Dr Simon Worrall

Senior Lecturer

School of Chemistry and Molecular Biosciences
Faculty of Science
s.worrall@uq.edu.au
+61 7 336 54630
+61 7 336 54626

Overview

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Qualifications

  • BSc (Hons), University of St Andrews
  • PhD, University of Nottingham

Publications

View all Publications

Supervision

View all Supervision

Publications

Book

Book Chapter

Journal Article

Conference Publication

  • Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. In: Abstracts from the 10th International ISSX Meeting. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, (85-86). 29 September - 03 October 2013.

  • Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption. In: Abstracts from the 37th Annual Scientific Meeting of the Research Society on Alcoholism. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, (232A-232A). 21-25 June, 2014. doi:10.1111/acer.12451

  • Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease. In: Abstracts from the 37th Annual Scientific Meeting of the Research Society on Alcoholism. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, (233A-233A). 21-25 June, 2014. doi:10.1111/acer.12451

  • Richards, S., Perry, A., Dodd, P. R. and Worrall, S. (2012). Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration. In: 2012 ISBRA World Congress. 16th World Congress of the International-Society for Biomedical Research on Alcoholism (ISBRA), Sapporo, Japan, (118A-118A). 9-12 September 2012. doi:10.1111/j.1530-0277.2012.01917.x

  • Preedy, Victor R., Peter Eriksson, C. J., Morris, John B., Salaspuro, Mikko, Emery, Peter, Thornalley, Paul J., Seitz, Helmut K., Rao, Radhakrishna K., Worrall, Simon, Apte, Minoti V., Okamura, Tomonori and Yin, Shih-Jiun (2007). Discussion. In: , , (256-260). .

  • Quertemont, Etienne, Jamal, Mostofa, Peter Eriksson, C. J., Preedy, Victor R., Worrall, Simon, Deitrich, Richard A., Yin, Shih-Jiun and Apte, Minoti V. (2007). Discussion. In: , , (141-144). .

  • Thornalley, Paul J., Worrall, Simon, Niemelä, Onni, Rao, Radhakrishna K., Preedy, Victor R., Apte, Minoti V., Albano, Emanuele and Seitz, Helmut K. (2007). Discussion. In: , , (193-197). .

  • Deitrich, Richard A., Crabb, David W., Salaspuro, Mikko, Peter Eriksson, C. J., Apte, Minoti V., Emery, Peter, Niemelä, Onni, Worrall, Simon, Thornalley, Paul J., Albano, Emanuele, Seitz, Helmut K. and Shukla, Shivendra D. (2007). Discussion. In: , , (16-22). .

  • Seitz, Helmut K., Deitrich, Richard A., Peter Eriksson, C. J., Apte, Minoti V., Preedy, Victor R., Morris, John B., Albano, Emanuele, Worrall, Simon, Emery, Peter, Ren, Jun, Crabb, David W., Salaspuro, Mikko, Quertemont, Etienne, Thornalley, Paul J., Rao, Radhakrishna K., Aranda, Agustin, Okamura, Tomonori, Shukla, Shivendra D., Niemelä, Onni and Jamal, Mostofa (2007). Discussion. In: , , (40-51). .

  • Crabb, David W., Seitz, Helmut K., Emery, Peter, Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Shukla, Shivendra D., Apte, Minoti V., Deitrich, Richard A., Salaspuro, Mikko, Yin, Shih-Jiun, Ren, Jun, Okamura, Tomonori, Eriksson, C. J. Peter, Preedy, Victor R. and Albano, Emanuele (2007). Discussion. In: , , (119-124). .

  • Eriksson, C. J. Peter, Preedy, Victor R., Albano, Emanuele, Salaspuro, Mikko, Seitz, Helmut K., Emery, Peter, Apte, Minoti V., Shukla, Shivendra D., Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Niemelä, Onni, Crabb, David W. and Ren, Jun (2007). Discussion. In: , , (177-182). .

  • Worrall, Simon, Eriksson, C. J. Peter, Preedy, Victor R., Seitz, Helmut K., Salaspuro, Ville, Salaspuro, Mikko, Apte, Minoti V., Rao, Radhakrishna K., Morris, John B., Thornalley, Paul J. and Ren, Jun (2007). Discussion. In: , , (133-136). .

  • Worrall, Simon (2007). General discussion. In: Acetaldehyde-related pathology: Bridging the trans-disciplinary divide. Symposium on Acetaldehyde-related pathology: Bridging the Trans-disciplinary Divide, London, UK, (198-199). 5-7 September 2006.

  • Preedy, Victor R., Hashimoto, Kijiro, Hirano, Makoto, Hunter, Ross, Nakahara, Tatsuo, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2006). Cellular and molecular changes in rat models of alcoholic cardiomyopathy. In: Abstracts of the International Society for Biomedical Research on Alcoholism 2006 World Congress on Alcohol Research. World Congress on Alcohol Research, Sydney, Australia, (113A-113A). 10-13 Septmeber 2006. doi:10.1111/j.1530-0277.2006.00197.x

  • Perry, Anthony, Dodd, Peter and Worrall, Simon (2006). Detection of elevated protein modification in alcoholic cerebellar degeneration. In: Alcoholism: Clinical and Experimental Research. 29th Annual Meeting of Research Society on Alcoholism, Sydney, Australia, (149A-149A). 10-13 September, 2006. doi:10.1111/j.1530-0277.2006.00197.x

  • Perry, Anthony, Dodd, Peter R. and Worrall, Simon (2006). Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration. In: Alcoholism Clinical and Experimental Research: 29th Annual Meeting of the Research Society on Alcoholism. 29th Annual Meeting of the Research Society on Alcoholism ( RSA 2006), Baltimore, MD, USA, (218A-218A). 23rd- 29th June, 2006. doi:10.1111/j.1530-0277.2006.00150.x

  • Worrall, Simon (2006). Hepatic adduct levels do not predict the levels of extrahepatic modification. In: Alcoholism-Clinical And Experimental Research: World Congress on Alcohol Research (ISBRA 2006). World Congress on Alcohol Research (ISBRA 2006), Sydney, Australia, (149A-149A). 10 - 13 September 2006. doi:10.1111/j.1530-0277.2006.00197.x

  • Freeman, Thomas L., Tuma, Dean J., Thiele, Geoffrey M., Klassen, Lynell W., Worrall, Simon, Niemela, Onni, Parkkila, Seppo, Emery, Peter W. and Preedy, Victor R. (2005). Recent advances in alcohol-induced adduct formation. In: Proceedings of the 12th International Congress of the International Society for Biomedical Research on Alcoholism. 12th International Congress of the International Society for Biomedical Research on Alcoholism, Heidelberg, Germany, (1310-1316). 29 September-2 October 2004. doi:10.1097/01.ALC.0000171484.52201.52

  • Freeman, TL, Klassen, LW, Worrall, S, Sorrell, MF, Tuma, DJ and Thiele, GM (2004). Adduct chemistry and mechanisms of adduct formation.. In: Alcoholism-Clinical and Experimental Research. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, (67A-67A). Sep 29-Oct 02, 2004. doi:10.1097/00000374-200408002-00363

  • Worrall, S (2004). Adduct formation in the liver.. In: Alcoholism-Clinical and Experimental Research. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, (67A-67A). Sep 29-Oct 02, 2004. doi:10.1097/00000374-200408002-00365

  • Preedy, VR, Emery, P, Niemela, O, Parkkila, S, Peters, TJ and Worrall, S (2004). Alcoholic skeletal muscle myopathy: A role for protein adducts?. In: Alcoholism-Clinical and Experimental Research. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, (68A-68A). Sep 29-Oct 02, 2004. doi:10.1097/00000374-200408002-00367

  • Worrall, S (2004). Liver adduct formation does not predict adduct levels in extrahepatic tissues.. In: Alcoholism-Clinical and Experimental Research. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, (8A-8A). Sep 29-Oct 02, 2004. doi:10.1097/00000374-200408002-00010

  • Preedy, VR, Peters, TJ, Adachi, J, Ahmed, S, Mantle, D, Niemela, O, Parkkila, S and Worrall, S (2001). Pathogenic mechanisms in alcoholic myopathy. In: Agarwal, DP and Seitz, HK, Alcohol in Health and Disease. International Titisee Symposium on Health Effects of Alcohol Intake, Titisee Germany, (243-259). Dec 09-12, 1999.

  • Worrall, S (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. In: Wurst, FM, New and Upcoming Markers of Alcohol Consumption. 11th World Congress of Psychiatry, Hamburg Germany, (93-110). Aug 06-11, 1999.

  • Niemlea, O., Parkkila, S. and Worrall, S. (2000). Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat. In: Alcoholism: Clinical and Experimental Research. 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, (S6.3). 2-8 July, 2000.

  • Worrall, S. (2000). Studies on protein modification by ethanol metabolites in alcohol abuse. In: W. C. Hodgson and R. E. Loicano, Proceedings of ASCEPT. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, Melbourne, (x-x). 3-6 December 2000.

  • Swagell, C. D., Rothnagel, J. A. and Worrall, S. (2000). The effect of keratin mutants on hepatocytes metabolising ethanol in culture. In: 10th Congress of the International Society for Biomedical Research in Alcoholism. 10th Congress of the International Society for Biomedical Research on Alcoholism: ISBRA 2000, Yokohama, Japan, (). 2-8 July 2000.

  • Worrall, Simon (2000). The formation and clearance of MAA adducts in ethanol-fed rats. In: Alcoholism: Clinical and Experimental Research: RSA/ISBRA Abstracts. 10th Congress of the International Society for Biomedical Reseach on Alcoholism, Yokohama, Japan, (WS3:3). 2-8 July, 2000. doi:10.1111/(ISSN)1530-0277

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. In: Alcohol and Alcoholism. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, (255-260). Jun 17-22, 1990.

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins. In: Alcohol and Alcoholism. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, (261-264). Jun 17-22, 1990.

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. In: Biochemical Society Transactions. , , (678-679). . doi:10.1042/bst0180678

  • Williamson, RA, Worrall, S and Strange, PG (1987). Partial-Purification of D2 Dopamine-Receptors From Bovine Brain. In: Biochemical Society Transactions. , , (1155-1156). . doi:10.1042/bst0151155

  • Worrall, S, Williamson, RA and Strange, PG (1986). Purification of D2-Dopamine Receptors From Bovine Brain. In: Biochemical Society Transactions. , , (1138-1139). . doi:10.1042/bst0141138

  • Worrall, S, Williamson, R and Strange, PG (1986). Partial-Purification of D2-Dopamine Receptors From Bovine Brain. In: Biological Chemistry Hoppe-Seyler. , , (1126-1126). .

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

Completed Supervision