Dr Yousuf Mohammed

Research Officer

The University of Queensland Diamantina Institute
Faculty of Medicine
y.mohammed@uq.edu.au
+61 7 344 37485

Overview

Dr Yousuf Mohammed completed his PhD in pharmaceutics and skin drug delivery under the guidance of Associate prof Heather Benson, Prof Michael Roberts and Associate prof Tarl Prow. He has been working within the field of skin delivery at the Therapeutics Research Centre, University of Queensland - School of Medicine since 2012. His current research includes managing a US FDA funded project (Co-investigator) which aims to improve current regulatory guidelines for topical and transdermal semisolid products. Over the last 6 years his work has been focused on skin penetration and skin toxicology of drugs and xenobiotics including nanoparticulate materials.

Research Interests

  • Characterization of Critical Quality Attributes for Semisolid Topical Drug Products
    This US FDA funded project aims to understand the formulation-drug-skin interactions. Certain physicochemical attributes of a pharmaceutical product can be deemed as Critical Quality Attributes based on their influence of the product performance. This 5 year project goes into 16 different quality attributes and tests for their role in the performance of topical products using 22 different tests and numerous instruments and methods.

Research Impacts

Working on the US FDA project over the last two years has given an opportunity to showcase real world translational research. The work Yousuf and team has done has led to FDA guidance for Acyclovir creams which highlight the novel methods developed as a part of the work carried out locally in Brisbane in between TRI and other labs in the St Lucia campus.

Role of dispensers on physicochemical properties of the cream when dispensed. Difference in product performance upon dispensing from different dispensers was first identified and reported by our group and the change in cream product guidance based on this work is one of the biggest achievements. Our work over the last couple of years and specifically in the current year (July 2016- June 2017) has also identified skin and drug properties that determine product performance. Of special mention is our work on testing IVPT performance with different doses, different skin membrane types and different sampling protocols and different study durations. This a part of grant’s Aim 3 where we proposed to develop ideal IVPT conditions based on careful literature review as well as clearly thought-out experiments to investigate each parameter that can effect a products performance. Our IVPT studies have also included developing in-use product application and testing protocols and have assessed direct comparisons of CQAs with product performance.

Qualifications

  • Doctor of Philosophy, Curtin University
  • Master of Pharmacy, Curtin University

Publications

  • Roberts, M. S., Mohammed, Y., Pastore, M. N., Namjoshi, S., Yousef, S., Alinaghi, A., Haridass, I. N., Abd, E., Leite-Silva, V. R., Benson, H. A. E. and Grice, J. E. (2017) Topical and cutaneous delivery using nanosystems. Journal of Controlled Release, 247 86-105. doi:10.1016/j.jconrel.2016.12.022

  • Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017) A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87 1005-1011. doi:10.1016/j.bios.2016.09.067

  • Abd, Eman, Yousef , Shereen A., Pastore, Michael N., Telaprolu, Krishna, Mohammed, Yousuf H., Namjoshi, Sarika, Grice, Jeffrey E. and Roberts, Michael S. (2016) Skin models for the testing of transdermal drugs. Clinical Pharmacology: Advances and Applications, 8 163-176. doi:10.2147/CPAA.S64788

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Benson, H. A. E., Mohammed, Y., Grice, J. E. and Roberts, M. S. (2016). Formulation effects on topical nanoparticle penetration. In Michael R. Hamblin, Pinar Avci and Tarl W. Prow (Ed.), Nanoscience in dermatology (pp. 115-126) Amsterdam, The Netherlands: Academic Press. doi:10.1016/B978-0-12-802926-8.00009-4

  • Prow, T. W., Mohammed, Y. H., Ansaldo, A. B. and Benson, H. A. E. (2014). Topical microneedle drug delivery enhanced with magnetophoresis. In Robert Chilcott and Keith R. Brain (Ed.), Advances in dermatological sciences (pp. 169-177) Piccadilly, London, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849734639-00169

Journal Article

PhD and MPhil Supervision

Current Supervision