N-glycosylation in health and disease: a key role for Ost3p and Ost6p in regulation of substrate specificity. (2010–2013)
Protein glycosylation is the addition of complex sugar chains to specific proteins. Proteins on the surface of cells are often glycosylated, and this is important for controlling the interactions between cells that occur in development, cancer and infection. Glycosylation can be regulated, and our research will characterize the mechanisms of this regulation. This will help us understand exactly how glycosylation is important in cancer and development.