The functional architecture of a unique family of lipid droplet proteins (2023–2026)
Abstract:
Eukaryotic cells are distinguished by the presence of membrane-bound compartments called organelles. This
project will use structural biology to determine how essential proteins called sorting nexins (SNXs) regulate
membrane interactions required for lipid droplet formation. These interactions are essential for life, controlling
protein and lipid homeostasis needed for cell survival. The major outcome of this proposal will be a fundamental
understanding of how SNXs control this process, and the work will significantly strengthen our international
collaboration in this emerging area. The knowledge has potential future translation in the treatment of
neurodegenerative disorders where dysregulation of these proteins is known to cause disease.