He is a Research Fellow with the Microbial Biology and Metagenomics group within the Immunology Program of the University of Queensland Frazer Institute and an honorary fellowship with The Commonwealth Scientific and Industrial Research Organisation (CSIRO, 2019-2021). His PhD research involved designing and applying DNA transfer systems for heterologous protein expression in Lactobacillus spp. He moved to The Ohio State University, USA to conduct postdoctoral research in gut microbiology, focusing on fibre-degrading bacteria and their production of multi-protein complexes supporting this process. He was recruited to join CSIRO (Brisbane) to undertake collaborative research projects for the “Colorectal Cancer and Gut Health” Theme of their Preventative Health Flagship Research Program. His contributions during this time were to develop further and use the DNA microarray technology he had pioneered to examine the stool and mucosa-associated microbiota communities in Crohn’s disease with French and Australian collaborators. These efforts led to several highly cited and high-impact publications in key medical journals, recognised for providing some of the first insights into the critical bacterial taxa that underpin the microbial “dysbiosis” now considered a hallmark of Crohn’s disease. In early 2019, he accepted a position with professor Morrison’s group as part of my ongoing collaborations with Melbourne University in Crohn’s disease research supported via the Helmsley Charitable Trust. He is providing leadership in using a novel ex-vivo combination of gut microbe culture and metagenomic sequencing for the first deep functional characterisation of the Crohn’s disease mucosa-associated microbiota. His development and implementation of innovative molecular biology and “omics” approach help better understand complex microbial gut systems relevant to human health.
Journal Article: - Invited Review - Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota
Leong, Lex E X, Denman, Stuart E, Kang, Seungha, Mondot, Stanislas, Hugenholtz, Philip and McSweeney, Chris S (2023). - Invited Review - Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota. Animal bioscience, 37 (2), 396-403. doi: 10.5713/ab.23.0351
Journal Article: Effects of different feeding systems on ruminal fermentation, digestibility, methane emissions, and microbiota of Hanwoo steers
Lee, Seul, Kim, Jungeun, Baek, Youlchang, Seong, Pilnam, Song, Jaeyong, Kim, Minseok and Kang, Seungha (2023). Effects of different feeding systems on ruminal fermentation, digestibility, methane emissions, and microbiota of Hanwoo steers. Journal of Animal Science and Technology, 65 (6), 1270-1289. doi: 10.5187/jast.2023.e82
Shah, Ayesha, Kang, Seungha, Fairlie, Thomas, Morrison, Mark and Holtmann, Gerald J. (2023). 1153 VARIATIONS OF THE MUCOSA ASSOCIATED MICROBIOME IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS, ULCERATIVE COLITIS AND ASYMPTOMATIC CONTROLS ALONG THE GASTROINTESTINAL TRACT. Gastroenterology, 164 (6), S-244. doi: 10.1016/s0016-5085(23)01543-3
Organ Transplantation as a Model of Reversible Frailty
(2023–2026) NHMRC IDEAS Grants
(2021–2024) NHMRC IDEAS Grants
Leong, Lex E X, Denman, Stuart E, Kang, Seungha, Mondot, Stanislas, Hugenholtz, Philip and McSweeney, Chris S (2023). - Invited Review - Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota. Animal bioscience, 37 (2), 396-403. doi: 10.5713/ab.23.0351
Lee, Seul, Kim, Jungeun, Baek, Youlchang, Seong, Pilnam, Song, Jaeyong, Kim, Minseok and Kang, Seungha (2023). Effects of different feeding systems on ruminal fermentation, digestibility, methane emissions, and microbiota of Hanwoo steers. Journal of Animal Science and Technology, 65 (6), 1270-1289. doi: 10.5187/jast.2023.e82
Shah, Ayesha, Kang, Seungha, Fairlie, Thomas, Morrison, Mark and Holtmann, Gerald J. (2023). 1153 VARIATIONS OF THE MUCOSA ASSOCIATED MICROBIOME IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS, ULCERATIVE COLITIS AND ASYMPTOMATIC CONTROLS ALONG THE GASTROINTESTINAL TRACT. Gastroenterology, 164 (6), S-244. doi: 10.1016/s0016-5085(23)01543-3
Zhang, Jingwan, SUN, Qianru, Teh, Jing Jie, Kang, Seungha, Hu, Jielun, Lin, Winnie Y., Trakman, Gina L., Sun, Yang, Hamilton, Amy L., Brien, Amy Wilson O’, Ching, Jessica Y., Miao, Yinglei, Sung, Joseph JY, Yu, Jun, Morrison, Mark, Kamm, Michael A. and Ng, Siew C. (2023). 632 IMPACT OF EPIDEMIOLOGIC EVOLUTION, DIET AND EARLY LIFE PROCESSED FOOD INTAKE ON MICROBIOME VARIANCE IN CROHN'S DISEASE. THE INTERNATIONAL ENIGMA STUDY. Gastroenterology, 164 (6), S-125. doi: 10.1016/s0016-5085(23)01261-1
Shanahan, Erin R., Kang, Seungha, Staudacher, Heidi, Shah, Ayesha, Do, Anh, Burns, Grace, Chachay, Veronique S., Koloski, Natasha A., Keely, Simon, Walker, Marjorie M., Talley, Nicholas J., Morrison, Mark and Holtmann, Gerald J. (2023). Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia. Gut, 72 (5) 326158, 929-938. doi: 10.1136/gutjnl-2021-326158
Shah, Ayesha, Sternes, Peter R., Kang, Seungha, Pintos, Camila Ayala, Fairlie, Thomas, Tyson, Gene W., Morrison, Mark and Holtmann, Gerald J. (2023). Mo1798 DENSITY OF THE MUCOSAL BACTERIAL COLONIZATION ALONG THE GASTROINTESTINAL TRACT IN HEALTH AND DISEASE. Gastroenterology, 164 (6), S-915. doi: 10.1016/s0016-5085(23)03108-6
Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). Mo1807 THE SECRETOMES OF COLONIC MUCOSA-ASSOCIATED MICROBIOTA IN CROHN'S DISEASE AND HEALTH IDENTIFY KEY BACTERIA DRIVING PRO- AND ANTI-INFLAMMATORY RESPONSES. THE ENIGMA STUDY. Gastroenterology, 164 (6), S-919. doi: 10.1016/s0016-5085(23)03117-7
Teh, Jing Jie, Kang, Seungha, Leonard, Alarna, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). Mo1811 CHARACTERIZATION OF THE KEY ANTI-INFLAMMATORY BACTERIUM FAECALIBACTERIUM PRAUSNITZII INTERNATIONALLY IN HEALTH AND CROHN'S DISEASE. THE ENIGMA STUDY. Gastroenterology, 164 (6), S-920. doi: 10.1016/s0016-5085(23)03121-9
Kang, Seungha, Teh, Jing Jie, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). Mo1815 CHARACTERIZATION OF THE COLONIC MUCOSA-ASSOCIATED METAGENOME REVEALS NOVEL MICROBES AND GEOGRAPHICALLY DISTINCT COMMUNITIES IN HEALTH AND CROHN'S DISEASE. THE ENIGMA STUDY. Gastroenterology, 164 (6), S-921. doi: 10.1016/s0016-5085(23)03125-6
Loayza, J.J. Jimenez, Kang, S., Schooth, L., Teh, J. J., de Klerk, A., Noon, E. K., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O’Brien, A., Trakman, G. L., Lin, W., Ching, J., Or, L., Sung, J.J.Y., Yu, J., Ng, S.C., Kamm, M.A. and Morrison, M. (2023). Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study. Gut Microbes, 15 (1) 2172670, 1-18. doi: 10.1080/19490976.2023.2172670
Ramos, Sonny C., Kim, Seon Ho, Jeong, Chang Dae, Mamuad, Lovelia L., Son, A-Rang, Kang, Seung Ha, Cho, Yong Il, Kim, Tae Gyu, Lee, Jin Sung, Cho, Kwang Keun, Lee, Sung Sill and Lee, Sang Suk (2022). Increasing buffering capacity enhances rumen fermentation characteristics and alters rumen microbiota composition of high-concentrate fed Hanwoo steers. Scientific Reports, 12 (1) 20739, 20739. doi: 10.1038/s41598-022-24777-3
Shah, Ayesha, Kang, Seungha, Talley, Nicholas J., Do, Anh, Walker, Marjorie M., Shanahan, Erin R., Koloski, Natasha A., Jones, Michael P., Keely, Simon, Morrison, Mark and Holtmann, Gerald J. (2022). The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity. Gut Microbes, 14 (1) 2132078, 1-21. doi: 10.1080/19490976.2022.2132078
Kim, Seon-Ho, Islam, Mahfuzul, Son, A-Rang, Lee, Sung-Sill, Kang, Seung-Ha, Cho, Yong-Il, Park, Kwang-Wook and Lee, Sang-Suk (2021). In vitro assessment of rumen inocula between Jersey and Holstein steers with forage and concentrate substrates. Journal of Agriculture and Life Science, 55 (3), 89-96. doi: 10.14397/jals.2021.55.3.89
Teh, J. J., Berendsen, E. M., Hoedt, E. C., Kang, S., Zhang, J., Zhang, F., Liu, Q., Hamilton, A. L., Wilson-O’Brien, A., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2021). Novel strain-level resolution of Crohn’s disease mucosa-associated microbiota via an ex vivo combination of microbe culture and metagenomic sequencing. The ISME Journal, 15 (11), 3326-3338. doi: 10.1038/s41396-021-00991-1
Islam, Mahfuzul, Kim, Seon-Ho, Son, A-Rang, Ramos, Sonny C., Jeong, Chang-Dae, Yu, Zhongtang, Kang, Seung Ha, Cho, Yong-Il, Lee, Sung-Sill, Cho, Kwang-Keun and Lee, Sang-Suk (2021). Seasonal influence on rumen microbiota, rumen fermentation, and enteric methane emissions of Holstein and Jersey steers under the same total mixed ration. Animals, 11 (4) 1184, 1-22. doi: 10.3390/ani11041184
Ramos, Sonny C., Jeong, Chang Dae, Mamuad, Lovelia L., Kim, Seon Ho, Kang, Seung Ha, Kim, Eun Tae, Cho, Yong Il, Lee, Sung Sill and Lee, Sang Suk (2021). Diet transition from high-forage to high-concentrate alters rumen bacterial community composition, epithelial transcriptomes and ruminal fermentation parameters in dairy cows. Animals, 11 (3) 838, 838-23. doi: 10.3390/ani11030838
Kang, Seungha, Khan, Shahjalal, Webb, Rick, Denman, Stuart and McSweeney, Chris (2020). Characterisation and survey in cattle of a rumen Pyrimadobacter sp. which degrades the plant toxin fluoroacetate. FEMS Microbiology Ecology, 96 (7) fiaa077, 1-11. doi: 10.1093/femsec/fiaa077
Grant, Lucas J., Mikkelsen, Deirdre, Phan, Anh Dao T., Kang, Seungha, Ouwerkerk, Diane, Klieve, Athol V., Gidley, Mike J. and Williams, Barbara (2020). Purified plant cell walls with adsorbed polyphenols alter porcine faecal bacterial communities during in vitro fermentation. Food and Function, 11 (1), 834-845. doi: 10.1039/c9fo02428j
Kang, Seungha, Denman, Stuart, Tahmasbi, Reza and McSweeney, Chris (2019). Draft genome sequence and annotation of sporanaerobacter acetigenes strain F-12, isolated from a cattle rumen. Microbiology Resource Announcements, 8 (30) e00634-19. doi: 10.1128/MRA.00634-19
Draft genome sequence and annotation of Oribacterium sp. strain C9, isolated from a cattle rumen
Kang, Seungha, Denman, Stuart and McSweeney, Chris (2019). Draft genome sequence and annotation of Oribacterium sp. strain C9, isolated from a cattle rumen. Microbiology Resource Announcements, 8 (13) e01562-18. doi: 10.1128/mra.01562-18
Williams, Barbara A., Zhang, Dagong, Lisle, Allan T., Mikkelsen, Deirdre, McSweeney C. S., Kang, Seungha, Bryden, Wayne L. and Gidley, Michael J. (2016). Soluble arabinoxylan enhances large intestinal microbial health biomarkers in pigs fed a red meat-containing diet. Nutrition, 32 (4), 491-497. doi: 10.1016/j.nut.2015.10.008
Gorham, John B., Kang, Seungha, Williams, Barbara A., Grant, Lucas J., McSweeney, Christopher S., Gidley, Michael J. and Mikkelsen, Deirdre (2016). Addition of arabinoxylan and mixed linkage glucans in porcine diets affects the large intestinal bacterial populations. European Journal of Nutrition, 56 (6), 1-14. doi: 10.1007/s00394-016-1263-4
Cloning and characterization of an endoglucanase gene from Actinomyces sp. Korean native goat 40
Kim, Sung Chan, Kang, Seung Ha, Choi, Eun Young, Hong, Yeon Hee, Bok, Jin Duck, Kim, Jae Yeong, Lee, Sang Suk, Choi, Yun Jaie, Choi, In Soon and Cho, Kwang Keun (2016). Cloning and characterization of an endoglucanase gene from Actinomyces sp. Korean native goat 40. Asian-Australasian Journal of Animal Sciences, 29 (1), 126-133. doi: 10.5713/ajas.15.0616
De Cruz, Peter, Kang, Seungha, Wagner, Josef, Buckley, Michael, Sim, Winnie H., Prideaux, Lani, Lockett, Trevor, McSweeney, Chris, Morrison, Mark, Kirkwood, Carl D. and Kamm, Michael A. (2015). Association between specific mucosa-associated microbiota in Crohn's disease at the time of resection and subsequent disease recurrence: a pilot study. Journal of Gastroenterology and Hepatology, 30 (2), 268-278. doi: 10.1111/jgh.12694
Lee, Seung Ho, Cho, Jaiesoon, Bok, Jinduck, Kang, Seungha, Choi, Yunjaie and Lee, Peter C. W. (2014). Characterization, Gene Cloning, and Sequencing of a Fungal Phytase, PhyA, From Penicillium oxalicum PJ3. Preparative Biochemistry and Biotechnology, 45 (4), 336-347. doi: 10.1080/10826068.2014.923446
Prideaux L., Kang S., Wagner J., Buckley M., Mahar J.E., De Cruz P., Wen Z., Chen L., Xia B., Van Langenberg D.R., Lockett T., Ng S.C., Sung J.J.Y., Desmond P., McSweeney C., Morrison M., Kirkwood C.D. and Kamm M.A. (2013). Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease. Inflammatory Bowel Diseases, 19 (13), 2906-2918. doi: 10.1097/01.MIB.0000435759.05577.12
Kang S.H., Evans P., Morrison M. and Mcsweeney C. (2013). Identification of metabolically active proteobacterial and archaeal communities in the rumen by DNA- and RNA-derived 16S rRNA gene. Journal of Applied Microbiology, 115 (3), 644-653. doi: 10.1111/jam.12270
Belobrajdic, Damien P., Bird, Anthony R., Conlon, Michael A., Williams, Barbara A., Kang, Seungha, McSweeney, Christopher S., Zhang, Dagong, Bryden, Wayne L., Gidley, Michael J. and Topping, David L. (2012). An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs. British Journal of Nutrition, 107 (9), 1274-1282. doi: 10.1017/S0007114511004338
Conlon, Michael A., Kerr, Caroline A., McSweeney, Christopher S., Dunne, Robert A., Shaw, Janet M., Kang, Seungha, Bird, Anthony R., Morell, Matthew K., Lockett, Trevor J., Molloy, Peter L., Regina, Ahmed, Toden, Shusuke, Clarke, Julie M. and Topping, David L. (2012). Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet. The Journal of Nutrition, 142 (5), 832-840. doi: 10.3945/jn.111.147660
de Carcer, Daniel Aguirre, Ó Cuív, Páraic, Wang, Tingting, Kang, Seungha, Worthley, Daniel, Whitehall, Vicki, Gordon, Iain, McSweeney, Chris, Leggett, Barbara and Morrison, Mark (2011). Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon. ISME Journal, 5 (5), 801-809. doi: 10.1038/ismej.2010.177
Ó Cuív, Páraic, de Carcer, Daniel Aguirre, Jones, Michelle, Klaassens, Eline S., Worthley, Daniel L., Whitehall, Vicki L. J., Kang, Seungha, McSweeney, Christopher S., Leggett, Barbara A. and Morrison, Mark (2011). The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue. Microbial Ecology, 61 (2), 353-362. doi: 10.1007/s00248-010-9771-x
Highlighting new phylogenetic specificities of Crohn's disease microbiota
Mondot, S., Kang, S., Furet, J.P., Aguirre De Carcer, D., McSweeney, C., Morrison, M., Marteau, P., Dore, J. and Leclerc, M. (2011). Highlighting new phylogenetic specificities of Crohn's disease microbiota. Inflammatory Bowel Diseases, 17 (1), 185-192. doi: 10.1002/ibd.21436
Kang, Seungha, Denman, Stuart E., Morrison, Mark, Yu, Zhongtang, Dore, Joel, Leclerc, Marion and McSweeney, Chris S. (2010). Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray. Inflammatory Bowel Diseases, 16 (12), 2034-2042. doi: 10.1002/ibd.21319
Recent developments in nucleic acid based techniques for use in rumen manipulation
McSweeney, Christopher, Kang, Seungha, Gagen, Emma, Davis, Carl, Morrison, Mark and Denman, Stuart (2009). Recent developments in nucleic acid based techniques for use in rumen manipulation. Revista Brasileira De Zootecnia-Brazilian Journal of Animal Science, 38 (spe), 341-351. doi: 10.1590/S1516-35982009001300034
Kang, Seungha, Denham, Stuart E., Morrison, Mark, Zhongtang, Yu and McSweeney, Chris S. (2009). An efficient RNA extraction method for estimating gut microbial diversity by polymerase chain reaction. Current Microbiology, 58 (5), 464-471. doi: 10.1007/s00284-008-9345-z
Woo, Jung Hee, Lee, Chang Hoon, Cho, Kwang Keun, Kang, Seung Ha, Kang, Sang Kee and Choi, Yun Jaie (2007). Expression and characterization of human growth hormone–Fc fusion proteins for transcytosis induction. Biotechnology and Applied Biochemistry, 46 (4), 211-217. doi: 10.1042/ba20060083
Recombinant production of Penicillium oxalicum PJ3 phytase in Pichia Pastoris
Lee, Jaecheon, Choi, Yunjaie, Lee, Peter-Changwhan, Kang, Seungha, Bok, Jinduck and Cho, Jaiesoon (2006). Recombinant production of Penicillium oxalicum PJ3 phytase in Pichia Pastoris. World Journal of Microbiology and Biotechnology, 23 (3), 443-446. doi: 10.1007/s11274-006-9236-z
Kang, Seungha, Barak, Yoav, Lamed, Raphael, Bayer, Edward A. and Morrison, Mark (2006). The functional repertoire of prokaryote cellulosomes includes the serpin superfamily of serine proteinase inhibitors. Molecular Microbiology, 60 (6), 1344-1354. doi: 10.1111/j.1365-2958.2006.05182.x
Kang, Seung Ha, Cho, Kwang Keun, Bok, Jin Duck, Kim, Sung Chan, Cho, Jaie Soon, Lee, Peter Chang-whan, Kang, Sang Kee, Lee, Hong Gu, Woo, Jung Hee, Lee, Hyun Jeong, Lee, Sang Cheol and Choi, Yun Jaie (2006). Cloning, sequencing and characterization of a novel phosphatase gene, phoI, from soil bacterium Enterobacter sp. 4. Current Microbiology, 52 (4), 243-248. doi: 10.1007/s00284-005-4467-z
Kang, Sang Kee, Cho, Kwang Keun, Ahn, Jong Kun, Kang, Seung Ha, Lee, Seung Ho, Lee, Hong Gu and Choi, Yun Jaie (2005). Cloning, expression, and enzyme characterization of thermostable β-glycosidase from Thermus flavus AT-62. Enzyme and Microbial Technology, 37 (6), 655-662. doi: 10.1016/j.enzmictec.2004.07.026
Chu, Hyuk, Kang, Seungha, Ha, Seckho, Cho, Kwangkeun, Park, Sung-moo, Han, Kyung-ho, Kang, Sang Kee, Lee, HongGu, Han, Seung Hyun, Yun, Cheol H. and Choi, Yunjaie (2005). Lactobacillus acidophilus expressing recombinant K99 adhesive fimbriae has an inhibitory effect on adhesion of enterotoxigenic Escherichia coli. Microbiology and Immunology, 49 (11), 941-948. doi: 10.1111/j.1348-0421.2005.tb03687.x
Molecular cloning of a phytase gene (phy M) from Pseudomonas syringae MOK1
Cho, Jaiesoon, Lee, Changwhan, Kang, Seungha, Lee, Jaecheon, Lee, Honggu, Bok, Jinduck, Woo, Junghee, Moon, Yangsoo and Choi, Yunjaie (2005). Molecular cloning of a phytase gene (phy M) from Pseudomonas syringae MOK1. Current Microbiology, 51 (1), 11-15. doi: 10.1007/s00284-005-4482-0
Kang, Sang Kee, Cho, Kwang Keun, Ahn, Jong Kun, Bok, Jin Duck, Kang, Seung Ha, Woo, Jung Hee, Lee, Hong Gu, You, Seung Kwon and Choi, Yun Jaie (2005). Three forms of thermostable lactose-hydrolase from Thermus sp. IB-21: cloning, expression, and enzyme characterization. Journal of Biotechnology, 116 (4), 337-346. doi: 10.1016/j.jbiotec.2004.07.019
Purification and characterization of a phytase from Pseudomonas syringae MOK1
Cho, Jaie Soon, Lee, Chang Whan, Kang, Seung Ha, Lee, Jae Cheon, Bok, Jin Duck, Moon, Yang Soo, Lee, Hong Gu, Kim, Sung Chan and Choi, Yun Jaie (2003). Purification and characterization of a phytase from Pseudomonas syringae MOK1. Current Microbiology, 47 (4), 290-294. doi: 10.1007/s00284-002-3966-4
Teh, J. J., Kang, S., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Deep functional assessment of the colonic mucosa-associated microbiota in Crohn's disease and health identifies pro- and anti- inflammatory secretomes and associated bacterial consortia. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.1055
Teh, J. J., Kang, S., Leonard, A., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Key anti-inflammatory Faecalibacterium prausnitzii is heterogeneous and diverse in the East and West and in health and Crohn’s disease. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0088
Kang, S., Teh, J. J., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Metagenomic characterisation of the colonic mucosa-associated microbiota reveals novel microbes and communities in health and Crohn’s disease. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0089
Teh, J. J., Kang, S., Zhang, J., Hu, J., Hamilton, A., Wilson-O'Brien, A., Ching, J. Y. L., Lin, W., Trakman, G., Sung, J., Jun, Y., Ng, S., Kamm, M. and Morrison, M. (2022). Deep metagenomic sequencing of the colonic mucosa-associated microbiota shows novel microbes and transnational differences in health and Crohn's disease: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
Schooth, L., Sid-Ahmed, A., Kang, S., Lim, Y., Fairlie, T., Shah, A., Holtmann, G. and Morrison, M. (2022). Diversity of Veillonella in cultures of the duodenal mucosa-associated microbiota suggests species-level differences between people with and without functional gastrointestinal symptoms. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
Elevated artificial sweetener levels are associated with Crohn's disease: The ENIGMA study
Hu, J., Ruan, Y., Lin, W., Trakman, G., Zhang, J., Teh, J. J., Kang, S., Hamilton, A., Wilson-O'Brien, A., Ching, J. Y. L., Sung, J. J. Y., Yu, J., Morrison, M., Kamm, M. A. and Ng, S. C. (2022). Elevated artificial sweetener levels are associated with Crohn's disease: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
Kang, S., Teh, J. J., Schooth, L., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Ching, J. Y. L., Lin, W., Trakman, G. L., Sung, J., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2022). The food additive carrageenan has differential effects on the growth of the mucosa-associated microbiota from Asian and Western people with Crohn's disease and healthy controls: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
Drljaca, Sonja, Vollenbroich, Valeria, Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Lin, Winnie Y., Trakman, Gina L., Sung, Joseph, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2022). Deep characterization of the mucosa-associated microbiota in asian and western populations reveals acidaminococcus occupies a key niche in the nitrogen economy of Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60319-6
Zhang, Jingwan, Sun, Qianru, Teh, Jing Jie, Kang, Seungha, Hu, Jielun, Lin, Winnie Y., Trakman, Gina L., Hamilton, Amy L., Brien, Amy Wilson O’, Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Morrison, Mark, Kamm, Michael A. and Ng, Siew C. (2022). Food additives intake is associated with microbiome dysbiosis and specific pro-inflammatory bacterial changes in Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60218-x
Shah, Ayesha, Sternes, Peter R., Pintos, Camila Ayala, Kang, Seungha, Jones, Michael P., Tyson, Gene, Morrison, Mark and Holtmann, Gerald J. (2022). Influence of proton pump inhibitors on the mucosa associated microbiome in the small intestine and colon. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)62401-6
Schooth, Lauren F., Ahmed, Ahmed Sid, Kang, Seungha, Shah, Ayesha, Fairlie, Thomas, Teh, Jing Jie, Lim, Yenkai, Hoedt, Emily C., Talley, Nicholas J., Keely, Simon, Holtmann, Gerald J. and Morrison, Mark (2022). Strain-level functional and phenotypic resolution of the duodenal mucosa-associated microbiota in functional dyspepsia and healthy control subjects via a novel ex vivo combination of microbe culture and metagenomic sequencing. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)61208-3
Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Lin, Winnie Y., Trakman, Gina L., Sung, Joseph, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2022). Strain-level resolution of the colonic mucosa-associated microbiota reveals novel trans-ethnic differences in health and Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)62327-8
Schooth, L., Kang, S., Lim, Y., Shah, A., Fairlie, T., Jimenez-Loayza, J., Teh, J.-J., Holtmann, G. and Morrison, M. (2021). Differentiation and capture of the human duodenal mucosa-associated microbiota by a novel ex vivo combination of microbe culture and metagenomic sequencing. GESA AGW 2021, Virtual, 4-12 September 2021. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
Kang, Seungha, de Klerk, Ashley, Noon, Ebony, Teh, Jing Jie, Zhang, Jingwan, Zhang, Fen, Liu, Qin, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph J., Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2021). Food additives enhance pro-inflammatory bacterial growth in Crohn's disease mucosa-associated microbiota. The Enigma Study. DDW 2021, Online, 21-23 May 2021. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(21)01036-2
Teh, Jing Jie, Kang, Seungha, Schooth, Lauren F., Loayza, Jeimy Johana Jimenez, Zhang, Jingwan, Zhang, Fen, Liu, Qin, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Sung, Joseph J., Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2021). Sa533 Novel characterization of the secretomes of crohn's disease mucosa-associated microbiota, and their modulation of inflammation through nf-κb signalling. The Enigma Study. DDW 2021, Virtual, 21-23 May 2021. Philadelphia, PA USA: Elsevier. doi: 10.1016/s0016-5085(21)01989-2
Teh, Jing Jie, Kang, Seungha, Murtaza, Nida, Zhang, Jingwan, Zhang, Fen, Liu, Qin, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Sung, Joseph J., Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2020). Microbiota and viruence factors associated with Crohn's Disease recurrence revealed at strain-level resolution by novel combination of microbe culture and metagenomic sequencing (mc-mgs). The Enigma Study. AGA 2020, Online, 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)33265-0
Shah, Ayesha, Talley, Nicholas J., Kang, Seungha, Do, Anh, Walker, Marjorie M., Shanahan, Erin R., Koloski, Natasha A., Jones, Michael P., Keely, Simon, Morrison, Mark and Holtmann, Gerald J. (2020). Self-reported non-celiac wheat sensitivity in patients with chronic unexplained (functional) gastrointestinal symptoms: gut function, immune activation and duodenal mucosa associated microbiome. AGA 2020, Online, 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)31900-4
Shah, Ayesha, Talley, Nicholas, Kang, Seungha, Anh Do,, Walker, Marjorie, Koloski, Natasha, Jones, Michael, Keely, Simon, Morrison, Mark and Holtmann, Gerald (2020). Self-reported non-celiac wheat sensitivity (NCWS) in patients with chronic unexplained (functional) gastrointestinal symptoms. Meeting of the Federation of Neurogastroenterology and Motility, Adelaide, Australia, 25 – 28 March 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Shah, Ayesha, Kang, Seungha, Tyson, Gene, Zaugg, Julian, Hugenholtz, Phil, Morrison, Mark and Holtmann, Gerald J. (2020). Variations of the mucosa associated microbiota along the human gastrointestinal tract in health and inflammatory bowel disease. Crohn's and Colitis Congress, Austin, TX, United States, 23-25 January 2020. Philadelphia, PA, United States: Elsevier . doi: 10.1016/s0016-5085(20)32052-7
Prideaux, L., Kang, S., Wagner, J., Buckley, M., Mahar, J. E., De Cruz, P., Wen, Z., Chen, L., Xia, B., Van Langenberg, D. R., Lockett, T., Ng, S. C., Sung, J. J., Desmond, P., Mcsweeney, C., Morrison, M., Kirkwood, C. D. and Kamm, M. A. (2013). Escalating incidence of IBD in the East and West - Is the microbiota the key? impact of ethnicity, geography, and disease on the microbiota. The ENIGMA study. Australian Gastroenterology Week 2013, Melbourne Australia, 7-9 October 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_2
Iyngkaran, Guru, Kang, Seungha, McSweeney, Chris, Sivanesan, Suresh, Kangaharan, Nadarajah, Morrison, Mark and Macrae, Finlay A. (2013). Tu1693 Indigenous Australians (IA) Have a Distinctive Gut Microbial Profile Compared to Patients With Inflammatory Bowel Disease (IBD) and Non Indigenous Controls. 2013 Digestive Disease Week, Orlando, Florida, 18-21 May 2013. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(13)63057-7
Gut microbiota at the time of Crohn's resection predicts development of disease recurrence
De Cruz, Peter, Kang, Seungha, Sim, Winnie H., Buckley, Michael, Wagner, Josef, Prideaux, Lani, Morrison, Mark, Mcsweeney, Chris, Kirkwood, Carl and Kamm, Michael A. (2012). Gut microbiota at the time of Crohn's resection predicts development of disease recurrence.
Iyngkaran, Guru, Mcsweeney, Chris, Kang, Seungha, Sivanesan, Suresh, Morrison, Mark and Macrae, Finlay (2012). Indigenous Australians (IA) have a distinctive gut microbial profile compared to patient's with inflammatory bowel disease (IBD) and non indigenous controls. Digestive Disease Week, Orlando Fl, May 18-21, 2013. W B SAUNDERS CO-ELSEVIER INC.
De Cruz, Peter P., Kang, Seungha, Prideaux, Lani, McSweeney, Chris, Morrison, Mark and Kamm, Michael A. (2011). Prospective Evaluation of the Mucosa-Associated Microbiota After “Curative” Crohn's Resection Reveals Incomplete Return to “Normal” and Association of Bacteroides With Protection From Disease Recurrence. 2011 Digestive Disease Week , Chicago, Illinois, 7-10 May 2011. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(11)61325-5
Kang, Seungha, Gupta, Arun, Wagner, Josef, Macrae, Finlay A., Morrison, Mark and McSweeney, Chris (2010). T1805 Analysis of the Mucosal Microbiota From Inflammatory Bowel Disease Biopsy Tissues Using a Custom 16s rRNA Based Phylogenetic Microarray. 2010 Digestive Disease Week, New Orleans, Louisiana, 1-5 May 2010. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(10)62683-2
Christophersen, C. T., Kang, S., Mcsweeney, C., Morrison, M., Roberts-Thomson, I. and Conlon, M. A. (2009). The gut microflora of individuals with ulcerative colitis (remission or mild) differs from healthy individuals. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
De Carcer, D. Aguirre, O Cuiv, P., Wang, T., Reverter, T., Worthley, D., Whitehall, V., Klaassens, E. S., Kang, S., Denman, S., Young, G., Legget, B., McSweeney, C. and Morrison, M. (2009). Application of numerical ecology methods to microarray data reveals obscured patterns in the mucosa-associated microbial community of the human colorectum. Australia and New Zealand Medical and Surgical Gastrointestinal Week 2009, Sydney, NSW Australia, 21‐24 October 2009. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
Gidley, M. J., Williams, B. A., Zhang, D., Gunness, P., Mikkelsen, D., Gorham, B., Keates, H., Bryden, W. L., Belobrajdic, D., Conlon, M. A., Kang, S., McSweeney, C., Bird, A. R. and Topping, D. L. (2009). Arabinoxylan improves indices of gut health and reduces DNA damage in pigs consuming a high risk “Western diet”: a pilot study. American Association of Cereal Chemists International 2009 Annual Meeting, Baltimore, MD, United States, 13-16 September 2009.
Organ Transplantation as a Model of Reversible Frailty
(2023–2026) NHMRC IDEAS Grants
(2021–2024) NHMRC IDEAS Grants