Mr Patrick Harris

Postdoctoral Research Fellow

UQ Centre for Clinical Research
Faculty of Medicine
p.harris@uq.edu.au
+61 7 334 65476

Overview

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and Postgraduate Research Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, prior to completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, with a focus on multi-drug resistant Gram-negative bacteria.

Research Interests

  • Clinical trials
    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
  • Antibiotic resistance
    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

Research Impacts

He has published more than 45 peer-reviewed articles, many as first author, including recent publications in the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. Since 2013 has been coordinating the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. The trial completed enrolment in 2017 and aims to report in 2018.

Other currently active research projects include:

  1. Pilot Randomised controlled trial of meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella (MERINO-2 trial). https://clinicaltrials.gov/ct2/show/NCT02437045
  2. Queensland Genomic Health Alliance (QGHA) Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. https://www.qgha.org/project-demonstration-projects/
  3. Using whole-genome sequencing to characterise carbapenem-resistant Enterobacteriaceae from QLD (the CREATE-Q Study), in collaboration with Pathology Queensland and A/Prof Scott Beatson (https://beatsonlab.com)
  4. Susceptibility of Burkholderia pseudomallei to a novel siderophore cephalosporin (cefiderocol)
  5. Assessing the effects of antibiotics on the human gut microbiome of patients admitted to the ICU (with Dr Sanmarie Schelbusch)
  6. Whole-genome sequencing of ESBL-producing E. coli and Klebsiella spp. bloodstream isolates (MERINO Trial), in collaboration with A/Prof Scott Beatson (https://beatsonlab.com)

Qualifications

  • Bachelor of Medicine/Surgery, University of London

Publications

View all Publications

Publications

Book Chapter

  • Peleg, A. Y. and Harris, P. (2017). Meropenem / Meropenem-vaborbactam. In Lindsay Grayson (Ed.), Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs 7th ed. (pp. 697-722) Boca Raton, Florida: Taylor & Francis.

Journal Article

Conference Publication

Other Outputs