The University of Queensland

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi: 10.1021/acs.bioconjchem.8b00505

Potassium channel expression and function in microglia: plasticity and possible species variations

Nguyen, Hai M., Blomster, Linda V., Christophersen, Palle and Wulff, Heike (2017). Potassium channel expression and function in microglia: plasticity and possible species variations. Channels, 11 (4), 305-315. doi: 10.1080/19336950.2017.1300738

Quantification of the functional expression of the Ca2+-activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

Blomster, Linda V., Strobaek, Dorte, Hougaard, Charlotte, Klein, Jessica, Pinborg, Lars H., Mikkelsen, Jens D. and Christophersen, Palle (2016). Quantification of the functional expression of the Ca2+-activated K+ channel KCa3.1 on microglia from adult human neocortical tissue. Glia, 64 (12), 2065-2078. doi: 10.1002/glia.23040

Retroviral glycoprotein-mediated immune suppression via the potassium channel KCa3.1 – A new strategy for amelioration of inflammatory bowel diseases

Laska, Magdalena J., Moeller, Jesper Bonnet, Graversen, Jonas Heilskov, Strøbæk, Dorte, Blomster, Linda, Christophersen, Palle and Bahrami, Shervin (2022). Retroviral glycoprotein-mediated immune suppression via the potassium channel KCa3.1 – A new strategy for amelioration of inflammatory bowel diseases. Clinical Immunology, 242 109081, 1-9. doi: 10.1016/j.clim.2022.109081

Muscle spindles of the multifidus muscle undergo structural change after intervertebral disc degeneration

James, Gregory, Stecco, Carla, Blomster, Linda, Hall, Leanne, Schmid, Annina B., Shu, Cindy C., Little, Christopher B., Melrose, James and Hodges, Paul W. (2022). Muscle spindles of the multifidus muscle undergo structural change after intervertebral disc degeneration. European Spine Journal, 31 (7), 1879-1888. doi: 10.1007/s00586-022-07235-6

Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome

Jiang, Yan, Castro, Joel, Blomster, Linda V., Agwa, Akello J., Maddern, Jessica, Schober, Gudrun, Herzig, Volker, Chow, Chun Yuen, Cardoso, Fernanda C., Demétrio De Souza França, Paula, Gonzales, Junior, Schroeder, Christina I., Esche, Steffen, Reiner, Thomas, Brierley, Stuart M. and King, Glenn F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology & Translational Science, 4 (4) acsptsci.1c00072, 1362-1378. doi: 10.1021/acsptsci.1c00072

Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs

Chow, Chun Yuen, Chin, Yanni K.-Y., Walker, Andrew A., Guo, Shaodong, Blomster, Linda V., Ward, Micaiah J., Herzig, Volker, Rokyta, Darin R. and King, Glenn F. (2019). Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs. ACS Pharmacology & Translational Science, 3 (1) acsptsci.9b00079, 119-134. doi: 10.1021/acsptsci.9b00079

Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2

Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state

Villa, Alessandro, Klein, Barbara, Janssen, Bieneke, Pedragosa, Jordi, Pepe, Giovanna, Zinnhardt, Bastian, Vugts, Danielle J., Gelosa, Paolo, Sironi, Luigi, Beaino, Wissam, Damont, Annelaure, Dollé, Frédéric, Jego, Benoit, Winkeler, Alexandra, Ory, Dieter, Solin, Olof, Vercouillie, Johnny, Funke, Uta, Laner-Plamberger, Sandra, Blomster, Linda V., Christophersen, Palle, Vegeto, Elisabetta, Aigner, Ludwig, Jacobs, Andreas, Planas, Anna M., Maggi, Adriana and Windhorst, Albert D. (2018). Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state. Theranostics, 8 (19), 5400-5418. doi: 10.7150/thno.25572

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi: 10.1021/acs.bioconjchem.8b00505

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

James, Gregory, Sluka, Kathleen A., Blomster, Linda, Hall, Leanne, Schmid, Annina B., Shu, Cindy C., Little, Christopher B., Melrose, James and Hodges, Paul W. (2018). Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury. European Spine Journal, 27 (8), 1744-1756. doi: 10.1007/s00586-018-5652-7

Potassium channel expression and function in microglia: plasticity and possible species variations

Nguyen, Hai M., Blomster, Linda V., Christophersen, Palle and Wulff, Heike (2017). Potassium channel expression and function in microglia: plasticity and possible species variations. Channels, 11 (4), 305-315. doi: 10.1080/19336950.2017.1300738

Quantification of the functional expression of the Ca2+-activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

Blomster, Linda V., Strobaek, Dorte, Hougaard, Charlotte, Klein, Jessica, Pinborg, Lars H., Mikkelsen, Jens D. and Christophersen, Palle (2016). Quantification of the functional expression of the Ca2+-activated K+ channel KCa3.1 on microglia from adult human neocortical tissue. Glia, 64 (12), 2065-2078. doi: 10.1002/glia.23040

Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes

James, Gregory, Blomster, Linda, Hall, Leanne, Schmid, Annina B., Shu, Cindy C., Little, Christopher B., Melrose, James and Hodges, Paul W. (2016). Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes. Spine, 41 (15), 1208-1217. doi: 10.1097/BRS.0000000000001669

Encenicline, an alpha 7 nicotinic acetylcholine receptor partial agonist, reduces immune cell infiltration in the colon and improves experimental colitis in mice

Salaga, M., Blomster, L. V., Piechota-Polanczyk, A., Zielinska, M., Jacenik, D., Cygankiewicz, A. I., Krajewska, W. M., Mikkelsen, J. D. and Fichna, Jakub (2016). Encenicline, an alpha 7 nicotinic acetylcholine receptor partial agonist, reduces immune cell infiltration in the colon and improves experimental colitis in mice. Journal of Pharmacology and Experimental Therapeutics, 356 (1), 157-169. doi: 10.1124/jpet.115.228205

Multifidus muscle changes after back injury are characterized by structural remodeling of muscle, adipose and connective tissue, but not muscle atrophy molecular and morphological evidence

Hodges, Paul W., James, Gregory, Blomster, Linda, Hall, Leanne, Schmid, Annina, Shu, Cindy, Little, Chris and Melrose, James (2015). Multifidus muscle changes after back injury are characterized by structural remodeling of muscle, adipose and connective tissue, but not muscle atrophy molecular and morphological evidence. Spine, 40 (14), 1057-1071. doi: 10.1097/BRS.0000000000000972

Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?

Hodges, Paul W., James, Gregory, Blomster, Linda, Hall, Leanne, Schmid, Annina B., Shu, Cindy, Little, Chris and Melrose, James (2014). Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?. Spine, 39 (13), 1010-1017. doi: 10.1097/BRS.0000000000000318

Mobilisation of the splenic monocyte reservoir and peripheral CX(3)CR1 deficiency adversely affects recovery from spinal cord injury

Blomster, Linda V., Brennan, Faith H., Lao, Hong W., Harle, David W., Harvey, Alan R. and Ruitenberg, Marc J. (2013). Mobilisation of the splenic monocyte reservoir and peripheral CX(3)CR1 deficiency adversely affects recovery from spinal cord injury. Experimental Neurology, 247, 226-240. doi: 10.1016/j.expneurol.2013.05.002

Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI

Blomster, Linda V., Cowin, Gary J., Kurniawan, Nyoman D. and Ruitenberg, Marc J. (2013). Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI. NMR in Biomedicine, 26 (2), 141-150. doi: 10.1002/nbm.2829

Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function

Rupasinghe, Darshani B., Knapp, Oliver, Blomster, Linda V., Schmid, Annina B., Adams, David J., King, Glenn F. and Ruitenberg, Marc J. (2012). Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function. Channels, 6 (2), 103-110. doi: 10.4161/chan.19484

CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium

Blomster, Linda, Vukovic, Jana, Hendrickx, Debbie A.E., Jung, Steffen, Harvey, Alan R., Filgueira, Luis and Ruitenberg, Marc J. (2011). CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Molecular and Cellular Neuroscience, 48 (3), 236-245. doi: 10.1016/j.mcn.2011.08.004

Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium

Vukovic, J, Blomster, LV, Chinnery, HR, Weninger, W, Jung, S, McMenamin, PG and Ruitenberg, MJ (2010). Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. Journal of Leukocyte Biology, 88 (4), 645-654. doi: 10.1189/jlb.0410194

CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium

Ruitenberg, Marc J., Vukovic, Jana, Blomster, Linda, Hall, Jarrad M, Jung, Steffen, Filgueira, Luis, McMenamin, Paul G. and Plant, Giles W. (2008). CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. Journal of Neuroimmunology, 205 (1-2), 80-85. doi: 10.1016/j.jneuroim.2008.09.010

Macrophage Transformation Explains Local Inflammation and Structural Change in the Multifidus Muscle after Intervertebral Disc Injury

Hodges, Paul, James, Greg P., Sluka, Kathleen A., Little, Christopher B., Hall, Leanne, Shu, Cindy C., Blomster, Linda V., Schmid, Annina and Melrose, James (2017). Macrophage Transformation Explains Local Inflammation and Structural Change in the Multifidus Muscle after Intervertebral Disc Injury. NASS Annual Meeting Proceedings, Orlando, FL, United States, 25-28 October 2017. Amsterdam, Netherlands: Elsevier . doi: 10.1016/j.spinee.2017.07.163

Multifidus muscle undergoes structural remodeling of muscle, adipose and connective tissue, but not atrophy after injury: molecular and morphological evidence

Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C. and Melrose, J. (2015). Multifidus muscle undergoes structural remodeling of muscle, adipose and connective tissue, but not atrophy after injury: molecular and morphological evidence. World Confederation for Physical Therapy Congress, Singapore, 1-4 May 2015. London, United Kingdom: Elsevier. doi: 10.1016/j.physio.2015.03.3404

Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury

Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. 11th Symposium of the International-Neurotrauma-Society, Budapest, Hungary, 19-23 March 2014. New Rochelle, NY United States: Mary Ann Liebert.

Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia

Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.