The University of Queensland

Synthetic lethality screen targeting a defective checkpoint in melanoma (2010–2012)

Abstract:

All cancers have defects in the mechanisms that regulate normal cell growth and division. These defects provide a growth advantage for the cancer, but can also be an Achilles Heel. In this project we will investigate targeting a defective control mechanism we found in a high proportion of melanomas. We will identify genes that when inhibited combine with the defective control to specifically kill tumour cells with this defect. Normal tissue is protected by its intact regulatory mechanism.

Grant type:

Cancer Council Queensland

Researchers:

• 

  Professor Brian Gabrielli

  Honorary Professor
  

  Mater Research Institute-UQ

  Faculty of Medicine

Funded by:

Cancer Council Queensland