Dr Larisa Labzin

NHMRC CJ Martin Early Career Fellow

Institute for Molecular Bioscience

Overview

Qualifications

  • Doctor of Philosophy, Rheinish-Westphalian Technical University

Publications

  • Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018) Innate Immunity and Neurodegeneration. Annual Review of Medicine, 69 437-449. doi:10.1146/annurev-med-050715-104343

  • Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017) A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell, 171 7: 1692-1706.e18. doi:10.1016/j.cell.2017.10.033

  • Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016) Interferons and inflammasomes: Cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 1: 37-46. doi:10.1016/j.jaci.2016.05.010

View all Publications

Publications

Book Chapter

  • De Nardo, Dominic, Vogelhuber, Johanna, Labzin, Larisa, Langhoff, Pia and Latz, Eicke (2012). Inflammasomopathies: Diseases linked to the NLRP3 inflammasome. In New-Opathies: An Emerging Molecular Reclassification of Human Disease (pp. 23-65) : World Scientific Publishing Co.. doi:10.1142/9789814355698_0002

Journal Article

  • Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018) Innate Immunity and Neurodegeneration. Annual Review of Medicine, 69 437-449. doi:10.1146/annurev-med-050715-104343

  • Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017) A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell, 171 7: 1692-1706.e18. doi:10.1016/j.cell.2017.10.033

  • Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016) Interferons and inflammasomes: Cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 1: 37-46. doi:10.1016/j.jaci.2016.05.010

  • Zimmer, Sebastian, Grebe, Alena, Bakke, Siril S., Bode, Niklas, Halvorsen, Bente, Ulas, Thomas, Skjelland, Mona, De Nardo, Dominic, Labzin, Larisa I., Kerksiek, Anja, Hempel, Chris, Heneka, Michael T., Hawxhurst, Victoria, Fitzgerald, Michael L., Trebicka, Jonel, Björkhem, Ingemar, Gustafsson, Jan-Åke, Westerterp, Marit, Tall, Alan R., Wright, Samuel D., Espevik, Terje, Schultze, Joachim L., Nickenig, Georg, Lütjohann, Dieter and Latz, Eicke (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 333: . doi:10.1126/scitranslmed.aad6100

  • Labzin, Larisa I., Schmidt, Susanne V., Masters, Seth L., Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L., Latz, Eicke and De Nardo, Dominic (2015) ATF3 is a key regulator of macrophage IFN responses. Journal of Immunology, 195 9: 4446-4455. doi:10.4049/jimmunol.1500204

  • Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc and Schultze, Joachim L. (2014) Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research, 42 21: 13051-13060. doi:10.1093/nar/gku1078

  • Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, DeNardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas and Schultze, Joachim L. (2014) Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation. Immunity, 40 2: 274-288. doi:10.1016/j.immuni.2014.01.006

  • De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan R.G., Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L. and Latz, Eicke (2014) High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology, 15 2: 152-160. doi:10.1038/ni.2784

  • Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan and Latz, Eicke (2014) Cutting edge: The UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. Journal of Immunology, 193 7: 3257-3261. doi:10.4049/jimmunol.1301886

  • Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013) Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 35: 25362-25374. doi:10.1074/jbc.M113.496281

  • Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012) Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 16: E944-E953. doi:10.1073/pnas.1110156109

  • Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010) Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 15: 5536-5548. doi:10.1021/jm100194a

  • Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010) Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 6: 1103-1114. doi:10.1189/jlb.0509363

Grants (Administered at UQ)