Dr Patrick Harris

NHMRC Early Career Fellow

UQ Centre for Clinical Research
Faculty of Medicine
p.harris@uq.edu.au
+61 7 334 65476

Overview

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Early Career Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, with a focus on multi-drug resistant Gram-negative bacteria.

Research Interests

  • Clinical trials
    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
  • Antibiotic resistance
    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

Research Impacts

He has published more than 50 peer-reviewed articles, many as first author, including recent publications in JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. Since 2013 has been coordinating the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122.

Other currently active research projects include:

  1. Pilot Randomised controlled trial of meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella (MERINO-2 trial). https://clinicaltrials.gov/ct2/show/NCT02437045
  2. Queensland Genomic Health Alliance (QGHA) Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. https://www.qgha.org/project-demonstration-projects/
  3. Using whole-genome sequencing to characterise carbapenem-resistant Enterobacteriaceae from QLD (the CREATE-Q Study), in collaboration with Pathology Queensland and A/Prof Scott Beatson (https://beatsonlab.com)
  4. Susceptibility of Burkholderia pseudomallei to a novel siderophore cephalosporin (cefiderocol)
  5. Assessing the effects of antibiotics on the human gut microbiome of patients admitted to the ICU (with Dr Sanmarie Schelbusch)
  6. Whole-genome sequencing of ESBL-producing E. coli and Klebsiella spp. bloodstream isolates (MERINO Trial), in collaboration with A/Prof Scott Beatson (https://beatsonlab.com)

Qualifications

  • Bachelor of Medicine/Surgery, University of London

Publications

View all Publications

Available Projects

  • The aim of this PhD is to undertake a phenotypic and genomic analysis of bacterial isolates cultured from patients enrolled in international randomised clinical trials of novel treatment strategies for patients with bloodstream infections caused by multiresistant gram-negative bacteria. A secondary aim is to explore the application of whole-genome sequencing to rapid diagnostics, infection control practice and outbreak response.

    Students will enrol through the Faculty of Medicine.

    Applicant requirements

    Either:

    Medical degree (e.g. MBBS), preferably within or having completed advanced training program related to infectious disease (e.g. FRCPA, FRACP) (or overseas equivalent)

    OR

    Science degree with an interest in microbiology, molecular biology or genomics

    *This project is available until December 2019 unless a suitable candidate is found prior.

View all Available Projects

Publications

Book Chapter

  • Peleg, A. Y. and Harris, P. (2017). Meropenem / Meropenem-vaborbactam. In Lindsay Grayson (Ed.), Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs 7th ed. (pp. 697-722) Boca Raton, Florida: Taylor & Francis.

Journal Article

Conference Publication

Other Outputs

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

Dr Patrick Harris is not currently available to take on new students.

  • The aim of this PhD is to undertake a phenotypic and genomic analysis of bacterial isolates cultured from patients enrolled in international randomised clinical trials of novel treatment strategies for patients with bloodstream infections caused by multiresistant gram-negative bacteria. A secondary aim is to explore the application of whole-genome sequencing to rapid diagnostics, infection control practice and outbreak response.

    Students will enrol through the Faculty of Medicine.

    Applicant requirements

    Either:

    Medical degree (e.g. MBBS), preferably within or having completed advanced training program related to infectious disease (e.g. FRCPA, FRACP) (or overseas equivalent)

    OR

    Science degree with an interest in microbiology, molecular biology or genomics

    *This project is available until December 2019 unless a suitable candidate is found prior.