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Professor Juergen Goetz

Director of CJCADR

Clem Jones Centre for Ageing Dementia Research
Queensland Brain Institute
j.goetz@uq.edu.au

Overview

Professor Jürgen Götz is the Foundation Chair of Dementia Research and Director of the Centre for Ageing Dementia Research (CADR) at the Queensland Brain Institute (QBI), The University of Queensland. Götz studied biochemistry at the University of Basel, and earned his PhD in immunology in the laboratory of Nobel Laureate Georges Köhler at the Max-Planck-Institute in Freiburg, Germany (1989). After postdoctoral work at UCSF and the Preclinical Research Division at Novartis Ltd in Basel, he established his reputation in the Alzheimer’s field as a research group leader at the University of Zürich (1994–2005). From 2005 - 2012, before accepting his new position at the University of Queensland, he has been Chair of Molecular Biology and Director of the Alzheimer’s and Parkinson’s Laboratory at the Brain and Mind Research Institute of the University of Sydney. Götz uses transgenic animal models to contribute to a better understanding of the role of tau and amyloid-beta in Alzheimer’s disease and related dementias.

Qualifications

  • Doctor of Natural Science, Albert Ludwig University of Freiburg

Publications

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Grants

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Supervision

  • The Role of Tau in Mitochondrial Dynamics and Quality Control

    (2018) Doctor Philosophy

  • Analysis of how tau spreads and forms aggregated lesions in Alzheimer¿s disease models

    Doctor Philosophy

  • The role of tyrosine kinases Pyk2, Fyn and the tyrosine phosphatase STEP in neurodegeneration and neurophysiology

    Doctor Philosophy

View all Supervision

Publications

Book Chapter

Journal Article

Conference Publication

  • SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56

    Lesne, Sylvain, Amar, Fatou, Sherman, Mathew, Rush, Travis, Larson, Megan, Chang, Liu, Gotz, Jurgen, Schneider, Julie, Bennett, David, Ashe, Karen and Buisson, Alain (2016). SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56. In: 14th International Athens/Springfield Symposium on Advances In Alzheimer Therapy, Athens, Greece, (S27-S27). Mar 09-12, 2016.

  • Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy

    Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

  • Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease

    Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5

  • The many facets of dementia - basic science and translational strategies

    Gotz, Jurgen (2016). The many facets of dementia - basic science and translational strategies. In: Unknown, Unknown, (11-11). Unknown.

  • Effects of scanning focused ultrasound in an Alzheimer's mouse model

    Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (274-275). 23 - 27 August 2015.

  • Neurotrophin regulation of Alzheimer's disease pathology

    Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (208-208). 23-27 August 2015. doi:10.1111/jnc.13188

  • Novel strategies to target tau and Ab toxicity

    Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186

  • Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's

    Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (277-278). 23 - 27 August 2015.

  • Striatal deficits underlie conflicted patterns of action selection in ageing

    Matamales, M., Skrbis, Z., Balleine, B., Goetz, J. and Bertran-Gonzalez, J. (2015). Striatal deficits underlie conflicted patterns of action selection in ageing. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (144-144). 23-27 August 2015. doi:10.1111/jnc.13188

  • Novel functions of the protein tau in disease

    Gotz, Jurgen (2011). Novel functions of the protein tau in disease. In: Neuroscience Research. , , (E26-E26). . doi:10.1016/j.neures.2011.07.111

  • Convergence of amyloid-β and tau pathologies on mitochondria in vivo

    Eckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Götz, Jürgen (2010). Convergence of amyloid-β and tau pathologies on mitochondria in vivo. In: , , (107-114). . doi:10.1007/s12035-010-8109-5

  • Axonal transport in tau transgenic mouse models

    Goetz, J. and Ittner, L. M. (2009). Axonal transport in tau transgenic mouse models. In: Journal of Neurochemistry. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig Germany, (59-59). Jul 11-14, 2009.

  • Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse

    Schroeder, H., Goetz, J., Pilz, K., Kuhlage, S., de Vos, R. A. I., Bauer, T., Selzer, A. and Koehler, C. (2009). Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse. In: New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009. 9th International Conference on Alzheimers and Parkinson's Diseases (AD/PD), Prague Czech Republic, (233-237). Mar 11-15, 2009.

  • Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice

    Rhein, Virginie, Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Droese, Stefan, Brandt, Ulrich, Mueller-Spahn, Franz, Czech, Christian, Goetz, Jurgen and Eckert, Anne (2008). Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice. In: Biochimica Et Biophysica Acta-Bioenergetics. 15th European Bioenergetic Conference, Dublin Ireland, (S85-S86). Jul 19-24, 2008. doi:10.1016/j.bbabio.2008.05.335

  • Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response

    Gotz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y.-A., Deters, N. and Ittner, L. M. (2008) Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegenerative Diseases, 5 3-4: 179-181. doi:10.1159/000113696

  • Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice

    Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Rhein, Virginie, Muller-Spahn, Franz, Gotz, Jürgen and Muller, Walter E. (2008) Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegenerative Diseases, 5 3-4: 157-159. doi:10.1159/000113689

  • Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles

    Rhein, V, Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Savaskan, E., Mueller-Spahn, F., Czech, C., Goetz, J. and Eckert, A. (2007). Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles. In: Pharmacopsychiatry. 25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie, Munich Germany, (234-234). Oct 03-06, 2007.

  • A decade of tau transgenic animal models and beyond

    Gotz J., Deters N., Doldissen A., Bokhari L., Ke Y., Wiesner A., Schonrock N. and Ittner L.M. (2007). A decade of tau transgenic animal models and beyond. In: , , (91-103). . doi:10.1111/j.1750-3639.2007.00051.x

  • Transgenic animal models of Alzheimer's disease

    Gotz, J. (2006). Transgenic animal models of Alzheimer's disease. In: European Neuropsychopharmacology. 19th Congress of the European-College-of-Neuropsychopharmacology, Paris France, (S197-S197). Sep 16-20, 2006. doi:10.1016/S0924-977X(06)70110-9

  • Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro

    Pennanen, L, David, D, Hoerndli, F, Kurosinski, P, Chen, F, Schild, A, Ferrari, A, Nitsch, RM and Gotz, J (2004). Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro. In: Neurobiology of Aging. 9th International Conference on Alzheimers Disease and Related Disorders, Philadelphia Pa, (S255-S255). Jul 17-22, 2004. doi:10.1016/S0197-4580(04)80857-1

  • In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation

    Chen, E, Schild, A, Kurosinski, P, Pennanen, L, Hoerndli, E, David, D, Ferrari, A, Nitsch, RM and Gotz, J (2003). In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. In: European Neuropsychopharmacology. 16th Congress of the European-College-of-Neuropsychopharmacology, Prague Czech Republic, (S99-S100). Sep 20-24, 2003.

  • S.03.01 In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation

    Chen, F., Schild, A., Kurosinski, P., Pennanen, L., Hoerndli, F., David, D., Ferrari, A., Nitsch, R.M. and Götz, J. (2003). S.03.01 In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. In: , , (S99-S100). . doi:10.1016/s0924-977x(03)91605-1

  • Amyloid-induced neurofibrillary tangle formation

    Gotz, J, Chen, F, Ferrari, A, Kurosinski, P, Schild, A, Nitsch, RM and van Dorpe, J (2002). Amyloid-induced neurofibrillary tangle formation. In: Neurobiology of Aging. , , (S567-S567). .

  • Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice

    Gotz, J, Chen, F and Nitsch, RM (2002). Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice. In: Mapping the Progress of Alzheimer'S and Parkinson'S Disease. 5th International Conference on the Progress in Alzheimers and Parkinsons Disease/9th International Catecholamine Symposium, Kyoto Japan, (139-144). Mar 31-Apr 05, 2001.

  • The role of beta-amyloid addressed in tau filament-forming mice

    Chen, F, Ferrari, A, Nitsch, RM and Gotz, J (2001). The role of beta-amyloid addressed in tau filament-forming mice. In: Journal of Neurochemistry. , , (8-8). .

  • In vivo analysis of wild-type and FTDP-17 tau transgenic mice

    Götz, J., Barmettler, R., Ferrari, A., Goedert, M., Probst, A. and Nitsch, R. M. (2000). In vivo analysis of wild-type and FTDP-17 tau transgenic mice. In: , , (126-133). .

  • Tau protein in Alzheimer's disease

    Goedert, M., Jakes, R., Spillantini, M. G., Crowther, R. A., Cohen, P., Vanmechelen, E., Probst, A., Gotz, J. and Burki, K. (1995). Tau protein in Alzheimer's disease. In: , , (80-85). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Analysis of how tau spreads and forms aggregated lesions in Alzheimer¿s disease models

    Doctor Philosophy — Principal Advisor

  • The role of tyrosine kinases Pyk2, Fyn and the tyrosine phosphatase STEP in neurodegeneration and neurophysiology

    Doctor Philosophy — Principal Advisor

  • The role of de novo protein synthesis in neurodegenerative disease

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Understanding ultrasound mediated blood brain barrier opening as a potential non invasive therapeutic approach in Alzheimer disease

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Synaptic Apoptosis in Alzheimer's Disease

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Dynamic Reorganization of Presynaptic Proteins During Neurotransmission and Neuronal Degeneration

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Dynamics of dendritic spines in early stage in vitro and in vivo models of Alzheimers disease

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Tau-specific immunotherapeutic strategies for the treatment of tauopathies

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • The Role of Microglia in Traumatic Brain Injury

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • New pet imaging agents for the early detection of alzheimers disease

    Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

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ResearcherID: C-2448-2014

ORCID: 0000-0001-8501-7896

Scopus ID: 7006610653

Google Scholar ID:

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