The University of Queensland

The plant defensin Ppdef1 is a novel topical treatment for onychomycosis

van der Weerden, Nicole L., Parisi, Kathy, McKenna, James A., Hayes, Brigitte M., Harvey, Peta J., Quimbar, Pedro, Wevrett, Sean R., Veneer, Prem K., McCorkelle, Owen, Vasa, Shaily, Guarino, Rosemary, Poon, Simon, Gaspar, Yolanda M., Baker, Michael J., Craik, David J., Turner, Rob B., Brown, Marc B., Bleackley, Mark R. and Anderson, Marilyn A. (2023). The plant defensin Ppdef1 is a novel topical treatment for onychomycosis. Journal of Fungi, 9 (11) 1111, 1-16. doi: 10.3390/jof9111111

Structure–activity relationships of alanine scan mutants αO-conotoxins GeXIVA[1,2] and GeXIVA[1,4]

Xu, Pan, Zhang, Panpan, Zhu, Xiaopeng, Wu, Yong, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2023). Structure–activity relationships of alanine scan mutants αO-conotoxins GeXIVA[1,2] and GeXIVA[1,4]. Journal of Medicinal Chemistry, 66 (14), 10092-10107. doi: 10.1021/acs.jmedchem.3c01023

Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii

Regalado, Laura, Sario, Sara, Mendes, Rafael J., Valle, Javier, Harvey, Peta J., Teixeira, Cátia, Gomes, Paula, Andreu, David and Santos, Conceição (2023). Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii. Insects, 14 (6) 533, 1-15. doi: 10.3390/insects14060533

A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29). doi: 10.1002/ange.202302812

A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812

Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7

Zhao, Zitong, Pan, Teng, Chen, Shen, Harvey, Peta J., Zhang, Jinghui, Li, Xiao, Yang, Mengke, Huang, Linhong, Wang, Shoushi, Craik, David J., Jiang, Tao and Yu, Rilei (2023). Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7. Journal of Biological Chemistry, 299 (4) 103068, 1-12. doi: 10.1016/j.jbc.2023.103068

Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis

Jackson, Mark A., Xie, Jing, Nguyen, Linh T. T., Wang, Xiaohan, Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2023). Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. Transgenic Research, 32 (1-2), 121-133. doi: 10.1007/s11248-023-00341-1

Designing antimicrobial peptides using deep learning and molecular dynamic simulations

Cao, Qiushi, Ge, Cheng, Wang, Xuejie, Harvey, Peta J., Zhang, Zixuan, Ma, Yuan, Wang, Xianghong, Jia, Xinying, Mobli, Mehdi, Craik, David J., Jiang, Tao, Yang, Jinbo, Wei, Zhiqiang, Wang, Yan, Chang, Shan and Yu, Rilei (2023). Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics, 24 (2) bbad058, 1-13. doi: 10.1093/bib/bbad058

Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors

Zhu, Xiaopeng, Wang, Shuai, Kaas, Quentin, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2023). Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 66 (3), 2020-2031. doi: 10.1021/acs.jmedchem.2c01786

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148

Modified horseshoe crab peptides target and kill bacteria inside host cells

Amiss, Anna S., von Pein, Jessica B., Webb, Jessica R., Condon, Nicholas D., Harvey, Peta J., Phan, Minh-Duy, Schembri, Mark A., Currie, Bart J., Sweet, Matthew J., Craik, David J., Kapetanovic, Ronan, Henriques, Sónia Troeira and Lawrence, Nicole (2021). Modified horseshoe crab peptides target and kill bacteria inside host cells. Cellular and Molecular Life Sciences, 79 (1) 38, 38. doi: 10.1007/s00018-021-04041-z

Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotides

Hellinger, Roland, Muratspahić, Edin, Devi, Seema, Koehbach, Johannes, Vasileva, Mina, Harvey, Peta J., Craik, David J., Gründemann, Carsten and Gruber, Christian W. (2021). Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotides. ACS Chemical Biology, 16 (11) acschembio.1c00524, 2373-2386. doi: 10.1021/acschembio.1c00524

Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors

Wang, Shuai, Zhu, Xiaopeng, Zhangsun, Manqi, Wu, Yong, Yu, Jinpeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2021). Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 64 (9), 5620-5631. doi: 10.1021/acs.jmedchem.0c02079

Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus

Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716

In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensis

Dang, Tien T., Chan, Lai Y., Tombling, Benjamin J., Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2021). In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensis. Journal of Natural Products, 84 (2), 395-407. doi: 10.1021/acs.jnatprod.0c01065

Cyclotide structures revealed by NMR, with a little help from X-ray crystallography

Handley, Thomas N. G., Harvey, Peta J., Wang, Conan K., Lawrence, Nicole and Craik, David (2020). Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem, 21 (24) cbic.202000315, 3463-3475. doi: 10.1002/cbic.202000315

Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)

Handley, Thomas N. G., Wang, Conan K., Harvey, Peta J., Lawrence, Nicole and Craik, David J. (2020). Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020). ChemBioChem, 21 (24), 3449-3449. doi: 10.1002/cbic.202000778

Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme

Qu, Haiou, Jackson, Mark A., Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2020). Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme. Planta, 252 (6) 97, 97. doi: 10.1007/s00425-020-03505-z

Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors

Huynh, Peter N., Harvey, Peta J., Gajewiak, Joanna, Craik, David J. and Michael McIntosh, J. (2020). Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochemical Pharmacology, 181 114124, 114124. doi: 10.1016/j.bcp.2020.114124

Neurotoxic peptides from the venom of the giant Australian stinging tree

Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828

Synthesis, structure, and activity of the antifungal plant defensin PvD1

Skalska, Julia, Andrade, Vitor M., Cena, Gabrielle L., Harvey, Peta J., Gaspar, Diana, Mello, Érica O., Henriques, Sónia T., Valle, Javier, Gomes, Valdirene M., Conceição, Katia, Castanho, Miguel A. R. B. and Andreu, David (2020). Synthesis, structure, and activity of the antifungal plant defensin PvD1. Journal of Medicinal Chemistry, 63 (17) acs.jmedchem.0c00543, 9391-9402. doi: 10.1021/acs.jmedchem.0c00543

Histidine-rich defensins from the Solanaceae and Brasicaceae are antifungal and metal binding proteins

Bleackley, Mark R., Vasa, Shaily, Harvey, Peta J., Shafee, Thomas M. A., Kerenga, Bomai K., Soares da Costa, Tatiana P., Craik, David J., Lowe, Rohan G. T. and Anderson, Marilyn A. (2020). Histidine-rich defensins from the Solanaceae and Brasicaceae are antifungal and metal binding proteins. Journal of Fungi, 6 (3) 145, 145-14. doi: 10.3390/jof6030145

Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020). Angewandte Chemie, 132 (28), 11258-11258. doi: 10.1002/ange.202006713

Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020). Angewandte Chemie International Edition, 59 (28), 11162-11162. doi: 10.1002/anie.202006713

Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, 132 (28) anie.202003435, 11369-11373. doi: 10.1002/anie.202003435

Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway

Yu, Rilei, Wang, Jiayi, So, Lok-Yan, Harvey, Peta J., Shi, Juan, Liang, Jiazhen, Dou, Qin, Li, Xiao, Yan, Xiayi, Huang, Yen-Hua, Xu, Qingliang, Kaas, Quentin, Chow, Ho-Yin, Wong, Kwok-Yin, Craik, David J, Zhang, Xiaohua, Jiang, Tao and Wang, Yan (2020). Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway. Journal of Medicinal Chemistry, 63 (7), 3475-3484. doi: 10.1021/acs.jmedchem.9b01563

Structure and activity studies of disulfide-deficient analogues of αO-conotoxin GeXIVA

Xu, Pan, Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Li, Xincan, Harvey, Peta J., Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2020). Structure and activity studies of disulfide-deficient analogues of αO-conotoxin GeXIVA. Journal of Medicinal Chemistry, 63 (4), 1564-1575. doi: 10.1021/acs.jmedchem.9b01409

Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells

Lawrence, Nicole, Philippe, Grégoire J.-B., Harvey, Peta J., Condon, Nicholas D., Benfield, Aurélie H., Cheneval, Olivier, Craik, David J. and Troeira Henriques, Sónia (2020). Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells. RSC Chemical Biology, 1 (5), 405-420. doi: 10.1039/d0cb00099j

Synthesis and biological activity study of the retro-isomer of RhTx against TRPV1

Yu, Rilei, Liu, Huijie, Wang, Baishi, Harvey, Peta J., Wei, Ningning and Chu, Yanyan (2020). Synthesis and biological activity study of the retro-isomer of RhTx against TRPV1. RSC Advances, 10 (4), 2141-2145. doi: 10.1039/c9ra08829f

The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins

Bleackley, Mark R., Dawson, Charlotte S., Payne, Jennifer A.E., Harvey, Peta J., Rosengren, K. Johan, Quimbar, Pedro, Garcia-Ceron, Donovan, Lowe, Rohan, Bulone, Vincent, van der Weerden, Nicole L, Craik, David J. and Anderson, Marilyn A. (2019). The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. The Cell Surface, 5 100026, 100026. doi: 10.1016/j.tcsw.2019.100026

In Silico design of MDM2-targeting peptides from a naturally occurring constrained peptide

Ma, He, Qiu, Peiju, Harvey, Peta J., Li, Xiao, Zhang, Zheyu, Xu, Qingliang, Liang, Jiazhen, Kaas, Quentin, Craik, David J., Yang, Jinbo, Jiang, Tao, Bi, Xiaolin and Yu, Rilei (2019). In Silico design of MDM2-targeting peptides from a naturally occurring constrained peptide. Chemmedchem, 14 (19) cmdc.201900366, 1710-1716. doi: 10.1002/cmdc.201900366

Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties

Vernen, Felicitas, Harvey, Peta J., Dias, Susana A., Veiga, Ana Salomé, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties. International Journal of Molecular Sciences, 20 (17) 4184, 4184. doi: 10.3390/ijms20174184

Salt-tolerant antifungal and antibacterial activities of the corn defensin ZmD32

Kerenga, Bomai K., McKenna, James A., Harvey, Peta J., Quimbar, Pedro, Garcia-Ceron, Donovan, Lay, Fung T., Thanh Kha Phan,, Veneer, Prem K., Vasa, Shaily, Parisi, Kathy, Shafee, Thomas M. A., van der Weerden, Nicole L., Hulett, Mark D., Craik, David J., Anderson, Marilyn A. and Bleackley, Mark R. (2019). Salt-tolerant antifungal and antibacterial activities of the corn defensin ZmD32. Frontiers in Microbiology, 10 795, 795. doi: 10.3389/fmicb.2019.00795

A centipede toxin family defines an ancient class of CSαβ defensins

Dash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019). A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 (2), 315-326. doi: 10.1016/j.str.2018.10.022

Discovery and characterization of cyclotides from Rinorea species

Niyomploy, Ploypat, Chan, Lai Yue, Harvey, Peta J., Poth, Aaron G., Colgrave, Michelle L. and Craik, David J. (2018). Discovery and characterization of cyclotides from Rinorea species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00572, 2512-2520. doi: 10.1021/acs.jnatprod.8b00572

Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist

Yu, Jinpeng, Zhu, Xiaopeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2018). Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist. Journal of Medicinal Chemistry, 61 (20), 9256-9265. doi: 10.1021/acs.jmedchem.8b00967

NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency

Harvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas and Craik, David J. (2018). NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency. Molecules, 23 (10) molecules23102715, 2715. doi: 10.3390/molecules23102715

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

Hone, Arik J., Talley, Todd T, Bobango, Janet, Huidobro Melo, Cesar, Hararah, Fuaad, Gajewiak, Joanna B., Christensen, Sean B, Harvey, Peta J., Craik, David J. and McIntosh, J. Michael (2018). Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 293 (46), 17838-17852. doi: 10.1074/jbc.ra118.005649

Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption

Lawrence, Nicole, Dennis, Adelaide S. M., Lehane, Adele M., Ehmann, Anna, Harvey, Peta J., Benfield, Aurélie H., Cheneval, Olivier, Henriques, Sónia Troeira, Craik, David J. and McMorran, Brendan J. (2018). Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chemical Biology, 25 (9), 1140-+. doi: 10.1016/j.chembiol.2018.06.009

Calcium-mediated allostery of the EGF fold

Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018). Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 (6), 1659-1667. doi: 10.1021/acschembio.8b00291

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018). Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 (8), 3674-3684. doi: 10.1021/acs.jmedchem.8b00170

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin

Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018). Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 (8), 2261-2276. doi: 10.1021/acs.jpcb.7b12419

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors

Wu, Yong, Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Zhangsun, Manqi, Harvey, Peta J., Craik, David J., McIntosh, J. Michael and Luo, Sulan (2017). α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry, 60 (13), 5826-5833. doi: 10.1021/acs.jmedchem.7b00546

Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells

Verbandt, Sara, Henriques, Sónia Troeira, Spincemaille, Pieter, Harvey, Peta J., Chandhok, Gursimran, Sauer, Vanessa, De Coninck, Barbara, Cassiman, David, Craik, David J., Cammue, Bruno P. A., De Cremer, Kaat and Thevissen, Karin (2017). Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development, 161 (B), 247-254. doi: 10.1016/j.mad.2016.07.013

Accurate de novo design of hyperstable constrained peptides

Bhardwaj, Gaurav, Mulligan, Vikram Khipple, Bahl, Christopher D., Gilmore, Jason M., Harvey, Peta J., Cheneval, Olivier, Buchko, Garry W., Pulavarti, Surya V. S. R. K., Kaas, Quentin, Eletsky, Alexander, Huang, Po-Ssu, Johnsen, William A., Greisen, Per Jr, Rocklin, Gabriel J., Song, Yifan, Linsky, Thomas W., Watkins, Andrew, Rettie, Stephen A., Xu, Xianzhong, Carter, Lauren P., Bonneau, Richard, Olson, James M., Coutsias, Evangelos, Correnti, Colin E., Szyperski, Thomas, Craik, David J. and Baker, David (2016). Accurate de novo design of hyperstable constrained peptides. Nature, 538 (7625), 329-335. doi: 10.1038/nature19791

The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

Vriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Braem, Annabel, Vleugels, Jozef, Coninck, Barbara De, Cammue, Bruno P. A. and Thevissen, Karin (2016). The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides, 75, 71-79. doi: 10.1016/j.peptides.2015.11.001

Synergistic activity of the plant defensin HsAFP1 and caspofungin against Candida albicans biofilms and planktonic cultures

Vriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Spincemaille, Pieter, Cassiman, David, Braem, Annabel, Vleugels, Jozef, Nibbering, Peter H., Drijfhout, Jan Wouter, De Coninck, Barbara, Cammue, Bruno P. A. and Thevissen, Karin (2015). Synergistic activity of the plant defensin HsAFP1 and caspofungin against Candida albicans biofilms and planktonic cultures. PLoS ONE, 10 (8) e0132701, 1-22. doi: 10.1371/journal.pone.0132701

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor. I., Christensen, Sean, Romero, Haylie K., McIntrye, Melissa, Dowell, Cheryl, Baxter, James, C., Elmslie, Keith S., Craik, David J. and McIntosh, Michael (2015). Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 (30), e4026-e4035. doi: 10.1073/pnas.1503617112

The effect of solvent polarity on the rate of the Mitsunobu esterification reaction

Camp, David, Harvey, Peta J. and Jenkins, Ian d. (2015). The effect of solvent polarity on the rate of the Mitsunobu esterification reaction. Tetrahedron, 71 (23), 3932-3938. doi: 10.1016/j.tet.2015.04.035

Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic

Gori, Alessandro, Wang, Ching-I A., Harvey, Peta J., Rosengren, K. Johan, Bhola, Rebecca F., Gelmi, Maria L., Longhi, Renato, Christie, Macdonald J., Lewis, Richard J., Alewood, Paul F. and Brust, Andreas (2015). Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic. Angewandte Chemie - International Edition, 54 (4), 1361-1364. doi: 10.1002/anie.201409678

Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR

Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014). Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 (38), 11129-11136. doi: 10.1021/jp506678f

The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013)

Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013). Biopolymers, 102 (1), 136-136. doi: 10.1002/bip.22443

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52), 21183-21188. doi: 10.1073/pnas.1311183110

Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3/beta4 nicotinic acetylcholine receptors

Luo, Sulan, Zhangsun, Dongting, Zhu, Xiaopeng, Wu, Yong, Hu, Yuanyan, Christensen, Sean, Harvey, Peta J., Akcan, Muharrem, Craik, David J. and McIntosh, Michael (2013). Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3/beta4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, Article ASAP (13), A-I. doi: 10.1021/jm401254c

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions

Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions. Peptide Science, Accepted Article (5), 1-16. doi: 10.1002/bip.22269

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold

Gao, Bin, Harvey, Peta J., Craik, David J., Ronjat, Michel, De Waard, Michel and Zhu, Shunyi (2013). Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold. Bioscience Reports, 33 (3) e00047, e00047.1-e00047.15. doi: 10.1042/BSR20130052

Structural characterization of the cyclic cystine ladder motif of θ-defensins

Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a

Dermatophytic defensin with antiinfective potential

Zhu, Shunyi, Gao, Bin, Harvey, Peta J. and Craik, David J. (2012). Dermatophytic defensin with antiinfective potential. Proceedings of the National Academy of Sciences of the United States of America, 109 (22), 8495-8500. doi: 10.1073/pnas.1201263109

Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38)

Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2012). Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38). Current Pharmaceutical Design, 18 (8) doi: 10.2174/138161212799315858

Engineering of conotoxins for the treatment of pain

Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2011). Engineering of conotoxins for the treatment of pain. Current Pharmaceutical Design, 17 (38), 4242-4253. doi: 10.2174/138161211798999401

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19), 4077-4086. doi: 10.1021/bi2004153

Chronic disease and infant nutrition: Is it significant to public health?

Smith, Julie P. and Harvey, Peta J. (2011). Chronic disease and infant nutrition: Is it significant to public health?. Public Health Nutrition, 14 (2), 279-289. doi: 10.1017/S1368980010001953

Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling

Kimura, Takashi, Lueck, John D., Harvey, Peta J., Pace, Suzy M., Ikemoto, Noriaki, Casarotto, Marco G., Kirksen, Robert T. and Dulhunty, Angela F. (2009). Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. Cell Calcium, 45 (3), 264-274. doi: 10.1016/j.ceca.2008.11.005

Malignant hyperthermia mutation sites in the Leu2442–Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area

Bannister, Mark L., Hamada, Tomoyo, Murayama, Takashi, Harvey, Peta J., Casarotto, Marco G., Dulhunty, Angela F. and Ikemoto, Noriaki (2007). Malignant hyperthermia mutation sites in the Leu2442–Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochemical Journal, 401 (1), 333-339. doi: 10.1042/BJ20060902

Structural and functional characterization of interactions between the dihydropyrdine receptor II-III loop and the ryanodine receptor

Casarotto, Marco G., Cui, Yanfang, Karunasekara, Yamuna, Harvey, Peta J., Norris, Nicole, Board, Philip G. and Dulhunty, Angela F. (2006). Structural and functional characterization of interactions between the dihydropyrdine receptor II-III loop and the ryanodine receptor. Clinical and Experimental Pharmacology and Physiology, 33 (11), 1114-1117. doi: 10.1111/j.1440-1681.2006.04501.x

Effects of an α-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer

Pouliquin, Pierre, Pace, Suzy M., Curtis, Suzanne M., Harvey, Peta J., Gallant, Esther M., Zorzato, Francesco, Casarotto, Marco G. and Dulhunty, Angela F. (2006). Effects of an α-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer. The International Journal of Biochemistry & Cell Biology, 38 (10), 1700-1715. doi: 10.1016/j.biocel.2006.03.020

Letter to the Editor: 1H, 13C and 15N assignments for the II–III loop region of the skeletal dyhydropyridine receptor

Cui, Yanfang, Karunasekara, Yamuna, Harvey, Peta J., Board, Philip G., Dulhunty, Angela F. and Casarotto, Marco G. (2005). Letter to the Editor: 1H, 13C and 15N assignments for the II–III loop region of the skeletal dyhydropyridine receptor. Journal of Biomolecular NMR, 32 (1), 89-90. doi: 10.1007/s10858-005-3038-8

Role of some unconserved residues in the "C" region of the skeletal DHPR II-III loop

Dulhunty, Angela F., Karunasekara, Yamuna, Curtis, Suzanne M., Harvey, Peta J., Board, Philip G. and Casarotto, Marco G. (2005). Role of some unconserved residues in the "C" region of the skeletal DHPR II-III loop. Frontiers in Bioscience, 10 (10), 1368-1381. doi: 10.2741/1626

Functional implications of modifying RyR‐activating peptides for membrane permeability

Dulhunty, Angela F., Cengia, Louise, Young, Jacqui, Pace, Suzy M., Harvey, Peta J., Lamb, Graham D., Chan, Yiu-Ngok, Wimmer, Norbert, Toth, Istvan and Casarotto, Marco G. (2005). Functional implications of modifying RyR‐activating peptides for membrane permeability. British Journal of Pharmacology, 144 (6), 743-754. doi: 10.1038/sj.bjp.0705981

The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity

Dulhunty, Angela F., Karunasekara, Yamuna, Curtis, Suzanne M., Harvey, Peta J., Board, Philip G. and Casarotto, Marco G. (2005). The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity. Biochemical Journal, 385 (Part 3), 803-813. doi: 10.1042/BJ20041152

31P MAS-NMR of human erythrocytes: Independence of cell volume from angular velocity

Kuchel, P.W., Bubb, W.A., Ramadan, S., Chapman, B.E., Philp, D.J., Coen, M., Gready, J.E., Harvey, P.J., McLean, A.J. and Hook, J. (2004). 31P MAS-NMR of human erythrocytes: Independence of cell volume from angular velocity. Magnetic Resonance in Medicine, 52 (3), 663-668. doi: 10.1002/mrm.20139

Hepatic phospholipid changes induced by sustained oxygen supplementation

Harvey, PJ, Gready, JE, Yin, ZL, Le Couteur, DG and McLean, AJ (2002). Hepatic phospholipid changes induced by sustained oxygen supplementation. Pharmacology & Toxicology, 91 (3), 150-152. doi: 10.1034/j.1600-0773.2002.910310.x

Pseudocapillarization and associated energy limitation in the aged rat liver

Le Couteur, DG, Cogger, VC, Markus, AMA, Harvey, PJ, Yin, ZL, Ansselin, AD and McLean, AJ (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33 (3), 537-543. doi: 10.1053/jhep.2001.22754

Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats

Harvey, PJ, Gready, JE, Yin, ZL, Le Couteur, DG and McLean, AJ (2000). Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats. Journal of Pharmacology and Experimental Therapeutics, 293 (2), 641-645.

Oxidative injury reproduces age-related impairment of oxygen-dependent drug metabolism

Le Couteur, DG, Hickey, HM, Harvey, PJ and McLean, AJ (1999). Oxidative injury reproduces age-related impairment of oxygen-dependent drug metabolism. Pharmacology & Toxicology, 85 (5), 230-232.

Hepatic oxygen supplementation as therapy in cirrhotic liver disease

Harvey, PJ, LeCouteur, D and McLean, AJ (1999). Hepatic oxygen supplementation as therapy in cirrhotic liver disease. Gastroenterology, 117 (4), 1025-1026. doi: 10.1016/S0016-5085(99)70370-7

Hepatic artery flow and propranolol metabolism in perfused cirrhotic rat liver

Le Couteur, DG, Hickey, H, Harvey, PJ, Gready, J and McLean, AJ (1999). Hepatic artery flow and propranolol metabolism in perfused cirrhotic rat liver. Journal of Pharmacology and Experimental Therapeutics, 289 (3), 1553-1558.

31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats

Harvey, Peta J., Gready, Jill E., Hickey, Haruyo M., Le Couteur, David G. and McLean, Allan J. (1999). 31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats. NMR in Biomedicine, 12 (6), 395-401. doi: 10.1002/(SICI)1099-1492(199910)12:6<395::AID-NBM568>3.0.CO;2-M

Silver(I) nitrate adducts with bidentate 2-, 3- and 4-pyridyl phosphines. Solution P-31 and [P-31-Ag-109] NMR studies of 1 : 2 complexes and crystal structure of dimeric [{Ag(d2pype)(mu-d2pype)}(2)]-[NO3](2)center dot 2CH(2)Cl(2) [d2pype = 1,2-bis(di-2-pyridylphosphino)ethane]

Berners-Price, SJ, Bowen, RJ, Harvey, PJ, Healy, PC and Koutsantonis, GA (1998). Silver(I) nitrate adducts with bidentate 2-, 3- and 4-pyridyl phosphines. Solution P-31 and [P-31-Ag-109] NMR studies of 1 : 2 complexes and crystal structure of dimeric [{Ag(d2pype)(mu-d2pype)}(2)]-[NO3](2)center dot 2CH(2)Cl(2) [d2pype = 1,2-bis(di-2-pyridylphosphino)ethane]. Journal of the Chemical Society-Dalton Transactions (11), 1743-1750.

Influence of anion on the solution and solid-state structures of some 1:2 adducts of silver(I) salts with 1,3-bis(diphenylphosphino)propane

Affandi, Dermawan, Berners-Price, Susan J., Effendy, , Harvey, Peta J., Healy, Peter C., Ruch, Beate E. and White, Allan H. (1997). Influence of anion on the solution and solid-state structures of some 1:2 adducts of silver(I) salts with 1,3-bis(diphenylphosphino)propane. Journal of the Chemical Society - Dalton Transactions (8), 1411-1420. doi: 10.1039/a607692k

Solvent-mediated allylation of carbonyl compounds with allylic stannanes

Cokley, TM, Harvey, PJ, Marshall, RL, McCluskey, A and Young, DJ (1997). Solvent-mediated allylation of carbonyl compounds with allylic stannanes. Journal of Organic Chemistry, 62 (7), 1961-1964. doi: 10.1021/jo962332l

The formation of anhydrides in the Mitsunobu reaction

Harvey, PJ, vonItzstein, M and Jenkins, ID (1997). The formation of anhydrides in the Mitsunobu reaction. Tetrahedron, 53 (11), 3933-3942. doi: 10.1016/S0040-4020(97)00010-0

Spectroscopic and structural studies on 1:1 adducts of silver(I) salts with tricyclohexylphosphine

Bowmaker, GA, , , Harvey, PJ, Healy, PC, Skelton, BW and White, AH (1996). Spectroscopic and structural studies on 1:1 adducts of silver(I) salts with tricyclohexylphosphine. Journal of the Chemical Society-Dalton Transactions (12), 2459-2465. doi: 10.1039/dt9960002459

Spectroscopic and structural studies on 1:2 adducts of silver(I) salts with tricyclohexylphosphine

Bowmaker, GA, , , Harvey, PJ, Healy, PC, Skelton, BW and White, AH (1996). Spectroscopic and structural studies on 1:2 adducts of silver(I) salts with tricyclohexylphosphine. Journal of the Chemical Society-Dalton Transactions (12), 2449-2457. doi: 10.1039/dt9960002449

Phosphitylation via the Mitsunobu reaction

Grice, ID, Harvey, PJ, Jenkins, ID, Gallagher, MJ and Ranasinghe, MG (1996). Phosphitylation via the Mitsunobu reaction. Tetrahedron Letters, 37 (7), 1087-1090. doi: 10.1016/0040-4039(95)02282-1

SYNTHESIS OF FLUOROPHOSPHORANES VIA THE MITSUNOBU REACTION

HARVEY, PJ and JENKINS, ID (1994). SYNTHESIS OF FLUOROPHOSPHORANES VIA THE MITSUNOBU REACTION. Tetrahedron Letters, 35 (52), 9775-9778. doi: 10.1016/0040-4039(94)88383-1

ACETYLENE-SENSITIZED IRRADIATION CROSS-LINKING OF POLYETHYLENE - A MODEL-COMPOUND STUDY BY C-13-NMR

ALBERT, CF, BUSFIELD, WK and HARVEY, P (1994). ACETYLENE-SENSITIZED IRRADIATION CROSS-LINKING OF POLYETHYLENE - A MODEL-COMPOUND STUDY BY C-13-NMR. Journal of Polymer Science Part A-Polymer Chemistry, 32 (16), 3197-3200. doi: 10.1002/pola.1994.080321622

Structural, Far-IR, and Solid State 31P NMR Studies of Two-Coordinate Complexes of Tris(2,4,6-trimethoxyphenyl)phosphine with Copper(I) Iodide

Baker, Lisa-Jane, Bowmaker, Graham A., Hart, Robert D., Harvey, Peta J., Healy, Peter C. and White, Allan H. (1994). Structural, Far-IR, and Solid State 31P NMR Studies of Two-Coordinate Complexes of Tris(2,4,6-trimethoxyphenyl)phosphine with Copper(I) Iodide. Inorganic Chemistry, 33 (18), 3925-3931. doi: 10.1021/ic00096a016

SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID

Brust, A., Gori, A., Wang, C-I A., Harvey, P. J., Rosengren, K. J., Gelmi, M. L., Longh, R., Lewis, R. J. and Alewood, P. F. (2014). SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID. 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August – 5 September 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687