Journal Article: Generation and characterization of a Ddx4‐iCre transgenic line for deletion in the germline beginning at genital ridge colonization
Burnet, Guillaume, Feng, Chun‐Wei Allen, Cheung, Ka Man Fiona, Bowles, Josephine and Spiller, Cassy M. (2023). Generation and characterization of a Ddx4‐iCre transgenic line for deletion in the germline beginning at genital ridge colonization. genesis, 61 (1-2) e23511, e23511. doi: 10.1002/dvg.23511
Book Chapter: Isolation and culture techniques for fetal mouse germ cells
Burnet, Guillaume, Bowles, Josephine and Spiller, Cassy M. (2023). Isolation and culture techniques for fetal mouse germ cells. Germline stem cells: methods and protocols. (pp. 221-231) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3259-8_13
Journal Article: Instructing mouse germ cells to adopt a female fate
Spiller, Cassy and Bowles, Josephine (2022). Instructing mouse germ cells to adopt a female fate. Sexual Development, 16 (5-6), 1-13. doi: 10.1159/000523763
Characterisation of a possible new mouse model of type II human germ cell cancer
(2023–2024) Society for Reproductive Biology
The Brain-Ovary connection: identification of a novel regulator of female reproductive function
(2023–2024) Repro Grants
(2021–2023) Silicon Valley Community Foundation
Unmasking the function of the transcription factor NFIX in mammalian gonads
Doctor Philosophy
Molecular mechanism underlying the onset of meiosis in mice
(2023) Doctor Philosophy
Investigating the role of Cripto in mouse germ cell development
(2022) Doctor Philosophy
Isolation and culture techniques for fetal mouse germ cells
Burnet, Guillaume, Bowles, Josephine and Spiller, Cassy M. (2023). Isolation and culture techniques for fetal mouse germ cells. Germline stem cells: methods and protocols. (pp. 221-231) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3259-8_13
Sexually dimorphic germ cell identity in mammals
Spiller, Cassy and Bowles, Josephine (2019). Sexually dimorphic germ cell identity in mammals. Sex determination in vertebrates. (pp. 253-288) Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ctdb.2019.01.011
Mouse fetal germ cell isolation and culture techniques
Spiller, Cassy M., Burnet, Guillaume and Bowles, Josephine (2017). Mouse fetal germ cell isolation and culture techniques. Germline stem cells. (pp. 173-183) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-4017-2_13
Cell cycle control of germ cell differentiation
Spiller, Cassy M. and Koopman, Peter (2011). Cell cycle control of germ cell differentiation. Cell cycle in development. (pp. 269-308) edited by Jacek Z. Kubiak. New York, United States: Springer. doi: 10.1007/978-3-642-19065-0
Sex Determination and Gonadal Development
Combes, Alexander, Spiller, Cassy and Koopman, Peter (2010). Sex Determination and Gonadal Development. Oogenesis: The Universal Process. (pp. 27-79) Chichester, UK: John Wiley and Sons. doi: 10.1002/9780470687970.ch2
Sex determination and Gonadal Development
Combes, Alexamder, Spiller. Cassy and Koopman, Peter (2010). Sex determination and Gonadal Development. Oogenesis : The universal process. (pp. 27-80) edited by Marie-Hélène Verlhac and Anne Villeneuve. Chichester, UK: Wiley-Blackwell.
Burnet, Guillaume, Feng, Chun‐Wei Allen, Cheung, Ka Man Fiona, Bowles, Josephine and Spiller, Cassy M. (2023). Generation and characterization of a Ddx4‐iCre transgenic line for deletion in the germline beginning at genital ridge colonization. genesis, 61 (1-2) e23511, e23511. doi: 10.1002/dvg.23511
Instructing mouse germ cells to adopt a female fate
Spiller, Cassy and Bowles, Josephine (2022). Instructing mouse germ cells to adopt a female fate. Sexual Development, 16 (5-6), 1-13. doi: 10.1159/000523763
Deletion of NFIX results in defective progression through meiosis within the mouse testis
Davila, Raul Ayala, Spiller, Cassy, Harkins, Danyon, Harvey, Tracey, Jordan, Philip W., Gronostajski, Richard M., Piper, Michael and Bowles, Josephine (2022). Deletion of NFIX results in defective progression through meiosis within the mouse testis. Biology of Reproduction, 106 (6), 1191-1205. doi: 10.1093/biolre/ioac049
Kam Draskau, Monica, Ravn Ballegaard, Anne-Sofie, Ramhøj, Louise, Bowles, Josephine, Svingen, Terje and Spiller, Cassy M. (2022). AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes. Current Research in Toxicology, 3 100069, 1-8. doi: 10.1016/j.crtox.2022.100069
Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M., Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter and Bowles, Josephine (2021). Identification of regulatory elements required for Stra8 expression, in fetal ovarian germ cells of the mouse. Development, 148 (5) dev194977, 1-13. doi: 10.1242/dev.194977
Spiller, Cassy M., Lobo, João, Boellaard, Willem P. A., Gillis, Ad J. M., Bowles, Josephine and Looijenga, Leendert H. J. (2020). CRIPTO and miR-371a-3p are serum biomarkers of testicular germ cell tumors and are detected in seminal plasma from azoospermic males. Cancers, 12 (3) 760, 760. doi: 10.3390/cancers12030760
Draskau, Monica Kam, Spiller, Cassy M., Boberg, Julie, Bowles, Josephine and Svingen, Terje (2020). Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways. Molecular Human Reproduction, 26 (2), 111-116. doi: 10.1093/molehr/gaaa001
Retinoic acid antagonizes testis development in mice
Bowles, Josephine, Feng, Chun-Wei, Ineson, Jessica, Miles, Kim, Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H. and Koopman, Peter (2018). Retinoic acid antagonizes testis development in mice. Cell Reports, 24 (5), 1330-1341. doi: 10.1016/j.celrep.2018.06.111
Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination
Zhao, Liang, Wang, Chenwei, Lehman, Melanie L., He, Mingyu, An, Jiyuan, Svingen, Terje, Spiller, Cassy M., Ng, Ee Ting, Nelson, Colleen C. and Koopman, Peter (2018). Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination. Molecular and Cellular Endocrinology, 478, 84-96. doi: 10.1016/j.mce.2018.07.010
SOX30 is required for male fertility in mice
Feng, Chun-Wei Allen, Spiller, Cassy, Merriner, Donna J., O'Bryan, Moira K., Bowles, Josephine and Koopman, Peter (2017). SOX30 is required for male fertility in mice. Scientific Reports, 7 (1) 17619, 1-12. doi: 10.1038/s41598-017-17854-5
Sex Determination in the Mammalian Germline
Spiller, Cassy, Koopman, Peter and Bowles, Josephine (2017). Sex Determination in the Mammalian Germline. Annual Review of Genetics, 51 (1), 265-285. doi: 10.1146/annurev-genet-120215-035449
Regulation of fetal male germ cell development by members of the TGFβ superfamily
Spiller, Cassy, Burnet, Guillaume and Bowles, Josephine (2017). Regulation of fetal male germ cell development by members of the TGFβ superfamily. Stem cell research, 24, 174-180. doi: 10.1016/j.scr.2017.07.016
Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis
Spiller, Cassy M. and Bowles, Josephine (2017). Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis. International Journal of Biochemistry & Cell Biology, 86, 22-25. doi: 10.1016/j.bioce1.2017.03.004
Mice lacking Hbp1 function are viable and fertile
Spiller, Cassy M., Wilhelm, Dagmar, Jans, David A., Bowles, Josephine and Koopman, Peter (2017). Mice lacking Hbp1 function are viable and fertile. PLoS One, 12 (1) e0170576, e0170576. doi: 10.1371/journal.pone.0170576
Spiller, Cassy M., Gillis, Ad J. M., Burnet, Guillaume, Stoop, Hans, Koopman, Peter, Bowles, Josephine and Looijenga, Leendert H. J. (2016). Cripto: expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. Molecular Oncology, 10 (4), 526-537. doi: 10.1016/j.molonc.2015.11.003
ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy and Koopman, Peter (2016). ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nature Communications, 7 (1) 10845, 10845.1-10845.8. doi: 10.1038/ncomms10845
Germ cells influence cord formation and leydig cell gene expression during mouse testis development
Rios-Rojas, Clarissa, Spiller, Cassy, Bowles, Josephine and Koopman, Peter (2016). Germ cells influence cord formation and leydig cell gene expression during mouse testis development. Developmental Dynamics, 245 (4), 433-444. doi: 10.1002/dvdy.24371
Sex determination in mammalian germ cells
Spiller, Cassy M. and Bowles, Josephine (2015). Sex determination in mammalian germ cells. Asian Journal of Andrology, 17 (3), 427-432. doi: 10.4103/1008-682X.150037
Regulation of germ cell meiosis in the fetal ovary
Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Regulation of germ cell meiosis in the fetal ovary. International Journal of Developmental Biology, 56 (10-12), 779-787. doi: 10.1387/ijdb.120142pk
Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. International Journal of Developmental Biology, 57 (2-4), 211-219. doi: 10.1387/ijdb.130028pk
Endogenous nodal signaling regulates germ cell potency during mammalian testis development
Spiller, Cassy M., Feng, Chun-Wei, Jackson, Andrew, Gillis, Ad J. M., Rolland, Antoine D., Looijenga, Leendert H. J., Koopman, Peter and Bowles, Josephine (2012). Endogenous nodal signaling regulates germ cell potency during mammalian testis development. Development, 139 (22), 4123-4132. doi: 10.1242/dev.083006
Identification of novel markers of mouse fetal ovary development
Chen, Huijun, Palmer, James S., Thaigarajan, Rathi D., Dinger, Marcel E., Frampton, Emmanuelle, Chiu, Hansheng, Schulz, Alexandra, Spiller, Cassy, Grimmond, Sean M., Little, Melissa H., Koopman, Peter A. and Wilhelm, Ingrid D. (2012). Identification of novel markers of mouse fetal ovary development. PLoS One, 7 (7) e41683, e41683.1-e41683.15. doi: 10.1371/journal.pone.0041683
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice
Chawengsaksophak, Kallayanee, Svingen, Terje, Ng, Ee Ting, Epp, Trevor, Spiller, Cassy M., Clark, Charlotte, Cooper, Helen and Koopman, Peter (2012). Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biology of Reproduction, 86 (1) 4, 1-12. doi: 10.1095/biolreprod.111.095232
FGF9 suppresses meiosis and promotes male germ cell fate in mice
Bowles, Josephine, Feng, Chun-Wei, Spiller, Cassy, Davidson, Tara-Lynne, Jackson, Andrew and Koopman, Peter (2010). FGF9 suppresses meiosis and promotes male germ cell fate in mice. Developmental Cell, 19 (3), 440-449. doi: 10.1016/j.devcel.2010.08.010
Spiller, Cassy M., Wilhelm, Dagmar and Koopman, Peter (2010). Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biology of Reproduction, 82 (2), 433-443. doi: 10.1095/biolreprod.109.078691
Combes, Alexander N., Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H., Dunwoodie, Sally L., Wilhelm, Dagmar and Koopman, Peter (2010). Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation. International Journal of Developmental Biology, 54 (4), 683-689. doi: 10.1387/ijdb.092920ac
Cell cycle analysis of fetal germ cells during sex differentiation in mice
Spiller, Cassy, Wilhelm, Dagmar and Koopman, Peter (2009). Cell cycle analysis of fetal germ cells during sex differentiation in mice. Biology of The Cell, 101 (10), 587-598. doi: 10.1042/BC20090021
Svingen, T, Spiller, C. M., Kashimada, K, Harley, V. R. and Koopman, P (2009). Identification of suitable normalizing genes for quantitative real-time RT-PCR analysis of gene expression in fetal mouse gonads. SEXUAL DEVELOPMENT, 3 (4), 194-204. doi: 10.1159/000228720
Nixon, Brett, Paul, Jonathan W., Spiller, Cassy M., Attwell-Heap, Abigail G., Ashman, Leonie K. and Aitken, John (2005). Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa. Journal of Cell Science, 118 (20), 4865-4877. doi: 10.1242/jcs.02604
Investigating Sex Specific Cell Cycle Regulation in Fetal Germ Cells
Cassy Spiller (2009). Investigating Sex Specific Cell Cycle Regulation in Fetal Germ Cells. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.
Characterisation of a possible new mouse model of type II human germ cell cancer
(2023–2024) Society for Reproductive Biology
The Brain-Ovary connection: identification of a novel regulator of female reproductive function
(2023–2024) Repro Grants
(2021–2023) Silicon Valley Community Foundation
How do mammalian germ cells transition from mitosis to meiosis?
(2020–2023) ARC Discovery Projects
(2020–2022) RL Cooper Medical Research Foundation Limited
Novel detection methods for adolescent germ cell cancers
(2020–2021) The Children's Hospital Foundation
Development of a non-invasive diagnostic and prognostic assay for adolescent testicular cancer
(2019–2022) The Kid's Cancer Project
Investigating spermatogonial stem cell allocation in the fetal testis
(2018–2020) ARC Discovery Projects
Molecular regulation of pluripotency in the mammalian germline
(2016–2019) NHMRC Project Grant
Isolation and characterisation of fetal gonocytes with sustained pluripotent potential
(2016–2017) UQ Early Career Researcher
Investigating new methods of treatments for chemotherapy-resistant testicular germ cell cancers
(2016) Cancer Bequest Fund
Dr Cassy Spiller - Maternity Funding (Advance Queensland Women's Academic Fund)
(2015–2016) Queensland Government Advance Queensland Women's Academic Fund
Nodal/Cripto signaling in germ cell development and tumorigenesis
(2015–2016) Cancer Council Queensland
CRIPTO as a diagnostic for testicular cancer
(2014–2019) UQ Postdoctoral Research Fellowship
Unmasking the function of the transcription factor NFIX in mammalian gonads
Doctor Philosophy — Associate Advisor
Other advisors:
Molecular mechanism underlying the onset of meiosis in mice
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Investigating the role of Cripto in mouse germ cell development
(2022) Doctor Philosophy — Associate Advisor
Other advisors: