Journal Article: Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age
George, J. M., Fiori, S., Fripp, J., Pannek, K., Bursle, J., Moldrich, R. X., Guzzetta, A., Coulthard, A., Ware, R. S., Rose, S. E., Colditz, P. B. and Boyd, R. N. (2017). Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age. American Journal of Neuroradiology, 38 (7), 1435-1442. doi: 10.3174/ajnr.A5191
Journal Article: EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex
Lim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015). EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 (21), 3746-3757. doi: 10.1242/dev.119909
Journal Article: A familial 7q36.3 duplication associated with agenesis of the corpus callosum
Wong, Keith, Moldrich, Randal, Hunter, Matthew, Edwards, Matthew, Finlay, David, O'Donnell, Sheridan, Macdougall, Tom, Bain, Nicole and Kamien, Benjamin (2015). A familial 7q36.3 duplication associated with agenesis of the corpus callosum. American Journal of Medical Genetics, Part A, 167 (9), 2201-2208. doi: 10.1002/ajmg.a.37143
Neurodevelopment of the preterm infant
(2015–2022) NHMRC Project Grant
Mapping cerebral circuits in Down syndrome
(2012–2015) Fondation Jerome Lejeune
The role of epigenetics in epilepsy
(2012) RL Cooper Medical Research Foundation Limited
George, J. M., Fiori, S., Fripp, J., Pannek, K., Bursle, J., Moldrich, R. X., Guzzetta, A., Coulthard, A., Ware, R. S., Rose, S. E., Colditz, P. B. and Boyd, R. N. (2017). Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age. American Journal of Neuroradiology, 38 (7), 1435-1442. doi: 10.3174/ajnr.A5191
EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex
Lim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015). EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 (21), 3746-3757. doi: 10.1242/dev.119909
A familial 7q36.3 duplication associated with agenesis of the corpus callosum
Wong, Keith, Moldrich, Randal, Hunter, Matthew, Edwards, Matthew, Finlay, David, O'Donnell, Sheridan, Macdougall, Tom, Bain, Nicole and Kamien, Benjamin (2015). A familial 7q36.3 duplication associated with agenesis of the corpus callosum. American Journal of Medical Genetics, Part A, 167 (9), 2201-2208. doi: 10.1002/ajmg.a.37143
Fenlon, Laura R., Liu, Sha, Gobius, Ilan, Kurniawan, Nyoman D., Murphy, Skyle, Moldrich, Randal X. and Richards, Linda J. (2015). Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder. Neural Development, 10 (10) 10, 1-14. doi: 10.1186/s13064-015-0033-y
Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model
Guidi, Sandra, Stagni, Fiorenza, Bianchi, Patrizia, Ciani, Elisabetta, Giacomini, Andrea, De Franceschi, Marianna, Moldrich, Randal, Kurniawan, Nyoman, Mardon, Karine, Giuliani, Alessandro, Calzà, Laura and Bartesaghi, Renata (2014). Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model. Brain, 137 (2), 380-401. doi: 10.1093/brain/awt340
Visualization of mouse barrel cortex using ex-vivo track density imaging
Kurniawan, Nyoman D., Richards, Kay L., Yang, Zhengyi, She, David, Ullmann, Jeremy F. P., Moldrich, Randal X., Liu, Sha, Yaksic, Javier Urriola, Leanage, Gayeshika, Kharatishvilia, Irina, Wimmer, Verena, Calamante, Fernando, Galloway, Graham J., Petrou, Steven and Reutens, David C. (2014). Visualization of mouse barrel cortex using ex-vivo track density imaging. NeuroImage, 87, 465-475. doi: 10.1016/j.neuroimage.2013.09.030
X-linked microtubule-associated protein, Mid1, regulates axon development
Lu, Tingjia, Chen, Renchao, Cox, Timothy C., Moldrich, Randal X., Kurniawan, Nyoman, Tan, Guohe, Perry, Jo K., Ashworth, Alan, Bartlett, Perry F., Xu, Li, Zhang, Jing, Lu, Bin, Wu, Mingyue, Shen, Qi, Liu, Yuanyuan, Richards, Linda J. and Xiong, Zhiqi (2013). X-linked microtubule-associated protein, Mid1, regulates axon development. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 19131-19136. doi: 10.1073/pnas.1303687110
Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice
Moldrich, Randal X., Leanage, Gayeshika, She, David, Dolan-Evans, Elliot, Nelson, Michael, Reza, Nargis and Reutens, David C. (2013). Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. Behavioural Brain Research, 257, 253-264. doi: 10.1016/j.bbr.2013.09.049
Multiple Slits regulate the development of midline glial populations and the corpus callosum
Unni, Divya K., Piper, Michael, Moldrich, Randal X., Gobius, Ilan, Liu, Sha, Fothergill, Thomas, Donahoo, Amber-Lee S., Baisden, John M., Cooper, Helen M. and Richards, Linda J. (2012). Multiple Slits regulate the development of midline glial populations and the corpus callosum. Developmental Biology, 365 (1), 36-49. doi: 10.1016/j.ydbio.2012.02.004
Shekarabi, Masoud, Moldrich, Randal X., Rasheed, Sarah, Salin-Cantegrel, Adele, Laganiere, Janet, Rochefort, Daniel, Hince, Pascale, Huot, Karine, Gaudet, Rebecca, Kurniawan, Nyoman, Sotocinal, Susana G., Ritchie, Jennifer, Dion, Patrick A., Mogil, Jeffrey S., Richards, Linda J. and Rouleau, Guy A. (2012). Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. Journal of Neuroscience, 32 (11), 3865-3876. doi: 10.1523/JNEUROSCI.3679-11.2012
Fgfr3 regulates development of the caudal telencephalon
Moldrich, Randal X., Mezzera, Cecilia, Holmes, William M., Goda, Sailaja, Brookfield, Sam J., Rankin, Alastair J., Barr, Emily, Kurniawan, Nyoman, Dewar, Deborah, Richards, Linda J., López-Bendito, Guillermina and Iwata, Tomoko (2011). Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240 (6), 1586-1599. doi: 10.1002/dvdy.22636
Molecular regulation of the developing commissural plate
Moldrich, Randal X., Gobius, Ilan, Pollak, Thomas, Zhang, Jiangyang, Ren, Tianbo, Brown, Lucia, Mori, Susumu, Romero, Camino De Juan, Britanova, Olga, Tarabykin, Victor and Richards, Linda J. (2010). Molecular regulation of the developing commissural plate. Journal of Comparative Neurology, 518 (18), 3645-3661. doi: 10.1002/cne.22445
Cossec, Jack-Christophe, Simon, Anne, Marquer, Catherine, Moldrich, Randal X., Leterrier, Christophe, Rossier, Jean, Duykaerts, Charles, Lenkei, Zsolt and Potier, Marie-Claude (2010). Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol. BBA - Molecular and Cell Biology of Lipids, 1801 (8), 846-852. doi: 10.1016/j.bbalip.2010.05.010
Comparative mouse brain tractography of diffusion magnetic resonance imaging
Moldrich, Randal X., Pannek, Kerstin, Hoch, Renee, Rubenstein, John L., Kurniawan, Nyoman D. and Richards, Linda J. (2010). Comparative mouse brain tractography of diffusion magnetic resonance imaging. NeuroImage, 51 (3), 1027-1036. doi: 10.1016/j.neuroimage.2010.03.035
Piper, Michael, Barry, Guy, Hawkins, John, Mason, Sharon, Lindwall, Charlotta, Little, Erica, Sarkar, Anindita, Smith, Aaron G., Moldrich, Randal X., Boyle, Glen M., Tole, Shubjha, Gronostajski, Richard M., Bailey, Timothy L. and Richards, Linda J. (2010). NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. Journal of Neuroscience, 30 (27), 9127-9139. doi: 10.1523/JNEUROSCI.6167-09.2010
Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
Piper, Michael, Moldrich, Randal, Lindwall, Charlotta, Little, Erica, Barry, Guy, Mason, Sharon, Sunn, Nana, Kurniawan, Nyoman D., Gronostajski, Richard M. and Richards, Linda J. (2009). Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Development, 4 (Article # 43) 43, 1-16. doi: 10.1186/1749-8104-4-43
Moldrich, Randal X., Dauphinot, Luce, Laffaire, Julien, Vitalis, Tania, Herault, Yann, Beart, Philip M., Rossier, Jean, Vivien, Denis, Gehrig, Corinne, Antonarakis, Stylianos E., Lyle, Robert and Potier, Marie-Claude (2009). Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres. Journal of Neuroscience Research, 87 (14), 3143-3152. doi: 10.1002/jnr.22131
Laffaire, Julien, Rivals, Isabelle, Dauphinot, Luce, Pasteau, Fabien, Wehrle, Rosine, Larrat, Benoit, Vitalis, Tania, Moldrich, Randal X., Rossier, Jean, Sinkus, Ralph, Herault, Yann, Dusart, Isabelle and Potier, Marie-Claude (2009). Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. BMC Genomics, 10 (9) 138, 138.1-138.15. doi: 10.1186/1471-2164-10-138
Specific glial populations regulate hippocampal morphogenesis
Barry, Guy, Michael Piper, Lindwall, Charlotta, Moldrich, Randal, Mason, Sharon, Little, Erica, Sarkar, Anindita, Tole, Shubha, Gronostajski, Richard M. and Richards, Linda J. (2008). Specific glial populations regulate hippocampal morphogenesis. The Journal of Neuroscience, 28 (47), 12328-12340. doi: 10.1523/JNEUROSCI.4000-08.2008
Moldrich, R. X., Laine, J., Visel, A., Beart, P. M., Laffaire, J., Rossier, J. and Potier, M. C. (2008). Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain. Neuroscience, 154 (4), 1255-1266. doi: 10.1016/j.neuroscience.2008.01.089
Nuclear Factor I Gene Expression in the Developing Forebrain
Plachez, Celine, Lindwall, Charlotta, Sunn, Nana, Piper, Michael, Moldrich, Randal X., Campbell, Christine E., Osinski, Jason M., Gronostajski, Richard M. and Richards, Linda J. (2008). Nuclear Factor I Gene Expression in the Developing Forebrain. Journal of Comparative Neurology, 508 (3), 385-401. doi: 10.1002/cne.21645
A yeast model of Down syndrome
Moldrich, R. X. (2007). A yeast model of Down syndrome. International journal of developmental neuroscience, 25 (8), 539-543. doi: 10.1016/j.ijdevneu.2007.10.001
Down syndrome gene dosage imbalance on cerebellum development
Moldrich, Randal X., Dauphinot, Luce, Laffaire, Julien, Rossier, Jean and Potier, Marie-Claude (2007). Down syndrome gene dosage imbalance on cerebellum development. Progress in Neurobiology, 82 (2), 87-94. doi: 10.1016/j.pneurobio.2007.02.006
Potier, M.-C., Rivals, I., Mercier, G., Ettwiller, L., Moldrich, R. X., Laffaire, J., Personnaz, L., Rossier, J. and Dauphinot, L. (2006). Transcriptional disruptions in Down syndrome: A case study in the Ts1Cje mouse cerebellum during post-natal development. Journal of Neurochemistry, 97 (s1), 104-109. doi: 10.1111/j.1471-4159.2005.03624.x
Dauphinot, L., Lyle, R., Rivals, I., Dang, M.T., Moldrich, R. X., Golfier, G., Ettwiller, L., Toyama, K., Rossier, J., Personnaz, L., Antonarakis, S. E., Epstein, C. J., Sinet, P. M. and Potier, M. C. (2005). The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome. Human Molecular Genetics, 14 (3), 373-384. doi: 10.1093/hmg/ddi033
Reddrop, C, Moldrich, RX, Beart, PM, Farso, M, Liberatore, GT, Howells, DW, Petersen, KU, Schleuning, WD and Medcalf, RL (2005). Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury. Stroke, 36 (6), 1241-1246. doi: 10.1161/01.STR.0000166050.84056.48
Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors
Moldrich, R. X. and Beart, P. M. (2003). Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors. Current Drug Targets, 2 (2), 109-122. doi: 10.2174/1568007033482922
Glutamate metabotropic receptors as targets for drug therapy in epilepsy
Moldrich, RX, Chapman, AG, De Sarro, G and Meldrumb, BS (2003). Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology, 476 (1-2), 3-16. doi: 10.1016/S0014-2999(03)02149-6
Modulation of intracellular Ca2+ levels by Scorpaenidae venoms
Church, JE, Moldrich, RX, Beart, PM and Hodgson, WC (2003). Modulation of intracellular Ca2+ levels by Scorpaenidae venoms. Toxicon, 41 (6), 679-689. doi: 10.1016/S0041-0101(03)00038-2
Moldrich, RX, Aprico, K, Diwakarla, S, O'Shea, RD and Beart, PM (2002). Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures. Neuropharmacology, 43 (2), 189-203. doi: 10.1016/S0028-3908(02)00111-9
Moldrich, RX, Jeffrey, M, Talebi, A, Beart, PM, Chapman, AG and Meldrum, BS (2001). Anti-epileptic activity of group II metabotropic glutamate receptor agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology, 41 (1), 8-18. doi: 10.1016/S0028-3908(01)00044-2
Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice
Moldrich, RX, Beart, PM, Jane, DE, Chapman, AG and Meldrum, BS (2001). Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology, 40 (5), 732-735. doi: 10.1016/S0028-3908(01)00002-8
Moldrich, RX, Giardina, SF and Beart, PM (2001). Group II mGlu receptor agonists fail to protect against various neurotoxic insults induced in murine cortical, striatal and cerebellar granular pure neuronal cultures. Neuropharmacology, 41 (1), 19-31. doi: 10.1016/S0028-3908(01)00045-4
Moldrich, RX, Talebi, A, Beart, PM, Chapman, AG and Meldrum, BS (2001). The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. Neuroscience Letters, 299 (1-2), 125-129. doi: 10.1016/S0304-3940(00)01732-8
Excitotoxic profile of LY339434, a GluR5 agonist, in cultured murine cortical neurons
Moldrich, Randal X., Cheung, Nam S., Pascoe, Catherine J., Baker, S. Richard, Pedregal, Concepción and Beart, Philip M. (2000). Excitotoxic profile of LY339434, a GluR5 agonist, in cultured murine cortical neurons. Brain Research, 862 (1-2), 270-275. doi: 10.1016/S0006-8993(00)02122-3
Moldrich, Randal X., Beart, Philip M., Pascoe, Catherine J. and Cheung, Nam S. (2000). Low-affinity kainate receptor agonists induce insult-dependent apoptosis and necrosis in cultured murine cortical neurons. Journal of Neuroscience Research, 59 (6), 788-796. doi: 10.1002/(SICI)1097-4547(20000315)59:6<788::AID-JNR11>3.0.CO;2-K
Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures
Moldrich, RX, Cheung, NS, Pascoe, CJ and Beart, PM (1999). Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures. European Journal of Pharmacology, 378 (2), R1-R3. doi: 10.1016/S0014-2999(99)00456-2
Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures
Moldrich, Randal X., Cheung, Nam S., Pascoe, Catherine J. and Beart, Philip M. (1999). Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures. European Journal of Pharmacology, 378 (2), R1-R3. doi: 10.1016/S0014-2999(99)00456-2
How sodium valproate causes language delay and autism - a molecular study
Moldrich, R., Leanage, G. and Reutens, D. (2012). How sodium valproate causes language delay and autism - a molecular study. 10th European Congress on Epileptology, London, United Kingdom, 30 September-4 October 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1528-1167.2012.03677.x
Potier, MC, Dauphinot, L, Dang, MT, Golfier, G, Moldrich, R, Rossier, J, Toyama, K, Sinet, PM, Rivals, I, Personnaz, L, Lyle, R, Antonarakis, S and Epstein, C (2004). Transcriptome modifications in postnatal cerebellum devleopment of Ts1Cje mice, a model for Trisomy 21. 35th Annual Meeting of the Transactions-of-the-American-Society-for-Neurochemistry, New York Ny, Aug 14-18, 2004. OXFORD: BLACKWELL PUBLISHING LTD.
Beart, PM, Aprico, K, O'Shea, RD and Moldrich, RX (2002). Astrocyte mGlu(2/3)-mediated camp potentiation is calcium sensitive: Studies in murine neuronal and astrocyte cultures. 4th International Meeting on Metabotropic Glutamate Receptors, Taorimina Italy, Sep 15-20, 2002. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.
Moldrich, RX, Aprico, K, O'Shea, RD and Beart, PM (2002). The mGlu2/3 agonist 2R,4R-APDC induces adenosine release via phospholipase C and calmodulin kinase in cultured murine astrocytes.. 4th International Meeting on Metabotropic Glutamate Receptors, Taorimina Italy, Sep 15-20, 2002. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.
Moldrich, RX and Beart, PM (2001). The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) and injury in murine pure neuronal cultures. OXFORD: BLACKWELL SCIENCE LTD.
Giardina, SF, Carroll, FY, Moldrich, RX, Finkelstein, DI, Horne, MK, Lawrence, AJ, Cheung, NS and Beart, PM (2001). Kainate receptors, cellular signaling and excitotoxic neuronal death: New pharmacological evidence for the functional involvement of low-affinity and metabotropic kainate receptors. Meeting on Excitatory Amino Acids - 10 Years Later, Manaus Brazil, Nov 18-22, 1998. AMSTERDAM: I O S PRESS.
Agonists for group II mGluRs and neurotoxicity in murine neuronal cultures
Moldrich, RX and Beart, PM (1999). Agonists for group II mGluRs and neurotoxicity in murine neuronal cultures. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.
Beart, PM, Moldrich, RX, Pascoe, CJ and Cheung, NS (1999). Excitotoxicity via low-affinity kainate occurs across an insult-dependent, apoptotic-necrotic continuum. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Neurodevelopment of the preterm infant
(2015–2022) NHMRC Project Grant
Mapping cerebral circuits in Down syndrome
(2012–2015) Fondation Jerome Lejeune
The role of epigenetics in epilepsy
(2012) RL Cooper Medical Research Foundation Limited
The role of the Son gene in the developing brain and Down syndrome
(2009) UQ Early Career Researcher
Down Syndrome candidate gene, Son, in the developing brain
(2008–2009) Fondation Jerome Lejeune
UQ Travel Awards Category 2 - Randal Moldrich
(2008) UQ Travel Grants Scheme
(2007–2009) NHMRC Training (Postdoctoral) Fellowship
Down syndrome gene regulation of the proliferation rate of neural precursor cells
(2007–2008) UQ New Staff Research Start-Up Fund