Mr Patrick Harris

Postdoctoral Research Fellow

UQ Centre for Clinical Research
Faculty of Medicine
p.harris@uq.edu.au
+61 7 334 65476

Overview

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and Postgraduate Research Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, prior to completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, with a focus on multi-drug resistant Gram-negative bacteria.

Research Interests

  • Clinical trials
    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
  • Antibiotic resistance
    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

Research Impacts

He has published more than 45 peer-reviewed articles, many as first author, including recent publications in the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. Since 2013 has been coordinating the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. The trial completed enrolment in 2017 and aims to report in 2018.

Other currently active research projects include:

  1. Pilot Randomised controlled trial of meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella (MERINO-2 trial). https://clinicaltrials.gov/ct2/show/NCT02437045
  2. Queensland Genomic Health Alliance (QGHA) Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. https://www.qgha.org/project-demonstration-projects/
  3. Using whole-genome sequencing to characterise carbapenem-resistant Enterobacteriaceae from QLD (the CREATE-Q Study), in collaboration with Pathology Queensland and A/Prof Scott Beatson (https://beatsonlab.com)
  4. Susceptibility of Burkholderia pseudomallei to a novel siderophore cephalosporin (cefiderocol)
  5. Assessing the effects of antibiotics on the human gut microbiome of patients admitted to the ICU (with Dr Sanmarie Schelbusch)
  6. Whole-genome sequencing of ESBL-producing E. coli and Klebsiella spp. bloodstream isolates (MERINO Trial), in collaboration with A/Prof Scott Beatson (https://beatsonlab.com)

Qualifications

  • Bachelor of Medicine/Surgery, University of London

Publications

  • Scott, Susan, Harris, Patrick N., Williamson, Deborah A., Liss, Michael A., Doi, Suhail A. R. and Roberts, Matthew J. (2018) The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis. World Journal of Urology, . doi:10.1007/s00345-018-2217-7

  • Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018) Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 2: . doi:10.1128/AAC.02280-17

  • Pang, Long, Harris, Patrick N. A., Seiler, Rachel L., Ooi, Peng Lim, Cutter, Jeffrey, Goh, Kee Tai, Cook, Alex R., Fisher, Dale and Chai, Louis Yi Ann (2018) Melioidosis, Singapore, 2003–2014. Emerging Infectious Diseases, 24 1: 140-143. doi:10.3201/eid2401.161449

View all Publications

Publications

Book Chapter

  • Peleg, A. Y. and Harris, P. (2017). Meropenem / Meropenem-vaborbactam. In Lindsay Grayson (Ed.), Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs 7th ed. (pp. 697-722) Boca Raton, Florida: Taylor & Francis.

Journal Article

Conference Publication

Other Outputs