baechi, Thomas, Nitsch, Roger M. and Gotz, Juergen (2003) β-amyloid induces paired helical filament-like tau filaments in tissue culture. Journal of Biological Chemistry, 278 41: 40162-40168. doi:10.1074/jbc.M308243200
Kins, S, Kurosinski, P, Nitsch, RM and Gotz, J (2003) Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. American Journal of Pathology, 163 3: 833-843. doi:10.1016/S0002-9440(10)63444-X
Flechsig, Eckhard, Hegyi, Ivan, Leimeroth, Rainer, Zuniga, Armando, Rossi, Daniela, Cozzio, Antonio, Schwarz, Petra, Rulicke, Thomas, Gotz, Juergen, Aguzzi, Adriano and Weissmann, Charles (2003) Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. EMBO Journal, 22 12: 3095-3101. doi:10.1093/emboj/cdg285
Saitohin gene is not associated with Alzheimer's disease
Streffer, J. R., Papassotiropoulos, A., Kurosinski, P., Signorell, A., Wollmer, M. A., Tsolaki, M., Iakovidou, V., Horndli, F., Bosset, J., Gotz, J., Nitsch, R. M. and Hock, C. (2003) Saitohin gene is not associated with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 74 3: 362-363. doi:10.1136/jnnp.74.3.362
Protein Phosphatases: Transgenic and knockout models of PP2A
Gotz, J. and Schild, A. (2003) Protein Phosphatases: Transgenic and knockout models of PP2A. Methods in Enzymology, 366 390-403. doi:10.1016/S0076-6879(03)66029-5
Schmidt, Karsten, Kins, Stefan, Schild, Andreas, Nitsch, Roger M., Hemmings, Brian A. and Gotz, Juergen (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. European Journal of Neuroscience, 16 11: 2039-2048. doi:10.1046/j.1460-9568.2002.02274.x
Glial cells under physiologic and pathologic conditions
Kurosinski, Pascal, Biol, Dipl and Gotz, Jurgen (2002) Glial cells under physiologic and pathologic conditions. JAMA Neurology, 59 10: 1524-1528. doi:10.1001/archneur.59.10.1524
Neurofibrillary tangle formation in transgenic mouse models of Alzheimer's disease
Chen, F, Nitsch, RM, Gotz, J, van Dorpe, J and Leuven, KU (2002) Neurofibrillary tangle formation in transgenic mouse models of Alzheimer's disease. Neurobiology of Aging, 23 1: S233-S233.
Alzheimer's and Parkinson's disease - overlapping or synergistic pathologies?
Kurosinski, P, Guggisberg, M and Gotz, J (2002) Alzheimer's and Parkinson's disease - overlapping or synergistic pathologies?. Trends in Molecular Medicine, 8 1: 3-5. doi:10.1016/S1471-4914(01)02246-8
Kins, Stefan, Crameri, Arames, Evans, David R. H., Hemmings, Brian A., Nitsch, Roger M. and Gotz, Juergen (2001) Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. Journal of Biological Chemistry, 276 41: 38193-38200.
Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
Goetz, J., Chen, F., Van Dorpe, J. and Nitsch, R. M. (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science, 293 5534: 1491-1495. doi:10.1126/science.1062097
Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice
Gotz, J and Nitsch, RM (2001) Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. Neuroreport, 12 9: 2007-2016.
Tau and transgenic animal models
Gotz, J (2001) Tau and transgenic animal models. Brain Research Reviews, 35 3: 266-286. doi:10.1016/S0165-0173(01)00055-8
Human tau transgenic mice - Towards an animal model for neuro- and glialfibrillary lesion formation
Gotz, J, Tolnay, M, Barmettler, R, Ferrari, A, Burki, K, Goedert, M, Probst, A and Nitsch, RM (2001) Human tau transgenic mice - Towards an animal model for neuro- and glialfibrillary lesion formation. Neuropathology and Genetics of Dementia, 487 71-83.
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
Gotz, Jürgen, Tolnay, Markus, Barmettler, Robi, Chen, Feng, Probst, Alphonse and Nitsch, Roger M. (2001) Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. European Journal of Neuroscience, 13 11: 2131-2140. doi:10.1046/j.0953-816X.2001.01604.x
Tau filament formation in transgenic mice expressing P301L tau
Goetz, Juergen, Chen, Feng, Barmettler, Robi and Nitsch, Roger M. (2001) Tau filament formation in transgenic mice expressing P301L tau. Journal of Biological Chemistry, 276 1: 529-534. doi:10.1074/jbc.M006531200
Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types
Ferrari, A, Ehler, E, Nitsch, RM and Gotz, J (2000) Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types. Febs Letters, 486 2: 121-125. doi:10.1016/S0014-5793(00)02251-1
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
Probst, A, Gotz, J, Wiederhold, KH, Tolnay, M, Mistl, C, Jaton, AL, Hong, M, Ishihara, T, Lee, VMY, Trojanowski, JQ, Jakes, R, Crowther, RA, Spillantini, MG, Burki, K and Goedert, M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathologica, 99 5: 469-481.
Gotz, J, Probst, A, Mistl, C, Nitsch, RM and Ehler, E (2000) Distinct role of protein phosphatase 2A subunit C alpha in the regulation of E-cadherin and beta-catenin during development. Mechanisms of Development, 93 1-2: 83-93. doi:10.1016/S0925-4773(00)00267-7
In vivo analysis of wild-type and FTDP-17 tau transgenic mice
Gotz, J, Barmettler, R, Ferrari, A, Goedert, M, Probst, A and Nitsch, RM (2000) In vivo analysis of wild-type and FTDP-17 tau transgenic mice. Molecular Basis of Dementia, 920 126-133.
Goetz, Juergen and Kues, Wilfried (1999) The role of protein phosphatase 2A catalytic subunit Cα in embryogenesis: evidence from sequence analysis and localization studies. Biological Chemistry, 380 9: 1117-1120. doi:10.1515/BC.1999.139
Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα
Gotz J., Probst A., Ehler E., Hemmings B. and Kues W. (1998) Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα. National Academy of Sciences. Proceedings, 95 21: 12370-12375. doi:10.1073/pnas.95.21.12370
Shmerling, D, Hegyi, I, Fischer, M, Blattler, T, Brandner, S, Gotz, J, Rulicke, T, Flechsig, E, Cozzio, A, von Mering, C, Hangartner, C, Aguzzi, A and Weissmann, C (1998) Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell, 93 2: 203-214. doi:10.1016/S0092-8674(00)81572-X
Li Z.-W., Stark G., Gotz J., Rulicke T., Muller U. and Weissmann C. (1996) Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 93 12: 6158-6162. doi:10.1073/pnas.93.12.6158
Li, Z. W., Stark, G., Gotz, J., Rulicke, T., Gschwind, M., Huber, G., Muller, U. and Weissmann, C. (1996) Erratum: Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells (Proceedings of the National Academy of Sciences of the United States of America (June 11, 1996) 93:12 (6158-6162)). Proceedings of the National Academy of Sciences of the United States of America, 93 21: .
Molecular dissection of the paired helical filament
Goedert, M, Spillantini, MG, Jakes, R, Crowther, RA, Cohen, P, Vanmechelen, E, Probst, A, Gotz, J and Burki, K (1995) Molecular dissection of the paired helical filament. Neurobiology of Aging, 16 3: 325-334. doi:10.1016/0197-4580(95)00017-9
Gotz, J, Probst, A, Spillantini, MG, Schafer, T, Jakes, R, Burki, K and Goedert, M (1995) Somatodendritic Localization and Hyperphosphorylation of Tau-Protein in Transgenic Mice Expressing the Longest Human Brain Tau-Isoform. Embo Journal, 14 7: 1304-1313.
Tau-Protein in Alzheimers-Disease
Goedert, M, Jakes, R, Spillantini, MG, Crowther, RA, Cohen, P, Vanmechelen, E, Probst, A, Gotz, J and Burki, K (1995) Tau-Protein in Alzheimers-Disease. Biochemical Society Transactions, 23 1: 80-85.
Fgf5 as a Regulator of the Hair-Growth Cycle - Evidence From Targeted and Spontaneous Mutations
Hebert, JM, Rosenquist, T, Gotz, J and Martin, GR (1994) Fgf5 as a Regulator of the Hair-Growth Cycle - Evidence From Targeted and Spontaneous Mutations. Cell, 78 6: 1017-1025. doi:10.1016/0092-8674(94)90276-3
Gotz, J, Eibel, H and Kohler, G (1990) Nontolerance and Differential Susceptibility to Diabetes in Transgenic Mice Expressing Major Histocompatibility Class-Ii Genes On Pancreatic Beta-Cells. European Journal of Immunology, 20 8: 1677-1683. doi:10.1002/eji.1830200809
Cho, Kwy, Goetz, J, Wright, Cve, Fritz, A, Hardwicke, J and Derobertis, EM (1988) Differential Utilization of the Same Reading Frame in a Xenopus Homeobox Gene Encodes 2 Related Proteins Sharing the Same Dna-Binding Specificity. Embo Journal, 7 7: 2139-2149.
Homeotic-Like Genes in Xenopus-Laevis
Fritz, A, Gotz, J, Martin, G, Salo, E, Wright, J and Derobertis, E (1985) Homeotic-Like Genes in Xenopus-Laevis. Biological Chemistry Hoppe-Seyler, 366 9: 788-788.
Pathogenetic mechanisms in Down Syndrome
Einfeld, S., Goetz, J. and Holsinger, R. M. D. () Pathogenetic mechanisms in Down Syndrome. , 52 813-813. doi:10.1111/j.1365-2788.2008.01119_7.x
Lesne, Sylvain, Amar, Fatou, Sherman, Mathew, Rush, Travis, Larson, Megan, Chang, Liu, Gotz, Jurgen, Schneider, Julie, Bennett, David, Ashe, Karen and Buisson, Alain (2016). SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56. In: 14th International Athens/Springfield Symposium on Advances In Alzheimer Therapy, Athens, Greece, (S27-S27). Mar 09-12, 2016.
Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy
Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease
Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
The many facets of dementia - basic science and translational strategies
Gotz, Jurgen (2016). The many facets of dementia - basic science and translational strategies. In: Unknown, Unknown, (11-11). Unknown.
Effects of scanning focused ultrasound in an Alzheimer's mouse model
Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (274-275). 23 - 27 August 2015.
Neurotrophin regulation of Alzheimer's disease pathology
Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (208-208). 23-27 August 2015. doi:10.1111/jnc.13188
Novel strategies to target tau and Ab toxicity
Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186
Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (277-278). 23 - 27 August 2015.
Striatal deficits underlie conflicted patterns of action selection in ageing
Matamales, M., Skrbis, Z., Balleine, B., Goetz, J. and Bertran-Gonzalez, J. (2015). Striatal deficits underlie conflicted patterns of action selection in ageing. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (144-144). 23-27 August 2015. doi:10.1111/jnc.13188
Novel functions of the protein tau in disease
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Convergence of amyloid-β and tau pathologies on mitochondria in vivo
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Axonal transport in tau transgenic mouse models
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Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse
Schroeder, H., Goetz, J., Pilz, K., Kuhlage, S., de Vos, R. A. I., Bauer, T., Selzer, A. and Koehler, C. (2009). Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse. In: New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009. 9th International Conference on Alzheimers and Parkinson's Diseases (AD/PD), Prague Czech Republic, (233-237). Mar 11-15, 2009.
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Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles
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Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro
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Amyloid-induced neurofibrillary tangle formation
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Tau protein in Alzheimer's disease
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Regulation of mRNA translation by the microtubule-associated protein Tau
(2019–2021) ARC Discovery Projects
Unravelling how exosomes induce and propagate tau pathology
(2019–2021) NHMRC Project Grant
MM Electrical Merchandising Mid-Career Fellowship (Alzheimer's Disease)
(2018–2024) Metal Manufacturers Limited
Exploring Scanning Ultrasound (SUS), a novel method to treat and prevent neurodegenerative disease
(2018–2021) NHMRC Project Grant
Role of the microglial adaptor molecule TYROBP in Alzheimer's disease pathology
(2018–2021) NHMRC Project Grant
Scanning ultrasound to treat dementia
(2018–2020) Research Donation Generic
Translational Ultrasound for Alzheimer's disease treatment
(2018–2020) Research Donation Generic
(2018) UQ Major Equipment and Infrastructure
Tau and ITS master regulator Fyn in Neurons
(2017–2019) NHMRC Project Grant
Treatment of transgenic mouse models of frontotemporal dementia with novel tau-specific antibodies
(2016–2021) The Yulgilbar Foundation
(2016–2019) The Yulgilbar Foundation
A novel click chemistry approach to identify learning and memory molecules
(2016–2018) ARC Discovery Projects
Light-sheet microscope for high-speed 3D imaging of live organisms and fixed tissue
(2016) NHMRC Equipment Grant
Translational Ultrasound Project
(2015–2020) Research Donation Generic
(2015) UQ Major Equipment and Infrastructure
Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
(2015) NHMRC Equipment Grant
(2015) UQ Major Equipment and Infrastructure
(2014–2019) NHMRC Other Strategic Funding Initiatives
AADRF Postdoctoral Fellowship: Targeting pathogenic tau with phosphorylated-tau specific intrabodies
(2014–2016) Alzheimer's Australia Dementia Research Foundation
Generation of phosphorylated tau-specific intrabodies for the treatment of tauopathies
(2014–2015) Brain Foundation
Touchscreen-automated cognitive testing for mice
(2014) NHMRC Equipment Grant
Operation of the Clem Jones Centre for Ageing Dementia Research (CJCADR)
(2013–2019) Queensland Government Department of Science, Information Technology, Innovation and the Arts
Peter Hilton Research Fellowship in Dementia
(2013–2018) Research Donation Generic
(2013–2017) University of Sydney
Nuclear functions of the microtubule-associated protein tau
(2013–2015) ARC Discovery Projects
A facility for ex-vivo molecular imaging
(2013–2014) ARC Linkage Infrastructure, Equipment and Facilities
Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
(2013) UQ Major Equipment and Infrastructure
Centre for Ageing Dementia Research at The Queensland Brain Institute
(2012–2022) Research Donation Generic
Selective vulnerability in Alzheimer's Disease and related disorders: Mechanism of tau pathology
(2012–2015) NHMRC Project Grant
Analysis of how tau spreads and forms aggregated lesions in Alzheimer¿s disease models
Doctor Philosophy — Principal Advisor
The role of tyrosine kinases Pyk2, Fyn and the tyrosine phosphatase STEP in neurodegeneration and neurophysiology
Doctor Philosophy — Principal Advisor
The role of de novo protein synthesis in neurodegenerative disease
Doctor Philosophy — Principal Advisor
Other advisors:
Understanding ultrasound mediated blood brain barrier opening as a potential non invasive therapeutic approach in Alzheimer disease
Doctor Philosophy — Principal Advisor
Other advisors:
Synaptic Apoptosis in Alzheimer's Disease
Doctor Philosophy — Principal Advisor
Other advisors:
Dynamic Reorganization of Presynaptic Proteins During Neurotransmission and Neuronal Degeneration
Doctor Philosophy — Associate Advisor
Other advisors:
Dynamics of dendritic spines in early stage in vitro and in vivo models of Alzheimers disease
Doctor Philosophy — Associate Advisor
Other advisors:
Investigating intrabody-mediated delivery of anti-tau antibodies
Doctor Philosophy — Associate Advisor
Other advisors:
The Role of Microglia in Traumatic Brain Injury
Doctor Philosophy — Associate Advisor
Other advisors:
New pet imaging agents for the early detection of alzheimers disease
Doctor Philosophy — Associate Advisor
Other advisors:
The Role of Tau in Mitochondrial Dynamics and Quality Control
(2018) Doctor Philosophy — Principal Advisor
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer's disease.
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
The molecular mechanism of the Tau-Fyn interaction and dendritic targeting in neurons
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Metabolic study of Alzheimer's disease using mutant C. elegans
(2017) Doctor Philosophy — Associate Advisor
Other advisors:
Neurotrophin Regulation of Alzheimer's Disease Pathology
(2016) Doctor Philosophy — Associate Advisor
Other advisors: