The University of Queensland

Stem cell therapy in Alzheimer's disease models: neurogenesis versus trophic support

Goetz, Juergen and Buettner, Sven (2012). Stem cell therapy in Alzheimer's disease models: neurogenesis versus trophic support. In Kuldip S. Sidhu (Ed.), Frontiers in pluripotent stem cells research and therapeutic potentials bench-to-bedside (pp. 220-226) London, United Kingdom: Bentham Science. doi:10.2174/97816080528991120101

Local oxidative damage in the soma and dendrites quarantines neuronal mitochondria at the site of insult

Grimm, Amandine, Cummins, Nadia and Götz, Jürgen (2018) Local oxidative damage in the soma and dendrites quarantines neuronal mitochondria at the site of insult. iScience, 6 114-127. doi:10.1016/j.isci.2018.07.015

Pyk2 is a novel tau tyrosine kinase that is regulated by the tyrosine kinase fyn

Li, Chuanzhou and Götz, Jürgen (2018) Pyk2 is a novel tau tyrosine kinase that is regulated by the tyrosine kinase fyn. Journal of Alzheimer's Disease, 64 1: 205-221. doi:10.3233/JAD-180054

Modeling ultrasound propagation through material of increasing geometrical complexity

Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018) Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90 52-62. doi:10.1016/j.ultras.2018.05.014

Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

Nisbet, Rebecca M. and Götz, Jürgen (2018) Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies. Journal of Alzheimer's Disease, . doi:10.3233/JAD-179907

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

Polanco, Juan Carlos, Li, Chuanzhou, Durisic, Nela, Sullivan, Robert and Götz, Jürgen (2018) Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons. Acta Neuropathologica Communications, 6 1: 1-14. doi:10.1186/s40478-018-0514-4

Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice

Leinenga, Gerhard and Gotz, Jurgen (2018) Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 1-10. doi:10.3389/fnins.2018.00055

A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles

Brici, David, Götz, Jürgen and Nisbet, Rebecca M. (2018) A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. Journal of Alzheimer's Disease : JAD, 61 3: 899-905. doi:10.3233/JAD-170610

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018) Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 9: 2583-2602. doi:10.7150/thno.22852

Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies

Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017) Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 1: 22-40. doi:10.1038/nrneurol.2017.162

Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies

Forrest, Shelley L., Kril, Jillian J., Stevens, Claire H., Kwok, John B., Hallupp, Marianne, Kim, Woojin S., Huang, Yue, McGinley, Ciara V., Werka, Hellen, Kiernan, Matthew C., Götz, Jürgen, Spillantini, Maria Grazia, Hodges, John R., Ittner, Lars M. and Halliday, Glenda M. (2017) Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies. Brain : A Journal of Neurology, 141 2: 521-534. doi:10.1093/brain/awx328

Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

Cummins, Nadia and Götz, Jürgen (2017) Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?. Cellular and Molecular Life Sciences, . doi:10.1007/s00018-017-2692-9

A corticostriatal deficit promotes temporal distortion of automatic action in ageing

Matamales, Miriam, Skrbis, Zala, Bailey, Matthew R, Balsam, Peter D, Balleine, Bernard W, Götz, Jürgen and Bertran-Gonzalez, Jesus (2017) A corticostriatal deficit promotes temporal distortion of automatic action in ageing. eLife, 6 . doi:10.7554/eLife.29908

Tau-based therapies in neurodegeneration: opportunities and challenges

Li, Chuanzhou and Götz, Jürgen (2017) Tau-based therapies in neurodegeneration: opportunities and challenges. Nature Reviews Drug Discovery, 16 12: 863-883. doi:10.1038/nrd.2017.155

Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.

Li, Chuanzhou and Götz, Jürgen (2017) Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.. EMBO Journal, 36 17: 3120-3138. doi:10.15252/embj.201797724

Ultrasound as a treatment modality for neurological diseases

Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017) Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 11: 470-471. doi:10.5694/mja16.01013

The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Amar, Fatou, Sherman, Mathew A., Rush, Travis, Larson, Megan, Boyle, Gabriel, Chang, Liu, Gotz, Jurgen, Buisson, Alain and Lesne, Sylvain E. (2017) The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Science Signaling, 10 478: . doi:10.1126/scisignal.aal2021

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017) Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 5: 1220-1230. doi:10.1093/brain/awx052

Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment

Hatch, Robert John, Wei, Yan, Xia, Di and Gotz, Jürgen (2017) Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta Neuropathologica, 133 5: 717-730. doi:10.1007/s00401-017-1674-1

Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology

Ahmed, Rebekah M., Irish, Muireann, van Eersel, Janet, Ittner, Arne, Ke, Yazi D., Volkerling, Alexander, van der Hoven, Julia, Tanaka, Kimi, Karl, Tim, Kassiou, Michael, Kril, Jillian J., Piguet, Olivier, Goetz, Juergen, Kiernan, Matthew C., Halliday, Glenda M., Hodges, John R. and Ittner, Lars M. (2017) Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology. Neuroscience and Biobehavioral Reviews, 74 A: 126-138. doi:10.1016/j.neubiorev.2017.01.004

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model

Bodea, Liviu-Gabriel, Evans, Harrison Tudor, Van der Jeugd, Ann, Ittner, Lars M., Delerue, Fabien, Kril, Jillian, Halliday, Glenda, Hodges, John, Kiernan, Mathew C. and Goetz, Juergen (2017) Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell, 16 2: 377-386. doi:10.1111/acel.12565

Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice

Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016) Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 10: e0164278. doi:10.1371/journal.pone.0164278

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease

Jiao, S. -S., Shen, L. -L., Zhu, C., Bu, X. -L., Liu, Y. -H., Liu, C. -H., Yao, X. -Q., Zhang, L. -L., Zhou, H. -D., Walker, D. G., Tan, J., Goetz, J., Zhou, X. -F. and Wang, Y. -J. (2016) Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Translational Psychiatry, 6 10: . doi:10.1038/tp.2016.186

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016) Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 6: 705-718. doi:10.1083/jcb.201512016

Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'

Brandt, Roland and Goetz, Juergen (2016) Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'. Brain Research Bulletin, 126 3: 213-216. doi:10.1016/j.brainresbull.2016.08.003

Motor cortical function determines prognosis in sporadic ALS

Shibuya, Kazumoto, Park, Susanna B., Geevasinga, Nimeshan, Menon, Parvathi, Howells, James, Simon, Neil G., Huynh, William, Noto, Yu-ichi, Gotz, Jurgen, Kril, Jillian J., Ittner, Lars M., Hodges, John, Halliday, Glenda, Vucic, Steve and Kiernan, Matthew C. (2016) Motor cortical function determines prognosis in sporadic ALS. Neurology, 87 5: 513-520. doi:10.1212/WNL.0000000000002912

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

Bodea, Liviu-Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier and Götz, Juergen (2016) Tau physiology and pathomechanisms in frontotemporal lobar degeneration. Journal of Neurochemistry, 138 S1: 71-94. doi:10.1111/jnc.13600

Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

Xia, Di, Gutmann, Julia M. and Gotz, Jurgen (2016) Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific Reports, 6 . doi:10.1038/srep29074

Quantitative imaging of cholinergic interneurons reveals a distinctive spatial organization and a functional gradient across the mouse striatum

Matamales, Miriam, Gotz, Jurgen and Bertran-Gonzalez, Jesus (2016) Quantitative imaging of cholinergic interneurons reveals a distinctive spatial organization and a functional gradient across the mouse striatum. PLoS One, 11 6: 1-13. doi:10.1371/journal.pone.0157682

Extracellular vesicles isolated from the brains of rTg4510 mice seed tau protein aggregation in a threshold-dependent manner

Polanco, Juan Carlos, Scicluna, Benjamin James, Hill, Andrew Francis and Gotz, Jurgen (2016) Extracellular vesicles isolated from the brains of rTg4510 mice seed tau protein aggregation in a threshold-dependent manner. Journal of Biological Chemistry, 291 24: 12445-12466. doi:10.1074/jbc.M115.709485

Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection

Matamales, Miriam, Skrbis, Zala, Hatch, Robert J., Balleine, Bernard W., Gotz, Jurgen and Bertran-Gonzalez, Jesus (2016) Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection. Neuron, 90 2: 362-373. doi:10.1016/j.neuron.2016.03.006

Co-immunoprecipitation with Tau isoform-specific antibodies reveals distinct protein interactions and highlights a putative role for 2N Tau in disease

Liu, Chang, Song, Xiaomin, Nisbet, Rebecca and Goetz, Juergen (2016) Co-immunoprecipitation with Tau isoform-specific antibodies reveals distinct protein interactions and highlights a putative role for 2N Tau in disease. Journal of Biological Chemistry, 291 15: 8173-8188. doi:10.1074/jbc.M115.641902

A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

Baker, Sian and Götz, Jürgen (2016) A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathologica Communications, 4 32.1-32.13. doi:10.1186/s40478-016-0300-0

Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia

Van der Jeugd, Ann, Vermaercke, Ben, Halliday, Glenda M., Staufenbiel, Matthias and Gotz, Jürgen (2016) Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiology of Learning and Memory, 130 34-43. doi:10.1016/j.nlm.2016.01.007

The frontotemporal dementia-motor neuron disease continuum

Burrell, James R., Halliday, Glenda M., Kril, Jillian J., Ittner, Lars M., Gotz, Jurgen, Kiernan, Matthew C. and Hodges, John R. (2016) The frontotemporal dementia-motor neuron disease continuum. The Lancet, 388 10047: 919-931. doi:10.1016/S0140-6736(16)00737-6

Ultrasound treatment of neurological diseases — current and emerging applications

Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016) Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 3: 161-174. doi:10.1038/nrneurol.2016.13

Extracellular vesicles containing P301L mutant tau accelerate pathological tau phosphorylation and oligomer formation but do not seed mature neurofibrillary tangles in ALZ17 mice

Baker, Sian, Polanco, Juan Carlos and Gotz, Juergen (2016) Extracellular vesicles containing P301L mutant tau accelerate pathological tau phosphorylation and oligomer formation but do not seed mature neurofibrillary tangles in ALZ17 mice. Journal of Alzheimer's Disease, 54 3: 1207-1217. doi:10.3233/JAD-160371

Glutamate receptors in alzheimer's disease: mechanisms and therapies

Anggono, Victor, Tsai, Li-Huei and Goetz, Juergen (2016) Glutamate receptors in alzheimer's disease: mechanisms and therapies. Neural Plasticity, 2016 . doi:10.1155/2016/8256196

No full admission for tau to the exclusive prion club yet

Polanco, Juan Carlos and Götz, Jürgen (2015) No full admission for tau to the exclusive prion club yet. EMBO Journal, 34 24: 2990-2992. doi:10.15252/embj.201593311

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

Grimm, Amandine, Biliouris, Emily E., Lang, Undine E., Gotz, Jurgen, Mensah-Nyagan, Ayikoe Guy and Eckert, Anne (2015) Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein. Cellular and Molecular Life Sciences, 73 1: 201-215. doi:10.1007/s00018-015-1988-x

FTD and ALS—translating mouse studies into clinical trials

Ittner, Lars M., Halliday, Glenda M., Kril, Jillian J., Götz, Jürgen, Hodges, John R. and Kiernan, Matthew C. (2015) FTD and ALS—translating mouse studies into clinical trials. Nature Reviews Neurology, 11 6: 360-366. doi:10.1038/nrneurol.2015.65

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

Xia, Di, Li, Chuanzhou and Gotz, Jurgen (2015) Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1852 5: 913-924. doi:10.1016/j.bbadis.2014.12.017

Dementia and neurodegeneration - role of mitochondria and oxidative stress in Alzheimer's disease

Cummins, Nadia and Götz, Jurgen (2015) Dementia and neurodegeneration - role of mitochondria and oxidative stress in Alzheimer's disease. Australian Biochemist, 46 1: 4-7.

Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model

Leinenga, Gerhard and Götz, Jürgen (2015) Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 278: 278ra33.1-278ra33.12. doi:10.1126/scitranslmed.aaa2512

Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress

Chew, Yee Lian, Gotz, Jurgen and Nicholas, Hannah R. (2015) Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress. Aging Cell, 14 1: 148-151. doi:10.1111/acel.12285

What we can learn from animal models about cerebral multi-morbidity

Baker, Sian and Gotz, Jurgen (2015) What we can learn from animal models about cerebral multi-morbidity. Alzheimer's Research and Therapy, 7 11: . doi:10.1186/s13195-015-0097-2

Connecting the dots between tau dysfunction and neurodegeneration

Frost, Bess, Gotz, Jurgen and Feany, Mel B. (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology, 25 1: 46-53. doi:10.1016/j.tcb.2014.07.005

Tau aggregation and its interplay with amyloid-β

Nisbet, Rebecca M., Polanco, Juan-Carlos, Ittner, Lars M. and Gotz, Jurgen (2014) Tau aggregation and its interplay with amyloid-β. Acta Neuropathologica, 129 2: 207-220. doi:10.1007/s00401-014-1371-2

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis

Kohler, Christoph, Dinekov, Maja and Gotz, Jürgen (2014) Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis. Neurobiology of Disease, 71 169-179. doi:10.1016/j.nbd.2014.07.006

Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome

Liang, Vanessa, Ullrich, Milena, Lam, Hong, Chew, Yee Lian, Banister, Samuel, Song, Xiaomin, Zaw, Thiri, Kassiou, Michael, Gotz, Jürgen and Nicholas, Hannah R. (2014) Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71 17: 3339-3361. doi:10.1007/s00018-014-1558-7

Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans

Ullrich, Milena, Liang, Vanessa, Chew, Yee Lian, Banister, Samuel, Song, Xiaomin, Zaw, Thiri, Lam, Hong, Berber, Slavica, Kassiou, Michael, Nicholas, Hannah R. and Goetz, Juergen (2014) Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9 9: 2237-2255. doi:10.1038/nprot.2014.150

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice

Ittner, Arne, Bertz, Josefine, Suh, Lisa S., Stevens, Claire H., Gotz, Jurgen and Ittner, Lars M. (2014) Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. Journal of Neurochemistry, 132 1: 1-11. doi:10.1111/jnc.12821

Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous

Chew, Yee Lian, Fan, Xiaochen, Gotz, Jurgen and Nicholas, Hannah R. (2014) Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific Reports, 4 . doi:10.1038/srep05185

Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn

Xia, Di and Gotz, Jurgen (2014) Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Frontiers in Molecular Neuroscience, 7 MAY: 1-11. doi:10.3389/fnmol.2014.00040

The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells

Chen, JinYan, Sun, MengRu, Wang, XingHua, Lu, Jing, Wei, Yan, Tan, Yan, Liu, Ying, Gotz J., He, RongQiao and Hua, Qian (2014) The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Science China Life Sciences, 57 4: 412-421. doi:10.1007/s11427-014-4643-0

Visualizing the microtubule-associated protein tau in the nucleus

Lu, Jing, Li, Ting, He, RongQiao, Bartlett, Perry F. and Gotz, Jürgen (2014) Visualizing the microtubule-associated protein tau in the nucleus. Science China Life Sciences, 57 4: 422-431. doi:10.1007/s11427-014-4635-0

Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus

Liu, Chang and Goetz, Juergen (2013) Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PloS One, 8 12: . doi:10.1371/journal.pone.0084849

March separate, strike together: role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

Eckert, Anne, Nisbet, Rebecca, Grimm, Amandine and Götz, Jürgen (2013) March separate, strike together: role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1842 8: 1258-1266. doi:10.1016/j.bbadis.2013.08.013

Aging in the nervous system of Caenorhabditis elegans

Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) Aging in the nervous system of Caenorhabditis elegans. Communicative and Integrative Biology, 6 5: e25288.1-e25288.6. doi:10.4161/cib.25288

Lessons from two prevalent amyloidoses-what amylin and A beta have in common

Goetz, Juergen, Lim, Yun-An and Eckert, Anne (2013) Lessons from two prevalent amyloidoses-what amylin and A beta have in common. Frontiers in Aging Neuroscience, 5 AUG: 38.1-38.9. doi:10.3389/fnagi.2013.00038

What renders TAU toxic

Goetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013) What renders TAU toxic. Frontiers in Neurology, 4 72.1-72.10. doi:10.3389/fneur.2013.00072

Why size matters - balancing mitochondrial dynamics in Alzheimer's disease

DuBoff, Brian, Feany, Mel and Goetz, Juergen (2013) Why size matters - balancing mitochondrial dynamics in Alzheimer's disease. Trends in Neurosciences, 36 6: 325-335. doi:10.1016/j.tins.2013.03.002

Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice

Koehler, Christoph, Dinekov, Maja and Goetz, Juergen (2013) Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiology of Aging, 34 5: 1369-1379. doi:10.1016/j.neurobiolaging.2012.11.010

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

Nilsen, Linn Hege, Rae, Caroline, Ittner, Lars M., Goetz, Juergen and Sonnewald, Ursula (2013) Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism, 33 5: 684-691. doi:10.1038/jcbfm.2012.212

PTL-1 regulates neuronal integrity and lifespan in C-elegans

Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) PTL-1 regulates neuronal integrity and lifespan in C-elegans. Journal of Cell Science, 126 9: 2079-2091. doi:10.1242/jcs.jcs124404

Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice

Morcinek, Kerstin, Köhler, Christoph, Goetz, Juergen and Schröder, Hannsjorg (2013) Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Research, 1497 73-84. doi:10.1016/j.brainres.2012.12.016

How it all started: Tau and protein phosphatase 2A

Liu, Chang and Goetz, Juergen (2013) How it all started: Tau and protein phosphatase 2A. Journal of Alzheimer's Disease, 37 3: 483-494. doi:10.3233/jad-130503

Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition

Delerue, Fabien, Sjollema, Geoff, Whittle, Belinda, Krueger, Sarah, Andrews, Dan and Goetz, Juergen (2013) Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition. Journal of Alzheimers Disease, 36 2: 349-363. doi:10.3233/JAD-130089

Decoding the non-coding RNAs in Alzheimer's disease

Schonrock, Nicole and Goetz, Juergen (2012) Decoding the non-coding RNAs in Alzheimer's disease. Cellular and Molecular Life Sciences, 69 21: 3543-3559. doi:10.1007/s00018-012-1125-z

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

DuBoff, Brian, Goetz, Juergen and Feany, Mel B. (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron, 75 4: 618-632. doi:10.1016/j.neuron.2012.06.026

Alzheimer's disease models and functional genomics-how many needles are there in the haystack?

Goetz, Juergen, Matamales, Miriam, Goetz, Naeman N., Ittner, Lars M. and Eckert, Anne (2012) Alzheimer's disease models and functional genomics-how many needles are there in the haystack?. Frontiers in Physiology, 3 320: 320.1-320.14. doi:10.3389/fphys.2012.00320

Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship

Grimm, Amandine, Lim, Yun-An, Mensah-Nyagan, Ayikoe Guy, Goetz, Jurgen and Eckert, Anne (2012) Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship. Molecular Neurobiology, 46 1: 151-160. doi:10.1007/s12035-012-8281-x

MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease

Schonrock, Nicole, Matamales, Miriam, Ittner, Lars M. and Gotz, Juergen (2012) MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease. Experimental Neurology, 235 2: 447-454. doi:10.1016/j.expneurol.2011.11.013

Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease

Ke, Yazi, Dramiga, Joe, Schütz, Ulrich, Kril, Jillian J., Ittner, Lars M., Schröder, Hannsjörg and Götz, Jürgen (2012) Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PloS One, 7 4: 1-8. doi:10.1371/journal.pone.0035678

Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio

Schmitt, Karen, Grimm, Amandine, Kazmierczak, Anna, Strosznajder, Joanna B., Gotz, Jurgen and Eckert, Anne (2012) Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio. Antioxidants and Redox Signaling, 16 12: 1456-1466. doi:10.1089/ars.2011.4400

A neuroprotective role for the DNA damage checkpoint in tauopathy

Khurana, Vikram, Merlo, Paola, DuBoff, Brian, Fulga, Tudor A., Sharp, Katherine A., Campbell, Shelagh D., Goetz, Juergen and Feany, Mel B. (2012) A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell, 11 2: 360-362. doi:10.1111/j.1474-9726.2011.00778.x

Tau-targeted treatment strategies in Alzheimer's disease

Gotz, Jurgen, Ittner, Arne and Ittner, Lars M. (2012) Tau-targeted treatment strategies in Alzheimer's disease. British Journal of Pharmacology, 165 5: 1246-1259. doi:10.1111/j.1476-5381.2011.01713.x

Role of hippocalcin in mediating Aβ toxicity

Lim, Yun-An, Giese, Maria, Shepherd, Claire, Halliday, Glenda, Kobayashi, Masaaki, Takamatsu, Ken, Staufenbiel, Matthias, Eckert, Anne and Gotz, Jürgen (2012) Role of hippocalcin in mediating Aβ toxicity. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1822 8: 1247-1257. doi:10.1016/j.bbadis.2012.04.007

Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.

Schonrock, Nicole, Humphreys, David T., Preiss, Thomas and Gotz, Jürgen (2012) Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.. Journal of Molecular Neuroscience, 46 2: 324-335. doi:10.1007/s12031-011-9587-2

Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol

Lim, Yun-An, Grimm, Amandine, Giese, Maria, Mensah-Nyagan, Ayikoe Guy, Villafranca, J. Ernest, Ittner, Lars M., Eckert, Anne and Gotz, Jurgen (2011) Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS ONE, 6 12: e28887.1-e28887.12. doi:10.1371/journal.pone.0028887

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

Bi, Mian, Ittner, Arne, Ke, Yazi D., Gotz, Jurgen and Ittner, Lars M. (2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS ONE, 6 12: e26860.1-e26860.7. doi:10.1371/journal.pone.0026860

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons

van Eersel, Janet, Ke, Yazi D., Gladbach, Amadeus, Bi, Mian, Gotz, Jurgen, Kril, Jillian J. and Ittner, Lars M. (2011) Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS ONE, 6 7: e22850.1-e22850.13. doi:10.1371/journal.pone.0022850

Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity

Eckert, Anne, Schmitt, Karen and Gotz, Jurgen (2011) Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity. Alzheimer's Research and Therapy, 3 3: 15.1-15.11. doi:10.1186/alzrt74

Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

Louis, Justin V., Martens, Ellen, Borghgraef, Peter, Lambrecht, Caroline, Sents, Ward, Longin, Sari, Zwaenepoel, Karen, Pijnenborg, Robert, Landrieu, Isabelle, Lippens, Guy, Ledermann, Birgit, Gotz, Jürgen, Van Leuven, Fred, Goris, Jozef and Janssens, Veerle (2011) Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β. Proceedings of the National Academy of Sciences of the United States of America, 108 17: 6957-6962. doi:10.1073/pnas.1018777108

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation

Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. and Brandt, R. (2011) Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging, 32 6: 991-1006. doi:10.1016/j.neurobiolaging.2009.06.007

Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease

Ittner, Lars M. and Gotz, Jürgen (2011) Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease. Nature Reviews Neuroscience, 12 2: 67-72. doi:10.1038/nrn2967

Brief update on different roles of tau in neurodegeneration

Ittner, Arne, Ke, Yazi D., van Eersel, Janet, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2011) Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63 7: 495-502. doi:10.1002/iub.467

ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice

Liu, Xin, Dobbie, Michael, Tunningley, Rob, Whittle, Belinda, Zhang, Yafei, Ittner, Lars M. and Gotz, Jurgen (2011) ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. Journal of Biomedicine and Biotechnology, 2011 130947.1-130947.11. doi:10.1155/2011/130947

Invertebrate and Vertebrate Models of Tauopathies

Goetz, Juergen, Ittner, Lars M., Goetz, Naeman N., Lam, Hong and Nicholas, Hannah R. (2011) Invertebrate and Vertebrate Models of Tauopathies. Animal Models for Neurodegenerative Disease, 6: 69-85. doi:10.1039/9781849732758

Modes of Aβ toxicity in Alzheimer's disease

Gotz, Jurgen, Eckert, Anne, Matamales, Miriam, Ittner, Lars M. and Liu, Xin (2011) Modes of Aβ toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68 20: 3359-3375. doi:10.1007/s00018-011-0750-2

Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice

Attems, Johannes, Ittner, Arne, Jellinger, Kurt, Nitsch, Roger M., Maj, Magdalena, Wagner, Ludwig, Gotz, Jurgen and Heikenwalder, Mathias (2011) Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of Neural Transmission, 118 5: 737-745. doi:10.1007/s00702-011-0626-5

Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy

Kohler, C., Bista, P., Gotz, J. and Schroder, H. (2010) Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Research, 1347 111-124. doi:10.1016/j.brainres.2010.05.076

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

van Eersel, Janet, Ke, Yazi D., Liu, Xin, Delerue, Fabien, Kril, Jillian J., Gotz, Jürgen and Ittner, Lars M. (2010) Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America, 107 31: 13888-13893. doi:10.1073/pnas.1009038107

Convergence of amyloid-β and tau pathologies on mitochondria in vivo

Eckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Gotz, Jürgen (2010) Convergence of amyloid-β and tau pathologies on mitochondria in vivo. Molecular Neurobiology, 41 2-3: 107-114. doi:10.1007/s12035-010-8109-5

Neuronal microrna deregulation in response to Alzheimer's disease amyloid-β

Schonrock, Nicole, Ke, Yazi D., Humphreys, David, Staufenbiel, Matthias, Ittner, Lars M., Preiss, Thomas and Gotz, Jurgen (2010) Neuronal microrna deregulation in response to Alzheimer's disease amyloid-β. PLoS ONE, 5 6: e11070.1-e11070.11. doi:10.1371/journal.pone.0011070

Dissecting Toxicity of Tau and β-Amyloid

Gotz, Jurgen, Lim, Yun-An, Ke, Yazi D., Eckert, Anne and Ittner, Lars M. (2010) Dissecting Toxicity of Tau and β-Amyloid. Neurodegenerative Diseases, 7 1-3: 10-12. doi:10.1159/000283475

Animal models reveal role for tau phosphorylation in human disease

Gotz, Jurgen, Gladbach, Amadeus, Pennanen, Luis, van Eersel, Janet, Schild, Andreas, David, Della and Ittner, Lars M. (2010) Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 10: 860-871. doi:10.1016/j.bbadis.2009.09.008

Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction

Lim, Yun-An, Rhein, Virginie, Baysang, Ginette, Meier, Fides, Poljak, Anne, Raftery, Mark J., Guilhaus, Michael, Ittner, Lars M., Eckert, Anne and Gotz, Jürgen (2010) Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics, 10 8: 1621-1633. doi:10.1002/pmic.200900651

Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models

Ittner, Lars M., Ke, Yazi D., Delerue, Fabien, Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Wolfing, Heidrun, Chieng, Billy C., Christie, MacDonald J., Napier, Ian A., Eckert, Anne, Staufenbiel, Matthias, Hardeman, Edna and Gotz, Jurgen (2010) Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell, 142 3: 387-397. doi:10.1016/j.cell.2010.06.036

Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins

Krupka, Niklas, Strappe, Padraig, Gotz, Jürgen and Ittner, Lars M. (2010) Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid, 63 3: 155-160. doi:10.1016/j.plasmid.2010.01.002

Parkinson's disease: insights from non-traditional model organisms

Pienaar, Ilse S., Gotz, Jürgen and Feany, Mel B. (2010) Parkinson's disease: insights from non-traditional model organisms. Progress in Neurobiology, 92 4: 558-571. doi:10.1016/j.pneurobio.2010.09.001

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Rhein, Virginie, Song, Xiaomin, Wiesner, Andreas, Ittner, Lars M., Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Drose, Stefan, Brandt, Ulrich, Savaskan, Egemen, Czech, Christian, Gotz, Jurgen and Eckert, Anne (2009) Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America, 106 47: 20057-20062. doi:10.1073/pnas.0905529106

Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease

Ke, Yazi D., Delerue, Fabien, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2009) Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS ONE, 4 11: e7917.1-e7917.7. doi:10.1371/journal.pone.0007917

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

Ittner, Lars M., Ke, Yazi D. and Gotz, Jurgen (2009) Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. Journal of Biological Chemistry, 284 31: 20909-20916. doi:10.1074/jbc.M109.014472

Substrate-specific reduction of PP2A activity exaggerates tau pathology

Deters, Natasha, Ittner, Lars M. and Gotz, Jurgen (2009) Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and Biophysical Research Communications, 379 2: 400-405. doi:10.1016/j.bbrc.2008.12.140

Alzheimer's disease selective vulnerability and modeling in transgenic Mice

Gotz, Jurgen, Schonrock, Nicole, Vissel, Bryce and Ittner, Lars M. (2009) Alzheimer's disease selective vulnerability and modeling in transgenic Mice. Journal of Alzheimer's Disease, 18 2: 243-251. doi:10.3233/JAD-2009-1143

Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains

van Eersel, Janet, Bi, Mian, Ke, Yazi D., Hodges, John R., Xuereb, John H., Gregory, Gillian C., Halliday, Glenda M., Gotz, Jurgen, Kril, Jillian J. and Ittner, Lars M. (2009) Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission, 116 10: 1243-1251. doi:10.1007/s00702-009-0293-y

Primary support cultures of hippocampal and substantia nigra neurons

Fath, Thomas, Ke, Yazi D., Gunning, Peter, Gotz, Jürgen and Ittner, Lars M. (2009) Primary support cultures of hippocampal and substantia nigra neurons. Nature Protocols, 4 1: 78-85. doi:10.1038/nprot.2008.199

An update on the toxicity of A-beta in Alzheimer's disease

Götz, Jurgen, Ittner, Lars M, Schonrock, Nicole and Cappai, Roberto (2008) An update on the toxicity of A-beta in Alzheimer's disease. Neuropsychiatric Disease and Treatment, 4 6: 1033-1042. doi:10.2147/NDT.S3016

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

Ittner, Lars M., Fath, Thomas, Ke, Yazi D., Bi, Mian, van Eersel, Janet, Li, Kong M., Gunning, Peter and Gotz, Jurgen (2008) Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America, 105 41: 15997-16002. doi:10.1073/pnas.0808084105

Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

Lim, Yun-An, Ittner, Lars M., Lim, Yun Li and Gotz, Jürgen (2008) Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures. FEBS Letters, 582 15: 2188-2194. doi:10.1016/j.febslet.2008.05.006

Antiviral CD8 T cells recognize Borna disease virus antigen transgenically expressed in either neurons or astrocytes

Baur, Karen, Rauer, Mathias, Richter, Kirsten, Pagenstecher, Axel, Gotz, Jurgen, Hausmann, Jurgen and Staeheli, Peter (2008) Antiviral CD8 T cells recognize Borna disease virus antigen transgenically expressed in either neurons or astrocytes. Journal of Virology, 82 6: 3099-3108. doi:10.1128/JVI.02479-07

Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response

Gotz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y.-A., Deters, N. and Ittner, L. M. (2008) Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegenerative Diseases, 5 3-4: 179-181. doi:10.1159/000113696

Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice

Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Rhein, Virginie, Muller-Spahn, Franz, Gotz, Jürgen and Muller, Walter E. (2008) Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegenerative Diseases, 5 3-4: 157-159. doi:10.1159/000113689

Animal models of Alzheimer's disease and frontotemporal dementia

Gotz, Jurgen and Ittner, Lars M. (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews Neuroscience, 9 7: 532-544. doi:10.1038/nrn2420

Divergent phosphorylation pattern of tau in P301L tau transgenic mice

Deters, Natasha, Ittner, Lars M. and Gotz, Jurgen (2008) Divergent phosphorylation pattern of tau in P301L tau transgenic mice. European Journal of Neuroscience, 28 1: 137-147. doi:10.1111/j.1460-9568.2008.06318.x

Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?

Goetz, Juergen, Ittner, Lars M., Faendrich, Marcus and Schonrock, Nicole (2008) Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?. Journal of Alzheimers Disease, 14 4: 423-429. doi:10.3233/JAD-2008-14410

Neuroproteomics as a promising tool in Parkinson's disease research

Pienaar, Ilse S., Daniels, William M. U. and Gotz, Jurgen (2008) Neuroproteomics as a promising tool in Parkinson's disease research. Journal of Neural Transmission, 115 10: 1413-1430. doi:10.1007/s00702-008-0070-3

Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice

Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Meinhardt, Jessica, Rhein, Virginie, Drose, Stefan, Brandt, Ulrich, Fandrich, Marcus, Muller, Walter E. and Gotz, Jürgen (2008) Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice. Journal of Molecular Medicine, 86 11: 1255-1267. doi:10.1007/s00109-008-0391-6

Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma

Ittner, Lars M., Schwerdtfeger, Kerstin, Kunz, Thomas H., Muff, Roman, Husmann, Knut, Grimm, Christian, Hafezi, Farhad, Langh, Karl S., Kurrer, Michael O., Gotz, Jurgen, Born, Walter and Fischer, Jan A. (2008) Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical Science, 114 1-2: 49-58. doi:10.1042/CS20070163

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

Habicht G., Haupt C., Friedrich R.P., Hortschansky P., Sachse C., Meinhardt J., Wieligmann K., Gellermann G.P., Brodhun M., Gotz J., Halbhuber K.-J., Rocken C., Horn U. and Fandrich M. (2007) Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils. Proceedings of the National Academy of Sciences of the United States of America, 104 49: 19232-19237. doi:10.1073/pnas.0703793104

Aβ treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry

Hoerndli, Frederic J., Pelech, Steven, Papassotiropoulos, Andreas and Gotz, Juergen (2007) Aβ treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. European Journal of Neuroscience, 26 1: 60-72. doi:10.1111/j.1460-9568.2007.05618.x

Possibilities for the prevention and treatment of cognitive impairment and dementia

Burke, David, Hickie, Ian, Breakspear, Michael and Gotz, Juergen (2007) Possibilities for the prevention and treatment of cognitive impairment and dementia. British Journal of Psychiatry, 190 5: 371-372. doi:10.1192/bjp.bp.106.033407

Pronuclear injection for the production of transgenic mice

Ittner, Lars M. and Gotz, Juergen (2007) Pronuclear injection for the production of transgenic mice. Nature Protocols, 2 5: 1206-1215. doi:10.1038/nprot.2007.145

β-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes

David, Della C., Ittner, Lars M., Gehrig, Peter, Nergenau, Denise, Shepherd, Claire, Halliday, Glenda and Gotz, Juergen (2006) β-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics, 6 24: 6566-6577. doi:10.1002/pmic.200600634

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation

Schild, Andreas, Schmidt, Karsten, Lim, Yun-An, Ke, Yazi, Ittner, Lars M., Hemmings, Brian A. and Gotz, Juergen (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International Journal of Developmental Neuroscience, 24 7: 437-443. doi:10.1016/j.ijdevneu.2006.08.005

Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?

Goetz, Juergen, Ittner, Lars M. and Schonrock, Nicole (2006) Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?. Medical Journal of Australia, 185 7: 381-384.

Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

Götz, Jürgen, Ittner, Lars M. and Kins, Stefan (2006) Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?. Journal of Neurochemistry, 98 4: 993-1006. doi:10.1111/j.1471-4159.2006.03955.x

Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice

Pennanen, L., Wolfer, D. P., Nitsch, R. M. and Gotz, J. (2006) Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, Brain and Behavior, 5 5: 369-379. doi:10.1111/j.1601-183X.2005.00165.x

Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

Schild, Andreas, Ittner, Lars M. and Gotz, Juergen (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and Biophysical Research Communications, 343 4: 1171-1178. doi:10.1016/j.bbrc.2006.03.066

Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice

Schild, Andreas, Isenmann, Stefan, Tanimoto, Naoyuki, Tonagel, Felix, Seeliger, Mathias W., Ittner, Lars M., Kretz, Alexandra, Ogris, Egon and Gotz, Juergen (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of Development, 123 5: 362-371. doi:10.1016/j.mod.2006.03.003

Active immunization trial in Aβ42-injected P301L tau transgenic mice

Kulic, Luka, Kurosinski, Pascal, Chen, Feng, Tracy, Jay, Mohajeri, M. Hasan, Li, Hong, Nitsch, Roger M. and Gotz, Juergen (2006) Active immunization trial in Aβ42-injected P301L tau transgenic mice. Neurobiology of Disease, 22 1: 50-56. doi:10.1016/j.nbd.2005.10.002

Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2

Tam, CW, Husmann, K, Clark, NC, Clark, JE, Lazar, Z, Ittner, LM, Gotz, J, Douglas, G, Grant, AD, Sugden, D, Poston, L, Poston, R, McFadzean, I, Marber, MS, Fischer, JA, Born, W and Brain, SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2. Circulation Research, 98 2: 262-270. doi:10.1161/01.RES.0000200737.638.65.58

P70 S6 kinase mediates tau phosphorylation and synthesis

Pei, Jin-Jing, An, Wen-Lin, Zhou, Xin-Wen, Nishimura, Takeshi, Norberg, Jan, Benedikz, Eirikur, Gotz, Juergen and Winblad, Bengt (2006) P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Letters, 580 1: 107-114. doi:10.1016/j.febslet.2005.11.059

Different tau epitopes define Aβ42-mediated tau insolubility

Pennanen, Luis and Gotz, Juergen (2005) Different tau epitopes define Aβ42-mediated tau insolubility. Biochemical and Biophysical Research Communications, 337 4: 1097-1101. doi:10.1016/j.bbrc.2005.09.168

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

David, Della C., Hauptmann, Susanne, Scherping, Isabel, Schuessel, Katrin, Keil, Uta, Rizzu, Patrizia, Ravid, Rivka, Drose, Stefan, Brandt, Ulrich, Muller, Walter E., Eckert, Anne and Gotz, Juergen (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. Journal of Biological Chemistry, 280 25: 23802-23814. doi:10.1074/jbc.M500356200

Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology

David, Della C., Hoerndli, Frederic and Gotz, Juergen (2005) Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology. Progress in Neurobiology, 76 3: 153-168. doi:10.1016/j.pneurobio.2005.07.001

Functional genomics meets neurodegenerative disorders: part II: application and data integration

Hoerndli, Frederic, David, Della C. and Gotz, Juergen (2005) Functional genomics meets neurodegenerative disorders: part II: application and data integration. Progress in Neurobiology, 76 3: 169-188. doi:10.1016/j.pneurobio.2005.07.002

Role of the protein tau in Alzheimer's disease

Götz, Jürgen, Ittner, Lars M. and David, Della C. (2005) Role of the protein tau in Alzheimer's disease. Drug Discovery Today: Disease Mechanisms, 2 4: 395-400. doi:10.1016/j.ddmec.2005.11.008

Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction

Hoerndli, Frédéric J., Toigo, Marco, Schild, Andreas, Gotz, Jürgen and Day, Philip J. (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Analytical Biochemistry, 335 1: 30-41. doi:10.1016/j.ab.2004.08.028

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models

Gotz, Juergen, Schild, Andreas, Hoerndli, Fred and Pennanen, Luis (2004) Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. International Journal of Developmental Neuroscience, 22 7: 453-465. doi:10.1016/j.ijdevneu.2004.07.013

Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy

Gotz, J, Streffer, JR, David, D, Schild, A, Hoerndli, F, Pennanen, L, Kurosinski, P and Chen, F (2004) Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy. Molecular Psychiatry, 9 7: 664-683. doi:10.1038/sj.mp.4001508

Role for glyoxalase I in Alzheimer's disease

Chen, Feng, Wollmer, M. Axel, Hoerndli, Frederic, Munch, Gerald, Kuhla, Bjorn, Rogaev, Evgeny I., Tsolaki, Magdalini, Papassotiropoulos, Andreas and Gotz, Juergen (2004) Role for glyoxalase I in Alzheimer's disease. National Academy of Sciences. Proceedings, 101 20: 7687-7692. doi:10.1073/pnas.0402338101

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice

Pennanen, Luis, Welzl, Hans, D'Adamo, Patrizia, Nitsch, Roger M. and Gotz, Juergen (2004) Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of Disease, 15 3: 500-509. doi:10.1016/j.nbd.2003.11.020

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice

Martens, Ellen, Stevens, Ilse, Janssens, Veerle, Vermeesch, Joris, Gotz, Juergen, Goris, Jozef and Van Hoof , Christine Van (2004) Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice. Journal of Molecular Biology, 336 4: 971-986. doi:10.1016/j.jmb.2003.12.047

Posttranslational modifications of tau - Role in human tauopathies and modeling in transgenic animals

Chen F., David D., Ferrari A. and Gotz J. (2004) Posttranslational modifications of tau - Role in human tauopathies and modeling in transgenic animals. Current Drug Targets, 5 6: 503-515. doi:10.2174/1389450043345236

Transgenic Mice Expressing the Nucleoprotein of Borna Disease Virus in either Neurons or Astrocytes: Decreased Susceptibility to Homotypic Infection and Disease

Rauer, Mathias, Gotz, Jurgen, Schuppli, Daniel, Staeheli, Peter and Hausmann, Jurgen (2004) Transgenic Mice Expressing the Nucleoprotein of Borna Disease Virus in either Neurons or Astrocytes: Decreased Susceptibility to Homotypic Infection and Disease. Journal of Virology, 78 7: 3621-3632. doi:10.1128/JVI.78.7.3621-3632.2004

β-amyloid induces paired helical filament-like tau filaments in tissue culture

Ferrari, Alessandra, Hoerndli, Frederic, Baechi, Thomas, Nitsch, Roger M. and Gotz, Juergen (2003) β-amyloid induces paired helical filament-like tau filaments in tissue culture. Journal of Biological Chemistry, 278 41: 40162-40168. doi:10.1074/jbc.M308243200

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

Kins, S, Kurosinski, P, Nitsch, RM and Gotz, J (2003) Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. American Journal of Pathology, 163 3: 833-843. doi:10.1016/S0002-9440(10)63444-X

Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia

Flechsig, Eckhard, Hegyi, Ivan, Leimeroth, Rainer, Zuniga, Armando, Rossi, Daniela, Cozzio, Antonio, Schwarz, Petra, Rulicke, Thomas, Gotz, Juergen, Aguzzi, Adriano and Weissmann, Charles (2003) Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. EMBO Journal, 22 12: 3095-3101. doi:10.1093/emboj/cdg285

Saitohin gene is not associated with Alzheimer's disease

Streffer, J. R., Papassotiropoulos, A., Kurosinski, P., Signorell, A., Wollmer, M. A., Tsolaki, M., Iakovidou, V., Horndli, F., Bosset, J., Gotz, J., Nitsch, R. M. and Hock, C. (2003) Saitohin gene is not associated with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 74 3: 362-363. doi:10.1136/jnnp.74.3.362

Protein Phosphatases: Transgenic and knockout models of PP2A

Gotz, J. and Schild, A. (2003) Protein Phosphatases: Transgenic and knockout models of PP2A. Methods in Enzymology, 366 390-403. doi:10.1016/S0076-6879(03)66029-5

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A

Schmidt, Karsten, Kins, Stefan, Schild, Andreas, Nitsch, Roger M., Hemmings, Brian A. and Gotz, Juergen (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. European Journal of Neuroscience, 16 11: 2039-2048. doi:10.1046/j.1460-9568.2002.02274.x

Glial cells under physiologic and pathologic conditions

Kurosinski, Pascal, Biol, Dipl and Gotz, Jurgen (2002) Glial cells under physiologic and pathologic conditions. JAMA Neurology, 59 10: 1524-1528. doi:10.1001/archneur.59.10.1524

Neurofibrillary tangle formation in transgenic mouse models of Alzheimer's disease

Chen, F, Nitsch, RM, Gotz, J, van Dorpe, J and Leuven, KU (2002) Neurofibrillary tangle formation in transgenic mouse models of Alzheimer's disease. Neurobiology of Aging, 23 1: S233-S233.

Alzheimer's and Parkinson's disease - overlapping or synergistic pathologies?

Kurosinski, P, Guggisberg, M and Gotz, J (2002) Alzheimer's and Parkinson's disease - overlapping or synergistic pathologies?. Trends in Molecular Medicine, 8 1: 3-5. doi:10.1016/S1471-4914(01)02246-8

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, Stefan, Crameri, Arames, Evans, David R. H., Hemmings, Brian A., Nitsch, Roger M. and Gotz, Juergen (2001) Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. Journal of Biological Chemistry, 276 41: 38193-38200.

Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils

Goetz, J., Chen, F., Van Dorpe, J. and Nitsch, R. M. (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science, 293 5534: 1491-1495. doi:10.1126/science.1062097

Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice

Gotz, J and Nitsch, RM (2001) Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. Neuroreport, 12 9: 2007-2016.

Tau and transgenic animal models

Gotz, J (2001) Tau and transgenic animal models. Brain Research Reviews, 35 3: 266-286. doi:10.1016/S0165-0173(01)00055-8

Human tau transgenic mice - Towards an animal model for neuro- and glialfibrillary lesion formation

Gotz, J, Tolnay, M, Barmettler, R, Ferrari, A, Burki, K, Goedert, M, Probst, A and Nitsch, RM (2001) Human tau transgenic mice - Towards an animal model for neuro- and glialfibrillary lesion formation. Neuropathology and Genetics of Dementia, 487 71-83.

Oligodendroglial tau filament formation in transgenic mice expressing G272V tau

Gotz, Jürgen, Tolnay, Markus, Barmettler, Robi, Chen, Feng, Probst, Alphonse and Nitsch, Roger M. (2001) Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. European Journal of Neuroscience, 13 11: 2131-2140. doi:10.1046/j.0953-816X.2001.01604.x

Tau filament formation in transgenic mice expressing P301L tau

Goetz, Juergen, Chen, Feng, Barmettler, Robi and Nitsch, Roger M. (2001) Tau filament formation in transgenic mice expressing P301L tau. Journal of Biological Chemistry, 276 1: 529-534. doi:10.1074/jbc.M006531200

Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types

Ferrari, A, Ehler, E, Nitsch, RM and Gotz, J (2000) Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types. Febs Letters, 486 2: 121-125. doi:10.1016/S0014-5793(00)02251-1

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

Probst, A, Gotz, J, Wiederhold, KH, Tolnay, M, Mistl, C, Jaton, AL, Hong, M, Ishihara, T, Lee, VMY, Trojanowski, JQ, Jakes, R, Crowther, RA, Spillantini, MG, Burki, K and Goedert, M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathologica, 99 5: 469-481.

Distinct role of protein phosphatase 2A subunit C alpha in the regulation of E-cadherin and beta-catenin during development

Gotz, J, Probst, A, Mistl, C, Nitsch, RM and Ehler, E (2000) Distinct role of protein phosphatase 2A subunit C alpha in the regulation of E-cadherin and beta-catenin during development. Mechanisms of Development, 93 1-2: 83-93. doi:10.1016/S0925-4773(00)00267-7

In vivo analysis of wild-type and FTDP-17 tau transgenic mice

Gotz, J, Barmettler, R, Ferrari, A, Goedert, M, Probst, A and Nitsch, RM (2000) In vivo analysis of wild-type and FTDP-17 tau transgenic mice. Molecular Basis of Dementia, 920 126-133.

The role of protein phosphatase 2A catalytic subunit Cα in embryogenesis: evidence from sequence analysis and localization studies

Goetz, Juergen and Kues, Wilfried (1999) The role of protein phosphatase 2A catalytic subunit Cα in embryogenesis: evidence from sequence analysis and localization studies. Biological Chemistry, 380 9: 1117-1120. doi:10.1515/BC.1999.139

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Gotz J., Probst A., Ehler E., Hemmings B. and Kues W. (1998) Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα. National Academy of Sciences. Proceedings, 95 21: 12370-12375. doi:10.1073/pnas.95.21.12370

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

Shmerling, D, Hegyi, I, Fischer, M, Blattler, T, Brandner, S, Gotz, J, Rulicke, T, Flechsig, E, Cozzio, A, von Mering, C, Hangartner, C, Aguzzi, A and Weissmann, C (1998) Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell, 93 2: 203-214. doi:10.1016/S0092-8674(00)81572-X

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

Li Z.-W., Stark G., Gotz J., Rulicke T., Muller U. and Weissmann C. (1996) Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 93 12: 6158-6162. doi:10.1073/pnas.93.12.6158

Molecular dissection of the paired helical filament

Goedert, M, Spillantini, MG, Jakes, R, Crowther, RA, Cohen, P, Vanmechelen, E, Probst, A, Gotz, J and Burki, K (1995) Molecular dissection of the paired helical filament. Neurobiology of Aging, 16 3: 325-334. doi:10.1016/0197-4580(95)00017-9

Somatodendritic Localization and Hyperphosphorylation of Tau-Protein in Transgenic Mice Expressing the Longest Human Brain Tau-Isoform

Gotz, J, Probst, A, Spillantini, MG, Schafer, T, Jakes, R, Burki, K and Goedert, M (1995) Somatodendritic Localization and Hyperphosphorylation of Tau-Protein in Transgenic Mice Expressing the Longest Human Brain Tau-Isoform. Embo Journal, 14 7: 1304-1313.

Tau-Protein in Alzheimers-Disease

Goedert, M, Jakes, R, Spillantini, MG, Crowther, RA, Cohen, P, Vanmechelen, E, Probst, A, Gotz, J and Burki, K (1995) Tau-Protein in Alzheimers-Disease. Biochemical Society Transactions, 23 1: 80-85.

Fgf5 as a Regulator of the Hair-Growth Cycle - Evidence From Targeted and Spontaneous Mutations

Hebert, JM, Rosenquist, T, Gotz, J and Martin, GR (1994) Fgf5 as a Regulator of the Hair-Growth Cycle - Evidence From Targeted and Spontaneous Mutations. Cell, 78 6: 1017-1025. doi:10.1016/0092-8674(94)90276-3

Nontolerance and Differential Susceptibility to Diabetes in Transgenic Mice Expressing Major Histocompatibility Class-Ii Genes On Pancreatic Beta-Cells

Gotz, J, Eibel, H and Kohler, G (1990) Nontolerance and Differential Susceptibility to Diabetes in Transgenic Mice Expressing Major Histocompatibility Class-Ii Genes On Pancreatic Beta-Cells. European Journal of Immunology, 20 8: 1677-1683. doi:10.1002/eji.1830200809

Differential Utilization of the Same Reading Frame in a Xenopus Homeobox Gene Encodes 2 Related Proteins Sharing the Same Dna-Binding Specificity

Cho, Kwy, Goetz, J, Wright, Cve, Fritz, A, Hardwicke, J and Derobertis, EM (1988) Differential Utilization of the Same Reading Frame in a Xenopus Homeobox Gene Encodes 2 Related Proteins Sharing the Same Dna-Binding Specificity. Embo Journal, 7 7: 2139-2149.

Homeotic-Like Genes in Xenopus-Laevis

Fritz, A, Gotz, J, Martin, G, Salo, E, Wright, J and Derobertis, E (1985) Homeotic-Like Genes in Xenopus-Laevis. Biological Chemistry Hoppe-Seyler, 366 9: 788-788.

Pathogenetic mechanisms in Down Syndrome

Einfeld, S., Goetz, J. and Holsinger, R. M. D. () Pathogenetic mechanisms in Down Syndrome. , 52 813-813. doi:10.1111/j.1365-2788.2008.01119_7.x

SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56

Lesne, Sylvain, Amar, Fatou, Sherman, Mathew, Rush, Travis, Larson, Megan, Chang, Liu, Gotz, Jurgen, Schneider, Julie, Bennett, David, Ashe, Karen and Buisson, Alain (2016). SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56. In: 14th International Athens/Springfield Symposium on Advances In Alzheimer Therapy, Athens, Greece, (S27-S27). Mar 09-12, 2016.

Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy

Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease

Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

The many facets of dementia - basic science and translational strategies

Gotz, Jurgen (2016). The many facets of dementia - basic science and translational strategies. In: Unknown, Unknown, (11-11). Unknown.

Effects of scanning focused ultrasound in an Alzheimer's mouse model

Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (274-275). 23 - 27 August 2015.

Neurotrophin regulation of Alzheimer's disease pathology

Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (208-208). 23-27 August 2015. doi:10.1111/jnc.13188

Novel strategies to target tau and Ab toxicity

Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186

Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's

Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (277-278). 23 - 27 August 2015.

Striatal deficits underlie conflicted patterns of action selection in ageing

Matamales, M., Skrbis, Z., Balleine, B., Goetz, J. and Bertran-Gonzalez, J. (2015). Striatal deficits underlie conflicted patterns of action selection in ageing. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (144-144). 23-27 August 2015. doi:10.1111/jnc.13188

Novel functions of the protein tau in disease

Gotz, Jurgen (2011). Novel functions of the protein tau in disease. In: Neuroscience Research. , , (E26-E26). . doi:10.1016/j.neures.2011.07.111

Convergence of amyloid-β and tau pathologies on mitochondria in vivo

Eckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Götz, Jürgen (2010). Convergence of amyloid-β and tau pathologies on mitochondria in vivo. In: , , (107-114). . doi:10.1007/s12035-010-8109-5

Axonal transport in tau transgenic mouse models

Goetz, J. and Ittner, L. M. (2009). Axonal transport in tau transgenic mouse models. In: Journal of Neurochemistry. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig Germany, (59-59). Jul 11-14, 2009.

Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse

Schroeder, H., Goetz, J., Pilz, K., Kuhlage, S., de Vos, R. A. I., Bauer, T., Selzer, A. and Koehler, C. (2009). Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse. In: New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009. 9th International Conference on Alzheimers and Parkinson's Diseases (AD/PD), Prague Czech Republic, (233-237). Mar 11-15, 2009.

Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice

Rhein, Virginie, Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Droese, Stefan, Brandt, Ulrich, Mueller-Spahn, Franz, Czech, Christian, Goetz, Jurgen and Eckert, Anne (2008). Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice. In: Biochimica Et Biophysica Acta-Bioenergetics. 15th European Bioenergetic Conference, Dublin Ireland, (S85-S86). Jul 19-24, 2008. doi:10.1016/j.bbabio.2008.05.335

Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles

Rhein, V, Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Savaskan, E., Mueller-Spahn, F., Czech, C., Goetz, J. and Eckert, A. (2007). Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles. In: Pharmacopsychiatry. 25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie, Munich Germany, (234-234). Oct 03-06, 2007.

A decade of tau transgenic animal models and beyond

Gotz J., Deters N., Doldissen A., Bokhari L., Ke Y., Wiesner A., Schonrock N. and Ittner L.M. (2007). A decade of tau transgenic animal models and beyond. In: , , (91-103). . doi:10.1111/j.1750-3639.2007.00051.x

Transgenic animal models of Alzheimer's disease

Gotz, J. (2006). Transgenic animal models of Alzheimer's disease. In: European Neuropsychopharmacology. 19th Congress of the European-College-of-Neuropsychopharmacology, Paris France, (S197-S197). Sep 16-20, 2006. doi:10.1016/S0924-977X(06)70110-9

Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro

Pennanen, L, David, D, Hoerndli, F, Kurosinski, P, Chen, F, Schild, A, Ferrari, A, Nitsch, RM and Gotz, J (2004). Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro. In: Neurobiology of Aging. 9th International Conference on Alzheimers Disease and Related Disorders, Philadelphia Pa, (S255-S255). Jul 17-22, 2004. doi:10.1016/S0197-4580(04)80857-1

In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation

Chen, E, Schild, A, Kurosinski, P, Pennanen, L, Hoerndli, E, David, D, Ferrari, A, Nitsch, RM and Gotz, J (2003). In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. In: European Neuropsychopharmacology. 16th Congress of the European-College-of-Neuropsychopharmacology, Prague Czech Republic, (S99-S100). Sep 20-24, 2003.

Amyloid-induced neurofibrillary tangle formation

Gotz, J, Chen, F, Ferrari, A, Kurosinski, P, Schild, A, Nitsch, RM and van Dorpe, J (2002). Amyloid-induced neurofibrillary tangle formation. In: Neurobiology of Aging. , , (S567-S567). .

Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice

Gotz, J, Chen, F and Nitsch, RM (2002). Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice. In: Mapping the Progress of Alzheimer'S and Parkinson'S Disease. 5th International Conference on the Progress in Alzheimers and Parkinsons Disease/9th International Catecholamine Symposium, Kyoto Japan, (139-144). Mar 31-Apr 05, 2001.

The role of beta-amyloid addressed in tau filament-forming mice

Chen, F, Ferrari, A, Nitsch, RM and Gotz, J (2001). The role of beta-amyloid addressed in tau filament-forming mice. In: Journal of Neurochemistry. , , (8-8). .