Dr Paul Ebert

Reader

School of Biological Sciences
Faculty of Science

Overview

Molecular mechanisms of oxidative stress toxicity and longevity

Genetic mapping of oxidative stress resistance genes. The fumigant, phosphine, disrupts oxidative metabolism, resulting in the production of reactive oxygen intermediates. This causes the premature ageing and death of targeted pests. Insect pests of stored grain in Australia now exhibit resistance to phosphine at levels more than 200 times the normal lethal dose.

We are using genetic mapping to clone the genes responsible for phosphine resistance in the Lesser Grain Borer.We are also using functional genomics of the model organisms C. elegans to understand the molecular basis of phosphine actionOur genetic studies have recently shown that resistance to phosphine is associated with an extension of lifespan

Qualifications

  • PhD, Wash.state
  • MSc, Wash.
  • BSc, U.C.L.A

Publications

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Grants

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Publications

Featured Publications

Book Chapter

  • Schlipalius, D., Ebert, P. R. and Hunt, G. J. (2008). Honeybee. In Wayne Hunter and Chittaranjan Kole (Ed.), Genome mapping and genomics in arthropods (pp. 1-16) Berlin, Germany: Springer.

Journal Article

Conference Publication

  • Kuang, J., Zuryn, S., Valmas, N., Cha'on, U, Cui, Y.W., Cheng, Q., Tuck, A., Collins, P.J. and Ebert, P.R. (2008). Biochemical mechanisms of phosphine action and resistance. In: Daolin, G., Navarro, S., Jian, Y., Cheng, T., Zuxun, J., Yue, L. and Haipeng, W., Proceedings of the 8th International Conference on Controlled Atmosphere and Fumigation in Stored Products. 8th International Conference on Controlled Atmosphere and Fumigation in Stored Products, Chengdu, China, (55-60). 21-26 September 2008.

  • Schlipalius, D.I., Jagadeesan, R., Mau, Y., Collins, P.J. and Ebert, P.R. (2008). DNA testing for phosphine resistance - the future of resistance monitoring and management. In: Daolin, G., Navarro, S., Jian, Y., Cheng, T., Zuxun, J., Yue, L., Yang, L. and Haipeng, W., Proceedings of the 8th International Conference on Controlled Atmosphere and Fumigation in Stored Products. 8th International Conference on Controlled Atmosphere and Fumigation in Stored Products, Chengdu, China, (595-598). 21-26 September 2008.

  • Miller, V., Oldfield, E. G., O'Brien, M., Hughes, C. P. and Ebert, P. R. (2006). Should peers be the face of first year learning?. In: , Engaging Students. 9th Pacific Rim First Year in Higher Education Conference, Griffith University Gold Coast, Qld, Australia, (). 12-14 July, 2006.

  • Ebert, P. R. (2004). Genomic strategies in the study of nutrition. In: , Nutrition Society of Australia 28th Annual Scientific Meeting. Nutrition Society of Australia 28th Annual Scientific Meeting, Brisbane, ((Abstract)). 11-13 Aug, 2004.

  • Ebert, P. R., Cheng, Q., Valmas, N., Zuryn, S. J., Cha'on, U., Schlipalius, D., Collins, P., Mau, Y., Chen, W., Whan, A. P., Huang, Y. and Chiu, H. (2004). Molecular mechanisms of phosphine toxicity and the genetics of resistence. In: J. LaSalle, M. Patten and M. Zalucki, XXII International Congress of Entomology. Entomology Strength in Diversity, Brisbane, Australia, (29-29). 11-15 August.

  • Schenk, P. M. P., Anderson, J., Badruzsaufari, B., Desmond, O. J., Thomas-Hall, S. R., McGrath, K. C., Timmins, M., Maclean, D. J., Ebert, P. R., Manners, J. and Kazan, K. (2004). Plant defence signaling in Arabidopsis. In: C. Robinson, ComBio 2004. ComBio2004, Perth, Australia, (30). 26-30 September, 2004.

  • Ebert, P. R., Reilly, P. E., Mau, Y. S., Schlipalius, D.I. and Collins, P.J. (2003). The molecular genetics of phosphine resistance in the lesser grain borer and implications for management. In: E.J Wright, M.C. Webb and E. Highley, Proceedings of the Australian Postharvest Technical Conference. Australian Postharvest Technical Conference, Canberra, (152-155). 25-27 June, 2003.

  • Humphries, M. and Ebert, P. R. (1999). A unique D1-like dopamine receptor gene in honey bees shows age related expression in mushroom body intrinsic cells. In: , Social insects at the turn of the millennium: 13th Congress of the International Union for the Study of Social Insects (IUSSI). XIII International Congress of IUSSI: IUSSI 1999, Adelaide, S. Aust., (). 29 December, 1998 - 4 January, 1999.

  • Dutton, P., Mccart, A., Whitehall, V. L. and Ebert, P. R. (1999). Comparative genomic and detailed structural analysis of the GABA neurotransmitter transporter gene family between vertebrates and the invertebrates, Apis Mellifera and C.elegans. In: , Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (). 27-30 September, 1999.

  • Remans, T., Schenk, P. M., Elliot, A. R., Sagi, L., Geering, A. D., McMichael, L. A., Thomas, J.E., Swennen, R. L., Grof, C. P., Manners, J. and Ebert, P.R. (1999). Promoters from Australian Banana streak Badna-Virus (BSV) isolates drive transgene expression in Banana, Sugarcane and Tobacco. In: , Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Wed-04). 27-30 September, 1999.

  • Ebert, P. R., Meadows, B., Humphries, M., Swasdipan, N., Whitehall, V. L. and Doan, T. (1999). Structural features of the biogenic amine receptor genes. In: , Social insects at the turn of the millennium: 13th Congress of the International Union for the Study of Social Insects (IUSSI). XIII International Congress of IUSSI: IUSSI 1999, Adelaide, S. Aust., (). 29 December, 1998 - 4 January, 1999.

Edited Outputs

  • Asia Pacific Journal of Clinical Nutrition (2004) . Edited by P. R. Ebert. Nutrition Society of Australia 28th Annual Scientific Meeting, 11-13 August, Brisbane Convention Centre, Brisbane.

Grants

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Principal Advisor

Completed Supervision