The University of Queensland

Preclinical optimisation of intrauterine transplantation of fetal mesenchymal stem cells for osteogenesis imperfecta. (2010–2013)

Abstract:

Osteogenesis imperfecta is a genetic disorder causing brittle bones and fractures. Currently there is no good treatment. Transplanting stem cells before birth should allow them to build healthy bones early in life. Despite promising effects in animals, stem cell uptake is too low to prevent all fractures and ameliorate pain & deformity. We are studying how to improve the uptake of stem cells given to the fetus and neonate, in order to develop a treatment suitable for eventual use in humans.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Professor Allison Pettit

  Professor
  

  Mater Research Institute-UQ

  Faculty of Medicine

• 

  Professor Kiarash Khosrotehrani

  St Baker Soyer Chair of Dermatology
  

  Frazer Institute

  Faculty of Medicine

Funded by:

National Health and Medical Research Council