Larisa’s interest in innate immunity started during her honours training with Prof. Matt Sweet at the IMB, looking at how TLR4 signalling is regulated by HDACs. After gaining more experience while working as a research assistant for Prof. Sweet, she moved to Germany to the University of Bonn for her PhD. At the Univeristy of Bonn Larisa investigated the anti-inflammatory effects of High Density Lipoprotein with Prof. Eicke Latz. Larisa then moved to Cambridge, UK as an EMBO postdoctoral fellow to work with Dr. Leo James at the Medical Research Council Laboratory for Molecular Biology. In Dr James' lab Larisa focused on how viruses are sensed by the innate immune system to trigger inflammation. In particular Larisa investigated how antibodies change the way viruses trigger inflammation. While in Cambridge, Larisa was awarded an NHMRC CJ Martin Fellowship to return to Australia. Larisa returned to the IMB in September 2019 to work with Prof. Kate Schroder. Larisa is an IMB Fellow and is continuing to investigate how viruses trigger inflammation.
Larisa's research focuses on understanding how the innate immune system recognizes viruses. This is important so that we can understand the signaling pathways that are involved, and what distinguishes a protective inflammatory response from a dangerous one. Larisa is heavily involved in public outreach and in communicating immunology to the wider public. The importance of this has been particularly clear during the COVID-19 pandemic, when everyone wants to understand why people are getting so sick with COVID-19, how will we know if we are safe from re-infection, and whether vaccines will work.
Journal Article: Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections
Hulme, Katina D., Noye, Ellesandra C., Short, Kirsty R. and Labzin, Larisa I. (2021). Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections. Frontiers in Immunology, 12 770066, 770066. doi: 10.3389/fimmu.2021.770066
Journal Article: Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
Journal Article: Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
Labzin, Larisa I., Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean and James, Leo C. (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, 38 (21) e101365, e101365. doi: 10.15252/embj.2018101365
An active ion transport pathway exploited by coronaviruses
(2022–2024) ARC Discovery Projects
COVID-19-induced vascular complications: mechanisms and potential therapies
(2022–2024) NHMRC IDEAS Grants
Antibodies against Influenza: enhancing macrophage innate immune responses
(2020) UQ Early Career Researcher
Investigating how antibodies against Influenza A Virus modulate macrophage sensing and signalling pathways and outputs.
Doctor Philosophy
Know your enemy: How our innate immune system detects influenza virus infection
Doctor Philosophy
Investigating the vascular dysfunction in COVID-19
Doctor Philosophy
How antibodies modulate sensing of influenza virus
Macrophages, key cells of the innate immune system, recognize Influenza A Virus (IAV) to drive multiple pro-inflammatory responses, including inflammasome-dependent IL-1b release. This inflammatory signalling is protective during initial infection with IAV. However, little is understood of how our innate immune system responds when we are re-infected with IAV.In this project we will uncover how antibodies boost macrophage activation during infection with IAV.
Inflammasomopathies: diseases linked to the NLRP3 inflammasome
De Nardo, Dominic, Vogelhuber, Johanna, Labzin, Larisa, Langhoff, Pia and Latz, Eicke (2012). Inflammasomopathies: diseases linked to the NLRP3 inflammasome. New-opathies: an emerging molecular reclassification of human disease. (pp. 23-65) edited by Errol C. Friedberg, Diego H. Castrillon, Rene L. Galindo and Keith Wharton. Singapore: World Scientific. doi: 10.1142/9789814355698_0002
Hulme, Katina D., Noye, Ellesandra C., Short, Kirsty R. and Labzin, Larisa I. (2021). Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections. Frontiers in Immunology, 12 770066, 770066. doi: 10.3389/fimmu.2021.770066
Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
Labzin, Larisa I., Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean and James, Leo C. (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, 38 (21) e101365, e101365. doi: 10.15252/embj.2018101365
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles and Clatworthy, Menna R. (2019). Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity, 50 (4), 1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006
Innate immunity and neurodegeneration
Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018). Innate immunity and neurodegeneration. Annual Review of Medicine, 69 (1), 437-449. doi: 10.1146/annurev-med-050715-104343
A method for the acute and rapid degradation of endogenous proteins
Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017). A method for the acute and rapid degradation of endogenous proteins. Cell, 171 (7), 1692-1706. doi: 10.1016/j.cell.2017.10.033
Interferons and inflammasomes: cooperation and counterregulation in disease
Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016). Interferons and inflammasomes: cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 (1), 37-46. doi: 10.1016/j.jaci.2016.05.010
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer, Sebastian, Grebe, Alena, Bakke, Siril S., Bode, Niklas, Halvorsen, Bente, Ulas, Thomas, Skjelland, Mona, De Nardo, Dominic, Labzin, Larisa I., Kerksiek, Anja, Hempel, Chris, Heneka, Michael T., Hawxhurst, Victoria, Fitzgerald, Michael L., Trebicka, Jonel, Björkhem, Ingemar, Gustafsson, Jan-Åke, Westerterp, Marit, Tall, Alan R., Wright, Samuel D., Espevik, Terje, Schultze, Joachim L., Nickenig, Georg, Lütjohann, Dieter and Latz, Eicke (2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333) ra50, 333ra50-333ra50. doi: 10.1126/scitranslmed.aad6100
ATF3 is a key regulator of macrophage IFN responses
Labzin, Larisa I., Schmidt, Susanne V., Masters, Seth L., Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L., Latz, Eicke and De Nardo, Dominic (2015). ATF3 is a key regulator of macrophage IFN responses. Journal of Immunology, 195 (9), 4446-4455. doi: 10.4049/jimmunol.1500204
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models
Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc and Schultze, Joachim L. (2014). Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research, 42 (21), 13051-13060. doi: 10.1093/nar/gku1078
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, DeNardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas and Schultze, Joachim L. (2014). Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity, 40 (2), 274-288. doi: 10.1016/j.immuni.2014.01.006
De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan R.G., Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L. and Latz, Eicke (2014). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology, 15 (2), 152-160. doi: 10.1038/ni.2784
Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan and Latz, Eicke (2014). Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. Journal of Immunology, 193 (7), 3257-3261. doi: 10.4049/jimmunol.1301886
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109
Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363
An active ion transport pathway exploited by coronaviruses
(2022–2024) ARC Discovery Projects
COVID-19-induced vascular complications: mechanisms and potential therapies
(2022–2024) NHMRC IDEAS Grants
Antibodies against Influenza: enhancing macrophage innate immune responses
(2020) UQ Early Career Researcher
Innate immune functions of the intracellular antibody receptor TRIM21
(2017–2021) NHMRC Early Career Fellowships
Investigating how antibodies against Influenza A Virus modulate macrophage sensing and signalling pathways and outputs.
Doctor Philosophy — Principal Advisor
Other advisors:
Know your enemy: How our innate immune system detects influenza virus infection
Doctor Philosophy — Principal Advisor
Other advisors:
Investigating the vascular dysfunction in COVID-19
Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
How antibodies modulate sensing of influenza virus
Macrophages, key cells of the innate immune system, recognize Influenza A Virus (IAV) to drive multiple pro-inflammatory responses, including inflammasome-dependent IL-1b release. This inflammatory signalling is protective during initial infection with IAV. However, little is understood of how our innate immune system responds when we are re-infected with IAV.In this project we will uncover how antibodies boost macrophage activation during infection with IAV.