Targeting inflammatory epithelial- immune cell networks during viral infection (2024)
- Abstract:
- Influenza A Virus (IAV) is a significant healthcare burden in Australia. Immunopathology, driven by excessive inflammation, underpins severe IAV disease, yet broad-spectrum immunosuppressants do not show clinical benefit. This project will characterise the molecular pathways underpinning an epithelial-immune cell inflammatory network in IAV infection, such that we can selectively inhibit these pathways without compromising anti-viral immune defence. This project will lead to high-impact publications in the innate immunity and virology fields, new models for screening therapeutics and further opportunities for collaboration with key stakeholders, all of which will accelerate my research program.
- Grant type:
- UQ Foundation Research Excellence Awards
- Researchers:
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- Funded by:
- The University of Queensland
