Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.
Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”
Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
Journal Article: Is glycogen an important constituent of human milk?
Mou, Jing-Yi, Wang, Zi-Yi, Ma, Zhang-Wen, Liu, Qing-Hua, Sullivan, Mitchell A., Liu, Zhao and Wang, Liang (2023). Is glycogen an important constituent of human milk?. Journal of Food Composition and Analysis, 124 105719, 1. doi: 10.1016/j.jfca.2023.105719
Journal Article: Comparing different techniques for obtaining molecular size distributions of glycogen
Wan, Yujun, Chua, Sheena M.H., Yao, Yin, Adler, Lewis, Navarro, Marta, Roura, Eugeni, Tilley, Richard D., Li, Changfeng, Nilsson, Lars, Gilbert, Robert G. and Sullivan, Mitchell A. (2023). Comparing different techniques for obtaining molecular size distributions of glycogen. European Polymer Journal, 201 112518, 112518. doi: 10.1016/j.eurpolymj.2023.112518
MitoKhondrion: Decreasing COVID-19 mortality by increasing the functioning of our cell's powerhouses
(2021–2024) Advance Queensland Industry Research Fellowships
Exploring the Role of Glycogen Structure in Type 2 Diabetes
(2015–2019) NHMRC Early Career Fellowships
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Doctor Philosophy
The Analysis of Liver Glycogen Structure and its Implication in Various Diseases
(2023) Doctor Philosophy
Study of the structure of glycogen and potential drug target for diabetes
Doctor Philosophy
Unravelling the role of glycogen in diabetic kidney disease
Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.
Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.
Aims:
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
Is glycogen an important constituent of human milk?
Mou, Jing-Yi, Wang, Zi-Yi, Ma, Zhang-Wen, Liu, Qing-Hua, Sullivan, Mitchell A., Liu, Zhao and Wang, Liang (2023). Is glycogen an important constituent of human milk?. Journal of Food Composition and Analysis, 124 105719, 1. doi: 10.1016/j.jfca.2023.105719
Comparing different techniques for obtaining molecular size distributions of glycogen
Wan, Yujun, Chua, Sheena M.H., Yao, Yin, Adler, Lewis, Navarro, Marta, Roura, Eugeni, Tilley, Richard D., Li, Changfeng, Nilsson, Lars, Gilbert, Robert G. and Sullivan, Mitchell A. (2023). Comparing different techniques for obtaining molecular size distributions of glycogen. European Polymer Journal, 201 112518, 112518. doi: 10.1016/j.eurpolymj.2023.112518
Cao, Peng, Wang, Yi, Zhang, Cong, Sullivan, Mitchell A., Chen, Wen, Jing, Xiang, Yu, Huifan, Li, Fei, Wang, Qu, Zhou, Zhongshi, Wang, Qi, Tian, Wen, Qiu, Zhenpeng and Luo, Lianxiang (2023). Quercetin ameliorates non-alcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy. The Journal of Nutritional Biochemistry, 120 109414, 109414. doi: 10.1016/j.jnutbio.2023.109414
Pharmacoeconomic evaluation of original and generic temozolomide capsules in the treatment of glioma
Gu, Ming, Diao, Changdong, Sullivan, Mitchell A., Zhu, Haixia, Yuan, Qi, Liu, Jinmei, Li, Shijun, Zhang, Yu, Deng, Bin and Shi, Chen (2023). Pharmacoeconomic evaluation of original and generic temozolomide capsules in the treatment of glioma. Intelligent Pharmacy, 1 (1), 26-31. doi: 10.1016/j.ipha.2023.04.006
Cao, Peng, Zhang, Qilin, Wu, Sanlan, Sullivan, Mitchell A., Huang, Yifei, Gong, Weijing, Lv, Yongning, Zhai, Xuejia and Zhang, Yu (2023). Baseline differences in metabolic profiles of patients with lung squamous cell carcinoma responding or not responding to treatment with nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Acta Materia Medica, 2 (3), 347-356. doi: 10.15212/amm-2023-0027
Cao, Peng, Yue, Ming, Cheng, Yuanlei, Sullivan, Mitchell A., Chen, Wen, Yu, Huifan, Li, Fei, Wu, Sanlan, Lv, Yongning, Zhai, Xuejia and Zhang, Yu (2023). Naringenin prevents non-alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet-fed mice. Food Science and Nutrition, 11 (12), 7826-7840. doi: 10.1002/fsn3.3700
The fragility of liver glycogen from humans with type 2 diabetes: A pilot study
Wang, Ziyi, Min, Xiaobo, Hu, Zhenxia, Sullivan, Mitchell A., Tang, Yong, Wang, Liang, Gilbert, Robert G., Shi, Chen and Deng, Bin (2022). The fragility of liver glycogen from humans with type 2 diabetes: A pilot study. International Journal of Biological Macromolecules, 221, 83-90. doi: 10.1016/j.ijbiomac.2022.08.212
Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency
Nitschke, Silvia, Sullivan, Mitchell A., Mitra, Sharmistha, Marchioni, Charlotte R., Lee, Jennifer P. Y., Smith, Brandon H., Ahonen, Saija, Wu, Jun, Chown, Erin E., Wang, Peixiang, Petković, Sara, Zhao, Xiaochu, DiGiovanni, Laura F., Perri, Ami M., Israelian, Lori, Grossman, Tamar R., Kordasiewicz, Holly, Vilaplana, Francisco, Iwai, Kazuhiro, Nitschke, Felix and Minassian, Berge A. (2022). Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency. Brain, 145 (7), 2361-2377. doi: 10.1093/brain/awac017
Tan, Jingxuan, Li, Xixuan, Zhu, Ying, Sullivan, Mitchell A., Deng, Bin, Zhai, Xuejia and Lu, Yongning (2022). Antidepressant Shugan Jieyu Capsule alters gut microbiota and intestinal microbiome function in rats with chronic unpredictable mild stress -induced depression. Frontiers in Pharmacology, 13 828595, 1-17. doi: 10.3389/fphar.2022.828595
Young Seo, Gi, Neal, Elliott S., Han, Felicity, Vidovic, Diana, Nooru‐Mohamed, Fathima, Dienel, Gerald A., Sullivan, Mitchell A. and Borges, Karin (2022). Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy. Epilepsia Open, 7 (2), 361-367. doi: 10.1002/epi4.12599
The effect of high-amylose resistant starch on the glycogen structure of diabetic mice
Wang, Ziyi, Hu, Zhenxia, Deng, Bin, Gilbert, Robert G. and Sullivan, Mitchell A. (2022). The effect of high-amylose resistant starch on the glycogen structure of diabetic mice. International Journal of Biological Macromolecules, 200, 124-131. doi: 10.1016/j.ijbiomac.2021.12.071
Liver fibrosis alters the molecular structures of hepatic glycogen
Wan, Yujun, Hu, Zhenxia, Liu, Qinghua, Wang, Liang, Sullivan, Mitchell A. and Gilbert, Robert G. (2022). Liver fibrosis alters the molecular structures of hepatic glycogen. Carbohydrate Polymers, 278 118991, 118991. doi: 10.1016/j.carbpol.2021.118991
The Extraction of Liver Glycogen Molecules for Glycogen Structure Determination
Wang, Ziyi, Liu, Qinghua, Wang, Liang, Gilbert, Robert G. and Sullivan, Mitchell A. (2022). The Extraction of Liver Glycogen Molecules for Glycogen Structure Determination. Journal of Visualized Experiments, 2022 (180) e63088. doi: 10.3791/63088
Xie, Jiyi, Zhang, Cong, Li, Shijun, Dai, Rong, Sullivan, Mitchell A., Deng, Bin, Xu, Qiling, Wang, Jinglin, Shi, Chen and Zhang, Yu (2022). Efficacy and safety of thalidomide as a pre-medication of Chemotherapy-Induced Nausea and Vomiting (CINV) following Highly Emetogenic Chemotherapy (HEC): a systematic review and meta-analysis. Frontiers in Oncology, 11 818839. doi: 10.3389/fonc.2021.818839
A review on the structure and anti-diabetic (type 2) functions of β-glucans
Wan, Yujun, Xu, Xiaojuan, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). A review on the structure and anti-diabetic (type 2) functions of β-glucans. Foods, 11 (1) 57, 57. doi: 10.3390/foods11010057
Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308
Steane, Sarah E., Fielding, Arree M., Kent, Nykola L., Andersen, Isabella, Browne, Daniel J., Tejo, Ellen N., Gårdebjer, Emelie M., Kalisch‐Smith, Jacinta I., Sullivan, Mitchell A., Moritz, Karen M. and Akison, Lisa K. (2021). Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta. Alcoholism: Clinical and Experimental Research, 45 (10) acer.14685, 2130-2146. doi: 10.1111/acer.14685
Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081
Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis
Zheng, Ziming, Pan, Xianglin, Wang, Haoyu, Wu, Zhijing, Sullivan, Mitchell A., Liu, Yuxuan, Liu, Junxi, Wang, Kaiping and Zhang, Yu (2021). Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis. Journal of Agricultural and Food Chemistry, 69 (26) acs.jafc.1c00349, 7344-7352. doi: 10.1021/acs.jafc.1c00349
Optimization of liver glycogen extraction when considering the fine molecular structure
Wang, Ziyi, Liu, Qinghua, Wang, Liang, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). Optimization of liver glycogen extraction when considering the fine molecular structure. Carbohydrate Polymers, 261 117887, 1-11. doi: 10.1016/j.carbpol.2021.117887
Comprehensive landscape of heparin therapy for COVID-19
Shi, Chen, Tingting, Wu, Li, Jin-Ping, Sullivan, Mitchell A., Wang, Cong, Wang, Hanxiang, Deng, Bin and Zhang, Yu (2021). Comprehensive landscape of heparin therapy for COVID-19. Carbohydrate Polymers, 254 117232, 117232. doi: 10.1016/j.carbpol.2020.117232
The importance of glycogen molecular structure for blood glucose control
Nawaz, Asad, Zhang, Peng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). The importance of glycogen molecular structure for blood glucose control. iScience, 24 (1) 101953, 101953. doi: 10.1016/j.isci.2020.101953
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health
Wali, Jibran A., Milner, Annabelle J., Luk, Alison W. S., Pulpitel, Tamara J., Dodgson, Tim, Facey, Harrison J. W., Wahl, Devin, Kebede, Melkam A., Senior, Alistair M., Sullivan, Mitchell A., Brandon, Amanda E., Yau, Belinda, Lockwood, Glen P., Koay, Yen Chin, Ribeiro, Rosilene, Solon-Biet, Samantha M., Bell-Anderson, Kim S., O’Sullivan, John F., Macia, Laurence, Forbes, Josephine M., Cooney, Gregory J., Cogger, Victoria C., Holmes, Andrew, Raubenheimer, David, Le Couteur, David G. and Simpson, Stephen J. (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3 (6), 810-828. doi: 10.1038/s42255-021-00393-9
Zhang, Qilin, Liu, Xiaocui, Sullivan, Mitchell A., Shi, Chen and Deng, Bin (2021). Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice. Oxidative Medicine and Cellular Longevity, 2021 7958021, 1-15. doi: 10.1155/2021/7958021
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis
Lee, Mardiana, Harley, Geoff, Katerelos, Marina, Gleich, Kurt, Sullivan, Mitchell A., Laskowski, Adrienne, Coughlan, Melinda, Fraser, Scott A., Mount, Peter F. and Power, David A. (2020). Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis. Scientific Reports, 10 (1) 14531. doi: 10.1038/s41598-020-71475-z
Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu and Hooper, John D. (2020). Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation. Frontiers in Oncology, 10 592455, 592455. doi: 10.3389/fonc.2020.592455
Liu, Xiaocui, Wang, Kaiping, Zhou, Jing, Sullivan, Mitchell A., Liu, Yage, Gilbert, Robert G. and Deng, Bin (2020). Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice. Carbohydrate Polymers, 243 116435, 116435. doi: 10.1016/j.carbpol.2020.116435
Polyglucosan body structure in Lafora disease
Brewer, M. Kathryn, Putaux, Jean-Luc, Rondon, Alberto, Uittenbogaard, Annette, Sullivan, Mitchell A. and Gentry, Matthew S. (2020). Polyglucosan body structure in Lafora disease. Carbohydrate Polymers, 240 116260, 1-14. doi: 10.1016/j.carbpol.2020.116260
Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869
Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”. International Journal of Biological Macromolecules, 144, 1043-1044. doi: 10.1016/j.ijbiomac.2019.05.183
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027)). International Journal of Biological Macromolecules, 142, 889-890. doi: 10.1016/j.ijbiomac.2019.11.160
GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease
Chown, Erin E., Wang, Peixiang, Zhao, Xiaochu, Crowder, Justin J., Strober, Jordan W., Sullivan, Mitchell A., Xue, Yunlin, Bennett, Cody S., Perri, Ami M., Evers, Bret M., Roach, Peter J., Depaoli-Roach, Anna A., Akman, H. Orhan, Pederson, Bartholomew A. and Minassian, Berge A. (2020). GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. Annals of Clinical and Translational Neurology, 7 (11) acn3.51211, 2186-2198. doi: 10.1002/acn3.51211
Some molecular structural features of glycogen in the kidneys of diabetic rats
Wang, Ziyi, Liu, Qinghua, Wang, Liang, Tan, Xinle, Deng, Bin, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2019). Some molecular structural features of glycogen in the kidneys of diabetic rats. Carbohydrate Polymers, 229 115526, 115526. doi: 10.1016/j.carbpol.2019.115526
Glucose and glycogen in the diabetic kidney: heroes or villains?
Sullivan, Mitchell A. and Forbes, Josephine M. (2019). Glucose and glycogen in the diabetic kidney: heroes or villains?. EBioMedicine, 47, 590-597. doi: 10.1016/j.ebiom.2019.07.067
Cao, Peng, Zhang, Yu, Huang, Zi, Sullivan, Mitchell A., He, Zihao, Wang, Jinglin, Chen, Zehong, Hu, Huiping and Wang, Kaiping (2019). The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy. Molecular Nutrition and Food Research, 63 (18) 1801255, 1801255. doi: 10.1002/mnfr.201801255
Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Tan, Xinle, Deng, Bin, Gilbert, Robert G. and Li, Cheng (2019). Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility. International Journal of Biological Macromolecules, 128, 665-672. doi: 10.1016/j.ijbiomac.2019.01.186
Li, Cheng, Gan, Hua, Tan, Xinle, Hu, Zhenxia, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2019). Effects of active ingredients from traditional Chinese medicines on glycogen molecular structure in diabetic mice. European Polymer Journal, 112, 67-72. doi: 10.1016/j.eurpolymj.2018.12.039
Sullivan, Mitchell A., Nitschke, Silvia, Skwara, Evan P., Wang, Peixiang, Zhao, Xiaochu, Pan, Xiao S., Chown, Erin E., Wang, Travis, Perri, Ami M., Lee, Jennifer P.Y., Vilaplana, Francisco, Minassian, Berge A. and Nitschke, Felix (2019). Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases. Cell Reports, 27 (5), 1334-1344.e6. doi: 10.1016/j.celrep.2019.04.017
Exploring glycogen biosynthesis through Monte Carlo simulation
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2018). Exploring glycogen biosynthesis through Monte Carlo simulation. International Journal of Biological Macromolecules, 116, 264-271. doi: 10.1016/j.ijbiomac.2018.05.027
Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139)). International Journal of Biological Macromolecules, 115, 1269-1269. doi: 10.1016/j.ijbiomac.2018.04.168
Diurnal changes of glycogen molecular structure in healthy and diabetic mice
Hu, Zhenxia, Deng, Bin, Tan, Xinle, Gan, Hua, Li, Cheng, Nada, Sharif S., Sullivan, Mitchell A., Li, Jialun, Jiang, Xiaoyin, Li, Enpeng and Gilbert, Robert G. (2018). Diurnal changes of glycogen molecular structure in healthy and diabetic mice. Carbohydrate Polymers, 185, 145-152. doi: 10.1016/j.carbpol.2018.01.003
Proteomic investigation of the binding agent between liver glycogen beta particles
Tan, Xinle, Sullivan, Mitchell A., Nada, Sharif S., Deng, Bin, Schulz, Benjamin L. and Gilbert, Robert G. (2018). Proteomic investigation of the binding agent between liver glycogen beta particles. ACS Omega, 3 (4), 3640-3645. doi: 10.1021/acsomega.8b00119
Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules, 111, 1133-1139. doi: 10.1016/j.ijbiomac.2018.01.139
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
Zhuang, Aowen, Yap, Felicia Y. T., Bruce, Clinton, Leung, Chris, Plan, Manuel R., Sullivan, Mitchell A., Herath, Chandana, McCarthy, Domenica, Sourris, Karly C., Kantharidis, Phillip, Coughlan, Melinda T., Febbraio, Mark A. , Hodson, Mark P., Watt, Matthew J., Angus, Peter, Schulz, Benjamin L. and Forbes, Josephine M. (2017). Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Scientific Reports, 7 (1) 12292, 12292. doi: 10.1038/s41598-017-12548-4
Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan
Sullivan, Mitchell A., Nitschke, Silvia, Steup, Martin, Minassian, Berge A. and Nitschke, Felix (2017). Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan. International Journal of Molecular Sciences, 18 (8) 1743, 1743. doi: 10.3390/ijms18081743
Lack of glycogenin causes glycogen accumulation and muscle function impairment
Testoni, Giorgia, Duran, Jordi, Garcia-Rocha, Mar, Vilaplana, Francisco, Serrano, Antorio L., Sebastian, David, Lopez-Soldado, Iliana, Sullivan, Mitchell A., Slebe, Felipe, Vilaseca, Marta, Munoz-Canoves, Pura and Guinovart, Joan J. (2017). Lack of glycogenin causes glycogen accumulation and muscle function impairment. Cell Metabolism, 26 (1), 256-266. doi: 10.1016/j.cmet.2017.06.008
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease
Nitschke, Felix, Sullivan, Mitchell A., Wang, Peixiang, Zhao, Xiaochu, Chown, Erin E., Perri, Ami M., Israelian, Lori, Juana-Lopez, Lucia, Bovolenta, Paola, Rodriguez de Cordoba, Santiago, Steup, Martin and Minassian, Berge A. (2017). Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease. EMBO Molecular Medicine, 9 (7), 906-917. doi: 10.15252/emmm.201707608
Implications for biological function of lobe dependence of the molecular structure of liver glycogen
Hu, Zhenxia, Tan, Xinle, Deng, Bin, Gan, Hua, Jiang, Xiaoyin, Wang, Kai, Li, Cheng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2017). Implications for biological function of lobe dependence of the molecular structure of liver glycogen. European Polymer Journal, 90, 105-113. doi: 10.1016/j.eurpolymj.2017.03.009
Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver
Tan, Xinle, Gao, Fei, Su, Hexiu, Gong, Yajun, Zhang, Jie, Sullivan, Mitchell A. and Chen, Jiachun (2017). Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver. Scientific Reports, 7 (1) 43556, 1-6. doi: 10.1038/srep43556
Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes
Jiang, Xiaoyin, Zhang, Peng, Li, Shihan, Tan, Xinle, Hu, Zhenxia, Deng, Bin, Wang, Kai, Li, Cheng, Sullivan, Mitchell A., Li, Enpeng and Gilbert, Robert G. (2016). Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes. European Polymer Journal, 82, 175-180. doi: 10.1016/j.eurpolymj.2016.07.017
A new non-degradative method to purify glycogen
Tan, Xinle, Sullivan, Mitchell A., Gao, Fei, Li, Shihan, Schulz, Benjamin L. and Gilbert, Robert G. (2016). A new non-degradative method to purify glycogen. Carbohydrate Polymers, 147, 165-170. doi: 10.1016/j.carbpol.2016.04.009
Molecular structure of human-liver glycogen
Deng, Bin, Sullivan, Mitchell A., Chen, Cheng, Li, Jialun, Powell, Prudence O., Hu, Zhenxia and Gilbert, Robert G. (2016). Molecular structure of human-liver glycogen. Plos One, 11 (3) e0150540, e0150540. doi: 10.1371/journal.pone.0150540
Powell, Prudence O., Sullivan, Mitchell A., Sheehy, Joshua J., Schulz, Benjamin L., Warren, Frederick J. and Gilbert, Robert G. (2015). Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles. PLoS One, 10 (7) e0134065, e0134065. doi: 10.1371/journal.pone.0134065
Deng, Bin, Sullivan, Mitchell A., Wu, Alex Chi, Li, Jialun, Chen, Cheng and Gilbert, Robert G. (2015). The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen. Biomacromolecules, 16 (6), 1870-1872. doi: 10.1021/acs.biomac.5b00459
Molecular structure of glycogen in diabetic liver
Deng, Bin, Sullivan, Mitchell A., Li, Jialun, Tan, Xinle, Zhu, Chengjun, Schulz, Benjamin L. and Gilbert, Robert G. (2015). Molecular structure of glycogen in diabetic liver. Glycoconjugate Journal, 32 (3-4), 113-118. doi: 10.1007/s10719-015-9578-6
A rapid extraction method for glycogen from formalin-fixed liver
Sullivan, Mitchell A., Li, Shihan, Aroney, Samuel T.N., Deng, Bin, Li, Cheng, Roura, Eugeni, Schulz, Benjamin L., Harcourt, Brooke E., Forbes, Josephine M. and Gilbert, Robert G. (2015). A rapid extraction method for glycogen from formalin-fixed liver. Carbohydrate Polymers, 118, 9-15. doi: 10.1016/j.carbpol.2014.11.005
Powell, Prudence O., Sullivan, Mitchell A., Sheehy, Joshua J., Schulz, Benjamin L., Warren, Frederick J. W. and Gilbert, Robert G. (2015). Acid Hydrolysis and Molecular Density of Phytoglycogen and Liver Glycogen Helps Understand the Bonding in Glycogen α (Composite) Particles.. PLoS One, 10 (3) e0121337, e0121337-e0121337. doi: 10.1371/journal.pone.0121337
Sullivan, Mitchell A., Harcourt, Brooke E., Xu, Ping, Forbes, Josephine M. and Gilbert, Robert G. (2015). Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?. Current Drug Targets, 16 (10), 1088-1093. doi: 10.2174/1389450116666150727123115
Improving size-exclusion chromatography separation for glycogen
Sullivan, Mitchell A., Powell, Prudence O., Witt, Torsten, Vilaplana, Francisco, Roura, Eugeni and Gilbert, Robert G. (2014). Improving size-exclusion chromatography separation for glycogen. Journal of Chromatography A, 1332, 21-29. doi: 10.1016/j.chroma.2014.01.053
Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control
Sullivan, Mitchell A., Aroney, Samuel T. N., Li, Shihan, Warren, Frederick J., Joo, Jin Suk, Mak, Ka Sin, Stapleton, David I., Bell-Anderson, Kim S. and Gilbert, Robert G. (2014). Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control. Biomacromolecules, 15 (2), 660-665. doi: 10.1021/bm401714v
Extraction, isolation and characterisation of phytoglycogen from su-1 maize leaves and grain
Powell, Prudence O., Sullivan, Mitchell A., Sweedman, Michael C., Stapleton, David I., Hasjim, Jovin and Gilbert, Robert G. (2014). Extraction, isolation and characterisation of phytoglycogen from su-1 maize leaves and grain. Carbohydrate Polymers, 101 (1), 423-431. doi: 10.1016/j.carbpol.2013.09.061
The structure of cardiac glycogen in healthy mice
Besford, Quinn A., Sullivan, Mitchell A., Zheng, Ling, Gilbert, Robert G., Stapleton, David and Gray-Weale, Angus (2012). The structure of cardiac glycogen in healthy mice. International Journal of Biological Macromolecules, 51 (5), 887-891. doi: 10.1016/j.ijbiomac.2012.06.037
Molecular insights into glycogen alpha-particle formation
Sullivan, Mitchell A., O'Connor, Mitchell J., Umana, Felipe, Roura, Eugeni, Jack, Kevin, Stapleton, David I. and Gilbert, Robert G. (2012). Molecular insights into glycogen alpha-particle formation. Biomacromolecules, 13 (11), 3805-3813. doi: 10.1021/bm3012727
Molecular structural differences between type-2-diabetic and healthy glycogen
Sullivan, Mitchell A., Li, Jiong, Li, Chuanzhou, Vilaplana, Francisco, Stapleton, David, Gray-Weale, Angus A., Bowen, Stirling, Zheng, Ling and Gilbert, Robert G. (2011). Molecular structural differences between type-2-diabetic and healthy glycogen. Biomacromolecules, 12 (6), 1983-1986. doi: 10.1021/bm2006054
Nature of alpha and beta particles in glycogen using molecular size distributions
Sullivan, Mitchell A., Vilaplana, Francisco, Cave, Richard A., Stapleton, David, Gray-Weale, Angus A. and Gilbert, Robert G. (2010). Nature of alpha and beta particles in glycogen using molecular size distributions. Biomacromolecules, 11 (4), 1094-1100. doi: 10.1021/bm100074p
GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?
Sullivan, M. A., Wang, Z., Li, I., Milton, L., Mccarthy, D., Harcourt, B. E., Penfold, S. and Forbes, J. M. (2018). GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?. HOBOKEN: WILEY.
Glycogen: Higher -Level Molecular Structure and Diabetes
Tan, Xinle, Deng, Bin, Jiang, Xiaoyin, Zhang, Peng, Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Schulz, Benjamin L. and Gilbert, Robert G. (2016). Glycogen: Higher -Level Molecular Structure and Diabetes. 12th International Conference on Polysaccharides-Glycoscience, Prague Czech Republic, 19-21 October 2016. Prague Czech Republic: Czech Chemical Society.
The metabolic and inflammatory challenges of summer in the feedlot
Wijfells, G., Sullivan, M. L., Stockwell, S., Briscoe, S., McCulloch, R., Straube, J., Olm, J., Cawdell-Smith, J., Anderson, S. T., Le Cao, K.-A. and Gaughan, J. B. (2016). The metabolic and inflammatory challenges of summer in the feedlot. Northern Australia Beef Research Update Conference, Rockhampton, QLD Australia, 15 - 18 August 2016. Gympie, QLD, Australia: Queensland North Australia Beef Research Council.
The molecular size distribution of glycogen and its relevance to diabetes
Gilbert, Robert G. and Sullivan, Mitchell A. (2014). The molecular size distribution of glycogen and its relevance to diabetes. 34th Australasian Polymer Symposium, Darwin, Australia, 7-10 July 2013. Clayton, VIC, Australia: C S I R O Publishing. doi: 10.1071/CH13573
Vilaplana, Francisco, Sullivan, Mitchell A., Hasjim, Jovin and Gilbert, Robert G. (2011). Biosynthesis - structure - property relations for branched polysaccharides as revealed by two-dimensional macromolecular size/branch chain-length distributions. EPF 2011: European Polymer Federation Conference, Granada, Spain, 26 June-1 July 2011. European Polymer Federation; Specialized Group of Polymers (GEP); Institute of Polymer Science and Technology (ICTP-CSIC).
Liver-glycogen metabolism: A structural perspective
Sullivan, Mitchell (2014). Liver-glycogen metabolism: A structural perspective. PhD Thesis, Queensland Alliance for Agricultural and Food Innovation, The University of Queensland. doi: 10.14264/uql.2015.75
MitoKhondrion: Decreasing COVID-19 mortality by increasing the functioning of our cell's powerhouses
(2021–2024) Advance Queensland Industry Research Fellowships
Exploring the Role of Glycogen Structure in Type 2 Diabetes
(2015–2019) NHMRC Early Career Fellowships
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Doctor Philosophy — Principal Advisor
Other advisors:
Study of the structure of glycogen and potential drug target for diabetes
Doctor Philosophy — Associate Advisor
Other advisors:
The effect of high-amylose resistant starch on the glycogen structure of diabetic mice
Doctor Philosophy — Associate Advisor
Other advisors:
A new treatment for viral disease: Modulators of the renin angiotension system
Doctor Philosophy — Associate Advisor
Other advisors:
The Analysis of Liver Glycogen Structure and its Implication in Various Diseases
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Unravelling the role of glycogen in diabetic kidney disease
Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.
Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.
Aims: