Research Fellow
Affiliate NHMRC Fellow
Overview
Larisa’s interest in innate immunity started during her honours training with Prof. Matt Sweet at the IMB, looking at how TLR4 signalling is regulated by HDACs. After gaining more experience while working as a research assistant for Prof. Sweet, she moved to Germany to the University of Bonn for her PhD. At the Univeristy of Bonn Larisa investigated the anti-inflammatory effects of High Density Lipoprotein with Prof. Eicke Latz. Larisa then moved to Cambridge, UK as an EMBO postdoctoral fellow to work with Dr. Leo James at the Medical Research Council Laboratory for Molecular Biology. In Dr James' lab Larisa focused on how viruses are sensed by the innate immune system to trigger inflammation. In particular Larisa investigated how antibodies change the way viruses trigger inflammation. While in Cambridge, Larisa was awarded an NHMRC CJ Martin Fellowship to return to Australia. Larisa returned to the IMB in September 2019 to work with Prof. Kate Schroder. Larisa is an IMB Fellow and is continuing to investigate how viruses trigger inflammation.
Research Interests
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How antibodies modulate innate immune sensing
Innate sensing of viruses is studied mainly in the context of naive infection. We want to understand how pre-existing immunity, in the form of antibodies, changes the inflammatory response to viruses. -
Human macrophage responses to viruses
Viruses trigger strong inflammatory responses. We are studying the molecular pathways in human macrophages that are triggered during viral infection
Research Impacts
Larisa's research focuses on understanding how the innate immune system recognizes viruses. This is important so that we can understand the signaling pathways that are involved, and what distinguishes a protective inflammatory response from a dangerous one. Larisa is heavily involved in public outreach and in communicating immunology to the wider public. The importance of this has been particularly clear during the COVID-19 pandemic, when everyone wants to understand why people are getting so sick with COVID-19, how will we know if we are safe from re-infection, and whether vaccines will work.
Qualifications
- Doctor of Philosophy, Rheinish-Westphalian Technical University
Publications
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Journal Article: Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
Labzin, Larisa I., Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean and James, Leo C. (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, 38 (21) e101365, e101365. doi: 10.15252/embj.2018101365
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Journal Article: Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles and Clatworthy, Menna R. (2019). Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity, 50 (4), 1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006
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Journal Article: Innate immunity and neurodegeneration
Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018). Innate immunity and neurodegeneration. Annual Review of Medicine, 69, 437-449. doi: 10.1146/annurev-med-050715-104343
Grants
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Antibodies against Influenza: enhancing macrophage innate immune responses
(2020) UQ Early Career Researcher
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Innate immune functions of the intracellular antibody receptor TRIM21
(2017–2021) NHMRC Early Career Fellowships
Available Projects
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How antibodies modulate sensing of influenza virus
Macrophages, key cells of the innate immune system, recognize Influenza A Virus (IAV) to drive multiple pro-inflammatory responses, including inflammasome-dependent IL-1b release. This inflammatory signalling is protective during initial infection with IAV. However, little is understood of how our innate immune system responds when we are re-infected with IAV.In this project we will uncover how antibodies boost macrophage activation during infection with IAV.
Publications
Book Chapter
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Inflammasomopathies: diseases linked to the NLRP3 inflammasome
De Nardo, Dominic, Vogelhuber, Johanna, Labzin, Larisa, Langhoff, Pia and Latz, Eicke (2012). Inflammasomopathies: diseases linked to the NLRP3 inflammasome. New-opathies: an emerging molecular reclassification of human disease. (pp. 23-65) edited by Errol C. Friedberg, Diego H. Castrillon, Rene L. Galindo and Keith Wharton. Singapore: World Scientific. doi: 10.1142/9789814355698_0002
Journal Article
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Labzin, Larisa I., Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean and James, Leo C. (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, 38 (21) e101365, e101365. doi: 10.15252/embj.2018101365
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Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles and Clatworthy, Menna R. (2019). Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity, 50 (4), 1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006
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Innate immunity and neurodegeneration
Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018). Innate immunity and neurodegeneration. Annual Review of Medicine, 69, 437-449. doi: 10.1146/annurev-med-050715-104343
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A method for the acute and rapid degradation of endogenous proteins
Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017). A method for the acute and rapid degradation of endogenous proteins. Cell, 171 (7), 1692-1706. doi: 10.1016/j.cell.2017.10.033
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Interferons and inflammasomes: cooperation and counterregulation in disease
Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016). Interferons and inflammasomes: cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 (1), 37-46. doi: 10.1016/j.jaci.2016.05.010
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Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer, Sebastian, Grebe, Alena, Bakke, Siril S., Bode, Niklas, Halvorsen, Bente, Ulas, Thomas, Skjelland, Mona, De Nardo, Dominic, Labzin, Larisa I., Kerksiek, Anja, Hempel, Chris, Heneka, Michael T., Hawxhurst, Victoria, Fitzgerald, Michael L., Trebicka, Jonel, Björkhem, Ingemar, Gustafsson, Jan-Åke, Westerterp, Marit, Tall, Alan R., Wright, Samuel D., Espevik, Terje, Schultze, Joachim L., Nickenig, Georg, Lütjohann, Dieter and Latz, Eicke (2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333) ra50, 333ra50-333ra50. doi: 10.1126/scitranslmed.aad6100
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ATF3 is a key regulator of macrophage IFN responses
Labzin, Larisa I., Schmidt, Susanne V., Masters, Seth L., Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L., Latz, Eicke and De Nardo, Dominic (2015). ATF3 is a key regulator of macrophage IFN responses. Journal of Immunology, 195 (9), 4446-4455. doi: 10.4049/jimmunol.1500204
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Optimization of transcription factor binding map accuracy utilizing knockout-mouse models
Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc and Schultze, Joachim L. (2014). Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research, 42 (21), 13051-13060. doi: 10.1093/nar/gku1078
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Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, DeNardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas and Schultze, Joachim L. (2014). Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity, 40 (2), 274-288. doi: 10.1016/j.immuni.2014.01.006
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De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan R.G., Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L. and Latz, Eicke (2014). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology, 15 (2), 152-160. doi: 10.1038/ni.2784
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Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan and Latz, Eicke (2014). Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. Journal of Immunology, 193 (7), 3257-3261. doi: 10.4049/jimmunol.1301886
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Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
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Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109
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Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a
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Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363
Grants (Administered at UQ)
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Antibodies against Influenza: enhancing macrophage innate immune responses
(2020) UQ Early Career Researcher
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Innate immune functions of the intracellular antibody receptor TRIM21
(2017–2021) NHMRC Early Career Fellowships
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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How antibodies modulate sensing of influenza virus
Macrophages, key cells of the innate immune system, recognize Influenza A Virus (IAV) to drive multiple pro-inflammatory responses, including inflammasome-dependent IL-1b release. This inflammatory signalling is protective during initial infection with IAV. However, little is understood of how our innate immune system responds when we are re-infected with IAV.In this project we will uncover how antibodies boost macrophage activation during infection with IAV.
