Dr Changkui Fu is currently a UQ Development Fellow in Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ).
Dr Fu obtained his bachelor and PhD degree in Chemistry from Tsinghua University China in 2010 and 2015 respectively. After that, he moved to the Centre of Advanced Macromolecular Design (CAMD) in the UNSW as a postdoctoral researcher working with Prof Cyrille Boyer to explore photo-induced polymerization technologies. In 2016, he relocated to AIBN, UQ as a postdoctoral research Fellow in Prof Andrew Whittaker's group on developing advanced imaging agents. In 2018, He was awarded a UQ Development Fellowship to work on novel bioactive polymers.
Dr Fu's research focuses on the design and synthesis of novel polymers with well-defined molecular structures and sophisticated functionalities. These polymers are suitable for a range of advanced applications including controlled drug delivery and bioimaging. He has published a number of peer-reviewed articles in leading scientific journals including Macromolecules, ACS Macro Letter, Polymer Chemistry, Advanced Healthcare Materials, Chemical Communications, JACS, Angewandte Chemie and others, and been granted a patent. To date, these publications have received 1300 citations in total with an h-index of 21.
Zhang, Cheng, Li, Li, Han, Felicity Y., Yu, Xinying, Tan, Xiao, Fu, Changkui, Xu, Zhi Ping and Whittaker, Andrew K. (2019) Integrating fluorinated polymer and manganese‐layered double hydroxide nanoparticles as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer. Small, 15 36: 1902309. doi:10.1002/smll.201902309
Journal Article: Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer
Fu, Changkui, Tang, Joyce, Pye, Aidan, Liu, Tianqing, Zhang, Cheng, Tan, Xiao, Han, Felicity, Peng, Hui and Whittaker, Andrew K. (2019) Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer. Biomacromolecules, 20 5: 2043-2050. doi:10.1021/acs.biomac.9b00241
Journal Article: Importance of thermally induced aggregation on 19F Magnetic Resonance Imaging of perfluoropolyether-based comb-shaped poly(2-oxazoline)s
Zhang, Cheng, Sanchez, Ronny Javier Pibaque, Fu, Changkui, Clayden-Zabik, Ryan, Peng, Hui, Kempe, Kristian and Whittaker, Andrew K. (2018) Importance of thermally induced aggregation on 19F Magnetic Resonance Imaging of perfluoropolyether-based comb-shaped poly(2-oxazoline)s. Biomacromolecules, 20 1: 365-374. doi:10.1021/acs.biomac.8b01549
Novel cyclic glycopolymers for improved inhibition of bacterial AB5 toxins
(2018–2021) UQ Development Fellowships
Bringing Materials to Life
Doctor Philosophy
Novel hydrogels for delivery of cancer drugs
Doctor Philosophy
Thermoresponsive, injectable, self-healing hydrogels for drug delivery
Doctor Philosophy
Zhang, Cheng, Li, Li, Han, Felicity Y., Yu, Xinying, Tan, Xiao, Fu, Changkui, Xu, Zhi Ping and Whittaker, Andrew K. (2019) Integrating fluorinated polymer and manganese‐layered double hydroxide nanoparticles as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer. Small, 15 36: 1902309. doi:10.1002/smll.201902309
Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer
Fu, Changkui, Tang, Joyce, Pye, Aidan, Liu, Tianqing, Zhang, Cheng, Tan, Xiao, Han, Felicity, Peng, Hui and Whittaker, Andrew K. (2019) Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer. Biomacromolecules, 20 5: 2043-2050. doi:10.1021/acs.biomac.9b00241
Zhang, Cheng, Sanchez, Ronny Javier Pibaque, Fu, Changkui, Clayden-Zabik, Ryan, Peng, Hui, Kempe, Kristian and Whittaker, Andrew K. (2018) Importance of thermally induced aggregation on 19F Magnetic Resonance Imaging of perfluoropolyether-based comb-shaped poly(2-oxazoline)s. Biomacromolecules, 20 1: 365-374. doi:10.1021/acs.biomac.8b01549
Qiao, Ruirui, Esser, Lars, Fu, Changkui, Zhang, Cheng, Hu, Jinming, Ramírez-arcía, Paulina, Li, Yuhuan, Quinn, John F., Whittaker, Michael R., Whittaker, Andrew K. and Davis, Thomas P. (2018) Bioconjugation and fluorescence labeling of iron oxide nanoparticles grafted with bromomaleimide-terminal polymers. Biomacromolecules, 19 11: 4423-4429. doi:10.1021/acs.biomac.8b01282
Fu, Changkui, Zhang, Cheng, Peng, Hui, Han, Felicity, Baker, Carly, Wu, Yuao, Ta, Hang and Whittaker, Andrew K. (2018) Enhanced performance of polymeric 19F MRI contrast agents through incorporation of highly water-soluble monomer MSEA. Macromolecules, 51 15: 5875-5882. doi:10.1021/acs.macromol.8b01190
Fu, Changkui, Huang, Zixuan, Hawker, Craig J., Moad, Graeme, Xu, Jiangtao and Boyer, Cyrille (2017) RAFT-mediated, visible light-initiated single unit monomer insertion and its application in the synthesis of sequence-defined polymers. Polymer Chemistry, 8 32: 4637-4643. doi:10.1039/c7py00713b
Synthesis of discrete oligomers by sequential PET-RAFT single-unit monomer insertion
Xu, Jiangtao, Fu, Changkui, Shanmugam, Sivaprakash, Hawker, Craig J., Moad, Graeme and Boyer, Cyrille (2017) Synthesis of discrete oligomers by sequential PET-RAFT single-unit monomer insertion. Angewandte Chemie, 129 29: 8496-8503. doi:10.1002/ange.201610223
Synthesis of discrete oligomers by sequential PET-RAFT single-unit monomer insertion
Xu, Jiangtao, Fu, Changkui, Shanmugam, Sivaprakash, Hawker, Craig J., Moad, Graeme and Boyer, Cyrille (2017) Synthesis of discrete oligomers by sequential PET-RAFT single-unit monomer insertion. Angewandte Chemie International Edition, 56 29: 8376-8383. doi:10.1002/anie.201610223
Polymeric 19F MRI agents responsive to reactive oxygen species
Fu, Changkui, Herbst, Shauna, Zhang, Cheng and Whittaker, Andrew (2017) Polymeric 19F MRI agents responsive to reactive oxygen species. Polymer Chemistry, 8 31: 4585-4595. doi:10.1039/c7py00986k
Zhang, Yaling, Fu, Changkui, Li, Yongsan, Wang, Ke, Wang, Xing, Wei, Yen and Tao, Lei (2017) Synthesis of an injectable, self-healable and dual responsive hydrogel for drug delivery and 3D cell cultivation. Polymer Chemistry, 8 3: 537-544. doi:10.1039/c6py01704e
Photoacid-mediated ring opening polymerization driven by visible light
Fu, Changkui, Xu, Jiangtao and Boyer, Cyrille (2016) Photoacid-mediated ring opening polymerization driven by visible light. Chemical Communications, 52 44: 7126-7129. doi:10.1039/c6cc03084j
Fu, Changkui, Xu, Jiangtao, Kokotovic, Mitchell and Boyer, Cyrille (2016) One-pot synthesis of block copolymers by orthogonal ring-opening polymerization and PET-RAFT polymerization at ambient temperature. ACS Macro Letters, 5 4: 444-449. doi:10.1021/acsmacrolett.6b00121
Xu, Jiangtao, Shanmugam, Sivaprakash, Fu, Changkui, Aguey-Zinsou, Kondo-Francois and Boyer, Cyrille (2016) Selective photoactivation: from a single unit monomer insertion reaction to controlled polymer architectures. Journal of the American Chemical Society, 138 9: 3094-3106. doi:10.1021/jacs.5b12408
Fu, Changkui, Bongers, Andre, Wang, Ke, Yang, Bin, Zhao, Yuan, Wu, Haibo, Wei, Yen, Duong, Hien T. T., Wang, Zhiming and Tao, Lei (2016) Facile synthesis of a multifunctional copolymer via a concurrent RAFT-enzymatic system for theranostic applications. Polymer Chemistry, 7 3: 546-552. doi:10.1039/c5py01652e
Lighting up the PEGylation agents via the Hantzsch reaction
Zhang, Qingdong, Zhao, Yuan, Yang, Bin, Fu, Changkui, Zhao, Lingyun, Wang, Xing, Wei, Yen and Tao, Lei (2016) Lighting up the PEGylation agents via the Hantzsch reaction. Polymer Chemistry, 7 3: 523-528. doi:10.1039/c5py01624j
The Ugi reaction in polymer chemistry: syntheses, applications and perspectives
Yang, Bin, Zhao, Yuan, Wei, Yen, Fu, Changkui and Tao, Lei (2015) The Ugi reaction in polymer chemistry: syntheses, applications and perspectives. Polymer Chemistry, 6 48: 8233-8239. doi:10.1039/c5py01398d
Multicomponent copolycondensates via the simultaneous Hantzsch and Biginelli reactions
Wu, Haibo, Fu, Changkui, Zhao, Yuan, Yang, Bin, Wei, Yen, Wang, Zhiming and Tao, Lei (2015) Multicomponent copolycondensates via the simultaneous Hantzsch and Biginelli reactions. ACS Macro Letters, 4 11: 1189-1193. doi:10.1021/acsmacrolett.5b00637
Zhao, Yuan, Yu, Ying, Zhang, Yuanyi, Wang, Xing, Yang, Bin, Zhang, Yaling, Zhang, Qingdong, Fu, Changkui, Wei, Yen and Tao, Lei (2015) From drug to adhesive: a new application of poly(dihydropyrimidin-2(1H)-one)s via the Biginelli polycondensation. Polymer Chemistry, 6 27: 4940-4945. doi:10.1039/c5py00684h
Huang, Zengfang, Fu, Changkui, Wang, Shiqi, Yang, Bin, Wang, Xing, Zhang, Qingsong, Yuan, Jinying, Tao, Lei and Wei, Yen (2015) Optically active polymer via one-pot combination of chemoenzymatic transesterification and RAFT polymerization: synthesis and its application in hybrid silica particles. Macromolecular Chemistry and Physics, 216 13: 1483-1489. doi:10.1002/macp.201500106
Zhao, Yuan, Wu, Haibo, Zhang, Yuanyi, Wang, Xing, Yang, Bin, Zhang, Qingdong, Ren, Xu, Fu, Changkui, Wei, Yen, Wang, Zhiming, Wang, Yurong and Tao, Lei (2015) Postpolymerization modification of poly(dihydropyrimidin-2(1H)-thione)s via the thiourea-haloalkane reaction to prepare functional polymers. ACS Macro Letters, 4 8: 843-847. doi:10.1021/acsmacrolett.5b00428
Tao, Lei, Fu, Changkui and Wei, Yen (2015) New synthetic strategy for facile synthesis of functional polymers by one-pot combination of controlled radical polymerization and enzymatic reaction. Polymer International, 64 6: 705-712. doi:10.1002/pi.4875
Huang, Zengfang, Zhang, Xiqi, Zhang, Xiaoyong, Fu, Changkui, Wang, Ke, Yuan, Jinying, Tao, Lei and Wei, Yen (2015) Amphiphilic fluorescent copolymers via one-pot combination of chemoenzymatic transesterification and RAFT polymerization: synthesis, self-assembly and cell imaging. Polymer Chemistry, 6 4: 607-612. doi:10.1039/c4py01421a
Yang, Bin, Zhao, Yuan, Ren, Xu, Zhang, Xiaoyong, Fu, Changkui, Zhang, Yaling, Wei, Yen and Tao, Lei (2015) The power of one-pot: a hexa-component system containing π-π Stacking, Ugi reaction and RAFT polymerization for simple polymer conjugation on carbon nanotubes. Polymer Chemistry, 6 4: 509-513. doi:10.1039/c4py01323a
Zhang, Qingdong, Zhang, Yaling, Zhao, Yuan, Yang, Bin, Fu, Changkui, Wei, Yen and Tao, Lei (2015) Multicomponent polymerization system combining Hantzsch reaction and reversible addition - fragmentation chain transfer to efficiently synthesize well-defined poly(1,4-dihydropyridine)s. ACS Macro Letters, 4 1: 128-132. doi:10.1021/mz500734c
Zhao, Yuan, Yang, Bin, Zhang, Yaling, Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014) Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations. Polymer Chemistry, 5 23: 6656-6661. doi:10.1039/c4py00995a
Synthesis of multifunctional polymers through the ugi reaction for protein conjugation
Yang, Bin, Zhao, Yuan, Wang, Shiqi, Zhang, Yaling, Fu, Changkui, Wei, Yen and Tao, Lei (2014) Synthesis of multifunctional polymers through the ugi reaction for protein conjugation. Macromolecules, 47 16: 5607-5612. doi:10.1021/ma501385m
From polymer sequence control to protein recognition: synthesis, self-assembly and lectin binding
Lu, Jiawei, Fu, Changkui, Wang, Shiqi, Tao, Lei, Yan, Litang, Haddleton, David M., Chen, Gaojian and Wei, Yen (2014) From polymer sequence control to protein recognition: synthesis, self-assembly and lectin binding. Macromolecules, 47 14: 4676-4683. doi:10.1021/ma500664u
Fu, Changkui, Xu, Jiangtao, Tao, Lei and Boyer, Cyrille (2014) Combining enzymatic monomer transformation with photoinduced electron transfer - Reversible addition-fragmentation chain transfer for the synthesis of complex multiblock copolymers. ACS Macro Letters, 3 7: 633-638. doi:10.1021/mz500245k
Zhao, Yuan, Yang, Bin, Zhu, Chongyu, Zhang, Yaling, Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014) Introducing mercaptoacetic acid locking imine reaction into polymer chemistry as a green click reaction. Polymer Chemistry, 5 8: 2695-2699. doi:10.1039/c4py00058g
Yang, Bin, Zhao, Yuan, Fu, Changkui, Zhu, Chongyu, Zhang, Yaling, Wang, Shiqi, Wei, Yen and Tao, Lei (2014) Introducing the Ugi reaction into polymer chemistry as a green click reaction to prepare middle-functional block copolymers. Polymer Chemistry, 5 8: 2704-2708. doi:10.1039/c4py00001c
Facile one-pot synthesis of new functional polymers through multicomponent systems
Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014) Facile one-pot synthesis of new functional polymers through multicomponent systems. Macromolecular Chemistry and Physics, 215 6: 486-492. doi:10.1002/macp.201300738
Thermo and pH dual-responsive materials for controllable oil/water separation
Cao, Yingze, Liu, Na, Fu, Changkui, Li, Kan, Tao, Lei, Feng, Lin and Wei, Yen (2014) Thermo and pH dual-responsive materials for controllable oil/water separation. ACS Applied Materials and Interfaces, 6 3: 2026-2030. doi:10.1021/am405089m
Exploration of multicomponent polymerization system
Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014) Exploration of multicomponent polymerization system. Progress in Chemistry, 26 7: 1099-1106. doi:10.7536/PC140110
Fu, Changkui, Yang, Bin, Zhu, Chongyu, Wang, Shiqi, Zhang, Yun, Wei, Yen and Tao, Lei (2013) Synthesis of gradient copolymers by concurrent enzymatic monomer transformation and RAFT polymerization. Polymer Chemistry, 4 24: 5720-5725. doi:10.1039/c3py00841j
A new insight into the Biginelli reaction: the dawn of multicomponent click chemistry?
Zhu, Chongyu, Yang, Bin, Zhao, Yuan, Fu, Changkui, Tao, Lei and Wei, Yen (2013) A new insight into the Biginelli reaction: the dawn of multicomponent click chemistry?. Polymer Chemistry, 4 21: 5395-5400. doi:10.1039/c3py00553d
Nonionic polymer cross-linked chitosan hydrogel: preparation and bioevaluation
Xu, Liangxin, Zhang, Xiaoyong, Zhu, Chongyu, Zhang, Yaling, Fu, Changkui, Yang, Bin, Tao, Lei and Wei, Yen (2013) Nonionic polymer cross-linked chitosan hydrogel: preparation and bioevaluation. Journal of Biomaterials Science - Polymer Edition, 24 13: 1564-1574. doi:10.1080/09205063.2013.781934
A multicomponent polymerization system: click-chemoenzymatic-ATRP in one-pot for polymer synthesis
Zhang, Yun, Fu, Changkui, Zhu, Chongyu, Wang, Shiqi, Tao, Lei and Wei, Yen (2013) A multicomponent polymerization system: click-chemoenzymatic-ATRP in one-pot for polymer synthesis. Polymer Chemistry, 4 3: 466-469. doi:10.1039/c2py21039h
Hierarchically porous chitosan-PEG-silica biohybrid: synthesis and rapid cell adsorption
Fu, Changkui, Wang, Shiqi, Feng, Lin, Liu, Xiaoqi, Ji, Yan, Tao, Lei, Li, Shuxi and Wei, Yen (2013) Hierarchically porous chitosan-PEG-silica biohybrid: synthesis and rapid cell adsorption. Advanced Healthcare Materials, 2 2: 302-305. doi:10.1002/adhm.201200166
Fu, Changkui, Zhu, Chongyu, Wang, Shiqi, Liu, Honglei, Zhang, Yun, Guo, Hongchao, Tao, Lei and Wei, Yen (2013) One-pot synthesis of optically active polymer via concurrent cooperation of enzymatic resolution and living radical polymerization. Polymer Chemistry, 4 2: 264-267. doi:10.1039/c2py20875j
Wang, Shiqi, Fu, Changkui, Zhang, Yun, Tao, Lei, Li, Shuxi and Wei, Yen (2012) One-pot cascade synthetic strategy: a smart combination of chemoenzymatic transesterification and raft polymerization. ACS Macro Letters, 1 10: 1224-1227. doi:10.1021/mz300444w
Fu, Changkui, Tao, Lei, Zhang, Yun, Li, Shuxi and Wei, Yen (2012) Combining chemoenzymatic monomer transformation with ATRP: a facile "one-pot" approach to functional polymers. Chemical Communications, 48 72: 9062-9064. doi:10.1039/c2cc34633h
PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug
Zhang, Xiaoyong, Wang, Shiqi, Fu, Changkui, Feng, Lin, Ji, Yan, Tao, Lei, Li, Shuxi and Wei, Yen (2012) PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug. Polymer Chemistry, 3 10: 2716-2719. doi:10.1039/c2py20457f
PEGylation and polyPEGylation of nanodiamond
Zhang, Xiaoyong, Fu, Changkui, Feng, Lin, Ji, Yan, Tao, Lei, Huang, Qing, Li, Shuxi and Wei, Yen (2012) PEGylation and polyPEGylation of nanodiamond. Polymer, 53 15: 3178-3184. doi:10.1016/j.polymer.2012.05.029
CO2-responsive polymeric vesicles that breathe
Yan, Qiang, Zhou, Rong, Fu, Changkui, Zhang, Huijuan, Yin, Yingwu and Yuan, Jinying (2011) CO2-responsive polymeric vesicles that breathe. Angewandte Chemie (International Edition), 50 21: 4923-4927. doi:10.1002/anie.201100708
Electroactive conducting polymers for biomedical applications
Wei, Yen, Li, Baosong, Fu Changkui and Qi, Hongxu (2010) Electroactive conducting polymers for biomedical applications. Acta Polymerica Sinica, 12: 1399-1405. doi:10.3724/SP.J.1105.2010.10194
Immobilization of enzymes and cells in novel nanomaterials for biofuel technology
Wei, Yen, Cao, Yingze, Zhai, Wentao, Zhang, Xiang, Fu, Changkui, Tao, Lei, Feng, Lin, Yuan, Jinying and Li, Shuxi (2012). Immobilization of enzymes and cells in novel nanomaterials for biofuel technology. In: Abstracts of Papers of the American Chemical Society. 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS), San Diego Ca, (). Mar 25-29, 2012.
Novel cyclic glycopolymers for improved inhibition of bacterial AB5 toxins
(2018–2021) UQ Development Fellowships
Bringing Materials to Life
Doctor Philosophy — Associate Advisor
Other advisors:
Novel hydrogels for delivery of cancer drugs
Doctor Philosophy — Associate Advisor
Other advisors:
Thermoresponsive, injectable, self-healing hydrogels for drug delivery
Doctor Philosophy — Associate Advisor
Other advisors: